[PMID]: | 25820039 |
[Au] Autor: | Jiang QW; Chen MW; Cheng KJ; Yu PZ; Wei X; Shi Z |
[Ad] Endereço: | Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, 510632, Guangdong, China. |
[Ti] Título: | Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases. |
[So] Source: | Med Res Rev;36(1):119-43, 2016 Jan. |
[Is] ISSN: | 1098-1128 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Steroidal alkaloids are a class of secondary metabolites isolated from plants, amphibians, and marine invertebrates. Evidence accumulated in the recent two decades demonstrates that steroidal alkaloids have a wide range of bioactivities including anticancer, antimicrobial, anti-inflammatory, antinociceptive, etc., suggesting their great potential for application. It is therefore necessary to comprehensively summarize the bioactivities, especially anticancer activities and mechanisms of steroidal alkaloids. Here we systematically highlight the anticancer profiles both in vitro and in vivo of steroidal alkaloids such as dendrogenin, solanidine, solasodine, tomatidine, cyclopamine, and their derivatives. Furthermore, other bioactivities of steroidal alkaloids are also discussed. The integrated molecular mechanisms in this review can increase our understanding on the utilization of steroidal alkaloids and contribute to the development of new drug candidates. Although the therapeutic potentials of steroidal alkaloids look promising in the preclinical and clinical studies, further pharmacokinetic and clinical studies are mandated to define their efficacy and safety in cancer and other diseases. |
[Mh] Termos MeSH primário: |
Alcaloides/uso terapêutico Neoplasias/tratamento farmacológico Esteroides/uso terapêutico
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[Mh] Termos MeSH secundário: |
Alcaloides/química Androgênios/química Animais Anti-Inflamatórios/química Antineoplásicos/química Linhagem Celular Tumoral Diosgenina/química Estrogênios/química Seres Humanos Camundongos Alcaloides de Solanáceas/química Tomatina/análogos & derivados Tomatina/química Alcaloides de Veratrum/química
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW |
[Nm] Nome de substância:
| 0 (Alkaloids); 0 (Androgens); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents); 0 (Estrogens); 0 (Solanaceous Alkaloids); 0 (Steroids); 0 (Veratrum Alkaloids); 2B73S48786 (tomatidine); 31U6547O08 (Tomatine); K49P2K8WLX (Diosgenin); L40Y453Y96 (solasodine); W7801OHM8B (solanidine); ZH658AJ192 (cyclopamine) |
[Em] Mês de entrada: | 1609 |
[Cu] Atualização por classe: | 151215 |
[Lr] Data última revisão:
| 151215 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 150331 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1002/med.21346 |
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