Base de dados : MEDLINE
Pesquisa : D03.066 [Categoria DeCS]
Referências encontradas : 53 [refinar]
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[PMID]:27413754
[Au] Autor:Ansarullah; Free C; Christopherson J; Chen Q; Gao J; Liu C; Naji A; Rabinovitch A; Guo Z
[Ad] Endereço:The Sanford Project, Children Health Research Center, Sanford Research, Sioux Falls, SD 57104, USA.
[Ti] Título:Activation of GPR119 Stimulates Human ß-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets.
[So] Source:J Diabetes Res;2016:1620821, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human ß-cell regeneration in vivo. Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) induced diabetes. The recipient mice were treated with PSN632408 or vehicle and BrdU daily. Human islet graft function in the mice was evaluated by nonfasting glucose levels, oral glucose tolerance, and removal of the grafts. Immunostaining for insulin, glucagon, and BrdU or Ki67 was performed in islet grafts to evaluate α- and ß-cell replication. Insulin and CK19 immunostaining was performed to evaluate ß-cell neogenesis. Four weeks after human islet transplantation, 71% of PSN632408-treated mice achieved normoglycaemia compared with 24% of vehicle-treated mice. Also, oral glucose tolerance was significantly improved in the PSN632408-treated mice. PSN632408 treatment significantly increased both human α- and ß-cell areas in islet grafts and stimulated α- and ß-cell replication. In addition, ß-cell neogenesis was induced from pancreatic duct cells in the islet grafts. Our results demonstrated that activation of GPR119 increases ß-cell mass by stimulating human ß-cell replication and neogenesis. Therefore, GPR119 activators may qualify as therapeutic agents to increase human ß-cell mass in patients with diabetes.
[Mh] Termos MeSH primário: Proliferação Celular/fisiologia
Diabetes Mellitus Experimental/metabolismo
Células Secretoras de Insulina/metabolismo
Ilhotas Pancreáticas/metabolismo
Receptores Acoplados a Proteínas-G/metabolismo
Regeneração/fisiologia
[Mh] Termos MeSH secundário: Ácidos Heterocíclicos/farmacologia
Animais
Proliferação Celular/efeitos dos fármacos
Glucagon/metabolismo
Insulina/metabolismo
Células Secretoras de Insulina/citologia
Células Secretoras de Insulina/efeitos dos fármacos
Ilhotas Pancreáticas/citologia
Ilhotas Pancreáticas/efeitos dos fármacos
Camundongos
Oxidiazóis/farmacologia
Receptores Acoplados a Proteínas-G/agonistas
Regeneração/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (GPR119 protein, human); 0 (Insulin); 0 (Oxadiazoles); 0 (PSN 632408); 0 (Receptors, G-Protein-Coupled); 9007-92-5 (Glucagon)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170531
[Lr] Data última revisão:
170531
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160715
[St] Status:MEDLINE
[do] DOI:10.1155/2016/1620821


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[PMID]:27110751
[Au] Autor:Shi YH; Dai DF; Li J; Dong YW; Jiang Y; Li HG; Gao Y; Chong CK; Li HY; Chu XQ; Yang C; Zhang Q; Tong ZS; Bai CG; Chen Y
[Ad] Endereço:Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, and Key Laboratory of Cancer Prevention and Therapy, Tianj
[Ti] Título:Sulforaphane Analogues with Heterocyclic Moieties: Syntheses and Inhibitory Activities against Cancer Cell Lines.
[So] Source:Molecules;21(4):514, 2016 Apr 21.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Recent studies have shown that sulforaphane (SFN) selectively inhibits the growth of ALDH⁺ breast cancer stem-like cells.Herein, a series of SFN analogues were synthesized and evaluated against breast cancer cell lines MCF-7 and SUM-159, and the leukemia stem cell-like cell line KG-1a. These SFN analogues were characterized by the replacement of the methyl group with heterocyclic moieties, and the replacement of the sulfoxide group with sulfide or sulfone. A growth inhibitory assay indicated that the tetrazole analogs 3d, 8d and 9d were significantly more potent than SFN against the three cancer cell lines. Compound 14c, the water soluble derivative of tetrazole sulfide 3d, demonstrated higher potency against KG-1a cell line than 3d. SFN, 3d and 14c significantly induced the activation of caspase-3, and reduced the ALDH⁺ subpopulation in the SUM159 cell line, while the marketed drug doxrubicin(DOX) increased the ALDH⁺ subpopulation.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/síntese química
Ácidos Heterocíclicos/farmacologia
Anticarcinógenos/síntese química
Anticarcinógenos/farmacologia
[Mh] Termos MeSH secundário: Ácidos Heterocíclicos/química
Aldeído Desidrogenase/metabolismo
Anticarcinógenos/química
Caspase 3/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Isotiocianatos/química
Células MCF-7
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Anticarcinogenic Agents); 0 (Isothiocyanates); EC 1.2.1.3 (Aldehyde Dehydrogenase); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (Caspase 3); GA49J4310U (sulforafan)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE


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[PMID]:26840282
[Au] Autor:Suresh Kumar R; Almansour AI; Arumugam N; Altaf M; Menéndez JC; Kumar RR; Osman H
[Ad] Endereço:Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. rajusures@gmail.com.
[Ti] Título:A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid.
[So] Source:Molecules;21(2):165, 2016 Jan 29.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The microwave-assisted three-component reactions of 3,5-bis(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones, acenaphthenequinone and cyclic α-amino acids in an ionic liquid, 1-butyl-3-methylimidazolium bromide, occurred through a domino sequence affording structurally intriguing diazaheptacyclic cage-like compounds in excellent yields.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/síntese química
Líquidos Iônicos/química
[Mh] Termos MeSH secundário: Acenaftenos/química
Ácidos Heterocíclicos/química
Catálise
Imidazóis/química
Micro-Ondas
Estrutura Molecular
Piridonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acenaphthenes); 0 (Acids, Heterocyclic); 0 (Imidazoles); 0 (Ionic Liquids); 0 (Pyridones); 3950D6UEIQ (acenaphthenequinone); 41PS77334A (1-butyl-3-methylimidazolium chloride)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160204
[St] Status:MEDLINE


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[PMID]:26642657
[Au] Autor:Strupinska M; Rostafinska-Suchar G; Pirianowicz-Chaber E; Grabczuk M; Józwenko M; Kowalczyk H; Szuba J; Wójcicka M; Chen T; Mazurek AP
[Ti] Título:SYNTHESIS AND STUDY OF HALOGENATED BENZYLAMIDES OF SOME ISOCYCLIC AND HETEROCYCLIC ACIDS AS POTENTIAL ANTICONVULSANTS.
[So] Source:Acta Pol Pharm;72(3):489-96, 2015 May-Jun.
[Is] ISSN:0001-6837
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:A series of potential anticonvulsants have been synthesized. There are eight fluorobenzylamides and three chlorobenzylamides of isocyclic or heterocyclic acids. Two not halogenated benzylamides were also synthesized to compare the effect of halogenation. The aim of the research performed was to evaluate whether halogenation of the mother structure is able to improve its anticonvulsant activity. The compounds were tested in Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH. Compound 1 showed MES ED50 = 80.32 mg/kg, PI = 3.16. Compound 7 showed CKM ED50 = 56.72 mg/kg. Compound 8 showed MES ED50 = 34.23 mg/kg and scPTZ ED50 > 300 mg/kg, PI = 8.53.Compound 13 showed 6Hz ED50 = 78.96, PI = 3.37. The results indicate that fluorination does not improve activity, whereas chlorination in our experiment even reduces it.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/síntese química
Amidas/síntese química
Anticonvulsivantes/síntese química
Compostos de Benzil/síntese química
[Mh] Termos MeSH secundário: Ácidos Heterocíclicos/farmacologia
Amidas/farmacologia
Animais
Anticonvulsivantes/farmacologia
Compostos de Benzil/farmacologia
Camundongos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Amides); 0 (Anticonvulsants); 0 (Benzyl Compounds)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151208
[Lr] Data última revisão:
151208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151209
[St] Status:MEDLINE


