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[PMID]:29427588
[Au] Autor:Nishimura-Danjobara Y; Oyama K; Yokoigawa K; Oyama Y
[Ad] Endereço:Department of Food Science, Faculty of Bioscience and Bioindustry, Tokushima University, Tokushima 770-8513, Japan.
[Ti] Título:Hyperpolarization by N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes.
[So] Source:Chem Biol Interact;283:91-96, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:To study the adverse effects of N-(3-oxododecanoyl)-l-homoserine-lactone (ODHL), a quorum sensing molecule, on mammalian host cells, its effect on membrane potential was examined in rat thymic lymphocytes using flow cytometric techniques with a voltage-sensitive fluorescent probe. As 3-300 µM ODHL elicited hyperpolarization, it is likely that it increases membrane K permeability because hyperpolarization is directly linked to changing K gradient across membranes, but not Na and Cl gradients. ODHL did not increase intracellular Ca concentration. ODHL also produced a response in the presence of an intracellular Zn chelator. Thus, it is unlikely that intracellular Ca and Zn are attributed to the response. Quinine, a non-specific K channel blocker, greatly reduced hyperpolarization. However, because charybdotoxin, tetraethylammonium chloride, 4-aminopyridine, and glibenclamide did not affect it, it is pharmacologically hypothesized that Ca -activated K channels, voltage-gated K channels, and ATP-sensitive K channels are not involved in ODHL-induced hyperpolarization. Although the K channels responsible for ODHL-induced hyperpolarization have not been identified, it is suggested that ODHL can elicit hyperpolarization in mammalian host cells, disturbing cellular functions.
[Mh] Termos MeSH primário: 4-Butirolactona/análogos & derivados
Polaridade Celular/efeitos dos fármacos
Homosserina/análogos & derivados
Percepção de Quorum/efeitos dos fármacos
[Mh] Termos MeSH secundário: 4-Butirolactona/farmacologia
Animais
Cálcio/metabolismo
Charibdotoxina/farmacologia
Citometria de Fluxo
Glibureto/farmacologia
Homosserina/farmacologia
Canais KATP/metabolismo
Linfócitos/citologia
Linfócitos/efeitos dos fármacos
Linfócitos/metabolismo
Permeabilidade/efeitos dos fármacos
Potássio/metabolismo
Canais de Potássio de Abertura Dependente da Tensão da Membrana/metabolismo
Quinina/farmacologia
Ratos
Ratos Wistar
Timócitos/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (KATP Channels); 0 (N-(3-oxododecanoyl)homoserine lactone); 0 (Potassium Channels, Voltage-Gated); 115422-61-2 (Charybdotoxin); 6KA95X0IVO (Homoserine); A7V27PHC7A (Quinine); OL659KIY4X (4-Butyrolactone); RWP5GA015D (Potassium); SX6K58TVWC (Glyburide); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180211
[St] Status:MEDLINE


