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  1 / 13 MEDLINE  
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[PMID]:27092414
[Au] Autor:Wang BL; Shi YX; Zhang SJ; Ma Y; Wang HX; Zhang LY; Wei W; Liu XH; Li YH; Li ZM; Li BJ
[Ad] Endereço:State-Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center (Tianjin), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China.
[Ti] Título:Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties.
[So] Source:Eur J Med Chem;117:167-78, 2016 Jul 19.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A series of novel carboxamide compounds 19a-19j, 20a-20j and 22a-22d containing piperazine and arylsulfonyl moieties have been synthesized. The bioassay results showed that some compounds exhibited favorable herbicidal activities against dicotyledonous plants and many of them possessed excellent antifungal activities. Among 24 novel compounds, some showed superiority over the commercial fungicides Chlorothalonil, Dimethomorph, Thiophanate-methyl, Iprodione, and Zhongshengmycin at 500 mg/L concentration. Some compounds also exhibited high KARI inhibitory activity at 100 µg/mL concentration and could be used as new KARI lead inhibitors for further studies. Moreover, SAR of these new compounds were comprehensively investigated using different computational methods in which 3D-QSAR model obtained provided useful information for further structural optimization for the discovery of new fungicides. The results of this research will contribute to explore comprehensive biological activities of piperazine-containing compounds in different areas of chemistry.
[Mh] Termos MeSH primário: Amidas/síntese química
Antifúngicos/síntese química
Herbicidas/síntese química
Relação Quantitativa Estrutura-Atividade
[Mh] Termos MeSH secundário: Amidas/farmacologia
Antifúngicos/farmacologia
Ácidos Arilsulfônicos/química
Herbicidas/farmacologia
Piperazinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amides); 0 (Antifungal Agents); 0 (Arylsulfonic Acids); 0 (Herbicides); 0 (Piperazines); 1RTM4PAL0V (piperazine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160420
[St] Status:MEDLINE


  2 / 13 MEDLINE  
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[PMID]:19181519
[Au] Autor:Sun D; Wang Z; Cardozo M; Choi R; Degraffenreid M; Di Y; He X; Jaen JC; Labelle M; Liu J; Ma J; Miao S; Sudom A; Tang L; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
[Ti] Título:Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1).
[So] Source:Bioorg Med Chem Lett;19(5):1522-7, 2009 Mar 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The synthesis and SAR of a series of arylsulfonylpiperazine inhibitors of 11beta-HSD1 are described. Optimization rapidly led to potent, selective, and orally bioavailable inhibitors demonstrating efficacy in a cynomolgus monkey ex vivo enzyme inhibition model.
[Mh] Termos MeSH primário: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1/antagonistas & inibidores
Ácidos Arilsulfônicos/síntese química
Piperazinas/síntese química
[Mh] Termos MeSH secundário: 11-beta-Hidroxiesteroide Desidrogenase Tipo 1/metabolismo
Administração Oral
Animais
Ácidos Arilsulfônicos/classificação
Ácidos Arilsulfônicos/farmacologia
Disponibilidade Biológica
Linhagem Celular
Cristalografia por Raios X
Estabilidade Enzimática/efeitos dos fármacos
Estabilidade Enzimática/fisiologia
Seres Humanos
Macaca fascicularis
Camundongos
Piperazinas/classificação
Piperazinas/farmacologia
Ratos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonic Acids); 0 (Piperazines); EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 1)
[Em] Mês de entrada:0908
[Cu] Atualização por classe:090223
[Lr] Data última revisão:
090223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090203
[St] Status:MEDLINE
[do] DOI:10.1016/j.bmcl.2008.12.114


  3 / 13 MEDLINE  
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[PMID]:17178220
[Au] Autor:Huber VJ; Tsujita M; Yamazaki M; Sakimura K; Nakada T
[Ad] Endereço:Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1-757 Asahi Machi Dori, Niigata 951-8585, Japan. vjhuber@bri.niigata-u.ac.jp
[Ti] Título:Identification of arylsulfonamides as Aquaporin 4 inhibitors.
[So] Source:Bioorg Med Chem Lett;17(5):1270-3, 2007 Mar 01.
[Is] ISSN:0960-894X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 microM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 microM. Phloretin was inactive under the same conditions.
[Mh] Termos MeSH primário: Aquaporina 4/antagonistas & inibidores
Ácidos Arilsulfônicos/farmacologia
Sulfonamidas/farmacologia
[Mh] Termos MeSH secundário: Acetazolamida/farmacologia
Animais
Transporte Biológico/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Oócitos
Osmose
Floretina/farmacologia
Relação Estrutura-Atividade
Transfecção
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aquaporin 4); 0 (Arylsulfonic Acids); 0 (Sulfonamides); 059QF0KO0R (Water); O3FX965V0I (Acetazolamide); S5J5OE47MK (Phloretin)
[Em] Mês de entrada:0705
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061221
[St] Status:MEDLINE


