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[PMID]:24929448
[Au] Autor:Reinemeyer CR; Prado JC; Andersen UV; Nielsen MK; Schricker B; Kennedy T
[Ad] Endereço:East Tennessee Clinical Research, Rockwood, TN, USA. Electronic address: crr@easttenncr.com.
[Ti] Título:Effects of daily pyrantel tartrate on strongylid population dynamics and performance parameters of young horses repeatedly infected with cyathostomins and Strongylus vulgaris.
[So] Source:Vet Parasitol;204(3-4):229-37, 2014 Aug 29.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Strongylid infections are ubiquitous in grazing horse populations. Infections with cyathostomin (small strongyle) and strongylin (large strongyle) nematodes have long been associated with clinical disease in horses, but little is known about their subclinical impact. A masked, randomized, controlled study was conducted to evaluate the effects of daily administration of pyrantel tartrate on body condition scores, weight gain, fecal egg counts, and total worm counts of young horses repeatedly inoculated with strongylid larvae. Twenty eight immature horses were treated with larvicidal anthelmintic regimens and randomly allocated to two groups. Group 1 horses were given a pelleted placebo product once daily, and those in Group 2 received pyrantel tartrate once daily at ∼ 2.64 mg/kg body weight. On five days during each week, ∼ 5000 infective cyathostomin larvae were administered to each horse. In addition, horses received ∼ 25 infective Strongylus vulgaris larvae once weekly. Horses were maintained on pasture for 154 days and had ad libitum access to grass hay throughout. At approximate, 14-day intervals, body weights were measured, body condition scores were assigned, fecal samples were collected for egg counts, and blood samples were collected for measurement of S. vulgaris antibodies and various physiologic parameters. After 22 weeks at pasture and 14-17 days in confinement, horses were euthanatized and necropsied. Nematodes were recovered and counted from aliquots of organ contents, representative samples of large intestinal mucosa, and the root of the cranial mesenteric artery. Daily treatment with pyrantel tartrate at the recommended dosage significantly reduced numbers of adult cyathostomins in the gut lumen and early third-stage larvae in the cecal mucosa, increased the proportions of fourth-stage larvae in the gut contents, and was accompanied by significant improvements in body condition scores. Fecal egg counts of horses receiving daily pyrantel tartrate were significantly reduced, with percentages of efficacy ranging from 84.4% to 98.9%, but egg counts of both groups increased significantly over the course of the study. Treatment also significantly reduced the numbers of S. vulgaris larvae in the cranial mesenteric artery by 99.2%. Serum antibodies to S. vulgaris apparently persisted from pre-enrollment infections, but ELISA values gradually declined over the course of the study. This study has provided useful insights into the effects of daily pyrantel tartrate on the dynamics of cyathostomin infection, and into some subclinical effects of strongylid parasitism in horses.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Doenças dos Cavalos/tratamento farmacológico
Tartarato de Pirantel/uso terapêutico
Infecções Equinas por Strongyloidea/tratamento farmacológico
Strongylus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ensaio de Imunoadsorção Enzimática/veterinária
Fezes/parasitologia
Feminino
Cavalos
Intestino Grosso/parasitologia
Larva
Masculino
Dinâmica Populacional
Infecções Equinas por Strongyloidea/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140616
[St] Status:MEDLINE


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[PMID]:22844700
[Au] Autor:Barski D; Spodniewska A
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-719 Olsztyn, Poland. darbar@uwm.edu.pl
[Ti] Título:Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate.
[So] Source:Pol J Vet Sci;15(2):239-45, 2012.
[Is] ISSN:1505-1773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:This study presents the results of research concerning the effect of single and combined application of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes. Pyrantel tartrate was applied twice, at a dose of 85 mg/kg bw at a two week interval, i.e. on day 14 and 28 of the experiment, orally, in a water solution with a stomach tube. Dimethoate was administered with drinking water for 28 days at a dose of 25 mg/kg bw/day. It was found that pyrantel tartrate caused only small changes in the activity of the antioxidative enzymes under analysis. Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress. In combined intoxication, no significant effects of administering pyrantel tartrate on the activity of CAT, SOD and GPx was found in animals poisoned with dimethoate. The profile of changes was similar to that observed in rats exposed only to the organophosphorus insecticide. This may indicate a lack of interaction between the compounds used in the experiment.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Antioxidantes/metabolismo
Inibidores da Colinesterase/farmacologia
Dimetoato/toxicidade
Tartarato de Pirantel/toxicidade
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/administração & dosagem
Catalase/metabolismo
Inibidores da Colinesterase/administração & dosagem
Dimetoato/administração & dosagem
Quimioterapia Combinada
Eritrócitos/efeitos dos fármacos
Eritrócitos/enzimologia
Glutationa Peroxidase/metabolismo
Masculino
Tartarato de Pirantel/administração & dosagem
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Antioxidants); 0 (Cholinesterase Inhibitors); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); SC82VF0480 (Pyrantel Tartrate); W6U08B045O (Dimethoate)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120801
[St] Status:MEDLINE


