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[PMID]:28383149
[Au] Autor:Kalalinia F; Karimi-Sani I
[Ad] Endereço:Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
[Ti] Título:Anticancer Properties of Solamargine: A Systematic Review.
[So] Source:Phytother Res;31(6):858-870, 2017 Jun.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cancers are usually treated by anticancer agents that are toxic for both normal and cancer cells, so these drugs have major side effects and they are not suitable and enough effective for cancer prevention. Solamargine, a steroidal alkaloid glycoside found in Solanum species such as Solanum nigrum, displayed several therapeutic activities. We aim to review the use of solamargine in experimental cancer studies. Articles published in biology journals between 1975 and 2017 were retrieved from PubMed, Scopus, and Web of Science using relevant keywords. The scientific papers mainly focusing on solamargine with therapeutic efficacies against cancers were identified and tabulated. In addition, the reliability of experimental findings was determined under "Risk of Bias" criteria. The author manually reviewed 33 articles; 27 articles were found concerning the anti-cancer potential in cancer cells. Solamargine has been found to possess anticancer activities via its effect on a variety of biological pathways including cell survival pathways, tumor suppressor pathways, caspase activation pathway, mitochondrial pathways, death receptor pathways, protein kinase pathways, and signal pathways, which promote invasion/migration and multi drug resistance. Solamargine can be an anticancer agent candidate when complementary scientific evidences become available. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Neoplasias/tratamento farmacológico
Alcaloides de Solanáceas/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Mitocôndrias/efeitos dos fármacos
Reprodutibilidade dos Testes
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Solanaceous Alkaloids); 3671-38-3 (beta-solamarine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170407
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5809


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[PMID]:28283413
[Au] Autor:Shen KH; Hung JH; Chang CW; Weng YT; Wu MJ; Chen PS
[Ad] Endereço:Division of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan; Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan; Department of Urology, Taipei Medical University, Taipei, Taiwan.
[Ti] Título:Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression.
[So] Source:Chem Biol Interact;268:129-135, 2017 Apr 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Solasodine, a naturally occurring aglycone of glycoalkaloid in eggplant (Solanum melongena), was found to inhibit proliferation in various tumor cells. However, the effect of solasodine on cancer cell metastasis remains unclear. This study investigates the suppression mechanism of solasodine on motility of human lung cancer cell A549 in vitro. Results show that solasodine reduces viability of A549 cells. Treatment with non-toxic doses of solasodine suppresses markedly cell invasion. Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2. Immunoblotting assays indicate that solasodine is effective in suppressing PI3K and Akt phosphorylation. Moreover, solasodine downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. Downregulation of miR-21 by miR-21 inhibitor increases RECK expression and decreases cell invasion, suggesting that downregulation of miR-21 by solasodine may contribute to elevate RECK expression and subsequently inhibiting cell invasion. Taken together, the results reveal that inhibition of A549 cell invasion by solasodine may be, at least in part, through blocking MMP expression. Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21. These findings demonstrate an attractive therapeutic potential for solasodine in lung cancer anti-metastatic therapy.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Neoplasias Pulmonares/tratamento farmacológico
Metaloproteinases da Matriz/metabolismo
MicroRNAs/metabolismo
Alcaloides de Solanáceas/farmacologia
[Mh] Termos MeSH secundário: Células A549
Basigina/genética
Basigina/metabolismo
Regulação para Baixo
Proteínas Ligadas por GPI/genética
Proteínas Ligadas por GPI/metabolismo
Seres Humanos
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/metabolismo
Metaloproteinase 9 da Matriz/genética
Metaloproteinase 9 da Matriz/metabolismo
Metaloproteinases da Matriz/genética
MicroRNAs/genética
Invasividade Neoplásica
Metástase Neoplásica
Fosfatidilinositol 3-Quinases/genética
Fosfatidilinositol 3-Quinases/metabolismo
Fosforilação
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Inibidor Tecidual de Metaloproteinase-1/genética
Inibidor Tecidual de Metaloproteinase-1/metabolismo
Inibidor Tecidual de Metaloproteinase-2/genética
Inibidor Tecidual de Metaloproteinase-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (BSG protein, human); 0 (GPI-Linked Proteins); 0 (MIRN21 microRNA, human); 0 (MicroRNAs); 0 (RECK protein, human); 0 (Solanaceous Alkaloids); 0 (TIMP1 protein, human); 0 (TIMP2 protein, human); 0 (Tissue Inhibitor of Metalloproteinase-1); 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2); 136894-56-9 (Basigin); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.24.- (Matrix Metalloproteinases); EC 3.4.24.24 (MMP2 protein, human); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (MMP9 protein, human); EC 3.4.24.35 (Matrix Metalloproteinase 9); L40Y453Y96 (solasodine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE


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[PMID]:27620163
[Au] Autor:Chen Y; Tang Q; Xiao Q; Yang L; Hann SS
[Ad] Endereço:Laboratory of Tumor Biology, Department of Medical Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical Collage, University of Guangzhou Traditional Chinese Medicine, Guangzhou, China.
[Ti] Título:Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
[So] Source:J Cell Mol Med;21(2):222-233, 2017 Feb.
[Is] ISSN:1582-4934
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lung cancer is the most common cancer and the leading cause of cancer deaths worldwide. We previously showed that solamargine, one natural phytochemicals from traditional plants, inhibited the growth of lung cancer cells through inhibition of prostaglandin E2 (PGE ) receptor EP4. However, the potential downstream effectors of EP4 involving in the anti-lung cancer effects of solamargine still remained to be determined. In this study, we further verified that solamargine inhibited growth of non-small-cell lung cancer (NSCLC) cells in multiple cell lines. Mechanistically, solamargine increased phosphorylation of ERK1/2. Moreover, solamargine inhibited the protein expression of DNA methyltransferase 1 (DNMT1) and c-Jun, which were abrogated in cells treated with MEK/ERK1/2 inhibitor (PD98059) and transfected with exogenously expressed DNMT1 gene, respectively. Interestingly, overexpressed DNMT1 gene antagonized the effect of solamargine on c-Jun protein expression. Intriguingly, overexpressed c-Jun blocked solamargine-inhibited lung cancer cell growth, and feedback resisted the solamargine-induced phosphorylation of ERK1/2. A nude mouse xenograft model implanted with lung cancer cells in vivo confirmed the results in vitro. Collectively, our results show that solamargine inhibits the growth of human lung cancer cells through reduction of EP4 protein expression, followed by increasing ERK1/2 phosphorylation. This results in decrease in DNMT1 and c-Jun protein expressions. The inter-correlations between EP4, DNMT1 and c-Jun and feedback regulation of ERK1/2 by c-Jun contribute to the overall responses of solamargine in this process. This study uncovers an additional novel mechanism by which solamargine inhibits growth of human lung cancer cells.
[Mh] Termos MeSH primário: DNA (Citosina-5-)-Metiltransferases/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Neoplasias Pulmonares/enzimologia
Neoplasias Pulmonares/patologia
Terapia de Alvo Molecular
Proteínas Proto-Oncogênicas c-jun/metabolismo
Receptores de Prostaglandina E Subtipo EP4/metabolismo
Alcaloides de Solanáceas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Carcinoma Pulmonar de Células não Pequenas/enzimologia
Carcinoma Pulmonar de Células não Pequenas/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
DNA (Citosina-5-)-Metiltransferase 1
Ativação Enzimática/efeitos dos fármacos
Retroalimentação Fisiológica/efeitos dos fármacos
Feminino
Seres Humanos
Neoplasias Pulmonares/tratamento farmacológico
Camundongos Nus
Fosforilação/efeitos dos fármacos
Alcaloides de Solanáceas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Proto-Oncogene Proteins c-jun); 0 (Receptors, Prostaglandin E, EP4 Subtype); 0 (Solanaceous Alkaloids); 3671-38-3 (beta-solamarine); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases); EC 2.1.1.37 (DNMT1 protein, human); EC 2.1.1.37 (Dnmt1 protein, mouse); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE
[do] DOI:10.1111/jcmm.12958


