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[PMID]:28301040
[Au] Autor:Tian R; Shi R
[Ad] Endereço:Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, USA.
[Ti] Título:Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury.
[So] Source:J Neurochem;141(5):708-720, 2017 Jun.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acrolein is one of the most toxic byproducts of lipid peroxidation, and it has been shown to be associated with multiple pathological processes in trauma and diseases, including spinal cord injury, multiple sclerosis, and Alzheimer's disease. Therefore, suppressing acrolein using acrolein scavengers has been suggested as a novel strategy of neuroprotection. In an effort to identify effective acrolein scavengers, we have confirmed that dimercaprol, which possesses thiol functional groups, could bind and trap acrolein. We demonstrated the reaction between acrolein and dimercaprol in an abiotic condition by nuclear magnetic resonance spectroscopy. Specifically, dimercaprol is able to bind to both the carbon double bond and aldehyde group of acrolein. Its acrolein scavenging capability was further demonstrated by in vitro results that showed that dimercaprol could significantly protect PC-12 cells from acrolein-mediated cell death in a dose-dependent manner. Furthermore, dimercaprol, when applied systemically through intraperitoneal injection, could significantly reduce acrolein contents in spinal cord tissue following a spinal cord contusion injury in rats, a condition known to have elevated acrolein concentration. Taken together, dimercaprol may be an effective acrolein scavenger and a viable candidate for acrolein detoxification.
[Mh] Termos MeSH primário: Acroleína/toxicidade
Dimercaprol/uso terapêutico
Depuradores de Radicais Livres/uso terapêutico
Traumatismos da Medula Espinal/induzido quimicamente
Traumatismos da Medula Espinal/tratamento farmacológico
[Mh] Termos MeSH secundário: Acroleína/química
Acroleína/metabolismo
Animais
Peso Corporal/efeitos dos fármacos
Morte Celular/efeitos dos fármacos
Dimercaprol/química
Dimercaprol/farmacologia
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Interações Medicamentosas
Depuradores de Radicais Livres/farmacologia
L-Lactato Desidrogenase/metabolismo
Espectroscopia de Ressonância Magnética
Masculino
Células PC12/efeitos dos fármacos
Ratos
Medula Espinal/efeitos dos fármacos
Medula Espinal/metabolismo
Traumatismos da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radical Scavengers); 0CPP32S55X (Dimercaprol); 7864XYD3JJ (Acrolein); EC 1.1.1.27 (L-Lactate Dehydrogenase)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1111/jnc.14025


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[PMID]:28202547
[Au] Autor:McElroy PB; Sri Hari A; Day BJ; Patel M
[Ad] Endereço:From the Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045 and.
[Ti] Título:Post-translational Activation of Glutamate Cysteine Ligase with Dimercaprol: A NOVEL MECHANISM OF INHIBITING NEUROINFLAMMATION .
[So] Source:J Biol Chem;292(13):5532-5545, 2017 Mar 31.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuroinflammation and oxidative stress are hallmarks of various neurological diseases. However, whether and how the redox processes control neuroinflammation is incompletely understood. We hypothesized that increasing cellular glutathione (GSH) levels would inhibit neuroinflammation. A series of thiol compounds were identified to elevate cellular GSH levels by a novel approach ( post-translational activation of glutamate cysteine ligase (GCL), the rate-limiting enzyme in GSH biosynthesis). These small thiol-containing compounds were examined for their ability to increase intracellular GSH levels in a murine microglial cell line (BV2), of which dimercaprol (2,3-dimercapto-1-propanol (DMP)) was found to be the most effective compound. DMP increased GCL activity and decreased LPS-induced production of pro-inflammatory cytokines and inducible nitric-oxide synthase induction in BV2 cells in a concentration-dependent manner. The ability of DMP to elevate GSH levels and attenuate LPS-induced pro-inflammatory cytokine production was inhibited by buthionine sulfoximine, an inhibitor of GCL. DMP increased the expression of GCL holoenzyme without altering the expression of its subunits or Nrf2 target proteins (NQO1 and HO-1), suggesting a post-translational mechanism. DMP attenuated LPS-induced MAPK activation in BV2 cells, suggesting the MAPK pathway as the signaling mechanism underlying the effect of DMP. Finally, the ability of DMP to increase GSH via GCL activation was observed in mixed cerebrocortical cultures and N27 dopaminergic cells. Together, the data demonstrate a novel mechanism of GSH elevation by post-translational activation of GCL. Post-translational activation of GCL offers a novel targeted approach to control inflammation in chronic neuronal disorders associated with impaired adaptive responses.
[Mh] Termos MeSH primário: Dimercaprol/farmacologia
Glutamato-Cisteína Ligase/metabolismo
Inflamação/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Citocinas/antagonistas & inibidores
Ativação Enzimática/efeitos dos fármacos
Glutamato-Cisteína Ligase/efeitos dos fármacos
Glutationa/metabolismo
Sistema de Sinalização das MAP Quinases
Camundongos
Sistema Nervoso/patologia
Oxirredução
Ratos
Compostos de Sulfidrila/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Sulfhydryl Compounds); 0CPP32S55X (Dimercaprol); EC 6.3.2.2 (Glutamate-Cysteine Ligase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170612
[Lr] Data última revisão:
170612
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.723700