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[PMID]:19382559
[Au] Autor:Sabbatini JZ
[Ad] Endereço:Covance Laboratories, 3301 Kinsman Blvd, Madison, WI 53704, USA. Jane.Sabbatini@covance.com
[Ti] Título:Progress on the development and single-laboratory validation of a high-performance liquid chromatographic method for the determination of carbadox and pyrantel tartrate in type B and C medicated feeds.
[So] Source:J AOAC Int;92(1):26-33, 2009 Jan-Feb.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Carbadox, an antimicrobial agent, and pyrantel tartrate, an anthelmintic, are feed additives that are often used in combination in the United States. The current AOAC methods for these analytes are spectrophotometric, using standard addition techniques. These methods are labor-intensive and prone to variability as well as matrix interferences. Published methods for both analytes that use high-performance liquid chromatography were evaluated and a test method was developed. The method uses a water prewetting step to enhance extraction of pyrantel followed by extraction with acetonitrile-ethanol (50 + 50). Sample extracts are filtered through a glass fiber filter and purified using alumina solid-phase extraction columns. Chromatography is performed on a C18 column with a gradient mobile phase of dibutylamine acetate and acetonitrile. The data show that both analytes exhibit acceptable peak shape when a C18 column that is both acid- and base-deactivated is used. Linearity has been established and initial recovery studies on medicated swine feeds are promising.
[Mh] Termos MeSH primário: Ração Animal/análise
Carbadox/análise
Suplementos Nutricionais/análise
Preparações Farmacêuticas/análise
Tartarato de Pirantel/análise
[Mh] Termos MeSH secundário: Anti-Helmínticos/análise
Anti-Infecciosos/análise
Carcinógenos/análise
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia Líquida/métodos
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Anti-Infective Agents); 0 (Carcinogens); 0 (Pharmaceutical Preparations); M2X04R2E2Y (Carbadox); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0906
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090423
[St] Status:MEDLINE


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[PMID]:17013652
[Au] Autor:Lyons ET; Tolliver SC; Rathgeber RA; Collins SS
[Ad] Endereço:Department of Veterinary Science, University of Kentucky, Gluck Equine Research Center, Lexington, KY 40546-0099, USA. elyons1@uky.edu
[Ti] Título:Parasite field study in central Kentucky on thoroughbred foals (born in 2004) treated with pyrantel tartrate daily and other parasiticides periodically.
[So] Source:Parasitol Res;100(3):473-8, 2007 Feb.
[Is] ISSN:0932-0113
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Foals (79), born in 2004 on three thoroughbred horse farms (C, M, and S) in central Kentucky, were fed pyrantel tartrate daily, beginning at about 3 months of age. In addition, other parasiticides [fenbendazole (FBZ), ivermectin (IVM) alone or with praziquantel (PRAZ), oxibendazole (OBZ), pyrantel pamoate (PRT), and moxidectin (MOX)] were given periodically. All treatments were administered by farm personnel. Over a 14-month period, from May 2004 to July 2005, collections (n=989) of feces were made from the foals for determination of presence of internal parasite eggs/oocysts by qualitative and/or quantitative methods. Conclusions on drug activity are based necessarily on considering the combined effect of pyrantel tartrate and the other compounds. For small strongyles, this was related to which specific additional compound was given. Based on the percentage of foals with strongyle-egg-positive feces and/or the level of eggs per gram of feces (EPG) counts for the foals after treatment, drug activity on small strongyles was highest to lowest for MOX, IVM and IVM/PRAZ, FBZ, OBZ, PRT, and FBZ (2x for 5 days). The macrocyclic lactones (MOX and IVM) were highly superior to the other compounds. Some of the strongyle counts were high (over 2,000), especially on one farm (S), during periods when foals received only pyrantel tartrate, but a few days after administration of therapeutic dose rates of the drugs IVM or MOX, they were negative or very low. Ascarid eggs were present in feces of three foals after treatment with a combination of IVM and PRAZ. The qualitative method was more efficient than the quantitative method in detection of ascarid and strongyle eggs in the feces. Prevalence of eggs of ascarids (Parascaris equorum) was low (0, 4, and 31%), of strongyles high (80, 100, and 100%), of Strongyloides westeri very low (only one infected foal), and oocysts of Eimeria leuckarti medium to high (36, 41, and 85%) for the three farms, C, M, and S, respectively. It is uncertain whether the low ascarid prevalence was from activity of pyrantel tartrate and/or the other drugs or to a limited source of infective eggs.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Helmintíase Animal/tratamento farmacológico
Doenças dos Cavalos/prevenção & controle
Doenças dos Cavalos/parasitologia
Cavalos/parasitologia
Tartarato de Pirantel/administração & dosagem
Tartarato de Pirantel/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Helmínticos/administração & dosagem
Feminino
Helmintíase Animal/epidemiologia
Helmintíase Animal/parasitologia
Doenças dos Cavalos/epidemiologia
Kentucky/epidemiologia
Masculino
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0709
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061003
[St] Status:MEDLINE


