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Pesquisa : D03.066.515.635 [Categoria DeCS]
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[PMID]:27840352
[Au] Autor:Yuri P; Ali Z; Rasyid N; Birowo P
[Ad] Endereço:Department of Surgery, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia. prahara.yuri@gmail.com.
[Ti] Título:Effects of Pipemidic Acid, Phenazopyridine HCL and Sodium Diclofenac on Pain Perception Following Endoscopic Urological Surgery: Double-blinded Randomized-Controlled Trial.
[So] Source:Acta Med Indones;48(3):184-192, 2016 Jul.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:AIM: to evaluate the analgesic effect, the side effects and the safety of analgesics following endoscopic urological procedure. METHODS: eighty patients who underwent endoscopic urological surgery at Kardinah Hospital, Tegal from June to July 2015 were divided into four groups. The experimental group was administered analgesic for 4 days pipemidic acid (A) 400 mg bid, or phenazopyridine (B) 200 mg tid, or sodium diclofenac (C) 50 mg bid and the control (D) group was administered placebo tid for 4 days. The analgesic effects were assessed using Visual Analog Scale (VAS). Association between variables was assessed using Cramers V and Kruskall Wallis. RESULTS: the endoscopic urological procedures consisted of 30 patients for URS, 6 patients for lithotripsy, 17 patients for TURP, 24 patients for removal JJ stent and 3 patients for cystoscopy. The mean age of group A, B, C and D (control) was 50.1 (13.7), 50.7 (14.8), 49.1 (13.4), and 49.6 (14.3) years, respectively, and follow-up period was 7 days. The VAS score in all experimental groups was less than control group on day 1 to 7 following endoscopic urological procedures (p<0.05). In the experimental group, there was no difference between groups B and C (p>0.05). Group A demonstrated a more favourable analgesic effect than B and C (p<0.05). No serious side effects were detected in any of the cases. CONCLUSION: we conclude that oral analgesics are effective for pain relief following endoscopic urological surgery. Pipemidic acid was found to have a superior analgesic effect than phenazopyridine HCl and sodium diclofenac.
[Mh] Termos MeSH primário: Anestésicos Locais/uso terapêutico
Anti-Infecciosos Urinários/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Diclofenaco/uso terapêutico
Percepção da Dor
Fenazopiridina/uso terapêutico
Ácido Pipemídico/uso terapêutico
Procedimentos Cirúrgicos Urológicos
[Mh] Termos MeSH secundário: Método Duplo-Cego
Endoscopia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Anti-Infective Agents, Urinary); 0 (Anti-Inflammatory Agents, Non-Steroidal); 144O8QL0L1 (Diclofenac); K2J09EMJ52 (Phenazopyridine); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:26979255
[Au] Autor:Mjos KD; Polishchuk E; Abrams MJ; Orvig C
[Ad] Endereço:Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
[Ti] Título:Synthesis, characterization, and evaluation of the antimicrobial potential of copper(II) coordination complexes with quinolone and p-xylenyl-linked quinolone ligands.
[So] Source:J Inorg Biochem;162:280-285, 2016 Sep.
[Is] ISSN:1873-3344
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The antimicrobial properties of copper have been known to mankind since the ancient times. In a coordination chemistry approach to develop novel antimicrobial agents, the quinolone antimicrobial agents ciprofloxacin (Hcipro) and pipemidic acid (Hpia), as well as dimers thereof (piperazinyl-linked with a p-xylenyl moiety) were complexed with copper(II). The synthesis and antimicrobial evaluation of bis(ciprofloxacino)copper(II) [Cu(cipro) ], bis(pipemido)copper(II) [Cu(pia) ], and the corresponding dimer complexes, [Cu (ciproXcipro) ] and [Cu (piaXpia) ], are reported. No combinational or synergistic effect between copper(II) and the respective quinolone ligands was observed in vitro.
[Mh] Termos MeSH primário: Antibacterianos/síntese química
Ciprofloxacino/química
Complexos de Coordenação/síntese química
Cobre/química
Ácido Pipemídico/química
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Complexos de Coordenação/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/crescimento & desenvolvimento
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/crescimento & desenvolvimento
Ligantes
Viabilidade Microbiana/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Coordination Complexes); 0 (Ligands); 5E8K9I0O4U (Ciprofloxacin); 789U1901C5 (Copper); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160317
[St] Status:MEDLINE