  4 / 13 MEDLINE  
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[PMID]:16193746
[Au] Autor:Lara-Martín PA; Gómez-Parra A; González-Mazo E
[Ad] Endereço:Universidad de Cádiz, Facultad de Ciencias del Mar y Ambientales, Departamento de Química Física, Avenida República Saharaui s/n 11510 Puerto Real, Cádiz, Spain.
[Ti] Título:Determination and distribution of alkyl ethoxysulfates and linear alkylbenzene sulfonates in coastal marine sediments from the Bay of Cadiz (southwest of Spain).
[So] Source:Environ Toxicol Chem;24(9):2196-202, 2005 Sep.
[Is] ISSN:0730-7268
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The distribution of the two main anionic surfactants manufactured and used in the world, alkyl ethoxysulfates (AES) and linear alkylbenzene sulfonates (LAS), has been studied in sediments from a salt marsh and an estuary of the Bay of Cadiz (southwest of Spain). The identification and quantification of AES and LAS was carried out after automated Soxhlet extraction with methanol, followed by solid-phase extraction and liquid chromatography coupled to electrospray mass spectrometry. The latter procedure permitted the unequivocal identification of every LAS homologue as well as the AES homologues of up to 16 carbon atoms in their alkyl chain and of up to 12 ethylene oxide groups. Recoveries were in the range of 51% to 84% and limits of detection from 1 to 5 microg/kg. We have focused our attention particularly on AES because, in spite of their great use, these compounds have received less attention than LAS and their occurrence has not been described in marine environmental samples. Alkyl ethoxysulfates concentration values range between 100 and 400 microg/kg in the topmost layer of sediments at the sampling areas. The relative distribution of AES homologues shows higher percentages for the longer alkyl chain homologues in sediments as well as for the shorter ethoxymers. A decrease in LAS concentrations has been found relative to past studies in one of the sampling areas as a consequence of the reduction of urban wastewater discharges.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/química
Monitoramento Ambiental/métodos
Sedimentos Geológicos
Sulfatos/química
[Mh] Termos MeSH secundário: Ânions
Ácidos Arilsulfônicos/química
Cromatografia Líquida
Ecossistema
Poluição Ambiental
Óxido de Etileno/química
Espectrometria de Massas
Modelos Químicos
Água do Mar
Poluentes do Solo
Espanha
Tensoativos/química
Fatores de Tempo
Água
Poluentes da Água
Poluentes Químicos da Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Anions); 0 (Arylsulfonic Acids); 0 (Soil Pollutants); 0 (Sulfates); 0 (Surface-Active Agents); 0 (Water Pollutants); 0 (Water Pollutants, Chemical); 0 (alkylbenzyl sulfonic acid); 059QF0KO0R (Water); JJH7GNN18P (Ethylene Oxide)
[Em] Mês de entrada:0601
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051001
[St] Status:MEDLINE


  5 / 13 MEDLINE  
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[PMID]:11760056
[Au] Autor:León VM; Gómez-Parra A; González-Mazo E
[Ad] Endereço:Departamento de Química-Física, Facultad de Ciencias del Mar, Universidad de Cádiz, Puerto Real, Spain.
[Ti] Título:Determination of sulfophenylcarboxylic acids in marine samples by solid-phase extraction then high-performance liquid chromatography.
[So] Source:Fresenius J Anal Chem;371(4):479-85, 2001 Oct.
[Is] ISSN:0937-0633
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:An analytical method is presented for the determination of sulfophenylcarboxylic acids (SPC) produced by the biodegradation of linear alkylbenzene sulfonates (LAS) in marine samples. Isolation and concentration of the compounds was by solid-phase extraction. The different factors affecting extraction efficiency packing composition, pH, clean-up, ionic strength, and elution solvents--were studied and optimized. With the proposed method C4-C13SPC and C10-C13 LAS recoveries varied between 65% and 105%, with standard deviations between 0.1 and 5, respectively, for 100-mL samples and 100 microg L(-1) concentrations of each homolog. Detection limits within the range 0.5 g L(-1) (for C4SPC) to 1.0 g L(-1) (for C12SPC) were obtained by liquid chromatography with fluorescence detection. This method is the first to be proposed that enables the simultaneous determination of monocarboxylic SPC (C>3) and LAS homologs in marine samples by a simple, sensitive, and specific method giving high recoveries and reproducibility. SPC with from three to twelve carbon atoms in the carboxyl chain have been found in marine water samples.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/análise
Ácidos Arilsulfônicos/análise
Cromatografia Líquida de Alta Pressão/métodos
Água do Mar/análise
[Mh] Termos MeSH secundário: Ácidos Alcanossulfônicos/isolamento & purificação
Ácidos Arilsulfônicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Arylsulfonic Acids)
[Em] Mês de entrada:0201
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:020105
[St] Status:MEDLINE


