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[PMID]:27773524
[Au] Autor:Viciosa MT; Moura Ramos JJ; Diogo HP
[Ad] Endereço:Centro de Química-Física Molecular and Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal.
[Ti] Título:The Slow Relaxation Dynamics in the Amorphous Pharmaceutical Drugs Cimetidine, Nizatidine, and Famotidine.
[So] Source:J Pharm Sci;105(12):3573-3584, 2016 Dec.
[Is] ISSN:1520-6017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The slow molecular mobility in the amorphous solid state of 3 active pharmaceutical drugs (cimetidine, nizatidine, and famotidine) has been studied using differential scanning calorimetry and the 2 dielectric-related techniques of dielectric relaxation spectroscopy and thermally stimulated depolarization currents. The glass-forming ability, the glass stability, and the tendency for crystallization from the equilibrium melt were investigated by differential scanning calorimetry, which also provided the characterization of the main relaxation of the 3 glass formers. The chemical instability of famotidine at the melting temperature and above it prevented the preparation of the amorphous for dielectric studies. In contrast, for cimetidine and nizatidine, the dielectric study yielded the main kinetic features of the α relaxation and of the secondary relaxations. According to the obtained results, nizatidine displays the higher fragility index of the 3 studied glass-forming drugs. The thermally stimulated depolarization current technique has proved useful to identify the Johari-Goldstein relaxation and to measure τ in the amorphous solid state, that is, in a frequency range which is not easily accessible by dielectric relaxation spectroscopy.
[Mh] Termos MeSH primário: Química Farmacêutica/métodos
Cimetidina/química
Famotidina/química
Nizatidina/química
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria/métodos
Cimetidina/metabolismo
Famotidina/metabolismo
Nizatidina/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5QZO15J2Z8 (Famotidine); 80061L1WGD (Cimetidine); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27916696
[Au] Autor:Sailaja U; Shahin Thayyil M; Krishna Kumar NS; Govindaraj G; Ngai KL
[Ad] Endereço:Department of Physics, M.E.S Keveeyam College, Valanchery, 676 552 Malappuram, Kerala, India. Electronic address: sailajaurpayil@gmail.com.
[Ti] Título:Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine.
[So] Source:Eur J Pharm Sci;99:147-151, 2017 Mar 01.
[Is] ISSN:1879-0720
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The dielectric properties of two pharmaceuticals nizatidine and perphenazine were investigated in the supercooled liquid and glassy states by broadband dielectric spectroscopy. Two relaxation processes were observed in both the pharmaceuticals. The relaxation process observed above the glass transition temperature is the structural alpha relaxation and below the glass transition temperature is the gamma relaxation of intramolecular origin. The Johari-Goldstein beta relaxation coming from the motion of the entire molecule is found to be hidden under the structural relaxation peak in both the pharmaceuticals.
[Mh] Termos MeSH primário: Nizatidina/química
Perfenazina/química
Preparações Farmacêuticas/química
[Mh] Termos MeSH secundário: Espectroscopia Dielétrica/métodos
Vidro/química
Movimento (Física)
Temperatura Ambiente
Temperatura de Transição
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); FTA7XXY4EZ (Perphenazine); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170526
[Lr] Data última revisão:
170526
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27872516
[Au] Autor:Qin Z; Fu Q; Zhang L; Yin H; Jin X; Tang Q; Lyu D; Yao K
[Ad] Endereço:Eye Center of the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, Zhejiang, China.
[Ti] Título:Proliferative Effects of Histamine on Primary Human Pterygium Fibroblasts.
[So] Source:Mediators Inflamm;2016:9862496, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:. It has been confirmed that inflammatory cytokines are involved in the progression of pterygium. Histamine can enhance proliferation and migration of many cells. Therefore, we intend to investigate the proliferative and migratory effects of histamine on primary culture of human pterygium fibroblasts (HPFs). . Pterygium and conjunctiva samples were obtained from surgery, and toluidine blue staining was used to identify mast cells. 3-[4, 5-Dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) was performed to evaluate the proliferative rate of HPFs and human conjunctival fibroblasts (HCFs); ki67 expression was also measured by immunofluorescence analysis. Histamine receptor-1 (H1R) antagonist (Diphenhydramine Hydrochloride) and histamine receptor-2 (H2R) antagonist (Nizatidine) were added to figure out which receptor was involved. Wound healing model was used to evaluate the migratory ability of HPFs. . The numbers of total mast cells and degranulated mast cells were both higher in pterygium than in conjunctiva. Histamine had a proliferative effect on both HPFs and HCFs, the effective concentration (10 mol/L) on HPFs was lower than on HCFs (100 mol/L), and the effect could be blocked by H1R antagonist. Histamine showed no migratory effect on HPFs. . Histamine may play an important role in the proliferation of HPFs and act through H1R.