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[PMID]:26445401
[Au] Autor:Gibis M; Weiss J
[Ad] Endereço:Dept. of Food Physics and Meat Science, Inst. of Food Science and Biotechnology, Univ. of Hohenheim, Garbenstrasse 21/25, 70599, Stuttgart, Germany.
[Ti] Título:Impact of Precursors Creatine, Creatinine, and Glucose on the Formation of Heterocyclic Aromatic Amines in Grilled Patties of Various Animal Species.
[So] Source:J Food Sci;80(11):C2430-9, 2015 Nov.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The impact of precursors such as creatine, creatinine, and glucose on the formation of mutagenic/carcinogenic heterocyclic amines (HAs) were studied in patties of 9 different animal species equally heat treated with a double-plate contact grill. All grilled patties of the various species (veal, beef, pork, lamb, horse, venison, turkey, chicken, ostrich) contained several HAs such as MeIQx (2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline; 0.5-1.4 ng/g), 4,8-DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f] quinoxaline, 0 to 1.3 ng/g), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine, 1.2 to 10.5 ng/g), harman (1-methyl-9H-pyrido[3,4-b] indole; 0.5 to 3.2 ng/g), and/or norharman (9H-pyrido[3,4-b]indole 0.5 to 1.9 ng/g). Residual glycogen (glucose) content varied greatly from 0.07 to 1.46 wt% on a dry matter (DM) basis. Total creatin(in)e content in raw meat (1.36 to 2.0 wt% DM) hardly differed between species, except in turkey and ostrich (1.1 wt% DM). Chicken contained, compared to all other species, very low concentrations of glucose (0.07 wt% DM) and the highest levels of nonprotein nitrogen compounds. The free amino acids lysine (r = 0.77, P < 0.001), tyrosine, phenylalanine, proline, isoleucine, and aspartic acid (r = 0.47-0.56, P < 0.05) showed significant correlation to PhIP in chicken. Also a linear correlation was found to exist between PhIP (r = 0.87, P < 0.001) and MeIQx (r = 0.35, P < 0.01), and the molar ratio of creatin(in)e to glucose, respectively. Harman as co-mutagens was linearly correlated to the concentration of glucose (r = 0.65, P < 0.001). By contrast, norharman was not significant correlated to glucose levels.
[Mh] Termos MeSH primário: Aminas/análise
Culinária
Creatina/química
Creatinina/química
Glucose/química
Carne/análise
Mutagênicos/análise
[Mh] Termos MeSH secundário: Ácidos Heterocíclicos/análise
Aminoácidos
Animais
Bovinos
Cromatografia Líquida de Alta Pressão
Cavalos
Temperatura Alta
Seres Humanos
Imidazóis/análise
Aves Domésticas
Piridinas/análise
Quinoxalinas/análise
Ovinos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Amines); 0 (Amino Acids); 0 (Imidazoles); 0 (Mutagens); 0 (Pyridines); 0 (Quinoxalines); 77500-04-0 (2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline); 909C6UN66T (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine); AYI8EX34EU (Creatinine); IY9XDZ35W2 (Glucose); MU72812GK0 (Creatine); NH9L3PP67S (pyridine); YRA7G7WU6P (3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151109
[Lr] Data última revisão:
151109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151008
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13090


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[PMID]:26096538
[Au] Autor:Li PF; Schon TB; Seferos DS
[Ad] Endereço:Department of Chemistry, University of Toronto, 80 St. George, Toronto, ON M5S 3H6 (Canada) http://www.chem.utoronto.ca/wp/seferos/
[Ti] Título:Thiophene, Selenophene, and Tellurophene-based Three-Dimensional Organic Frameworks.
[So] Source:Angew Chem Int Ed Engl;54(32):9361-6, 2015 Aug 03.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:3D frameworks are important because of their potential to combine the advantageous properties of porous materials with those associated with polymers. A series of novel 3D aromatic frameworks are presented that incorporate the heterocycles thiophene, selenophene, and tellurophene. The specific surface area and pore width of frameworks depends on the element that is used to build the framework. Optoelectronic properties are element-dependent, with heavy atoms red-shifting the optical properties and decreasing the energy gap of the solid. The metalloid nature of tellurophene allows the properties of this material to be tuned based on its oxidation state, even as an insoluble solid. The incorporation of the optoelectronic active thiophene, selenophene, and tellurophene units and the effect that they have on properties was studied. A supercapcitor device was fabricated using these frameworks, showing that these 3D frameworks are promising for optoelectronic uses.
[Mh] Termos MeSH primário: Compostos Organometálicos/síntese química
Compostos Organosselênicos/síntese química
Polímeros/química
Telúrio/química
Tiofenos/química
[Mh] Termos MeSH secundário: Ácidos Heterocíclicos/química
Espectroscopia de Ressonância Magnética
Microscopia Eletrônica de Varredura
Compostos Organometálicos/química
Compostos Organosselênicos/química
Porosidade
Teoria Quântica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Organometallic Compounds); 0 (Organoselenium Compounds); 0 (Polymers); 0 (Thiophenes); NQA0O090ZJ (Tellurium)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:150729
[Lr] Data última revisão:
150729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201503418


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[PMID]:26015328
[Au] Autor:Poulsen PH; Feu KS; Paz BM; Jensen F; Jørgensen KA
[Ad] Endereço:Department of Chemistry, Aarhus University, 8000 Aarhus C (Denmark).
[Ti] Título:Organocatalytic Asymmetric 1,6-Addition/1,4-Addition Sequence to 2,4-Dienals for the Synthesis of Chiral Chromans.
[So] Source:Angew Chem Int Ed Engl;54(28):8203-7, 2015 Jul 06.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A novel asymmetric organocatalytic 1,6-addition/1,4-addition sequence to 2,4-dienals is described. Based on a 1,6-Friedel-Crafts/1,4-oxa-Michael cascade, the organocatalyst directs the reaction of hydroxyarenes with a vinylogous iminium-ion intermediate to give only one out of four possible regioisomers, thus providing optically active chromans in high yields and 94-99 % ee. Furthermore, several transformations are presented, including the formation of an optically active macrocyclic lactam. Finally, the mechanism for the novel reaction is discussed based on computational studies.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/química
Cromanos/química
[Mh] Termos MeSH secundário: Catálise
Cromanos/síntese química
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Chromans)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150701
[Lr] Data última revisão:
150701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150528
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201503370


