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[PMID]:23292636
[Au] Autor:Wang L; Ma C; Wipf P; Liu H; Su W; Xie XQ
[Ad] Endereço:Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, Pittsburgh, PA, USA.
[Ti] Título:TargetHunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database.
[So] Source:AAPS J;15(2):395-406, 2013 Apr.
[Is] ISSN:1550-7416
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Target identification of the known bioactive compounds and novel synthetic analogs is a very important research field in medicinal chemistry, biochemistry, and pharmacology. It is also a challenging and costly step towards chemical biology and phenotypic screening. In silico identification of potential biological targets for chemical compounds offers an alternative avenue for the exploration of ligand-target interactions and biochemical mechanisms, as well as for investigation of drug repurposing. Computational target fishing mines biologically annotated chemical databases and then maps compound structures into chemogenomical space in order to predict the biological targets. We summarize the recent advances and applications in computational target fishing, such as chemical similarity searching, data mining/machine learning, panel docking, and the bioactivity spectral analysis for target identification. We then described in detail a new web-based target prediction tool, TargetHunter (http://www.cbligand.org/TargetHunter). This web portal implements a novel in silico target prediction algorithm, the Targets Associated with its MOst SImilar Counterparts, by exploring the largest chemogenomical databases, ChEMBL. Prediction accuracy reached 91.1% from the top 3 guesses on a subset of high-potency compounds from the ChEMBL database, which outperformed a published algorithm, multiple-category models. TargetHunter also features an embedded geography tool, BioassayGeoMap, developed to allow the user easily to search for potential collaborators that can experimentally validate the predicted biological target(s) or off target(s). TargetHunter therefore provides a promising alternative to bridge the knowledge gap between biology and chemistry, and significantly boost the productivity of chemogenomics researchers for in silico drug design and discovery.
[Mh] Termos MeSH primário: Simulação por Computador
Mineração de Dados/métodos
Bases de Dados de Compostos Químicos
Descoberta de Drogas/métodos
Modelos Moleculares
Software
[Mh] Termos MeSH secundário: Algoritmos
Fármacos Anti-HIV/química
Fármacos Anti-HIV/farmacologia
Anti-Hipertensivos/química
Anti-Hipertensivos/farmacologia
Antineoplásicos/química
Antineoplásicos/farmacologia
Inteligência Artificial
Benzofuranos/química
Benzofuranos/farmacologia
Gráficos por Computador
Reposicionamento de Medicamentos
Simulação de Acoplamento Molecular
Estrutura Molecular
Antagonistas Muscarínicos/química
Antagonistas Muscarínicos/farmacologia
Politiazida/química
Politiazida/farmacologia
Pirrolidinas/química
Pirrolidinas/farmacologia
Reprodutibilidade dos Testes
Relação Estrutura-Atividade
Interface Usuário-Computador
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antihypertensive Agents); 0 (Antineoplastic Agents); 0 (Benzofurans); 0 (Muscarinic Antagonists); 0 (Pyrrolidines); 36780APV5N (Polythiazide); APG9819VLM (darifenacin)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130108
[St] Status:MEDLINE
[do] DOI:10.1208/s12248-012-9449-z