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[PMID]:16682123
[Au] Autor:Slocombe JO; de Gannes RV
[Ad] Endereço:Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ont., Canada. oslocomb@uoguelph.ca
[Ti] Título:Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin.
[So] Source:Vet Parasitol;140(1-2):181-4, 2006 Aug 31.
[Is] ISSN:0304-4017
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Clinical trials using fecal egg count reduction tests and coproculture were conducted with yearlings and mares on a farm in 1997. Fecal samples were taken from each horse to estimate the number of strongyle eggs/g feces with Cornell-Wisconsin centrifugal flotation and Cornell-McMaster dilution techniques. Eleven of 15 yearlings, which had been on a daily feeding of grain with pyrantel tartrate for 66 d were found with strongyle eggs in feces. This was the first time the in-feed medication had been used on the farm. Nine yearlings were randomised into three groups; continuation of daily pyrantel tartrate or one treatment with pyrantel pamoate or moxidectin. Two of three yearlings given pyrantel tartrate or pamoate had no reduction in the eggs/g feces. These six yearlings were then given moxidectin and in all yearlings the eggs/g feces was reduced to zero. The 66 d of pyrantel tartrate use was an inadequate time for development of resistant cyathostomes and a hypothesis was the resistance was due to extensive use on the farm over many years of pyrantel pamoate at twice the label dose for control of tapeworms. That hypothesis was tested with 12 mares with strongyle eggs in the feces randomised into two treatment groups: pyrantel pamoate at label dose or moxidectin. Five of six mares given pyrantel had <80% reduction in egg/g feces. These mares were then given moxidectin and in all mares the eggs/g feces was reduced to zero. Only cyathostomes were found on culture and apparently there was side resistance among the pyrantel salts.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Resistência a Medicamentos
Fezes/parasitologia
Doenças dos Cavalos/tratamento farmacológico
Infecções por Strongylida/veterinária
Strongyloidea/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Canadá
Feminino
Cavalos
Macrolídeos/uso terapêutico
Contagem de Ovos de Parasitas/veterinária
Testes de Sensibilidade Parasitária
Tartarato de Pirantel/uso terapêutico
Distribuição Aleatória
Infecções por Strongylida/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Macrolides); 51570-36-6 (milbemycin); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0610
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060510
[St] Status:MEDLINE