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[PMID]:27462871
[Au] Autor:Xu XH; Zhang LL; Wu GS; Chen X; Li T; Chen X; Wang YT; Lu JJ
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
[Ti] Título:Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells.
[So] Source:Planta Med;83(3-04):254-260, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Solasodine, a steroidal alkaloid isolated from solanaceous species, exhibits anticancer activities on several cell lines. This study aimed to explore the antitumor potential of solasodine on ovarian cancer cells. The MTT assay, lactate dehydrogenase release assay, Hoechst 33342 staining, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-imidacarbocyanine staining assay, and Annexin V/PI assay were conducted to investigate the antiproliferation and apoptosis-inducing effects of solasodine. Monodansylcadaverine staining was performed to label the acidic puncta on ovarian cancer HEY cells. A wound healing assay and Transwell assay were carried out to determine whether solasodine elicits an antimetastatic effect on HEY cells. A gelatin zymography assay was applied to detect the enzymatic activities of matrix metalloproteinases. Western blot was employed to examine relevant protein expression. Results revealed that solasodine inhibited cell viabilities in a time- and dose-dependent manner, triggered apoptotic body formation, reduced cell mitochondrial membrane potential, and interfered with autolysosome degradation in ovarian cancer cells. Solasodine also suppressed the migration and invasion of HEY cells by downregulating matrix metalloproteinase expression and activities. This study could be used as a basis for further studies on the molecular mechanisms of the antiproliferation, apoptosis-inducing, autophagy-modifying, and antimetastatic activities of solasodine.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Neoplasias Ovarianas/tratamento farmacológico
Alcaloides de Solanáceas/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Regulação para Baixo/efeitos dos fármacos
Feminino
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Invasividade Neoplásica/prevenção & controle
Metástase Neoplásica
Neoplasias Ovarianas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Solanaceous Alkaloids); L40Y453Y96 (solasodine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-113000


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[PMID]:27754442
[Au] Autor:Yang J; Huang W; Tan W
[Ad] Endereço:Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. 14211030042@fudan.edu.cn.
[Ti] Título:Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity.
[So] Source:Molecules;21(10), 2016 Oct 14.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The major obstacle limiting the efficacy of current Smoothened (Smo) inhibitors is the primary and acquired resistance mainly caused by Smo mutations and Gli amplification. In this context, developing Hh inhibitors targeting Gli, the final effector of this signaling pathway, may combat the resistance. In this study we found that solasonine, a natural glycoalkaloid compound, significantly inhibited the hedgehog (Hh) pathway activity. Meanwhile, solasonine may obviously inhibit the alkaline phosphatase (ALP) activity in C3H10T1/2 cells, concomitantly with reductions of the mRNA expression of and . However, we found that solasonine exhibited no effect on the transcriptional factors activities provoked by TNF-α and PGE2, thus suggesting its selectivity against Hh pathway activity. Furthermore, we identified that solasonine inhibited the Hh pathway activity by acting on its transcriptional factor Gli using a series of complementary data. We also observed that solasonine obviously inhibited the Gli-luciferase activity provoked by ectopic expression of Smo mutants which may cause the resistance to the current Smo inhibitors. Our study suggests that solasonine may significantly inhibit the Hh pathway activity by acting on Gli, therefore indicating the possibility to use solasonine as a lead compound to develop anticancer drugs for combating the resistance of current Smo inhibitors.
[Mh] Termos MeSH primário: Alcaloides de Solanáceas/farmacologia
Transcrição Genética/efeitos dos fármacos
Proteína GLI1 em Dedos de Zinco/genética
[Mh] Termos MeSH secundário: Fosfatase Alcalina/metabolismo
Animais
Linhagem Celular
Regulação da Expressão Gênica/efeitos dos fármacos
Células HEK293
Proteínas Hedgehog/genética
Proteínas Hedgehog/metabolismo
Seres Humanos
Camundongos
Células NIH 3T3
Receptor Patched-1/genética
Transdução de Sinais/efeitos dos fármacos
Proteína GLI1 em Dedos de Zinco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hedgehog Proteins); 0 (Patched-1 Receptor); 0 (Solanaceous Alkaloids); 0 (Zinc Finger Protein GLI1); 5YG8GM566A (alpha-solamargine); EC 3.1.3.1 (Alkaline Phosphatase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161019
[St] Status:MEDLINE


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[PMID]:27470478
[Au] Autor:Li N; Liu X; Sun X
[Ti] Título:[A case of neonatal anisodamine poisoning].
[So] Source:Zhonghua Er Ke Za Zhi;54(1):68, 2016 Jan.
[Is] ISSN:0578-1310
[Cp] País de publicação:China
[La] Idioma:chi
[Mh] Termos MeSH primário: Alcaloides de Solanáceas/envenenamento
[Mh] Termos MeSH secundário: Seres Humanos
Recém-Nascido
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solanaceous Alkaloids); 01343Q8EL8 (anisodamine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160729
[Lr] Data última revisão:
160729
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0578-1310.2016.01.017


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[PMID]:27309358
[Au] Autor:Lenzi EK; Novatski A; Farago PV; Almeida MA; Zawadzki SF; Menechini Neto R
[Ad] Endereço:Departamento de Física, Universidade Estadual de Ponta Grossa, Ponta Grossa, 84030-900, Brazil.
[Ti] Título:Diffusion Processes and Drug Release: Capsaicinoids - Loaded Poly (ε-caprolactone) Microparticles.
[So] Source:PLoS One;11(6):e0157662, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present a generalmodel based on fractional diffusion equation coupled with a kinetic equation through the boundary condition. It covers several scenarios that may be characterized by usual or anomalous diffusion or present relaxation processes on the surface with non-Debye characteristics. A particular case of this model is used to investigate the experimental data obtained from the drug release of the capsaicinoids-loaded Poly (ε-caprolactone) microparticles. These considerations lead us to a good agreement with experimental data and to the conjecture that the burst effect, i.e., an initial large bolus of drug is released before the release rate reaches a stable profile, may be related to an anomalous diffusion manifested by the system.
[Mh] Termos MeSH primário: Catecóis/química
Portadores de Fármacos/química
Liberação Controlada de Fármacos
Poliésteres/química
Alcaloides de Solanáceas/química
[Mh] Termos MeSH secundário: Difusão
Composição de Medicamentos
Cinética
Tamanho da Partícula
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Drug Carriers); 0 (Polyesters); 0 (Solanaceous Alkaloids); 24980-41-4 (polycaprolactone)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0157662


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[PMID]:27211688
[Au] Autor:Sweat KG; Broatch J; Borror C; Hagan K; Cahill TM
[Ad] Endereço:School of Mathematical and Natural Sciences, Arizona State University, West Campus, 4701 W Thunderbird Rd, Glendale, AZ 85306, United States.
[Ti] Título:Variability in capsaicinoid content and Scoville heat ratings of commercially grown Jalapeño, Habanero and Bhut Jolokia peppers.
[So] Source:Food Chem;210:606-12, 2016 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The variability of capsaicinoid content of three common, commercially-available hot pepper varieties, namely Jalapeño, Habanero and Bhut Jolokia, was investigated. For each variety tested, ten peppers were acquired from each of ten different suppliers resulting in 100 peppers per variety that were individually analyzed. The results showed that different pepper varieties had different distribution types. The Habanero peppers showed a normal distribution; the Bhut Jolokia showed a skewed distribution and the Jalapeño peppers showed a very skewed distribution. The source of variability was also different; the Habaneros were very consistent within a given pepper supplier so most of the overall variation resulted from differences between suppliers. The Jalapeño peppers were the exact opposite with a very high degree of variability within a given supplier and relatively low variation between suppliers. A bootstrap statistical simulation was conducted on the data to suggest a minimum number of peppers to analyze to characterize the variation in a population. The simulations indicated that small sample sizes are effective at estimating the mean concentrations, but a sample size of ten or more is necessary to describe the population and capture the high-end tail of the distributions, which are the very hottest peppers.
[Mh] Termos MeSH primário: Capsaicina/análise
Capsicum/química
Capsicum/classificação
Frutas/química
Paladar
[Mh] Termos MeSH secundário: Catecóis
Ácidos Graxos Monoinsaturados
Alcamidas Poli-Insaturadas
Alcaloides de Solanáceas
Verduras
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Catechols); 0 (Fatty Acids, Monounsaturated); 0 (Polyunsaturated Alkamides); 0 (Solanaceous Alkaloids); S07O44R1ZM (Capsaicin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


