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[PMID]:28530186
[Au] Autor:Avinash B; Venu R; Prasad TNVKV; Alpha Raj M; Srinivasa Rao K; Srilatha C
[Ad] Endereço:Department of Veterinary Parasitology, Sri Venkateswara Veterinary University, College of Veterinary Science, Tirupati-517502, Andhra Pradesh, India.
[Ti] Título:Synthesis and characterisation of neem leaf extract, 2, 3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications.
[So] Source:IET Nanobiotechnol;11(4):383-389, 2017 Jun.
[Is] ISSN:1751-8741
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The utility of green silver nanoparticles (AgNPs) in veterinary medicine is steadily increasing as they have many therapeutic applications against pathogens and arthropods of livestock. In this study, green AgNPs using neem (N-AgNPs), 2,3-dehydrosalanol (2,3-DHS-AgNPs) and quercetin dihydrate (QDH-AgNPs) were synthesised and characterised. Synthesised compounds were characterised by UV-Vis spectroscopy and the peak absorbance was recorded at 370 nm for neem extract. For N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs, the maximum absorbance peaks were at 430, 230 and 220 nm, respectively. The FTIR analysis confirmed the synthesis of green AgNPs. The XRD pattern of N-AgNPs showed the peaks corresponding to whole spectra of 2 values ranging from 10-80. The relatively higher intensity of (111, 222) planes in face centred cubic crystalline structure supports the formation of synthesised AgNPs. In DLS analysis, the hydrodynamic diameter of neem leaf extract was found to be 259.8 nm, followed by 5.3, 6.7 and 261.8 nm for 2,3-DHS-AgNPs, N-AgNPs and QDH-AgNPs, respectively. Based on the transmission electron microscopy and scanning electron microscopy image analyses, confirmed the formation of N-AgNPs, 2,3-DHS-AgNPs and QDH-AgNPs. These eco-friendly phyto-AgNPs may be of use as an effective alternative to chemical control methods against the arthropods of livestock.
[Mh] Termos MeSH primário: Acaricidas/administração & dosagem
Azadirachta/química
Benzotiadiazinas/administração & dosagem
Nanopartículas Metálicas/administração & dosagem
Quercetina/administração & dosagem
Prata/administração & dosagem
[Mh] Termos MeSH secundário: Acaricidas/química
Benzotiadiazinas/química
Química Verde/métodos
Teste de Materiais
Nanopartículas Metálicas/química
Nanopartículas Metálicas/ultraestrutura
Tamanho da Partícula
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Benzothiadiazines); 0 (Plant Extracts); 3M4G523W1G (Silver); 9IKM0I5T1E (Quercetin); EZN4D2O31B (dehydrosanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1049/iet-nbt.2016.0095


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[PMID]:27913070
[Au] Autor:Oliveira JM; Galhano V; Henriques I; Soares AM; Loureiro S
[Ad] Endereço:Department of Biology & CESAM, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: jacinta.bio@gmail.com.
[Ti] Título:Basagran induces developmental malformations and changes the bacterial community of zebrafish embryos.
[So] Source:Environ Pollut;221:52-63, 2017 Feb.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to assess the effects of Basagran on zebrafish (Danio rerio) embryos. The embryos were exposed to Basagran at concentrations ranging from 120.0 to 480.6 mg/L, and the effects on embryo development (up to 96 h) and bacterial communities of 96 h-larvae were assessed. The embryo development response was time-dependent and concentration-dependent (106.35 < EC < 421.58 mg/L). The sensitivity of embryo-related endpoints decreased as follows: blood clotting in the head and/or around the yolk sac > delay or anomaly in yolk sac absorption > change in swimming equilibrium > development of pericardial and/or yolk sac oedema > scoliosis. A PCR-DGGE analysis was used to evaluate changes in the structure, richness, evenness and diversity of bacterial communities after herbicide exposure. A herbicide-induced structural adjustment of bacterial community was observed. In this study, it was successfully demonstrated that Basagran affected zebrafish embryos and associated bacterial communities, showing time-dependent and concentration-dependent embryos' developmental response and structural changes in bacterial community. Thus, this work provides for the first time a complementary approach, which is useful to derive robust toxicity thresholds considering the embryo-microbiota system as a whole. The aquatic hazard assessment will be strengthened by combining current ecotoxicological tests with molecular microbiology tools.