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[PMID]:27636894
[Au] Autor:Li C; Srivastava RK; Athar M
[Ad] Endereço:Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, Alabama.
[Ti] Título:Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals.
[So] Source:Ann N Y Acad Sci;1378(1):143-157, 2016 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Arsenicals are highly reactive inorganic and organic derivatives of arsenic. These chemicals are very toxic and produce both acute and chronic tissue damage. On the basis of these observations, and considering the low cost and simple methods of their bulk syntheses, these agents were thought to be appropriate for chemical warfare. Among these, the best-known agent that was synthesized and weaponized during World War I (WWI) is Lewisite. Exposure to Lewisite causes painful inflammatory and blistering responses in the skin, lung, and eye. These chemicals also manifest systemic tissue injury following their cutaneous exposure. Although largely discontinued after WWI, stockpiles are still known to exist in the former Soviet Union, Germany, Italy, the United States, and Asia. Thus, access by terrorists or accidental exposure could be highly dangerous for humans and the environment. This review summarizes studies that describe the biological, pathophysiological, toxicological, and environmental effects of exposure to arsenicals, with a major focus on cutaneous injury. Studies related to the development of novel molecular pathobiology-based antidotes against these agents are also described.
[Mh] Termos MeSH primário: Intoxicação por Arsênico/metabolismo
Arsenicais/administração & dosagem
Substâncias para a Guerra Química/envenenamento
Exposição Ambiental/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Intoxicação por Arsênico/tratamento farmacológico
Intoxicação por Arsênico/epidemiologia
Guerra Química/tendências
Dimercaprol/uso terapêutico
Seres Humanos
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Arsenicals); 0 (Chemical Warfare Agents); 0 (Reactive Oxygen Species); 0CPP32S55X (Dimercaprol); 0N54LGU5WS (lewisite)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160917
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13214


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[PMID]:27398446
[Au] Autor:Rene HD; Badireddy AR; José MS; Francisco CC; Israel MG; Isela SN; Chellam S; Claudio CR
[Ti] Título:Cytotoxic Effect of Lipophilic Bismuth Dimercaptopropanol Nanoparticles on Epithelial Cells.
[So] Source:J Nanosci Nanotechnol;16(1):203-9, 2016 Jan.
[Is] ISSN:1533-4880
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Bismuth nanoparticles have many interesting properties to be applied in biomedical and medicinal sectors, however their safety in humans have not been comprehensively investigated. The objective of this research was to determine the cytotoxic effect of bismuth dimercaptopropanol nanoparticles (BisBAL NPs) on epithelial cells. The nanoparticles are composed of 18.7 nm crystallites on average and have a rhombohedral structure, agglomerating into chains-like or clusters of small nanoparticles. Based on MTT viability assay and fluorescence microscopy, cytotoxicity was not observed on monkey kidney cells after growing with 5 µM of BisBAL NPs for 24 h. Employing same techniques, identical results were obtained with human epithelial cells (HeLa), showing a not strain-dependent phenomenon. The absence of toxic effects on epithelial cells growing with BisBAL NPs was corroborated with long-time experiments (24-72 hrs.), showing no difference in comparison with growing control (cells without nanoparticles). Further, genotoxicity assays, comet assay and fluorescent microscopy and electrophoresis in bromide-stained agarose gel revealed no damage to genomic DNA of MA104 cells after 24 h. of exposition to BisBAL NPs. Finally, the effect of bismuth nanoparticles on protein synthesis was studied in cells growing with BisBAL NPs for 24 h. SDS-PAGE assays showed no difference between treated and untreated cells, suggesting that BisBAL NPs did not interfere with protein synthesis. Hence BisBAL NPs do not appear to exert cytotoxic effects suggesting their biological compatibility with epithelial cells.
[Mh] Termos MeSH primário: Bismuto
Citotoxinas
Dimercaprol/análogos & derivados
Células Epiteliais/metabolismo
Nanopartículas/química
Compostos Organometálicos
[Mh] Termos MeSH secundário: Animais
Bismuto/química
Bismuto/farmacologia
Cercopithecus aethiops
Citotoxinas/química
Citotoxinas/farmacologia
Dimercaprol/química
Dimercaprol/farmacologia
Células Epiteliais/citologia
Seres Humanos
Compostos Organometálicos/química
Compostos Organometálicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Organometallic Compounds); 0 (bismuth dimercaptopropanol); 0CPP32S55X (Dimercaprol); U015TT5I8H (Bismuth)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160711
[Lr] Data última revisão:
160711
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


