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[PMID]:28374113
[Au] Autor:Mehdizadeh M; Alebrahim MT; Roushani M
[Ad] Endereço:Department of Agronomy and Plant Breeding, Faculty of Agriculture and Natural Resources, University of Mohaghegh Ardabili, Ardabil, Iran.
[Ti] Título:Determination of Two Sulfonylurea Herbicides Residues in Soil Environment Using HPLC and Phytotoxicity of These Herbicides by Lentil Bioassay.
[So] Source:Bull Environ Contam Toxicol;99(1):93-99, 2017 Jul.
[Is] ISSN:1432-0800
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A HPLC-UV detection system was used for determination of sulfosulfuron and tribenuron methyl residues from soils. The soils were fortified with sulfosulfuron and tribenuron methyl at rates of 26 and 15 g a.i. ha respectively and samples were taken randomly on 0 (2 h), 1, 2, 4, 10, 20, 40, 60, 90 and 120 days after treatment. The final extracts were prepared for analysis by HPLC. The results showed that degradation of both herbicides in the silty loam soil was faster than sandy loam soil. Half-life of sulfosulfuron was ranged from 5.37 to 10.82 days however this value for tribenuron methyl was ranged from 3.23 to 5.72 days on different soils. The residue of both herbicides at 120 days after application in wheat field had no toxicitic effect on lentil. It was concluded that HPLC analysis procedure was an appropriate method for determination of these herbicides from soils.
[Mh] Termos MeSH primário: Herbicidas/análise
Lens (Planta)/química
Poluentes do Solo/análise
Compostos de Sulfonilureia/análise
[Mh] Termos MeSH secundário: Sulfonatos de Arila
Bioensaio
Cromatografia Líquida de Alta Pressão/métodos
Meia-Vida
Herbicidas/toxicidade
Lens (Planta)/efeitos dos fármacos
Pirimidinas
Solo/química
Poluentes do Solo/toxicidade
Sulfonamidas
Compostos de Sulfonilureia/toxicidade
Triticum/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Herbicides); 0 (Pyrimidines); 0 (Soil); 0 (Soil Pollutants); 0 (Sulfonamides); 0 (Sulfonylurea Compounds); 2589ET7417 (metsulfuron methyl); Y0XC20DL6D (sulfosulfuron)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1007/s00128-017-2076-8


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[PMID]:28139897
[Au] Autor:Gesheff T; Barbour C
[Ad] Endereço:Kaufman Cancer Center, University of Maryland, Bel Air, Maryland.
[Ti] Título:Oral antiplatelet agents for the management of acute coronary syndromes: A review for nurses and allied healthcare professionals.
[So] Source:J Am Assoc Nurse Pract;29(2):104-115, 2017 Feb.
[Is] ISSN:2327-6924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: We review the use of oral antiplatelet (OAP) therapies in acute coronary syndrome (ACS) management for nurse practitioners (NPs), focusing on current guideline recommendations. DATA SOURCES: Treatment guidelines and clinical articles from PubMed. CONCLUSIONS: Guidelines recommend that dual antiplatelet therapy with a P2Y inhibitor and aspirin be initiated for ACS management. The P2Y inhibitor clopidogrel has established efficacy, but is associated with suboptimal and delayed platelet inhibition and variability in response. The newer P2Y inhibitors prasugrel and ticagrelor have demonstrated superior efficacy outcomes versus clopidogrel. Consequently, non-ST-segment elevation ACS (NSTE-ACS) guidelines now recommend that ticagrelor be used in preference to clopidogrel for patients treated with stents or managed medically. Because of their higher potency, prasugrel and ticagrelor are associated with increased bleeding rates versus clopidogrel, but with no increased risk of severe or life-threatening bleeding. Guidelines recommend dual antiplatelet therapy be continued ≥12 months in both medically managed and stented ACS patients, and in some cases beyond this, in absence of high bleeding risk. Updated guidelines assign preference to ticagrelor over clopidogrel for maintenance therapy in patients with NSTE-ACS and ST-elevation myocardial infarction. IMPLICATIONS FOR PRACTICE: Enhanced NP understanding of OAP agents and current guidelines could contribute to improved ACS patient management.
