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[PMID]:29227084
[Au] Autor:Gudkova OO; Latyshko NV; Shandrenko SG
[Ti] Título:Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats.
[So] Source:Ukr Biochem J;88(1):79-87, 2016 Jan-Feb.
[Is] ISSN:2409-4943
[Cp] País de publicação:Ukraine
[La] Idioma:eng
[Ab] Resumo:In this study we have tested an idea on the important role of amine oxidases (semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase) as an additional source of oxidative/carbonyl stress under glycerol-induced rhabdomyolysis, since the enhanced formation of reactive oxygen species and reactive carbonyl species in a variety of tissues is linked to various diseases. In our experiments we used the sensitive fluorescent method devised for estimation of amine oxidases activity in the rat kidney and thymus as targeted organs under rhabdomyolysis. We have found in vivo the multiple rises in activity of semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase (2-4.5 times) in the corresponding cell fractions, whole cells or their lysates at the 3-6th day after glycerol injection. Aberrant antioxidant activities depended on rhabdomyolysis stage and had organ specificity. Additional treatment of animals with metal chelator 'Unithiol' adjusted only the activity of antioxidant enzymes but not amine oxidases in both organs. Furthermore the in vitro experiment showed that Fenton reaction (hydrogen peroxide in the presence of iron) products alone had no effect on semicarbazide-sensitive amine oxidase activity in rat liver cell fraction whereas supplementation with methylglyoxal resulted in its significant 2.5-fold enhancement. Combined action of the both agents had additive effect on semicarbazide-sensitive amine oxidase activity. We can assume that biogenic amine and polyamine catabolism by amine oxidases is upregulated by oxidative and carbonyl stress factors directly under rhabdomyolysis progression, and the increase in catabolic products concentration contributes to tissue damage in glycerol-induced acute renal failure and apoptosis stimulation in thymus.
[Mh] Termos MeSH primário: Amina Oxidase (contendo Cobre)/metabolismo
Monoaminoxidase/metabolismo
Oxirredutases atuantes sobre Doadores de Grupo CH-NH/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Rabdomiólise/enzimologia
[Mh] Termos MeSH secundário: Animais
Quelantes/farmacologia
Glicerol
Hepatócitos/efeitos dos fármacos
Hepatócitos/enzimologia
Hepatócitos/patologia
Peróxido de Hidrogênio/antagonistas & inibidores
Peróxido de Hidrogênio/farmacologia
Rim/efeitos dos fármacos
Rim/enzimologia
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/enzimologia
Fígado/patologia
Masculino
Especificidade de Órgãos
Oxirredução
Carbonilação Proteica
Aldeído Pirúvico/antagonistas & inibidores
Aldeído Pirúvico/farmacologia
Ratos
Ratos Wistar
Rabdomiólise/induzido quimicamente
Rabdomiólise/tratamento farmacológico
Rabdomiólise/patologia
Semicarbazidas/antagonistas & inibidores
Semicarbazidas/farmacologia
Timo/efeitos dos fármacos
Timo/enzimologia
Timo/patologia
Unitiol/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Reactive Oxygen Species); 0 (Semicarbazides); 37QUC23K2X (carbamylhydrazine); 4076-02-2 (Unithiol); 722KLD7415 (Pyruvaldehyde); BBX060AN9V (Hydrogen Peroxide); EC 1.4.3.21 (Amine Oxidase (Copper-Containing)); EC 1.4.3.4 (Monoamine Oxidase); EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors); EC 1.5.3.- (polyamine oxidase); PDC6A3C0OX (Glycerol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.15407/ubj88.01.079


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[PMID]:28701428
[Au] Autor:Carter M; Abdi A; Naz F; Thabet F; Vyas A
[Ad] Endereço:Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan.
[Ti] Título:A Mercury Toxicity Case Complicated by Hyponatremia and Abnormal Endocrinological Test Results.
[So] Source:Pediatrics;140(2), 2017 Aug.
