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[PMID]: 28817686 [Au] Autor: Chen SP; Singh K; Lin SC [Ad] Endereço: Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, United States of America. [Ti] Título: Use of phosphodiesterase inhibitors and prevalence of self-reported glaucoma in the United States. [So] Source: PLoS One;12(8):e0183388, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: OBJECTIVE: While decreased ocular blood flow is thought to be a possible contributor to glaucoma pathogenesis, it is unclear what role systemic phosphodiesterase inhibitors (PDEi) play. We performed a cross-sectional study of a nationally representative sample of the U.S. population to investigate the relationship between the most commonly used PDEi, sildenafil and theophylline, and self-reported glaucoma. METHODS: We used the National Health and Nutrition Examination Survey 2005-2008 cycles for this observational study. 7,042 participants, aged 40 years and over, responded to a survey item on glaucoma status and were included in the analysis. Multivariable logistic regression models were constructed to evaluate the association between at least 1 year of self-reported PDEi use and prevalent glaucoma. Regressions were adjusted for potential confounding variables, including demographics, socioeconomic status, and general health conditions, and accounted for the complex design of the survey. Sample weights were constructed and used to ensure the generalizability of results. RESULTS: 482 respondents self-reported a diagnosis of glaucoma, of which 11 used sildenafil and 20 used theophylline for at least 1 year. Covariates significantly associated with higher odds of glaucoma prevalence in univariable analyses included older age, black race, former smoking status, diabetes, hyperlipidemia, myocardial infarction, and stroke. Conversely, higher education and income were significantly associated with lower odds of glaucoma prevalence. In regression analyses adjusted for demographic and socioeconomic variables, sildenafil (OR = 4.90, CI: 1.24-19.27, p = 0.025) and theophylline (OR = 3.15, CI: 1.46-6.80, p = 0.005) were significantly associated with higher odds of self-reported glaucoma. These associations held after further adjustment with general health behaviors and conditions for both sildenafil and theophylline. CONCLUSIONS: Use of sildenafil and theophylline for one or more years was associated with greater prevalence of self-reported glaucoma, a finding which requires further prospective study to assess causality and possible mechanisms of action. [Mh] Termos MeSH primário: Glaucoma/induzido quimicamente Inibidores de Fosfodiesterase/efeitos adversos [Mh] Termos MeSH secundário: Idoso Estudos Transversais Feminino Seres Humanos Masculino Meia-Idade Citrato de Sildenafila/efeitos adversos Teofilina/efeitos adversos Estados Unidos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Phosphodiesterase Inhibitors); BW9B0ZE037 (Sildenafil Citrate); C137DTR5RG (Theophylline) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171013 [Lr] Data última revisão: 171013 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170818 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0183388

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[PMID]: 28775001 [Au] Autor: Nigwekar SU; Weiser JM; Kalim S; Xu D; Wibecan JL; Dougherty SM; Mercier-Lafond L; Corapi KM; Eneanya ND; Holbrook EH; Brown D; Thadhani RI; Paunescu TG [Ad] Endereço: Division of Nephrology, Department of Medicine, and Paunescu.Teodor@mgh.harvard.edu snigwekar@mgh.harvard.edu. [Ti] Título: Characterization and Correction of Olfactory Deficits in Kidney Disease. [So] Source: J Am Soc Nephrol;28(11):3395-3403, 2017 Nov. [Is] ISSN: 1533-3450 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Patients with CKD suffer from food aversion, anorexia, and malnutrition. Although olfaction has a significant role in determining food flavor, our understanding of olfactory impairment and of the olfaction-nutrition axis in patients with kidney disease is limited. We quantified odor identification, odor threshold, and subjective odor perception in a cohort ( =161) comprising 36 participants with CKD, 100 participants with ESRD, and 25 controls. We investigated olfaction-nutrition associations in these participants and examined a novel intervention to improve olfaction in ESRD. The mean odor identification score was lower in patients with CKD (75.6%±13.1%; =0.02) and ESRD (66.8%±15.1%; <0.001) than in controls (83.6%±11.4%). Patients with ESRD exhibited higher odor threshold than the remaining participants exhibited. All groups had similar scores for subjective smell assessment. In multivariable adjusted analyses, kidney disease associated with increased odds of odor