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[PMID]:28783044
[Au] Autor:Ware JS; Wain LV; Channavajjhala SK; Jackson VE; Edwards E; Lu R; Siew K; Jia W; Shrine N; Kinnear S; Jalland M; Henry AP; Clayton J; O'Shaughnessy KM; Tobin MD; Schuster VL; Cook S; Hall IP; Glover M
[Ad] Endereço:NIHR Biomedical Research Unit in Cardiovascular Disease at Royal Brompton & Harefield, NHS Foundation Trust and Imperial College London, London, United Kingdom.
[Ti] Título:Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia.
[So] Source:J Clin Invest;127(9):3367-3374, 2017 Sep 01.
[Is] ISSN:1558-8238
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thiazide diuretics are among the most widely used treatments for hypertension, but thiazide-induced hyponatremia (TIH), a clinically significant adverse effect, is poorly understood. Here, we have studied the phenotypic and genetic characteristics of patients hospitalized with TIH. In a cohort of 109 TIH patients, those with severe TIH displayed an extended phenotype of intravascular volume expansion, increased free water reabsorption, urinary prostaglandin E2 excretion, and reduced excretion of serum chloride, magnesium, zinc, and antidiuretic hormone. GWAS in a separate cohort of 48 TIH patients and 2,922 controls from the 1958 British birth cohort identified an additional 14 regions associated with TIH. We identified a suggestive association with a variant in SLCO2A1, which encodes a prostaglandin transporter in the distal nephron. Resequencing of SLCO2A1 revealed a nonsynonymous variant, rs34550074 (p.A396T), and association with this SNP was replicated in a second cohort of TIH cases. TIH patients with the p.A396T variant demonstrated increased urinary excretion of prostaglandin E2 and metabolites. Moreover, the SLCO2A1 phospho-mimic p.A396E showed loss of transporter function in vitro. These findings indicate that the phenotype of TIH involves a more extensive metabolic derangement than previously recognized. We propose one mechanism underlying TIH development in a subgroup of patients in which SLCO2A1 regulation is altered.
[Mh] Termos MeSH primário: Hiponatremia/induzido quimicamente
Inibidores de Simportadores de Cloreto de Sódio/efeitos adversos
Tiazidas/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Aquaporina 1/genética
Aquaporina 2/genética
Estudos de Coortes
Dinoprostona/metabolismo
Feminino
Estudo de Associação Genômica Ampla
Seres Humanos
Hiponatremia/genética
Masculino
Meia-Idade
Néfrons/metabolismo
Transportadores de Ânions Orgânicos/genética
Farmacogenética
Fenótipo
Polimorfismo de Nucleotídeo Único
Prostaglandinas/metabolismo
Reino Unido
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AQP1 protein, human); 0 (AQP2 protein, human); 0 (Aquaporin 2); 0 (Organic Anion Transporters); 0 (Prostaglandins); 0 (SLCO2A1 protein, human); 0 (Sodium Chloride Symporter Inhibitors); 0 (Thiazides); 059QF0KO0R (Water); 146410-94-8 (Aquaporin 1); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170808
[St] Status:MEDLINE


