| [PMID]: | 28448905 |
| [Au] Autor: | Bluthenthal RN; Wenger L; Chu D; Bourgois P; Kral AH |
| [Ad] Endereço: | Department of Preventive Medicine, Institute for Prevention Research, Keck School of Medicine, University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90033, USA. Electronic address: rbluthen@usc.edu. |
| [Ti] Título: | Drug use generations and patterns of injection drug use: Birth cohort differences among people who inject drugs in Los Angeles and San Francisco, California. |
| [So] Source: | Drug Alcohol Depend;175:210-218, 2017 06 01. |
| [Is] ISSN: | 1879-0046 |
| [Cp] País de publicação: | Ireland |
| [La] Idioma: | eng |
| [Ab] Resumo: | OBJECTIVES: A robust literature documents generational trends in drug use. We examined the implications of changing national drug use patterns on drug injection histories of diverse people who inject drugs (PWID). METHODS: Drug use histories were collected from 776 active PWID in 2011-13. Using descriptive statistics, we examine drug use initiation by year and birth cohort (BC) differences in drug first injected. A multivariate linear regression model of time to injection initiation ([TTII] (year of first injection minus year of first illicit drug use) was developed to explore BC differences. RESULTS: The first drug injected by BC changed in tandem with national drug use trends with heroin declining from 77% for the pre-1960's BC to 58% for the 1960's BC before increasing to 71% for the 1990's BC. Multivariate linear regression modeling found that shorter TTII was associated with the 1980's/1990's BC (-3.50 years; 95% Confidence Interval [CI]=-0.79, -6.21) as compared to the 1970's BC. Longer TTII was associated with being female (1.65 years; 95% CI=0.40, 2.90), African American (1.69 years; 95% CI=0.43, 2.95), any substance use treatment prior to injection (4.22 years; 95% CI=2.65, 5.79), and prior non-injection use of drug that was first injected (3.29 years; 95% CI=2.19, 4.40). CONCLUSION: National drug trends appear to influence injection drug use patterns. The prescription opiate drug era is associated with shorter TTII. Culturally competent, demographically and generationally-targeted prevention strategies to combat transitions to drug injection are needed to prevent or shorten upstream increases in risky drug use practices on a national level. |
| [Mh] Termos MeSH primário: |
Fatores Etários
Abuso de Substâncias por Via Intravenosa/epidemiologia
Transtornos Relacionados ao Uso de Substâncias/epidemiologia
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| [Mh] Termos MeSH secundário: |
Adulto
Estudos de Coortes
Feminino
Heroína
Seres Humanos
Modelos Lineares
Los Angeles/epidemiologia
Masculino
Meia-Idade
Análise Multivariada
São Francisco/epidemiologia
Adulto Jovem
|
| [Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL |
[Nm] Nome de substância:
| 70D95007SX (Heroin) |
| [Em] Mês de entrada: | 1801 |
| [Cu] Atualização por classe: | 180123 |
[Lr] Data última revisão:
| 180123 |
| [Sb] Subgrupo de revista: | IM |
| [Da] Data de entrada para processamento: | 170428 |
| [St] Status: | MEDLINE |
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