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[PMID]:28410675
[Au] Autor:Wrzosek M; Ives JR; Karczewski M; Dziadkowiak E; Gruszka E
[Ad] Endereço:Department of Internal Medicine and Clinic for Horses, Dogs and Cats, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki 47, 50-366 Wroclaw, Poland. Electronic address: marcin.wrzosek@up.wroc.pl.
[Ti] Título:The relationship between epileptiform discharges and background activity in the visual analysis of electroencephalographic examinations in dogs with seizures of different etiologies.
[So] Source:Vet J;222:41-51, 2017 Apr.
[Is] ISSN:1532-2971
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described and compared. The dogs included neurologically healthy controls (N, n = 19), dogs with portosystemic shunt (PSS, n = 9), dogs with intracranial pathologies (IP, n = 27) and dogs with idiopathic epilepsy (IE, n = 70). A visual EEG analysis revealed significantly more pronounced high voltage, low-frequency BGA in the PSS and IP groups in comparison to the N and IE groups (PSS vs. N, PSS vs. IE P <0.0001; IP vs. N, IP vs. IE P = 0.043). At least one ED in the recording was found in 47.37% (n = 9/19) of the individuals in the N group, 88.9% (n = 8/9) of the dogs in the PSS group, 77.78% (n = 21/27) of the dogs in the IP group and 61.43% (n = 43/70) of the dogs in the IE group. The presence of bilateral symmetric triphasic (BST) waves was significantly higher in the PSS group than in the remaining groups. There was a strong prevalence of spike-waves in dogs with idiopathic epilepsy and of BST waves in dogs with portosystemic shunt. None of the dogs in group N had spike-waves or BST activity. EDs were observed more frequently in high and very high voltage, low frequency BGA than in low voltage, high frequency BGA.
[Mh] Termos MeSH primário: Eletroencefalografia/veterinária
Epilepsia/veterinária
[Mh] Termos MeSH secundário: Anestesia/veterinária
Animais
Cães
Epilepsia/etiologia
Feminino
Masculino
Medetomidina
Estimulação Luminosa
Exame Físico/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170416
[St] Status:MEDLINE


  2 / 1119 MEDLINE  
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[PMID]:28406906
[Au] Autor:Abe Y; Tsurugizawa T; Le Bihan D
[Ad] Endereço:NeuroSpin, Joliot Institute, Commissariat à l'énergie atomique et aux énergies alternatives, Gif-sur-Yvette, France.
[Ti] Título:Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia.
[So] Source:PLoS Biol;15(4):e2001494, 2017 Apr.
[Is] ISSN:1545-7885
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Diffusion functional MRI (DfMRI) reveals neuronal activation even when neurovascular coupling is abolished, contrary to blood oxygenation level-dependent (BOLD) functional MRI (fMRI). Here, we show that the water apparent diffusion coefficient (ADC) derived from DfMRI increased in specific rat brain regions under anesthetic conditions, reflecting the decreased neuronal activity observed with local field potentials (LFPs), especially in regions involved in wakefulness. In contrast, BOLD signals showed nonspecific changes, reflecting systemic effects of the anesthesia on overall brain hemodynamics status. Electrical stimulation of the central medial thalamus nucleus (CM) exhibiting this anesthesia-induced ADC increase led the animals to transiently wake up. Infusion in the CM of furosemide, a specific neuronal swelling blocker, led the ADC to increase further locally, although LFP activity remained unchanged, and increased the current threshold awakening the animals under CM electrical stimulation. Oppositely, induction of cell swelling in the CM through infusion of a hypotonic solution (-80 milliosmole [mOsm] artificial cerebrospinal fluid [aCSF]) led to a local ADC decrease and a lower current threshold to wake up the animals. Strikingly, the local ADC changes produced by blocking or enhancing cell swelling in the CM were also mirrored remotely in areas functionally connected to the CM, such as the cingulate and somatosensory cortex. Together, those results strongly suggest that neuronal swelling is a significant mechanism underlying DfMRI.