identification deficits (odds ratio, 4.80; 95% confidence interval, 1.94 to 11.89). A reduction in odor identification score was associated with higher subjective global assessment score and lower serum total cholesterol, LDL cholesterol, and albumin concentrations. We found no associations between odor threshold and nutritional parameters. In a proof of concept, 6-week, open-label clinical trial, intranasal theophylline (an epithelial membrane transport and proton secretion activator) increased odor identification score in five out of seven (71%) patients with ESRD. In conclusion, patients with kidney disease have olfactory deficits that may influence their nutritional status. Our preliminary results regarding olfactory improvement using intranasal theophylline warrant confirmation in a randomized controlled trial. [Mh] Termos MeSH primário: Transtornos do Olfato/etiologia Insuficiência Renal Crônica/complicações [Mh] Termos MeSH secundário: Feminino Seres Humanos Falência Renal Crônica/complicações Masculino Meia-Idade Transtornos do Olfato/tratamento farmacológico Transtornos do Olfato/fisiopatologia Inibidores de Fosfodiesterase/uso terapêutico Teofilina/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Phosphodiesterase Inhibitors); C137DTR5RG (Theophylline) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170805 [St] Status: MEDLINE [do] DOI: 10.1681/ASN.2016121308

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[PMID]: 28602874 [Au] Autor: Pineton de Chambrun M; Gousseff M; Mauhin W; Lega JC; Lambert M; Rivière S; Dossier A; Ruivard M; Lhote F; Blaison G; Alric L; Agard C; Saadoun D; Graveleau J; Soubrier M; Lucchini-Lecomte MJ; Christides C; Bosseray A; Levesque H; Viallard JF; Tieulie N; Lovey PY; Le Moal S; Bibes B; Malizia G; Abgueguen P; Lifermann F; Ninet J; Hatron PY; Amoura Z; EurêClark Study Group [Ad] Endereço: Service de médecine interne 2, CHU La Pitié-Salpêtrière, APHP, Université Paris 6, France; Service de réanimation médicale, CHU La Pitié-Salpêtrière, APHP, Université Paris 6, France. [Ti] Título: Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. [So] Source: Am J Med;130(10):1219.e19-1219.e27, 2017 Oct. [Is] ISSN: 1555-7162 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Monoclonal gammopathy-associated systemic capillary-leak syndrome, also known as Clarkson disease, is a rare condition characterized by recurrent life-threatening episodes of capillary hyperpermeability in the context of a monoclonal gammopathy. This study was conducted to better describe the clinical characteristics, natural history, and long-term outcome of monoclonal gammopathy-associated systemic capillary-leak syndrome. METHODS: We conducted a cohort analysis of all patients included in the European Clarkson disease (EurêClark) registry between January 1997 and March 2016. From diagnosis to last follow-up, studied outcomes (eg, the frequency and severity of attacks, death, and evolution toward multiple myeloma) and the type of preventive treatments administered were monitored every 6 months. RESULTS: Sixty-nine patients (M/F sex ratio 1:1; mean ± SD age at disease onset 52 ± 12 years) were included in the study. All patients had monoclonal gammopathy of immunoglobulin G type, with kappa light chains in 47 (68%). Median (interquartile range) follow-up duration was 5.1 (2.5-9.7) years. Twenty-four patients (35%) died after 3.3 (0.9-8) years. Fifty-seven (86%) patients received at least one preventive treatment, including intravenous immunoglobulins (IVIg) n = 48 (73.8%), theophylline n = 22 (33.8%), terbutaline n = 22 (33.8%), and thalidomide n = 5 (7.7%). In the 65 patients with follow-up, 5- and 10-year survival rates were 78% (n = 35) and 69% (n = 17), respectively. Multivariate analysis found preventive treatment with IVIg (hazard ratio 0.27; 95% confidence interval, 0.10-0.70; P = .007) and terbutaline (hazard ratio 0.35; 95% confidence interval, 0.13-0.96; P = .041) to be independent predictors of mortality. CONCLUSIONS: We describe the largest cohort to date of patients with well-defined monoclonal gammopathy-associated systemic capillary-leak syndrome. Preventive treatment with IVIg was the strongest factor associated with survival, suggesting the use of IVIg as the first line in prevention therapy. [Mh] Termos MeSH primário: Síndrome de Vazamento Capilar/tratamento farmacológico Imunoglobulinas Intravenosas/uso terapêutico Paraproteinemias/diagnóstico por imagem [Mh] Termos MeSH secundário: Síndrome de Vazamento Capilar/etiologia Síndrome de Vazamento Capilar/mortalidade Síndrome de Vazamento Capilar/patologia Feminino Seres Humanos Masculino Meia-Idade Paraproteinemias/complicações Paraproteinemias/mortalidade Paraproteinemias/patologia Análise de Sobrevida Terbutalina/uso terapêutico Teofilina/uso terapêutico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Immunoglobulins, Intravenous); C137DTR5RG (Theophylline); N8ONU3L3PG (Terbutaline) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170922 [Lr] Data última revisão: 170922 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 170613 [St] Status: MEDLINE

