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[PMID]:28742057
[Au] Autor:Gonçalves MLL; Kalil Bussadori S; Dadalti Fragoso Y; da Silva VVB; Melo Deana A; da Mota ACC; Horácio Pinto E; Horliana ACR; Miranda França C
[Ad] Endereço:Postgraduate Program on Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249, Liberdade, ZIP 01504-001, São Paulo, SP, Brazil.
[Ti] Título:Effect of photodynamic therapy in the reduction of halitosis in patients with multiple sclerosis: clinical trial.
[So] Source:J Breath Res;11(4):046006, 2017 Oct 27.
[Is] ISSN:1752-7163
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Smell and odours play a vital role in social interaction. Halitosis is a social problem that affects one third of the population, causing a negative impact on the quality of life. There is little knowledge on the prevalence and management of halitosis in multiple sclerosis (MS) patients. The present study aims to evaluate the presence of halitosis in patients with MS when compared to a control group, and also evaluate treatment of the problem with antimicrobial photodynamic therapy (aPDT). This is a case-control clinical study in which 60 patients were evaluated: 30 MS patients in treatment at the Specialties Clinic School of Medicine, and 30 healthy patients, matched in age and gender for the control group. Data was collected on the duration of the disease as well as the degree of disability and medication use in the MS group. For all patients, halitosis was assessed with Oral Chroma™. Individuals with halitosis underwent treatment with tongue scraping and aPDT. The photosensitizer was methylene blue (0.005%) and a THERAPY XT-EC laser (660 nm, 9 J, 100 mW for 90 s per point, 320 J cm , 3537 mW cm ) was used. Six points 1 cm apart from each other were irradiated in the tongue dorsum. There was a positive correlation between the disability and disease duration. No parameter was correlated with halitosis. Patients with MS have higher levels of SH compounds when compared to the control group (p = 0.003, Mann-Whitney), but after aPDT both groups significantly reduced the levels to under the halitosis threshold. The aPDT scraping treatment was effective in the immediate reduction of halitosis in both groups.
[Mh] Termos MeSH primário: Halitose/complicações
Halitose/tratamento farmacológico
Esclerose Múltipla/complicações
Fotoquimioterapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anti-Infecciosos/uso terapêutico
Testes Respiratórios
Estudos de Casos e Controles
Feminino
Seres Humanos
Masculino
Azul de Metileno/uso terapêutico
Meia-Idade
Fármacos Fotossensibilizantes/uso terapêutico
Qualidade de Vida
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Photosensitizing Agents); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1088/1752-7163/aa8209


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[PMID]:28456679
[Au] Autor:Khaliq NU; Oh KS; Sandra FC; Joo Y; Lee J; Byun Y; Kim IS; Kwon IC; Seo JH; Kim SY; Yuk SH
[Ad] Endereço:College of Pharmacy, Korea University, 2511 Sejongro, Sejong 30019, Republic of Korea.
[Ti] Título:Assembly of polymer micelles through the sol-gel transition for effective cancer therapy.
[So] Source:J Control Release;255:258-269, 2017 Jun 10.
[Is] ISSN:1873-4995
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Photo-induced apoptosis-targeted chemotherapy (PIATC) was designed and characterized to propose a new protocol for improved chemotherapy. Intratumoral injection was selected as the mode of administration of the anticancer drug, doxorubicin (DOX). To extend the retention time of DOX at the tumor parenchyma, in-situ gel formation was induced through the sol-gel transition of the Pluronic NPs containing a prodrug of DOX or a photosensitizer. The prodrug (DEVD-S-DOX) was designed to be inactive with a peptide moiety (Aspartic acid-Glutamic acid-Valine-Aspartic acid: DEVD) linked to DOX and to be cleaved into free DOX by caspase-3 expressed with apoptosis. For reactive oxygen species (ROS)-mediated apoptosis, photo-irradiation with methylene blue (MB, photosensitizer) was utilized. The sol-gel transition of the Pluronic NPs containing reactive species, DEVD-S-DOX or MB, was examined by measuring the cloud point and the gel strength in response to temperature change. ROS-mediated apoptosis was observed by measuring the ROS and membrane integrity with induced apoptosis. The in vivo antitumor efficacy of PIATC was measured with a cardiotoxicity assay in tumor-bearing mice.