  6 / 13 MEDLINE  
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[PMID]:11377170
[Au] Autor:Stephens CE; Felder TM; Sowell JW; Andrei G; Balzarini J; Snoeck R; De Clercq E
[Ad] Endereço:Division of Medicinal Chemistry, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA.
[Ti] Título:Synthesis and antiviral/antitumor evaluation of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes and related compounds as a new class of diarylsulfones.
[So] Source:Bioorg Med Chem;9(5):1123-32, 2001 May.
[Is] ISSN:0968-0896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Based on general SARs previously described for anti-HIV-1 diarylsulfone derivatives, a series of 2-amino- and 2-carboxamido-3-arylsulfonylthiophenes has been prepared and evaluated as potential antiviral and antitumor agents. In cell culture, some of the 2-aminothiophenes exhibited moderate and selective activity against HIV-1, with 2-amino-3-(2-nitrophenylsulfonyl)thiophene (7e) being most attractive (EC(50)=3.8 microg/mL, CC(50)=>100 microg/mL). In broad-spectrum antiviral assays, the 3-arylsulfonyl-2-(trifluoroacetamido)thiophenes (8c-g) and 2-acetamido-3-arylsulfonyl-5-nitrothiophenes (9f-g) proved considerably active (IC(50)=0.1-10 microg/mL) against human cytomegalovirus (CMV) and/or varicella zoster virus (VZV). Based on the activity of the trifluoroacetamides, ring-modified furan, N-(substituted)pyrrole, phenyl, and 3,4-thiophene analogues were prepared, and these compounds were also active against CMV and/or VZV, with the notable exception of the 3,4-thiophene derivative. In contrast to other amines, the 2-aminopyrrole precursors (13a-d) also exhibited potent activity against CMV. Unfortunately, most of these compounds displayed significant cytotoxicity against human fibroblasts, the cells supporting CMV and VZV replication, and thus selectivity indices were low. The most notable exception to this was the naphthyl-substituted aminopyrrole 13d, which exhibited both potent (IC(50)=0.3 microg/mL) and selective (CC(50)=>50 microg/mL) activity against CMV. Finally, thiophene aryl amides 8i-k displayed moderate in vitro activity against certain leukemia, breast, and colon cancer cell lines.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Antivirais/farmacologia
HIV-1/efeitos dos fármacos
Tiofenos/síntese química
Tiofenos/farmacologia
[Mh] Termos MeSH secundário: Fármacos Anti-HIV/síntese química
Fármacos Anti-HIV/farmacologia
Fármacos Anti-HIV/uso terapêutico
Antineoplásicos/síntese química
Antineoplásicos/uso terapêutico
Antivirais/síntese química
Ácidos Arilsulfônicos/síntese química
Neoplasias da Mama/tratamento farmacológico
Células Cultivadas
Neoplasias do Colo/tratamento farmacológico
Citomegalovirus/efeitos dos fármacos
HIV-2/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Leucemia/tratamento farmacológico
Simplexvirus/efeitos dos fármacos
Tiofenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-HIV Agents); 0 (Antineoplastic Agents); 0 (Antiviral Agents); 0 (Arylsulfonic Acids); 0 (Thiophenes)
[Em] Mês de entrada:0110
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010530
[St] Status:MEDLINE