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[PMID]: 28445845 [Au] Autor: Mináriková M; Fojtikova V; Vyskocilová E; Sedlácek J; Sikut M; Borek-Dohalska L; Stiborová M; Martinkova M [Ad] Endereço: Department of Biochemistry, Faculty of Science, Charles University, Hlavova (Albertov) 2030-8, Prague 2, Czech Republic. [Ti] Título: The capacity and effectiveness of diosmectite and charcoal in trapping the compounds causing the most frequent intoxications in acute medicine: A comparative study. [So] Source: Environ Toxicol Pharmacol;52:214-220, 2017 Jun. [Is] ISSN: 1872-7077 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The aim of the study was to compare the adsorption ability of two adsorbent materials, namely diosmectite and activated charcoal towards selected model compounds that are most commonly involved in acute intoxication. Eleven model compounds were selected: acetylsalicylic acid, α-amanitin, amlodipine, digoxin, phenobarbital, ibuprofen, imipramine, carbamazepine, oxazepam, promethazine, and theophylline. Of the tested compounds, promethazine and imipramine were the most effectively adsorbed to diosmectite. Their adsorption to diosmectite (0.356±0.029mg promethazine/mg diosmectite and 0.354±0.019mg imipramine/mg diosmectite, respectively) was significantly higher than their adsorption to activated charcoal. The effect of temperature and pH on the adsorption efficiencies was also evaluated. In the case of experiments with mixture of both adsorbents, they mostly behaved in a solution independently or in a slightly antagonistic way. Using various methods such as N adsorption and thermogravimetric analysis, the structure and texture of diosmectite and activated charcoal were attained. [Mh] Termos MeSH primário: Antídotos/química Carvão Vegetal/química Envenenamento/prevenção & controle Silicatos/química [Mh] Termos MeSH secundário: Adsorção Alfa-Amanitina/química Anlodipino/química Aspirina/química Carbamazepina/química Digoxina/química Ibuprofeno/química Imipramina/química Oxazepam/química Fenobarbital/química Prometazina/química Teofilina/química [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alpha-Amanitin); 0 (Antidotes); 0 (Silicates); 16291-96-6 (Charcoal); 1J444QC288 (Amlodipine); 33CM23913M (Carbamazepine); 6GOW6DWN2A (Oxazepam); 73K4184T59 (Digoxin); A3N5ZCN45C (Smectite); C137DTR5RG (Theophylline); FF28EJQ494 (Promethazine); OGG85SX4E4 (Imipramine); R16CO5Y76E (Aspirin); WK2XYI10QM (Ibuprofen); YQE403BP4D (Phenobarbital) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170427 [St] Status: MEDLINE

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[PMID]: 28437473 [Au] Autor: Warfield BM; Anderson PC [Ad] Endereço: Department of Physical Sciences, University of Washington, Bothell, Washington, United States of America. [Ti] Título: Molecular simulations and Markov state modeling reveal the structural diversity and dynamics of a theophylline-binding RNA aptamer in its unbound state. [So] Source: PLoS One;12(4):e0176229, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RNA aptamers are oligonucleotides that bind with high specificity and affinity to target ligands. In the absence of bound ligand, secondary structures of RNA aptamers are generally stable, but single-stranded and loop regions, including ligand binding sites, lack defined structures and exist as ensembles of conformations. For example, the well-characterized theophylline-binding aptamer forms a highly stable binding site when bound to theophylline, but the binding site is unstable and disordered when theophylline is absent. Experimental methods have not revealed at atomic resolution the conformations that the theophylline aptamer explores in its unbound state. Consequently, in the present study we applied 21 microseconds of molecular dynamics simulations to structurally characterize the ensemble of conformations that the aptamer adopts in the absence of theophylline. Moreover, we apply Markov state modeling to predict the kinetics of transitions between unbound conformational states. Our simulation results agree with experimental observations that the theophylline binding site is found in many distinct binding-incompetent states and show that these states lack a binding pocket that can accommodate theophylline. The binding-incompetent states interconvert with binding-competent states through structural rearrangement of the binding site on the nanosecond to microsecond