[Mh] Termos MeSH primário: Anestesia Geral
Encéfalo/efeitos dos fármacos
Isoflurano
Medetomidina
[Mh] Termos MeSH secundário: Potenciais de Ação
Animais
Encéfalo/metabolismo
Mapeamento Encefálico
Circulação Cerebrovascular
Difusão
Imagem de Difusão por Ressonância Magnética
Relação Dose-Resposta a Droga
Estimulação Elétrica
Masculino
Oxigênio/sangue
Ratos Wistar
Vigília
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine); S88TT14065 (Oxygen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pbio.2001494


  3 / 1119 MEDLINE  
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[PMID]:28363076
[Au] Autor:Gerlach CA; Kummrow MS; Meyer LC; Zeiler GE; Stegmann GF; Buck RK; Fosgate GT; Kästner SB
[Ti] Título:CONTINUOUS INTRAVENOUS INFUSION ANESTHESIA WITH MEDETOMIDINE, KETAMINE, AND MIDAZOLAM AFTER INDUCTION WITH A COMBINATION OF ETORPHINE, MEDETOMIDINE, AND MIDAZOLAM OR WITH MEDETOMIDINE, KETAMINE, AND BUTORPHANOL IN IMPALA (AEPYCEROS MELAMPUS).
[So] Source:J Zoo Wildl Med;48(1):62-71, 2017 Mar.
[Is] ISSN:1042-7260
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In order to develop a long-term anesthesia for flighty antelope species in field situations, two different protocols for induction and maintenance with an intravenous infusion were evaluated in wild-caught impala ( Aepyceros melampus ). Ten adult female impala were induced with two induction protocols: one consisted of 0.2 mg/kg medetomidine, 4 mg/kg ketamine, and 0.15 mg/kg butorphanol (MKB) and one consisted of 0.375 mg/kg etorphine, 0.2 mg/kg medetomidine, and 0.2 mg/kg midazolam (EMM). In both treatments, anesthesia was maintained with a continuous intravenous infusion (CII) at an initial dose rate of 1.2 µg/kg per hr medetomidine, 2.4 mg/kg per hr ketaminen and 36 µg/kg per hr midazolam. Partial reversal was achieved with naltrexone (2 : 1 mg butorphanol; 20 : 1 mg etorphine) and atipamezole (5 : 1 mg medetomidine). Evaluation of anesthesia included respiratory rate, heart rate, rectal temperature, arterial blood pressure, oxygen saturation, end tidal carbon dioxide tension, and tidal volume at 5-min intervals, palpebral reflex and response to painful stimuli at 15-min intervals, and arterial blood gases at 30-min intervals. Plasma cortisol concentration was determined after induction and before reversal. Duration and quality of induction and recovery were evaluated. EMM caused a faster induction of 9.5 ± 2.9 min compared to 11.0 ± 6.4 min in MKB. Recovery was also quicker in EMM (EMM: 6.3 ± 5.4 min; MKB: 9.8 ± 6.0 min). However, EMM also produced more cardiopulmonary side effects, including hypoxemia and hypercapnia, and calculated oxygenation indices (PaCO -PETCO ) were worse than in MKB. One animal died after induction with EMM. The CII provided surgical anesthesia in 7 of 10 animals in MKB and in 9 of 9 animals in EMM for 120 min. In conclusion, the MKB induction protocol had advantages for prolonged anesthesia in impala with significantly less cardiopulmonary depression compared to EMM. The comparably decreased anesthetic depth could easily be adjusted by an increase of the CII.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anestésicos Intravenosos/farmacologia
Antílopes
Hipnóticos e Sedativos/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Período de Recuperação da Anestesia
Anestésicos Intravenosos/administração & dosagem
Animais
Butorfanol/administração & dosagem
Butorfanol/farmacologia
Esquema de Medicação
Quimioterapia Combinada
Etorfina/administração & dosagem
Etorfina/farmacologia
Feminino
Hipnóticos e Sedativos/administração & dosagem
Ketamina/administração & dosagem
Ketamina/farmacologia
Medetomidina/administração & dosagem
Medetomidina/farmacologia
Midazolam/administração & dosagem
Midazolam/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anesthetics, Intravenous); 0 (Hypnotics and Sedatives); 42M2Y6NU9O (Etorphine); 690G0D6V8H (Ketamine); MR15E85MQM (Medetomidine); QV897JC36D (Butorphanol); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1638/2016-0010.1


  4 / 1119 MEDLINE  
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[PMID]:28328950
[Au] Autor:Schmitz S; Tacke S; Guth B; Henke J
[Ad] Endereço:Department of Nonclinical Drug Safety, Biological Laboratory Service, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
[Ti] Título:Repeated anaesthesia with isoflurane and medetomidine-midazolam-fentanyl in guinea pigs and its influence on physiological parameters.
