Base de dados : MEDLINE
Pesquisa : D03.132.098.666 [Categoria DeCS]
Referências encontradas : 5269 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 527 ir para página                         

  1 / 5269 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29390477
[Au] Autor:Xue XC; Qi XX; Wan XY
[Ad] Endereço:Department of Gastroenterology, The People's Hospital of Yan'an.
[Ti] Título:Randomized controlled study of efficacy and safety of drotaverine hydrochloride in patients with irritable bowel syndrome.
[So] Source:Medicine (Baltimore);96(51):e9235, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: This study aimed to assess the efficacy and safety of drotaverine hydrochloride (DHC) in Chinese patients with irritable bowel syndrome (IBS). METHODS: Totally, 144 patients with IBS were included and randomly divided into treatment group and placebo group in a 1:1 ratio. Patients received either DHC or placebo 80-mg tablet, 3 times daily for a total of 4 weeks. The primary outcome included abdominal pain, measured by the visual analog scale (VAS), and weekly stool frequency. The secondary outcomes were measured by the Bristol scale, and the 36-item short form health survey (SF-36), as well as the adverse events recorded during the treatment period. All those outcomes were measured at the end of 4-week treatment. RESULTS: The total and different types of IBS in VAS, stool frequency, and Bristol score were significantly better in the treatment group than those in the placebo group at the end of 4-week treatment. However, no significant difference was found in quality of life, measured by SF-36 scale between 2 groups. Additionally, no serious and significant differences in adverse events were found in and between both groups. CONCLUSION: The findings suggest that DHC has promising efficacy to enhance symptoms of IBS in Chinese population.
[Mh] Termos MeSH primário: Síndrome do Intestino Irritável/diagnóstico
Síndrome do Intestino Irritável/tratamento farmacológico
Papaverina/análogos & derivados
Segurança do Paciente
[Mh] Termos MeSH secundário: Administração Oral
Adulto
Idoso
Distribuição de Qui-Quadrado
China
Relação Dose-Resposta a Droga
Esquema de Medicação
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Papaverina/uso terapêutico
Medição de Risco
Índice de Gravidade de Doença
Método Simples-Cego
Estatísticas não Paramétricas
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
98QS4N58TW (drotaverin); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009235


  2 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
[PMID]:28832798
[Au] Autor:Huseyin S; Guclu O; Yüksel V; Erkul GSA; Can N; Turan FN; Canbaz S
[Ad] Endereço:Department of Cardiovascular Surgery of Trakya University School of Medicine, Edirne, Turkey.
[Ti] Título:Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study.
[So] Source:Braz J Cardiovasc Surg;32(3):197-201, 2017 May-Jun.
[Is] ISSN:1678-9741
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Objective:: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods:: 32 Sprague-Dawley female rats were randomized into four groups (n=8). Ischemia was induced with infrarenal aortic cross-clamping for 60 minutes; then the clamp was removed and reperfusion was allowed for 120 minutes. While the control group and the ischemia-reperfusion group did not receive any supplementary agent, two other groups received vitamin C and papaverine hydrochloride (papaverine HCL). Liver tissues were evaluated under the light microscope. Histopathological examination was assessed by Suzuki's criteria and results were compared between groups. Results:: In ischemia-reperfusion group, severe congestion, severe cytoplasmic vacuolization, and parenchymal necrosis over 60% (score 4) were observed. In vitamin C group, mild congestion, mild cytoplasmic vacuolization and parenchymal necrosis below 30% (score 2) were found. In papaverine group, moderate congestion, moderate cytoplasmic vacuolization and parenchymal necrosis below 60% (score 3) were observed. Conclusion:: An ischemia of 60 minutes induced on lower extremities causes damaging effects on hepatic tissue. Vitamin C and papaverine are helpful in reducing liver injury after acute ischemia reperfusion and may partially avoid related negative conditions.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Ácido Ascórbico/farmacologia
Fígado/irrigação sanguínea
Fígado/efeitos dos fármacos
Papaverina/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Aorta Abdominal
Ácido Ascórbico/uso terapêutico
Constrição
Modelos Animais de Doenças
Feminino
Fígado/patologia
Necrose
Papaverina/uso terapêutico
Distribuição Aleatória
Ratos Sprague-Dawley
Traumatismo por Reperfusão/patologia
Reprodutibilidade dos Testes
Fatores de Tempo
Resultado do Tratamento
Vasodilatadores/uso terapêutico
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Vasodilator Agents); DAA13NKG2Q (Papaverine); PQ6CK8PD0R (Ascorbic Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE


  3 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28609350
[Au] Autor:Zhu H; Zhu X; Zheng X
[Ad] Endereço:Shanghai, People's Republic of China From the Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital.
[Ti] Título:Antithrombotic Therapies in Digit Replantation with Papaverine Administration: A Prospective, Observational Study.
[So] Source:Plast Reconstr Surg;140(4):743-746, 2017 Oct.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The primary objective of this study was to investigate whether the application of antithrombotic therapies affects the success rate of digit replantation. METHODS: A total 477 digits of 319 patients who received dextran with low-molecular-weight heparin, dextran with prostaglandin E1, or no antithrombotic therapy after replantation of complete amputated digits from January 1, 2012, to January 1, 2016, were included in this study. Papaverine was given by intramuscular injection to all patients at a dosage of 90 mg/day postoperatively. RESULTS: There was no significant difference in any of the potential risk factors, including age, smoking, Tamai level of amputation, causes of injury, and warm ischemia time among groups. The survival rates of digits from patients who received dextran with low-molecular-weight heparin, dextran with prostaglandin E1, or no antithrombotic therapy were not significantly different. CONCLUSION: Antithrombotic therapies showed no significant benefit for digit replantation in patients receiving papaverine. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
[Mh] Termos MeSH primário: Amputação Traumática/cirurgia
Traumatismos dos Dedos/cirurgia
Papaverina/administração & dosagem
Complicações Pós-Operatórias/prevenção & controle
Reimplante/métodos
Terapia Trombolítica/métodos
Trombose/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Traumatismos dos Dedos/tratamento farmacológico
Seguimentos
Seres Humanos
Injeções Intramusculares
Masculino
Meia-Idade
Inibidores de Fosfodiesterase/administração & dosagem
Estudos Prospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Phosphodiesterase Inhibitors); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003665


  4 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28381739
[Au] Autor:Shiode N; Okimoto T; Tamekiyo H; Kawase T; Yamane K; Kagawa Y; Fujii Y; Ueda Y; Hironobe N; Kato Y; Hayashi Y
[Ad] Endereço:Department of Cardiology, Hiroshima City Hiroshima Citizens Hospital, Japan.
[Ti] Título:A Comparison between the Instantaneous Wave-free Ratio and Resting Distal Coronary Artery Pressure/Aortic Pressure and the Fractional Flow Reserve: The Diagnostic Accuracy Can Be Improved by the Use of both Indices.
[So] Source:Intern Med;56(7):749-753, 2017.
[Is] ISSN:1349-7235
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Objectives The fractional flow reserve (FFR) is an index of the severity of coronary stenosis that has been clinically validated in several studies. The instantaneous wave-free ratio (iFR) and the resting distal coronary artery pressure/aortic pressure (Pd/Pa) are nonhyperemic pressure-derived indices of the severity of stenosis. This study sought to examine the diagnostic accuracy of the iFR and resting Pd/Pa with respect to hyperemic FFR. Methods Following an intracoronary injection of papaverine, the iFR, resting Pd/Pa, and FFR were continuously measured in 123 lesions in 103 patients with stable coronary disease. Results The iFR and resting Pd/Pa values were strongly correlated with the FFR (R=0.794, p<0.001, R=0.832, p<0.0001, respectively). A receiver operator curve (ROC) analysis revealed that the optimal iFR cut-off value for predicting an FFR of <0.80 was 0.89 (AUC 0.901, sensitivity 84.1%, specificity 80.0%, positive predictive value 69.8%, negative predictive value 90.0%, diagnostic accuracy 81.3%), while the optimal resting Pd/Pa cut-off value was 0.92 (AUC 0.925, sensitivity 90.9%, specificity 78.5%, positive predictive value 70.2%, negative predictive value 93.9%, diagnostic accuracy 82.9%). The lesions with an iFR value of ≤0.89 and a Pd/Pa value of ≤0.92 were defined as double-positive lesions, while the lesions with an iFR value of >0.89 and a Pd/Pa value of >0.92 were defined as double-negative lesions. In these 109 lesions, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 92.3%, 82.9%, 75.0%, 95.1%, and 86.2%, respectively. Conclusion This analysis demonstrated that the iFR and resting Pd/Pa were strongly correlated with the FFR and that the diagnostic accuracy of the iFR was similar to that of the resting Pd/Pa. The diagnostic accuracy can be improved with the use of both the iFR and the resting Pd/Pa.
[Mh] Termos MeSH primário: Aorta/fisiologia
Pressão Arterial/fisiologia
Estenose Coronária/diagnóstico
Reserva Fracionada de Fluxo Miocárdico/fisiologia
[Mh] Termos MeSH secundário: Idoso
Angiografia Coronária
Doença da Artéria Coronariana
Feminino
Coração
Seres Humanos
Hiperemia/fisiopatologia
Masculino
Meia-Idade
Papaverina/farmacologia
Sensibilidade e Especificidade
Índice de Gravidade de Doença
Vasodilatadores/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Vasodilator Agents); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170609
[Lr] Data última revisão:
170609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.2169/internalmedicine.56.7857