[Mh] Termos MeSH primário: Síndrome Coronariana Aguda/tratamento farmacológico
Administração Oral
Gerenciamento Clínico
Inibidores da Agregação de Plaquetas/uso terapêutico
[Mh] Termos MeSH secundário: Adenosina/efeitos adversos
Adenosina/análogos & derivados
Adenosina/uso terapêutico
Sulfonatos de Arila/efeitos adversos
Sulfonatos de Arila/uso terapêutico
Aspirina/efeitos adversos
Aspirina/uso terapêutico
Seres Humanos
Profissionais de Enfermagem
Inibidores da Agregação de Plaquetas/efeitos adversos
Cloridrato de Prasugrel/efeitos adversos
Cloridrato de Prasugrel/uso terapêutico
Ticlopidina/efeitos adversos
Ticlopidina/análogos & derivados
Ticlopidina/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Platelet Aggregation Inhibitors); 2589ET7417 (metsulfuron methyl); A74586SNO7 (clopidogrel); G89JQ59I13 (Prasugrel Hydrochloride); GLH0314RVC (Ticagrelor); K72T3FS567 (Adenosine); OM90ZUW7M1 (Ticlopidine); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.1002/2327-6924.12438


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[PMID]:27215490
[Au] Autor:Sweerus K; Lachowicz-Scroggins M; Gordon E; LaFemina M; Huang X; Parikh M; Kanegai C; Fahy JV; Frank JA
[Ad] Endereço:Division of Pulmonary, Critical Care, Sleep and Allergy Medicine, University of California, San Francisco, Calif; San Francisco VA Medical Center and Northern California Institute for Research and Education, San Francisco, Calif.
[Ti] Título:Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.
[So] Source:J Allergy Clin Immunol;139(1):72-81.e1, 2017 Jan.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Epithelial barrier dysfunction and increased permeability may contribute to antigen sensitization and disease progression in asthma. Claudin-18.1 is the only known lung-specific tight junction protein, but its contribution to airway barrier function or asthma is unclear. OBJECTIVES: We sought to test the hypotheses that claudin-18 is a determinant of airway epithelial barrier function that is downregulated by IL-13 and that claudin-18 deficiency results in increased aeroantigen sensitization and airway hyperresponsiveness. METHODS: Claudin-18.1 mRNA levels were measured in airway epithelial brushings from healthy controls and patients with asthma. In patients with asthma, claudin-18 levels were compared with a three-gene-mean marker of T 2 inflammation. Airway epithelial permeability changes due to claudin-18 deficiency were measured in 16HBE cells and claudin-18 null mice. The effect of IL-13 on claudin expression was determined in primary human airway epithelial cells and in mice. Airway hyperresponsiveness and serum IgE levels were compared in claudin-18 null and wild-type mice following aspergillus sensitization. RESULTS: Epithelial brushings from patients with asthma (n = 67) had significantly lower claudin-18 mRNA levels than did those from healthy controls (n = 42). Claudin-18 levels were lowest among T 2-high patients with asthma. Loss of claudin-18 was sufficient to impair epithelial barrier function in 16HBE cells and in mouse airways. IL-13 decreased claudin-18 expression in primary human cells and in mice. Claudin-18 null mice had significantly higher serum IgE levels and increased airway responsiveness following intranasal aspergillus sensitization. CONCLUSIONS: These data support the hypothesis that claudin-18 is an essential contributor to the airway epithelial barrier to aeroantigens. Furthermore, T 2 inflammation suppresses claudin-18 expression, potentially promoting sensitization and airway hyperresponsiveness.