[So] Source:PLoS One;12(3):e0174423, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Repeated anaesthesia may be required in experimental protocols and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs). This study investigated the effects of repeated anaesthesia with either medetomidine-midazolam-fentanyl (MMF) or isoflurane (Iso) on physiological parameters in the GP. Twelve GPs were repeatedly administered with MMF or Iso in two anaesthesia sets. One set consisted of six 40-min anaesthesias, performed over 3 weeks (2 per week); the anaesthetic used first was randomized. Prior to Iso anaesthesia, atropine was injected. MMF anaesthesia was antagonized with AFN (atipamezole-flumazenil-naloxone). Abdominally implanted radio-telemetry devices recorded the mean arterial blood pressure (MAP), heart rate (HR) and core body temperature continuously. Additionally, respiratory rate, blood glucose and body weight were assessed. An operable state could be achieved and maintained for 40 min in all GPs. During the surgical tolerance with MMF, the GPs showed a large MAP range between the individuals. In the MMF wake- up phase, the time was shortened until the righting reflex (RR) returned and that occurred at lower MAP and HR values. Repeated Iso anaesthesia led to an increasing HR during induction (anaesthesias 2-6), non-surgical tolerance (anaesthesias 3-6) and surgical tolerance (anaesthesias 4, 6). Both anaesthetics may be used repeatedly, as repeating the anaesthesias resulted in only slightly different physiological parameters, compared to those seen with single anaesthesias. The regular atropine premedication induced HR increases and repeated MMF anaesthesia resulted in a metabolism increase which led to the faster return of RR. Nevertheless, Iso's anaesthesia effects of strong respiratory depression and severe hypotension remained. Based on this increased anaesthesia risk with Iso, MMF anaesthesia is preferable for repeated use in GPs.
[Mh] Termos MeSH primário: Fentanila/administração & dosagem
Isoflurano/administração & dosagem
Medetomidina/administração & dosagem
Midazolam/administração & dosagem
Fenômenos Fisiológicos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anestesia/métodos
Anestésicos Combinados/administração & dosagem
Animais
Glicemia/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Cobaias
Frequência Cardíaca/efeitos dos fármacos
Masculino
Taxa Respiratória/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Blood Glucose); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine); R60L0SM5BC (Midazolam); UF599785JZ (Fentanyl)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0174423


  5 / 1119 MEDLINE  
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[PMID]:28281769
[Au] Autor:Stegmann GF; Williams CJ; Franklin C; Wang T; Axelsson M
[Ad] Endereço:Department of Companion Animal Clinical Studies, University of Pretoria. frik.stegmann@up.ac.za.
[Ti] Título:Long-term surgical anaesthesia with isoflurane in human habituated Nile Crocodiles.
[So] Source:J S Afr Vet Assoc;88(0):e1-e6, 2017 Feb 24.
