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Fotocópia
[PMID]:27913936
[Au] Autor:Yudin MA; Vengerovich NG; Sagalov GS; Vahvijanen MS; Bykov VN; Chepur SV
[Ad] Endereço:State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia.
[Ti] Título:Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine.
[So] Source:Bull Exp Biol Med;162(2):215-219, 2016 Dec.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances.
[Mh] Termos MeSH primário: Analgésicos não Entorpecentes/farmacologia
Analgésicos Opioides/farmacologia
Dexmedetomidina/farmacologia
Promedol/farmacologia
Respiração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais não Endogâmicos
Esquema de Medicação
Combinação de Medicamentos
Cálculos da Dosagem de Medicamento
Masculino
Ratos
Testes de Função Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 0 (Drug Combinations); 64-39-1 (Promedol); 67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170210
[Lr] Data última revisão:
170210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE


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Fotocópia
[PMID]:27249867
[Au] Autor:Smirnov VM; Sveshnikov DS; Lychkova AE; Maysnikov IL; Kuchuk AV; Ivanchenko LM; Samko YN
[Ti] Título:[SEROTONERGIC REGULATION OF THE DUODENUM CONTRACTIONS].
[So] Source:Eksp Klin Gastroenterol;(10):55-60, 2015.
[Is] ISSN:1682-8658
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The review contains an analysis of literature data on enhancement mechanisms of duodenum contractions arising during stimulation of the sympathetic trunk in the right thoracic cavity in dogs. It is established in experiments that There are mostly enhancement, not relaxation of the organ contraction occured. In this case the stimulatory effect due to the excitation of the parasympathetic fibers is excluded. The trimeperedin inhibit the serotonin receptors of autonomic ganglia neurons stimulatory activity during the nerve stimulation. It is concluded that the sympathetic trunk contain the preganglionic serotonergic nerve fibers, whose activation leads to increased bowel contractions. Direct adipinate-serotonin administration increased the bowel contraction that confirm the preganglionic serotonergic nerve fibers presence in the sympathetic trunk. The practical significance of these studies is that the new approach to the development of pharmacological agents to stimulate the motility of the gastrointestinal tract was found. The trimeperedin may inhibit the serotoninergic nerves activity that resulted in the perioperative constipation in surgical patients. Practical recommendation to exclude trimeperedin in preparing the patient for surgery to prevent perioperative constipation is formulated.
[Mh] Termos MeSH primário: Duodeno/inervação
Contração Muscular/fisiologia
Músculo Liso/inervação
Receptores de Serotonina/metabolismo
Neurônios Serotoninérgicos/metabolismo
Sistema Nervoso Simpático/fisiologia
[Mh] Termos MeSH secundário: Animais
Duodeno/fisiologia
Seres Humanos
Contração Muscular/efeitos dos fármacos
Músculo Liso/fisiologia
Promedol/farmacologia
Neurônios Serotoninérgicos/efeitos dos fármacos
Antagonistas da Serotonina/farmacologia
Sistema Nervoso Simpático/efeitos dos fármacos
Sistema Nervoso Simpático/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Receptors, Serotonin); 0 (Serotonin Antagonists); 64-39-1 (Promedol)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160602
[Lr] Data última revisão:
160602
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE


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Fotocópia
[PMID]:25842937
[Au] Autor:Levchenko OK; Shulutko EM; Gemdzhian ÉG; Gorodetskii VM
[Ti] Título:[Thrombocytopenia and postoperative analgesia].
[So] Source:Anesteziol Reanimatol;59(5):27-32, 2014 Sep-Oct.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:OBJECTIVE: To develop effective and safe measures of postoperative multimodal analgesia (optimizing the use of narcotic analgesics) in surgical treatment of hematological patients with thrombocytopenia. DESIGN: A pilot and prospective comparative controlled study. METHODS: We studied 27 patients with acquired thrombocytopenia who underwent laparoscopic splenectomy. Three schemes of anesthesia were used: 1) Nefopam 20 mg/day + trimeperidin (n = 7); 2) Paracetamol 4 g/day + trimeperidin (n = 10); 3) paracetamol + trimeperidin + glucocorticosteroids (GC) (through treatment of the underlying disease) (n = 10). Analgesic properties and effect of each scheme were assessed according to a rating scale of pain NRS (10 points) and VAS (100 points) studied. Additionally we evaluated the effect of nefopam and paracetamol on the functional properties of platelets and hemostasis, platelet levels while monitoring and indicators of thromboelastogram (TEG). RESULTS: Application of paracetamol + trimeperidin accompanied with effectively reducing of postoperative pain (less than 5 points on the NRS). The level of postoperative pain was lower in patients who were treated with corticosteroids within the therapy of the underlying disease before surgery and who continued to receive it in postoperative period (2-3 points NRS). Nefopam use in the perioperative period is not only inferior to the analgesic effect of paracetamol, but also causes frequent side effects. Consumption of narcotic analgesic--trimeperidin when applying nefopam averaged 43 mg/day, the appointment of paracetamol--28 mg/day, using a combination of paracetamol + GC--20 mg/day. Thus, GC within the underlying disease treatment substantially reduces the need for opioid analgesics. A monitoring of the number of platelets and TEG did not shows negative effect of paracetamol and nefopam on platelet and plasma hemostasis. CONCLUSIONS: Nefopam and paracetamol may be used in patients with thrombocytopenia, as do not affect the hemostasis and platelet count. Application of postoperative analgesia scheme paracetamol + trimeperidin in patients receiving corticosteroids provides the maximum reduction of pain with the least consumption of narcotic analgesics.
[Mh] Termos MeSH primário: Analgesia/métodos
Analgésicos não Entorpecentes/uso terapêutico
Analgésicos Opioides/uso terapêutico
Dor Pós-Operatória/tratamento farmacológico
Esplenectomia
Trombocitopenia/cirurgia
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Acetaminofen/efeitos adversos
Acetaminofen/uso terapêutico
Adulto
Analgésicos não Entorpecentes/administração & dosagem
Analgésicos não Entorpecentes/efeitos adversos
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/efeitos adversos
Plaquetas/citologia
Quimioterapia Combinada
Feminino
Seres Humanos
Masculino
Meia-Idade
Nefopam/administração & dosagem
Nefopam/efeitos adversos
Nefopam/uso terapêutico
Contagem de Plaquetas
Promedol/administração & dosagem
Promedol/efeitos adversos
Promedol/uso terapêutico
Trombocitopenia/sangue
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 362O9ITL9D (Acetaminophen); 4UP8060B7J (Nefopam); 64-39-1 (Promedol)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150406
[Lr] Data última revisão:
150406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150407
[St] Status:MEDLINE


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Fotocópia
[PMID]:25335384
[Ti] Título:[Periods of post-anesthetic rehabilitation and anesthesia dosage for laparoscopic cholecystectomy: retrospective investigation].
[So] Source:Eksp Klin Farmakol;77(8):11-5, 2014.
[Is] ISSN:0869-2092
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A retrospective descriptive nonrandomized cohort study of 585 anesthesia cards of patients who had undergone planned laparoscopic cholecystectomy showed no effect of the patient age and sex on the length of post-anesthetic rehabilitation period. The doses of sodium thiopental, ketamine, and trimeperidine affect the length of these periods by no more than 12%. Further search for and studying of factors affecting the duration of post-anesthetic rehabilitation is required in order to improve the safety and adequacy of general anesthesia.
[Mh] Termos MeSH primário: Anestésicos Intravenosos/uso terapêutico
Colecistectomia Laparoscópica/reabilitação
Ketamina/uso terapêutico
Dor/prevenção & controle
Promedol/uso terapêutico
Tiopental/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Anestesia Geral
Feminino
Seres Humanos
Masculino
Meia-Idade
Dor/reabilitação
Período Pós-Operatório
Estudos Retrospectivos
Fatores Sexuais
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 64-39-1 (Promedol); 690G0D6V8H (Ketamine); JI8Z5M7NA3 (Thiopental)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141023
[St] Status:MEDLINE


