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Pesquisa : D03.132.436.681.077.650 [Categoria DeCS]
Referências encontradas : 88 [refinar]
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[PMID]:15181735
[Au] Autor:Márk L; Erdej F; Dani G; Borbély M; Sziklai G; Nagy E; Hajdara I; Katona A
[Ad] Endereço:Békés Megyei Képviseló-testület Pándy Kálmán Kórháza, II. Belgyógyászat-Kardiológia, Gyula.
[Ti] Título:[Treatment of atrial fibrillation in a Hungarian hospital department of cardiologic internal medicine at the turn of the millennium].
[Ti] Título:Törekvés a pitvarfibrilláció ritmuskontroll-kezelésére kardiológiai profilú belgyógyászati osztályon az ezredfordulón..
[So] Source:Orv Hetil;145(19):1001-6, 2004 May 09.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION: The atrial fibrillation is a severe and frequent disease, which influences greatly the patients' quality of life. Only a few Hungarian studies exist which discuss the physicians' own experiences in its treatment. AIM: The description of the experiences acquired in an internal medicine department with cardiological profile during the treatment based on the actual guidelines and the review of the results of one year follow-up. METHOD: Retrospective analysis of the data of patients treated with atrial fibrillation between 1 january 1999 and 31 december 2001 and a one year follow-up was performed. The age, gender, success in cardioversion, the antiarrhythmic therapy at the discharge and the modification in it during the first year were evaluated. RESULTS: During the 3 years long period 1115 patients with atrial fibrillation were admitted (53.9% female, 46.1% male, the mean age was 72.0 +/- 10.4 years), 391 of whom were discharged with sinus rhythm. In 193 cases (49%) a spontaneous cardioversion was observed. 120 electrical (31%) and 78 pharmacological (20%) cardioversions were performed. The electrical form was carried out in 42 cases with acute atrial fibrillation (in 36 of them successfully) and in 100 cases as an elective procedure, in 84 successfully. Pharmacological cardioversion was made in 39 acute cases with the administration of propafenone (in 29 ones successfully) and in 57 elective cases with quinidine + beta-blocker + magnesium (in 49 ones successfully). For the maintenance of sinus rhythm in the 38.8% of cases amiodarone, 24.0% propafenone, 19.9% sotalol, 10.7% beta-blocker, 0.8% quinidine, 0.5% prajmaline was administered, and 5.1% of the patients didn't receive any special treatment. During the one year follow-up from the 391 patients 261 remained on sinus rhythm, in 81 cases (21%) the return of the atrial fibrillation was diagnosed (in 57 of them a successful cardioversion was performed again), 11 patients (3%) died and 38 (9%) were lost for observation. At the time of the one year control 57.8% of patients treated with amiodarone, 61.7% of those treated with propafenone, 67.9% with sotalol and 35.7% with beta-blocker remained on sinus rhythm. The amiodarone was omitted in 17 cases because of its side effects. CONCLUSIONS: The treatment of the atrial fibrillation has to be performed individually taking into account the guidelines, the comorbidity, the time of the beginning of rhythm disorder, the patients' present other drugs and the former antiarrhythmic therapy. A continuous and consistent follow-up of these patients is crucial.
[Mh] Termos MeSH primário: Antiarrítmicos/uso terapêutico
Fibrilação Atrial/terapia
Cardioversão Elétrica
[Mh] Termos MeSH secundário: Doença Aguda
Antagonistas Adrenérgicos beta/uso terapêutico
Idoso
Amiodarona/uso terapêutico
Fibrilação Atrial/tratamento farmacológico
Fibrilação Atrial/fisiopatologia
Serviço Hospitalar de Cardiologia
Feminino
Seguimentos
Departamentos Hospitalares
Seres Humanos
Hungria
Masculino
Meia-Idade
Prajmalina/uso terapêutico
Propafenona/uso terapêutico
Quinidina/uso terapêutico
Estudos Retrospectivos
Sotalol/uso terapêutico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic beta-Antagonists); 0 (Anti-Arrhythmia Agents); 68IQX3T69U (Propafenone); 75934UD4GJ (Prajmaline); A6D97U294I (Sotalol); ITX08688JL (Quinidine); N3RQ532IUT (Amiodarone)
[Em] Mês de entrada:0407
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040609
[St] Status:MEDLINE