[Is] ISSN:2224-9435
[Cp] País de publicação:South Africa
[La] Idioma:eng
[Ab] Resumo:A suitable long-term anaesthetic technique was required for implantation of physiological sensors and telemetric devices in sub-adult Nile crocodiles (Crocodylus niloticus) to allow the collection of physiological data. Five Nile crocodiles with a median body mass of 24 kg were used. After manual capture, they were blindfolded and 0.2 mL (1 mg/mL) medetomidine was administered intramuscularly in four of the animals which had an estimated body mass between 20 kg and 30 kg. One crocodile with an estimated body mass of 50 kg received 0.5 mL. For induction, 5 mL propofol (10 mg/mL) was injected intravenously into the occipital sinus. Additional doses were given when required to ensure adequate anaesthesia. Anaesthesia was maintained with 1.5% isoflurane. Ventilation was controlled. Local anaesthesia was administered for surgical incision and external placement of the radio transmitter. Medetomidine was antagonised with atipamezole at the end of surgery. Median heart rate during surgery was 22 beats/min, at extubation 32 beats per min and 30 beats per min the following day at the same body temperature as under anaesthesia. Median body temperature of the animals increased from 27.3 °C to 27.9 °C during anaesthesia, as room temperature increased from 24.5 °C to 29.0 °C during surgery. Anaesthesia was successfully induced with intramuscular medetomidine and intravenous propofol and was maintained with isoflurane for the placement of telemetric implants. Intraoperative analgesia was supplemented with lidocaine infiltration. Perioperative physiological parameters remained stable and within acceptable clinical limits. Multiple factors appear to influence these variables during the recovery period, including residual anaesthetic effects, environmental temperature and physical activity.
[Mh] Termos MeSH primário: Jacarés e Crocodilos/fisiologia
Jacarés e Crocodilos/cirurgia
Anestésicos Inalatórios/farmacologia
Isoflurano/farmacologia
[Mh] Termos MeSH secundário: Anestésicos Inalatórios/administração & dosagem
Criação de Animais Domésticos
Animais
Frequência Cardíaca
Seres Humanos
Hipnóticos e Sedativos/administração & dosagem
Isoflurano/administração & dosagem
Medetomidina/administração & dosagem
Monitorização Fisiológica/veterinária
África do Sul
Telemetria/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Hypnotics and Sedatives); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.4102/jsava.v88i0.1451


  6 / 1119 MEDLINE  
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[PMID]:28217085
[Au] Autor:Bukhari Q; Schroeter A; Cole DM; Rudin M
[Ad] Endereço:Institute of Biomedical Engineering, University of Zurich and ETH Zurich Zurich, Switzerland.
[Ti] Título:Resting State fMRI in Mice Reveals Anesthesia Specific Signatures of Brain Functional Networks and Their Interactions.
[So] Source:Front Neural Circuits;11:5, 2017.
[Is] ISSN:1662-5110
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:fMRI studies in mice typically require the use of anesthetics. Yet, it is known that anesthesia alters responses to stimuli or functional networks at rest. In this work, we have used Dual Regression analysis Network Modeling to investigate the effects of two commonly used anesthetics, isoflurane and medetomidine, on rs-fMRI derived functional networks, and in particular to what extent anesthesia affected the interaction within and between these networks. Experimental data have been used from a previous study (Grandjean et al., 2014). We applied multivariate ICA analysis and Dual Regression to infer the differences in functional connectivity between isoflurane- and medetomidine-anesthetized mice. Further network analysis was performed to investigate within- and between-network connectivity differences between these anesthetic regimens. The results revealed five major networks in the mouse brain: lateral cortical, associative cortical, default mode, subcortical, and thalamic network. The anesthesia regime had a profound effect both on within- and between-network interactions. Under isoflurane anesthesia predominantly intra- and inter-cortical interactions have been observed, with only minor interactions involving subcortical structures and in particular attenuated cortico-thalamic connectivity. In contrast, medetomidine-anesthetized mice displayed subcortical functional connectivity including interactions between cortical and thalamic ICA components. Combining the two anesthetics at low dose resulted in network interaction that constituted the superposition of the interaction observed for each anesthetic alone. The study demonstrated that network modeling is a promising tool for analyzing the brain functional architecture in mice and comparing alterations therein caused by different physiological or pathological states. Understanding the differential effects of anesthetics on brain networks and their interaction is essential when interpreting fMRI data recorded under specific physiological and pathological conditions.