[Mh] Termos MeSH primário: Antineoplásicos/administração & dosagem
Doxorrubicina/administração & dosagem
Azul de Metileno/administração & dosagem
Fotoquimioterapia
Fármacos Fotossensibilizantes/administração & dosagem
Poloxâmero/administração & dosagem
Pró-Fármacos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacocinética
Antineoplásicos/uso terapêutico
Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Linhagem Celular Tumoral
Doxorrubicina/farmacocinética
Doxorrubicina/uso terapêutico
Liberação Controlada de Fármacos
Géis
Luz
Masculino
Azul de Metileno/uso terapêutico
Camundongos Endogâmicos C3H
Micelas
Neoplasias/tratamento farmacológico
Neoplasias/metabolismo
Fármacos Fotossensibilizantes/uso terapêutico
Poloxâmero/uso terapêutico
Pró-Fármacos/farmacocinética
Pró-Fármacos/uso terapêutico
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Gels); 0 (Micelles); 0 (Photosensitizing Agents); 0 (Prodrugs); 0 (Reactive Oxygen Species); 106392-12-5 (Poloxamer); 80168379AG (Doxorubicin); EC 3.4.22.- (Caspase 3); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170501
[St] Status:MEDLINE


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[PMID]:29261254
[Au] Autor:Sundararaman B; Muthuramu KL
[Ti] Título:A comparison of mango seed kernel powder, mango leaf powder and Manilkara zapota seed powder for decolorization of methylene blue dye and antimicrobial activity.
[So] Source:J Environ Biol;37(6):1315-21, 2016 11.
[Is] ISSN:0254-8704
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:The waste mango seed generated from mango pulp industry in India is a major problem in handling the waste and hence, conversion of mango seed kernel. Mango seeds were collected and processed for oil extraction. Decolorization of methylene blue was achieved by mango seed kernel powder, mango leaf powder and Manilkara zapota seed powder. Higher efficiency was attained in mango seed kernel powder when compared to mango leaf powder and Manilkara zapota seed powder. A 60 to 95 % of removal efficiency was achieved by varying concentration. Effect of pH, dye concentration, adsorbent dosage and temperature were studied. Mango seed kernel powder is a better option that can be used as an adsorbent for the removal of methylene blue and basic red dye from its aqueous solutions.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Mangifera/química
Manilkara/química
Azul de Metileno/química
Folhas de Planta/química
Sementes/química
[Mh] Termos MeSH secundário: Adsorção
Antibacterianos/química
Antifúngicos/farmacologia
Concentração de Íons de Hidrogênio
Klebsiella pneumoniae/efeitos dos fármacos
Penicillium chrysogenum/efeitos dos fármacos
Temperatura Ambiente
Poluentes Químicos da Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Water Pollutants, Chemical); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE


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[PMID]:29253813
[Au] Autor:de Annunzio SR; de Freitas LM; Blanco AL; da Costa MM; Carmona-Vargas CC; de Oliveira KT; Fontana CR
[Ad] Endereço:Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara. Rodovia Araraquara-Jaú, Km1, Campus Ville, Araraquara, SP, CEP 14800-903, Brazil.
[Ti] Título:Susceptibility of Enterococcus faecalis and Propionibacterium acnes to antimicrobial photodynamic therapy.