timescale. Moreover, we have simulated the complete theophylline binding pathway. Our binding simulations supplement prior experimental observations of slow theophylline binding kinetics by showing that the binding site must undergo a large conformational rearrangement after the aptamer and theophylline form an initial complex, most notably, a major rearrangement of the C27 base from a buried to solvent-exposed orientation. Theophylline appears to bind by a combination of conformational selection and induced fit mechanisms. Finally, our modeling indicates that when Mg2+ ions are present the population of binding-competent aptamer states increases more than twofold. This population change, rather than direct interactions between Mg2+ and theophylline, accounts for altered theophylline binding kinetics. [Mh] Termos MeSH primário: Aptâmeros de Nucleotídeos/metabolismo Simulação de Dinâmica Molecular Teofilina/química [Mh] Termos MeSH secundário: Sítios de Ligação Magnésio/química Cadeias de Markov [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aptamers, Nucleotide); C137DTR5RG (Theophylline); I38ZP9992A (Magnesium) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170906 [Lr] Data última revisão: 170906 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170425 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0176229

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[PMID]: 28377163 [Au] Autor: Qu Q; Xuan H; Zhang K; Chen X; Sun S; Ding Y; Feng S; Xu Q [Ad] Endereço: Key Laboratory of Functional Molecule Design and Interface Process, School of Materials and Chemical Engineering, Anhui Jianzhu University, Hefei 230601, China. Electronic address: quqishu@qq.com. [Ti] Título: Rods-on-sphere silica particles for high performance liquid chromatography. [So] Source: J Chromatogr A;1497:87-91, 2017 May 12. [Is] ISSN: 1873-3778 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Silica spheres covered with rods perpendicular to the particle surface were prepared by a simple one-pot sol-gel process. Thus prepared rods-on-sphere silica particles possessed core-shell structure. Compared to other core-shell silica particles in which the shell was synthesized by the time-consuming multiple-step layer-by-layer coating technique, the shell of our rods-on-sphere particles was formed by directly grown rods from the silica spheres. The coverage of the rods on the particle surface could be tuned by changing the amount of water in the reaction. The rods on the particle surface increased the surface roughness which may help decreasing the A-term. Therefore, the calcined and modified rods-on-sphere silica particles were packed into stainless steel columns and then assessed for the separation of various samples including small molecules and proteins. In comparison with a commercially available Kromasil column, the pressure of the rods-on-sphere column is much lower under the same separation conditions, while the column efficiency was comparable. The separation results demonstrate that rods-on-sphere silica particles are a type of new and highly promising packing stationary phase for high performance liquid chromatography. [Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos Dióxido de Silício/química [Mh] Termos MeSH secundário: Compostos de Anilina/análise Compostos de Anilina/isolamento & purificação Clorobenzenos/análise Clorobenzenos/isolamento & purificação Naftalenos/análise Naftalenos/isolamento & purificação Tamanho da Partícula Proteínas/química Proteínas/isolamento & purificação Propriedades de Superfície Teofilina/análise Teofilina/isolamento & purificação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Aniline Compounds); 0 (Chlorobenzenes); 0 (Naphthalenes); 0 (Proteins); 2166IN72UN (naphthalene); 29757-24-2 (nitroaniline); 6PJ93I88XL (2-dichlorobenzene); 7631-86-9 (Silicon Dioxide); C137DTR5RG (Theophylline) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170516 [Lr] Data última revisão: 170516 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170406 [St] Status: MEDLINE

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[PMID]: 28339843 [Au] Autor: Bouchard J; Lavergne V; Roberts DM; Cormier M; Morissette G; Ghannoum M [Ad] Endereço: Department of Medicine, Hopital du Sacré-Coeur de Montréal, Montreal, Canada. [Ti] Título: Availability and cost of extracorporeal treatments for poisonings and other emergency indications: a worldwide survey. [So] Source: Nephrol Dial Transplant;32(4):699-706, 2017 Apr 01. [Is] ISSN: 1460-2385 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Background: Extracorporeal treatments (ECTRs) are used for different conditions, including replacement of organ function and poisoning. Current recommendations for ECTRs in various poisonings suggest that