Base de dados : MEDLINE
Pesquisa : D03.132.920.256.543 [Categoria DeCS]
Referências encontradas : 83 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 9 ir para página                      

  1 / 83 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
[PMID]:18604017
[Au] Autor:Rauniar GP; Deo S; Bhattacharya SK
[Ad] Endereço:Department of Pharmacology, BP Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal. gprauniar@hotmail.com
[Ti] Título:Evaluation of anxiolytic activity of tensarin in mice.
[So] Source:Kathmandu Univ Med J (KUMJ);5(2):188-94, 2007 Apr-Jun.
[Is] ISSN:1812-2078
[Cp] País de publicação:Nepal
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Anxiolytic drugs are amongst the most frequently prescribed drugs. Available anxiolytic agents are associated with several limitations. Several indigenous drugs are being evaluated but none has been proved to be effective. OBJECTIVES: Aim of the present study is to evaluate the anxiolytic effect of Tensarin. MATERIAL AND METHOD: The behavioural tests were conducted with single dose schedule and multiple seven-dose schedules of Tensarin 50mg/kg, 100mg/kg and 200mg/kg in comparison with Diazepam 1mg/kg in mice using open field test, activity-monitoring and passive avoidance test. There were eight treatment groups in each treatment schedule. Each group consisted of ten animals of either sex. The data obtained were analyzed using non- parametric test and P-value of less than 0.05 was considered to be statistically significant. RESULTS: Multiple doses produced anxiolytic effect as indicated by an increase in rearing, number of crossing and the time spent by the animals in Central Square. It was also seen that there was significant decrease in step down latency, increase in step down error and time spent by animal in shock zone, these effects were not observed in single dose study. CONCLUSION: Tensarin shows a dose dependent anxiolytic effect but further studies are needed to find out the exact mechanism of action of the formulation.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Protoveratrinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/administração & dosagem
Comportamento Animal/efeitos dos fármacos
Diazepam/farmacologia
Feminino
Masculino
Camundongos
Protoveratrinas/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Protoveratrines); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1012
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080708
[St] Status:MEDLINE


  2 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:12817935
[Au] Autor:Tai YC; Chatziioannou AF; Yang Y; Silverman RW; Meadors K; Siegel S; Newport DF; Stickel JR; Cherry SR
[Ad] Endereço:UCLA, Crump Institute for Molecular Imaging, Los Angeles, CA 90095-1770, USA.
[Ti] Título:MicroPET II: design, development and initial performance of an improved microPET scanner for small-animal imaging.
[So] Source:Phys Med Biol;48(11):1519-37, 2003 Jun 07.
[Is] ISSN:0031-9155
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:MicroPET II is a second-generation animal PET scanner designed for high-resolution imaging of small laboratory rodents. The system consists of 90 scintillation detector modules arranged in three contiguous axial rings with a ring diameter of 16.0 cm and an axial length of 4.9 cm. Each detector module consists of a 14 x 14 array of lutetium oxyorthosilicate (LSO) crystals coupled to a multi-channel photomultiplier tube (MC-PMT) through a coherent optical fibre bundle. Each LSO crystal element measures 0.975 mm x 0.975 mm in cross section by 12.5 mm in length. A barium sulphate reflector material was used between LSO elements leading to a detector pitch of 1.15 mm in both axial and transverse directions. Fused optical fibre bundles were made from 90 microm diameter glass fibres with a numerical aperture of 0.56. Interstitial extramural absorber was added between the fibres to reduce optical cross talk. A charge-division readout circuit was implemented on printed circuit boards to decode the 196 crystals in each array from the outputs of the 64 anode signals of the MC-PMT. Electronics from Concorde Microsystems Inc. (Knoxville, TN) were used for signal amplification, digitization, event qualification, coincidence processing and data capture. Coincidence data were passed to a host PC that recorded events in list mode. Following acquisition, data were sorted into sinograms and reconstructed using Fourier rebinning and filtered hackprojection algorithms. Basic evaluation of the system has been completed. The absolute sensitivity of the microPET II scanner was 2.26% at the centre of the field of view (CFOV) for an energy window of 250-750 keV and a timing window of 10 ns. The intrinsic spatial resolution of the detectors in the system averaged 1.21 mm full width at half maximum (FWHM) when measured with a 22Na point source 0.5 mm in diameter. Reconstructed image resolution ranged from 0.83 mm FWHM at the CFOV to 1.47 mm FWHM in the radial direction, 1.17 mm FWHM in the tangential direction and 1.42 mm FWHM in the axial direction at 1 cm offset from the CFOV. These values represent highly significant improvements over our earlier microPET scanner (approximately fourfold sensitivity increase and 25-35% improvement in linear spatial resolution under equivalent operating conditions) and are expected to be further improved when the system is fully optimized.