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[PMID]:12217863
[Au] Autor:Frindt G; McNair T; Dahlmann A; Jacobs-Palmer E; Palmer LG
[Ad] Endereço:Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, New York 10021, USA.
[Ti] Título:Epithelial Na channels and short-term renal response to salt deprivation.
[So] Source:Am J Physiol Renal Physiol;283(4):F717-26, 2002 Oct.
[Is] ISSN:1931-857X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To test the role of epithelial Na channels in the day-to-day regulation of renal Na excretion, rats were infused via osmotic minipumps with the Na channel blocker amiloride at rates that achieved drug concentrations of 2-5 microM in the lumen of the distal nephron. Daily Na excretion rates were unchanged, although amiloride-treated animals tended to excrete more Na in the afternoon and less in the late evening than controls. When the rats were given a low-Na diet, Na excretion rates were elevated in the amiloride-treated group within 4 h and remained higher than controls for at least 48 h. Adrenalectomized animals responded similarly to the low-Na diet. In contrast, rats infused with polythiazide at rates designed to inhibit NaCl transport in the distal tubule were able to conserve Na as well as did the controls. Injection of aldosterone (2 microg/100 g body wt) decreased Na excretion in control animals after a 1-h delay. This effect was largely abolished in amiloride-treated rats. On the basis of quantitative analysis of the results, we conclude that activation of amiloride-sensitive channels by mineralocorticoids accounts for 50-80% of the immediate natriuretic response of the kidney to a reduction in Na intake. Furthermore, the channels are necessary to achieve minimal rates of Na excretion during more chronic Na deprivation.
[Mh] Termos MeSH primário: Células Epiteliais/metabolismo
Rim/fisiologia
Canais de Sódio/fisiologia
Sódio/deficiência
[Mh] Termos MeSH secundário: Aldosterona/farmacologia
Amilorida/farmacologia
Animais
Cromatografia Líquida de Alta Pressão
Ritmo Circadiano/fisiologia
Dieta Hipossódica
Diuréticos/farmacologia
Eletrólitos/sangue
Células Epiteliais/efeitos dos fármacos
Feminino
Rim/efeitos dos fármacos
Túbulos Renais Coletores/citologia
Túbulos Renais Coletores/efeitos dos fármacos
Túbulos Renais Coletores/metabolismo
Cinética
Politiazida/farmacologia
Politiazida/urina
Ratos
Ratos Sprague-Dawley
Bloqueadores dos Canais de Sódio
Canais de Sódio/efeitos dos fármacos
Inibidores de Simportadores de Cloreto de Sódio/farmacologia
Inibidores de Simportadores de Cloreto de Sódio/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Diuretics); 0 (Electrolytes); 0 (Sodium Channel Blockers); 0 (Sodium Channels); 0 (Sodium Chloride Symporter Inhibitors); 36780APV5N (Polythiazide); 4964P6T9RB (Aldosterone); 7DZO8EB0Z3 (Amiloride); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:0210
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020910
[St] Status:MEDLINE


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[PMID]:15503623
[Au] Autor:Gregoric A; Bracic K; Marcun-Varda N
[Ad] Endereço:Department of Pediatrics, Maribor Teaching Hospital, Maribor, Slovenia. pediatrija.mb@sb-mb.si
[Ti] Título:Familial hypomagnesemia--hypercalciuria and pseudotumor cerebri.
[So] Source:Wien Klin Wochenschr;113 Suppl 3:59-61, 2001.
[Is] ISSN:0043-5325
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Approximately 30 patients with familial hypomagnesemia-hypercalciuria have been reported. We describe an 8-year-old girl with cardinal findings of familial hypomagnesemia-hypercalciuria (hypomagnesemia, hypermagnesiuria, hypercalciuria, renal insufficiency, hyperuricemia, elevated serum parathormone, hyposthenuria and nephrocalcinosis), who received combination therapy consisting of magnesium salts, thiazide diuretic and potassium supplementation. At the 4-year follow-up investigation under this treatment, the patient was found to have cerebral pseudotumor (increased intracranial pressure with normal or small ventricles on neuroimaging, no evidence of an intracranial mass and normal cerebrospinal fluid composition) with papilledema and visual field defects. Thiazide therapy was terminated and the cerebral pseudotumor disappeared. The authors hypothesize that cerebral pseudotumor in this patient was related to severe hypocalcemia, as a consequence of profound hypomagnesemia induced by protracted thiazide treatment. To our knowledge, this is the first report of a child with familial hypomagnesemia-hypercalciuria who developed pseudotumor cerebri after thiazide therapy.
[Mh] Termos MeSH primário: Cálcio/urina
Deficiência de Magnésio/genética
Nefrocalcinose/genética
Pseudotumor Cerebral/genética
[Mh] Termos MeSH secundário: Criança
Diuréticos
Quimioterapia Combinada
Feminino
Seguimentos
Seres Humanos
Hipocalcemia/induzido quimicamente
Hipocalcemia/diagnóstico
Compostos de Magnésio/efeitos adversos
Compostos de Magnésio/uso terapêutico
Deficiência de Magnésio/tratamento farmacológico
Nefrocalcinose/diagnóstico
Nefrocalcinose/tratamento farmacológico
Politiazida/efeitos adversos
Politiazida/uso terapêutico
Potássio/efeitos adversos
Potássio/uso terapêutico
Pseudotumor Cerebral/induzido quimicamente
Pseudotumor Cerebral/diagnóstico
Fatores de Risco
Inibidores de Simportadores de Cloreto de Sódio/efeitos adversos
Inibidores de Simportadores de Cloreto de Sódio/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 0 (Magnesium Compounds); 0 (Sodium Chloride Symporter Inhibitors); 36780APV5N (Polythiazide); RWP5GA015D (Potassium); SY7Q814VUP (Calcium)
[Em] Mês de entrada:0412
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041027
[St] Status:MEDLINE


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[PMID]:10894798
[Au] Autor:Monroy A; Plata C; Hebert SC; Gamba G
[Ad] Endereço:Molecular Physiology Unit, Instituto Nacional de la Nutrición Salvador Zubirán and Instituto de Investigaciones Biomédicas, National University of Mexico, Tlalpan 14000 Mexico City, Mexico.
[Ti] Título:Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.
[So] Source:Am J Physiol Renal Physiol;279(1):F161-9, 2000 Jul.
[Is] ISSN:1931-857X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC) is the major pathway for salt reabsorption in the apical membrane of the mammalian distal convoluted tubule. When expressed in Xenopus laevis oocytes, rat TSC exhibits high affinity for both cotransported ions, with the Michaelis-Menten constant (K(m)) for Na(+) of 7.6 +/- 1.6 mM and for Cl(-) of 6.3 +/- 1.1 mM, and Hill coefficients for Na(+) and Cl(-) consistent with electroneutrality. The affinities of both Na(+) and Cl(-) were increased by increasing concentration of the counterion. The IC(50) values for thiazides were affected by both extracellular Na(+) and Cl(-). The higher the Na(+) or Cl(-) concentration, the lower the inhibitory effect of thiazides. Finally, rTSC function is affected by extracellular osmolarity. We propose a transport model featuring a random order of binding in which the binding of each ion facilitates the binding of the counterion. Both ion binding sites alter thiazide-mediated inhibition of transport, indicating that the thiazide-binding site is either shared or modified by both Na(+) and Cl(-).
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Receptores de Droga/metabolismo
Inibidores de Simportadores de Cloreto de Sódio/metabolismo
Inibidores de Simportadores de Cloreto de Sódio/farmacologia
Sódio/metabolismo
Simportadores
[Mh] Termos MeSH secundário: Animais
Bendroflumetiazida/metabolismo
Bendroflumetiazida/farmacologia
Sítios de Ligação/efeitos dos fármacos
Transporte Biológico/efeitos dos fármacos
Proteínas de Transporte/genética
Cloretos/metabolismo
Cloretos/farmacologia
Diuréticos
Hidroclorotiazida/metabolismo
Hidroclorotiazida/farmacologia
Concentração de Íons de Hidrogênio
Concentração Inibidora 50
Cinética
Metolazona/metabolismo
Metolazona/farmacologia
Microinjeções
Modelos Biológicos
Oócitos/efeitos dos fármacos
Oócitos/metabolismo
Concentração Osmolar
Politiazida/metabolismo
Politiazida/farmacologia
Ratos
Receptores de Droga/genética
Sódio/farmacologia
Simportadores de Cloreto de Sódio
Membro 3 da Família 12 de Carreador de Soluto
Xenopus
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Carrier Proteins); 0 (Chlorides); 0 (Diuretics); 0 (Receptors, Drug); 0 (Slc12a3 protein, rat); 0 (Sodium Chloride Symporter Inhibitors); 0 (Sodium Chloride Symporters); 0 (Solute Carrier Family 12, Member 3); 0 (Symporters); 0 (thiazide receptor); 0J48LPH2TH (Hydrochlorothiazide); 36780APV5N (Polythiazide); 5Q52X6ICJI (Bendroflumethiazide); 9NEZ333N27 (Sodium); TZ7V40X7VX (Metolazone)
[Em] Mês de entrada:0008
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000715
[St] Status:MEDLINE