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Fotocópia
[PMID]:25026803
[Au] Autor:Shulutko EM; Levchenko OK; Gorodetskii VM; Gemdzhian ÉG; Koniashina NI; Krechetova AV
[Ti] Título:[Analgesia in hemophiliac patients during orthopedic surgery].
[So] Source:Ter Arkh;86(5):56-61, 2014.
[Is] ISSN:0040-3660
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To develop an effective and safe analgesic regimen (by minimizing the proportion of narcotic analgesics) in hemophiliac patients in the perioperative period during high-trauma surgeries (total knee and hip replacements). SUBJECTS AND METHODS: The prospective study included 24 patients aged 22 to 57 years (median age 38 years) with severe congenital hemophilia A (n = 22) and B (n = 2), who had undergone knee (n = 18) or hip (n = 6) replacements in the Hematology Research Center, Russian Ministry of Health of the Russian Federation, in 2013. Two analgesic regimens (a) paracetamol with trimeperidine; b) paracetamol and ketamine with trimeperidine) were used. To assess pain intensity, the authors used scoring scales: a visual analogue scale (VAS) and a numeric rating scale (NRS). The effect of paracetamol on hemostasis was evaluated on the basis of thromboelastogram and coagulogram readings. Possible paracetamol hepatotoxicity was assessed analyzing liver enzymes. RESULTS: An interview has shown that 66% of the hemophiliac patients regularly take analgesics for chronic pain syndrome, among them 29% use narcotic analgesics. It is difficult to achieve perioperative analgesia in these patients. The dosage of narcotics can be decreased (that of trimeperidine on an average from 80 to 45 mg/day) in the early postoperative period if non-narcotic analgesics, such as paracetamol 4 g/day, are incorporated into the analgesic regimen. Paracetamol promotes pain relief to moderate and mild (not more than 40-50 VAS scores and 3-4 NRS scores), without affecting hemostasis (the thromboelastogram readings differed statistically insignificantly; the coagulation index was 0.6-1.6) and without having a hepatotoxic effect. CONCLUSION: The systemic use of analgesics in hemophiliac patients considerably makes postoperative analgesia difficult. The use of paracetamol with trimeperidine within the first 24 hours after high-trauma surgeries in hemophiliac patients (even if they have hepatitis C) is rather effective and safe.
[Mh] Termos MeSH primário: Acetaminofen
Artroplastia de Quadril/métodos
Artroplastia do Joelho/métodos
Coagulação Sanguínea/efeitos dos fármacos
Hemofilia A
Dor Pós-Operatória
Promedol
[Mh] Termos MeSH secundário: Acetaminofen/administração & dosagem
Acetaminofen/efeitos adversos
Adulto
Analgésicos/administração & dosagem
Analgésicos/efeitos adversos
Testes de Coagulação Sanguínea/métodos
Doenças Ósseas/cirurgia
Monitoramento de Medicamentos
Quimioterapia Combinada/métodos
Feminino
Hemofilia A/sangue
Hemofilia A/complicações
Seres Humanos
Masculino
Meia-Idade
Manejo da Dor/métodos
Medição da Dor
Dor Pós-Operatória/complicações
Dor Pós-Operatória/diagnóstico
Dor Pós-Operatória/tratamento farmacológico
Cuidados Pós-Operatórios/métodos
Promedol/administração & dosagem
Promedol/efeitos adversos
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 362O9ITL9D (Acetaminophen); 64-39-1 (Promedol)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140716
[Lr] Data última revisão:
140716
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140717
[St] Status:MEDLINE


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Fotocópia
[PMID]:24749259
[Au] Autor:Gur'ianov VA; Nosenko MM; Gadzhibekov NCh; Ialich AIu; Aliautdin RN; Tolmachev GN
[Ti] Título:[Dexmedetomidine use for postoperative adrenergic analgesia and sedation in abdominal surgery].
[So] Source:Anesteziol Reanimatol;(6):21-4, 2013 Nov-Dec.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Comparative study of postoperative analgesia and sedation with trimeperidine and dexmedetomidine and their effects on haemodynamics and vegetative nervous system was performed. Assessment of analgesia and sedation during vagotonia (first part of the study) and hypokinetic type of haemodynamics (second part of the study) was carried out with visual analogue scale (VAS) and Richmond scale. Results of the study showed that dexmedetomidine is more effective and safer than trimeperidine for analgesia and sedation in patients with spontaneous breathing after abdominal surgery. Dexmedetomidine use allows keeping optimal type of haemodynamics and vegetative nervous system parameters on first day of postoperative period.
[Mh] Termos MeSH primário: Abdome/cirurgia
Analgésicos não Entorpecentes/uso terapêutico
Dexmedetomidina/uso terapêutico
Hipnóticos e Sedativos/uso terapêutico
Dor Pós-Operatória/prevenção & controle
Receptores Adrenérgicos alfa 2/metabolismo
[Mh] Termos MeSH secundário: Analgésicos não Entorpecentes/administração & dosagem
Analgésicos não Entorpecentes/efeitos adversos
Sedação Consciente/métodos
Dexmedetomidina/administração & dosagem
Dexmedetomidina/efeitos adversos
Hemodinâmica/efeitos dos fármacos
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Hipnóticos e Sedativos/efeitos adversos
Dor Pós-Operatória/metabolismo
Sistema Nervoso Parassimpático/efeitos dos fármacos
Promedol/administração & dosagem
Promedol/efeitos adversos
Promedol/uso terapêutico
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Hypnotics and Sedatives); 0 (Receptors, Adrenergic, alpha-2); 64-39-1 (Promedol); 67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:140422
[Lr] Data última revisão:
140422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140423
[St] Status:MEDLINE