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[PMID]:27773233
[Au] Autor:Kaur K; Kumar R; Arpita; Goel S; Uppal S; Bhatia A; Mehta SK
[Ad] Endereço:Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160 014, India. Electronic address: makkarkhushi@gmail.com.
[Ti] Título:Physiochemical and cytotoxicity study of TPGS stabilized nanoemulsion designed by ultrasonication method.
[So] Source:Ultrason Sonochem;34:173-182, 2017 01.
[Is] ISSN:1873-2828
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The main aim of the present work was to prepare TPGS stabilized D-α-Tocopherol, lemon oil, tween-80, and water nanoemulsion by low cost and highly effective sonication method. The prepared nanoemulsion showed good stability for 60days at variable temperature conditions i.e. 4, 25 and 37°C. The tolerance of the prepared nanoemulsion to salt (50mM-500mM) and pH (pH 2-pH 7.4) was also studied. The morphology and droplet size of pure and quinine loaded nanoemulsion was characterized with transmission electron microscopy. The prepared formulation was transparent and the obtained average particle size ranged between 25nm and 35nm. The nanoemulsion was found to be non toxic. The cell viability study of pure nanoemulsion carried out on Hep G2 cells revealed that the cell viability was 100%. The formulation further exhibited high quinine loading and release capacity with cumulative release up to 76±2% and 65±2% at pH 7.4 and pH 5.5 respectively. The interaction between quinine and vitamins (riboflavin, thiamine and biotin) was also carried out (aqueous medium). The study revealed that riboflavin had strong interaction with quinine and vitamins vis-à-vis thiamine and biotin.
[Mh] Termos MeSH primário: Antineoplásicos/química
Antineoplásicos/farmacologia
Fenômenos Químicos
Portadores de Fármacos/química
Nanoestruturas/química
Sonicação
Vitamina E/química
[Mh] Termos MeSH secundário: Sobrevivência Celular/efeitos dos fármacos
Liberação Controlada de Fármacos
Emulsões
Células Hep G2
Seres Humanos
Tamanho da Partícula
Quinina/química
Quinina/farmacologia
Tensoativos/química
Vitaminas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Drug Carriers); 0 (Emulsions); 0 (Surface-Active Agents); 0 (Vitamins); 1406-18-4 (Vitamin E); A7V27PHC7A (Quinine); O03S90U1F2 (tocophersolan)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180131
[Lr] Data última revisão:
180131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:28979626
[Au] Autor:Nanfack CN; Bilong Y; Kagmeni G; Nathan NN; Bella LA
[Ad] Endereço:Ophthalmology Unit, Pediatric and Gynéco-Obstetric Hospital, Yaoundé, Cameroon.
[Ti] Título:Malarial retinopathy in adult: a case report.
[So] Source:Pan Afr Med J;27:224, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Although widely reported in children, the malarial retinopathy has rarely been described in adults. We observed a case in the department of ophthalmology at the pediatric and gynecology-obstetrics Yaoundé Hospital. The diagnosis revealing a decrease in visual acuity was confirmed by thorough ophthalmological and biological assessments. The basic treatment by was conclusive. The authors point out the need to consider this diagnosis in case of any decrease in visual acuity in febrile context for any adult living or recently having stayed in endemic areas.
[Mh] Termos MeSH primário: Antimaláricos/administração & dosagem
Malária Cerebral/diagnóstico
Quinina/administração & dosagem
Doenças Retinianas/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Camarões
Seres Humanos
Malária Cerebral/complicações
Malária Cerebral/tratamento farmacológico
Masculino
Doenças Retinianas/tratamento farmacológico
Doenças Retinianas/parasitologia
Acuidade Visual
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.224.11026


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[PMID]:28818049
[Au] Autor:Fanello C; Onyamboko M; Lee SJ; Woodrow C; Setaphan S; Chotivanich K; Buffet P; Jauréguiberry S; Rockett K; Stepniewska K; Day NPJ; White NJ; Dondorp AM
[Ad] Endereço:Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. caterina@tropmedres.ac.
[Ti] Título:Post-treatment haemolysis in African children with hyperparasitaemic falciparum malaria; a randomized comparison of artesunate and quinine.
[So] Source:BMC Infect Dis;17(1):575, 2017 Aug 17.
[Is] ISSN:1471-2334
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parenteral artesunate is the treatment of choice for severe malaria. Recently, haemolytic anaemia occurring 1 to 3 weeks after artesunate treatment of falciparum malaria has been reported in returning travellers in temperate countries. METHODS: To assess these potential safety concerns in African children, in whom most deaths from malaria occur, an open-labelled, randomized controlled trial was conducted in Kinshasa, Democratic Republic of Congo. 217 children aged between 6 months and 14 years with acute uncomplicated falciparum malaria and parasite densities over 100,000/µL were randomly allocated to intravenous artesunate or quinine, hospitalized for 3 days and then followed for 42 days. RESULTS: The immediate reduction in haemoglobin was less with artesunate than with quinine: median (IQR) fall at 72 h 1.4 g/dL (0.90-1.95) vs. 1.7 g/dL (1.10-2.40) (p = 0.009). This was explained by greater pitting then recirculation of once infected erythrocytes. Only 5% of patients (in both groups) had a ≥ 10% reduction in haemoglobin after day 7 (p = 0.1). One artesunate treated patient with suspected concomitant sepsis had a protracted clinical course and required a blood transfusion on day 14. CONCLUSIONS: Clinically significant delayed haemolysis following parenteral artesunate is uncommon in African children hospitalised with acute falciparum malaria and high parasitaemias. TRIAL REGISTRATION: ClinicalTrials.gov ; Identifier: NCT02092766 (18/03/2014).
[Mh] Termos MeSH primário: Anemia Hemolítica/induzido quimicamente
Antimaláricos/efeitos adversos
Artemisininas/efeitos adversos
Malária Falciparum/tratamento farmacológico
Quinina/efeitos adversos
[Mh] Termos MeSH secundário: Administração Intravenosa
Adolescente
Antimaláricos/uso terapêutico
Artemisininas/administração & dosagem
Artemisininas/uso terapêutico
Transfusão de Sangue
Criança
Pré-Escolar
República Democrática do Congo
Eritrócitos/efeitos dos fármacos
Eritrócitos/parasitologia
Feminino
Hemólise/efeitos dos fármacos
Hospitalização
Seres Humanos
Lactente
Masculino
Quinina/administração & dosagem
Quinina/uso terapêutico
Sepse/parasitologia
Sepse/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antimalarials); 0 (Artemisinins); 60W3249T9M (artesunate); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170819
[St] Status:MEDLINE
[do] DOI:10.1186/s12879-017-2678-0