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[PMID]:28430812
[Au] Autor:Tutakhel OAZ; Moes AD; Valdez-Flores MA; Kortenoeven MLA; Vrie MVD; Jelen S; Fenton RA; Zietse R; Hoenderop JGJ; Hoorn EJ; Hilbrands L; Bindels RJM
[Ad] Endereço:Department of Physiology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
[Ti] Título:NaCl cotransporter abundance in urinary vesicles is increased by calcineurin inhibitors and predicts thiazide sensitivity.
[So] Source:PLoS One;12(4):e0176220, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Animal studies have shown that the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus can activate the thiazide-sensitive NaCl cotransporter (NCC). A common side effect of CNIs is hypertension. Renal salt transporters such as NCC are excreted in urinary extracellular vesicles (uEVs) after internalization into multivesicular bodies. Human studies indicate that CNIs also increase NCC abundance in uEVs, but results are conflicting and no relationship with NCC function has been shown. Therefore, we investigated the effects of CsA and Tac on the abundance of both total NCC (tNCC) and phosphorylated NCC at Thr60 phosphorylation site (pNCC) in uEVs, and assessed whether NCC abundance in uEVs predicts the blood pressure response to thiazide diuretics. Our results show that in kidney transplant recipients treated with cyclosporine (n = 9) or tacrolimus (n = 23), the abundance of both tNCC and pNCC in uEVs is 4-5 fold higher than in CNI-free kidney transplant recipients (n = 13) or healthy volunteers (n = 6). In hypertensive kidney transplant recipients, higher abundances of tNCC and pNCC prior to treatment with thiazides predicted the blood pressure response to thiazides. During thiazide treatment, the abundance of pNCC in uEVs increased in responders (n = 10), but markedly decreased in non-responders (n = 8). Thus, our results show that CNIs increase the abundance of both tNCC and pNCC in uEVs, and these increases correlate with the blood pressure response to thiazides. This implies that assessment of NCC in uEVs could represent an alternate method to guide anti-hypertensive therapy in kidney transplant recipients.
[Mh] Termos MeSH primário: Inibidores de Calcineurina/farmacologia
Simportadores de Cloreto de Sódio/metabolismo
Tiazidas/farmacologia
[Mh] Termos MeSH secundário: Animais
Estudos de Casos e Controles
Estudos de Coortes
Seres Humanos
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcineurin Inhibitors); 0 (Sodium Chloride Symporters); 0 (Thiazides)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176220


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[PMID]:28094030
[Au] Autor:Rashmi P; Colussi G; Ng M; Wu X; Kidwai A; Pearce D
[Ad] Endereço:Division of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
[Ti] Título:Glucocorticoid-induced leucine zipper protein regulates sodium and potassium balance in the distal nephron.
[So] Source:Kidney Int;91(5):1159-1177, 2017 May.
[Is] ISSN:1523-1755
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glucocorticoid induced leucine zipper protein (GILZ) is an aldosterone-regulated protein that controls sodium transport in cultured kidney epithelial cells. Mice lacking GILZ have been reported previously to have electrolyte abnormalities. However, the mechanistic basis has not been explored. Here we provide evidence supporting a role for GILZ in modulating the balance of renal sodium and potassium excretion by regulating the sodium-chloride cotransporter (NCC) activity in the distal nephron. Gilz mice have a higher plasma potassium concentration and lower fractional excretion of potassium than wild type mice. Furthermore, knockout mice are more sensitive to NCC inhibition by thiazides than are the wild type mice, and their phosphorylated NCC expression is higher. Despite increased NCC activity, knockout mice do not have higher blood pressure than wild type mice. However, during sodium deprivation, knockout mice come into sodium balance more quickly, than do the wild type, without a significant increase in plasma renin activity. Upon prolonged sodium restriction, knockout mice develop frank hyperkalemia. Finally, in HEK293T cells, exogenous GILZ inhibits NCC activity at least in part by inhibiting SPAK phosphorylation. Thus, GILZ promotes potassium secretion by inhibiting NCC and enhancing distal sodium delivery to the epithelial sodium channel. Additionally, Gilz mice have features resembling familial hyperkalemic hypertension, a human disorder that manifests with hyperkalemia associated variably with hypertension.
[Mh] Termos MeSH primário: Néfrons/metabolismo
Potássio/sangue
Pseudo-Hipoaldosteronismo/metabolismo
Simportadores de Cloreto de Sódio/metabolismo
Sódio/sangue
Fatores de Transcrição/metabolismo
[Mh] Termos MeSH secundário: Animais
Células HEK293
Seres Humanos
Hiperpotassemia/sangue
Hipertensão/metabolismo
Masculino
Camundongos
Camundongos Knockout
Antígenos de Histocompatibilidade Menor/metabolismo
Fosforilação
Proteínas Serina-Treonina Quinases/metabolismo
Renina/sangue
Renina/metabolismo
Transdução de Sinais
Simportadores de Cloreto de Sódio/efeitos dos fármacos
Membro 3 da Família 12 de Carreador de Soluto
Tiazidas/farmacologia
Fatores de Transcrição/genética
Proteína Quinase 1 Deficiente de Lisina WNK
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dsip1 protein, mouse); 0 (Minor Histocompatibility Antigens); 0 (Sodium Chloride Symporters); 0 (Solute Carrier Family 12, Member 3); 0 (Thiazides); 0 (Transcription Factors); 9NEZ333N27 (Sodium); EC 2.7.1.- (Prkwnk4 protein, mouse); EC 2.7.1.- (Stk39 protein, mouse); EC 2.7.11.1 (Protein-Serine-Threonine Kinases); EC 2.7.11.1 (STK39 protein, human); EC 2.7.11.1 (WNK Lysine-Deficient Protein Kinase 1); EC 2.7.11.1 (Wnk1 protein, mouse); EC 3.4.23.15 (Renin); RWP5GA015D (Potassium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170118
[St] Status:MEDLINE