intermittent haemodialysis (IHD) is the most efficient technique. However, the practicality of these recommendations is poorly defined in view of limited information on availability and cost worldwide. Methods: A survey invitation to an Internet-based questionnaire was emailed between January 2014 and March 2015 to members of international societies to determine the availability, time to initiation and cost of ECTRs (including filters, dialysate, catheter, anticoagulant and nursing/physician salary). The median cost ratio of every ECTR compared with IHD performed in the same institution were presented. Results: The view rate was estimated at 28.1% (2532/9000), the participation rate was 40.1% (1015/2532) and the completion rate was 16.0% (162/1015). Respondents originated from 89 countries, and nearly three-fourths practiced in a tertiary care centre. A total of 162 respondents provided sufficient data for in-depth analysis. IHD was the most available acute ECTR (96.9%), followed by therapeutic plasma exchange (TPE; 68.3%), continuous renal replacement therapy (CRRT; 62.9%), peritoneal dialysis (PD; 44.8%), haemoperfusion (HP; 30.9%) and liver support devices (LSDs; 14.7%). IHD, CRRT and HP were the shortest to initiate (median = 60 min). The median cost ratios of each ECTR compared with IHD were 1.7 for CRRT and HP, 2.8 for TPE, 6.5 for LSDs and 1.4 for PD (P < 0.001 for all). The median cost ratio of a 4-h IHD treatment compared with 1 day in the intensive care unit was 0.6 (P = 0.2). Conclusions: IHD appears to be the most widely available ECTR worldwide and is at least 30% less expensive than other ECTRs. The superior efficacy of IHD for enhanced elimination, added to its lower cost and wider availability, strengthens its preference as the ECTR of choice in most cases of acute poisoning. Keywords: costing, CRRT, EXTRIP, hemodialysis, hemoperfusion. [Mh] Termos MeSH primário: Lesão Renal Aguda/complicações Envenenamento/economia Envenenamento/terapia Diálise Renal/economia Diálise Renal/utilização Terapia de Substituição Renal/efeitos adversos Teofilina/envenenamento [Mh] Termos MeSH secundário: Análise Custo-Benefício Seres Humanos Unidades de Terapia Intensiva Inquéritos e Questionários Vasodilatadores/envenenamento [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Vasodilator Agents); C137DTR5RG (Theophylline) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170607 [Lr] Data última revisão: 170607 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170325 [St] Status: MEDLINE [do] DOI: 10.1093/ndt/gfw456

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[PMID]: 28333461 [Au] Autor: Heinämäki J; Pirttimaa MM; Alakurtti S; Pitkänen HP; Kanerva H; Hulkko J; Paaver U; Aruväli J; Yliruusi J; Kogermann K [Ad] Endereço: Institute of Pharmacy, Faculty of Medicine, University of Tartu , Nooruse 1, 50411 Tartu, Estonia. [Ti] Título: Suberin Fatty Acids from Outer Birch Bark: Isolation and Physical Material Characterization. [So] Source: J Nat Prod;80(4):916-924, 2017 Apr 28. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The isolation and physical material properties of suberin fatty acids (SFAs) were investigated with special reference to their potential applications as novel pharmaceutical excipients. SFAs were isolated from outer birch bark (OBB) with a new extractive hydrolysis method. The present simplified isolation process resulted in a moderate batch yield and chemical purity of SFAs, but further development is needed for establishing batch-to-batch variation. Cryogenic milling was the method of choice for the particle size reduction of SFAs powder. The cryogenically milled SFAs powder exhibited a semicrystalline structure with apparent microcrystalline domains within an amorphous fatty acids matrix. The thermogravimetric analysis (TGA) of SFAs samples showed a good thermal stability up to 200 °C, followed by a progressive weight loss, reaching a plateau at about 95% volatilization at about 470 °C. The binary blends of SFAs and microcrystalline cellulose (MCC; Avicel PH 101) in a ratio of 25:75 (w/w) displayed good powder flow and tablet compression properties. The corresponding theophylline-containing tablets showed sustained or prolonged-release characteristics. The physicochemical and bulk powder properties of SFAs isolated from OBB are auspicious in terms of potential pharmaceutical excipient applications. [Mh] Termos MeSH primário: Betula/química Ácidos Graxos/isolamento & purificação Lipídeos/isolamento & purificação Lipídeos/farmacologia Casca de Planta/química [Mh] Termos MeSH secundário: Celulose Química Farmacêutica Excipientes/farmacologia Ácidos Graxos/química Lipídeos/química Estrutura Molecular Comprimidos/farmacologia Teofilina/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Excipients); 0 (Fatty Acids); 0 (Lipids); 0 (Tablets); 8072-95-5 (suberin); 9004-34-6 (Cellulose); C137DTR5RG (Theophylline); OP1R32D61U (microcrystalline cellulose) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170801 [Lr] Data última revisão: 170801 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170324 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.6b00771