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[PMID]:14567096
[Au] Autor:Piekarska A
[Ad] Endereço:Katedra i Klinika Chorób Zakaznych i Hepatologii Uniwersytetu Medycznego w Lodzi.
[Ti] Título:[Cholestatic hepatitis caused by prajmalium treatment: case report].
[Ti] Título:Cholestatyczne zapalenie watroby wywolane zastosowaniem prajmaliny--opis przypadku..
[So] Source:Pol Arch Med Wewn;109(6):629-32, 2003 Jun.
[Is] ISSN:1897-9483
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:Prajmalium rarely causes idiosyncratic liver injury. Author describes the case of cholestatic hepatitis occurring in three weeks after cessation of short-term treatment with prajmalium. Eighteen months later, despite of good general status, physical and biochemical features of cholestasis were present. Pathologic examination of liver biopsy specimen revealed the chronic intracellular cholestasis with lymphocytic infiltration. Presented case indicate that even short-term treatment with potentially weekly hepatotoxic drug may cause the long-term intrahepatic cholestasis.
[Mh] Termos MeSH primário: Antiarrítmicos/efeitos adversos
Doença Hepática Induzida por Substâncias e Drogas/complicações
Doença Hepática Induzida por Substâncias e Drogas/etiologia
Colestase Intra-Hepática/complicações
Prajmalina/efeitos adversos
[Mh] Termos MeSH secundário: Antiarrítmicos/administração & dosagem
Arritmias Cardíacas/tratamento farmacológico
Feminino
Seres Humanos
Meia-Idade
Prajmalina/administração & dosagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:0403
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031022
[St] Status:MEDLINE


  3 / 88 MEDLINE  
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Fotocópia
[PMID]:11560050
[Au] Autor:Fischer S; Reinhold S; Kettner W
[Ad] Endereço:Kardiologische Abteilung der Medizinischen Klinik, Städtisches Klinikum Magdeburg, Krankenhaus Altstadt. DrFischerS@web.de
[Ti] Título:[Brugada syndrome].
[Ti] Título:Das Brugada-Syndrom..
[So] Source:Med Klin (Munich);96(8):485-8, 2001 Aug 15.
[Is] ISSN:0723-5003
[Cp] País de publicação:Germany
[La] Idioma:ger
[Ab] Resumo:BACKGROUND: A high take-off descending ST segment associated with right bundle branch block is the typical ECG criterion of the Brugada-Brugada syndrome. It leads to ventricular fibrillation or syncopes in case of a familiar disposition. CASE REPORT: We describe a 56-year-old man in whom oral prajmalium bitartrate therapy previously prescribed for symptomatic ventricular extrasystoles unmasked an electrographic pattern characteristic of a Brugada syndrome. After the ongoing invasive diagnostic a right ventricular dysplasia in the same case is possible. The patient was treated with an ICD pacemaker.
[Mh] Termos MeSH primário: Antiarrítmicos/efeitos adversos
Displasia Arritmogênica Ventricular Direita/diagnóstico
Bloqueio de Ramo/complicações
Prajmalina/efeitos adversos
[Mh] Termos MeSH secundário: Displasia Arritmogênica Ventricular Direita/complicações
Bloqueio de Ramo/fisiopatologia
Angiografia Coronária
Diagnóstico Diferencial
Eletrocardiografia/efeitos dos fármacos
Seres Humanos
Masculino
Meia-Idade
Marca-Passo Artificial
Síndrome
Resultado do Tratamento
Fibrilação Ventricular/etiologia
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:0110
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:010919
[St] Status:MEDLINE