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[PMID]:16426178
[Au] Autor:Brazik EL; Luquire JT; Little D
[Ad] Endereço:Carolina Coastal Equine Veterinary Service, 1286 Hwy 117 N, Burgaw, NC 28425, USA.
[Ti] Título:Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate.
[So] Source:J Am Vet Med Assoc;228(1):101-3, 2006 Jan 01.
[Is] ISSN:0003-1488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CASE DESCRIPTIONS: 16 horses treated daily with pyrantel tartrate (2.64 mg/kg [1.2 mg/lb], PO) as part of a prophylactic anthelmintic program. CLINICAL FINDINGS: Fecal worm egg counts (FWECs) were obtained on all 16 horses. Mean FWEC was 478 eggs/g (epg; range, 0 to 4,075 epg). Three of the 16 horses were responsible for 85% of the total fecal egg output for the herd on the day of sampling. Six horses had FWECs < 200 epg. Three horses that had arrived within 4 months of the sampling date had FWECs < 100 epg. TREATMENT AND OUTCOME: An FWEC reduction test was initiated the day after FWECs were obtained; all horses with FWECs > 100 epg (9 horses) were treated with pyrantel pamoate (6.6 mg/kg [3 mg/lb], PO), and 14 days later, the FWEC was repeated. During the 14-day period, all horses received pyrantel tartrate (2.64 mg/kg, PO) daily. Fecal worm egg count reduction was calculated for each horse. Mean FWEC reduction for the group was 28.5% (range, increase of 21% in FWECs 14 days after treatment to a decrease of 100% in FWEC 14 days after treatment). CLINICAL RELEVANCE: Farms should be monitored for cyathostomes resistant to pyrantel pamoate prior to use of pyrantel tartrate. Fecal worm egg counts should be monitored routinely in horses before and after treatment to ensure efficacy of cyathostome control measures.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Doenças dos Cavalos/tratamento farmacológico
Pamoato de Pirantel/uso terapêutico
Tartarato de Pirantel/uso terapêutico
[Mh] Termos MeSH secundário: Administração Oral
Animais
Anti-Helmínticos/administração & dosagem
Resistência a Medicamentos
Fezes/parasitologia
Feminino
Cavalos
Masculino
Contagem de Ovos de Parasitas/veterinária
Testes de Sensibilidade Parasitária/veterinária
Pamoato de Pirantel/administração & dosagem
Tartarato de Pirantel/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 81BK194Z5M (Pyrantel Pamoate); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0604
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060124
[St] Status:MEDLINE


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[PMID]:15934612
[Au] Autor:Rossano MG; Schott HC; Kaneene JB; Murphy AJ; Kruttlin EA; Hines MT; Sellon DC; Patterson JS; Elsheikha HM; Dubey JP; Mansfield LS
[Ad] Endereço:Population Medicine Center, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:Effect of daily administration of pyrantel tartrate in preventing infection in horses experimentally challenged with Sarcocystis neurona.
[So] Source:Am J Vet Res;66(5):846-52, 2005 May.
[Is] ISSN:0002-9645
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether daily administration of pyrantel tartrate can prevent infection in horses experimentally challenged with Sarcocystis neurona. ANIMALS: 24 mixed-breed specific-pathogen-free weanling horses, 10 adult horses, 1 opossum, and 6 mice. PROCEDURE: Sarcocystis neurona-naïve weanling horses were randomly allocated to 2 groups. Group A received pyrantel tartrate at the labeled dose, and group B received a nonmedicated pellet. Both groups were orally inoculated with 100 sporocysts/d for 28 days, 500 sporocysts/d for 28 days, and 1000 sporocysts/d for 56 days. Blood samples were collected weekly, and CSF was collected monthly. Ten seronegative adult horses were monitored as untreated, uninfected control animals. All serum and CSF samples were tested by use of western blot tests to detect antibodies against S. neurona. At the end of the study, the number of seropositive and CSF-positive horses in groups A and B were compared by use of the Fisher exact test. Time to seroconversion on the basis of treatment groups and sex of horses was compared in 2 univariable Cox proportional hazards models. RESULTS: After 134 days of sporocyst inoculation, no significant differences were found between groups A and B for results of western blot tests of serum or CSF There were no significant differences in number of days to seroconversion on the basis of treatment groups or sex of horses. The control horses remained seronegative. CONCLUSIONS AND CLINICAL RELEVANCE: Daily administration of pyrantel tartrate at the current labeled dose does not prevent S. neurona infection in horses.
[Mh] Termos MeSH primário: Coccidiostáticos/uso terapêutico
Doenças dos Cavalos/prevenção & controle
Tartarato de Pirantel/uso terapêutico
Sarcocistose/veterinária
[Mh] Termos MeSH secundário: Animais
Feminino
Doenças dos Cavalos/parasitologia
Cavalos
Masculino
Sarcocistose/prevenção & controle
Fatores Sexuais
Fatores de Tempo
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coccidiostats); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0507
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050607
[St] Status:MEDLINE