  7 / 13 MEDLINE  
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[PMID]:10985552
[Au] Autor:León VM; González-Mazo E; Gómez-Parra A
[Ad] Endereço:Departamento de Química Física, Facultad de Ciencias del Mar, Universidad de Cádiz, Spain.
[Ti] Título:Handling of marine and estuarine samples for the determination of linear alkylbenzene sulfonates and sulfophenylcarboxylic acids.
[So] Source:J Chromatogr A;889(1-2):211-9, 2000 Aug 11.
[Is] ISSN:0021-9673
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Due to the physicochemical properties of linear alkylbenzene sulfonates (LAS), an anionic surfactant, it is difficult to obtain representative samples from sampling sites. Further, the high biodegradability of these compounds makes it necessary to study their biodegradation intermediates, sulfophenylcarboxylic acids (SPC) that do not have a surfactant character and show a different behavior. A procedure for determining and quantifying LAS and SPC in different environmental matrices by Soxhlet and solid-phase extractions and high-performance liquid chromatography is presented. The recoveries varied in the range from 85 to 102% for the water samples, and from 75 to 105% for sediment samples, with a standard deviation of between 1 and 7, and 2 and 11, respectively. Detection limits obtained were in the range from 5 to 10 microg kg(-1) for sediment samples (10 g) and from 0.2 to 0.4 microg l(-1) for water samples (250 ml). The method was applied to the simultaneous determination of LAS (C10-C13) and SPC (C4-C13) homologues in water, sediment and interstitial water collected from different areas of Spain.
[Mh] Termos MeSH primário: Ácidos Alcanossulfônicos/análise
Ácidos Arilsulfônicos/análise
Água do Mar/análise
[Mh] Termos MeSH secundário: Calibragem
Cromatografia Líquida de Alta Pressão/métodos
Sedimentos Geológicos/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkanesulfonic Acids); 0 (Arylsulfonic Acids); 0 (alkylbenzyl sulfonic acid)
[Em] Mês de entrada:0012
[Cu] Atualização por classe:090115
[Lr] Data última revisão:
090115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000914
[St] Status:MEDLINE


  8 / 13 MEDLINE  
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[PMID]:10417981
[Au] Autor:Passamonti S; Battiston L; Sottocasa GL
[Ad] Endereço:Dipartimento di Biochimica Biofisica e Chimica delle Macromolecole, Università degli Studi di Trieste, Italy. passamon@bbcm.univ.trieste.it
[Ti] Título:On the mechanism of bilitranslocase transport inactivation by phenylmethylsulphonyl fluoride.
[So] Source:Mol Membr Biol;16(2):167-72, 1999 Apr-Jun.
[Is] ISSN:0968-7688
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bilitranslocase is a plasma membrane carrier involved in the uptake of bilirubin and other organic anions from the blood into the liver cell. In the membrane, the carrier occurs as two interchangeable metastable forms, with high and low affinity for the substrates, respectively. The latter form can be specifically produced by either cysteine- or arginine modification. In liver plasma membrane vesicles, the serine-specific reagent phenylmethylsulphonyl fluoride is a partial inhibitor of bilitranslocase-mediated BSP transport rate. In this work, phenylmethyl-sulphonyl fluoride is shown to reduce the carrier maximal transport rate, without affecting its affinity for that substrate. In addition, it is found that the chemical modification caused by this reagent neither influences the equilibrium between the high- and the low-affinity forms nor prevents their free interconversion. From the effects of combined derivatizations of cysteine(s), arginine(s) and serine(s), it is concluded that the functionally relevant aminoacid residues lie in a close spatial arrangement. Also, in this study, the PMSF-modified serine(s) is shown to be involved in bilirubin binding by bilitranslocase.
[Mh] Termos MeSH primário: Transporte Biológico Ativo
Inibidores Enzimáticos/farmacologia
Proteínas de Membrana/antagonistas & inibidores
Fluoreto de Fenilmetilsulfonil/farmacologia
[Mh] Termos MeSH secundário: Animais
Ácidos Arilsulfônicos/metabolismo
Membrana Celular/efeitos dos fármacos
Cobre
Íons
Cinética
Fluoreto de Fenilmetilsulfonil/metabolismo
Ratos
Sulfobromoftaleína/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arylsulfonic Acids); 0 (Enzyme Inhibitors); 0 (Ions); 0 (Membrane Proteins); 0C2P5QKL36 (Sulfobromophthalein); 57KD15003I (Phenylmethylsulfonyl Fluoride); 71211-72-8 (bilitranslocase); 789U1901C5 (Copper)
[Em] Mês de entrada:9910
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990727
[St] Status:MEDLINE