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[PMID]: 28277853 [Au] Autor: Mennini FS; Sciattella P; Marcellusi A; Marcobelli A; Russo A; Caputi AP [Ad] Endereço: a Economic Evaluation and HTA (EEHTA), CEIS, Faculty of Economics , University of Rome "Tor Vergata" , Rome , Italy. [Ti] Título: Treatment plan comparison in acute and chronic respiratory tract diseases: an observational study of doxophylline vs. theophylline. [So] Source: Expert Rev Pharmacoecon Outcomes Res;17(5):503-510, 2017 Oct. [Is] ISSN: 1744-8379 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: The main objective of this article is to estimate the global cost related to the use of the two drugs (associated drugs, specialist visits, hospital admissions, plasma drug monitoring). METHODS: The drug prescriptions were extracted from the Information System of the Pharmaceutical Prescriptions of the Marche Region for each ATC code in the years 2008-2012 and the number of patients per year and other outcomes measure were obtained. RESULTS: 13,574 patients were treated with theophylline and 19,426 patients with doxophylline. The number of patients treated was approximately 5,000 per year. Co-prescription with other drugs, use of corticosteroids, mean number of visits and hospital admissions (per 100 patients) were lower for doxophylline vs theophylline (1.55vs5.50, 0.3vs0.7, 2.05vs3.73 and 1.57vs3.3 respectively). The annual mean cost per patient was €187.4 for those treated with doxophylline and €513.5 for theophylline. CONCLUSIONS: In our study, doxophylline resulted to be associated with a reduction of the overall cost. [Mh] Termos MeSH primário: Broncodilatadores/uso terapêutico Custos de Cuidados de Saúde Doenças Respiratórias/tratamento farmacológico Teofilina/análogos & derivados [Mh] Termos MeSH secundário: Doença Aguda Corticosteroides/administração & dosagem Idoso Broncodilatadores/economia Doença Crônica Custos de Medicamentos Monitoramento de Medicamentos/economia Feminino Hospitalização/economia Seres Humanos Itália Masculino Meia-Idade Doenças Respiratórias/economia Doenças Respiratórias/fisiopatologia Teofilina/economia Teofilina/uso terapêutico [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Adrenal Cortex Hormones); 0 (Bronchodilator Agents); C137DTR5RG (Theophylline); MPM23GMO7Z (doxofylline) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170310 [St] Status: MEDLINE [do] DOI: 10.1080/14737167.2017.1301815

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[PMID]: 28230296 [Au] Autor: Guterman R; Antonietti M; Yuan J [Ad] Endereço: Department of Colloid Chemistry, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1 OT Golm, D-14476, Potsdam, Germany. [Ti] Título: Plants to Polyelectrolytes: Theophylline Polymers and Their Microsphere Synthesis. [So] Source: Macromol Rapid Commun;38(8), 2017 Apr. [Is] ISSN: 1521-3927 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: To extend fossil oil supplies, sustainable feed stocks for the production of useful reagents and polymers should be harnessed. In this regard, chemicals derived from plants are excellent candidates. While the vast majority of plant sources used for polymer science only contain C H O , alkaloids such as caffeine, nicotine, and theophylline possess nitrogen functionality that can provide new functions for bioderived polymers and their synthesis. In this context, the chemistry of theophylline, a natural product found in chocolate and tea, is exploited to create a cationic "poly(theophylline)" in a straightforward fashion for the first time. This work demonstrates how this new polymer can be synthesized and used for the creation of narrowly disperse cationic microspheres. [Mh] Termos MeSH primário: Microesferas Plantas/química Polieletrólitos/química Polímeros/química Teofilina/química [Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética Microscopia Eletrônica de Varredura Modelos Químicos Estrutura Molecular Tamanho da Partícula Polieletrólitos/síntese química Polímeros/síntese química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Polyelectrolytes); 0 (Polymers); C137DTR5RG (Theophylline) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170601 [Lr] Data última revisão: 170601 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170224 [St] Status: MEDLINE [do] DOI: 10.1002/marc.201600748

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