[Mh] Termos MeSH primário: Bactérias/efeitos dos fármacos
Benzotiadiazinas/toxicidade
Embrião não Mamífero/microbiologia
Herbicidas/toxicidade
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Embrião não Mamífero/efeitos dos fármacos
Desenvolvimento Embrionário/efeitos dos fármacos
Larva
Natação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzothiadiazines); 0 (Herbicides); R4S7ZGZ9CT (bentazone)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE


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[PMID]:27751572
[Au] Autor:Skeff W; Orlikowska A; Schulz-Bull DE
[Ad] Endereço:Leibniz Institute for Baltic Sea Research Warnemuende, Department of Marine Chemistry, Seestrasse 15, 18119 Rostock, Germany. Electronic address: wael.skeff@io-warnemuende.de.
[Ti] Título:Methods comparison, transport and distribution of polar herbicides in the Baltic Sea.
[So] Source:Mar Pollut Bull;114(2):1110-1117, 2017 Jan 30.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two LC-MS/MS methods including different sample preparation and quantitative processes showed a good agreement for analysis of the herbicides MCPA, mecoprop, isoproturon, bentazon and chloridazon, and the metabolite chloridazon-methyl-desphenyl (CMD) in estuarine waters. Due to different sensitivity of the methods only one could be used to analyze marine samples. The transport of these compounds to the Baltic Sea via ten German estuaries and their distribution between coastal water and sediments was studied. The results showed that all selected compounds can be transported to the Baltic Sea (0.9-747ng/L). Chloridazon, bentazon, isoproturon and CMD were detected (0.9-8.9ng/L) in the coastal waters and chloridazon and isorproturon in the sediments (5-136pg/g d.w.). Levels of contaminants in the sediments could be influenced by the total organic carbon content. Concentrations observed in the Baltic Sea are most likely not high enough to cause acute effects, but long term effect studies are strongly recommended.
[Mh] Termos MeSH primário: Cromatografia Líquida/métodos
Herbicidas/análise
Espectrometria de Massas em Tandem/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Ácido 2-Metil-4-clorofenoxiacético/análogos & derivados
Ácido 2-Metil-4-clorofenoxiacético/análise
Países Bálticos
Benzotiadiazinas/análise
Monitoramento Ambiental/métodos
Estuários
Sedimentos Geológicos/análise
Herbicidas/química
Compostos de Fenilureia/análise
Piridazinas/análise
Água do Mar/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzothiadiazines); 0 (Herbicides); 0 (Phenylurea Compounds); 0 (Pyridazines); 0 (Water Pollutants, Chemical); 26X5RK7X7W (pyrazon); 66066K098P (isoproturon); 74N8TKR9P8 (mecoprop); D888C394VO (2-Methyl-4-chlorophenoxyacetic Acid); R4S7ZGZ9CT (bentazone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


  4 / 2627 MEDLINE  
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[PMID]:27666976
[Au] Autor:Sales PM; de Andrade LM; Pitcher MR; Rola FH; Gondim FA
[Ad] Endereço:Department of Anatomy and Morphofunctional Sciences, MSc Program, Universidade Federal do Ceará, Fortaleza, Brazil; Universidade Federal do Ceará, Fortaleza, Brazil; Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA.
[Ti] Título:Levodopa enhances immobility induced by spinal cord electromagnetic stimulation in rats.