[So] Source:J Photochem Photobiol B;178:545-550, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bacterial resistance to available antibiotics nowadays is a global threat leading researchers around the world to study new treatment modalities for infections. Antimicrobial photodynamic therapy (aPDT) has been considered an effective and promising therapeutic alternative in this scenario. Briefly, this therapy is based on the activation of a non-toxic photosensitizing agent, known as photosensitizer (PS), by light at a specific wavelength generating cytotoxic singlet oxygen and free radicals. Virtually all studies related to aPDT involve a huge screening to identify ideal PS concentration and light dose combinations, a laborious and time-consuming process that is hardly disclosed in the literature. Herein, we describe an antimicrobial Photodynamic Therapy (aPDT) study against Enterococcus faecalis and Propionibacterium acnes employing methylene blue, chlorin-e6 or curcumin as PS. Similarities and discrepancies between the two bacterial species were pointed out in an attempt to speed up and facilitate futures studies against those clinical relevant strains. Susceptibility tests were performed by the broth microdilution method. Our results demonstrate that aPDT mediated by the three above-mentioned PS was effective in eliminating both gram-positive bacteria, although P. acnes showed remarkably higher susceptibility to aPDT when compared to E. faecalis. PS uptake assays revealed that P. acnes is 80 times more efficient than E. faecalis in internalizing all three PS molecules. Our results evidence that the cell wall structure is not a limiting feature when predicting bacterial susceptibility to aPDT treatment.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Enterococcus faecalis/efeitos dos fármacos
Fármacos Fotossensibilizantes/farmacologia
Propionibacterium acnes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Curcumina/química
Curcumina/farmacologia
Enterococcus faecalis/efeitos da radiação
Luz
Azul de Metileno/química
Azul de Metileno/farmacologia
Fármacos Fotossensibilizantes/química
Porfirinas/química
Porfirinas/farmacologia
Propionibacterium acnes/efeitos da radiação
Oxigênio Singlete/química
Oxigênio Singlete/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Photosensitizing Agents); 0 (Porphyrins); 17778-80-2 (Singlet Oxygen); 5S2CCF3T1Z (phytochlorin); IT942ZTH98 (Curcumin); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE


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[PMID]:29241121
[Au] Autor:Udayabhanu J; Kannan V; Tiwari M; Natesan G; Giovanni B; Perumal V
[Ad] Endereço:Department of Biotechnology, Periyar University, Periyar Palkalai Nagar, Salem 636 011, Tamil Nadu, India.
[Ti] Título:Nanotitania crystals induced efficient photocatalytic color degradation, antimicrobial and larvicidal activity.
[So] Source:J Photochem Photobiol B;178:496-504, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Textile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause millions of human deaths worldwide. To control mosquitoes a number of synthetic mosquitocidal agents have been employed but all these pesticides pose harmful effects to human health and non-target species and also led to resistance development in treated vectors. Microbial strains are also developing resistance to the available antibiotics, this currently represents a major public health challenge. The current study is focused on the green synthesis of titanium dioxide nanoparticles (TiO NPs) using aqueous leaf extracts of Euphorbia hirta. Results suggested an efficient remedy for the above mentioned problems using TiO NPs against the dye degradation, mosquito larvae and bacterial pathogens. The fabrication of TiO NPs was confirmed by UV-visible spectroscopy, the biomolecules involved in the synthesis process were evidenced by Fourier transform infra-red spectroscopy (FT-IR), the crystalline structure was observed by using X-ray powder diffraction (XRD) analysis. Spherical shaped TiO NPs were recorded using field emission scanning electron microscopy (FESEM). Energy dispersive X-ray spectroscopy (EDX) results showed the elemental composition of TiO NPs. Enhanced rate of photocatalytic dye degradation efficacy was recorded in in methylene blue (95.8%) followed by crystal violet (86.7%). Antibacterial activity assays indicated growth inhibition was highest in Staphylococcus epidermidis and Proteus vulgaris. The LC of TiO NPs and E. hirta extract on Aedes aegypti larvae were 13.2mg/l and 81.2mg/l, while on Culex quinquefasciatus they were 6.89mg/l and 46.1mg/l respectively. Overall, based on the results of the present study, the green engineered nanotitania could be considered as novel and promising photocatalytic, antibacterial, and mosquitocidal agent.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Corantes/química
Nanopartículas Metálicas/química
Titânio/química
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/crescimento & desenvolvimento
Animais
Anti-Infecciosos/farmacologia
Compostos Azo/química
Catálise
Escherichia coli/efeitos dos fármacos
Euphorbia/química
Euphorbia/metabolismo
Química Verde
Larva/efeitos dos fármacos
Luz
Nanopartículas Metálicas/toxicidade
Azul de Metileno/química
Fotólise/efeitos dos fármacos
Fotólise/efeitos da radiação
Extratos Vegetais/química
Folhas de Planta/química
Folhas de Planta/metabolismo
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Azo Compounds); 0 (Coloring Agents); 0 (Plant Extracts); 15FIX9V2JP (titanium dioxide); 6B4TC34456 (methyl orange); D1JT611TNE (Titanium); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28448264
[Au] Autor:Lullove EJ
[Ad] Endereço:West Boca Center for Wound Healing, Boca Raton, FL.