[Mh] Termos MeSH primário: Fibroblastos/efeitos dos fármacos
Fibroblastos/metabolismo
Histamina/farmacologia
Pterígio/patologia
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Células Cultivadas
Túnica Conjuntiva/citologia
Difenidramina/farmacologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
Seres Humanos
Mastócitos/efeitos dos fármacos
Mastócitos/metabolismo
Nizatidina/farmacologia
Reação em Cadeia da Polimerase em Tempo Real
Soro/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histamine H1 Antagonists); 820484N8I3 (Histamine); 8GTS82S83M (Diphenhydramine); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


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[PMID]:27608003
[Au] Autor:Yin H; Wang R; Wan J; Zheng Y; Ouyang D; Wang R
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. hyin531@outlook.com.
[Ti] Título:Molecular Encapsulation of Histamine H2-Receptor Antagonists by Cucurbit[7]Uril: An Experimental and Computational Study.
[So] Source:Molecules;21(9), 2016 Sep 06.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The histamine H2-receptor antagonists cimetidine, famotidine and nizatidine are individually encapsulated by macrocyclic cucurbit[7]uril (CB[7]), with binding affinities of 6.57 (±0.19) × 10³ M(-1), 1.30 (±0.27) × 104 M(-1) and 1.05 (±0.33) × 105 M(-1), respectively. These 1:1 host-guest inclusion complexes have been experimentally examined by ¹H-NMR, UV-visible spectroscopic titrations (including Job plots), electrospray ionization mass spectrometry (ESI-MS), and isothermal titration calorimetry (ITC), as well as theoretically by molecular dynamics (MD) computation. This study may provide important insights on the supramolecular formulation of H2-receptor antagonist drugs for potentially enhanced stability and controlled release based on different binding strengths of these host-guest complexes.
[Mh] Termos MeSH primário: Hidrocarbonetos Aromáticos com Pontes/química
Cimetidina/química
Famotidina/química
Antagonistas dos Receptores Histamínicos H2/química
Imidazóis/química
Simulação de Dinâmica Molecular
Nizatidina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bridged-Ring Compounds); 0 (Histamine H2 Antagonists); 0 (Imidazoles); 0 (cucurbit(7)uril); 5QZO15J2Z8 (Famotidine); 80061L1WGD (Cimetidine); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE


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[PMID]:26714298
[Au] Autor:Wang X; Zhou B; Yang H; Wang X; Xie Y
[Ad] Endereço:Department of Environmental Engineering, School of Civil and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China.
[Ti] Título:Effect of oxidation on nitro-based pharmaceutical degradation and trichloronitromethane formation.
[So] Source:Chemosphere;146:154-61, 2016 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nitro-based compounds are the direct precursors of trichloronitromethane during chlorination disinfection. Two nitro-based pharmaceuticals ranitidine and nizatidine were selected as model compounds to assess the effect of oxidation on the removal of nitro-based pharmaceuticals, as well as the reduction of their trichloronitromethane formation potentials (TCNMFPs). The four oxidants were ozone (O3), chlorine (Cl2), chlorine dioxide (ClO2) and potassium permanganate (KMnO4). The changes in pharmaceuticals and their TCNMFPs during oxidation using various oxidants and dosages were quantified. The relationships between oxidation product structures and TCNMFP changes were also analyzed. The results showed that oxidation with Cl2 and KMnO4 were more effective than ClO2 and O3 in removing the nitro-based pharmaceuticals. Meanwhile, decreased TCNMFPs by KMnO4 oxidation but increased TCNMFPs by Cl2, ClO2 and O3 oxidation were observed. The results of product analysis indicated that chlorine transfer products had higher TCNMFPs, while oxygen transfer products made little contribution to TCNMFPs after oxidation. In addition, one possible reaction pathway leading TCNMFP increase was that chloro-nitromethane or nitromethane, which was a better TCNM precursor, formed when double bond was attacked by oxidants.