[Mh] Termos MeSH primário: Asma/metabolismo
Claudinas/metabolismo
Mucosa Respiratória/metabolismo
Sistema Respiratório/metabolismo
[Mh] Termos MeSH secundário: Adulto
Animais
Antígenos de Fungos/imunologia
Sulfonatos de Arila/metabolismo
Aspergillus/imunologia
Asma/sangue
Asma/patologia
Asma/fisiopatologia
Linhagem Celular
Células Cultivadas
Claudinas/deficiência
Claudinas/genética
Seres Humanos
Imunoglobulina E/sangue
Interleucina-13/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Permeabilidade
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/genética
Sistema Respiratório/citologia
Sistema Respiratório/patologia
Sistema Respiratório/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Fungal); 0 (Arylsulfonates); 0 (CLDN18 protein, human); 0 (Claudins); 0 (Cldn18 protein, mouse); 0 (Interleukin-13); 0 (RNA, Messenger); 0 (RNA, Small Interfering); 37341-29-0 (Immunoglobulin E); I2W85YOX9L (pyranine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE


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[PMID]:27702486
[Au] Autor:Wang C; Ouyang X; Su S; Liang X; Zhang C; Wang W; Yuan Q; Li Q
[Ad] Endereço:College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China. Electronic address: chaow1990@yahoo.com.
[Ti] Título:Effect of sulfonated lignin on enzymatic activity of the ligninolytic enzymes Cα-dehydrogenase LigD and ß-etherase LigF.
[So] Source:Enzyme Microb Technol;93-94:59-69, 2016 Nov.
[Is] ISSN:1879-0909
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NAD -dependent Cα-dehydrogenase LigD and glutathione-dependent ß-etherase LigF which selectively cleave the ß-O-4 aryl ether linkage present in lignin, are key-enzymes for the biocatalytic depolymerization of lignin. However, the catalytic efficiency of the two enzymes is low when they are used to break down the ß-aryl ether linkage in natural lignin. When sulfonated lignin was added to LigF hydrolysis reactions, the conversion rate of MPHPV decreased significantly from 99.5% to 32.6%. On the contrary, sulfonated lignin has little affection on LigD, which the conversion rate of GGE only decreased from 41.7% to 41%. The strong nonspecific interactions of enzymes onto sulfonated lignin detected by surface plasmon resonance (SPR) and isothermal titration calorimetric (ITC) was obvious and universal, which can reduce enzyme activity of many enzymes, including ligninolytic enzyme ß-etherase LigF. To elucidate the exact mechanisms by which ß-etherase LigF interact with lignin, molecular modeling was applied. Finally, analysis on catalytic efficiency of LigD and LigF in different concentrations and molecular weights of sulfonated lignin, solution ionic strength, pH, temperature and concentration of Tween 80 revealed that electrostatic interactions and hydrophobic interactions play important roles in absorption between LigF and sulfonated lignin.
[Mh] Termos MeSH primário: Oxirredutases do Álcool/metabolismo
Proteínas de Bactérias/metabolismo
Lignina/metabolismo
Oxirredutases/metabolismo
[Mh] Termos MeSH secundário: Oxirredutases do Álcool/química
Sulfonatos de Arila/química
Sulfonatos de Arila/metabolismo
Proteínas de Bactérias/química
Biocatálise
Interações Hidrofóbicas e Hidrofílicas
Lignina/química
Modelos Moleculares
Simulação de Dinâmica Molecular
Peso Molecular
Oxirredutases/química
Peroxidases/química
Peroxidases/metabolismo
Sphingomonadaceae/enzimologia
Eletricidade Estática
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Bacterial Proteins); 9005-53-2 (Lignin); EC 1.- (Oxidoreductases); EC 1.- (aryl ether cleaving enzyme); EC 1.1.- (Alcohol Oxidoreductases); EC 1.1.1.- (Calpha-dehydrogenase); EC 1.11.1.- (Peroxidases); EC 1.11.1.- (lignin peroxidase)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


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[PMID]:27537868
[Au] Autor:Vera G; Lagos CF; Almendras S; Hebel D; Flores F; Valle-Corvalán G; Pessoa-Mahana CD; Mella-Raipán J; Montecinos R; Recabarren-Gajardo G
[Ad] Endereço:Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Avda. Vicuña Mackenna 4860, Macul 7820436, Santiago, Chile. glvera@uc.cl.