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[PMID]:28780041
[Au] Autor:Page EE; Little DJ; Vesely SK; George JN
[Ad] Endereço:Department of Biostatistics and Epidemiology, College of Public Health, Oklahoma City, OK; Hematology-Oncology Section, Department of Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
[Ti] Título:Quinine-Induced Thrombotic Microangiopathy: A Report of 19 Patients.
[So] Source:Am J Kidney Dis;70(5):686-695, 2017 Nov.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Quinine can cause diverse and severe immune-mediated adverse reactions, including thrombotic microangiopathy (TMA). Our objective was to describe the presenting features and long-term outcomes of patients with quinine-induced TMA. STUDY DESIGN: A case series of 19 patients with quinine-induced TMA treated with plasma exchange. SETTING & PARTICIPANTS: Patients with quinine-induced TMA initially suspected of having thrombotic thrombocytopenic purpura (TTP) were identified among patients enrolled in the Oklahoma TTP-Hemolytic Uremic Syndrome Registry. OUTCOMES: The clinical course of the initial episode and morbidity and mortality following recovery. MEASUREMENTS: The diagnosis of quinine-induced TMA was confirmed by documentation of quinine-dependent antibodies reactive with platelets or neutrophils and/or by previous quinine-associated systemic symptoms. Clinical data from the initial episode and long-term follow-up were described, focusing on kidney function. RESULTS: 19 of the 509 patients enrolled in the registry in 1989 to 2015 had quinine-induced TMA. 18 patients had quinine-dependent antibodies reactive with platelets and/or neutrophils (1 patient died before testing); 8 patients had a history of quinine-associated systemic symptoms. All patients were white; 18 were women. Quinine exposure was in pill form for 18 patients and as tonic water for 1. All patients had microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. All were initially misdiagnosed as having TTP or hemolytic uremic syndrome, and adverse reactions to quinine were not initially suspected. 1 patient died before treatment began; 17 of the 18 surviving patients required dialysis. 14 patients developed chronic kidney disease, 3 of whom developed end-stage renal disease. 8 patients died. LIMITATIONS: Patients for whom plasma exchange was not requested were not identified. CONCLUSIONS: Quinine-induced TMA causes severe acute kidney injury that commonly results in chronic kidney disease.
[Mh] Termos MeSH primário: Lesão Renal Aguda/induzido quimicamente
Anemia Hemolítica/induzido quimicamente
Relaxantes Musculares Centrais/efeitos adversos
Quinina/efeitos adversos
Sistema de Registros
Trombocitopenia/induzido quimicamente
Microangiopatias Trombóticas/induzido quimicamente
[Mh] Termos MeSH secundário: Lesão Renal Aguda/terapia
Adulto
Idoso
Anemia Hemolítica/terapia
Feminino
Seres Humanos
Masculino
Meia-Idade
Oklahoma
Troca Plasmática
Diálise Renal
Trombocitopenia/terapia
Microangiopatias Trombóticas/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscle Relaxants, Central); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170807
[St] Status:MEDLINE