[Mh] Termos MeSH primário: Osso e Ossos/diagnóstico por imagem
Análise de Falha de Equipamento
Coração/diagnóstico por imagem
Tomografia Computadorizada de Emissão/instrumentação
Transdutores
[Mh] Termos MeSH secundário: Animais
Estudos de Viabilidade
Camundongos
Miniaturização
Imagens de Fantasmas
Protoveratrinas
Controle de Qualidade
Ratos
Reprodutibilidade dos Testes
Contagem de Cintilação
Sensibilidade e Especificidade
Tomografia Computadorizada de Emissão/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Protoveratrines)
[Em] Mês de entrada:0402
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030624
[St] Status:MEDLINE


  3 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:9375326
[Au] Autor:Trbovic SM; Radulovacki M; Carley DW
[Ad] Endereço:Department of Pharmacology, University of Illinois College of Medicine at Chicago 60612, USA.
[Ti] Título:Protoveratrines A and B increase sleep apnea index in Sprague-Dawley rats.
[So] Source:J Appl Physiol (1985);83(5):1602-6, 1997 Nov.
[Is] ISSN:8750-7587
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The action of protovertarines A and B, which stimulate carotid sinus baroreceptors and vagal sensory endings in the heart as well as pulmonary bed, were assessed on spontaneous and postsigh central sleep apneas in freely moving Sprague-Dawley rats. During the 6-h recording period, animals were simultaneously monitored for sleep by using electroencephalogram and electromyogram recordings, for respiration by single-chamber plethysmography, and for blood pressure and heart period by using radiotelemetry. After administration of 0.2, 0.5, or 1 mg/kg sc of protoveratrines, cardiopulmonary changes lasting at least 6 h were observed in all three behavioral states [heart period increased up to 23% in wakefulness, 21% in non-rapid-eye-movement (non-REM) sleep, and 20% in REM sleep; P < 0.005 for each]. At the same time, there was a substantial increase in the number of spontaneous (375% increase; P = 0.04) and postsigh (268% increase, P = 0.0002) apneas. Minute ventilation decreased by up to 24% in wakefulness, 25% in non-REM, and 35% in REM sleep (P < 0.05 for each). We conclude that pharmacological stimulation of baroreflexes promotes apnea expression in the sleeping rat.
[Mh] Termos MeSH primário: Anti-Hipertensivos/farmacologia
Protoveratrinas/farmacologia
Síndromes da Apneia do Sono/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Barorreflexo/efeitos dos fármacos
Relação Dose-Resposta a Droga
Eletroencefalografia/efeitos dos fármacos
Eletromiografia/efeitos dos fármacos
Frequência Cardíaca/efeitos dos fármacos
Masculino
Circulação Pulmonar/efeitos dos fármacos
Receptores Pulmonares de Alongamento/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Mecânica Respiratória/efeitos dos fármacos
Síndromes da Apneia do Sono/fisiopatologia
Sono REM/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antihypertensive Agents); 0 (Protoveratrines)
[Em] Mês de entrada:9712
[Cu] Atualização por classe:130926
[Lr] Data última revisão:
130926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:980107
[St] Status:MEDLINE


  4 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:8301366
[Au] Autor:Miller AD; Ruggiero DA
[Ad] Endereço:Rockefeller University, New York, New York 10021.