[Ti] Título:Extended N-Arylsulfonylindoles as 5-HT6 Receptor Antagonists: Design, Synthesis & Biological Evaluation.
[So] Source:Molecules;21(8), 2016 Aug 16.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Based on a known pharmacophore model for 5-HT6 receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT6 receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed antagonist profile in 5-HT6 receptor functional assays. Compounds 2-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(1-tosyl-1H-indol-3-yl)ethanol (4b), 1-(1-(4-iodophenylsulfonyl)-1H-indol-3-yl)-2-(4-(2-methoxyphenyl)piperazin-1-yl)ethanol (4g) and 2-(4-(2-methoxyphenyl)piperazin-1-yl)-1-(1-(naphthalen-1-ylsulfonyl)-1H-indol-3-yl)ethanol (4j) showed the best binding affinity (4b pKi = 7.87; 4g pKi = 7.73; 4j pKi = 7.83). Additionally, compound 4j was identified as a highly potent antagonist (IC50 = 32 nM) in calcium mobilisation functional assay.
[Mh] Termos MeSH primário: Sulfonatos de Arila/química
Indóis/síntese química
Receptores de Serotonina/metabolismo
Antagonistas da Serotonina/síntese química
[Mh] Termos MeSH secundário: Sítios de Ligação
Seres Humanos
Indóis/química
Indóis/farmacologia
Modelos Moleculares
Estrutura Molecular
Ligação Proteica
Receptores de Serotonina/química
Antagonistas da Serotonina/química
Antagonistas da Serotonina/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Indoles); 0 (Receptors, Serotonin); 0 (Serotonin Antagonists); 0 (serotonin 6 receptor)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE


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[PMID]:27495977
[Au] Autor:Yang Q; Deng W; Li X; Yu Q; Bai L; Zheng M
[Ad] Endereço:Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, 100193, China.
[Ti] Título:Target-site and non-target-site based resistance to the herbicide tribenuron-methyl in flixweed (Descurainia sophia L.).
[So] Source:BMC Genomics;17:551, 2016 08 05.
[Is] ISSN:1471-2164
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Flixweed (Descurainia sophia L.) is a troublesome and widespread broadleaf weed in winter fields in China, and has evolved high level resistance to acetolactate synthase (ALS)-inhibiting sulfonylurea herbicide tribenuron-methyl. RESULTS: We identified a resistant flixweed population (N11) exhibiting 116.3-fold resistance to tribenuron-methyl relative to the susceptible population (SD8). Target-site ALS gene mutation Pro-197-Thr was identified in resistant plants. Moreover, the resistance can be reversed to 28.7-fold by the cytochrome P450 inhibitor malathion. The RNA-Sequencing was employed to identify candidate genes involved in non-target-site metabolic resistance in this population. Total 26 differentially expressed contigs were identified and eight of them (four P450s, one ABC transporter, three glycosyltransferase) verified by qRT-PCR. Consistent over-expression of the two contigs homology to CYP96A13 and ABCC1 transporter, respectively, were further qRT-PCR validated using additional plants from the resistant and susceptible populations. CONCLUSIONS: Tribenuron-methyl resistance in flixweed is controlled by target-site ALS mutation and non-target-site based mechanisms. Two genes, CYP96A13 and ABCC1 transporter, could play an important role in metabolic resistance to tribenuron-methyl in the resistant flixweed population and justify further functional studies.
[Mh] Termos MeSH primário: Sulfonatos de Arila/farmacologia
Brassicaceae/efeitos dos fármacos
Brassicaceae/genética
Resistência a Herbicidas/genética
Herbicidas/farmacologia
[Mh] Termos MeSH secundário: Acetolactato Sintase/genética
Adaptação Biológica/genética
Inibidores da Colinesterase/farmacologia
Biologia Computacional/métodos
Relação Dose-Resposta a Droga
Ativação Enzimática
Evolução Molecular
Perfilação da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Malation/farmacologia
Anotação de Sequência Molecular
Reprodutibilidade dos Testes
Análise de Sequência de DNA
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Cholinesterase Inhibitors); 0 (Herbicides); 2589ET7417 (metsulfuron methyl); EC 2.2.1.6 (Acetolactate Synthase); U5N7SU872W (Malathion)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171118
[Lr] Data última revisão:
171118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160807
[St] Status:MEDLINE
[do] DOI:10.1186/s12864-016-2915-8


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[PMID]:27048875
[Au] Autor:Hu X; Yu C; D Okochi K; Jin Y; Liu Z; Zhang W
[Ad] Endereço:Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun 130022, P. R. China. liu_zhenning@jlu.edu.cn.