[Mh] Termos MeSH primário: Anestésicos/farmacologia
Mapeamento Encefálico/métodos
Encéfalo/efeitos dos fármacos
Encéfalo/diagnóstico por imagem
Isoflurano/farmacologia
Imagem por Ressonância Magnética/métodos
Medetomidina/farmacologia
Rede Nervosa/efeitos dos fármacos
Rede Nervosa/diagnóstico por imagem
[Mh] Termos MeSH secundário: Anestésicos/administração & dosagem
Animais
Interações Medicamentosas
Isoflurano/administração & dosagem
Camundongos
Modelos Neurológicos
Descanso
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.3389/fncir.2017.00005


  7 / 1119 MEDLINE  
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[PMID]:28215681
[Au] Autor:Kheirkhah MS; Mollapour Sisakht M; Mohammadsadegh M; Moslemi HR
[Ad] Endereço:Department of Reproductive Technologies, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran. Electronic address: kheirkhahsaeed@yahoo.com.
[Ti] Título:Sperm evaluation of Jungle Cat (Felis chaus) obtained by urethral catheterization (CT) after medetomidine administration.
[So] Source:Theriogenology;91:17-20, 2017 Mar 15.
[Is] ISSN:1879-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate semen from Jungle Cat (Felis chaus) by urethral catheterization (CT) after medetomidine administration that offers feasible and different approaches to obtaining good quality sperm, especially in wild felids. Accordingly, this method was tested in five Jungle Cats. After general anesthesia with the α2-agonist medetomidine (which also stimulates semen release into the urethra) and ketamine, an abdomen ultrasound was performed to locate dilation of the first segment of the urethra (prostatic urethra). A commercial Tom cat urinary catheter 3-5 (depending on the size of the animal) was advanced into the urethra to reach the semen full dilated primary region of the urethra, so as to allow semen collection into the lumen of the catheter by capillary forces. After retraction, sperm volumes between 69 ± 27.92 yielded motility of 77.13 ± 14.15 (mean ± SD) with a mean sperm concentration of 75.13 ± 17.05 million/ml. The results of this study showed that semen collection in jungle cat is feasible, using this method. This study describes a simple, useful in field, inexpensive method which does not require the training of the animal and is better than other methods. Samples have normal pH, suitable color and consolidation, high concentration and lower contamination with excellent motility in Jungle Cat and potentially, other wild felid species, as an alternative to electro-ejaculation.
[Mh] Termos MeSH primário: Agonistas de Receptores Adrenérgicos alfa 2/farmacologia
Felis/fisiologia
Medetomidina/farmacologia
Análise do Sêmen/veterinária
Recuperação Espermática/veterinária
[Mh] Termos MeSH secundário: Animais
Masculino
Sêmen/efeitos dos fármacos
Motilidade Espermática
Cateterismo Urinário/métodos
Cateterismo Urinário/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic alpha-2 Receptor Agonists); MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


  8 / 1119 MEDLINE  
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[PMID]:28118413
[Au] Autor:Fandos Esteruelas N; Cattet M; Zedrosser A; Stenhouse GB; Küker S; Evans AL; Arnemo JM
[Ad] Endereço:Department of Forestry and Wildlife Management, Inland Norway University of Applied Sciences, Campus Evenstad, Elverum, Norway.
[Ti] Título:A Double-Blinded, Randomized Comparison of Medetomidine-Tiletamine-Zolazepam and Dexmedetomidine-Tiletamine-Zolazepam Anesthesia in Free-Ranging Brown Bears (Ursus Arctos).