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[PMID]:26508422
[Au] Autor:Shumy F; Anam AM; Kamruzzaman AK; Amin MR; Chowdhury MA
[Ad] Endereço:Medical Officer, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh farzanashumy@hotmail.com.
[Ti] Título:Acute arsenic poisoning diagnosed late.
[So] Source:Trop Doct;46(2):93-6, 2016 Apr.
[Is] ISSN:1758-1133
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Acute arsenicosis, although having a 'historical' background, is not common in our times. This report describes a case of acute arsenic poisoning, missed initially due to its gastroenteritis-like presentation, but suspected and confirmed much later, when the patient sought medical help for delayed complications after about 2 months.
[Mh] Termos MeSH primário: Intoxicação por Arsênico/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Intoxicação por Arsênico/sangue
Intoxicação por Arsênico/tratamento farmacológico
Quelantes/administração & dosagem
Quelantes/uso terapêutico
Diagnóstico Diferencial
Dimercaprol/administração & dosagem
Dimercaprol/uso terapêutico
Seres Humanos
Injeções Intramusculares
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0CPP32S55X (Dimercaprol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1177/0049475515610940


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[PMID]:26479948
[Au] Autor:Harper LK; Bayse CA
[Ad] Endereço:Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, United States.
[Ti] Título:Modeling the chelation of As(III) in lewisite by dithiols using density functional theory and solvent-assisted proton exchange.
[So] Source:J Inorg Biochem;153:60-7, 2015 Dec.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dithiols such as British anti-lewisite (BAL, rac-2,3-dimercaptopropanol) are an important class of antidotes for the blister agent lewisite (trans-2-chlorovinyldichloroarsine) and, more generally, are chelating agents for arsenic and other toxic metals. The reaction of the vicinal thiols of BAL with lewisite through the chelation of the As(III) center has been modeled using density functional theory (DFT) and solvent-assisted proton exchange (SAPE), a microsolvation method that uses a network of water molecules to mimic the role of bulk solvent in models of aqueous phase chemical reactions. The small activation barriers for the stepwise SN2-type nucleophilic attack of BAL on lewisite (0.7-4.9kcal/mol) are consistent with the favorable leaving group properties of the chloride and the affinity of As(III) for soft sulfur nucleophiles. Small, but insignificant, differences in activation barriers were found for the initial attack of the primary versus secondary thiol of BAL and the R vs S enantiomer. An examination of the relative stability of various dithiol-lewisite complexes shows that ethanedithiols like BAL form the most favorable chelation complexes because the angles formed in five-membered ring are most consistent with the hybridization of As(III). More obtuse S-As-S angles are required for larger chelate rings, but internal As⋯N or As⋯O interactions can enhance the stability of moderate-sized rings. The low barriers for lewisite detoxification by BAL and the greater stability of the chelation complexes of small dithiols are consistent with the rapid reversal of toxicity demonstrated in previously reported animal models.
[Mh] Termos MeSH primário: Arsênico/química
Arsenicais/química
Quelantes/química
Dimercaprol/química
[Mh] Termos MeSH secundário: Substâncias para a Guerra Química/química
Modelos Químicos
Prótons
Teoria Quântica
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenicals); 0 (Chelating Agents); 0 (Chemical Warfare Agents); 0 (Protons); 059QF0KO0R (Water); 0CPP32S55X (Dimercaprol); 0N54LGU5WS (lewisite); N712M78A8G (Arsenic)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151020
[St] Status:MEDLINE


