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[PMID]:27809982
[Au] Autor:Sallé G; Cortet J; Koch C; Gascogne T; Reigner F; Cabaret J
[Ad] Endereço:UMR1282 ISP, INRA, Université de Tours, 37380, Nouzilly, France. Electronic address: Guillaume.Salle@tours.inra.fr.
[Ti] Título:Ivermectin failure in the control of Oxyuris equi in a herd of ponies in France.
[So] Source:Vet Parasitol;229:73-75, 2016 Oct 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Drug resistance in equine gastro-intestinal parasitic nematodes has been reported throughout the world. While the focus is usually put on cyathostomins, observations of macrocylic lactone failure against Oxyuris equi have accumulated over the last decade. Here we report the failure of ivermectin in the control of O. equi in an experimental Welsh pony herd. In a first trial, 6 ponies previously drenched with moxidectin and showing patent O. equi infections were administered ivermectin and subsequently monitored for O. equi egg excretion over one month. This trial demonstrated a failure of ivermectin to control O. equi egg excretion as half of ponies demonstrated recurrent egg excretion in the peri-anal region during 21days after treatment. One year later, six female Welsh ponies drenched with moxidectin demonstrated signs of itching and scratching in their peri-anal region with worms being found transiently in fecal materials three weeks later. Ponies were allocated to three treatment groups, i.e. ivermectin, pyrantel embonate and fenbendazole and monitored for egg excretion over five weeks. Fenbendazole and pyrantel embonate broke ivermectin suboptimal efficacy as soon as 8 and 14days respectively after treatment, while egg excretion remained constant throughout the 41-day long trial in the ivermectin-treated ponies. This is the first report of ivermectin failure against O. equi in France. In the absence of critical efficacy test, it remains unclear whether true resistance is at stake or if these observations confound a constitutive suboptimal efficacy of ivermectin against O. equi.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Resistência a Medicamentos
Enterobíase/veterinária
Enterobius
Doenças dos Cavalos/tratamento farmacológico
Ivermectina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/administração & dosagem
Enterobíase/tratamento farmacológico
Enterobíase/parasitologia
Enterobius/efeitos dos fármacos
Feminino
Fenbendazol/administração & dosagem
Fenbendazol/uso terapêutico
França/epidemiologia
Doenças dos Cavalos/epidemiologia
Doenças dos Cavalos/parasitologia
Cavalos
Ivermectina/administração & dosagem
Ivermectina/farmacologia
Pamoato de Pirantel/administração & dosagem
Pamoato de Pirantel/uso terapêutico
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 621BVT9M36 (Fenbendazole); 70288-86-7 (Ivermectin); 81BK194Z5M (Pyrantel Pamoate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170827
[Lr] Data última revisão:
170827
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27501844
[Au] Autor:Mathison BA; Bishop HS; Sanborn CR; Dos Santos Souza S; Bradbury R
[Ad] Endereço:Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention.
[Ti] Título:Macracanthorhynchus ingens Infection in an 18-Month-Old Child in Florida: A Case Report and Review of Acanthocephaliasis in Humans.
[So] Source:Clin Infect Dis;63(10):1357-1359, 2016 Nov 15.
[Is] ISSN:1537-6591
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A case of acanthocephaliasis in an 18-month-old child caused by Macracanthorhynchus ingens is reported from Florida. This represents only the third documented case of this species in a human host. An overview of human cases of acanthocephaliasis in the literature is presented, along with a review of the biology, clinical manifestations and pathology in the human host, morphology, and diagnosis.
[Mh] Termos MeSH primário: Acantocéfalos
Helmintíase
Enteropatias Parasitárias
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/uso terapêutico
Fezes/parasitologia
Feminino
Florida
Helmintíase/diagnóstico
Helmintíase/tratamento farmacológico
Helmintíase/parasitologia
Seres Humanos
Lactente
Enteropatias Parasitárias/diagnóstico
Enteropatias Parasitárias/tratamento farmacológico
Enteropatias Parasitárias/parasitologia
Pamoato de Pirantel/uso terapêutico
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anthelmintics); 81BK194Z5M (Pyrantel Pamoate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


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[PMID]:27480864
[Au] Autor:Cowan N; Vargas M; Keiser J
[Ad] Endereço:Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland.