[Is] ISSN:1098-4275
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp. The child was initially managed in the outpatient setting, and the investigation was mainly targeted toward infectious etiology, including Rocky Mountain spotted fever and Lyme disease. He was eventually admitted to the hospital with altered mental status and was noted to have hyponatremia with serum sodium of 121 mEq/L. Thyroid studies also revealed elevated free thyroxine levels in the presence of normal triiodothyronine and thyrotropin. The patient developed hypertension and tachycardia, and was found to have elevated 24-hour vanillylmandelic acid and metanephrines. Finally, heavy metal measurements revealed a blood Hg level that was greater than the reference values of 0 to 9 ng/mL. Chelation treatment with 2,3-dimercaptopropane-1-sulfonate was subsequently initiated and over a period of 8 months his symptoms resolved and his thyroid function test returned to normal. This case highlights some of the challenges commonly encountered in identifying Hg exposure. More importantly, it illustrates that exposure to Hg should be considered in children who present with the symptoms and abnormal endocrinologic test results described in this report.
[Mh] Termos MeSH primário: Hipertireoxinemia/diagnóstico
Hiponatremia/diagnóstico
Intoxicação por Mercúrio/diagnóstico
Metanefrina/sangue
Doenças Raras
Ácido Vanilmandélico/sangue
[Mh] Termos MeSH secundário: Terapia por Quelação
Criança
Diagnóstico Diferencial
Seres Humanos
Hipertireoxinemia/etiologia
Hiponatremia/etiologia
Masculino
Intoxicação por Mercúrio/tratamento farmacológico
Admissão do Paciente
Unitiol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
4076-02-2 (Unithiol); 5001-33-2 (Metanephrine); 55-10-7 (Vanilmandelic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


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[PMID]:28380689
[Au] Autor:Bessonov K; Vassall KA; Harauz G
[Ad] Endereço:Systems and Modeling Unit, Montefiore Institute, Université de Liège, Quartier Polytech 1, Allée de la Découverte 10, Liège, 4000, Belgium.
[Ti] Título:Docking and molecular dynamics simulations of the Fyn-SH3 domain with free and phospholipid bilayer-associated 18.5-kDa myelin basic protein (MBP)-Insights into a noncanonical and fuzzy interaction.
[So] Source:Proteins;85(7):1336-1350, 2017 Jul.
[Is] ISSN:1097-0134
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The molecular details of the association between the human Fyn-SH3 domain, and the fragment of 18.5-kDa myelin basic protein (MBP) spanning residues S38-S107 (denoted as xα2-peptide, murine sequence numbering), were studied in silico via docking and molecular dynamics over 50-ns trajectories. The results show that interaction between the two proteins is energetically favorable and heavily dependent on the MBP proline-rich region (P93-P98) in both aqueous and membrane environments. In aqueous conditions, the xα2-peptide/Fyn-SH3 complex adopts a "sandwich""-like structure. In the membrane context, the xα2-peptide interacts with the Fyn-SH3 domain via the proline-rich region and the ß-sheets of Fyn-SH3, with the latter wrapping around the proline-rich region in a form of a clip. Moreover, the simulations corroborate prior experimental evidence of the importance of upstream segments beyond the canonical SH3-ligand. This study thus provides a more-detailed glimpse into the context-dependent interaction dynamics and importance of the ß-sheets in Fyn-SH3 and proline-rich region of MBP. Proteins 2017; 85:1336-1350. © 2017 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Bicamadas Lipídicas/química
Proteína Básica da Mielina/química
Proteínas Proto-Oncogênicas c-fyn/química
Água/química
Domínios de Homologia de src
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sítios de Ligação
Dimiristoilfosfatidilcolina/química
Seres Humanos
Camundongos
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
Peptídeos/química
Fosforilcolina/análogos & derivados
Fosforilcolina/química
Prolina/química
Ligação Proteica
Conformação Proteica em alfa-Hélice
Conformação Proteica em Folha beta
Estrutura Terciária de Proteína
Termodinâmica
Unitiol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (Myelin Basic Protein); 0 (Peptides); 059QF0KO0R (Water); 107-73-3 (Phosphorylcholine); 4076-02-2 (Unithiol); 53949-18-1 (dodecylphosphocholine); 9DLQ4CIU6V (Proline); EC 2.7.10.2 (FYN protein, human); EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn); U86ZGC74V5 (Dimyristoylphosphatidylcholine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1002/prot.25295


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[PMID]:28102816
[Au] Autor:Niu HX; Li SH; Li HY; Chen YH; Liu WW; Li PL; Long HB
[Ti] Título:Clinicopathological features, diagnosis, and treatment of IgA nephropathy with minimal change disease related to exposure to mercury-containing cosmetics: a case report
.