[Ti] Título:Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.
[So] Source:Wounds;29(4):107-114, 2017 04.
[Is] ISSN:1943-2704
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dressings that provide broad spectrum metalloprotease reduction along with inherent aspects of an extracellular matrix may contribute to improved wound healing outcomes and shorter treatment times. OBJECTIVE: The author performed a retrospective case series analysis to determine the clinical outcomes of regular debridement with the use of ovine-based collagen extracellular matrix dressings and gentian violet/methylene blue polyurethane antibacterial foam dressings in treating 53 patients with 53 chronic lower extremity wounds (diabetic foot ulcers [DFUs], venous leg ulcers, and heel pressure ulcers). MATERIALS AND METHODS: Patients were treated twice weekly in an outpatient clinic for the first 4 weeks and weekly thereafter until closure. RESULTS: Average body mass index (BMI) for the study population was 28.3, and the average patient age was 75.9 years. Mean percent wound surface area reduction at 4, 8, and 12 weeks was 38.5%, 73.3%, and 91.3%, respectively. Average time to closure for all wounds was 10.6 weeks (range, 5-24 weeks). All wounds were 100% reepithelialized by week 20 except 1 DFU that reepithelialized at week 24. The average cost of care for a single wound episode (from presentation to closure) was $2749.49. CONCLUSION: Results of this analysis showed that the healing of chronic wounds in this series could be achieved at a reasonable cost with regular debridement and a collagen matrix dressing regimen, even in patients of advanced age and above average BMI as well as in wounds that did not achieve > 40% wound surface area reduction at 4 weeks.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Pé Diabético/terapia
Violeta de Genciana/uso terapêutico
Úlcera da Perna/terapia
Azul de Metileno/uso terapêutico
Lesão por Pressão/terapia
Úlcera Varicosa/terapia
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Idoso
Assistência Ambulatorial/métodos
Colágeno Tipo IV/farmacologia
Colágeno Tipo IV/uso terapêutico
Desbridamento/métodos
Pé Diabético/patologia
Matriz Extracelular/patologia
Feminino
Violeta de Genciana/farmacologia
Seres Humanos
Úlcera da Perna/patologia
Masculino
Azul de Metileno/farmacologia
Curativos Oclusivos
Lesão por Pressão/patologia
Estudos Retrospectivos
Resultado do Tratamento
Úlcera Varicosa/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Collagen Type IV); J4Z741D6O5 (Gentian Violet); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180103
[Lr] Data última revisão:
180103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE


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[PMID]:29185900
[Au] Autor:Shahabadi N; Asadian AA; Mahdavi M
[Ad] Endereço:a Inorganic Chemistry Department, Faculty of Chemistry , Razi University , Kermanshah , Iran.
[Ti] Título:Intercalation of a Zn(II) complex containing ciprofloxacin drug between DNA base pairs.
[So] Source:Nucleosides Nucleotides Nucleic Acids;36(11):676-689, 2017 Nov 02.