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[PMID]:27852221
[Au] Autor:Nilsson S; Järemo P
[Ad] Endereço:Primary Health Care and Department of Medicine and Health Sciences, Linköping University, Norrköping, Sweden. staffan.g.nilsson@liu.se.
[Ti] Título:Non-coronary chest pain does not affect long-term mortality: a prospective, observational study using a matched population control.
[So] Source:BMC Fam Pract;17(1):159, 2016 Nov 16.
[Is] ISSN:1471-2296
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chest pain assumed to be of non-coronary origin (NCCP) may be linked to enhanced mortality due to coronary heart disease (CHD). The aim of this study was to follow NCCP patients, as defined in primary care, with respect to mortality and long-term morbidity of CHD. We further examined if NCCP associates with risk factors for CHD. METHODS: Patients consulting general practitioners (GPs) in 1998-2000 in three primary care centers in the southeast Sweden for chest pain regarded as NCCP were compared with controls matched for age, gender and residential area. Causes of death were gathered from registry data and death certificates. In 2005 a postal questionnaire was distributed to the survivors to collect demographic and clinical data. If participants had CHD diagnosed by a physician prior to inclusion they were excluded. RESULTS: Patients with NCCP (n = 382) and population controls (n = 746) did not differ with respect to mortality and incidence of CHD. The NCCP group reported more ongoing chest pain (OR 3.34 95 % CI 2.41-4.62), they more often had elevated blood pressure (OR 1.86 95 % CI 1.32-2.60), consumed more ß-blockers (p < 0.001), aspirin (p = 0.013), thiazides (p = 0.004) and long-acting nitrates (p = 0.002). They further had more remedies for acid-related disorders (p = 0.014) and obstructive pulmonary disease (p < 0.001). CONCLUSIONS: The study suggests that individuals with chest pain judged by GPs to be NCCP do not develop CHD more frequently than population controls. It is evident that NCCP often lasts for many years and that the condition associates with hypertension.
[Mh] Termos MeSH primário: Causas de Morte
Dor no Peito/mortalidade
Doença das Coronárias/epidemiologia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos beta/uso terapêutico
Adulto
Idoso
Aspirina/uso terapêutico
Estudos de Casos e Controles
Dor no Peito/etiologia
Doença das Coronárias/mortalidade
Feminino
Seres Humanos
Hipertensão/epidemiologia
Incidência
Masculino
Meia-Idade
Nitratos/uso terapêutico
Inibidores da Agregação de Plaquetas/uso terapêutico
Estudos Prospectivos
Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico
Fatores de Risco
Suécia/epidemiologia
Tiazidas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Nitrates); 0 (Platelet Aggregation Inhibitors); 0 (Thiazides); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


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[PMID]:27721529
[Au] Autor:Sharma KH
[Ad] Endereço:Department of Cardiology, U.N. Mehta ICRC, B.J. Medical College, Ahmedabad, Gujarat, India E-mail: kamalcardiodoc@gmail.com.
[Ti] Título:Did all thiazides take undue credit of good work of chlorthalidone?
[So] Source:Indian J Pharmacol;48(5):479-480, 2016 Sep-Oct.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Clortalidona/uso terapêutico
Diuréticos/uso terapêutico
Hipertensão/tratamento farmacológico
Tiazidas/uso terapêutico
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Diuretics); 0 (Thiazides); Q0MQD1073Q (Chlorthalidone)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