[Ti] Título:In Vitro and In Vivo Drug Interaction Study of Two Lead Combinations, Oxantel Pamoate plus Albendazole and Albendazole plus Mebendazole, for the Treatment of Soil-Transmitted Helminthiasis.
[So] Source:Antimicrob Agents Chemother;60(10):6127-33, 2016 Oct.
[Is] ISSN:1098-6596
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The current treatments against Trichuris trichiura, albendazole and mebendazole, are only poorly efficacious. Therefore, combination chemotherapy was recommended for treating soil-transmitted helminthiasis. Albendazole-mebendazole and albendazole-oxantel pamoate have shown promising results in clinical trials. However, in vitro and in vivo drug interaction studies should be performed before their simultaneous treatment can be recommended. Inhibition of human recombinant cytochromes P450 (CYPs) CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4 was tested by exposure to albendazole, albendazole sulfoxide, mebendazole, and oxantel pamoate, as well as albendazole-mebendazole, albendazole sulfoxide-mebendazole, albendazole-oxantel pamoate, and albendazole sulfoxide-oxantel pamoate. A high-pressure liquid chromatography (HPLC)-UV/visible spectroscopy method was developed and validated for simultaneous quantification of albendazole sulfoxide, albendazole sulfone, mebendazole, and oxantel pamoate in plasma. Albendazole, mebendazole, oxantel pamoate, albendazole-mebendazole, and albendazole-oxantel pamoate were orally applied to rats (100 mg/kg) and pharmacokinetic parameters calculated. CYP1A2 showed a 2.6-fold increased inhibition by albendazole-oxantel pamoate (50% inhibitory concentration [IC50] = 3.1 µM) and a 3.9-fold increased inhibition by albendazole sulfoxide-mebendazole (IC50 = 3.8 µM) compared to the single drugs. In rats, mebendazole's area under the concentration-time curve (AUC) and maximal plasma concentration (Cmax) were augmented 3.5- and 2.8-fold, respectively (P = 0.02 for both) when coadministered with albendazole compared to mebendazole alone. Albendazole sulfone was slightly affected by albendazole-mebendazole, displaying a 1.3-fold-elevated AUC compared to albendazole alone. Oxantel pamoate could not be quantified, translating to a bioavailability below 0.025% in rats. Elevated plasma levels of albendazole sulfoxide, albendazole sulfone, and mebendazole in coadministrations are probably not mediated by CYP-based drug-drug interaction. Even though this study indicates that it is safe to coadminister albendazole-oxantel pamoate and albendazole-mebendazole, human pharmacokinetic studies are recommended.
[Mh] Termos MeSH primário: Albendazol/farmacocinética
Anti-Helmínticos/farmacocinética
Mebendazol/farmacocinética
Pamoato de Pirantel/análogos & derivados
Tricuríase/tratamento farmacológico
Trichuris/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Oral
Albendazol/sangue
Animais
Anti-Helmínticos/sangue
Área Sob a Curva
Sistema Enzimático do Citocromo P-450/genética
Sistema Enzimático do Citocromo P-450/metabolismo
Combinação de Medicamentos
Interações Medicamentosas
Expressão Gênica
Isoenzimas/genética
Isoenzimas/metabolismo
Mebendazol/sangue
Camundongos
Testes de Sensibilidade Microbiana
Pamoato de Pirantel/sangue
Pamoato de Pirantel/farmacocinética
Ratos
Ratos Sprague-Dawley
Solo/parasitologia
Tricuríase/sangue
Tricuríase/parasitologia
Tricuríase/transmissão
Trichuris/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Drug Combinations); 0 (Isoenzymes); 0 (Soil); 81BK194Z5M (Pyrantel Pamoate); 81G6I5V05I (Mebendazole); 9035-51-2 (Cytochrome P-450 Enzyme System); F4216019LN (Albendazole); UPY1D732T0 (oxantel pamoate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1128/AAC.01217-16


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[PMID]:27450724
[Au] Autor:Kaya D; Yoshikawa M; Nakatani T; Tomo-Oka F; Fujimoto Y; Ishida K; Fujinaga Y; Aihara Y; Nagamatsu S; Matsuo E; Tokoro M; Ouji Y; Kikuchi E
[Ad] Endereço:Department of Gastroenterology, Nara Prefecture General Medical Center, 1-30-1 Hiramatsu-cho, Nara 631-0846, Japan.