[Mh] Termos MeSH primário: Hidrocarbonetos Clorados/análise
Nizatidina/química
Oxidantes/química
Ranitidina/química
Poluentes Químicos da Água/química
Purificação da Água
[Mh] Termos MeSH secundário: Desinfetantes/química
Monitoramento Ambiental
Oxirredução
Preparações Farmacêuticas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Disinfectants); 0 (Hydrocarbons, Chlorinated); 0 (Oxidants); 0 (Pharmaceutical Preparations); 0 (Water Pollutants, Chemical); 884KT10YB7 (Ranitidine); I4JTX7Z7U2 (chloropicrin); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160123
[Lr] Data última revisão:
160123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151230
[St] Status:MEDLINE


  6 / 311 MEDLINE  
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[PMID]:26538490
[Au] Autor:Elshaboury SR; Mohamed NA; Ahmed S; Farrag S
[Ad] Endereço:Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
[Ti] Título:An Efficient Ion-Pair Liquid Chromatographic Method for the Determination of Some H2 Receptor Antagonists.
[So] Source:J Chromatogr Sci;54(3):419-28, 2016 Mar.
[Is] ISSN:1945-239X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple, efficient and reliable ion-pair chromatography (IPC) method was developed and validated for the determination of some H2 receptor antagonists including ranitidine (RAN), nizatidine (NIZ) and famotidine (FAM). The use of IPC separations provided improved peak resolution with good peak shape in short analysis time and augmented method selectivity compared with the frequently used RP-C18 methods. A simple isocratic mode with mobile phase containing acetonitrile and 20 mM acetate buffer (50 : 50, v/v) containing 20 mM sodium dodecyl sulfate was used for separation. The flow rate was set at 1.0 mL min(-1), and the effluent was monitored by UV detector at 280 nm FAM and 320 nm for NIZ and RAN. The method was validated in accordance with International Conference on Harmonization guidelines and shown to be suitable for intended applications. The limits of detections and quantitations were 0.008-0.011 and 0.025-0.033 µg mL(-1), respectively. The proposed IPC method was successfully applied for the determination of pharmaceutical dosage forms without prior need for separation. Additionally, the developed method was applied for the determination of RAN in rabbit plasma using NIZ as the internal standard. The method entailed direct injection of the plasma samples after deproteination using methanol. Finally, the proposed IPC method was applied successfully in a pharmacokinetic study for RAN in rabbits after a single oral dose of RAN.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Famotidina/farmacocinética
Antagonistas dos Receptores Histamínicos H2/farmacocinética
Nizatidina/farmacocinética
Ranitidina/farmacocinética
[Mh] Termos MeSH secundário: Acetonitrilos
Administração Oral
Animais
Tampões (Química)
Cromatografia Líquida de Alta Pressão/normas
Famotidina/sangue
Feminino
Antagonistas dos Receptores Histamínicos H2/sangue
Seres Humanos
Limite de Detecção
Nizatidina/sangue
Coelhos
Ranitidina/sangue
Dodecilsulfato de Sódio
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Buffers); 0 (Histamine H2 Antagonists); 0 (Solvents); 368GB5141J (Sodium Dodecyl Sulfate); 5QZO15J2Z8 (Famotidine); 884KT10YB7 (Ranitidine); P41PML4GHR (Nizatidine); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151106
[St] Status:MEDLINE
[do] DOI:10.1093/chromsci/bmv159


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[PMID]:26507723
[Au] Autor:Morrissey KM; Stocker SL; Chen EC; Castro RA; Brett CM; Giacomini KM
[Ad] Endereço:Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
[Ti] Título:The Effect of Nizatidine, a MATE2K Selective Inhibitor, on the Pharmacokinetics and Pharmacodynamics of Metformin in Healthy Volunteers.
[So] Source:Clin Pharmacokinet;55(4):495-506, 2016 Apr.