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[PMID]:27515947
[Au] Autor:Sánchez-Larsen Á; Segura T; García-Muñozguren S; Peinado-Ródenas J; Zamarro J; Hernández-Fernández F
[Ad] Endereço:Department of Neurology, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. aa.sanchezlarsen@gmail.com.
[Ti] Título:Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium.
[So] Source:BMC Neurol;16(1):135, 2016 Aug 11.
[Is] ISSN:1471-2377
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Magnesium has a regulatory role in the excitability of cell membranes, and is also a cofactor in the phosphorylation of thiamine. Hypomagnesemia has been associated with coronary vasospasm, but its role in cerebrovascular pathology is controversial, and cerebral vasospasm exclusively attributable to hypomagnesemia has not been reported in humans. CASE PRESENTATION: We report the case of a 51-year-old man in whom uncontrollable vomiting, treatment with omeprazole and thiazide, and renal impairment lead to a severe hypomagnesemia (magnesium below the level of detection in blood tests), which secondarily caused Wernicke's encephalopathy and vasospasm in multiple cerebral arteries (seen with cerebral angiography and CT angiography) that presented with a complete right hemisphere neurological deficit. These disturbances completely resolved when magnesium levels were normalized and subsequent neuroimaging tests confirmed the resolution of angiographic changes. CONCLUSION: Our case suggests that hypomagnesemia should be considered in the differential diagnosis of patients with neurological symptoms and predisposing causes.
[Mh] Termos MeSH primário: Magnésio/sangue
Vômito/tratamento farmacológico
Encefalopatia de Wernicke/etiologia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Seres Humanos
Nefropatias/complicações
Masculino
Meia-Idade
Omeprazol/efeitos adversos
Inibidores da Bomba de Prótons/efeitos adversos
Tiazidas/efeitos adversos
Vasoespasmo Intracraniano/sangue
Vasoespasmo Intracraniano/etiologia
Vômito/complicações
Encefalopatia de Wernicke/sangue
Encefalopatia de Wernicke/diagnóstico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proton Pump Inhibitors); 0 (Thiazides); I38ZP9992A (Magnesium); KG60484QX9 (Omeprazole)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1186/s12883-016-0660-x


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[PMID]:27393629
[Au] Autor:Li X; Jin X; Yao X; Ma X; Wang Y
[Ad] Endereço:Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China.
[Ti] Título:Thioether bridged cationic cyclodextrin stationary phases: Effect of spacer length, selector concentration and rim functionalities on the enantioseparation.
[So] Source:J Chromatogr A;1467:279-287, 2016 Oct 07.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The preparation and evaluation of four single thioether bridged cationic cyclodextrin (CD) chiral stationary phases (CSPs) with different spacer length, selector concentration and rim functionalities are reported. Mono-6-(1-vinyl/allyl/butenylimidazolium)-ß-CDs chloride were synthesized and clicked onto thiol silica to form three novel cationic native-CD-CSPs (CSP1, CSP2 and CSP3) and a post-synthetic phenylcarbamoylation of CSP2 was performed affording CSP4. The enantioseparation ability of the as-prepared CSPs were evaluated in high performance liquid chromatography (HPLC) by separating over forty enantiomers including isoxazolines, dansyl amino acids, flavonoids, tröger's base, 4-chromanol, bendroflumethiazide and styrene oxide. Most of the enantiomers were well resolved with the resolution (R ) of 4NPh-OPr reaching 12.68. The effects of spacer length, selector concentration and rim functionalities on the enantioseparation were investigated. A comparison of the current CSP with a commercial column (Cyclobond I 2000) was also conducted to reveal the superiors enantioselectivity of the as-prepared CSPs.
[Mh] Termos MeSH primário: Ciclodextrinas/química
Compostos de Sulfidrila/química
Sulfetos/química
[Mh] Termos MeSH secundário: Aminoácidos/isolamento & purificação
Cátions
Cromatografia Líquida de Alta Pressão/métodos
Química Click
Flavonoides/isolamento & purificação
Isoxazóis/isolamento & purificação
Dióxido de Silício/química
Estereoisomerismo
Tiazidas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Cations); 0 (Cyclodextrins); 0 (Flavonoids); 0 (Isoxazoles); 0 (Sulfhydryl Compounds); 0 (Sulfides); 0 (Thiazides); 7631-86-9 (Silicon Dioxide)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171008
[Lr] Data última revisão:
171008
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160710
[St] Status:MEDLINE