[Ti] Título:Emetic reflex arc revealed by expression of the immediate-early gene c-fos in the cat.
[So] Source:J Neurosci;14(2):871-88, 1994 Feb.
[Is] ISSN:0270-6474
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The organization of the central neuronal circuitry that produces vomiting was explored by mapping the distribution of c-fos protein (Fos)-like immunoreactivity (FLI) as a monitor of functional activity. The brainstem and spinal cord were examined in cats administered multiple emetic drugs (cisplatin, lobeline, protoveratrine, naloxone, apomorphine) or control saline injections. Some animals were decerebrated, paralyzed, and artificially ventilated to avoid possible Fos expression induced by sensory feedback or fluid depletion during vomiting. Fictive vomiting was identified in these animals by a characteristic pattern of respiratory muscle nerve (phrenic and abdominal) coactivation. Tissues were immunoprocessed using an antibody raised against amino acids 1-131 of Fos and the avidin-biotin peroxidase complex method. Enhanced nuclear FLI was observed in experimental animals along portions of the sensorimotor emetic reflex arc, including the nodose ganglia, area postrema, nuclei of the solitary tract (especially medial and subpostrema subnuclei), intermediate reticular zone of the lateral tegmental field, nucleus retroambiguus, C2 inspiratory propriospinal cell region, and dorsal vagal and phrenic motor nuclei. Enhanced FLI was also detected in the raphe magnus, subretrofacial nucleus, and spinal dorsal horn. Regions showing no recognizable differences in FLI between experimental and control animals included the vestibular, cochlear, spinal trigeminal, subtrigeminal, and lateral reticular nuclei. Only minor differences were observed in the distributions of FLI between intact and decerebrate animals. No unique, well-defined group of labeled neurons that might function as a "vomiting center" could be identified. Instead, the pattern of c-fos expression suggests that neurons involved in coordinating the emetic response may radiate from the area postrema and nucleus of the solitary tract to an arc in the lateral tegmental field implicated in somato-autonomic integration.
[Mh] Termos MeSH primário: Tronco Encefálico/metabolismo
Plexo Cervical/fisiologia
Eméticos/farmacologia
Expressão Gênica/efeitos dos fármacos
Genes Precoces
Genes fos
Neurônios/metabolismo
Nervo Frênico/fisiologia
Medula Espinal/metabolismo
[Mh] Termos MeSH secundário: Animais
Apomorfina/farmacologia
Tronco Encefálico/efeitos dos fármacos
Gatos
Plexo Cervical/efeitos dos fármacos
Cisplatino/farmacologia
Estado de Descerebração
Lobelina/farmacologia
Bulbo/efeitos dos fármacos
Bulbo/metabolismo
Naloxona/farmacologia
Neurônios/efeitos dos fármacos
Especificidade de Órgãos
Nervo Frênico/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-fos/análise
Proteínas Proto-Oncogênicas c-fos/biossíntese
Protoveratrinas/farmacologia
Reflexo
Medula Espinal/efeitos dos fármacos
Vômito/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Gs] Símbolo de gene:c-fos
[Nm] Nome de substância:
0 (Emetics); 0 (Proto-Oncogene Proteins c-fos); 0 (Protoveratrines); 36B82AMQ7N (Naloxone); D0P25S3P81 (Lobeline); N21FAR7B4S (Apomorphine); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:9403
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:940201
[St] Status:MEDLINE


  5 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2373197
[Au] Autor:Bertolini A; Ferrari W; Guarini S; Tagliavini S
[Ad] Endereço:Institute of Pharmacology, University of Modena, Italy.
[Ti] Título:Circulatory and respiratory consequences of massive hemorrhage are reversed by protoveratrines.
[So] Source:Experientia;46(7):704-8, 1990 Jul 15.