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Fotocópia
[PMID]:10944783
[Au] Autor:Hinse C; Stöckigt J
[Ad] Endereço:Institut für Pharmazie, Johannes Gutenberg-Universität, Mainz, Germany. stoeckig@mail.uni-mainz.de
[Ti] Título:The structure of the ring-opened N beta-propyl-ajmaline (Neo-Gilurytmal) at physiological pH is obviously responsible for its better absorption and bioavailability when compared with ajmaline (Gilurytmal).
[So] Source:Pharmazie;55(7):531-2, 2000 Jul.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Prajmaline, the semisynthetic propyl derivative of ajmaline, shows a much better bioavailability when compared with the Rauvolfia alkaloid ajmaline. Early NMR and IR-studies, fluorescence spectroscopic investigations and extraction experiments combined with ion-pair chromatography proved the thesis of a tautomeric equilibrium between an aldehyde-amine and a quaternary carbinol-ammonium component. The aim of this study was to confirm this thesis by HPLC-separation and by structure-determination of both tautomeric compounds.
[Mh] Termos MeSH primário: Ajmalina/química
Ajmalina/farmacocinética
Antiarrítmicos/química
Antiarrítmicos/farmacocinética
Prajmalina/química
Prajmalina/farmacocinética
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Concentração de Íons de Hidrogênio
Indicadores e Reagentes
Absorção Intestinal
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Relação Estrutura-Atividade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 0 (Indicators and Reagents); 1PON08459R (Ajmaline); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:0009
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:000817
[St] Status:MEDLINE


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[PMID]:10649215
[Au] Autor:Pasic M; Potapov E; Kuppe H; Hetzer R
[Ad] Endereço:Deutsches Herzzentrum, Berlin, Germany. pasic@dhzb.de
[Ti] Título:Prolonged cardiopulmonary bypass for severe drug intoxication.
[So] Source:J Thorac Cardiovasc Surg;119(2):379-80, 2000 Feb.
[Is] ISSN:0022-5223
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antiarrítmicos/envenenamento
Ponte Cardiopulmonar
Prajmalina/envenenamento
Fibrilação Ventricular/terapia
[Mh] Termos MeSH secundário: Adulto
Antiarrítmicos/sangue
Ponte Cardiopulmonar/métodos
Eletrocardiografia
Feminino
Meia-Vida
Frequência Cardíaca
Seres Humanos
Prajmalina/sangue
Tentativa de Suicídio
Fibrilação Ventricular/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:0003
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:000129
[St] Status:MEDLINE


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[PMID]:10389169
[Au] Autor:Revenko SV; Borovikova LV; Ermishkin VV
[Ad] Endereço:Cardiological Research Centre, Moscow, Russia.
[Ti] Título:[Stimulus-dependent effects of the sodium channel blockers in the C-fiber sensory units].
[Ti] Título:Stimulozavisimye éffekty pri deistvii blokatorov natrievykh kanalov na sensornye C-edinitsy..
[So] Source:Ross Fiziol Zh Im I M Sechenova;85(1):119-27, 1999 Jan.
[Is] ISSN:0869-8139
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The data obtained suggest a use-dependent inhibition in the skin terminals of the C-fibre sensory units. The terminals are discussed in respect to search of efficient local anaesthetising agents as well as cardiac anti-arrhythmic agents with obvious neurotropic effects.
[Mh] Termos MeSH primário: Fibras Nervosas/efeitos dos fármacos
Nociceptores/fisiologia
Pele/inervação
Canais de Sódio/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anestésicos Locais/farmacologia
Animais
Antiarrítmicos/farmacologia
Gatos
Estimulação Elétrica
Temperatura Alta
Lidocaína/farmacologia
Fibras Nervosas/fisiologia
Neurônios Aferentes/efeitos dos fármacos
Neurônios Aferentes/fisiologia
Estimulação Física
Prajmalina/farmacologia
Tato
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Anti-Arrhythmia Agents); 0 (Sodium Channels); 75934UD4GJ (Prajmaline); 98PI200987 (Lidocaine)
[Em] Mês de entrada:9907
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:990702
[St] Status:MEDLINE