[So] Source:Clin Nephrol;87 (2017)(4):196-201, 2017 Apr.
[Is] ISSN:0301-0430
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:AIM: Membranous nephropathy and minimal change disease (MCD) have been involved in mercury-induced nephrotic syndrome. IgA nephropathy is not known to be a common pathological type. In the present article, we report a case of IgA nephropathy with MCD following exposure to mercury-containing skin lightening cream. MATERIAL AND METHODS: The patient was a 39-year-old woman who presented with nephrotic syndrome. She had a 6-month history of using as many as 8 kinds of skin-lightening creams, and urinary mercury excretion was high. Renal biopsy revealed IgA nephropathy with MCD. The use of cosmetics was stopped and chelation therapy was given. After 4 courses (1 month) of chelation therapy, there was a complete remission of proteinuria and hematuria, and urine tests remained normal during the 5-year follow-up period. RESULTS AND CONCLUSIONS: The unique clinical and pathological features of IgA nephropathy with MCD had raised the controversial question of whether MCD and IgA deposition are separate entities or a common pathophysiology. Repeated renal biopsy and similar cases were helpful and should be carried out as far as possible.
.
[Mh] Termos MeSH primário: Glomerulonefrite por IGA/induzido quimicamente
Intoxicação por Mercúrio/complicações
Nefrose Lipoide/induzido quimicamente
Preparações Clareadoras de Pele/envenenamento
[Mh] Termos MeSH secundário: Adulto
Quelantes/uso terapêutico
Feminino
Glomerulonefrite por IGA/patologia
Glomerulonefrite por IGA/terapia
Hematúria/etiologia
Seres Humanos
Rim/patologia
Rim/ultraestrutura
Intoxicação por Mercúrio/tratamento farmacológico
Nefrose Lipoide/patologia
Nefrose Lipoide/terapia
Síndrome Nefrótica/etiologia
Síndrome Nefrótica/terapia
Proteinúria/etiologia
Indução de Remissão
Preparações Clareadoras de Pele/química
Unitiol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 0 (Skin Lightening Preparations); 4076-02-2 (Unithiol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.5414/CN108967


  5 / 527 MEDLINE  
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[PMID]:28027882
[Au] Autor:Gao Z; Ying X; Yan J; Wang J; Cai S; Yan C
[Ad] Endereço:Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
[Ti] Título:Acute mercury vapor poisoning in a 3-month-old infant: A case report.
[So] Source:Clin Chim Acta;465:119-122, 2017 Feb.
[Is] ISSN:1873-3492
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We investigated the clinical characteristics of a 3-month-old infant with acute mercury vapor poisoning. Clinical symptoms of acute mercury poisoning in infants include acute onset, rapid progression, severe illness with respiratory symptoms that may result in pneumothoraces and aspiration pneumonias. CASE PRESENTATION: A 3-month-old girl presented with pneumothoraces and respiratory failure to the hospital. Two days before hospitalization, the girl had stayed in a room containing mercury vapor for several hours. She was hospitalized for acute mercury poisoning. We used sodium dimercaptosulphonate (DMPS) for treatment. CONCLUSION: Pulmonary disease was mainly induced by the inhalation of mercury vapor. The disease was characterized by acute respiratory distress, pneumothorax and acute chemical pneumonitis. It responded to chelation therapy with the agent DMPS.