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[PMID]:14632387
[Au] Autor:Konrardy JA; Burner MA; Garner TW; Litchman MA; Webster GK
[Ad] Endereço:Pfizer Global Manufacturing, Quality Operations, One Pfizer Way, Lee's Summit, MO 64081, USA.
[Ti] Título:Liquid chromatographic determination of pyrantel tartrate in medicated formulations.
[So] Source:J AOAC Int;86(5):882-7, 2003 Sep-Oct.
[Is] ISSN:1060-3271
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The validation of a novel liquid chromatographic (LC) method for the determination of pyrantel tartrate in feed is presented. The method provides a significant improvement over the efficiency and precision of AOAC Official Method 978.30. The method was shown to be accurate, precise, linear, and robust for medicated articles. Unlike the official method, the LC method was shown to be a superior stability-indicating method. After the method was validated by using laboratory blends, the effectiveness of the method was demonstrated with marketed product as well.
[Mh] Termos MeSH primário: Ração Animal/análise
Anti-Helmínticos/análise
Cromatografia Líquida/métodos
Tartarato de Pirantel/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida/economia
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0402
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031125
[St] Status:MEDLINE


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[PMID]:19746670
[Au] Autor:Kruttlin EA; Rossano MG; Murphy AJ; Vrable RA; Kaneene JB; Schott HC; Mansfield LS
[Ad] Endereço:Department of Large Animal Clinical Sciences, D201 Veterinary Medicine Center, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:The effects of pyrantel tartrate on Sarcocystis neurona merozoite viability.
[So] Source:Vet Ther;2(3):268-76, 2001.
[Is] ISSN:1528-3593
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sarcocystis neurona is the etiologic agent of equine protozoal myeloencephalitis, a neurologic disease of horses. The present study was designed to test the hypothesis that pyrantel tartrate can kill S. neurona merozoites growing in equine dermal cell culture. Sarcocystis neurona merozoites were exposed to a range of concentrations of pyrantel tartrate or sodium tartrate ranging from 0.001 to 0.01 M. Merozoites were then placed onto equine dermal cell cultures and incubated for 2 weeks to check for viability. At 1 and 2 weeks after inoculation, plaque counts were compared between treatments and, between treatments and controls. Merozoites exposed to concentrations of pyrantel tartrate higher than 0.0025 M (8.91 x 10(-4) g/ml) did not produce plaques in equine dermal cells, whereas those exposed to similar concentrations of the tartrate salt or medium alone produced significant numbers of plaques. These results demonstrate that pyrantel tartrate has activity against S. neurona merozoites in vitro and suggest that it may have activity against the sporozoite stage of the parasite found in the equine gut.
[Mh] Termos MeSH primário: Antiprotozoários/farmacologia
Merozoítos/efeitos dos fármacos
Tartarato de Pirantel/farmacologia
Sarcocystis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Relação Dose-Resposta a Droga
Cavalos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiprotozoal Agents); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090915
[St] Status:MEDLINE


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[PMID]:11358629
[Au] Autor:Lindsay DS; Dubey JP
[Ad] Endereço:Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 1410 Prices Fork Road, Blacksburg, VA 24061-0342, USA. lindsayd@vt.edu
[Ti] Título:Determination of the activity of pyrantel tartrate against Sarcocystis neurona in gamma-interferon gene knockout mice.
[So] Source:Vet Parasitol;97(2):141-4, 2001 May 22.
[Is] ISSN:0304-4017
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Equine protozoal myeloencephalitis (EPM) is the most important protozoal disease of horses in the United States. Some horse owners and equine clinicians believe that horses which are on daily pyrantel tartrate at 2.64mg/kg for helminth prophylaxis are less likely to develop EPM. The present study examined the efficacy of pyrantel tartrate in preventing clinical disease in gamma-interferon gene knockout (BALB/c-Ifng(tm1ts)) mice. No activity was seen against sporocyst-induced Sarcocystis neurona infections in mice treated prophylacticly with 4-5mg pyrantel tartrate per mouse per day in the drinking water.
[Mh] Termos MeSH primário: Antinematódeos/uso terapêutico
Interferon gama/fisiologia
Tartarato de Pirantel/uso terapêutico
Sarcocystis/efeitos dos fármacos
Sarcocistose/veterinária
[Mh] Termos MeSH secundário: Animais
Encéfalo/parasitologia
Modelos Animais de Doenças
Interferon gama/genética
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Sarcocistose/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antinematodal Agents); 82115-62-6 (Interferon-gamma); SC82VF0480 (Pyrantel Tartrate)
[Em] Mês de entrada:0110
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010519
[St] Status:MEDLINE



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