[So] Source:PLoS One;12(1):e0170764, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared anesthetic features, blood parameters, and physiological responses to either medetomidine-tiletamine-zolazepam or dexmedetomidine-tiletamine-zolazepam using a double-blinded, randomized experimental design during 40 anesthetic events of free-ranging brown bears (Ursus arctos) either captured by helicopter in Sweden or by culvert trap in Canada. Induction was smooth and predictable with both anesthetic protocols. Induction time, the need for supplemental drugs to sustain anesthesia, and capture-related stress were analyzed using generalized linear models, but anesthetic protocol did not differentially affect these variables. Arterial blood gases and acid-base status, and physiological responses were examined using linear mixed models. We documented acidemia (pH of arterial blood < 7.35), hypoxemia (partial pressure of arterial oxygen < 80 mmHg), and hypercapnia (partial pressure of arterial carbon dioxide ≥ 45 mmHg) with both protocols. Arterial pH and oxygen partial pressure were similar between groups with the latter improving markedly after oxygen supplementation (p < 0.001). We documented dose-dependent effects of both anesthetic protocols on induction time and arterial oxygen partial pressure. The partial pressure of arterial carbon dioxide increased as respiratory rate increased with medetomidine-tiletamine-zolazepam, but not with dexmedetomidine-tiletamine-zolazepam, demonstrating a differential drug effect. Differences in heart rate, respiratory rate, and rectal temperature among bears could not be attributed to the anesthetic protocol. Heart rate increased with increasing rectal temperature (p < 0.001) and ordinal day of capture (p = 0.002). Respiratory rate was significantly higher in bears captured by helicopter in Sweden than in bears captured by culvert trap in Canada (p < 0.001). Rectal temperature significantly decreased over time (p ≤ 0.05). Overall, we did not find any benefit of using dexmedetomidine-tiletamine-zolazepam instead of medetomidine-tiletamine-zolazepam in the anesthesia of brown bears. Both drug combinations appeared to be safe and reliable for the anesthesia of free-ranging brown bears captured by helicopter or by culvert trap.
[Mh] Termos MeSH primário: Anestesia/veterinária
Anestésicos
Dexmedetomidina
Medetomidina
Tiletamina
Ursidae/fisiologia
Zolazepam
[Mh] Termos MeSH secundário: Alberta
Anestésicos/farmacologia
Animais
Animais Selvagens
Temperatura Corporal/efeitos dos fármacos
Dióxido de Carbono/sangue
Conjuntos de Dados como Assunto
Dexmedetomidina/farmacologia
Método Duplo-Cego
Combinação de Medicamentos
Hemodinâmica/efeitos dos fármacos
Masculino
Medetomidina/farmacologia
Oxigênio/sangue
Oxigenoterapia
Pressão Parcial
Respiração/efeitos dos fármacos
Estresse Fisiológico/efeitos dos fármacos
Estresse Fisiológico/fisiologia
Estresse Psicológico/fisiopatologia
Suécia
Tiletamina/farmacologia
Zolazepam/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics); 0 (Drug Combinations); 0 (tiletamine, zolazepam drug combination); 142M471B3J (Carbon Dioxide); 2YFC543249 (Tiletamine); 67VB76HONO (Dexmedetomidine); G1R474U58U (Zolazepam); MR15E85MQM (Medetomidine); S88TT14065 (Oxygen)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0170764


  9 / 1119 MEDLINE  
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[PMID]:28058981
[Au] Autor:Tsurugizawa T; Abe Y; Le Bihan D
[Ad] Endereço:NeuroSpin, Commissariat à l'Energie Atomique et aux Energies Alternatives, CEA Saclay, Gif-sur-Yvette, France.
[Ti] Título:Water apparent diffusion coefficient correlates with gamma oscillation of local field potentials in the rat brain nucleus accumbens following alcohol injection.
[So] Source:J Cereb Blood Flow Metab;37(9):3193-3202, 2017 Sep.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ethanol is a vasoactive agent as well as psychoactive drug. The neurovascular response, coupled with neuronal activity, can be disturbed by alcohol intake. Hence, blood oxygenation level-dependent (BOLD) fMRI, which relies on neurovascular coupling, might not be reliable to reflect alcohol-induced neuronal responses. Recently, diffusion fMRI has been shown to be more sensitive to neural activity than BOLD fMRI even when neurovascular coupling is disrupted. Especially, the apparent diffusion coefficient (ADC) is sensitive to changes occurring in the cellular tissue structure upon activation. In the present study, we compared BOLD fMRI signals, ADC, and local field potentials (LFPs) in the nucleus accumbens (NAc) following injection of an ethanol solution (0.4 g/kg body weight) in rats under medetomidine anesthesia. An increase in the gamma oscillation power of LFP and an ADC decrease were observed 5 min after the injection of EtOH. The BOLD signals showed a negative slow drift, similar to mean arterial pressure with a peak approximately 10 min after the injection. These results confirm that DfMRI can be a better marker of the neuronal activity than BOLD fMRI, especially when the brain hemodynamic status is changed by vasoactive drugs such as ethanol.