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[PMID]:26013998
[Au] Autor:Li L; Zhou B; Wang YH; Shu C; Pan YF; Lu X; Ye LW
[Ad] Endereço:State Key Laboratory for Physical Chemistry of Solid Surfaces & The Key Laboratory for Chemical Biology of Fujian Province, Department of Chemistry, Xiamen University, Xiamen 361005 (China).
[Ti] Título:Zinc-Catalyzed Alkyne Oxidation/C-H Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and ß-Carbolines.
[So] Source:Angew Chem Int Ed Engl;54(28):8245-9, 2015 Jul 06.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:An efficient zinc(II)-catalyzed alkyne oxidation/C-H functionalization sequence was developed, thus leading to highly site-selective synthesis of a variety of isoquinolones and ß-carbolines. Importantly, in contrast to the well-established gold-catalyzed intermolecular alkyne oxidation, over-oxidation can be completely suppressed in this system and the reaction most likely proceeds by a Friedel-Crafts-type pathway. Mechanistic studies and theoretical calculations are described.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/química
Carbolinas/química
Óxidos de Nitrogênio/química
Zinco/química
[Mh] Termos MeSH secundário: Catálise
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic); 0 (Carbolines); 0 (Nitrogen Oxides); J41CSQ7QDS (Zinc)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150701
[Lr] Data última revisão:
150701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150528
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201502553


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[PMID]:26013957
[Au] Autor:Pavlakos I; Arif T; Aliev AE; Motherwell WB; Tizzard GJ; Coles SJ
[Ad] Endereço:Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ (UK).
[Ti] Título:Noncovalent Lone Pair⋅⋅⋅(No-π!)-Heteroarene Interactions: The Janus-Faced Hydroxy Group.
[So] Source:Angew Chem Int Ed Engl;54(28):8169-74, 2015 Jul 06.
[Is] ISSN:1521-3773
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A comparative study using NMR spectroscopy and designed top-pan molecular balances demonstrates that the noncovalent interaction of a hydroxy group with π-deficient pyrazine and quinoxaline units involves a lone pair-heteroarene interaction which is much stronger and solvent independent when measured relative to the classical π-facial hydrogen bond to a benzene ring. Alkyl fluorides also prefer the heteroarene rings over the benzene ring. The attractive interaction between a quinoxaline and a terminal alkyne is also stronger than the intramolecular hydrogen bond to an arene.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/química
Espectroscopia de Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Ligações de Hidrogênio
Modelos Moleculares
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acids, Heterocyclic)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150701
[Lr] Data última revisão:
150701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150528
[St] Status:MEDLINE
[do] DOI:10.1002/anie.201502103


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[PMID]:25736019
[Au] Autor:Huang YY; Yang X; Chen Z; Verpoort F; Shibata N
[Ad] Endereço:Department of Chemistry, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070 (P.R. China). huangyy@whut.edu.cn.
[Ti] Título:Catalytic asymmetric synthesis of enantioenriched heterocycles bearing a C-CF3 stereogenic center.
[So] Source:Chemistry;21(24):8664-84, 2015 Jun 08.
[Is] ISSN:1521-3765
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Given the important agricultural and medicinal application of optically pure heterocycles bearing a trifluoromethyl group at the stereogenic carbon center in the heterocyclic framework, the exploration of efficient and practical synthetic strategies to such types of molecules remains highly desirable. Catalytic enantioselective synthesis has one clear advantage that it is more cost-effective than other synthetic methods, but remains limited by challenges in achieving excellent yield and stereoselectivities with a low catalyst loading. Thus far, numerous models of organo- and organometal-catalyzed asymmetric reactions have been exploited to achieve this elusive goal over the past decade. This review article describes recent progress on this research topic, and focuses on an understanding of the catalytic asymmetric protocols exemplified in the catalytic enantioselective synthesis of a wide range of complex enantioenriched trifluoromethylated heterocycles.
[Mh] Termos MeSH primário: Ácidos Heterocíclicos/química
[Mh] Termos MeSH secundário: Catálise
Estrutura Molecular
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Acids, Heterocyclic)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150528
[Lr] Data última revisão:
150528
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150305
[St] Status:MEDLINE
[do] DOI:10.1002/chem.201500361



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