[Is] ISSN:0014-4754
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In a rat model of severe hypotension and respiratory depression induced by step-wise bleeding, protoveratrines cause a prompt and sustained improvement of cardiovascular and respiratory functions, both in anesthetized and in conscious animals, seemingly through a magnification of the reflex response originated by the chemoreceptors of aortic and carotid bodies. The restoration of cardiovascular function is attributable to an increase both in total peripheral resistance and cardiac output. The finding could provide the basis for a new approach to the first-aid management of massive blood losses.
[Mh] Termos MeSH primário: Protoveratrinas/uso terapêutico
Choque/tratamento farmacológico
Alcaloides de Veratrum/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea/efeitos dos fármacos
Corpo Carotídeo/fisiologia
Feminino
Hipotensão/tratamento farmacológico
Masculino
Ratos
Ratos Endogâmicos
Análise de Sobrevida
Vagotomia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Protoveratrines); 0 (Veratrum Alkaloids)
[Em] Mês de entrada:9008
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900715
[St] Status:MEDLINE


  6 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:1691369
[Au] Autor:Muller B; Lugnier C; Stoclet JC
[Ad] Endereço:Laboratoire de Pharmacologie Cellulaire et Moléculaire, Université Louis Pasteur de Strasbourg, Illkirch, France.
[Ti] Título:Implication of cyclic AMP in the positive inotropic effects of cyclic GMP-inhibited cyclic AMP phosphodiesterase inhibitors on guinea pig isolated left atria.
[So] Source:J Cardiovasc Pharmacol;15(3):444-51, 1990 Mar.
[Is] ISSN:0160-2446
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present investigation was performed to characterize the positive inotropic actions of inhibitors of the cyclic GMP-inhibited cyclic AMP phosphodiesterase (CGI-PDE) on the electrically driven guinea pig left atria. With forskolin added at a concentration (1 x 10(-8)-3 x 10(-8) M) that in itself produced a 10.7% increase of the response to electrical stimulation, the EC50 value of isoproterenol was slightly but significantly (p less than 0.01) reduced from 1.5 to 0.9 nM without modification of the maximal developed tension (delta Emax). The positive inotropic effects of milrinone, piroximone, and SK&F 94120 were significantly enhanced by forskolin (percentage of increase at 3 x 10(-5) M CGI-PDE inhibitors concentration was milrinone 43, piroximone 154, and SK&F 94120 133). With 8-Br-cyclic GMP added (10(-4) M) that in itself exerted a small but significant negative inotropic effect (-0.12 g), the EC50 value of isoproterenol was significantly (p less than 0.01) increased from 1.5 to 3 nM without modification of the delta Emax value. The positive inotropic effects of CGI-PDE inhibitors were significantly depressed by 8-Br-cyclic GMP (percentage of decrease at 3 x 10(-5) M was milrinone 35, piroximone 63, and SK&F 94120 39). In identical conditions, neither forskolin nor 8-Br-cyclic GMP produced any significant alteration of the positive inotropic effects of elevated external Ca2+ or protoveratrine B. Together these results strongly suggest that the positive inotropic effect of CGI-PDE inhibitors is mediated by cyclic AMP in guinea pig left atria.(ABSTRACT TRUNCATED AT 250 WORDS)
[Mh] Termos MeSH primário: 3´,5´-AMP Cíclico Fosfodiesterases/antagonistas & inibidores
AMP Cíclico/metabolismo
GMP Cíclico/farmacologia
Contração Miocárdica/efeitos dos fármacos
Miocárdio/enzimologia
[Mh] Termos MeSH secundário: 8-Bromo Monofosfato de Adenosina Cíclica/farmacologia
Animais
Cloreto de Cálcio/farmacologia
Cardiotônicos/farmacologia
Colforsina/farmacologia
Cobaias
Imidazóis/farmacologia
Técnicas In Vitro
Isoproterenol/farmacologia
Masculino
Milrinona
Protoveratrinas/farmacologia
Pirazinas/farmacologia
Piridonas/farmacologia
Sódio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cardiotonic Agents); 0 (Imidazoles); 0 (Protoveratrines); 0 (Pyrazines); 0 (Pyridones); 1F7A44V6OU (Colforsin); 23583-48-4 (8-Bromo Cyclic Adenosine Monophosphate); 2VSD0380YB (piroximone); 89541-55-9 (5-(4-acetamidophenyl)pyrazin-2(1H)-one); 9NEZ333N27 (Sodium); E0399OZS9N (Cyclic AMP); EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases); H2D2X058MU (Cyclic GMP); JU9YAX04C7 (Milrinone); L628TT009W (Isoproterenol); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:9005
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900301
[St] Status:MEDLINE


  7 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:2568416
[Au] Autor:Smith WL; Alphin RS; Jackson CB; Sancilio LF
[Ad] Endereço:Department of Pharmacology, A. H. Robins Company, Inc., Richmond, VA 23261-6609.