  5 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28381364
[Au] Autor:Slampová A; Kubán P
[Ad] Endereço:Institute of Analytical Chemistry of the Czech Academy of Sciences, v. v. i., Veverí 97, CZ-60200 Brno, Czech Republic.
[Ti] Título:Injections from sub-µL sample volumes in commercial capillary electrophoresis.
[So] Source:J Chromatogr A;1497:164-171, 2017 May 12.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A simple sample injection procedure compatible with commercial capillary electrophoresis (CE) instrumentation was developed, which enables handling sample volumes as little as 250nL for analytical applications where sample volume availability is of concern. Single-use micro-sampling inserts were prepared by thermal modification of polypropylene micropipette tips and the inserts were accommodated in standard CE vials in CE autosampler carousel. To ensure direct contact of separation capillary injection end with sample solution and to avoid possible damage to the capillary, a soft compression spring was placed at the bottom of the vial underneath the micro-sampling insert. Injections from sub-µL samples were carried out in conventional as well as in short-end injection mode, were compatible with standard i.d./o.d. (25-100µm/365µm) fused silica capillaries and with various background electrolyte solutions and detection modes. Excellent repeatability of replicate injections from 250nL to 3µL was achieved based on RSD values of quantitative analytical measures (peak heights ≤2.4% and peak areas ≤3.7%) for CE-UV-vis, CE-ESI-MS and CE-contactless conductivity detection of model basic drugs. The achieved RSD values were comparable with those for replicate injections of the drugs from standard CE vials. The reported concept of injections from micro-sampling inserts was further demonstrated useful in evaluation of micro-electromembrane extraction (µ-EME) of model basic drugs. Sub-µL volumes of operational solutions resulted in reduced lengths of µ-EME phases and improved extraction recoveries (66-91%) were achieved.
[Mh] Termos MeSH primário: Eletroforese Capilar/métodos
[Mh] Termos MeSH secundário: Eletrólitos/química
Eletroforese Capilar/instrumentação
Espectrometria de Massas
Nortriptilina/análise
Nortriptilina/isolamento & purificação
Papaverina/análise
Soluções/química
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Electrolytes); 0 (Solutions); BL03SY4LXB (Nortriptyline); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE


  6 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28366471
[Au] Autor:Vogel EW; Morales FN; Meaney DF; Bass CR; Morrison B
[Ad] Endereço:Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
[Ti] Título:Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast.
[So] Source:Exp Neurol;293:91-100, 2017 Jul.
[Is] ISSN:1090-2430
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Due to recent military conflicts and terrorist attacks, blast-induced traumatic brain injury (bTBI) presents a health concern for military and civilian personnel alike. Although secondary blast (penetrating injury) and tertiary blast (inertia-driven brain deformation) are known to be injurious, the effects of primary blast caused by the supersonic shock wave interacting with the skull and brain remain debated. Our group previously reported that in vitro primary blast exposure reduced long-term potentiation (LTP), the electrophysiological correlate of learning and memory, in rat organotypic hippocampal slice cultures (OHSCs) and that primary blast affects key proteins governing LTP. Recent studies have investigated phosphodiesterase-4 (PDE4) inhibition as a therapeutic strategy for reducing LTP deficits following inertia-driven TBI. We investigated the therapeutic potential of PDE4 inhibitors, specifically roflumilast, to ameliorate primary blast-induced deficits in LTP. We found that roflumilast at concentrations of 1nM or greater prevented deficits in neuronal plasticity measured 24h post-injury. We also observed a therapeutic window of at least 6h, but <23h. Additionally, we investigated molecular mechanisms that could elucidate this therapeutic effect. Roflumilast treatment (1nM delivered 6h post-injury) significantly increased total AMPA glutamate receptor 1 (GluR1) subunit expression, phosphorylation of the GluR1 subunit at the serine-831 site, and phosphorylation of stargazin at the serine-239/240 site upon LTP induction, measured 24h following injury. Roflumilast treatment significantly increased PSD-95 regardless of LTP induction. These findings indicate that further investigation into the translation of PDE4 inhibition as a therapy following bTBI is warranted.
[Mh] Termos MeSH primário: Traumatismos por Explosões/patologia
Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/metabolismo
Hipocampo/fisiologia
Potenciação de Longa Duração/fisiologia
[Mh] Termos MeSH secundário: Aminopiridinas/uso terapêutico
Animais
Animais Recém-Nascidos
Benzamidas/uso terapêutico
Morte Celular
Ciclopropanos/uso terapêutico
Modelos Animais de Doenças
Proteína 4 Homóloga a Disks-Large
Regulação da Expressão Gênica/efeitos dos fármacos
Glicina/farmacologia
Guanilato Quinases/metabolismo
Hipocampo/efeitos dos fármacos
Técnicas In Vitro
Potenciação de Longa Duração/efeitos dos fármacos
Proteínas de Membrana/metabolismo
Papaverina/farmacologia
Papaverina/uso terapêutico
Inibidores da Fosfodiesterase 4/farmacologia
Inibidores da Fosfodiesterase 4/uso terapêutico
Piridinas/farmacologia
Piridinas/uso terapêutico
Ratos
Ratos Sprague-Dawley
Receptores de AMPA/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminopyridines); 0 (Benzamides); 0 (Cyclopropanes); 0 (Disks Large Homolog 4 Protein); 0 (Dlg4 protein, mouse); 0 (Membrane Proteins); 0 (Phosphodiesterase 4 Inhibitors); 0 (Pyridines); 0 (Receptors, AMPA); 0 (glutamate receptor ionotropic, AMPA 1); 0P6C6ZOP5U (Roflumilast); DAA13NKG2Q (Papaverine); EC 2.7.4.8 (Guanylate Kinases); EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 4); M0TTH61XC5 (ibudilast); TE7660XO1C (Glycine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE


  7 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:28365943
[Au] Autor:Huang H; Li LJ; Zhang HB; Wei AY
[Ad] Endereço:Graduate School, Southern Medical University, Guangzhou, China.
[Ti] Título:Papaverine selectively inhibits human prostate cancer cell (PC-3) growth by inducing mitochondrial mediated apoptosis, cell cycle arrest and downregulation of NF-κB/PI3K/Akt signalling pathway.
[So] Source:J BUON;22(1):112-118, 2017 Jan-Feb.
[Is] ISSN:1107-0625
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The main objective of the current research work was to investigate the antitumor effects of papaverine in PC-3 human prostate cancer cells along with testing its toxicity in the normal human fibroblast (NHF) cells. METHODS: The cytotoxic effects of papaverine were examined by the MTT cell viability assay. Flow cytometry using annexin V-FITC/PI was used to study the effects on apoptosis, including its quantification. Effects on cell cycle progression were analyzed by flow cytometry while as effects on apoptosis-related proteins, NF-kB and PI3K/Akt pathways were estimated by Western blot assay. RESULTS: The results indicated that papaverine could induce significant, highly selective and dose-dependent cytotoxic effects in PC-3 cells without causing too much toxicity in normal cells. Papaverine also led to induction of early and late apoptosis along with inducing sub-G1 cell cycle arrest in a dose-dependent manner. Papaverine induced a dose-dependent reduction in the expression levels of Blc-2 proteins and a dose-dependent increase in the expression levels of Bax protein. The expression levels of NF-kB were decreased markedly in comparison to the untreated control. Papaverine treatment also led to a dose-dependent downregulation of PI3K and phospho-Akt expression. CONCLUSION: Papaverine showed selective antitumor properties against PC-3 human prostate cancer cells by inducing early and late apoptosis, sub-G1 cell cycle arrest, modulation of apoptosis-related proteins like Bcl-2, Bax, Bid, XIAP and cytochrome C along with downregulation of NFkB, PI3K/Akt signalling pathway.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Mitocôndrias/fisiologia
NF-kappa B/fisiologia
Fosfatidilinositol 3-Quinases/fisiologia
Neoplasias da Próstata/tratamento farmacológico
Proteínas Proto-Oncogênicas c-akt/fisiologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Regulação para Baixo
Seres Humanos
Masculino
Papaverina
Neoplasias da Próstata/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); DAA13NKG2Q (Papaverine); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170403
[St] Status:MEDLINE