[Is] ISSN:1179-1926
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVES: In the proximal tubule, basic drugs are transported from the renal cells to the tubule lumen through the concerted action of the H(+)/organic cation antiporters, multidrug and toxin extrusion (MATE) 1 and MATE2K. Dual inhibitors of the MATE transporters have been shown to have a clinically relevant effect on the pharmacokinetics of concomitantly administered basic drugs. However, the clinical impact of selective renal organic cation transport inhibition on the pharmacokinetics and pharmacodynamics of basic drugs, such as metformin, is unknown. This study sought to identify a selective MATE2K inhibitor in vitro and to determine its clinical impact on the pharmacokinetics and pharmacodynamics of metformin in healthy subjects. METHODS: Strategic cell-based screening of 71 US Food and Drug Administration (FDA)-approved medications was conducted to identify selective inhibitors of renal organic cation transporters that are capable of inhibiting at clinically relevant concentrations. From this screen, nizatidine was identified and predicted to be a clinically potent and selective inhibitor of MATE2K-mediated transport. The effect of nizatidine on the pharmacokinetics and pharmacodynamics of metformin was evaluated in 12 healthy volunteers in an open-label, randomized, two-phase crossover drug-drug interaction (DDI) study. RESULTS: In healthy volunteers, the MATE2K-selective inhibitor nizatidine significantly increased the apparent volume of distribution, half-life, and hypoglycemic activity of metformin. However, despite achieving unbound maximum concentrations greater than the in vitro inhibition potency (concentration of drug producing 50% inhibition [IC50]) of MATE2K-mediated transport, nizatidine did not affect the renal clearance (CLR) or net secretory clearance of metformin. CONCLUSION: This study demonstrates that a selective inhibition of MATE2K by nizatidine affected the apparent volume of distribution, tissue concentrations, and peripheral effects of metformin. However, nizatidine did not alter systemic concentrations or the CLR of metformin, suggesting that specific MATE2K inhibition may not be sufficient to cause renal DDIs with metformin.
[Mh] Termos MeSH primário: Metformina/farmacologia
Metformina/farmacocinética
Nizatidina/farmacologia
Proteínas de Transporte de Cátions Orgânicos/antagonistas & inibidores
[Mh] Termos MeSH secundário: Adolescente
Adulto
Linhagem Celular
Estudos Cross-Over
Interações Medicamentosas
Feminino
Células HEK293
Meia-Vida
Seres Humanos
Hipoglicemiantes/farmacocinética
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
Rim/metabolismo
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Hypoglycemic Agents); 0 (MATE2-K protein, human); 0 (Organic Cation Transport Proteins); 9100L32L2N (Metformin); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151029
[St] Status:MEDLINE
[do] DOI:10.1007/s40262-015-0332-9


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[PMID]:26197435
[Au] Autor:Shang DW; Wang ZZ; Ni XJ; Zhang M; Hu JQ; Qiu C; Wen YG
[Ad] Endereço:Department of Pharmacy, Guangzhou Brain Hospital, Guangzhou Medical University, 36 Mingxin Road, Guangzhou 510370, China.
[Ti] Título:Development and validation of a sensitive LC-MS/MS assay for the quantification of nizatidine in human plasma and urine and its application to pharmacokinetic study.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;998-999:80-7, 2015 Aug 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:We developed and validated a high performance liquid chromatographic method coupled with triple quadrupole mass spectrometry for analysis of nizatidine in human plasma and urine. The biological samples were precipitated with methanol before separation on an Agilent Eclipse Plus C18 column (100mm×46mm, 5µm) with a mixture of methanol and water (95:5, plus 5mM ammonium formate) as the mobile phase at 0.5mL/min. Detection was performed using multiple reaction monitoring modes via electrospray ionization (ESI) at m/z 332.1→155.1 (for nizatidine) and m/z 335.1→155.1 (for [(2)H3]-nizatidine, the internal standard). The linear response range was 5-2000ng/mL and 0.5-80µg/mL for human plasma and urine, with the lower limits of quantification of 5ng/mL and 0.5µg/mL, respectively. The method was validated according to the biological method validation guidelines of the Food and Drug Administration and proved acceptable. This newly developed analytical method was successfully applied in a pharmacokinetic study following single oral administration of a 150mg nizatidine capsule in to 16 healthy Chinese subjects. Maximum and endpoint concentrations in plasma and urine were quantifiable, suggesting our method is appropriate for routine pharmacokinetic analysis.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Antagonistas dos Receptores Histamínicos H2/sangue
Antagonistas dos Receptores Histamínicos H2/urina
Nizatidina/sangue
Nizatidina/urina
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Antagonistas dos Receptores Histamínicos H2/farmacocinética
Seres Humanos
Masculino
Nizatidina/farmacocinética
Sensibilidade e Especificidade
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Histamine H2 Antagonists); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150805
[Lr] Data última revisão:
150805
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150722
[St] Status:MEDLINE


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[PMID]:25688620
[Au] Autor:Sakakibara R; Doi H; Sato M; Hirai S; Masaka T; Kishi M; Tsuyusaki Y; Tateno A; Tateno F; Aiba Y; Ogata T; Suzuki Y
[Ad] Endereço:Division of Neurology, Department of Internal Medicine, Sakura Medical Center, Toho University, Sakura, Japan.