[Ti] Título:Ancylostoma ceylanicum hookworm infection in Japanese traveler who presented chronic diarrhea after return from Lao People's Democratic Republic.
[So] Source:Parasitol Int;65(6 Pt A):737-740, 2016 Dec.
[Is] ISSN:1873-0329
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ancylostoma (A.) ceylanicum, one of the most common species of hookworms infecting dogs and cats, also causes patent infections in humans and is now considered to be the second most common hookworm species infecting populations in southeast Asia. A Japanese patient who returned from a visit to Thailand and Lao People's Democratic Republic (PDR) was presented with intermittent watery diarrhea with eosinophilia. Hookworm eggs were found in feces samples, and adult worms were confirmed to be present in the jejunum with capsule endoscopy and double balloon enteroscopy. A diagnosis of A. ceylanicum infection was made based on the morphology of the adult worms along with findings of a PCR-based molecular study using larvae obtained from a fecal sample culture. The infection was considered likely to have been obtained during a 1-month stay in a Laotian village, where the patient had eaten local food, worn sandals on bare feet, and lived as a local native villager, though he had stayed in modern hotels during the visit to Thailand.
[Mh] Termos MeSH primário: Ancylostoma/isolamento & purificação
Ancilostomíase/diagnóstico
Ancilostomíase/tratamento farmacológico
Antinematódeos/uso terapêutico
Pamoato de Pirantel/uso terapêutico
[Mh] Termos MeSH secundário: Ancylostoma/genética
Ancilostomíase/parasitologia
Animais
Endoscopia por Cápsula
Gatos
Cães
Enteroscopia de Duplo Balão
Eosinofilia/parasitologia
Fezes/parasitologia
Seres Humanos
Japão
Laos
Masculino
Meia-Idade
Reação em Cadeia da Polimerase
Viagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 81BK194Z5M (Pyrantel Pamoate)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27010285
[Au] Autor:Sim RR; Allender MC; Crawford LK; Wack AN; Murphy KJ; Mankowski JL; Bronson E
[Ti] Título:RANAVIRUS EPIZOOTIC IN CAPTIVE EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA) WITH CONCURRENT HERPESVIRUS AND MYCOPLASMA INFECTION: MANAGEMENT AND MONITORING.
[So] Source:J Zoo Wildl Med;47(1):256-70, 2016 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Frog virus 3 (FV3) and FV3-like viruses are members of the genus Ranavirus (family Iridoviridae) and are becoming recognized as significant pathogens of eastern box turtles (Terrapene carolina carolina) in North America. In July 2011, 5 turtles from a group of 27 in Maryland, USA, presented dead or lethargic with what was later diagnosed as fibrinonecrotic stomatitis and cloacitis. The presence of FV3-like virus and herpesvirus was detected by polymerase chain reaction (PCR) in the tested index cases. The remaining 22 animals were isolated, segregated by severity of clinical signs, and treated with nutritional support, fluid therapy, ambient temperature management, antibiotics, and antiviral therapy. Oral swabs were tested serially for FV3-like virus by quantitative real-time PCR (qPCR) and tested at day 0 for herpesvirus and Mycoplasma sp. by conventional PCR. With oral swabs, 77% of the 22 turtles were FV3-like virus positive; however, qPCR on tissues taken during necropsy revealed the true prevalence was 86%. FV3-like virus prevalence and the median number of viral copies being shed significantly declined during the outbreak. The prevalence of herpesvirus and Mycoplasma sp. by PCR of oral swabs at day 0 was 55% and 68%, respectively. The 58% survival rate was higher than previously reported in captive eastern box turtles for a ranavirus epizootic. All surviving turtles brumated normally and emerged the following year with no clinical signs during subsequent monitoring. The immediate initiation of treatment and intensive supportive care were considered the most important contributing factors to the successful outcome in this outbreak.