  9 / 13 MEDLINE  
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[PMID]:9681137
[Au] Autor:Müller CE; Sandoval-Ramírez J; Schobert U; Geis U; Frobenius W; Klotz KN
[Ad] Endereço:Institut für Pharmazie und Lebensmittelchemie, Julius-Maximilians-Universität Würzburg, Pharmazeutische Chemie, Germany. mueller@pharmazie.uni-wuerzburg.de
[Ti] Título:8-(Sulfostyryl)xanthines: water-soluble A2A-selective adenosine receptor antagonists.
[So] Source:Bioorg Med Chem;6(6):707-19, 1998 Jun.
[Is] ISSN:0968-0896
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:8-(Sulfostyryl)xanthine derivatives were synthesized as water-soluble A2A-selective adenosine receptor (AR) antagonists. meta- and para-sulfostyryl-DMPX (3,7-dimethyl-1-propargylxanthine) derivatives 11a and 11b exhibited high affinity to rat A2A-AR in submicromolar concentrations, and were 20- to 30-fold selective versus rat A1-AR. Styryl-DMPX derivatives were inactive at human A2B- and A3-AR. 1,3-Dipropyl-8-p-sulfostyrylxanthine (13) or only a 7-methyl derivative (14) showed similar (13) or higher (14) A2A affinity than 11a and 11b but showed no (13) or only a low degree (14) of selectivity versus A1-, A2B-, and A3-AR. The A2A-selective sulfostyryl-DMPX derivatives exhibit high water-solubility and may be useful research tools for in vivo studies.
[Mh] Termos MeSH primário: Ácidos Arilsulfônicos/síntese química
Estimulantes do Sistema Nervoso Central/síntese química
Antagonistas de Receptores Purinérgicos P1
Estirenos/síntese química
Xantinas/síntese química
[Mh] Termos MeSH secundário: Animais
Ácidos Arilsulfônicos/química
Ácidos Arilsulfônicos/metabolismo
Ácidos Arilsulfônicos/farmacologia
Células CHO
Estimulantes do Sistema Nervoso Central/química
Estimulantes do Sistema Nervoso Central/metabolismo
Estimulantes do Sistema Nervoso Central/farmacologia
Córtex Cerebral/metabolismo
Cricetinae
Seres Humanos
Concentração de Íons de Hidrogênio
Espectroscopia de Ressonância Magnética
Ensaio Radioligante
Ratos
Receptor A2A de Adenosina
Receptores Purinérgicos P1/biossíntese
Proteínas Recombinantes/antagonistas & inibidores
Proteínas Recombinantes/biossíntese
Solubilidade
Relação Estrutura-Atividade
Estirenos/química
Estirenos/metabolismo
Estirenos/farmacologia
Xantinas/química
Xantinas/metabolismo
Xantinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonic Acids); 0 (Central Nervous System Stimulants); 0 (Purinergic P1 Receptor Antagonists); 0 (Receptor, Adenosine A2A); 0 (Receptors, Purinergic P1); 0 (Recombinant Proteins); 0 (Styrenes); 0 (Xanthines)
[Em] Mês de entrada:9809
[Cu] Atualização por classe:101118
[Lr] Data última revisão:
101118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980729
[St] Status:MEDLINE


  10 / 13 MEDLINE  
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PubMed Central Texto completo
[PMID]:7479060
[Au] Autor:Efimov VA; Kalinkina AL; Chakhmakhcheva OG; Hill TS; Jayaraman K
[Ad] Endereço:Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
[Ti] Título:New efficient sulfurizing reagents for the preparation of oligodeoxyribonucleotide phosphorothioate analogues.
[So] Source:Nucleic Acids Res;23(20):4029-33, 1995 Oct 25.
[Is] ISSN:0305-1048
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A set of new sulfurizing agents representing disulfides of arylsulfonic acids has been developed for the automated synthesis of phosphorothioate oligonucleotide analogues via the phosphoramidite method. These reagents, such as bis(benzenesulfonyl)disulfide, bis(p-toluenesulfonyl)disulfide, bis(p-methoxybenzensulfonyl)disulfide, and bis (p-chlorobenzenesulfonyl) disulfide, are easily prepared crystalline solid compounds. They are relatively inexpensive, easy to handle, and efficiently convert internucleotide cyanoethyl phosphite to the phosphorothioate triester within 1-2 min. The efficiency of phosphorothioate oligonucleotide synthesis with the use of these reagents is comparable to that of phosphodiester oligonucleotides.
[Mh] Termos MeSH primário: Ácidos Arilsulfônicos
Dissulfetos
Oligodesoxirribonucleotídeos/síntese química
Tionucleotídeos/síntese química
[Mh] Termos MeSH secundário: Sequência de Bases
Dissulfetos/síntese química
Indicadores e Reagentes
Dados de Sequência Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonic Acids); 0 (Disulfides); 0 (Indicators and Reagents); 0 (Oligodeoxyribonucleotides); 0 (Thionucleotides)
[Em] Mês de entrada:9512
[Cu] Atualização por classe:130922
[Lr] Data última revisão:
130922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:951025
[St] Status:MEDLINE



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