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[PMID]:28703314
[Au] Autor:Le PM; Srivastava V; Nguyen TT; Pradines B; Madamet M; Mosnier J; Trinh TT; Lee H
[Ad] Endereço:Measurement Science and Standards, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada.
[Ti] Título:Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit.
[So] Source:Phytother Res;31(9):1357-1368, 2017 Sep.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extracts from the tubers of Stephania venosa (Blum) Spreng growing in Vietnam significantly inhibited cell proliferation against a number of cancer cells including HeLa, MDA-MB231 and MCF-7 cells. A bioassay-guided fractionation led to the isolation of four aporphine and one tetrahydroprotoberberine alkaloids: dehydrocrebanine 1, tetrahydropalmatine 2, stephanine 3, crebanine 4 and O-methylbulbocapnine 5. The characterization of these compounds was based on MS, NMR and published data. A study by structure-bioactivity relationship on these isolates showed that stephanine is the most active compound. Cell biological studies showed that stephanine induces the reverse of mitotic exit, eventually leading to cell death by apoptosis. This data suggests that stephanine has a unique mode of cell-killing activity against cancer cells, which is seldom observed with known synthetic compounds. In addition to its anticancer property, our data from an in vitro study showed that S. venosa also possesses effective antiplasmodial activity and stephanine was also the most interesting compound but is the most cytotoxic with the lowest selectivity index. Copyright © 2017 Her Majesty the Queen in Right of Canada Phytotherapy Research StartCopTextCopyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Aporfinas/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/farmacologia
Alcaloides de Berberina/química
Alcaloides de Berberina/farmacologia
Seres Humanos
Células MCF-7
Mitose/efeitos dos fármacos
Estrutura Molecular
Fitoterapia
Tubérculos/química
Plasmodium falciparum/efeitos dos fármacos
Stephania/química
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antimalarials); 0 (Antineoplastic Agents, Phytogenic); 0 (Aporphines); 0 (Berberine Alkaloids); 0 (Plant Extracts); 13NS2KTD6H (aporphine); 25127-29-1 (crebanine); 3X69CO5I79 (tetrahydropalmatine); 517-63-5 (stephanine); 728C74FB5Z (berbine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5861


  2 / 1360 MEDLINE  
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[PMID]:28570935
[Au] Autor:Wang J; Zheng D; Wang Y; Zhang C; Sun X
[Ad] Endereço:College of Life Sciences, Zaozhuang University, Zaozhuang 277160, China. Electronic address: jlwang8121@163.com.
[Ti] Título:Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1059:35-42, 2017 Aug 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To study the pharmacokinetics of Erhuang decoction extracts, a high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was established for the determination of effective substances in rat plasma. The extracts prepared by water extraction (WE) method were given to rats by oral administration. After collected from the orbital venous plexus, plasma was treated by protein precipitation method. Then, the concentration of index components, including baicalin, liquiritin, berberine, palmatine and glycyrrhetinic acid, were determined by HPLC-MS/MS. Gradient elution mode was used to the chromatographic separation with an Inertsil ODS-SP column (100 mm×2.1mm, 5µm), with acetonitrile and 0.1% formic acid containing 10mmolL ammonium acetate as the mobile phase. MS analysis was conducted by multiple reactions monitoring (MRM) with Electrospray Ionization (ESI). The extraction recoveries of the five active ingredients from plasma were greater than 86.04%, and the intra- and inter-day precisions were less than 16.57%. Results indicated that active ingredients in plasma of rats with oral administration of extracts showed certain difference in the pharmacokinetic parameters, which proved that the active ingredients were effectively absorbed. The established HPLC-MS/MS analytical method was sensitive and accurate, suitable for the pharmacokinetic study of active ingredients in Erhuang decoction.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/farmacocinética
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Berberina/sangue
Alcaloides de Berberina/sangue
Medicamentos de Ervas Chinesas/administração & dosagem
Flavanonas/sangue
Glucosídeos/sangue
Ácido Glicirretínico/sangue
Glycyrrhiza/química
Glycyrrhiza/metabolismo
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
Scutellaria baicalensis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (Coptidis rhizoma extract); 0 (Drugs, Chinese Herbal); 0 (Flavanones); 0 (Glucosides); 0I8Y3P32UF (Berberine); 49QAH60606 (baicalein); G50C034217 (palmatine); P540XA09DR (Glycyrrhetinic Acid); T0O79T74CD (liquiritin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE


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[PMID]:28557048
[Au] Autor:Yang YF; Zhou QL; Yang XW
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
[Ti] Título:Elucidation of Compatibility Interactions of Traditional Chinese Medicines: In Vitro Absorptions Across Caco-2 Monolayer of Coptidis Rhizoma and Euodiae Fructus in Zuojin and Fanzuojin Formulas as A Case.
[So] Source:Phytother Res;31(8):1220-1229, 2017 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Traditional Chinese medicines are often combined as formulae and interact with each other. As for Coptidis Rhizoma (CR) and Euodiae Fructus (EF), the most classical compatibilities were Zuojin (ZJF) and Fanzuojin formulas (FZJF) with reverse mixture ratios and opposite effects. To compare in vitro absorption interactions between CR and EF, bidirectional transports across Caco-2 cell monolayer of extracts of two formulas and equivalent single herbs were studied. Eighteen alkaloids from CR and EF were determined by liquid chromatography coupled to tandem mass spectrometry. Parameter apparent permeability coefficient (P ) and efflux rate (ER) values showed that most alkaloids were well or moderately absorbed and six quaternary protoberberine alkaloids from CR had obvious efflux. ZJF compatibilities reduced both P and ER values of three indole alkaloids, and increased ER values of two quinolone alkaloids from EF. FZJF compatibilities obviously affected the bidirectional P values of CR alkaloids, weakened ERs of five protoberberines from CR and enlarged ERs of two quinolones from EF. Conclusions were drawn that different compatibility ratios of CR and EF led to different interactions on the in vitro absorption of alkaloids. The results may provide a good reference for interaction studies on the compatibilities of traditional Chinese medicines. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Alcaloides/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Evodia/química
[Mh] Termos MeSH secundário: Alcaloides de Berberina/farmacocinética
Células CACO-2
Cromatografia Líquida de Alta Pressão
Frutas/química
Seres Humanos
Alcaloides de Indol/farmacocinética
Absorção Intestinal
Quinolonas/farmacocinética
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Berberine Alkaloids); 0 (Coptidis rhizoma extract); 0 (Drugs, Chinese Herbal); 0 (Indole Alkaloids); 0 (Quinolones); 0 (zuojin); 19716-69-9 (protoberberine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5843


  4 / 1360 MEDLINE  
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[PMID]:28551874
[Au] Autor:Lee BH; Chathuranga K; Uddin MB; Weeratunga P; Kim MS; Cho WK; Kim HI; Ma JY; Lee JS
[Ad] Endereço:College of Veterinary Medicine, Chungnam National University, Daejeon, 34134, Republic of Korea.
[Ti] Título:Coptidis Rhizoma extract inhibits replication of respiratory syncytial virus in vitro and in vivo by inducing antiviral state.
[So] Source:J Microbiol;55(6):488-498, 2017 Jun.
[Is] ISSN:1976-3794
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:Coptidis Rhizoma is derived from the dried rhizome of Ranunculaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respiratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death. This antiviral activity against RSV was through the induction of type I interferon-related signaling and the antiviral state in HEp2 cells. More importantly, oral administration of CRE exhibited prophylactic effects in BALB/c mice against RSV. In HPLC analysis, we found the presence of several compounds in the aqueous fraction and among them; we confirmed that palmatine was related to the antiviral properties and immunemodulation effect. Taken together, an extract of Coptidis Rhizoma and its components play roles as immunomodulators and could be a potential source as promising natural antivirals that can confer protection to RSV. These outcomes should encourage further allied studies in other natural products.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Medicamentos de Ervas Chinesas/farmacologia
Infecções por Vírus Respiratório Sincicial/tratamento farmacológico
Vírus Sincicial Respiratório Humano/crescimento & desenvolvimento
Replicação Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Alcaloides de Berberina/farmacologia
Linhagem Celular
Seres Humanos
Fatores Imunológicos/farmacologia
Interferon beta/metabolismo
Interleucina-6/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Extratos Vegetais/farmacologia
Vírus Sincicial Respiratório Humano/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Berberine Alkaloids); 0 (Coptidis rhizoma extract); 0 (Drugs, Chinese Herbal); 0 (IL6 protein, human); 0 (Immunologic Factors); 0 (Interleukin-6); 0 (Plant Extracts); 77238-31-4 (Interferon-beta); G50C034217 (palmatine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE
[do] DOI:10.1007/s12275-017-7088-x