[Ti] Título:The antiemetic profile of zacopride.
[So] Source:J Pharm Pharmacol;41(2):101-5, 1989 Feb.
[Is] ISSN:0022-3573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The antiemetic activity of zacopride against a variety of emetogenic agents has been determined in dogs. Zacopride was highly effective in inhibiting emesis due to a wide range of cancer chemotherapeutic agents, particularly cisplatin. It was well absorbed orally since the dose of zacopride required to inhibit cisplatin-induced emesis in dogs by 90% was 28 micrograms kg-1 both by i.v. and p.o. routes. Further, zacopride (1 mg kg-1 p.o.), administered after the onset of cisplatin-induced emesis, reduced the number of subsequent emetic episodes by 91%. Zacopride at 0.1, 1, or 3.16 mg kg-1 p.o. or i.v., reduced the number of emetic episodes due to dacarbazine, mechlorethamine, adriamycin, actinomycin D, or peptide YY by 100, 100, 86, 96 and 79%, respectively. However, zacopride was not effective in inhibiting emesis due to either apomorphine, copper sulphate, protoveratrine A, histamine, or pilocarpine. No adverse effects attributed to zacopride were observed. Zacopride is thus a unique and potent antiemetic agent as it selectively inhibits the emetic response to cancer chemotherapy agents and peptide YY.
[Mh] Termos MeSH primário: Antieméticos/farmacologia
Benzamidas/farmacologia
Compostos Bicíclicos Heterocíclicos com Pontes
Compostos Bicíclicos com Pontes/farmacologia
Hidrocarbonetos Aromáticos com Pontes/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/antagonistas & inibidores
Apomorfina/antagonistas & inibidores
Cobre/antagonistas & inibidores
Sulfato de Cobre
Cães
Feminino
Antagonistas dos Receptores Histamínicos
Masculino
Peptídeo YY
Peptídeos/antagonistas & inibidores
Pilocarpina/antagonistas & inibidores
Protoveratrinas/antagonistas & inibidores
Vômito/induzido quimicamente
Vômito/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiemetics); 0 (Antineoplastic Agents); 0 (Benzamides); 0 (Bridged Bicyclo Compounds); 0 (Bridged Bicyclo Compounds, Heterocyclic); 0 (Bridged-Ring Compounds); 0 (Histamine Antagonists); 0 (Peptides); 0 (Protoveratrines); 01MI4Q9DI3 (Pilocarpine); 106388-42-5 (Peptide YY); 789U1901C5 (Copper); 9GN3OT4156 (zacopride); LRX7AJ16DT (Copper Sulfate); N21FAR7B4S (Apomorphine)
[Em] Mês de entrada:8908
[Cu] Atualização por classe:161123
[Lr] Data última revisão:
161123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:890201
[St] Status:MEDLINE


  8 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:3396627
[Au] Autor:Velly J; Grima M; Decker N; Cragoe EJ; Schwartz J
[Ad] Endereço:Institut de Pharmacologie (UA 589 CNRS) Faculté de Médecine, Strasbourg, France.
[Ti] Título:Effects of amiloride and its analogues on [3H]batrachotoxinin-A 20-alpha benzoate binding, [3H]tetracaine binding and 22Na influx.