[Ti] Título:Phenylene vinylene macrocycles as artificial transmembrane transporters.
[So] Source:Chem Commun (Camb);52(34):5848-51, 2016 Apr 30.
[Is] ISSN:1364-548X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of rigid phenylene vinylene macrocycles and phenylene ethynylene macrocycles with various substituents have been investigated as transmembrane ion channels. The length and polarity of the substituents have a significant effect on the ion channel formation and the mass transport efficiency. Macrocycles with strong aggregation facilitate ion passage across lipid bilayers.
[Mh] Termos MeSH primário: Alquinos/química
Ionóforos/química
Compostos Macrocíclicos/química
Estilbenos/química
[Mh] Termos MeSH secundário: Sulfonatos de Arila/química
Difusão Facilitada
Fluoresceínas/química
Corantes Fluorescentes/química
Concentração de Íons de Hidrogênio
Estrutura Molecular
Cloreto de Sódio/química
Lipossomas Unilamelares/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Alkynes); 0 (Arylsulfonates); 0 (Fluoresceins); 0 (Fluorescent Dyes); 0 (Ionophores); 0 (Macrocyclic Compounds); 0 (Stilbenes); 0 (Unilamellar Liposomes); 451W47IQ8X (Sodium Chloride); I2W85YOX9L (pyranine); V0YM2B16TS (fluorexon)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160407
[St] Status:MEDLINE
[do] DOI:10.1039/c6cc01657j


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[PMID]:26923841
[Au] Autor:Kathiravan A; Asha Jhonsi M
[Ad] Endereço:National Centre for Ultrafast Processes, University of Madras, Taramani Campus, Chennai, -600 113, Tamil Nadu, India. akathir23@hotmail.com.
[Ti] Título:Photoinduced electron transfer reactions of pyranine with benzoquinone and titanium dioxide.
[So] Source:Luminescence;31(7):1344-1348, 2016 Nov.
[Is] ISSN:1522-7243
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The fluorescence quenching of pyranine by benzoquinone in acetonitrile medium was studied using steady-state and time-resolved fluorescence techniques. The quenching process was characterized by a Stern-Volmer plot, which displayed a linear aspect. From the linear plot, the bimolecular quenching rate constant was obtained. The obtained rate constants are within diffused controlled limits. The results show that benzoquinone can efficiently quench the fluorescence of pyranine with dynamic quenching rate constants in the order of 10 M s , suggesting that the pyranine can act as a good electron donor for photoinduced electron transfer in artificial photosynthesis and organic solar cells. In addition, the electron injection dynamics of a pyranine/titanium dioxide semiconductor film was also investigated and electron injection from the excited state pyranine into the conduction band of titanium dioxide is suggested. These preliminary results hold promise for the possibility of using pyranine in dye-sensitized solar cells. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Sulfonatos de Arila/química
Benzoquinonas/química
Elétrons
Luz
Titânio/química
[Mh] Termos MeSH secundário: Acetonitrilos/química
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Arylsulfonates); 0 (Benzoquinones); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); I2W85YOX9L (pyranine); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160301
[St] Status:MEDLINE
[do] DOI:10.1002/bio.3113


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[PMID]:26874672
[Au] Autor:Mizuguchi H; Orimoto N; Kadota T; Kominami T; Das AK; Sawada A; Tamada M; Miyagi K; Adachi T; Matsumoto M; Kosaka T; Kitamura Y; Takeda N; Fukui H
[Ad] Endereço:Department of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Sho-machi, Tokushima 770-8505, Japan. Electronic address: guchi003@tokushima-u.ac.jp.