  5 / 1360 MEDLINE  
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[PMID]:28359045
[Au] Autor:Chen J; Wang T; Xu S; Lin A; Yao H; Xie W; Zhu Z; Xu J
[Ad] Endereço:State Key Laboratory of Natural Medicines, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China.
[Ti] Título:Design, synthesis and biological evaluation of novel nitric oxide-donating protoberberine derivatives as antitumor agents.
[So] Source:Eur J Med Chem;132:173-183, 2017 May 26.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:A novel class of NO-donating protoberberine derivatives were synthesized and initially evaluated for their anti-hepatocellular carcinoma activities. Most of the compounds exhibited more potent activity against HepG2 cells than parent compounds berberine and palmatine. In particular, compound 15a exerted the strongest activity with an IC value of 1.36 µM. Moreover, most compounds released moderate levels of NO in vitro, and the antitumor activity of 15a in HepG2 cells was remarkably diminished by an NO scavenger. Interestingly, compound 15a displayed a broad-spectrum antitumor efficacy and possessed good selectivity between tumor cells (HepG2, SMMC-7721, HCT-116, HL-60) and normal liver LO-2 cells. The mechanism studies revealed that 15a blocked the G2 phase of the cell cycle and induced apoptosis of HepG2 cells by mitochondrial depolarization. Furthermore, 15a inhibited tumor growth in H22 liver cancer xenograft mouse model by 62.5% (w/w), which was significantly superior to parent compound palmatine (41.6%, w/w). Overall, the current study may provide a new approach for the discovery of novel antitumor agents.
[Mh] Termos MeSH primário: Antineoplásicos/química
Alcaloides de Berberina/química
Alcaloides de Berberina/farmacologia
Óxido Nítrico/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Células Hep G2
Xenoenxertos
Seres Humanos
Neoplasias Hepáticas/tratamento farmacológico
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Berberine Alkaloids); 19716-69-9 (protoberberine); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE


  6 / 1360 MEDLINE  
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[PMID]:28302402
[Au] Autor:Jeyakkumar P; Liu HB; Gopala L; Cheng Y; Peng XM; Geng RX; Zhou CH
[Ad] Endereço:Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
[Ti] Título:Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration.
[So] Source:Bioorg Med Chem Lett;27(8):1737-1743, 2017 04 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A series of novel benzimidazolyl tetrahydroprotoberberines were conveniently designed and efficiently synthesized from berberine via direct cyclization of tetrahydroprotoberberine aldehyde and o-phenylene diamines under metal-free aerobic oxidation. All the new compounds were characterized by IR, H NMR, C NMR and HRMS spectra. The antimicrobial evaluation revealed that the 5-fluorobenzimidazolyl derivative 5b was the most active antibacterial and antifungal molecule with broad spectrum in comparison to Berberine, Chloromycin, Norfloxacin and Fluconazole. It triggered almost no resistance development against MRSA even after 15 passages. Further studies demonstrated that compound 5b could not only effectively interact with Topo IA by hydrogen bonds, but also intercalate into calf thymus DNA and cleave pBR322 DNA, which might be responsible for its powerful bioactivities.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Benzimidazóis/química
Benzimidazóis/farmacologia
Alcaloides de Berberina/química
Alcaloides de Berberina/farmacologia
[Mh] Termos MeSH secundário: Animais
Bactérias/efeitos dos fármacos
Infecções Bacterianas/tratamento farmacológico
Bovinos
DNA/metabolismo
Fungos/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Simulação de Acoplamento Molecular
Micoses/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Benzimidazoles); 0 (Berberine Alkaloids); 728C74FB5Z (berbine); 9007-49-2 (DNA); 91080-16-9 (calf thymus DNA)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