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[PMID]:25015930
[Au] Autor:Permar S; Gorman K; Lercher D; Bradford KK
[Ad] Endereço:University of North Carolina School of Medicine, Chapel Hill, NC, USA stephanie.permar@unchealth.unc.edu.
[Ti] Título:Rare etiology of abdominal pain in an adolescent female.
[So] Source:Clin Pediatr (Phila);54(1):94-7, 2015 Jan.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Intoxicação por Chumbo/complicações
Intoxicação por Chumbo/diagnóstico
[Mh] Termos MeSH secundário: Adolescente
Quelantes/uso terapêutico
Diagnóstico Diferencial
Dimercaprol/uso terapêutico
Ácido Edético/uso terapêutico
Feminino
Hematemese/etiologia
Seres Humanos
Intoxicação por Chumbo/tratamento farmacológico
Succímero/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0CPP32S55X (Dimercaprol); 9G34HU7RV0 (Edetic Acid); DX1U2629QE (Succimer)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:141204
[Lr] Data última revisão:
141204
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:140713
[St] Status:MEDLINE
[do] DOI:10.1177/0009922814542609


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[PMID]:24352565
[Au] Autor:Kuo CY; Wang HC; Kung PH; Lu CY; Liao CY; Wu MT; Wu CC
[Ti] Título:Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets.
[So] Source:Thromb Haemost;111(5):892-901, 2014 May 05.
[Is] ISSN:0340-6245
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:CalDAG-GEFI, a guanine nucleotide exchange factor activating Rap1, is known to play a key role in Ca2+-dependent glycoprotein (GP)IIb/IIIa activation and platelet aggregation. Although inhibition of CalDAG-GEFI could be a potential strategy for antiplatelet therapy, no inhibitor of this protein has been identified. In the present study, phenylarsine oxide (PAO), a vicinal dithiol blocker, potently prevented Rap1 activation in thrombin-stimulated human platelets without significantly inhibiting intracellular Ca2+ mobilisation and protein kinase C activation. PAO also prevented the Ca2+ ionophore-induced Rap1 activation and platelet aggregation, which are dependent on CalDAG-GEFI. In the biotin-streptavidin pull-down assay, CalDAG-GEFI was efficiently pull-downed by streptavidin beads from the lysates of biotin-conjugated PAO-treated platelets, suggesting that PAO binds to intracellular CalDAG-GEFI with high affinity. The above effects of PAO were reversed by a vicinal dithiol compound 2,3-dimercaptopropanol. In addition, CalDAG-GEFI formed disulfide-linked oligomers in platelets treated with the thiol-oxidant diamide, indicating that CalDAG-GEFI contains redox-sensitive thiols. In a purified recombinant protein system, PAO directly inhibited CalDAG-GEFI-stimulated GTP binding to Rap1. Using CalDAG-GEFI and Rap1-overexpressed human embryonic kidney 293T cells, we further confirmed that PAO abolished Ca2+-mediated Rap1 activation. Taken together, these results have demonstrated that CalDAG-GEFI is one of the targets of action of PAO, and propose an important role of vicinal cysteines for the functions of CalDAG-GEFI.
[Mh] Termos MeSH primário: Arsenicais/farmacologia
Plaquetas/efeitos dos fármacos
Fatores de Troca do Nucleotídeo Guanina/metabolismo
Trombose/tratamento farmacológico
Proteínas rap1 de Ligação ao GTP/metabolismo
[Mh] Termos MeSH secundário: Plaquetas/fisiologia
Diamida/farmacologia
Dimercaprol/farmacologia
Fatores de Troca do Nucleotídeo Guanina/isolamento & purificação
Células HEK293
Seres Humanos
Terapia de Alvo Molecular
Oxirredução/efeitos dos fármacos
Agregação Plaquetária/efeitos dos fármacos
Ligação Proteica/efeitos dos fármacos
Trombina/metabolismo
Tolueno/análogos & derivados
Tolueno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arsenicals); 0 (Guanine Nucleotide Exchange Factors); 0 (RASGRP2 protein, human); 0CPP32S55X (Dimercaprol); 0HUR2WY345 (oxophenylarsine); 10465-78-8 (Diamide); 3FPU23BG52 (Toluene); EC 3.4.21.5 (Thrombin); EC 3.6.5.2 (rap1 GTP-Binding Proteins); U89B11P7SC (dithiol)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131220
[St] Status:MEDLINE
[do] DOI:10.1160/TH13-07-0629