[Is] ISSN:1532-2335
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, an attempt has been made to study the interaction of a Zn(II) complex containing an antibiotic drug, ciprofloxacin, with calf thymus DNA using spectroscopic methods. It was found that Zn(II) complex could bind with DNA via intercalation mode as evidenced by: hyperchromism in UV-Vis spectrum; these spectral characteristics suggest that the Zn(II) complex interacts with DNA most likely through a mode that involves a stacking interaction between the aromatic chromophore and the base pairs of DNA. DNA binding constant (K = 1.4 × 10 M ) from spectrophotometric studies of the interaction of Zn(II) complex with DNA is comparable to those of some DNA intercalative polypyridyl Ru(II) complexes 1.0 -4.8 × 10 M . CD study showed stabilization of the right-handed B form of DNA in the presence of Zn(II) complex as observed for the classical intercalator methylene blue. Thermodynamic parameters (ΔH < 0 and ΔS < 0) indicated that hydrogen bond and Van der Waals play main roles in this binding prose. Competitive fluorimetric studies with methylene blue (MB) dye have shown that Zn(II) complex exhibits the ability of this complex to displace with DNA-MB, indicating that it binds to DNA in strong competition with MB for the intercalation.
[Mh] Termos MeSH primário: Pareamento de Bases
Ciprofloxacino/química
Complexos de Coordenação/química
Complexos de Coordenação/farmacologia
DNA/química
Zinco/química
[Mh] Termos MeSH secundário: Animais
Ligação Competitiva
Bovinos
Complexos de Coordenação/metabolismo
DNA/metabolismo
Substâncias Intercalantes/química
Substâncias Intercalantes/metabolismo
Substâncias Intercalantes/farmacologia
Azul de Metileno/metabolismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coordination Complexes); 0 (Intercalating Agents); 5E8K9I0O4U (Ciprofloxacin); 9007-49-2 (DNA); 91080-16-9 (calf thymus DNA); J41CSQ7QDS (Zinc); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1080/15257770.2017.1388394


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[PMID]:27777201
[Au] Autor:Cui JZ; Zhang JW; Zhang Y; Ma ZL
[Ad] Endereço:Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China. E-mail: cuijizheng@126.com.
[Ti] Título:[Efficacy of intracutaneous methylene blue injection for moderate to severe acute thoracic herpes zoster pain and prevention of postherpetic neuralgia in elderly patients].
[So] Source:Nan Fang Yi Ke Da Xue Xue Bao;36(10):1377-1381, 2016 Oct 20.
[Is] ISSN:1673-4254
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To evaluate the clinical efficacy of intradermal injection of methylene blue for treatment of moderate to severe acute thoracic herpes zoster and prevention of postherpetica neuralgia in elderly patients. METHODS: Sixty-four elderly patients with herpes zoster were randomized to receive a 10-day course of intradermal injection of methylene blue and lidocaine plus oral valaciclovir (group A, 32 cases) and intradermal injection of lidocaine plus oral valaciclovir (group B).Herpes evaluation index, pain rating index, incidence of postherpetic neuralgia, and comprehensive therapeutic effect were compared between the two groups at 11, 30 and 60 days after the treatment. RESULTS: The baseline characteristics were comparable between the two groups (all P>0.05). Compared with that in group B, the time for no new blister formation, blister incrustation and decrustation, and pain relief was significantly shortened in group A (P<0.05) with also obviously lower pain intensity after the treatment. The incidence of postherpetic neuralgia was significantly lower in group A than in group B at 30 days (P<0.05), but not at 60 and 90 days after the treatment. The total clinical response rate was 93.8% in group A, much higher than that in group B (62.5%, P<0.05). CONCLUSION: Intradermal injection of methylene blue can effectively shorten the disease course, reduce the pain intensity and prevent the development of postherpetic neuralgia in elderly patients with herpes zoster.