  7 / 1360 MEDLINE  
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[PMID]:28278436
[Au] Autor:Chen G; Xu Y; Jing J; Mackie B; Zheng X; Zhang X; Wang J; Li X
[Ad] Endereço:College of Pharmacy, Liaoning University of Traditional Chinese Medicine, 77 Life One Road, DD port, Dalian 116600, China.
[Ti] Título:The anti-sepsis activity of the components of Huanglian Jiedu Decoction with high lipid A-binding affinity.
[So] Source:Int Immunopharmacol;46:87-96, 2017 May.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Huanglian Jiedu Decoction (HJD), one of the classic recipes for relieving toxicity and fever, is a common method for treating sepsis in China. However, the effective components of HJD have not yet been identified. This experiment was carried out to elucidate the effective components of HJD against sepsis. Thus, seven fractions from HJD were tested using a biosensor to test their affinity for lipid A. The components obtained that had high lipid A-binding fractions were further separated, and their affinities to lipid A were assessed with the aid of a biosensor. The levels of LPS in the blood were measured, and pathology experiments were conducted. The LPS levels and mRNA expression analysis of TNF-α and IL-6 of the cell supernatant and animal tissue were evaluated to investigate the molecular mechanisms. Palmatine showed the highest affinity to lipid A and was evaluated by in vitro and in vivo experiments. The results of the in vitro and in vivo experiments indicated that the levels of LPS, TNF-α and IL-6 of the palmatine group were significantly lower than those of the sepsis model group (p<0.01). The group treated with palmatine showed strong neutralizing LPS activity in vivo. The palmatine group exhibited stronger protective activity on vital organs compared to the LPS-induced animal model. This verifies that HJD is a viable treatment option for sepsis given that there are multiple components in HJD that neutralize LPS, decrease the release of IL-6 and TNF-α induced by LPS, and protect vital organs.
[Mh] Termos MeSH primário: Alcaloides de Berberina/uso terapêutico
Medicamentos de Ervas Chinesas/uso terapêutico
Sepse/terapia
[Mh] Termos MeSH secundário: Animais
Alcaloides de Berberina/química
Modelos Animais de Doenças
Medicamentos de Ervas Chinesas/química
Regulação da Expressão Gênica
Seres Humanos
Interleucina-6/genética
Interleucina-6/metabolismo
Lipídeo A/metabolismo
Lipopolissacarídeos/imunologia
Camundongos
Camundongos Endogâmicos BALB C
Células RAW 264.7
Receptor 4 Toll-Like/genética
Receptor 4 Toll-Like/metabolismo
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (Drugs, Chinese Herbal); 0 (Interleukin-6); 0 (Lipid A); 0 (Lipopolysaccharides); 0 (Tlr4 protein, mouse); 0 (Toll-Like Receptor 4); 0 (Tumor Necrosis Factor-alpha); 0 (huanglian jiedu); G50C034217 (palmatine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


  8 / 1360 MEDLINE  
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[PMID]:28257954
[Au] Autor:Wang D; Wang K; Sui D; Ouyang Z; Xu H; Wei Y
[Ad] Endereço:School of Food and Biological Engineering, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
[Ti] Título:Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice.
[So] Source:Chem Biol Interact;268:47-52, 2017 Apr 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to investigate the effects of tetrahydroberberine (THB) and tetrahydropalmatine (THP) on the expression of mouse liver cytochrome P450s, and evaluate their liver toxicity in mice. Real-time polymerase chain reaction (PCR) and western blot analyses were used to analyze the expression of major P450 isoforms. Liver toxicity was evaluated by measuring serum biochemical parameters and performing histopathological analysis. The real-time PCR results showed that THB induced Cyp1a2 (1.66 ± 0.34 fold, P < 0.05), Cyp3a11 (1.57 ± 0.24 fold, P < 0.05), and Cyp2e1 (1.75 ± 0.97 fold, P < 0.05) mRNA expression, while THP inhibited Cyp1a2 (0.66 ± 0.12 fold, P < 0.05) mRNA expression. The western blot results confirmed that the expression of CYP1A2, CYP3A, and CYP2E1 proteins in the mouse liver was induced by THB, whereas that of CYP1A2 was inhibited by THP. Toxicological studies showed that THB (40 mg/kg, oral gavage) increased mouse serum aspartate transaminase and total bilirubin, and liver malondialdehyde levels, and induced liver edema. No obvious changes in serum and liver tissue biochemical parameters were found and no significant pathological changes were detected in liver tissues after THP administration. Our results provide more information on the toxicity of THB and THP, and their related drug-drug interactions.
[Mh] Termos MeSH primário: Alcaloides de Berberina/toxicidade
Berberina/análogos & derivados
Citocromo P-450 CYP1A2/metabolismo
Citocromo P-450 CYP2E1/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
[Mh] Termos MeSH secundário: Animais
Aspartato Aminotransferases/sangue
Berberina/toxicidade
Bilirrubina/sangue
Glutationa/metabolismo
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Malondialdeído/metabolismo
Camundongos Endogâmicos C57BL
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (RNA, Messenger); 0I8Y3P32UF (Berberine); 3X69CO5I79 (tetrahydropalmatine); 4Y8F71G49Q (Malondialdehyde); 9035-51-2 (Cytochrome P-450 Enzyme System); EC 1.14.13.- (Cytochrome P-450 CYP2E1); EC 1.14.13.- (cytochrome P-450 2E1, mouse); EC 1.14.14.1 (CYP3A protein, mouse); EC 1.14.14.1 (Cytochrome P-450 CYP1A2); EC 1.14.14.1 (cytochrome P-450 1A2, mouse); EC 2.6.1.1 (Aspartate Aminotransferases); GAN16C9B8O (Glutathione); RFM9X3LJ49 (Bilirubin); V2SSH085X8 (canadine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE


  9 / 1360 MEDLINE  
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[PMID]:28236763
[Au] Autor:Yan B; Wang D; Dong S; Cheng Z; Na L; Sang M; Yang H; Yang Z; Zhang S; Yan Z
[Ad] Endereço:Lanzhou Institute of Animal Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China. Electronic address: m15624955865@163.com.
[Ti] Título:Palmatine inhibits TRIF-dependent NF-κB pathway against inflammation induced by LPS in goat endometrial epithelial cells.
[So] Source:Int Immunopharmacol;45:194-200, 2017 Apr.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Palmatine, a natural pharmaceutical drug, possesses many biological activities. But its clinical application is rarely reported in the veterinary medicine. The aim of this study was to investigate the anti-inflammatory effects of palmatine on lipopolysaccharide (LPS)-induced inflammation in goat endometrial epithelial cells (gEECs), and the possible molecular mechanisms. Palmatine cell toxicity was determined by MTT assay, and the production of inflammatory cytokine in the cultured medium was measured with ELISA, qRT-PCR and Western blotting. Our results showed that palmatine treatment inhibited the release of tumor necrosis factor (TNF)-α, interleukin (IL)-1ß, IL-6, nitric oxide (NO), matrix metalloproteinase (MMP)-9 and MMP-2. Furthermore, palmatine enhanced the secretion of prostaglandins E (PGE ) and IL-10. Palmatine significantly down-regulated the expression of Toll-like receptor 4 (TLR4), cluster of differentiation 14 (CD14), Toll/interleukin 1 receptor (TIR)-domain-containing adaptor protein inducing interferon-ß (TICAM, TRIF) and nuclear factor-κB (NF-κB) in LPS stimulated gEECs, but did not alter the production of MyD88. In conclusion, palmatine inhibits TRIF-dependent NF-κB pathway to reduce LPS-induced inflammatory responses in goat endometrial epithelial cells.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transporte Vesicular/metabolismo
Anti-Inflamatórios/farmacologia
Alcaloides de Berberina/farmacologia
Endométrio/patologia
Células Epiteliais/efeitos dos fármacos
Inflamação/tratamento farmacológico
Macrófagos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Células Cultivadas
Citocinas/metabolismo
Regulação para Baixo
Células Epiteliais/imunologia
Feminino
Cabras
Lipopolissacarídeos/farmacologia
Macrófagos/imunologia
NF-kappa B/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Vesicular Transport); 0 (Anti-Inflammatory Agents); 0 (Berberine Alkaloids); 0 (Cytokines); 0 (Lipopolysaccharides); 0 (NF-kappa B); G50C034217 (palmatine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170226
[St] Status:MEDLINE


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[PMID]:28214075
[Au] Autor:Lee DYW; Liu J; Zhang S; Huang P; Liu-Chen LY
[Ad] Endereço:Bio-Organic and Natural Products Laboratory, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. Electronic address: DLee@mclean.harvard.edu.
[Ti] Título:Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.
[So] Source:Bioorg Med Chem Lett;27(6):1437-1440, 2017 03 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cocaine addiction remains a serious challenge for clinical and medical research because there is no effective pharmacological treatment. l-THP, a natural product isolated from Corydalis yanhusuo W.T. Wang, is one of the most frequently used traditional herbs to treat drug addiction in China. Our laboratory first reported that its demethylated metabolites l-ICP, l-CD, and l-CP had high affinity at dopamine D1, D2, and D5 receptors. Here we report the chemical synthesis of these metabolites and other derivatives and their binding affinities at dopamine receptors. The synthesis of these bioactive metabolites will allow further in vivo study of their potential in treating cocaine addiction.
[Mh] Termos MeSH primário: Alcaloides de Berberina/síntese química
Receptores Dopaminérgicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Alcaloides de Berberina/metabolismo
Sítios de Ligação
Seres Humanos
Ensaio Radioligante
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (Receptors, Dopamine); 728C74FB5Z (berbine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE



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