[Mh] Termos MeSH primário: Intoxicação por Mercúrio/tratamento farmacológico
Intoxicação por Mercúrio/etiologia
[Mh] Termos MeSH secundário: Quelantes/uso terapêutico
Feminino
Seres Humanos
Lactente
Mercúrio/química
Mercúrio/toxicidade
Unitiol/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chelating Agents); 4076-02-2 (Unithiol); FXS1BY2PGL (Mercury)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161229
[St] Status:MEDLINE


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[PMID]:27271668
[Au] Autor:Wee J; Day DM; Linz JE
[Ad] Endereço:Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA. jmw544@cornell.edu.
[Ti] Título:Effects of Zinc Chelators on Aflatoxin Production in Aspergillus parasiticus.
[So] Source:Toxins (Basel);8(6), 2016 06 02.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Zinc concentrations strongly influence aflatoxin accumulation in laboratory media and in food and feed crops. The presence of zinc stimulates aflatoxin production, and the absence of zinc impedes toxin production. Initial studies that suggested a link between zinc and aflatoxin biosynthesis were presented in the 1970s. In the present study, we utilized two zinc chelators, N,N,N',N'-tetrakis (2-pyridylmethyl) ethane-1,2-diamine (TPEN) and 2,3-dimercapto-1-propanesulfonic acid (DMPS) to explore the effect of zinc limitation on aflatoxin synthesis in Aspergillus parasiticus. TPEN but not DMPS decreased aflatoxin biosynthesis up to six-fold depending on whether A. parasiticus was grown on rich or minimal medium. Although we observed significant inhibition of aflatoxin production by TPEN, no detectable changes were observed in expression levels of the aflatoxin pathway gene ver-1 and the zinc binuclear cluster transcription factor, AflR. Treatment of growing A. parasiticus solid culture with a fluorescent zinc probe demonstrated an increase in intracellular zinc levels assessed by increases in fluorescent intensity of cultures treated with TPEN compared to controls. These data suggest that TPEN binds to cytoplasmic zinc therefore limiting fungal access to zinc. To investigate the efficacy of TPEN on food and feed crops, we found that TPEN effectively decreases aflatoxin accumulation on peanut medium but not in a sunflower seeds-derived medium. From an application perspective, these data provide the basis for biological differences that exist in the efficacy of different zinc chelators in various food and feed crops frequently contaminated by aflatoxin.
[Mh] Termos MeSH primário: Aflatoxinas/biossíntese
Aspergillus/efeitos dos fármacos
Quelantes/farmacologia
Etilenodiaminas/farmacologia
[Mh] Termos MeSH secundário: Aflatoxinas/genética
Arachis
Aspergillus/genética
Aspergillus/metabolismo
Sementes
Fatores de Transcrição
Unitiol/farmacologia
Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Chelating Agents); 0 (Ethylenediamines); 0 (Transcription Factors); 4076-02-2 (Unithiol); J41CSQ7QDS (Zinc); R9PTU1U29I (N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:27074988
[Au] Autor:Alexander M
[Ad] Endereço:INS Chief Executive Officer Editor, Journal of Infusion Nursing.
[Ti] Título:A Culture of Safety: It Starts With You.
[So] Source:J Infus Nurs;39(3):125-6, 2016 May-Jun.