[Mh] Termos MeSH primário: Infecções por Vírus de DNA/veterinária
Herpesviridae/isolamento & purificação
Infecções por Mycoplasma/veterinária
Mycoplasma/isolamento & purificação
Ranavirus/isolamento & purificação
Tartarugas
[Mh] Termos MeSH secundário: 2-Aminopurina/administração & dosagem
2-Aminopurina/análogos & derivados
2-Aminopurina/uso terapêutico
Animais
Animais de Zoológico
Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Antinematódeos/administração & dosagem
Antinematódeos/uso terapêutico
Antivirais/administração & dosagem
Antivirais/uso terapêutico
Ceftazidima/administração & dosagem
Ceftazidima/uso terapêutico
Infecções por Vírus de DNA/complicações
Infecções por Vírus de DNA/tratamento farmacológico
Infecções por Vírus de DNA/virologia
Surtos de Doenças/veterinária
Feminino
Masculino
Infecções por Mycoplasma/complicações
Infecções por Mycoplasma/tratamento farmacológico
Pamoato de Pirantel/administração & dosagem
Pamoato de Pirantel/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antinematodal Agents); 0 (Antiviral Agents); 452-06-2 (2-Aminopurine); 81BK194Z5M (Pyrantel Pamoate); 9M416Z9QNR (Ceftazidime); QIC03ANI02 (famciclovir)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE
[do] DOI:10.1638/2015-0048.1


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[PMID]:26388170
[Au] Autor:Maheu-Giroux M
[Ad] Endereço:Department of Infectious Disease Epidemiology, Imperial College London, London, UK. Electronic address: m.maheu-giroux@imperial.ac.uk.
[Ti] Título:Oxantel pamoate and deworming programmes.
[So] Source:Lancet Infect Dis;16(1):5-6, 2016 Jan.
[Is] ISSN:1474-4457
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antinematódeos/uso terapêutico
Pamoato de Pirantel/análogos & derivados
Tricuríase/tratamento farmacológico
Trichuris
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antinematodal Agents); 81BK194Z5M (Pyrantel Pamoate)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE


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[PMID]:26388169
[Au] Autor:Moser W; Ali SM; Ame SM; Speich B; Puchkov M; Huwyler J; Albonico M; Hattendorf J; Keiser J
[Ad] Endereço:Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland.
[Ti] Título:Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study.
[So] Source:Lancet Infect Dis;16(1):53-60, 2016 Jan.
[Is] ISSN:1474-4457
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Commonly used drugs for preventive chemotherapy against soil-transmitted helminths (ie, albendazole and mebendazole) show low efficacy against Trichuris trichiura. Recent studies with oxantel pamoate revealed good cure rates and high egg-reduction rates against T trichiura. We aimed to assess the nature of the dose-response relation to determine the optimum dose. METHODS: We did a parallel, randomised, placebo-controlled, single-blind trial with oxantel pamoate in school-aged children (aged 6-14 years) infected with T trichiura on Pemba Island, Tanzania. Children were asked to provide two stool samples and children positive for T trichiura were eligible to participate in the trial. Children were excluded if they suffered from any systematic illness. Children were randomly assigned to six different oxantel pamoate doses (5-30 mg/kg) or a placebo. Randomisation was stratified by baseline infection intensity using random block sizes of seven and 14. The primary endpoints were cure rates and egg-reduction rates against T trichiura, both analysed by available case. Drug safety was assessed 2 h and 24 h after treatment. The trial is registered at www.isrctn.com, number ISRCTN86603231. FINDINGS: Between Oct 14, and Nov 28, 2014, we enrolled 480 participants and randomly assigned 350 children to the different oxantel pamoate doses or the placebo. 5 mg/kg oxantel pamoate was the minimum effective dose (10 of 46 children cured [cure rate 22%, 95% CI 11-36]; egg-reduction rate 85·0%, 64·5-92·9). An increased probability of being cured and reduced egg counts with escalating doses was recorded. At 25 mg/kg oxantel pamoate 27 of 45 children were cured (cure rate 60%, 95% CI 44-65) with an egg-reduction rate of 97·5% (94·4-98·9), and at 30 mg/kg 27 of 46 children were cured (59%, 43-73) with an egg-reduction rate of 98·8% (96·8-99·6). Oxantel pamoate was well tolerated across all treatment groups; only mild adverse events were reported by the participants 2 h (27 [10%]) and 24 h (12 [4%]) after treatment. INTERPRETATION: Our dose-finding study revealed an excellent tolerability profile of oxantel pamoate in children infected with T trichiura. An optimum therapeutic dose range of 15-30 mg/kg oxantel pamoate was defined. With a weight independent dose of 500 mg oxantel pamoate 95% of children aged 7-14 years in sub-Saharan Africa would receive doses of 11·7-32·0 mg/kg. Future research should include studies with oxantel pamoate in younger children and on different continents with the ultimate goal to be able to add oxantel pamoate to soil-transmitted helminth control programmes. FUNDING: Swiss National Science Foundation.