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[PMID]:27181981
[Au] Autor:Patterson JH; Adams KF
[Ad] Endereço:Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina, Eshelman School of Pharmacy, Chapel Hill, North Carolina. Electronic address: hpatterson@unc.edu.
[Ti] Título:Investigating the Role of Thiazide-Like Diuretics in Acute Heart Failure: Potential Approach to an Unmet Need.
[So] Source:J Card Fail;22(7):537-8, 2016 07.
[Is] ISSN:1532-8414
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Diuréticos/uso terapêutico
Insuficiência Cardíaca/tratamento farmacológico
Tiazidas/uso terapêutico
[Mh] Termos MeSH secundário: Doença Aguda
Necessidades e Demandas de Serviços de Saúde
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL
[Nm] Nome de substância:
0 (Diuretics); 0 (Thiazides)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160517
[St] Status:MEDLINE


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[PMID]:27153450
[Au] Autor:Filippatos TD; Liamis G; Elisaf MS
[Ad] Endereço:a Department of Internal Medicine, School of Medicine , University of Ioannina , Ioannina , Greece.
[Ti] Título:Ten pitfalls in the proper management of patients with hyponatremia.
[So] Source:Postgrad Med;128(5):516-22, 2016 Jun.
[Is] ISSN:1941-9260
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hyponatremia (serum sodium <135 mEq/L) is a common electrolyte disorder in community or hospitalized patients. Serum sodium levels should be corrected at a proper rate in patients with hyponatremia, since overcorrection of serum sodium levels is related to devastating neurologic consequences, such as the osmotic demyelination syndrome (ODS). However, a number of pitfalls, which could lead to undercorrection or overcorrection of hyponatremia, are common during the treatment of hyponatremic patients. Hereby, we describe ten common pitfalls that are observed during the correction of serum sodium concentration in hyponatremic patients. These refer to pitfalls in the goals and limits of the correction rate of serum sodium, pitfalls in the means (e.g. solutions but also drugs) and formulas used for achieving the desired correction rate and pitfalls associated with inadequate management or overcorrection. The knowledge of these common-in-clinical-practice pitfalls could assist clinicians in the proper management of patients with hyponatremia.
[Mh] Termos MeSH primário: Diuréticos/uso terapêutico
Hidratação
Hiponatremia/sangue
Hiponatremia/terapia
Erros Médicos
Sódio/sangue
[Mh] Termos MeSH secundário: Doença Aguda
Antagonistas de Receptores de Hormônios Antidiuréticos/uso terapêutico
Doença Crônica
Cálculos da Dosagem de Medicamento
Hidratação/efeitos adversos
Furosemida/uso terapêutico
Seres Humanos
Hiponatremia/etiologia
Hipovolemia/complicações
Hipovolemia/terapia
Síndrome de Secreção Inadequada de HAD/complicações
Síndrome de Secreção Inadequada de HAD/terapia
Conceitos Matemáticos
Tiazidas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidiuretic Hormone Receptor Antagonists); 0 (Diuretics); 0 (Thiazides); 7LXU5N7ZO5 (Furosemide); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170125
[Lr] Data última revisão:
170125
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160507
[St] Status:MEDLINE
[do] DOI:10.1080/00325481.2016.1186488


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[PMID]:26987648
[Au] Autor:Sinha AD; Agarwal R
[Ad] Endereço:Indiana University School of Medicine, Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA.
[Ti] Título:Thiazides are useful agents in CKD.
[So] Source:J Am Soc Hypertens;10(4):288-9, 2016 Apr.
[Is] ISSN:1878-7436
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Anti-Hipertensivos/uso terapêutico
Taxa de Filtração Glomerular/efeitos dos fármacos
Hipertensão/tratamento farmacológico
Insuficiência Renal Crônica/tratamento farmacológico
Inibidores de Simportadores de Cloreto de Sódio/uso terapêutico
Tiazidas/uso terapêutico
[Mh] Termos MeSH secundário: Anti-Hipertensivos/efeitos adversos
Seres Humanos
Guias de Prática Clínica como Assunto
Ensaios Clínicos Controlados Aleatórios como Assunto
Inibidores de Simportadores de Cloreto de Sódio/efeitos adversos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Sodium Chloride Symporter Inhibitors); 0 (Thiazides)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE



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