[Mh] Termos MeSH primário: Potenciais de Ação/efeitos dos fármacos
Mapeamento Encefálico/métodos
Imagem de Difusão por Ressonância Magnética/métodos
Etanol/farmacologia
Ritmo Gama
Núcleo Accumbens/diagnóstico por imagem
[Mh] Termos MeSH secundário: Anestesia Geral
Animais
Isoflurano
Masculino
Medetomidina
Neurônios/fisiologia
Acoplamento Neurovascular/efeitos dos fármacos
Núcleo Accumbens/efeitos dos fármacos
Oxigênio/sangue
Ratos Wistar
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
059QF0KO0R (Water); 3K9958V90M (Ethanol); CYS9AKD70P (Isoflurane); MR15E85MQM (Medetomidine); S88TT14065 (Oxygen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.1177/0271678X16685104


  10 / 1119 MEDLINE  
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[PMID]:27725350
[Au] Autor:Jeong DH; Yang JJ; Seok SH; Song DJ; Yeon SC
[Ad] Endereço:Species Restoration Technology Institute of Korea National Park Service, Gurye 542-853, Republic of Korea.
[Ti] Título:Cardiorespiratory effects of isoflurane in Asiatic black bears (Ursus thibetanus) anesthetized with intramuscular medetomidine and zolazepam/tiletamine.
[So] Source:J Vet Med Sci;79(1):153-159, 2017 Jan 20.
[Is] ISSN:1347-7439
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The objective of this study was to determine the dose-dependent effects of isoflurane on various cardiovascular parameters and the stable range of isoflurane concentrations in Asiatic black bears (Ursus thibetanus). Seven Asiatic black bears were intramuscularly injected with medetomidine, zolazepam and tiletamine (MZT) to induce anesthesia, and anesthesia was maintained by administering isoflurane in 100% oxygen (4 l/min) without mechanical ventilation. Several cardiovascular parameters were measured at five end-tidal isoflurane concentrations (0.5, 1.0, 1.5, 2.0, and 2.5%). Blood was collected from the femoral artery before administration of isoflurane and after each administration for immediate blood gas analysis. Isoflurane produced dose-dependent increases in heart rate, respiratory rate, minute volume, end-tidal carbon dioxide (CO ) partial pressure and the partial pressure of arterial CO , and dose-dependent decreases in non-invasive blood pressure and tidal volume. Rectal temperature, oxygenation and acid-base balance were unaffected by isoflurane. All parameters in this study were in a clinically acceptable range at all times. The data show that the combination of MZT and isoflurane is suitable for general anesthesia in Asiatic black bears with spontaneous breathing during prolonged procedures. End-tidal isoflurane concentrations of 0.5 to 2.5% can be used in Asiatic black bears without adverse side effects.
[Mh] Termos MeSH primário: Anestesia Geral/veterinária
Anestésicos Combinados
Frequência Cardíaca
Isoflurano
Medetomidina
Respiração
Tiletamina
Ursidae
Zolazepam
[Mh] Termos MeSH secundário: Animais
Temperatura Corporal
Combinação de Medicamentos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Combined); 0 (Drug Combinations); 0 (tiletamine, zolazepam drug combination); 2YFC543249 (Tiletamine); CYS9AKD70P (Isoflurane); G1R474U58U (Zolazepam); MR15E85MQM (Medetomidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161012
[St] Status:MEDLINE
[do] DOI:10.1292/jvms.16-0290



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