[Is] ISSN:1539-0667
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Infusões Intravenosas/métodos
Infusões Intravenosas/normas
Papel do Profissional de Enfermagem
Segurança do Paciente/normas
Guias de Prática Clínica como Assunto
Gestão da Segurança/métodos
[Mh] Termos MeSH secundário: American Nurses' Association
Seres Humanos
Unitiol
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
4076-02-2 (Unithiol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170314
[Lr] Data última revisão:
170314
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1097/NAN.0000000000000171


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[PMID]:26934592
[Au] Autor:Tang J; Alsop RJ; Backholm M; Dies H; Shi AC; Rheinstädter MC
[Ad] Endereço:Department of Physics and Astronomy, McMaster University, ABB-241, 1280 Main Street West, Hamilton, Ontario L8S 4M1, Canada. rheinstadter@mcmaster.ca.
[Ti] Título:Amyloid-ß(25-35) peptides aggregate into cross-ß sheets in unsaturated anionic lipid membranes at high peptide concentrations.
[So] Source:Soft Matter;12(13):3165-76, 2016 Apr 07.
[Is] ISSN:1744-6848
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:One of the hallmarks of Alzheimer's disease is the formation of protein plaques in the brain, which mainly consist of amyloid-ß peptides of different lengths. While the role of these plaques in the pathology of the disease is not clear, the mechanism behind peptide aggregation is a topic of intense research and discussion. Because of their simplicity, synthetic membranes are promising model systems to identify the elementary processes involved. We prepared unsaturated zwitterionic/anionic lipid membranes made of 1-palmitoyl-2-oleoyl-sn-glycero-phosphocholine (POPC) and 1,2-dimyristoyl-sn-glycero-3-phospho-l-serine (DMPS) at concentrations of POPC/3 mol% DMPS containing 0 mol%, 3 mol%, 10 mol%, and 20 mol% amyloid-ß25-35 peptides. Membrane-embedded peptide clusters were observed at peptide concentrations of 10 and 20 mol% with a typical cluster size of ∼11 µm. Cluster density increased with peptide concentration from 59 (±3) clusters per mm(2) to 920 (±64) clusters per mm(2), respectively. While monomeric peptides take an α-helical state when embedded in lipid bilayers at low peptide concentrations, the peptides in peptide clusters were found to form cross-ß sheets and showed the characteristic pattern in X-ray experiments. The presence of the peptides was accompanied by an elastic distortion of the bilayers, which can induce a long range interaction between the peptides. The experimentally observed cluster patterns agree well with Monte Carlo simulations of long-range interacting peptides. This interaction may be the fundamental process behind cross-ß sheet formation in membranes and these sheets may serve as seeds for further growth into amyloid fibrils.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/química
Bicamadas Lipídicas/química
Fragmentos de Peptídeos/química
[Mh] Termos MeSH secundário: Peptídeos beta-Amiloides/metabolismo
Ânions/química
Bicamadas Lipídicas/metabolismo
Microscopia
Método de Monte Carlo
Fragmentos de Peptídeos/metabolismo
Fosfatidilcolinas/química
Estrutura Secundária de Proteína
Unitiol/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Anions); 0 (Lipid Bilayers); 0 (Peptide Fragments); 0 (Phosphatidylcholines); 0 (amyloid beta-protein (25-35)); 4076-02-2 (Unithiol); TE895536Y5 (1-palmitoyl-2-oleoylphosphatidylcholine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160303
[St] Status:MEDLINE
[do] DOI:10.1039/c5sm02619a


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[PMID]:26646730
[Au] Autor:Barrett MA; Trapp M; Lohstroh W; Seydel T; Ollivier J; Ballauff M; Dencher NA; Hauß T
[Ad] Endereço:Helmholtz-Zentrum Berlin für Materialien und Energie, Lise-Meitner-Campus, Berlin, Germany. hauss@helmholtz-berlin.de.
[Ti] Título:Alzheimer's peptide amyloid-ß, fragment 22-40, perturbs lipid dynamics.
[So] Source:Soft Matter;12(5):1444-51, 2016 Feb 07.