[So] Source:Neurosci Lett;633:196-201, 2016 10 28.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The repetitive ElectroMagnetic Stimulation (rEMS) is an innocuous method applied to modulate neurocircuits in real-time to study the physiology of the central nervous system and treat neuropsychiatric conditions. Preliminary data suggest that spinal rEMS induces behavioral changes in awake rats. However, the mechanisms behind this phenomenon remain largely unknown. METHODS: Twenty-five male Wistar rats were divided into five subgroups of five animals each: one subgroup was drug-free, two subgroups received Levodopa+Benserazide 250+25mg/kg for two or seven days, and the remaining two subgroups received Haloperidol 0.1 or 0.3mg/kg for two days. The animals were restrained during sham rEMS (day 1) followed by real rEMS of the cervicothoracic region at a different day (day 2 or 7, depending on subgroup). Four behavioral parameters were quantified: Walking, Climbing, Grooming, and Cornering. RESULTS: rEMS reduced Walking and increased Cornering duration when applied over the cervicothoracic region of drug-free animals. A pretreatment with Levodopa+Benserazide for two or seven days induced an additional decrease in Walking after rEMS. This reduction was maximum after the treatment for seven days and associated with extinction of Climbing and increase in Cornering. A pretreatment with Haloperidol 0.1mg/kg reduced Grooming after rEMS, but did not prevent the reduction in Walking. CONCLUSIONS: Cervicothoracic rEMS induced complex immobility responses that are in part modulated by dopaminergic pathways in rats. Further studies are necessary to determine the specific mechanisms involved.
[Mh] Termos MeSH primário: Comportamento Animal
Dopaminérgicos/farmacologia
Levodopa/farmacologia
Medula Espinal/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Benzotiadiazinas/farmacologia
Interações Medicamentosas
Campos Eletromagnéticos
Asseio Animal/efeitos dos fármacos
Masculino
Atividade Motora/efeitos dos fármacos
Ratos Wistar
Comportamento Estereotipado/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzothiadiazines); 0 (Dopamine Agents); 1TD8J48L61 (benzothiazide); 46627O600J (Levodopa)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:27663136
[Au] Autor:Barygin OI
[Ad] Endereço:I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, 194223, Torez pr. 44, Saint-Petersburg, Russia. Electronic address: Oleg_Barygin@mail.ru.
[Ti] Título:Inhibition of calcium-permeable and calcium-impermeable AMPA receptors by perampanel in rat brain neurons.
[So] Source:Neurosci Lett;633:146-151, 2016 10 28.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Perampanel is an antiepileptic drug that is used to treat partial-onset seizures and generalized tonic-clonic seizures. It is a highly selective AMPA receptor allosteric antagonist. However, published data on perampanel activity vary in different studies. In the present work we studied the inhibition of native calcium-permeable and calcium-impermeable AMPA receptors in rat brain neurons by perampanel using whole-cell patch clamp technique. We found that inhibitory activity and kinetics of perampanel action do not differ between calcium-permeable AMPA receptors of rat giant striatum interneurons and calcium-impermeable receptors of hippocampal CA1 pyramidal neurons (the IC value about 60nM). Also, perampanel caused the same inhibition of steady-state currents induced by kainate and glutamate. From the other side perampanel-induced inhibition was markedly reduced in the presence of cyclothiazide (IC value increased to 1.2±0.2µM). We demonstrated that perampanel competes with GYKI-52466 for binding site.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Encéfalo/efeitos dos fármacos
Cálcio/metabolismo
Neurônios/efeitos dos fármacos
Piridonas/farmacologia
Receptores de AMPA/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Benzodiazepinas/farmacologia
Benzotiadiazinas/farmacologia
Sítios de Ligação
Encéfalo/metabolismo
Região CA1 Hipocampal/efeitos dos fármacos
Região CA1 Hipocampal/metabolismo
Corpo Estriado/efeitos dos fármacos
Corpo Estriado/metabolismo
Interações Medicamentosas
Ácido Glutâmico/farmacologia
Interneurônios/efeitos dos fármacos
Interneurônios/metabolismo
Ácido Caínico/farmacologia
Neurônios/metabolismo
Células Piramidais/efeitos dos fármacos
Células Piramidais/metabolismo
Ratos Wistar
Receptores de AMPA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Benzothiadiazines); 0 (Pyridones); 0 (Receptors, AMPA); 102771-26-6 (GYKI 52466); 12794-10-4 (Benzodiazepines); 3KX376GY7L (Glutamic Acid); H821664NPK (perampanel); P71U09G5BW (cyclothiazide); SIV03811UC (Kainic Acid); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  6 / 2627 MEDLINE  
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[PMID]:27398547
[Au] Autor:Jung D; Thirupathaiah B; Lee E; Kwon G; Kim C; Seo S
[Ti] Título:Synthesis and Characterization of Benzothiadiazole Derivatives as Organic Semiconductors for Organic Thin-Film Transistors.