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[PMID]:9247782
[Au] Autor:Cakalaroski K; Ivanovski N; Grozdanovski R; Ristovska V; Polenakovic M
[Ad] Endereço:Medical Faculty, Department of Nephrology, University of Skopje, Macedonia.
[Ti] Título:Long-term diuretic therapy in patients with chronic renal failure.
[So] Source:Clin Nephrol;48(1):56-8, 1997 Jul.
[Is] ISSN:0301-0430
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Ten patients with chronic renal failure from different genesis (serum creatinine levels 150-200 mumol/l), were evaluated from the aspect of the effect of the diuretic therapy. The effects of furosemide (FUR) and polythiazide (POL) were assessed after 3-month application. The mean values of the estimated parameters before treatment, after 3-month administration of FUR as a monotherapy and after the next 3 months simultaneously used (FUR + POL), presented a stable increase of the diuresis, without statistically significant changes of the global renal function, and triglyceride disorders. On the contrary, the improvement of calciuria through combined using of furosemide and polythiazide is statistically and clinically significant.
[Mh] Termos MeSH primário: Diuréticos/uso terapêutico
Furosemida/uso terapêutico
Falência Renal Crônica/tratamento farmacológico
Politiazida/uso terapêutico
Inibidores de Simportadores de Cloreto de Sódio/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
Meia-Idade
Fatores de Tempo
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 0 (Sodium Chloride Symporter Inhibitors); 36780APV5N (Polythiazide); 7LXU5N7ZO5 (Furosemide)
[Em] Mês de entrada:9709
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970701
[St] Status:MEDLINE


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[PMID]:2490543
[Au] Autor:Agatonovic-Kustrin S; Zivanovic LJ
[Ad] Endereço:Institute of Pharmaceutical Chemistry, Faculty of Pharmacy, Belgrade, Yugoslavia.
[Ti] Título:Spectrophotometric study of polythiazide-palladium (II) complex.
[So] Source:J Pharm Biomed Anal;7(12):1559-64, 1989.
[Is] ISSN:0731-7085
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A quantitative spectrophotometric method using Pd(II) chloride as analytical reagent for the determination of polythiazide in pharmaceutical preparations is described in this study. It has been found that polythiazide reacts with Pd(II) chloride in the pH range 3.6-5.8, forming a red, water-soluble (1:1) complex with maximum absorbance at 527 nm. At the optimum pH of 4.8 and an ionic strength mu = 0.1 M, the conditional stability constant of the complex is found to be log K' = 4.77. The molar absorptivity at 527 nm is 3.2 x 10(3) l mol-1 cm-1. Good agreement with Beer's law was found for polythiazide concentrations up to 2.2 mmol l-1. The nominal percent recovery of polythiazide was 99.5% (n = 20). The simplicity, selectivity and sensitivity of the method described is suitable for rapid and accurate determinations of polythiazide in tablets.
[Mh] Termos MeSH primário: Paládio/análise
Politiazida/análise
[Mh] Termos MeSH secundário: Estabilidade de Medicamentos
Concentração de Íons de Hidrogênio
Indicadores e Reagentes
Espectrofotometria Ultravioleta
Comprimidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indicators and Reagents); 0 (Tablets); 36780APV5N (Polythiazide); 5TWQ1V240M (Palladium)
[Em] Mês de entrada:9108
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:890101
[St] Status:MEDLINE


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[PMID]:3654894
[Au] Autor:Schöneshöfer M; Heilmann P; Rejaibi R
[Ad] Endereço:Institute of Clinical Chemistry and Biochemistry, Klinikum Charlottenburg der Freien Universität, Berlin, F.R.G.
[Ti] Título:Automated column liquid chromatographic determination of polythiazide in human serum.
[So] Source:J Chromatogr;417(2):434-8, 1987 Jul 03.
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Mh] Termos MeSH primário: Politiazida/sangue
[Mh] Termos MeSH secundário: Autoanálise
Cromatografia Líquida de Alta Pressão
Estabilidade de Medicamentos
Seres Humanos
Solventes
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solvents); 36780APV5N (Polythiazide)
[Em] Mês de entrada:8711
[Cu] Atualização por classe:131213
[Lr] Data última revisão:
131213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:870703
[St] Status:MEDLINE