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[PMID]:28720326
[Au] Autor:Narhe BD; Breman AC; Padwal J; Vandenput DAL; Scheidt JM; Benningshof JCJ; van der Marel GA; Overkleeft HS; van der Stelt M; Filippov DV
[Ad] Endereço:Leiden Institute of Chemistry, Gorlaeus Laboratories, P. O. Box 9502, Universiteit Leiden, 2300 RA Leiden, The Netherlands.
[Ti] Título:Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory.
[So] Source:Bioorg Med Chem;25(19):5160-5170, 2017 Oct 01.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We report short and efficient scalable syntheses of enantiomerically pure (3R,4S)-3-(hydroxymethyl4-(hydroxyethyl))-piperidine and 1-hydroxymethyl-octahydro-1H-pyrano[3,4-c]pyridine scaffolds. The alkaloid core was readily synthesized from naturally occurring quinine and can serve as a valued starting point for drug-discovery. Cleavage of a terminal 1,2-diol and acid catalysed epoxide opening cyclization are the key steps involved. A number of members of a projected small-molecular library is synthesized for each scaffold.
[Mh] Termos MeSH primário: Piperidinas/química
Piridinas/química
Bibliotecas de Moléculas Pequenas/química
[Mh] Termos MeSH secundário: Amino Álcoois/síntese química
Amino Álcoois/química
Técnicas de Química Sintética/métodos
Descoberta de Drogas
Piperidinas/síntese química
Piridinas/síntese química
Quinina/análogos & derivados
Quinina/síntese química
Bibliotecas de Moléculas Pequenas/síntese química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Alcohols); 0 (Piperidines); 0 (Pyridines); 0 (Small Molecule Libraries); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE


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[PMID]:28554853
[Au] Autor:Antinori S; Corona A; Castelli A; Rech R; Borghi B; Giannotti C; Colombo R; Fossali T; Ballone E; Minari C; Perotti A; Bergomi P; Galimberti L; Milazzo L; Ricaboni D; Scorza D; Grande R; Genderini F; Ieri M; Raimondi F; Catena E; Galli M; Corbellino M
[Ad] Endereço:Department of Clinical and Biomedical Sciences Luigi Sacco, University of Milano, Italy; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milano, Italy. Electronic address: spinello.antinori@unimi.it.
[Ti] Título:Severe Plasmodium falciparum malaria in the intensive care unit: A 6-year experience in Milano, Italy.
[So] Source:Travel Med Infect Dis;17:43-49, 2017 May - Jun.
[Is] ISSN:1873-0442
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Severe imported Plasmodium falciparum malaria is a potentially life-threatening disease with a reported mortality rate of 5-10% when patients are admitted to the Intensive Care Unit. METHODS: To retrospectively review the clinical aspects, the value of severity predictive scores and the management of patients with severe P. falciparum malaria admitted to an ICU in Milano, Italy between January 2010 and December 2015. RESULTS: Twelve patients were included: seven were male and five female with a median age of 43 years. All were initially treated with intravenous quinine. Median parasitaemia upon admission was 14,5% (range 1-20%). At the time of ICU admission, 3 patients (25%) had 5 or more World Health Organization criteria for severe malaria while another 6 of them developed one or more of the latter during their stay in ICU. Five required mechanical ventilation because of respiratory failure due to ARDS. Four patients required renal replacement therapy. Three patients underwent blood exchange transfusion. All patients survived. CONCLUSIONS: Our retrospective evaluation of adults patients admitted to the ICU with severe imported P. falciparum malaria demonstrated a favourable outcome. Severity predictive scores currently in use probably overestimate the risk of malaria mortality in patients treated in health care systems of high income countries.
[Mh] Termos MeSH primário: Unidades de Terapia Intensiva
Malária Falciparum
[Mh] Termos MeSH secundário: Adulto
Antimaláricos/uso terapêutico
Feminino
Seres Humanos
Itália/epidemiologia
Malária Falciparum/diagnóstico
Malária Falciparum/tratamento farmacológico
Malária Falciparum/epidemiologia
Malária Falciparum/mortalidade
Masculino
Meia-Idade
Quinina/uso terapêutico
Estudos Retrospectivos
Viagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