  8 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28272280
[Au] Autor:Di Lorenzo S; Corradino B; Cordova A
[Ad] Endereço:Discipline Chirurgiche, Oncologiche e Stomatologiche, Università di Palermo, Palermo, Italy, dilsister@libero.it.
[Ti] Título:Comparing the Outcomes of Different Agents to Treat Vasospasm at Microsurgical Anastomosis during the Papaverine Shortage.
[So] Source:Plast Reconstr Surg;140(1):229e, 2017 07.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Papaverina
Vasoconstrição
[Mh] Termos MeSH secundário: Seres Humanos
Doenças Vasculares
Vasodilatadores
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Vasodilator Agents); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003451


  9 / 5269 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28272278
[Au] Autor:Ricci J; Lin SJ
[Ad] Endereço:Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass.
[Ti] Título:Reply: Comparing the Outcomes of Different Agents to Treat Vasospasm at Microsurgical Anastomosis during the Papaverine Shortage.
[So] Source:Plast Reconstr Surg;140(1):229e-231e, 2017 07.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Papaverina
Vasoconstrição
[Mh] Termos MeSH secundário: Seres Humanos
Doenças Vasculares
Vasodilatadores
[Pt] Tipo de publicação:LETTER; COMMENT
[Nm] Nome de substância:
0 (Vasodilator Agents); DAA13NKG2Q (Papaverine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003453


  10 / 5269 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28259094
[Au] Autor:Kazsoki A; Szabó P; Zelkó R
[Ad] Endereço:University Pharmacy Department of Pharmacy Administration, Semmelweis University, Hogyes Endre St. 7-9, H-1092 Budapest, Hungary.
[Ti] Título:Prediction of the hydroxypropyl cellulose-poly(vinyl alcohol) ratio in aqueous solution containing papaverine hydrochloride in terms of drug loaded electrospun fiber formation.
[So] Source:J Pharm Biomed Anal;138:357-362, 2017 May 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Papaverine hydrochloride loaded electrospun fibers were prepared for buccal drug delivery with the aim of improving the oral bioavailability of the crystalline drug, which can be achieved by the increased solubility and by the circumvention of the intensive first pass metabolism. The water soluble hydroxypropyl cellulose (HPC) was chosen as a mucoadhesive polymer. In order to improve the electrospinnability of HPC, the also mucoadhesive poly(vinyl alcohol) (PVA) was used. During the experiments, the total polymer concentration was kept constantly at 15% (w/w), and only the ratio of the two polymers was changed. Five different HPC:PVA ratios (5:5, 6:4, 7:3, 8:2, 9:1) were examined. Combination of rheological measurements and molar reflectance characterization with scanning electron microscopy was applied for the determination of the optimum composition of the gels for fiber formation. The crystalline-amorphous transition of papaverine hydrochloride was also tracked by Fourier transform infrared spectroscopy. A correlation was found between the macrostructural properties of the polymer solutions and their electrospinnability and the consequent morphology of the resultant samples. Along with the changes of the polymer ratio, the corresponding morphology of the electrospun samples also varied. With decreasing HPC ratio of the system, a transition from the spray-dried film-like structure through fibrous film to fibers was observed. Polymer solutions of the lowest elasticity and smallest intermolecular interactions contributed to the best fiber characteristics of the samples. The results enable the determination of the polymer ratio for the formation of applicable quality of electrospun fibers. According to the results 5:5 and 6:4 polymer ratios enabled the best fiber performance.
[Mh] Termos MeSH primário: Celulose/análogos & derivados
Papaverina/química
Polímeros/química
Cloreto de Polivinila/química
Soluções/química
Água/química
[Mh] Termos MeSH secundário: Celulose/química
Sistemas de Liberação de Medicamentos/métodos
Microscopia Eletrônica de Varredura/métodos
Solubilidade
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polymers); 0 (Solutions); 059QF0KO0R (Water); 9002-86-2 (Polyvinyl Chloride); 9004-34-6 (Cellulose); DAA13NKG2Q (Papaverine); RFW2ET671P (hydroxypropylcellulose)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE



página 1 de 527 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde