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[PMID]:29100118
[Au] Autor:Sakalli S; Burkina V; Pilipenko N; Zlabek V; Zamaratskaia G
[Ad] Endereço:Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: sakalli@frov.jcu.cz.
[Ti] Título:In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone.
[So] Source:Chemosphere;192:105-112, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemicals are widely present in fruits, vegetables and other plants and have great health benefits owing to their antioxidant properties. They are naturally found in the aquatic environment as well as discharged from sewage treatment plants after their large consumption. Little is known about their impact on fish; particularly in light of their interactions with pharmaceuticals. Therefore, this study was designed to determine the effects of diosmin, naringenin, quercetin and idole-3-carbinol on CYP1A-dependent 7-ethoxyresorufin-O-deethylase (EROD) activity on rainbow trout hepatic microsomes in the presence of two pharmaceuticals: clotrimazole and dexamethasone. The interactions between the phytochemicals and pharmaceuticals used in this study were determined using a combination index. Hepatic microsomes were exposed to two concentrations (1-or 50 µM) of phytochemicals and pharmaceuticals separately and in combinations. Singly, clotrimazole inhibited EROD activity 40% and 90% of control, while dexamethasone did not. Naringenin and diosmin inhibited EROD activity alone up to 90% and 55% respectively, but activities were further inhibited in the presence of either pharmaceutical. The preliminary study of combinations of clotrimazole with phytochemicals primarily showed synergistic effects. While EROD activity was not inhibited in the presence of quercetin or indole-3-carbinol, significant and synergistic inhibition was detected when either of these was combined with clotrimazole or dexamethasone.
[Mh] Termos MeSH primário: Clotrimazol/química
Citocromo P-450 CYP1A1/química
Dexametasona/química
Diosmina/química
Proteínas de Peixes/química
Flavanonas/química
Indóis/química
Quercetina/química
[Mh] Termos MeSH secundário: Animais
Clotrimazol/farmacologia
Citocromo P-450 CYP1A1/metabolismo
Dexametasona/farmacologia
Diosmina/farmacologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Proteínas de Peixes/metabolismo
Flavanonas/farmacologia
Indóis/farmacologia
Cinética
Fígado/efeitos dos fármacos
Fígado/enzimologia
Microssomos Hepáticos/efeitos dos fármacos
Microssomos Hepáticos/enzimologia
Oncorhynchus mykiss/metabolismo
Quercetina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Fish Proteins); 0 (Flavanones); 0 (Indoles); 7QM776WJ5N (Diosmin); 7S5I7G3JQL (Dexamethasone); 9IKM0I5T1E (Quercetin); C11E72455F (indole-3-carbinol); EC 1.14.14.1 (Cytochrome P-450 CYP1A1); G07GZ97H65 (Clotrimazole); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


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[PMID]:28885366
[Au] Autor:Zhao Z; Bao L; Yu X; Zhu C; Xu J; Wang Y; Yin M; Li Y; Li W
[Ad] Endereço:aDepartment of Infectious Disease, Third Liver Unit bDepartment of Ear-Nose-Throat, Anhui Provincial Hospital, Anhui Medical University, Hefei cDepartment of Infectious Disease, Jiangsu Provincial Hospital, Nanjing Medical University, Nanjing dDepartment of Infectious Disease, Intensive Care Unit, Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
[Ti] Título:Acute vanishing bile duct syndrome after therapy with cephalosporin, metronidazole, and clotrimazole: A case report.
[So] Source:Medicine (Baltimore);96(36):e8009, 2017 Sep.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Vanishing bile duct syndrome (VBDS) consists of a series of diseases characterized by the loss of >50% bile duct in portal areas. Many factors are associated with VBDS including infections, neoplasms, and drugs. Antibiotic is one of the most frequently reported causes of VBDS. PATIENT CONCERNS: A 29-year-old female was admitted because of liver injury for over 3 months. Tests for viruses that can cause hepatitis and autoantibodies were all negative. She was prescribed with antibiotics approximately a week before liver injury while there was no history of alcohol consumption. DIAGNOSES: Liver biopsy demonstrated a loss of intrahepatic bile duct in most of the portal tracts. INTERVENTIONS: This patient was treated with ursodeoxycholic acid, polyene phosphatidylcholine, and bicyclol. Most importantly, the treatments in our hospital were proved by the ethics committee of Department of Infectious Disease, Anhui Provincial Hospital. OUTCOMES: The symptoms were improved. She is still under treatment. LESSONS: VBDS is rare but can be severe. A liver biopsy offers an important evidence for the diagnosis of VBDS, especially for those with a history of susceptible drugs taking.
[Mh] Termos MeSH primário: Antibacterianos/efeitos adversos
Doenças dos Ductos Biliares/induzido quimicamente
Ductos Biliares Intra-Hepáticos/efeitos dos fármacos
Cefalosporinas/efeitos adversos
Clotrimazol/efeitos adversos
Metronidazol/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Doenças dos Ductos Biliares/patologia
Ductos Biliares Intra-Hepáticos/patologia
Cefalosporinas/uso terapêutico
Clotrimazol/uso terapêutico
Quimioterapia Combinada
Feminino
Seres Humanos
Metronidazol/uso terapêutico
Síndrome
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Cephalosporins); 140QMO216E (Metronidazole); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008009


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[PMID]:28490422
[Au] Autor:Jantarajit W; Lertsuwan K; Teerapornpuntakit J; Krishnamra N; Charoenphandhu N
[Ad] Endereço:Center of Calcium and Bone Research, Faculty of Science, Mahidol University, Bangkok, Thailand.
[Ti] Título:CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K channels.
[So] Source:Am J Physiol Cell Physiol;313(1):C118-C129, 2017 Jul 01.
[Is] ISSN:1522-1563
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parathyroid hormone (PTH), a pleiotropic hormone that maintains mineral homeostasis, is also essential for controlling pH balance and ion transport across renal and intestinal epithelia. Optimization of luminal pH is important for absorption of trace elements, e.g., calcium and phosphorus. We have previously demonstrated that PTH rapidly stimulated electrogenic [Formula: see text] secretion in intestinal epithelial-like Caco-2 monolayers, but the underlying cellular mechanism, contributions of other ions, particularly Cl and K , and long-lasting responses are not completely understood. Herein, PTH and forskolin were confirmed to induce anion secretion, which peaked within 1-3 min (early phase), followed by an abrupt decay and plateau that lasted for 60 min (late phase). In both early and late phases, apical membrane capacitance was increased with a decrease in basolateral capacitance after PTH or forskolin exposure. PTH also induced a transient increase in apical conductance with a long-lasting decrease in basolateral conductance. Anion secretion in both phases was reduced under [Formula: see text]-free and/or Cl -free conditions or after exposure to carbonic anhydrase inhibitor (acetazolamide), CFTR inhibitor (CFTRinh-172), Na /H exchanger (NHE)-3 inhibitor (tenapanor), or K channel inhibitors (BaCl , clotrimazole, and TRAM-34; basolateral side), the latter of which suggested that PTH action was dependent on basolateral K recycling. Furthermore, early- and late-phase responses to PTH were diminished by inhibitors of PI3K (wortmannin and LY-294002) and PKA (PKI 14-22). In conclusion, PTH requires NHE3 and basolateral K channels to induce [Formula: see text] and Cl secretion, thus explaining how PTH regulated luminal pH balance and pH-dependent absorption of trace minerals.
[Mh] Termos MeSH primário: Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo
Hormônio Paratireóideo/farmacologia
Fosfatidilinositol 3-Quinases/metabolismo
Canais de Potássio Cálcio-Ativados/metabolismo
ATPase Trocadora de Sódio-Potássio/metabolismo
[Mh] Termos MeSH secundário: Acetazolamida/farmacologia
Potenciais de Ação/efeitos dos fármacos
Androstadienos/farmacologia
Compostos de Bário/farmacologia
Bicarbonatos/metabolismo
Células CACO-2
Cálcio/metabolismo
Inibidores da Anidrase Carbônica/farmacologia
Cloretos/metabolismo
Cloretos/farmacologia
Cromonas/farmacologia
Clotrimazol/farmacologia
Colforsina/farmacologia
Regulador de Condutância Transmembrana em Fibrose Cística/antagonistas & inibidores
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Condutividade Elétrica
Seres Humanos
Concentração de Íons de Hidrogênio
Transporte de Íons/efeitos dos fármacos
Isoquinolinas/farmacologia
Morfolinas/farmacologia
Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Fosfatidilinositol 3-Quinases/genética
Fósforo/metabolismo
Potássio/metabolismo
Canais de Potássio Cálcio-Ativados/antagonistas & inibidores
Canais de Potássio Cálcio-Ativados/genética
Pirazóis/farmacologia
ATPase Trocadora de Sódio-Potássio/antagonistas & inibidores
ATPase Trocadora de Sódio-Potássio/genética
Sulfonamidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstadienes); 0 (Barium Compounds); 0 (Bicarbonates); 0 (CFTR protein, human); 0 (Carbonic Anhydrase Inhibitors); 0 (Chlorides); 0 (Chromones); 0 (Isoquinolines); 0 (Morpholines); 0 (Parathyroid Hormone); 0 (Potassium Channels, Calcium-Activated); 0 (Pyrazoles); 0 (Sulfonamides); 0 (TRAM 34); 0 (tenapanor); 0VK51DA1T2 (barium chloride); 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 1F7A44V6OU (Colforsin); 27YLU75U4W (Phosphorus); 31M2U1DVID (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase); G07GZ97H65 (Clotrimazole); O3FX965V0I (Acetazolamide); RWP5GA015D (Potassium); SY7Q814VUP (Calcium); XVA4O219QW (wortmannin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1152/ajpcell.00010.2017


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[PMID]:28438376
[Au] Autor:Wheat CM; Bickley RJ; Hsueh YH; Cohen BA
[Ad] Endereço:Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: cwheat1@jhmi.edu.
[Ti] Título:Current Trends in the Use of Two Combination Antifungal/Corticosteroid Creams.
[So] Source:J Pediatr;186:192-195.e1, 2017 Jul.
[Is] ISSN:1097-6833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Superficial fungal infections are among the most commonly managed skin problems by general practitioners. Although evidence shows combination antifungal/corticosteroid topicals are more expensive and less effective than single-agent antifungals, practitioners continue to prescribe combination agents. We examined current prescription trends of 2 combination antifungal/corticosteroid medications, Lotrisone and Mycolog-II.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Antifúngicos/uso terapêutico
Betametasona/uso terapêutico
Clotrimazol/uso terapêutico
Dermatomicoses/tratamento farmacológico
Glucocorticoides/uso terapêutico
Gramicidina/uso terapêutico
Neomicina/uso terapêutico
Nistatina/uso terapêutico
Triancinolona Acetonida/uso terapêutico
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Combinação de Medicamentos
Seres Humanos
Lactente
Recém-Nascido
Padrões de Prática Médica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antifungal Agents); 0 (Drug Combinations); 0 (Glucocorticoids); 0 (Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination); 0 (Lotrisone); 1400-61-9 (Nystatin); 1404-04-2 (Neomycin); 1405-97-6 (Gramicidin); 9842X06Q6M (Betamethasone); F446C597KA (Triamcinolone Acetonide); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170426
[St] Status:MEDLINE


  5 / 1603 MEDLINE  
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[PMID]:28346194
[Au] Autor:Agbi KE; Carvalho M; Phan H; Tuma C
[Ad] Endereço:Agbi's Compounding Pharmacy LLC, Pikesville, Maryland. agbiscompoundingpharmacy@yahoo.com.
[Ti] Título:Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications.
[So] Source:Int J Pharm Compd;21(1):22-27, 2017 Jan-Feb.
[Is] ISSN:1092-4221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:An adult diabetic male with three toes amputated on his right foot presented with an ulcer infection on his left foot, unresponsive to conventional antifungal oral medication for over two months. The ulcerated foot wound had a large impairment on the patient's quality of life, as determined by the Wound-QoL questionnaire. The compounding pharmacist recommended and the physician prescribed two topical compounded medicines, which were applied twice a day, free of charge at the compounding pharmacy. The foot ulcer infection was completely resolved following 13 days of treatment, with no longer any impairment on the patient's quality of life. This scientific case study highlights the value of pharmaceutical compounding in current therapeutics, the importance of the triad relationship, and the key role of the compounding pharmacist in diabetes care.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/administração & dosagem
Antifúngicos/administração & dosagem
Pé Diabético/tratamento farmacológico
Vasodilatadores/administração & dosagem
Complexo Vitamínico B/administração & dosagem
Cicatrização/efeitos dos fármacos
Infecção dos Ferimentos/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Cutânea
Anti-Inflamatórios não Esteroides/efeitos adversos
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/economia
Antifúngicos/efeitos adversos
Antifúngicos/química
Antifúngicos/economia
Clotrimazol/administração & dosagem
Redução de Custos
Análise Custo-Benefício
Pé Diabético/diagnóstico
Pé Diabético/economia
Pé Diabético/microbiologia
Combinação de Medicamentos
Composição de Medicamentos
Custos de Medicamentos
Seres Humanos
Ibuprofeno/administração & dosagem
Masculino
Metronidazol/administração & dosagem
Meia-Idade
Nifedipino/administração & dosagem
Ácido Pantotênico/administração & dosagem
Ácido Pantotênico/análogos & derivados
Fatores de Tempo
Resultado do Tratamento
Vasodilatadores/efeitos adversos
Vasodilatadores/química
Vasodilatadores/economia
Complexo Vitamínico B/efeitos adversos
Complexo Vitamínico B/química
Complexo Vitamínico B/economia
Infecção dos Ferimentos/diagnóstico
Infecção dos Ferimentos/economia
Infecção dos Ferimentos/microbiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Antifungal Agents); 0 (Drug Combinations); 0 (Vasodilator Agents); 12001-76-2 (Vitamin B Complex); 140QMO216E (Metronidazole); 19F5HK2737 (Pantothenic Acid); 1O6C93RI7Z (dexpanthenol); G07GZ97H65 (Clotrimazole); I9ZF7L6G2L (Nifedipine); WK2XYI10QM (Ibuprofen)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28301626
[Au] Autor:Lee MA; Cohen PR
[Ti] Título:Zoon Balanitis Revisited: Report of Balanitis Circumscripta Plasmacellularis Resolving With Topical Mupirocin Ointment Monotherapy.
[So] Source:J Drugs Dermatol;16(3):285-287, 2017 Mar 01.
[Is] ISSN:1545-9616
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:

INTRODUCTION: Zoon balanitis is an idiopathic benign inflammatory condition of the glans penis and prepuce. A patient with biopsy confirmed diagnosis of Zoon balanitis who was successfully treated with topical mupirocin ointment monotherapy is described.

METHOD: A search using PubMed database was performed using the following terms: Zoon balanitis (cases, diagnosis, treatment of), balanitis circumscripta plasmacellularis, and mupirocin. Relevant papers and their reference citations were reviewed and evaluated.

RESULTS: The gold standard of treatment for Zoon balanitis has previously been circumcision. More recently, topical calcineurin inhibitors have been shown to be effective. Our patient had successful resolution of his Zoon balanitis after 3 months of mupirocin ointment monotherapy.

DISCUSSION: Zoon balanitis is a benign inflammatory dermatosis. Previous successful treatment modalities include circumcision, phototherapy, laser therapy, and topical calcineurin inhibitors. Topical mupirocin ointment twice daily resulted in resolution of Zoon balanitis in our patient. Additional evaluation of mupirocin ointment as a therapeutic agent should be considered as a potential first-line therapy in patients with Zoon balanitis.

J Drugs Dermatol. 2017;16(3):285-287.

.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Balanite (Inflamação)/diagnóstico
Balanite (Inflamação)/terapia
Mupirocina/uso terapêutico
[Mh] Termos MeSH secundário: Antibacterianos/administração & dosagem
Anti-Infecciosos Locais/uso terapêutico
Balanite (Inflamação)/etiologia
Balanite (Inflamação)/patologia
Biópsia
Inibidores de Calcineurina/uso terapêutico
Circuncisão Masculina
Clotrimazol/administração & dosagem
Clotrimazol/uso terapêutico
Diagnóstico Diferencial
Seres Humanos
Masculino
Meia-Idade
Mupirocina/administração & dosagem
Pomadas
Pênis/patologia
Fototerapia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents, Local); 0 (Calcineurin Inhibitors); 0 (Ointments); D0GX863OA5 (Mupirocin); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE


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[PMID]:28299831
[Au] Autor:Romero-Cerecero O; Islas-Garduño AL; Zamilpa A; Tortoriello J
[Ad] Endereço:Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (CIBIS-IMSS), Xochitepec, Morelos, Mexico.
[Ti] Título:Effectiveness of Ageratina pichinchensis Extract in Patients with Vulvovaginal Candidiasis. A Randomized, Double-Blind, and Controlled Pilot Study.
[So] Source:Phytother Res;31(6):885-890, 2017 Jun.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous clinical studies have demonstrated the antifungal effectiveness of Ageratina pichinchensis extracts when topically administered to patients with dermatomycosis. The objective of this study was to evaluate the effectiveness and tolerability of a 7% standardized extract of A. pichinchensis (intravaginal) in patients with vulvovaginal candidiasis. The extract was standardized in terms of its encecalin content and administered during 6 days to patients with Candida albicans-associated vulvovaginitis. The positive control group was treated with Clotrimazole (100 mg). On day 7 of the study, a partial evaluation was carried out; it demonstrated that 94.1% of patients treated with Clotrimazole and 100% of those treated with the A. pichinchensis extract referred a decrease or absence of signs and symptoms consistent with vulvovaginal candidiasis. In the final evaluation, 2 weeks after concluding administration, 86.6% of patients in the control group and 81.2% (p = 0.65) of those treated with the A. pichinchensis extract demonstrated therapeutic success. Statistical analysis evidenced no significant differences between the two treatment groups. With the results obtained, it is possible to conclude that the standardized extract from A. pichinchensis, intravaginally administered, showed therapeutic and mycological effectiveness, as well as tolerability, in patients with vulvovaginal candidiasis, without noting statistical differences in patients treated with Clotrimazole. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Ageratina/química
Antifúngicos/uso terapêutico
Candidíase Vulvovaginal/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Candida albicans/efeitos dos fármacos
Clotrimazol/uso terapêutico
Método Duplo-Cego
Feminino
Seres Humanos
Fitoterapia/métodos
Projetos Piloto
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5802


  8 / 1603 MEDLINE  
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[PMID]:28280257
[Au] Autor:Liu L; Zhan P; Nie D; Fan L; Lin H; Gao L; Mao X
[Ad] Endereço:Department of Gynaecology and Obstetrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China (mainland).
[Ti] Título:Intermediate-Conductance-Ca2-Activated K Channel IKCa1 Is Upregulated and Promotes Cell Proliferation in Cervical Cancer
[So] Source:Med Sci Monit Basic Res;23:45-57, 2017 03 10.
[Is] ISSN:2325-4416
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Accumulating data point to intermediate-conductance calcium-activated potassium channel (IKCa1) as a key player in controlling cell cycle progression and proliferation of human cancer cells. However, the role that IKCa1 plays in the growth of human cervical cancer cells is largely unexplored. MATERIAL AND METHODS In this study, Western blot analysis, immunohistochemical staining, and RT-PCR were first used for IKCa1protein and gene expression assays in cervical cancer tissues and HeLa cells. Then, IKCa1 channel blocker and siRNA were employed to inhibit the functionality of IKCa1 and downregulate gene expression in HeLa cells, respectively. After these treatments, we examined the level of cell proliferation by MTT method and measured IKCa1 currents by conventional whole-cell patch clamp technique. Cell apoptosis was assessed using the Annexin V-FITC/Propidium Iodide (PI) double-staining apoptosis detection kit. RESULTS We demonstrated that IKCa1 mRNA and protein are preferentially expressed in cervical cancer tissues and HeLa cells. We also showed that the IKCa1 channel blocker, clotrimazole, and IKCa1 channel siRNA can be used to suppress cervical cancer cell proliferation and decrease IKCa1 channel current. IKCa1 downregulation by specific siRNAs induced a significant increase in the proportion of apoptotic cells in HeLa cells. CONCLUSIONS IKCa1 is overexpressed in cervical cancer tissues, and IKCa1 upregulation in cervical cancer cell linea enhances cell proliferation, partly by reducing the proportion of apoptotic cells.
[Mh] Termos MeSH primário: Canais de Potássio Ativados por Cálcio de Condutância Intermediária/metabolismo
Neoplasias do Colo do Útero/metabolismo
Neoplasias do Colo do Útero/patologia
[Mh] Termos MeSH secundário: Adulto
Bloqueadores dos Canais de Cálcio/farmacologia
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Clotrimazol/farmacologia
Feminino
Regulação Neoplásica da Expressão Gênica
Células HeLa
Seres Humanos
Canais de Potássio Ativados por Cálcio de Condutância Intermediária/biossíntese
Canais de Potássio Ativados por Cálcio de Condutância Intermediária/genética
Meia-Idade
Técnicas de Patch-Clamp
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Neoplasias do Colo do Útero/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Calcium Channel Blockers); 0 (Intermediate-Conductance Calcium-Activated Potassium Channels); 0 (KCNN4 protein, human); 0 (RNA, Messenger); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


  9 / 1603 MEDLINE  
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[PMID]:28120351
[Au] Autor:Sepaskhah M; Sadat MS; Pakshir K; Bagheri Z
[Ad] Endereço:Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Comparative efficacy of topical application of tacrolimus and clotrimazole in the treatment of pityriasis versicolor: A single blind, randomised clinical trial.
[So] Source:Mycoses;60(5):338-342, 2017 May.
[Is] ISSN:1439-0507
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pityriasis versicolor (PV) is a common superficial fungal disease. Possibility of emergence of resistant strains to azoles, and difficulty in differentiation of hypopigmented PV and early vitiligo, encouraged us to evaluate the efficacy of topical tacrolimus (a calcineurin inhibitor agent with proven in vitro anti-Malassezia effect) for PV treatment generally and its effect on PV-induced hypopigmentation specifically. OBJECTIVES: To evaluate the efficacy of topical tacrolimus on pityriasis versicolor. PATIENTS/METHODS: Fifty PV patients were randomly allocated into two equal groups applying either topical clotrimazol or tacrolimus twice daily for 3 weeks. They were evaluated at the beginning of study, in the third and fifth weeks clinically and mycologically (direct smear). RESULTS: Although both treatments resulted in global, clinical, and mycological cure of PV, there was no significant difference regarding the mentioned aspects of cure between tacrolimus and clotrimazole treated patients. (P-value: .63, .45, and .26, respectively) Tacrolimus had no significant effect on hypopigmentation in the fifth week follow-up. (P-value: .62). CONCLUSIONS: In spite of the lack of efficacy of tacrolimus on PV-induced hypopigmentation, the therapeutic effect on PV introduces tacrolimus as a therapeutic option for PV, especially when early vitiligo is among the differential diagnoses without concerning the aggravating effect of topical corticosteroids on PV.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/administração & dosagem
Antifúngicos/administração & dosagem
Clotrimazol/administração & dosagem
Pitiríase/tratamento farmacológico
Tacrolimo/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Esquema de Medicação
Feminino
Seres Humanos
Hipopigmentação/tratamento farmacológico
Hipopigmentação/microbiologia
Masculino
Pitiríase/microbiologia
Método Simples-Cego
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Antifungal Agents); G07GZ97H65 (Clotrimazole); WM0HAQ4WNM (Tacrolimus)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1111/myc.12598


  10 / 1603 MEDLINE  
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[PMID]:28117652
[Au] Autor:Hazuchova K; Neiger R; Stengel C
[Ti] Título:Topical treatment of mycotic rhinitis-rhinosinusitis in dogs with meticulous debridement and 1% clotrimazole cream: 64 cases (2007-2014).
[So] Source:J Am Vet Med Assoc;250(3):309-315, 2017 Feb 01.
[Is] ISSN:1943-569X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To evaluate outcomes for dogs with mycotic rhinitis-rhinosinusitis (MRR) treated by meticulous debridement and topical application of 1% clotrimazole cream and investigate potential prognostic factors that could help predict whether 1 or multiple treatments would be needed for clinical resolution of the condition. DESIGN Retrospective case series. ANIMALS 64 dogs. PROCEDURES Medical records were reviewed to identify dogs treated for MRR by meticulous debridement and topical application of 1% clotrimazole cream. Signalment, clinical signs, previous treatments, CT findings, presence of unilateral or bilateral disease, predisposing factors, number and type of treatments, and complications were recorded. Outcome information was obtained from records or by telephone interview with owners. Association of selected factors with the number of treatments needed for clinical resolution was evaluated. RESULTS Clotrimazole was instilled via the trephination site (n = 42) or under endoscopic guidance (22). Thirteen dogs underwent a 5-minute flush with 1% clotrimazole solution prior to cream application, and 34 received adjunctive oral itraconazole treatment. The MRR was deemed resolved in 58 dogs, and clinical signs persisted in 1 dog. Five dogs died (2 of causes unrelated to MRR) ≤ 1 month after treatment. The first treatment was successful in 42 of 62 (68%) dogs; overall success rate was 58 of 62 (94%). No prognostic factors for the number of treatments needed to provide clinical resolution were identified. Seven dogs with reinfection were successfully retreated. CONCLUSIONS AND CLINICAL RELEVANCE Topical treatment by meticulous debridement and 1% clotrimazole cream application had results similar to or better than those described in other studies of dogs with MRR. Trephination or adjunctive itraconazole treatment did not influence the number of treatments needed for a successful outcome.
[Mh] Termos MeSH primário: Clotrimazol/uso terapêutico
Desbridamento/veterinária
Doenças do Cão/terapia
Micoses/veterinária
Rinite/veterinária
Sinusite/veterinária
[Mh] Termos MeSH secundário: Administração Tópica
Animais
Antifúngicos/administração & dosagem
Antifúngicos/uso terapêutico
Clotrimazol/administração & dosagem
Cães
Feminino
Masculino
Micoses/terapia
Estudos Retrospectivos
Rinite/terapia
Sinusite/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); G07GZ97H65 (Clotrimazole)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.2460/javma.250.3.309



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