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[PMID]:28531312
[Au] Autor:Armstrong JE; Laing DG; Jinks AL
[Ad] Endereço:Faculty of Medicine, School of Women and Children's Health, University of New South Wales, Level 3, Sydney Children's Hospital, High Street, Randwick, New South Wales 2031, Australia and.
[Ti] Título:Taste-Elicited Activity in Facial Muscle Regions in 5-8-Week-Old Infants.
[So] Source:Chem Senses;42(5):443-453, 2017 Jun 01.
[Is] ISSN:1464-3553
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The state of development of the sense of taste in humans during the first few months of life is only partially understood. Since taste plays a critical role in the feeding and nutrition of infants a better understanding of taste development during early life is required. Currently, information about the sense of taste in pre-verbal infants is obtained by analysis of videotaped facial expressions using the Baby FACS coding system. A potentially more objective faster procedure for assessing facial expressions not investigated in infants is electromyography (EMG). The method has been successfully used to study taste-elicited responses in the mid-face muscle regions of the levator labii and zygomaticus major of 6-9-year-olds and in a range of facial muscle regions in adults. Accordingly, this study aimed to investigate taste in young infants using EMG to 1) measure activity simultaneously in 4 facial muscle regions in response to 3 common tastants and 2) determine whether the activities of one or more muscle regions is needed to provide evidence of perception of a tastant by an infant. The results indicated that multiple facial muscle regions responded simultaneously but differentially to non-sweet and sweet tastants and recordings of activities from 3 or 4 regions simultaneously indicated that almost 100% of infants responded to the unpleasant tastes of quinine and citric acid, and 80% to sucrose.
[Mh] Termos MeSH primário: Músculos Faciais/efeitos dos fármacos
Músculos Faciais/fisiologia
Paladar/efeitos dos fármacos
Paladar/fisiologia
[Mh] Termos MeSH secundário: Ácido Cítrico/administração & dosagem
Ácido Cítrico/farmacologia
Eletromiografia
Feminino
Seres Humanos
Lactente
Masculino
Quinina/administração & dosagem
Quinina/farmacologia
Sacarose/administração & dosagem
Sacarose/farmacologia
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
2968PHW8QP (Citric Acid); 57-50-1 (Sucrose); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE
[do] DOI:10.1093/chemse/bjx023


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[PMID]:28513558
[Au] Autor:Cheled-Shoval S; Behrens M; Korb A; Di Pizio A; Meyerhof W; Uni Z; Niv MY
[Ad] Endereço:Department of Animal Science, The Robert H. Smith Faculty of Agriculture, Food, and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel. Shira.cheled@gmail.com.
[Ti] Título:From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds.
[So] Source:Molecules;22(5), 2017 May 17.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bitter taste elicits an aversive reaction, and is believed to protect against consuming poisons. Bitter molecules are detected by the Tas2r family of G-protein-coupled receptors, with a species-dependent number of subtypes. Chickens demonstrate bitter taste sensitivity despite having only three bitter taste receptors-ggTas2r1, ggTas2r2 and ggTas2r7. This minimalistic bitter taste system in chickens was used to determine relationships between in-vitro (measured in heterologous systems) and in-vivo (behavioral) detection thresholds. ggTas2r-selective ligands, nicotine (ggTas2r1), caffeine (ggTas2r2), erythromycin and (+)-catechin (ggTas2r7), and the Tas2r-promiscuous ligand quinine (all three ggTas2rs) were studied. Ligands of the same receptor had different in-vivo:in-vitro ratios, and the ggTas2r-promiscuous ligand did not exhibit lower in-vivo:in-vitro ratios than ggTas2r-selective ligands. In-vivo thresholds were similar or up to two orders of magnitude higher than the in-vitro ones.
[Mh] Termos MeSH primário: Galinhas/metabolismo
Receptores Acoplados a Proteínas-G/metabolismo
Limiar Gustativo
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva
Bico
Cafeína/química
Catequina/química
Eritromicina/química
Expressão Gênica
Células HEK293
Seres Humanos
Ligantes
Nicotina/química
Quinina/química
Receptores Acoplados a Proteínas-G/genética
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ligands); 0 (Receptors, G-Protein-Coupled); 3G6A5W338E (Caffeine); 63937KV33D (Erythromycin); 6M3C89ZY6R (Nicotine); 8R1V1STN48 (Catechin); A7V27PHC7A (Quinine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170518
[St] Status:MEDLINE


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[PMID]:28492890
[Au] Autor:Fardet L; Nazareth I; Petersen I
[Ad] Endereço:EA 7379 EpiDermE, Université Paris Est Créteil, Créteil, France.
[Ti] Título:Association Between Long-term Quinine Exposure and All-Cause Mortality.
[So] Source:JAMA;317(18):1907-1909, 2017 05 09.
[Is] ISSN:1538-3598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Mortalidade
Cãibra Muscular/tratamento farmacológico
Quinina/efeitos adversos
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Causas de Morte
Feminino
Seguimentos
Parada Cardíaca/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Quinina/administração & dosagem
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
A7V27PHC7A (Quinine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1001/jama.2017.2332



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