[Is] ISSN:1744-6848
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The peptide amyloid-ß (Aß) interacts with membranes of cells in the human brain and is associated with Alzheimer's disease (AD). The intercalation of Aß in membranes alters membrane properties, including the structure and lipid dynamics. Any change in the membrane lipid dynamics will affect essential membrane processes, such as energy conversion, signal transduction and amyloid precursor protein (APP) processing, and may result in the observed neurotoxicity associated with the disease. The influence of this peptide on membrane dynamics was studied with quasi-elastic neutron scattering, a technique which allows a wide range of observation times from picoseconds to nanoseconds, over nanometer length scales. The effect of the membrane integral neurotoxic peptide amyloid-ß, residues 22-40, on the in- and out-of-plane lipid dynamics was observed in an oriented DMPC/DMPS bilayer at 15 °C, in its gel phase, and at 30 °C, near the phase transition temperature of the lipids. Near the phase-transition temperature, a 1.5 mol% of peptide causes up to a twofold decrease in the lipid diffusion coefficients. In the gel-phase, this effect is reversed, with amyloid-ß(22-40) increasing the lipid diffusion coefficients. The observed changes in lipid diffusion are relevant to protein-protein interactions, which are strongly influenced by the diffusion of membrane components. The effect of the amyloid-ß peptide fragment on the diffusion of membrane lipids will provide insight into the membrane's role in AD.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/metabolismo
Bicamadas Lipídicas/metabolismo
[Mh] Termos MeSH secundário: Doença de Alzheimer/metabolismo
Doença de Alzheimer/patologia
Peptídeos beta-Amiloides/química
Difusão
Dimiristoilfosfatidilcolina/química
Seres Humanos
Bicamadas Lipídicas/química
Domínios e Motivos de Interação entre Proteínas
Unitiol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Lipid Bilayers); 4076-02-2 (Unithiol); U86ZGC74V5 (Dimyristoylphosphatidylcholine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151210
[St] Status:MEDLINE
[do] DOI:10.1039/c5sm02026c


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[PMID]:26451711
[Au] Autor:Korchowiec B; Gorczyca M; Rogalska E; Regnouf-de-Vains JB; Mourer M; Korchowiec J
[Ad] Endereço:Department of Physical Chemistry and Electrochemistry, Faculty of Chemistry, Jagiellonian University, ul. R. Ingardena 3, 30-060 Krakow, Poland. bkorch@chemia.uj.edu.pl.
[Ti] Título:The selective interactions of cationic tetra-p-guanidinoethylcalix[4]arene with lipid membranes: theoretical and experimental model studies.
[So] Source:Soft Matter;12(1):181-90, 2016 Jan 07.
[Is] ISSN:1744-6848
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Behavior of cationic tetra-p-guanidinoethylcalix[4]arene (CX1) and its building block, p-guanidinoethylphenol (mCX1) in model monolayer lipid membranes was investigated using all atom molecular dynamics simulations and surface pressure measurements. Members of two classes of lipids were taken into account: zwitterionic 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and anionic 1,2-dimyristoyl-sn-glycero-3-phospho-l-serine sodium salt (DMPS) as models of eukaryotic and bacterial cell membranes, respectively. It was demonstrated that CX1 and mCX1 accumulate near the negatively charged DMPS monolayers. The adsorption to neutral monolayers was negligible. In contrast to mCX1, CX1 penetrated into the hydrophobic part of the monolayer. The latter effect, which is possible due to a flip-flop inversion of the CX1 orientation in the lipid layer compared to the aqueous phase, may be responsible for its antibacterial activity.
[Mh] Termos MeSH primário: Calixarenos/química
Bicamadas Lipídicas/química
Simulação de Dinâmica Molecular
[Mh] Termos MeSH secundário: Dimiristoilfosfatidilcolina/química
Interações Hidrofóbicas e Hidrofílicas
Unitiol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (para-guanidinoethylcalix(4)arene); 130036-26-9 (Calixarenes); 4076-02-2 (Unithiol); U86ZGC74V5 (Dimyristoylphosphatidylcholine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151010
[St] Status:MEDLINE
[do] DOI:10.1039/c5sm01891a



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