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[PMID]:23760886
[Au] Autor:Beasley DM; Schep LJ; Slaughter RJ; Temple WA; Michel JM
[Ad] Endereço:National Poisons Centre, Department of Preventive and Social Medicine, University of Otago, P. O. Box 913, Dunedin, New Zealand.
[Ti] Título:Full recovery from a potentially lethal dose of mercuric chloride.
[So] Source:J Med Toxicol;10(1):40-4, 2014 Mar.
[Is] ISSN:1937-6995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Mercuric chloride poisoning is rare yet potentially life-threatening. We report a case of poisoning with a potentially significant amount of mercuric chloride which responded to aggressive management. CASE REPORT: A 19-year-old female presented to the Emergency Department with nausea, abdominal discomfort, vomiting of blood-stained fluid, and diarrhea following suicidal ingestion of 2-4 g of mercuric chloride powder. An abdominal radiograph showed radio-opaque material within the gastric antrum and the patient's initial blood mercury concentration was 17.9 µmol/L (or 3.58 mg/L) at 3 h post-ingestion. Given the potential toxicity of inorganic mercury, the patient was admitted to the intensive care unit and chelation with dimercaprol was undertaken. Further clinical effects included mild hemodynamic instability, acidosis, hypokalemia, leukocytosis, and fever. The patient's symptoms began to improve 48 h after admission and resolved fully within a week. DISCUSSION: Mercuric chloride has an estimated human fatal dose of between 1 and 4 g. Despite a reported ingestion of a potentially lethal dose and a high blood concentration, this patient experienced mild to moderate poisoning only and she responded to early and appropriate intervention. Mercuric chloride can produce a range of toxic effects including corrosive injury, severe gastrointestinal disturbances, acute renal failure, circulatory collapse, and eventual death. Treatment includes close observation and aggressive supportive care along with chelation, preferably with 2,3-dimercapto-1-propane sulfonate or 2,3-meso-dimercaptosuccinic acid.
[Mh] Termos MeSH primário: Indicadores e Reagentes/toxicidade
Cloreto de Mercúrio/toxicidade
Intoxicação por Mercúrio/tratamento farmacológico
Tentativa de Suicídio
[Mh] Termos MeSH secundário: Adulto
Quelantes/administração & dosagem
Quelantes/uso terapêutico
Terapia por Quelação
Dimercaprol/administração & dosagem
Dimercaprol/uso terapêutico
Feminino
Seres Humanos
Indicadores e Reagentes/química
Indicadores e Reagentes/farmacocinética
Injeções Intramusculares
Cloreto de Mercúrio/antagonistas & inibidores
Cloreto de Mercúrio/farmacocinética
Mercúrio/sangue
Mercúrio/química
Intoxicação por Mercúrio/sangue
Intoxicação por Mercúrio/terapia
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Indicators and Reagents); 0CPP32S55X (Dimercaprol); 53GH7MZT1R (Mercuric Chloride); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130614
[St] Status:MEDLINE
[do] DOI:10.1007/s13181-013-0311-1


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[PMID]:24191337
[Au] Autor:Mostafazadeh B; Kiani A; Mohamadi E; Shaki F; Shirazi FH
[Ad] Endereço:Department of Forensic Medicine and Toxicology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Mercury exposure of gold mining workers in the northwest of Iran.
[So] Source:Pak J Pharm Sci;26(6):1267-70, 2013 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Mercury exposure is a health concern in the occupational settings like gold mining and chloralkali industries and blood and urine levels of mercury are used as exposure indicators. In this study, blood and urine concentrations of mercury were determined using hydride generation atomic absorption spectrophotometery (HGAAS) in sixteen gold miners with neuropsychiatric symptoms. The patients treated with two chelating agents, dimercaprol and D-penicillamine. The mean serum mercury levels before and after chelation therapy were 208.14 µg/L(-1) and 10.50 µg/L(-1), respectively. The mean urinary mercury levels before and after chelation therapy were 134.70 µg/L(-1) and 17.23 µg/L(-1), respectively. The results of this study showed that there are significant differences between concentration of blood and urine mercury before and after intervention (p<0.005). There were no significant differences between in the biochemistry parameters of patients before and after treatment. This study indicated that the gold miners in the northwest of Iran had been exposed to high levels of mercury vapors [Hg((0))].
[Mh] Termos MeSH primário: Ouro
Mercúrio/efeitos adversos
Mineração
Exposição Ocupacional
[Mh] Termos MeSH secundário: Adulto
Dimercaprol/uso terapêutico
Seres Humanos
Irã (Geográfico)
Masculino
Mercúrio/sangue
Mercúrio/urina
Meia-Idade
Penicilamina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0CPP32S55X (Dimercaprol); 7440-57-5 (Gold); FXS1BY2PGL (Mercury); GNN1DV99GX (Penicillamine)
[Em] Mês de entrada:1401
[Cu] Atualização por classe:131105
[Lr] Data última revisão:
131105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131106
[St] Status:MEDLINE



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