  7 / 88 MEDLINE  
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Fotocópia
[PMID]:9340789
[Au] Autor:Petovský P; Malý J
[Ad] Endereço:Súdnolekárske oddelnie NsP, Nitra.
[Ti] Título:[A case of fatal poisoning with the anti-arrhythmia agents Katen and Neo-Gilurytmal].
[Ti] Título:Letálny prípad intoxikácie antiarytmikami Katen a Neo-Gilurytmal..
[So] Source:Soud Lek;42(2):18-20, 1997 May.
[Is] ISSN:0371-1854
[Cp] País de publicação:Czech Republic
[La] Idioma:slo
[Ab] Resumo:The case is presented on 17-year-old student who ingested larger doses of tablets and capsules in privacy. She ingested antiarrhythmics Katen and Neo-Gilurytmal without clinical therapy by these drugs and without history of suicidal attempt. The imminent case of death was asphyxiation by aspiration of vomits from gastric contents after ingestion of excessive doses of drugs. The secondary findings as brain edema, petechiae under the serous membranes and congestion of the abdominal cavity, were relieved at autopsy. Noxae was identified by the postmortem toxicological analysis of blood, liver, kidney, gastric contents and intestinal contents. Mexiletine and prajmaline were analysed by the capillary gas chromatography with FID detection. Retention time of mexiletine was 6.66 minutes, prajmaline 15.15 minutes, respectively. Blood alcohol concentration was 0.21 mg.g-1. Concentration of prajmaline in gastric contents was 3.03 mg.g-1, mexiletine 0.11 mg.g-1, respectively.
[Mh] Termos MeSH primário: Antiarrítmicos/envenenamento
Mexiletina/envenenamento
Prajmalina/envenenamento
[Mh] Termos MeSH secundário: Adolescente
Antiarrítmicos/farmacocinética
Evolução Fatal
Feminino
Medicina Legal
Seres Humanos
Mexiletina/farmacocinética
Prajmalina/farmacocinética
Distribuição Tecidual
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 1U511HHV4Z (Mexiletine); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:9710
[Cu] Atualização por classe:161021
[Lr] Data última revisão:
161021
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970501
[St] Status:MEDLINE


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Fotocópia
[PMID]:9182277
[Au] Autor:Berecz R; Llerena A; Benitez J
[Ti] Título:[Interaction between prajmaline and metoprotol: a possible pharmacogenetic explanation].
[Ti] Título:Interakció prajmalin és metoprolol között: egy lehetséges farmakogenetikai magyarázat..
[So] Source:Orv Hetil;138(17):1097-8, 1997 Apr 27.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Mh] Termos MeSH primário: Metoprolol
Prajmalina
[Mh] Termos MeSH secundário: Antiarrítmicos/efeitos adversos
Antiarrítmicos/metabolismo
Interações Medicamentosas
Metoprolol/efeitos adversos
Metoprolol/metabolismo
Farmacogenética
Prajmalina/efeitos adversos
Prajmalina/metabolismo
[Pt] Tipo de publicação:COMMENT; LETTER
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:9706
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970427
[St] Status:MEDLINE


  9 / 88 MEDLINE  
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Fotocópia
[PMID]:8649751
[Au] Autor:Almási R; Mágel F; Kósik G
[Ad] Endereço:Központi Aneszteziológia és Intenzív Betegellátó Osztály, Kaposi Mór Megyei Kórház, Kaposvár.
[Ti] Título:[Cardiogenic shock and ventricular fibrillation induced by prajmalium and metoprolol poisoning].
[Ti] Título:Kardiogén shock és kamrafibrilláció kialakulása prajmalin és metoprolol mérgezés következtében..
[So] Source:Orv Hetil;137(13):695-700, 1996 Mar 31.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:Prajmaline is not a relatively well known and frequently used antiarrhythmic belonging to Class IA group of antiarrhythmics, which was administered to a young male with metoprolol for the treatment of parasystole. The patient took in 120 mgs prajmaline and 600 mgs metoprolol during the day of the case, which leads to cardiogenic shock, ventricular tachycardia and ventricular fibrillation. The patient's parameters were normalized after successful resuscitation, temporary pacemaker and two days long Dopamin therapy. Therapy was not regarded to be necessary for a few ventricular premature beats detected during a week observation period. The patient is without complaints now, and significant ventricular arrhythmias, or malignant ventricular ectopy hasn't been proved with ECG tests and Holter monitoring for more than three months. Due to adverse effect profile of prajmaline, even at commonly used doses it should be administered carefully and other agents should probably be considered first before beginning long term treatment with prajmaline.
[Mh] Termos MeSH primário: Antiarrítmicos/envenenamento
Metoprolol/envenenamento
Prajmalina/envenenamento
Choque Cardiogênico/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Antiarrítmicos/administração & dosagem
Antiarrítmicos/farmacocinética
Relação Dose-Resposta a Droga
Overdose de Drogas
Sinergismo Farmacológico
Seres Humanos
Masculino
Metoprolol/administração & dosagem
Metoprolol/farmacocinética
Prajmalina/administração & dosagem
Prajmalina/farmacocinética
Fibrilação Ventricular/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline); GEB06NHM23 (Metoprolol)
[Em] Mês de entrada:9607
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:960331
[St] Status:MEDLINE