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[PMID]:3541602
[Au] Autor:Okun R; Kraut J
[Ti] Título:Prazosin versus captopril as initial therapy. Effect on hypertension and lipid levels.
[So] Source:Am J Med;82(1A):58-63, 1987 Jan 05.
[Is] ISSN:0002-9343
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A randomized, parallel group study evaluated the safety, efficacy, and effect of the alpha blocking agent prazosin and the angiotensin converting enzyme inhibitor captopril on serum lipid levels in patients with mild to moderate hypertension. Baseline evaluations were performed on 31 patients after a four-week placebo washout period. Patients were randomly assigned to receive either prazosin (n = 15) or captopril (n = 16). Daily doses were titrated as follows: for prazosin, 1 mg two times daily to maximum of 20 mg per day; for captopril, 25 mg three times daily to a maximum of 450 mg per day. If diastolic blood pressure was not adequately controlled (less than 85 mm Hg) after four weeks of monotherapy, 1 mg of polythiazide was added to the daily regimen. There were no statistically significant differences between the drug groups for the measured variables in either the parallel or crossover phase of the study. Five of 15 prazosin-treated patients and six of 16 captopril-treated patients required the addition of thiazide to achieve blood pressure control.
[Mh] Termos MeSH primário: Captopril/uso terapêutico
Hipertensão/tratamento farmacológico
Lipídeos/sangue
Prazosina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Captopril/efeitos adversos
Quimioterapia Combinada
Seres Humanos
Hipertensão/sangue
Meia-Idade
Politiazida/administração & dosagem
Postura
Prazosina/efeitos adversos
Distribuição Aleatória
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Lipids); 36780APV5N (Polythiazide); 9G64RSX1XD (Captopril); XM03YJ541D (Prazosin)
[Em] Mês de entrada:8702
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:870105
[St] Status:MEDLINE


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[PMID]:3544727
[Au] Autor:Solomon RJ; Stillman N; Weinberg MS
[Ti] Título:Thiazide induced hypotension: the role of plasma volume reduction and the urinary kallikrein system.
[So] Source:Adv Exp Med Biol;198 Pt B:243-51, 1986.
[Is] ISSN:0065-2598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The hypotensive response the thiazide diuretics was studied in 15 males with moderate essential hypertension and correlated with serial changes in plasma volume, weight, plasma renin activity, urinary aldosterone, and urinary kallikrein, both total and activity. A greater than 10 mmHg fall in mean arterial pressure after four weeks of treatment defined the responders to therapy (n = 10) while all others were considered non-responders (n = 5). In responders, the fall in mean arterial pressure was accompanied by sustained reduction in plasma volume and weight. No sustained fall in plasma volume was noted in non-responders. Plasma renin activity and urinary aldosterone excretion increased in responders but not in non-responders. Urinary kallikrein, both total and active, increased in the responders but remained unchanged in the non-responders. The results are consistent with the hypothesis that a sustained reduction in plasma volume is necessary for the maintenance of a hypotensive response to thiazides. Stimulation of the renal kallikrein-kinin system may be necessary to balance the antinatriuretic and pressor effects of the renin-angiotensin-aldosterone system. If unopposed, this system would return plasma volume and blood pressure to pretreatment levels.
[Mh] Termos MeSH primário: Hidroclorotiazida/uso terapêutico
Hipertensão/tratamento farmacológico
Hipotensão/fisiopatologia
Calicreínas/urina
Volume Plasmático/efeitos dos fármacos
Politiazida/uso terapêutico
[Mh] Termos MeSH secundário: Aldosterona/urina
Pressão Sanguínea/efeitos dos fármacos
Seres Humanos
Hipertensão/fisiopatologia
Hipotensão/induzido quimicamente
Masculino
Renina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0J48LPH2TH (Hydrochlorothiazide); 36780APV5N (Polythiazide); 4964P6T9RB (Aldosterone); EC 3.4.21.- (Kallikreins); EC 3.4.23.15 (Renin)
[Em] Mês de entrada:8703
[Cu] Atualização por classe:161109
[Lr] Data última revisão:
161109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860101
[St] Status:MEDLINE


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[PMID]:4025632
[Au] Autor:Okada F
[Ti] Título:Depression after treatment with thiazide diuretics for hypertension.
[So] Source:Am J Psychiatry;142(9):1101-2, 1985 Sep.
[Is] ISSN:0002-953X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The authors reports eight cases of depression induced by thiazide diuretics prescribed for hypertension and discusses possible mechanisms behind this action. The side effects of thiazide diuretics may be overlooked when they are used with other hypertensives known to cause depression.
[Mh] Termos MeSH primário: Transtorno Depressivo/induzido quimicamente
Hipertensão/tratamento farmacológico
Inibidores de Simportadores de Cloreto de Sódio/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Pressão Sanguínea/efeitos dos fármacos
Diuréticos
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Politiazida/efeitos adversos
Triclormetiazida/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diuretics); 0 (Sodium Chloride Symporter Inhibitors); 36780APV5N (Polythiazide); Q58C92TUN0 (Trichlormethiazide)
[Em] Mês de entrada:8509
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:850901
[St] Status:MEDLINE



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