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Fotocópia
[PMID]:24624851
[Au] Autor:Eremenko AA; Sorokina LS; Pavlov MV
[Ti] Título:[Ketoprophen and nefopam combination for postoperative analgesia with minimal use of narcotic analgesics in cardio-surgical patients].
[So] Source:Anesteziol Reanimatol;(5):11-5, 2013 Sep-Oct.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:4 combinations of analgesia were studied: 1) Nefopam and patient-controlled analgesia (PCA) with Trimeperidine; 2) Ketoprofen (100 microg each 12 hours intramuscular) and PCA with Trimeperidine; 3) Nefopam, Ketoprofen and PCA with Trimeperidine; 4) PCA with Trimeperidine as monotherapy in early postoperative period in cardio-surgical patients. 80 patients (age from 40 to 70) were divided into 4 groups, 20 patients in each group. Administration of Nefopam and Ketoprofen before extubation reduced the intensity of pain syndrome (in average on 90%) and promoted the early stirring up of patients. Combination of Nefopam and Ketoprofen provided the most expressed analgesic and opioids-saving effects. In this group average amount of Trimeperidine per 24 hours was 14.7 microg that was 4.9 times less than in group of PCA with Trimeperidine as monotherapy. Dynamics of maximal inspiratory capacity of the lungs in the first three groups was better than in group of PCA with Trimeperidine as monotherapy beginning from 6th hour of study. In common undesirable effects was connected with Trimeperidine administration and depended on its dose. The frequency of nausea, vomit, dizziness and weakness was authentically higher in the group of PCA with Trimeperidine as monotherapy than in other groups.
[Mh] Termos MeSH primário: Analgésicos não Entorpecentes/uso terapêutico
Analgésicos Opioides/uso terapêutico
Procedimentos Cirúrgicos Cardíacos
Cetoprofeno/uso terapêutico
Nefopam/uso terapêutico
Dor Pós-Operatória/prevenção & controle
Promedol/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Analgesia Controlada pelo Paciente
Analgésicos não Entorpecentes/administração & dosagem
Analgésicos não Entorpecentes/efeitos adversos
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/efeitos adversos
Relação Dose-Resposta a Droga
Esquema de Medicação
Quimioterapia Combinada
Seres Humanos
Cetoprofeno/administração & dosagem
Cetoprofeno/efeitos adversos
Meia-Idade
Nefopam/administração & dosagem
Nefopam/efeitos adversos
Promedol/administração & dosagem
Promedol/efeitos adversos
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 4UP8060B7J (Nefopam); 64-39-1 (Promedol); 90Y4QC304K (Ketoprofen)
[Em] Mês de entrada:1405
[Cu] Atualização por classe:140314
[Lr] Data última revisão:
140314
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140315
[St] Status:MEDLINE


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Fotocópia
[PMID]:24006615
[Au] Autor:Chuenkova EA; Ziganshina LE
[Ti] Título:[Phenotyping by total oxidative hepatic capacity in patients undergoing laparoscopic cholecystectomy: two categories of patients and duration of post-anesthesia rehabilitation].
[So] Source:Eksp Klin Farmakol;76(7):35-8, 2013.
[Is] ISSN:0869-2092
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:In patients, undergoing laparoscopy cholecystectomy, two phenotype categories were identified on the basis of the total oxidative hepatic capacity determined by antipyrine test, which differed by duration of post-anesthesia rehabilitation. The potential of antipyrine phenotyping for individualisation of anesthetics' dosing is discussed.
[Mh] Termos MeSH primário: Anestesia/estatística & dados numéricos
Anestésicos Intravenosos/uso terapêutico
Antipirina/metabolismo
Biomarcadores Farmacológicos/metabolismo
Colecistectomia Laparoscópica
Promedol/uso terapêutico
Tiopental/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Anestesia/métodos
Feminino
Seres Humanos
Pacientes Internados/classificação
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Meia-Idade
Oxirredução/efeitos dos fármacos
Medicina de Precisão
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Intravenous); 0 (Biomarkers, Pharmacological); 64-39-1 (Promedol); JI8Z5M7NA3 (Thiopental); T3CHA1B51H (Antipyrine)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130907
[St] Status:MEDLINE