[Mh] Termos MeSH primário: Antinematódeos/uso terapêutico
Pamoato de Pirantel/análogos & derivados
Tricuríase/tratamento farmacológico
Trichuris
[Mh] Termos MeSH secundário: Adolescente
Animais
Antinematódeos/efeitos adversos
Criança
Relação Dose-Resposta a Droga
Fezes/parasitologia
Feminino
Seres Humanos
Masculino
Pamoato de Pirantel/efeitos adversos
Pamoato de Pirantel/uso terapêutico
Método Simples-Cego
Tanzânia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antinematodal Agents); 81BK194Z5M (Pyrantel Pamoate); UPY1D732T0 (oxantel pamoate)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE


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[PMID]:26214675
[Au] Autor:White ZL; Chu MW; Hood RJ
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, 600 Gresham Dr., Suite 1100, Norfolk, VA 23507. zrriaw@gmail.com.
[Ti] Título:Nasal myiasis: A case report.
[So] Source:Ear Nose Throat J;94(7):E24-5, 2015 Jul.
[Is] ISSN:1942-7522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nasal myiasis is a rare condition, with only a few reported cases and no treatment consensus. We propose a conservative treatment approach with saline irrigation and debridement. Two patients in the ICU of Norfolk General Hospital, a tertiary academic referral center, presented simultaneously with nasal myiasis. Both patients were negative for necrotic masses or tumors, and neither patient had any contributory medical comorbidities. Both patients were treated conservatively with a single dose of pyrantel pamoate, daily sinus irrigation with saline, and daily bedside endoscopic debridement. After 2 days, the nasal myiasis resolved, and both patients recovered without sequelae. We conclude that this conservative, nonsurgical approach to management is both safe and effective.
[Mh] Termos MeSH primário: Miíase/terapia
Cavidade Nasal/parasitologia
Doenças Nasais/parasitologia
Doenças Nasais/terapia
[Mh] Termos MeSH secundário: Adulto
Antiparasitários/uso terapêutico
Terapia Combinada
Desbridamento/métodos
Endoscopia
Feminino
Seres Humanos
Masculino
Meia-Idade
Pamoato de Pirantel/uso terapêutico
Cloreto de Sódio/uso terapêutico
Irrigação Terapêutica
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiparasitic Agents); 451W47IQ8X (Sodium Chloride); 81BK194Z5M (Pyrantel Pamoate)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150728
[St] Status:MEDLINE


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[PMID]:26104502
[Au] Autor:Klausz G; Keller É; Sára Z; Székely-Körmöczy P; Laczay P; Ary K; Sótonyi P; Róna K
[Ad] Endereço:Department of Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary.
[Ti] Título:Simultaneous determination of praziquantel, pyrantel embonate, febantel and its active metabolites, oxfendazole and fenbendazole, in dog plasma by liquid chromatography/mass spectrometry.
[So] Source:Biomed Chromatogr;29(12):1859-65, 2015 Dec.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A liquid chromatography-electrospray-mass spectrometry method (LC/MS) has been developed and validated for determination of praziquantel (PZQ), pyrantel (PYR), febantel (FBT), and the active metabolites fenbendazole (FEN) and oxfendazole (OXF), in dog plasma, using mebendazole as internal standard (IS). The method consists of solid-phase extractions on Strata-X polymeric cartridges. Chromatographic separation was carried out on a Phenomenex Gemini C6 -Phenyl column using binary gradient elution containing methanol and 50 mm ammonium-formate (pH 3). The method was linear (r(2) ≥ 0.990) over concentration ranges of 3-250 ng/mL for PYR andFEB, 5-250 ng/mL for OXF and FEN, and 24-1000 ng/mL for PZQ. The mean precisions were 1.3-10.6% (within-run) and 2.5-9.1% (between-run), and mean accuracies were 90.7-109.4% (within-run) and 91.6-108.2% (between-run). The relative standard deviations (RSD) were <9.1%. The mean recoveries of five targeted compounds from dog plasma ranged from 77 to 94%.The new LC/MS method described herein was fully validated and successfully applied to the bioequivalence studies of different anthelmintic formulations such as tablets containing PZQ, PYR embonate and FBT in dogs after oral administration.