[So] Source:Eur J Pharmacol;149(1-2):97-105, 1988 Apr 27.
[Is] ISSN:0014-2999
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ability of amiloride and its analogues to inhibit [3H]batrachotoxinin-A 20-alpha benzoate [( 3H]BTX-B) and [3H]tetracaine binding to rat synaptosomes and to a rat heart membrane preparation was tested. Their ability to inhibit 22Na influx was determined with rat synaptosomes. 5-N-substituted analogues were generally more potent in inhibiting [3H]BTX-B and [3H]tetracaine binding than compounds substituted on the guanidine group. However, the inhibition was not competitive. Amiloride and some of its analogues were as active or more active in inhibiting [3H]tetracaine binding than they were in inhibiting [3H]BTX-B binding. 22Na influx was inhibited with the same relative potencies as [3H]BTX-B binding and a good correlation was found between the two inhibitions. These results show an effect of amiloride and its analogues on the voltage-sensitive Na+ channels, which could partly explain the inotropic effects of these drugs.
[Mh] Termos MeSH primário: Amilorida/farmacologia
Batraquiotoxinas/metabolismo
Neurotoxinas/metabolismo
Sódio/metabolismo
Tetracaína/metabolismo
[Mh] Termos MeSH secundário: Amilorida/análogos & derivados
Animais
Ligação Competitiva/efeitos dos fármacos
Técnicas In Vitro
Miocárdio/metabolismo
Protoveratrinas/farmacologia
Ratos
Radioisótopos de Sódio
Sinaptossomos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Batrachotoxins); 0 (Neurotoxins); 0 (Protoveratrines); 0 (Sodium Radioisotopes); 0619F35CGV (Tetracaine); 78870-19-6 (batrachotoxinin A 20-alpha-benzoate); 7DZO8EB0Z3 (Amiloride); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:8808
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880427
[St] Status:MEDLINE


  9 / 83 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:3366174
[Au] Autor:Grima M; Velly J; Decker N; Marciniak G; Schwartz J
[Ad] Endereço:Laboratoire de Pharmacologie Cardiovasculaire et Rénale, UA 589 CNRS, Faculté de Médecine, Strasbourg, France.
[Ti] Título:Inhibitory effects of some cyclohexylaralkylamines related to perhexiline on sodium influx, binding of [3H]batrachotoxinin A 20-alpha-benzoate and [3H]nitrendipine and on guinea pig left atria contractions.
[So] Source:Eur J Pharmacol;147(2):173-85, 1988 Mar 01.
[Is] ISSN:0014-2999
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The antagonist activities of some cyclohexylaralkylamines derived from perhexiline on the fast Na+ channel and slow Ca2+ channel in rat brain and rat heart were examined and compared to the antagonist activities of nifedipine, verapamil, prenylamine and perhexiline. Prenylamine, perhexiline and the cyclohexylaralkylamine derivatives inhibited the [3H]batrachotoxinin A 20-alpha-benzoate binding more than the [3H]nitrendipine binding in rat brain. The nature of the interaction of the cyclohexylaralkylamines with the binding of [3H]batrachotoxinin and [3H]nitrendipine was non-competitive. The synaptosomal 22Na uptake induced by protoveratrine B, a Na+ channel agonist, was also inhibited. Prenylamine, perhexiline and perhexiline derivatives were more potent on the fast Na+ channel than on the Ca2+ channel in contrast to nifedipine and verapamil. The inhibition of Na+ and Ca2+ channels was also shown in guinea pig left atria. Perhexiline, prenylamine and the perhexiline derivatives inhibited the protoveratrine B-induced contraction more than they inhibited that induced by CaCl2, in contrast with nifedipine and verapamil. Our results showed that prenylamine, perhexiline and its related cyclohexylaralkylamines inhibited the fast Na+ channel far more than the slow Ca2+ channel in rat brain, rat heart and guinea pig atria.