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[PMID]:27075374
[Au] Autor:Chen W; Wu L; Jian XL; Zhang B; Li JY; Qin XL; Yu B
[Ad] Endereço:Dr Chen is Associate Chief Physician, Department of Ophthalmology, Peking University Shenzhen Guangdong, China. Drs Wu and Jian are Residents, Dr Qin is an Attending Physician, and Dr Yu is Chief Physician, Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China, a
[Ti] Título:Retinal Branch Artery Embolization Following Hyaluronic Acid Injection: A Case Report.
[So] Source:Aesthet Surg J;36(7):NP219-24, 2016 Jul.
[Is] ISSN:1527-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Injection of hyaluronic acid (HA) filler is a common aesthetic procedure. Impairment of vision, although rare, is a devastating complication of this procedure, which may not be reversible. We report on a patient who experienced visual acuity impairment and ischemic oculomotor nerve palsy after injection of HA into the nasal dorsum. In this case, clinical signs improved within 14 days of treatment. We also provide a review of the mechanism, clinical features, risk factors, and prevention and treatment strategies relating to embolization of ocular circulation after injection of HA. Vision loss is a rare but devastating complication of injection of hyaluronic acid (HA) in the face. Visual acuity seldom recovers completely. We report on a 22-year-old Asian woman who experienced obstruction of a branch of the retinal artery after injection of HA to augment her nose. The patient's visual acuity declined shortly after the procedure, and ophthalmoplegia occurred. Combination treatment was administered to restore the perfusion and oxygen supply to the retina and optic nerve. Within 14 days of rigorous treatment, the patient experienced improvement in visual acuity, extraocular movement, and visual field defects. LEVEL OF EVIDENCE 5: Risk.
[Mh] Termos MeSH primário: Arteriopatias Oclusivas/induzido quimicamente
Arteriopatias Oclusivas/tratamento farmacológico
Técnicas Cosméticas/efeitos adversos
Ácido Hialurônico/efeitos adversos
Transtornos da Visão/induzido quimicamente
Transtornos da Visão/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Alprostadil/uso terapêutico
Dexametasona/uso terapêutico
Dextranos/uso terapêutico
Feminino
Seres Humanos
Metacrilatos/uso terapêutico
Cavidade Nasal
Oftalmoplegia/induzido quimicamente
Oftalmoplegia/tratamento farmacológico
Oxigênio/uso terapêutico
Artéria Retiniana/fisiopatologia
Alcaloides de Solanáceas/uso terapêutico
Timolol/uso terapêutico
Tobramicina/uso terapêutico
Vitamina B 12/análogos & derivados
Vitamina B 12/uso terapêutico
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dextrans); 0 (Methacrylates); 0 (Solanaceous Alkaloids); 01343Q8EL8 (anisodamine); 7S5I7G3JQL (Dexamethasone); 817W3C6175 (Timolol); 9004-61-9 (Hyaluronic Acid); BR1SN1JS2W (mecobalamin); F5TD010360 (Alprostadil); L256JB984D (ozagrel); P6YC3EG204 (Vitamin B 12); S88TT14065 (Oxygen); VZ8RRZ51VK (Tobramycin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160415
[St] Status:MEDLINE
[do] DOI:10.1093/asj/sjw054


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[PMID]:27010563
[Au] Autor:Eisenkraft A; Falk A
[Ad] Endereço:Israel Ministry of Defense, HaKirya, Tel Aviv, Israel.
[Ti] Título:Possible role for anisodamine in organophosphate poisoning.
[So] Source:Br J Pharmacol;173(11):1719-27, 2016 Jun.
[Is] ISSN:1476-5381
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In cases of organophosphate poisoning, patients are treated with a combination of antidotes. In addition to these poison-directed antidotes, patients may require extra oxygen and artificial ventilation; other modalities may also be needed due to the wide range of toxic effects. Anisodamine is a belladonna alkaloid, and like other drugs from this family is non subtype-selective muscarinic, and a nicotinic cholinoceptor antagonist, which has been employed in traditional Chinese medicine. As a muscarinic antagonist, it displays similar pharmacological effects to atropine and scopolamine. However, anisodamine is not only less potent than atropine and scopolamine but also less toxic. Current in vitro and animal model studies have demonstrated that anisodamine has protective effects in a variety of diseases. Organophosphate poisoning involves not only the central and peripheral nervous systems, but also the cardiac and respiratory systems, as well as activation of inflammatory processes and oxidative stress. Therefore, the anticholinergic and additional activities of anisodamine appear to be relevant and justify its consideration as an addition to the existing remedies. However, more research is needed, as at present data on the role of anisodamine in the management of organophosphate poisoning are limited. Here, we review the beneficial effects of anisodamine on processes relevant to organophosphate poisoning.
[Mh] Termos MeSH primário: Antídotos/uso terapêutico
Intoxicação por Organofosfatos/tratamento farmacológico
Alcaloides de Solanáceas/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidotes); 0 (Solanaceous Alkaloids); 01343Q8EL8 (anisodamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160325
[St] Status:MEDLINE
[do] DOI:10.1111/bph.13486



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