[Mh] Termos MeSH primário: Herpes Zoster/complicações
Azul de Metileno/administração & dosagem
Neuralgia Pós-Herpética/terapia
[Mh] Termos MeSH secundário: Aciclovir/administração & dosagem
Aciclovir/análogos & derivados
Aciclovir/uso terapêutico
Idoso
Seres Humanos
Incidência
Injeções Intradérmicas
Lidocaína/administração & dosagem
Lidocaína/uso terapêutico
Azul de Metileno/uso terapêutico
Medição da Dor
Valina/administração & dosagem
Valina/análogos & derivados
Valina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
98PI200987 (Lidocaine); HG18B9YRS7 (Valine); MZ1IW7Q79D (valacyclovir); T42P99266K (Methylene Blue); X4HES1O11F (Acyclovir)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28855017
[Au] Autor:Gülen J; Zorbay F
[Ti] Título:Methylene Blue Adsorption on a Low Cost Adsorbent-Carbonized Peanut Shell.
[So] Source:Water Environ Res;89(9):805-816, 2017 Sep 01.
[Is] ISSN:1061-4303
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carbonized peanut shell (CPS), a low cost adsorbent was investigated for adsorption of methylene blue from its aqueous solution. Some experimental parameters like the effect of initial dye concentration, initial solution pH, phases contact time and temperature were investigated. Langmuir, Freundlich and Harkins-Jura isotherm models were applied to the experimental data and Langmuir model fitted best. Monolayer adsorption capacity was 5.34 mg/g according to the Langmuir model. Adsorption capacity/uptake of CPS was found comparable to the some other adsorbent materials. The kinetic and intra particle diffusion models were applied to the experimental data. The experimental reaction was progressed via pseudo second order kinetic model. The thermodynamic parameters were also evaluated.
[Mh] Termos MeSH primário: Arachis/química
Carbono/química
Inibidores Enzimáticos/química
Azul de Metileno/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Adsorção
Microscopia Eletrônica de Varredura
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Water Pollutants, Chemical); 7440-44-0 (Carbon); T42P99266K (Methylene Blue)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.2175/106143017X14902968254836


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[PMID]:28854795
[Au] Autor:Michútová M; Mrázová V; Kúdelová M; Smolinská M; Supoliková M; Vrbová M; Golais F
[Ti] Título:Herpes simplex viruses type 1 and 2 photoinactivated in the presence of methylene blue transform human and mouse cells in vitro.
[So] Source:Acta Virol;61(3):308-315, 2017.
[Is] ISSN:0001-723X
[Cp] País de publicação:Slovakia
[La] Idioma:eng
[Ab] Resumo:Three strains of herpes simplex virus, K17syn- and HSZPsyn+ of type 1 (HSV-1) and USsyn- of type 2 (HSV-2), were photoinactivated in the presence of methylene blue and used to infect 3 cell lines, normal human lung tissue cells (MRC-5), mouse epithelial cells (NIH3T3), and human lung carcinoma cells (A549). The virus titer and phenotype of cells were evaluated to compare the characteristics of normal and carcinoma cells infected with non-syncytial (non-syn) and syncytial (syn) strains of herpes simplex viruses. We found that the cells of both normal cell lines infected with photoinactivated K17syn- and USsyn- but not HSZPsyn+ acquired transformed phenotype accompanied by the presence of virus. Surprisingly, the infection with photoinactivated viruses K17syn- and USsyn- but not HSZPsyn+ resulted in the suppression of the transformed phenotype of A549 cells. Using nested PCR, herpesviral DNA was identified in newly transformed cells and cells that lost the transformed phenotype. The effect of putative herpesvirus-related growth factors (HRGF) produced by cells infected with photoinactivated viruses was quantified and compared. Since methylene blue is currently used in phototherapy of herpetic lesions, these results raise the question of whether such therapy is risky to human health.
[Mh] Termos MeSH primário: Herpes Simples/virologia
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 1/metabolismo
Herpesvirus Humano 2/efeitos dos fármacos
Herpesvirus Humano 2/metabolismo
Azul de Metileno/administração & dosagem
[Mh] Termos MeSH secundário: Células A549
Animais
Linhagem Celular
Linhagem Celular Tumoral
Seres Humanos
Masculino
Camundongos
Meia-Idade
Células NIH 3T3
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
T42P99266K (Methylene Blue)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.4149/av_2017_309



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