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Fotocópia
[PMID]:24000658
[Au] Autor:Eremenko AA; Sorokina LS; Pavlov MV
[Ti] Título:[The use of central acting analgesic nefopam in postoperative analgesia in cardiac surgery patients].
[So] Source:Anesteziol Reanimatol;(2):78-82, 2013 Mar-Apr.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:A prospective, randomized, comparative study was conducted. 3 analgesia protocols were used: 1) patient controlled analgesia (PCA) with trimeperidine in combination with a nefopam constant infusion; 2) PCA with trimeperidine in combination with a nefopam bolus; 3) PCA with trimeperidine separately during early postoperative period in cardiac surgery patients. The study included 60 patients agedf rom 40 to 65 years of age (20 patients in each group). The analgesia efficacy was evaluated with a 5-point verbal rating scale (VRS) for pain intensity and inspiratory lung capacity (ILC), measured with incentive spirometer. The safety of nefopam during early postoperative period in cardiac surgery patients was shown. The combination of nefopam and trimeperidine led to a more pronounced analgetic effect. Trimeperidine consumption was significantly lower in nefopam groups than in the group of isolated PCA. Wholly adverse effects were associated with trimeperidine and were dose-related The incidence of nausea, vomiting, dizziness, weakness, bowel paresis was significantly higher in isolated PCA group than in the other two groups.
[Mh] Termos MeSH primário: Analgesia/métodos
Analgésicos não Entorpecentes/uso terapêutico
Procedimentos Cirúrgicos Cardíacos
Nefopam/uso terapêutico
Dor Pós-Operatória/tratamento farmacológico
[Mh] Termos MeSH secundário: Analgésicos não Entorpecentes/administração & dosagem
Analgésicos Opioides/administração & dosagem
Analgésicos Opioides/efeitos adversos
Analgésicos Opioides/uso terapêutico
Procedimentos Cirúrgicos Cardíacos/métodos
Esquema de Medicação
Quimioterapia Combinada
Feminino
Seres Humanos
Infusões Intravenosas
Masculino
Meia-Idade
Nefopam/administração & dosagem
Nefopam/efeitos adversos
Medição da Dor
Promedol/administração & dosagem
Promedol/efeitos adversos
Promedol/uso terapêutico
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 4UP8060B7J (Nefopam); 64-39-1 (Promedol)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130905
[St] Status:MEDLINE


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[PMID]:23987036
[Au] Autor:Kurochkin MIu
[Ti] Título:[Caudal-epidural injection of adjuvants and local anaesthetics in the newborns undergoing surgery].
[So] Source:Klin Khir;(6):66-8, 2013 Jun.
[Is] ISSN:0023-2130
[Cp] País de publicação:Ukraine
[La] Idioma:rus
[Ab] Resumo:In 45 newborns, operated on for the inborn failures of gut, the markers of stress and indices of central hemodynamics were studied up. General anaesthesia was applied together with caudal-epidural injection of local anaesthetics in 15 newborns, in 15--the adjuvants--klophelline and promedol--were added to local anaesthetics, in 15--a standard atharalgesia was used. The best and most durable effect was noted while application of anesthesia in combination with adjuvants.
[Mh] Termos MeSH primário: Adjuvantes Anestésicos
Anestésicos Locais
Íleo/anormalidades
Atresia Intestinal/cirurgia
Jejuno/anormalidades
[Mh] Termos MeSH secundário: Anestesia Epidural/métodos
Anestesia Geral/métodos
Biomarcadores/sangue
Clonidina
Fentanila
Hemodinâmica
Seres Humanos
Recém-Nascido
Injeções Epidurais
Promedol
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adjuvants, Anesthesia); 0 (Anesthetics, Local); 0 (Biomarkers); 64-39-1 (Promedol); MN3L5RMN02 (Clonidine); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130831
[St] Status:MEDLINE



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