[Mh] Termos MeSH primário: Benzimidazóis/sangue
Cromatografia Líquida/métodos
Fenbendazol/sangue
Guanidinas/sangue
Espectrometria de Massas/métodos
Praziquantel/sangue
Pamoato de Pirantel/sangue
[Mh] Termos MeSH secundário: Animais
Benzimidazóis/química
Benzimidazóis/farmacocinética
Cães
Feminino
Fenbendazol/química
Fenbendazol/farmacocinética
Guanidinas/química
Guanidinas/farmacocinética
Limite de Detecção
Modelos Lineares
Masculino
Praziquantel/química
Praziquantel/farmacocinética
Pamoato de Pirantel/química
Pamoato de Pirantel/farmacocinética
Reprodutibilidade dos Testes
Extração em Fase Sólida
Equivalência Terapêutica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzimidazoles); 0 (Guanidines); 621BVT9M36 (Fenbendazole); 6490C9U457 (Praziquantel); 81BK194Z5M (Pyrantel Pamoate); OMP2H17F9E (oxfendazole); S75C401OS1 (febantel)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:151027
[Lr] Data última revisão:
151027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150625
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3507


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[PMID]:25889461
[Au] Autor:Meekums H; Hawash MB; Sparks AM; Oviedo Y; Sandoval C; Chico ME; Stothard JR; Cooper PJ; Nejsum P; Betson M
[Ad] Endereço:Department of Production and Population Health, Royal Veterinary College, Hawkshead Lane, Hatfield, Herts, AL9 7TA, UK. hayley.meekums@hotmail.co.uk.
[Ti] Título:A genetic analysis of Trichuris trichiura and Trichuris suis from Ecuador.
[So] Source:Parasit Vectors;8:168, 2015 Mar 19.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Since the nematodes Trichuris trichiura and T. suis are morphologically indistinguishable, genetic analysis is required to assess epidemiological cross-over between people and pigs. This study aimed to clarify the transmission biology of trichuriasis in Ecuador. FINDINGS: Adult Trichuris worms were collected during a parasitological survey of 132 people and 46 pigs in Esmeraldas Province, Ecuador. Morphometric analysis of 49 pig worms and 64 human worms revealed significant variation. In discriminant analysis morphometric characteristics correctly classified male worms according to host species. In PCR-RFLP analysis of the ribosomal Internal Transcribed Spacer (ITS-2) and 18S DNA (59 pig worms and 82 human worms), nearly all Trichuris exhibited expected restriction patterns. However, two pig-derived worms showed a "heterozygous-type" ITS-2 pattern, with one also having a "heterozygous-type" 18S pattern. Phylogenetic analysis of the mitochondrial large ribosomal subunit partitioned worms by host species. Notably, some Ecuadorian T. suis clustered with porcine Trichuris from USA and Denmark and some with Chinese T. suis. CONCLUSION: This is the first study in Latin America to genetically analyse Trichuris parasites. Although T. trichiura does not appear to be zoonotic in Ecuador, there is evidence of genetic exchange between T. trichiura and T. suis warranting more detailed genetic sampling.
[Mh] Termos MeSH primário: Tricuríase/veterinária
Trichuris/genética
Zoonoses
[Mh] Termos MeSH secundário: Albendazol/uso terapêutico
Animais
Anti-Helmínticos/uso terapêutico
Equador/epidemiologia
Seres Humanos
Filogenia
Pamoato de Pirantel/uso terapêutico
População Rural
Tricuríase/epidemiologia
Tricuríase/parasitologia
Tricuríase/transmissão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 81BK194Z5M (Pyrantel Pamoate); F4216019LN (Albendazole)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150419
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-015-0782-9



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