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[PMID]:26094378
[Au] Autor:Andrjuhin MI; Motin PI; Pul'bere SA; Israfilov MN
[Ti] Título:[REHABILITATION OF PATIENTS WITH URIC ACID AND MIXED UROLITHIASIS].
[So] Source:Urologiia;(1):4-7, 2015 Jan-Feb.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:This paper presents evaluation of rehabilitation effectiveness of 113 patients aged 19-78 years diagnosed as having mixed and uric acid stones. 88 patients with uric acid stones 0,5-2,5 cm were assigned to group 1 and treated with Trometamol N parenteral litholis and a complex metaprophilaxis by dietary supplements Prolit and Urisan. 25 patients with mixed stones 1-3,5 cm were allocated to group 2 and treated with external shock wave lithotripsy and complex metaprophilaxis by dietary supplements Prolit Super Septo and Urisan. Positive results were achieved in all the patients. In the patients of group 1 the stones were completely dissolved. In group 2 treatment resulted in stone disintegration and clearance of small fragments 0,4 cm after partial dissolution.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/administração & dosagem
Suplementos Nutricionais
Ácido Pipemídico/administração & dosagem
Ácido Úrico
Urolitíase/reabilitação
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Urolitíase/diagnóstico
Urolitíase/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 268B43MJ25 (Uric Acid); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:150622
[Lr] Data última revisão:
150622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150623
[St] Status:MEDLINE


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[PMID]:25730788
[Au] Autor:Shaheen G; Usmanghani K; Nazar H; Akhtar N
[Ad] Endereço:University College of Conventional Medicine, The Islamia University of Bahawalpur, Pakistan.
[Ti] Título:Clinical evaluation of herbal coded formulation Cran-off to Urixin in the treatment of urinary tract infection.
[So] Source:Pak J Pharm Sci;28(2):557-9, 2015 Mar.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Urinary Tract Infections are the largest group of infections after the respiratory tract infections. In 85% of the cases the causative organism is E. Coli. A clinical trial was conducted to evaluate the efficacy of coded herbal formulation "Cranoff" (Test drug) for the treatment of Urinary tract infection comparing with Urixin (Control). One hundred and thirty patients suffering from Urinary tract infection from both groups (Males: 45, mean age: 34±14 and females: 85, mean age: 33±13 year, range: 15-55) were enrolled in the trial and divided in to two groups according to treatment regimens. Cranoff (Test drug) 500mg two capsules and Urixin (Pipemidic Acid Trihydrate JP15) (Control) 400mg capsules twice daily were prescribed for 2-3 weeks. Urinary tract infection was improved in 23 (35.38%) patients out of 65 patients by the use of Cranoff (Test drug), and in 15 (23.07%) patients out of 65 by the use of Urixin (Control drug). Furthermore, there was a significant improvement in Urinary tract infection associated clinical features as compared to Urixin. It is concluded that Cranoff possesses a therapeutic value for the improvement of urinary tract infection and its associated symptoms as compared to Urixin.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/uso terapêutico
Fitoterapia
Ácido Pipemídico/uso terapêutico
Infecções Urinárias/tratamento farmacológico
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1504
[Cu] Atualização por classe:150303
[Lr] Data última revisão:
150303
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE


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[PMID]:24453852
[Au] Autor:Chiang BJ; Pu YS; Chung SD; Liu SP; Yu HJ; Wang SM; Chang HC; Chiang IN; Huang CY
[Ad] Endereço:Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung Shan S. Road (Zhongshan S. Road), Zhongzheng District, Taipei City 10002, Taiwan ; Department of Urology, Cardinal Tien Hospital, College of Medicine, Fu Jen Catholic University,
[Ti] Título:Quinolone prophylaxis in transrectal ultrasound guided prostate biopsy: an eight-year single center experience.
[So] Source:ScientificWorldJournal;2013:452107, 2013.
[Is] ISSN:1537-744X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We retrospectively evaluated the efficacy of prophylaxis with pipemidic acid and levofloxacin in transrectal ultrasound guided prostate biopsy (TRUSP-Bx). From January 2002 to December 2004, patients receiving oral pipemidic acid 500 mg twice daily for three days with or without a preoperative intravenous cefazolin 1 gm injection comprised group A. Between January 2005 and December 2009, patients receiving oral levofloxacin 500 mg one hour before biopsy comprised group B. We calculated the annual febrile urinary tract infection (fUTI) rates. Patients' characteristics, including age, prophylactic antibiotics, biopsy core numbers, pathologic results, PSA, and the spectrums and susceptibility of pathogens, were also evaluated. A total of 1313 (35.5%) patients belonged to group A, while 2381 (64.5%) patients belonged to group B. Seventy-three patients experienced postoperative infectious complications. There was a significant difference in the fUTI rate between groups A and B (3.7% versus 1.0%, P < 0.001). The yearly fUTI rates varied from 0.6 to 3.9% between 2002 and 2009. Of the 73 patients with fUTI, those receiving levofloxacin prophylaxis were more likely to harbor fluoroquinolone-resistant pathogens (P < 0.001). E. coli was the most common pathogen in both groups. Levofloxacin remains effective and appears superior to pipemidic acid based prophylaxis.
[Mh] Termos MeSH primário: Antibioticoprofilaxia/métodos
Biópsia/métodos
Levofloxacino/uso terapêutico
Ácido Pipemídico/uso terapêutico
Próstata/patologia
Ultrassom Focalizado Transretal de Alta Intensidade/métodos
Infecções Urinárias/prevenção & controle
[Mh] Termos MeSH secundário: Biópsia/efeitos adversos
Cefazolina/uso terapêutico
Seres Humanos
Masculino
Estudos Retrospectivos
Taiwan
Ultrassom Focalizado Transretal de Alta Intensidade/efeitos adversos
Infecções Urinárias/patologia
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
6GNT3Y5LMF (Levofloxacin); IHS69L0Y4T (Cefazolin); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140124
[St] Status:MEDLINE
[do] DOI:10.1155/2013/452107


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[PMID]:24429818
[Au] Autor:Engevik MA; Faletti CJ; Paulmichl M; Worrell RT
[Ad] Endereço:Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine Cincinnati, Cincinnati, OH, USA.
[Ti] Título:Prebiotic properties of galursan HF 7K on mouse gut microbiota.
[So] Source:Cell Physiol Biochem;32(7):96-110, 2013.
[Is] ISSN:1421-9778
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: With the rise of antibiotic resistance, new alternatives are being sought to effectively modulate the characteristics of gut microbiota to obtain pathogen resistance without the use of antibiotics. In the past, an oligosaccharide derivative of carrots, galursan HF 7K (GHF7K), has been used clinically in Austria and recently in the fowl-industry to promote health. This study examined the potential role of GHF7K as a prebiotic to alter the gut microbiota in mice. METHODS: Mice were fed either a control diet (CT) or a diet containing 2% GHF7K in the water and chow for 2 weeks, and weight, food and water consumption, gut microbiota and ion composition of the intestinal fluid were examined. RESULTS: Dietary supplement of GHF7K did not alter mouse weight or daily food consumption. Additionally, no changes were observed in the total number of luminal or mucosa-associated bacteria populations in GHF7K-fed mice. GHF7K supplementation significantly altered the composition of luminal, and to a less extent, mucosa-associated bacterial populations at the level of the phyla, with region-specific differences. Similar to antibiotic use, Proteobacteria number was increased in the ileum and colon of GHF7K-fed mice, with no changes in the number of beneficial Lactobacillus and Bifidobacterium genera of phylum Firmicutes. Corresponding with the altered gut microbiota, changes in the ion composition of the intestinal fluid were observed. An increased Cl(-) concentration was observed in the duodenum and jejunum, while the Na(+) concentration was increased in the cecum of GHF7K-fed mice. Decreases were observed in the K(+) concentration in the cecum and distal colon. CONCLUSIONS: Dietary supplement of GHF7K is capable of altering the gut microbiota, which correlates to changes in the intestinal environment. These data suggest that GHF7K dietary supplement can purposefully be used to alter the gut microbiota, and thus could potentially represent an alternative approach to prophylactic antibiotic use.
[Mh] Termos MeSH primário: Intestinos/efeitos dos fármacos
Microbiota/efeitos dos fármacos
Ácido Pipemídico/administração & dosagem
Prebióticos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/administração & dosagem
Bactérias/efeitos dos fármacos
Bactérias/crescimento & desenvolvimento
Peso Corporal
Suplementos Nutricionais
Intestinos/microbiologia
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Prebiotics); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140116
[Lr] Data última revisão:
140116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140117
[St] Status:MEDLINE
[do] DOI:10.1159/000356631