[Ti] Título:Nizatidine ameliorates slow transit constipation in Parkinson's disease.
[So] Source:J Am Geriatr Soc;63(2):399-401, 2015 Feb.
[Is] ISSN:1532-5415
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Constipação Intestinal/tratamento farmacológico
Constipação Intestinal/etiologia
Trânsito Gastrointestinal/efeitos dos fármacos
Antagonistas dos Receptores Histamínicos H2/uso terapêutico
Nizatidina/uso terapêutico
Doença de Parkinson/complicações
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Feminino
Trânsito Gastrointestinal/fisiologia
Seres Humanos
Masculino
[Pt] Tipo de publicação:CLINICAL TRIAL; LETTER
[Nm] Nome de substância:
0 (Histamine H2 Antagonists); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150218
[Lr] Data última revisão:
150218
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150218
[St] Status:MEDLINE
[do] DOI:10.1111/jgs.13279


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[PMID]:25498149
[Au] Autor:Kiszkiel I; Starczewska B; Lesniewska B; Pózniak P
[Ad] Endereço:University of Bialystok, Institute of Chemistry, Hurtowa 1, 15-399 Bialystok, Poland. Electronic address: i.kiszkiel@interia.eu.
[Ti] Título:Extraction of ranitidine and nizatidine with using imidazolium ionic liquids prior spectrophotometric and chromatographic detection.
[So] Source:J Pharm Biomed Anal;106:85-91, 2015 Mar 15.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new extraction medium was proposed for liquid-liquid extraction of the histamine H2 receptor antagonists ranitidine (RNT) and nizatidine (NZT). The ionic liquids with low vapor pressure and favorable solvating properties for a range of compounds such as 1-butyl-3-methylimidazolium hexafluorophosphate [C4mim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [C4mim][Tf2N] were tested for isolation of analytes. The extraction parameters of RNT and NZT, namely, amount of ionic liquid, pH of sample solution, shaking and centrifugation time were optimized. The isolation processes were performed with 1 mL of the ionic liquids. The extracted samples (pH values near 4) were shaken at 1750 rpm. The influence of interfering substances on the efficiency of extraction process was also studied. Methods for the histamine H2 receptor antagonists (ranitidine and nizatidine) determination after their separation using imidazolium ionic liquids by high performance liquid chromatography (HPLC) combined with UV spectrophotometry were developed. The application of ionic liquids in extraction step allows for selective isolation of analytes from aqueous matrices and their preconcentration. The above methods were applied to the determination of RNT and NZT in environmental samples (river water and wastewater after treatment).
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Nizatidina/análise
Ranitidina/análise
Espectrofotometria Ultravioleta/métodos
[Mh] Termos MeSH secundário: Água Doce/análise
Antagonistas dos Receptores Histamínicos H2/análise
Imidazóis/química
Líquidos Iônicos/química
Extração Líquido-Líquido/métodos
Águas Residuais/análise
Poluentes Químicos da Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Histamine H2 Antagonists); 0 (Imidazoles); 0 (Ionic Liquids); 0 (Waste Water); 0 (Water Pollutants, Chemical); 884KT10YB7 (Ranitidine); P41PML4GHR (Nizatidine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150304
[Lr] Data última revisão:
150304
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE



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