[So] Source:J Nanosci Nanotechnol;16(1):924-9, 2016 Jan.
[Is] ISSN:1533-4880
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:New benzothiadiazole derivatives end-functionalized with carbazole and a-carboline, 4,7-di(9H-carbazol-9-yl)benzo[c][1,2,5]thiadiazole (1) and 4-(9H-carbazol-9-yl)-7-(9H-pyrido[2,3-bindol-9-yl) benzo[c][1,2,5]thiadiazole (2) were synthesized and characterized as organic semiconductors for organic thin-film transistors (OTFTs). Thermal, optical, and electrochemical properties of the corresoponding compounds were characterized. Thin films of compound 1 exhibited p-channel characteristics with carrier mobility as high as 10⁻4 cm²/Vs and a current on/off ratio of 105 for top-contact/bottom-gate OTFT devices.
[Mh] Termos MeSH primário: Benzotiadiazinas/química
Técnicas Eletroquímicas
Transistores Eletrônicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzothiadiazines)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160711
[Lr] Data última revisão:
160711
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


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[PMID]:27276258
[Au] Autor:Krintel C; Francotte P; Pickering DS; Juknaite L; Pøhlsgaard J; Olsen L; Frydenvang K; Goffin E; Pirotte B; Kastrup JS
[Ad] Endereço:Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[Ti] Título:Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.
[So] Source:Biophys J;110(11):2397-2406, 2016 Jun 07.
[Is] ISSN:1542-0086
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The 1,2,4-benzothiadiazine 1,1-dioxide type of positive allosteric modulators of the ionotropic glutamate receptor A2 (GluA2) are promising lead compounds for the treatment of cognitive disorders, e.g., Alzheimer's disease. The modulators bind in a cleft formed by the interface of two neighboring ligand binding domains and act by stabilizing the agonist-bound open-channel conformation. The driving forces behind the binding of these modulators can be significantly altered with only minor substitutions to the parent molecules. In this study, we show that changing the 7-fluorine substituent of modulators BPAM97 (2) and BPAM344 (3) into a hydroxyl group (BPAM557 (4) and BPAM521 (5), respectively), leads to a more favorable binding enthalpy (ΔH, kcal/mol) from -4.9 (2) and -7.5 (3) to -6.2 (4) and -14.5 (5), but also a less favorable binding entropy (-TΔS, kcal/mol) from -2.3 (2) and -1.3 (3) to -0.5 (4) and 4.8 (5). Thus, the dissociation constants (Kd, µM) of 4 (11.2) and 5 (0.16) are similar to those of 2 (5.6) and 3 (0.35). Functionally, 4 and 5 potentiated responses of 10 µM L-glutamate at homomeric rat GluA2(Q)i receptors with EC50 values of 67.3 and 2.45 µM, respectively. The binding mode of 5 was examined with x-ray crystallography, showing that the only change compared to that of earlier compounds was the orientation of Ser-497 pointing toward the hydroxyl group of 5. The favorable enthalpy can be explained by the formation of a hydrogen bond from the side-chain hydroxyl group of Ser-497 to the hydroxyl group of 5, whereas the unfavorable entropy might be due to desolvation effects combined with a conformational restriction of Ser-497 and 5. In summary, this study shows a remarkable example of enthalpy-entropy compensation in drug development accompanied with a likely explanation of the underlying structural mechanism.