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Fotocópia
[PMID]:8834838
[Au] Autor:Janicki K; Orski J; Kakol J
[Ad] Endereço:Z I Katedry i Kliniki Chorób Wewnetrznych, Collegium Medicum, Uniwersytetu Jagiellonskiego w Krakowie.
[Ti] Título:[Antiarrhythmic effects of prajmaline (Neo-Gilurythmal) in stable angina pectoris in light of Holter electrocardiographic monitoring].
[Ti] Título:Przeciwarytmiczne efekty prajmaliny (Neo-Gilurytmal) w stabilnej dusznicy bolesnej w swietle holterowskich badan elektrokardiograficznych..
[So] Source:Przegl Lek;52(10):485-491, 1995.
[Is] ISSN:0033-2240
[Cp] País de publicação:Poland
[La] Idioma:pol
[Ab] Resumo:40 patients with various type of arrhytmia with stable angina were treated with 3 x 20mg Prajmalin (Neo-Gilurytmal) over 6-day period. A positive antyarhytmic response was observed in 30 patients (75%). In the remaining 10 patients considering the lack of adequate response after 6 days on 60 mg the trial was continued at a dose of 100 mg/day (5 x 20mg). With this dose bringing on the desired results. In 32 patients with VE'e and SVE's Neo-Gilurytmal was used in mono therapy. While in other types of arthymia it was used as previously as a first treatment and also in cases where other antiarhytmic drugs (e.g. Propahenone, Mexitil or Beta-blockers) were unsuccessful. Antiarhytmic effects were verified using 24-hour Holter monitoring before introduction of Neo-Gilurytmal, during the first fourth and seventh day of administration and also the eleventh day of observation (in 30 patients three days after cessation of treatment and in 10 cases three days after commencing on 100 mg daily). The results, as mean of the 24-hour observation was statistically analysed using the Wilcoxon test. We analysed the mean from the first day (H1), fourth day (H2), seventh day (H3) i.e. 6 days after administration and in 10 patients three day after increasing the dose to 100 mg/day (H4). We compared this to a base value (Ho) obtained before drug administration. The results obtained showed the Neo-Gilurythmal is an effective drug significantly reducing meanly VE's and SVE's and also gigemini, trigemini, coupled, runs. It was concluded that Neo-Gilurythmal did not significantly effect the heart rate and QT intervals and also QT adjusted to the heart rate. It was also noticed that these was a lack of therapeutic effect 3 days after cessation of treatment, which was suggested that constant therapy is required. Neo-Gilurythmal was find to be effective even in the case where other previously used antiarhymics were ineffective. We also observe a positive result in treatment of paroxismal tachycardia, in treatment of WPW Syndrome and also in prophylactic againts its recurrence. In our study no adverse effects (e.g. cardiac muscle depression, hypotensive episodes or noted in other studies gepatotoxicity or cholestatic episodes) were observed.
[Mh] Termos MeSH primário: Angina Pectoris/complicações
Antiarrítmicos/uso terapêutico
Arritmias Cardíacas/tratamento farmacológico
Prajmalina/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Arritmias Cardíacas/complicações
Arritmias Cardíacas/diagnóstico
Esquema de Medicação
Eletrocardiografia Ambulatorial
Feminino
Seres Humanos
Masculino
Meia-Idade
Taquicardia Paroxística/tratamento farmacológico
Resultado do Tratamento
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Arrhythmia Agents); 75934UD4GJ (Prajmaline)
[Em] Mês de entrada:9612
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:950101
[St] Status:MEDLINE



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