[Ti] Título:Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats.
[So] Source:J Pharmacol Sci;130(3):151-8, 2016 Mar.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Histamine H1 receptor (H1R) gene is upregulated in patients with pollinosis; its expression level is highly correlated with the nasal symptom severity. Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as inverse agonists. However, long-term treatment with antihistamines does not completely resolve toluene-2,4-diisocyanate (TDI)-induced nasal symptoms, although it can decrease H1R gene expression to the basal level, suggesting additional signaling is responsible for the pathogenesis of the allergic symptoms. Here, we show that treatment with suplatast tosilate in combination with antihistamines markedly alleviates nasal symptoms in TDI-sensitized rats. Suplatast suppressed TDI-induced upregulation of IL-9 gene expression. Suplatast also suppressed ionomycin/phorbol-12-myristate-13-acetate-induced upregulation of IL-2 gene expression in Jurkat cells, in which calcineurin (CN)/nuclear factor of activated T-cells (NFAT) signaling is known to be involved. Immunoblot analysis demonstrated that suplatast inhibited binding of NFAT to DNA. Furthermore, suplatast suppressed ionomycin-induced IL-9 mRNA upregulation in RBL-2H3 cells, in which CN/NFAT signaling is also involved. These data suggest that suplatast suppressed NFAT-mediated IL-9 gene expression in TDI-sensitized rats and this might be the underlying mechanism of the therapeutic effects of combined therapy of suplatast with antihistamine.
[Mh] Termos MeSH primário: Antialérgicos/farmacologia
Sulfonatos de Arila/farmacologia
Antagonistas dos Receptores Histamínicos/farmacologia
Hipersensibilidade/tratamento farmacológico
Interleucina-9/genética
Fatores de Transcrição NFATC/genética
Doenças Nasais/tratamento farmacológico
Compostos de Sulfônio/farmacologia
Tolueno 2,4-Di-Isocianato/toxicidade
[Mh] Termos MeSH secundário: Animais
Antialérgicos/uso terapêutico
Sulfonatos de Arila/uso terapêutico
Calcineurina/fisiologia
Células Cultivadas
Quimioterapia Combinada
Expressão Gênica/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos/uso terapêutico
Hipersensibilidade/genética
Interleucina-9/metabolismo
Masculino
Fatores de Transcrição NFATC/fisiologia
Doenças Nasais/genética
Ratos
Receptores Histamínicos H1/genética
Receptores Histamínicos H1/metabolismo
Transdução de Sinais/efeitos dos fármacos
Compostos de Sulfônio/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Allergic Agents); 0 (Arylsulfonates); 0 (Histamine Antagonists); 0 (Interleukin-9); 0 (NFATC Transcription Factors); 0 (Receptors, Histamine H1); 0 (Sulfonium Compounds); 17X7AFZ1GH (Toluene 2,4-Diisocyanate); C9J89787U1 (suplatast tosilate); EC 3.1.3.16 (Calcineurin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160215
[St] Status:MEDLINE


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[PMID]:26841835
[Au] Autor:Fujimoto N; Hamaguchi Y; Tanaka T
[Ad] Endereço:Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520-2192, Japan.
[Ti] Título:Vitiligo-like depigmentation with perifollicular pigment retention in systemic sclerosis treated successfully with suplatast tosilate.
[So] Source:Eur J Dermatol;26(1):110-2, 2016 Jan-Feb.
[Is] ISSN:1952-4013
[Cp] País de publicação:France
[La] Idioma:eng
[Mh] Termos MeSH primário: Sulfonatos de Arila/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Escleroderma Sistêmico/complicações
Compostos de Sulfônio/uso terapêutico
Vitiligo/complicações
Vitiligo/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Feminino
Folículo Piloso/patologia
Seres Humanos
Vitiligo/patologia
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Arylsulfonates); 0 (Dermatologic Agents); 0 (Sulfonium Compounds); C9J89787U1 (suplatast tosilate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE
[do] DOI:10.1684/ejd.2015.2687



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