[Mh] Termos MeSH primário: Fármacos atuantes sobre Aminoácidos Excitatórios/química
Fármacos atuantes sobre Aminoácidos Excitatórios/farmacologia
Receptores de AMPA/metabolismo
[Mh] Termos MeSH secundário: Animais
Benzotiadiazinas/química
Benzotiadiazinas/farmacologia
Calorimetria
Simulação por Computador
Cristalografia por Raios X
Óxidos S-Cíclicos/síntese química
Óxidos S-Cíclicos/química
Óxidos S-Cíclicos/farmacologia
Descoberta de Drogas
Entropia
Fármacos atuantes sobre Aminoácidos Excitatórios/síntese química
Ácido Glutâmico/metabolismo
Ácido Glutâmico/farmacologia
Modelos Moleculares
Estrutura Molecular
Oócitos
Ligação Proteica
Multimerização Proteica
Ratos
Receptores de AMPA/genética
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Tiazinas/síntese química
Tiazinas/química
Tiazinas/farmacologia
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide); 0 (BPAM344); 0 (BPAM521); 0 (BPAM577); 0 (Benzothiadiazines); 0 (Cyclic S-Oxides); 0 (Excitatory Amino Acid Agents); 0 (Receptors, AMPA); 0 (Recombinant Proteins); 0 (Thiazines); 0 (glutamate receptor ionotropic, AMPA 2); 3KX376GY7L (Glutamic Acid)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170827
[Lr] Data última revisão:
170827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


  8 / 2627 MEDLINE  
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[PMID]:27273633
[Au] Autor:Plested AJ
[Ad] Endereço:Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, Germany.
[Ti] Título:Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels.
[So] Source:Nat Struct Mol Biol;23(6):494-502, 2016 Jun 07.
[Is] ISSN:1545-9985
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ion channels gated by neurotransmitters are present across metazoans, in which they are essential for brain function, sensation and locomotion; closely related homologs are also found in bacteria. Structures of eukaryotic pentameric cysteine-loop (Cys-loop) receptors and tetrameric ionotropic glutamate receptors in multiple functional states have recently become available. Here, I describe how these studies relate to established ideas regarding receptor activation and how they have enabled decades' worth of functional work to be pieced together, thus allowing previously puzzling aspects of receptor activity to be understood.
[Mh] Termos MeSH primário: Receptores de Canais Iônicos de Abertura Ativada por Ligante com Alça de Cisteína/química
Canais Iônicos/química
Neurotransmissores/metabolismo
Receptores de Glutamato/química
Sinapses/metabolismo
Transmissão Sináptica/fisiologia
[Mh] Termos MeSH secundário: Animais
Bactérias/química
Bactérias/metabolismo
Benzotiadiazinas/farmacologia
Cognição/efeitos dos fármacos
Cognição/fisiologia
Receptores de Canais Iônicos de Abertura Ativada por Ligante com Alça de Cisteína/genética
Receptores de Canais Iônicos de Abertura Ativada por Ligante com Alça de Cisteína/metabolismo
Expressão Gênica
Seres Humanos
Ativação do Canal Iônico/efeitos dos fármacos
Canais Iônicos/genética
Canais Iônicos/metabolismo
Ivermectina/farmacologia
Locomoção/efeitos dos fármacos
Locomoção/fisiologia
Modelos Moleculares
Percepção/efeitos dos fármacos
Percepção/fisiologia
Piperidinas/farmacologia
Receptores de Glutamato/genética
Receptores de Glutamato/metabolismo
Sinapses/efeitos dos fármacos
Transmissão Sináptica/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzothiadiazines); 0 (Cysteine Loop Ligand-Gated Ion Channel Receptors); 0 (Ion Channels); 0 (Neurotransmitter Agents); 0 (Piperidines); 0 (Receptors, Glutamate); 70288-86-7 (Ivermectin); P71U09G5BW (cyclothiazide); R8OE3P6O5S (ifenprodil)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170607
[Lr] Data última revisão:
170607
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1038/nsmb.3214


  9 / 2627 MEDLINE  
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[PMID]:27240385
[Au] Autor:Feng X; Yu J; Pan L; Song G; Zhang H
[Ad] Endereço:College of Science, China Agricultural University, Beijing 100193, China. xxf0423@cau.edu.cn.