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[PMID]:23799358
[Au] Autor:Iacovino R; Rapuano F; Caso JV; Russo A; Lavorgna M; Russo C; Isidori M; Russo L; Malgieri G; Isernia C
[Ad] Endereço:Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Via A. Vivaldi 43, 81100 Caserta, Italy. rosa.iacovino@unina2.it.
[Ti] Título:ß-Cyclodextrin inclusion complex to improve physicochemical properties of pipemidic acid: characterization and bioactivity evaluation.
[So] Source:Int J Mol Sci;14(7):13022-41, 2013 Jun 25.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aptitude of cyclodextrins (CDs) to form host-guest complexes has prompted an increase in the development of new drug formulations. In this study, the inclusion complexes of pipemidic acid (HPPA), a therapeutic agent for urinary tract infections, with native ß-CD were prepared in solid state by kneading method and confirmed by FT-IR and 1H NMR. The inclusion complex formation was also characterized in aqueous solution at different pH via UV-Vis titration and phase solubility studies obtaining the stability constant. The 1:1 stoichiometry was established by a Job plot and the inclusion mechanism was clarified using docking experiments. Finally, the antibacterial activity of HPPA and its inclusion complex was tested on P. aeruginosa, E. coli and S. aureus to determine the respective EC50s and EC90s. The results showed that the antibacterial activity of HPPA:ß-CD against E. coli and S. aureus is higher than that of HPPA. Furthermore, HPPA and HPPA:ß-CD, tested on human hepatoblastoma HepG2 and MCF-7 cell lines by MTT assay, exhibited, for the first time, antitumor activities, and the complex revealed a higher activity than that of HPPA. The use of ß-CD allows an increase in the aqueous solubility of the drug, its bioavailability and then its bioactivity.
[Mh] Termos MeSH primário: Ácido Pipemídico
beta-Ciclodextrinas
[Mh] Termos MeSH secundário: Varredura Diferencial de Calorimetria
Ciclodextrinas/química
Escherichia coli
Seres Humanos
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier
Staphylococcus aureus
beta-Ciclodextrinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclodextrins); 0 (beta-Cyclodextrins); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130627
[St] Status:MEDLINE
[do] DOI:10.3390/ijms140713022


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[PMID]:23342610
[Au] Autor:Avdoshin VP; Andriukhin MI; Annenkov AV; Israfilov MN
[Ti] Título:[Treatment and metaphylaxis of gout complicated by nephropathy and urolithiasis].
[So] Source:Urologiia;(5):18-20, 2012 Sep-Oct.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The evaluation of clinical efficacy of combined treatment and metaphylaxis in 58 patients with gout complicated by nephropathy and urolithiasis was performed. The study included 41 (71%) men and 27 (29%) women aged 44 to 88 years (mean age - 58 +/- 7 years). All patients received parenteral therapy with trometamol H, 5 -10 infusion for the course, an average of 7 infusions. For the metaphylaxis, all patients received biologically active supplement urisan 2 tablets 2 times a day during next three months against the background of drug therapy. Findings indicate a high clinical efficacy of the trometamol H in the combined treatment of patients with gout, complicated by nephropathy and urolithiasis, considering that improvement of renal function, microcirculation in the renal parenchyma, increased glomerular filtration rate, normalization of nitrogenous wastes levels, partial or complete dissolution of concretions of the kidneys, a significant decrease in the tophs size, an increase in motor activity were observed, which ultimately improves the quality of life for these patients. Metaphylaxis using urisan for 3 months on a background of traditional therapy contributed to a stable normalization of blood uric acid levels, which prevented the exacerbation of underlying disease and recurrent stone formation. These data allow to recommend reducing the dose of traditional anti-gout drugs and conducting repeated course of metaphylaxis with the urisan after 5-6 months during 3 months.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/administração & dosagem
Excipientes/administração & dosagem
Gota
Nefropatias
Ácido Pipemídico/administração & dosagem
Trometamina/administração & dosagem
Urolitíase
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Taxa de Filtração Glomerular/efeitos dos fármacos
Gota/sangue
Gota/complicações
Gota/fisiopatologia
Gota/prevenção & controle
Seres Humanos
Nefropatias/sangue
Nefropatias/etiologia
Nefropatias/fisiopatologia
Nefropatias/prevenção & controle
Masculino
Meia-Idade
Fatores de Tempo
Ácido Úrico/sangue
Urolitíase/sangue
Urolitíase/etiologia
Urolitíase/fisiopatologia
Urolitíase/prevenção & controle
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 0 (Excipients); 023C2WHX2V (Tromethamine); 268B43MJ25 (Uric Acid); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130125
[St] Status:MEDLINE


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[PMID]:23074924
[Au] Autor:Avdoshin VP; Andriukhin MI; Israfilov MN; Annenkov AV; Atamanova EA
[Ti] Título:[Treatment and metaphylaxis of urate and mixed urolithiasis].
[So] Source:Urologiia;(3):7-8, 10, 2012 May-Jun.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:We estimated the efficacy of combined treatment and metaphylaxis of urate and mixed urolithiasis in 87 patients aged 18-87 years. The patients were divided into two groups: 68 patients of group 1 (the size of the concrements between 5-25 mm) have undergone parenteral litholysis of the drug trometamol N and metaphylaxis with biologically active additives prolit and urisan; 19 patients of group 2 have undergone extracorporeal shock-wave lithotripsy with parenteral litholysis and metaphylaxis by using biologically active additives prolit septo and urisan. Positive results were achieved in all the patients. In group 1 the concrements dissolved completely. In group 2 small fragments up to 4 mm eliminated after partial solution.
[Mh] Termos MeSH primário: Anti-Infecciosos Urinários/administração & dosagem
Excipientes/administração & dosagem
Litotripsia
Ácido Pipemídico/administração & dosagem
Trometamina/administração & dosagem
Ácido Úrico/metabolismo
Urolitíase
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Urolitíase/metabolismo
Urolitíase/patologia
Urolitíase/terapia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents, Urinary); 0 (Excipients); 023C2WHX2V (Tromethamine); 268B43MJ25 (Uric Acid); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121019
[St] Status:MEDLINE


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[PMID]:21683365
[Au] Autor:Herrera-Herrera AV; Hernández-Borges J; Rodríguez-Delgado MA; Herrero M; Cifuentes A
[Ad] Endereço:Department of Analytical Chemistry, Nutrition and Food Science, Universidad de La Laguna (ULL). Avenida Astrofísico Francisco Sánchez, s/n. 38206 La Laguna (Tenerife), Spain.
[Ti] Título:Determination of quinolone residues in infant and young children powdered milk combining solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry.
[So] Source:J Chromatogr A;1218(42):7608-14, 2011 Oct 21.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present work describes a method based on solid-phase extraction (SPE) and ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) for the simultaneous determination of three quinolones (pipemidic acid, oxolinic acid and flumequine) and twelve fluoroquinolones (marbofloxacin, fleroxacin, pefloxacin, levofloxacin, norfloxacin, ciprofloxacin, enrofloxacin, danofloxacin, lomefloxacin, difloxacin, sarafloxacin, and moxifloxacin) in different infant and young children powdered milks. After suitable deproteination of the reconstituted powdered samples, a SPE procedure was developed providing recovery values higher than 84% (RSDs lower than 13%) for all the analytes, with limits of detection between 0.04 and 0.52 µg/kg. UPLC-MS/MS analyses were carried out in less than 10 min. Sixteen infant and young children powdered milk samples of different origin, type and composition bought at Spanish markets were analyzed. Residues of the selected antibiotics were not detected in any of the analyzed samples.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Resíduos de Drogas/análise
Fluoroquinolonas/análise
Fórmulas Infantis/química
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Acetonitrilos
Antibacterianos/análise
Seres Humanos
Lactente
Ácido Oxolínico/análise
Ácido Pipemídico/análise
Análise de Regressão
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Anti-Bacterial Agents); 0 (Fluoroquinolones); L0A22B22FT (Oxolinic Acid); LT12J5HVR8 (Pipemidic Acid); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1201
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110621
[St] Status:MEDLINE
[do] DOI:10.1016/j.chroma.2011.05.066



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