[PMID]: | 27913936 |
[Au] Autor: | Yudin MA; Vengerovich NG; Sagalov GS; Vahvijanen MS; Bykov VN; Chepur SV |
[Ad] Endereço: | State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation, St. Petersburg, Russia. |
[Ti] Título: | Changes in Respiratory Function during Treatment with Combination of Analgesic Substances Trimeperidine and Dexmedetomidine. |
[So] Source: | Bull Exp Biol Med;162(2):215-219, 2016 Dec. |
[Is] ISSN: | 1573-8221 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | The effects of analgesic substances trimeperidine and dexmedetomidine and their combinations in different proportions (0.75:0.25, 0.5:0.5, 0.25:0.75 of the medium effective doses of each substance) on respiratory function was studied in experiments on rats. Administration of substances in 1 ED by analgesic effect (corresponded to medium therapeutic dose of trimeperidine in humans) was characterized by significantly longer suppression of respiration over 90 min in comparison with combined treatment with these substances. Administration of the substances in a dose of 8 ED by analgesic effect (corresponded to daily therapeutic dose) over 60 min was followed by more than 3-fold reduction in respiration frequency and respiratory minute volume, more pronounced in animals receiving trimeperidine. Combined administration of these drugs in the specifi ed dose induced less pronounced suppression of respiration and combined administration of trimeperidine and dexmedetomidine in proportion of 0.75:0.25 signifi cantly reduced the period of restoration of respiratory parameters in comparison with animals receiving single substances. |
[Mh] Termos MeSH primário: |
Analgésicos não Entorpecentes/farmacologia Analgésicos Opioides/farmacologia Dexmedetomidina/farmacologia Promedol/farmacologia Respiração/efeitos dos fármacos
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[Mh] Termos MeSH secundário: |
Animais Animais não Endogâmicos Esquema de Medicação Combinação de Medicamentos Cálculos da Dosagem de Medicamento Masculino Ratos Testes de Função Respiratória
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Analgesics, Non-Narcotic); 0 (Analgesics, Opioid); 0 (Drug Combinations); 64-39-1 (Promedol); 67VB76HONO (Dexmedetomidine) |
[Em] Mês de entrada: | 1702 |
[Cu] Atualização por classe: | 170210 |
[Lr] Data última revisão:
| 170210 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161204 |
[St] Status: | MEDLINE |
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