[Ti] Título:Dissipation and Residues of Dichlorprop-P and Bentazone in Wheat-Field Ecosystem.
[So] Source:Int J Environ Res Public Health;13(6), 2016 May 26.
[Is] ISSN:1660-4601
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Dichlorprop-P and bentazone have been widely used in the prevention and control of weeds in wheat field ecosystems. There is a concern that pesticide residues and metabolites remain on or in the wheat. Thus, the study of the determination and monitoring of their residues in wheat has important significance. A rapid, simple and reliable QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method was modified, developed and validated for the determination of dichlorprop-P, bentazone and its metabolites (6-hydroxy-bentazone and 8-hydroxy-bentazone) in wheat (wheat plants, wheat straw and grains of wheat) using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The average recoveries of this method ranged from 72.9% to 108.7%, and the limits of quantification (LOQs) were 2.5-12 µg/kg. The dissipation and final residue of four compounds in three provinces (Shandong, Jiangsu and Heilongjiang) in China were studied. The trial results showed that the half-lives of dichlorprop-P and bentazone were 1.9-2.5 days and 0.5-2.4 days in wheat plants, respectively. The terminal residues in grains of wheat and wheat straw at harvest were all much below the maximum residue limit (MRL) of 0.2 mg/kg for dichlorprop-P and 0.1 mg/kg for bentazone established by the European Union (EU, Regulation No. 396/2005).
[Mh] Termos MeSH primário: Ácido 2,4-Diclorofenoxiacético/análogos & derivados
Benzotiadiazinas/análise
Ecossistema
Herbicidas/análise
Triticum
[Mh] Termos MeSH secundário: Ácido 2,4-Diclorofenoxiacético/análise
Ácido 2,4-Diclorofenoxiacético/química
Benzotiadiazinas/química
China
Cromatografia Líquida de Alta Pressão/métodos
Meia-Vida
Herbicidas/química
Poluentes do Solo/análise
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzothiadiazines); 0 (Herbicides); 0 (Soil Pollutants); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); J7YV2RKO6Q (dichlorprop); R4S7ZGZ9CT (bentazone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160531
[St] Status:MEDLINE


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[PMID]:27156769
[Au] Autor:Zhu S; Hao X; Zhang S; Qin X; Chen X; Zhu C
[Ad] Endereço:Department of Applied Chemistry, Beijing Institute of Technology, Zhongguancun South Street, 100081 Beijing, China.
[Ti] Título:Synthesis of benzothiadiazine derivatives exhibiting dual activity as aldose reductase inhibitors and antioxidant agents.
[So] Source:Bioorg Med Chem Lett;26(12):2880-2885, 2016 06 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Several multifunctional benzothiadiazine derivatives were synthesized and examined for their inhibition to the enzyme aldose reductase and in vitro antioxidant activity to identify novel drugs for diabetes and its complications. Most of them exhibited good inhibitory activity. Importantly, a number of compounds demonstrated strong antioxidant activity and one compound in particular was extremely active in the DPPH radical scavenging and MDA inhibition analysis. The DPPH radical scavenging rate with this compound was 98.0%, 92.3% and 42.1% at concentrations of 100µM, 10µM, and 1µM, respectively, and the initial reaction rate was faster than Trolox at a concentration of 10µM.
[Mh] Termos MeSH primário: Aldeído Redutase/antagonistas & inibidores
Antioxidantes/farmacologia
Benzotiadiazinas/farmacologia
Inibidores Enzimáticos/farmacologia
[Mh] Termos MeSH secundário: Aldeído Redutase/metabolismo
Antioxidantes/síntese química
Antioxidantes/química
Benzotiadiazinas/síntese química
Benzotiadiazinas/química
Relação Dose-Resposta a Droga
Inibidores Enzimáticos/síntese química
Inibidores Enzimáticos/química
Seres Humanos
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiadiazines); 0 (Enzyme Inhibitors); EC 1.1.1.21 (Aldehyde Reductase)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE



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