[Mh] Termos MeSH primário: Batraquiotoxinas/metabolismo
Bloqueadores dos Canais de Cálcio/metabolismo
Nitrendipino/metabolismo
Perexilina/análogos & derivados
Perexilina/farmacologia
Sódio/metabolismo
[Mh] Termos MeSH secundário: Animais
Ligação Competitiva/efeitos dos fármacos
Cloreto de Cálcio/farmacologia
Cobaias
Técnicas In Vitro
Masculino
Contração Miocárdica/efeitos dos fármacos
Protoveratrinas/farmacologia
Ratos
Ratos Endogâmicos
Radioisótopos de Sódio
Sinaptossomos/efeitos dos fármacos
Sinaptossomos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Batrachotoxins); 0 (Calcium Channel Blockers); 0 (Protoveratrines); 0 (Sodium Radioisotopes); 78870-19-6 (batrachotoxinin A 20-alpha-benzoate); 9B627AW319 (Nitrendipine); 9NEZ333N27 (Sodium); KU65374X44 (Perhexiline); M4I0D6VV5M (Calcium Chloride)
[Em] Mês de entrada:8806
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880301
[St] Status:MEDLINE


  10 / 83 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:3364609
[Au] Autor:Hasser EM; DiCarlo SE; Applegate RJ; Bishop VS
[Ad] Endereço:Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284-7764.
[Ti] Título:Osmotically released vasopressin augments cardiopulmonary reflex inhibition of the circulation.
[So] Source:Am J Physiol;254(5 Pt 2):R815-20, 1988 May.
[Is] ISSN:0002-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exogenous arginine vasopressin (AVP) has been shown to augment the inhibitory influence of arterial and cardiopulmonary baroreflexes. This study examined the influence of osmotically released AVP on the inhibitory responses to activation of cardiopulmonary receptors by administration of veratrum alkaloids. Three groups of conscious dogs, with carotid sinus intact, with prior sinoaortic denervation (SAD), and with prior lesion of the area postrema (AP), were instrumented for monitoring arterial pressure and heart rate and with left circumflex coronary artery or left atrial catheters for administration of veratrum alkaloids. Conscious dogs were administered veratridine (0.5-1.0 microgram.kg-1.min-1) under control conditions, after infusion of hypertonic saline (HS, 6% NaCl), and after HS in the presence of the AVP vascular (V1) receptor antagonist. In carotid sinus-intact dogs, veratridine reduced arterial pressure (-10 +/- 0.4 mmHg). After HS infusion, the depressor response to veratridine was significantly greater (-18 +/- 0.8 mmHg). The enhanced depressor response during HS infusion was prevented by administration of the AVP antagonist (-8 +/- 0.6 mmHg). Responses to veratrum alkaloids in SAD dogs were similar. In AP-lesioned animals, the depressor effects of veratridine (-9 +/- 0.5 mmHg) were similar to intact animals. However, the response to veratridine during HS was not altered (-9 +/- 0.8 mmHg) in AP-lesioned dogs. Results suggest that osmotically stimulated AVP augments the inhibitory effects of cardiopulmonary reflexes and that this effect is mediated through the area postrema via the V1 receptor.
[Mh] Termos MeSH primário: Arginina Vasopressina/sangue
Fenômenos Fisiológicos Cardiovasculares
Coração/fisiologia
Pulmão/fisiologia
Reflexo/fisiologia
[Mh] Termos MeSH secundário: Animais
Seio Carotídeo/fisiologia
Denervação
Cães
Coração/efeitos dos fármacos
Bulbo/fisiologia
Pressorreceptores/fisiologia
Protoveratrinas/farmacologia
Valores de Referência
Solução Salina Hipertônica/farmacologia
Nó Sinoatrial/fisiologia
Veratridina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Protoveratrines); 0 (Saline Solution, Hypertonic); 113-79-1 (Arginine Vasopressin); 71-62-5 (Veratridine)
[Em] Mês de entrada:8806
[Cu] Atualização por classe:081121
[Lr] Data última revisão:
081121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:880501
[St] Status:MEDLINE



página 1 de 9 ir para página                      
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde