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[PMID]:29370235
[Au] Autor:Li X; Wu GY; Yao J; Yang Y; Ye JN; Sui JF
[Ad] Endereço:Department of Physiology, College of Basic Medical Science, Third Military Medical University, Chongqing, P.R. China.
[Ti] Título:Time-limited involvement of caudal anterior cingulate cortex in trace eyeblink conditioning retrieval is dependent on conditioned stimulus intensity.
[So] Source:PLoS One;13(1):e0191320, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The medial prefrontal cortex (mPFC) has been widely investigated for its roles in learning and memory. The present study investigated the time-limited involvement of the caudal anterior cingulate cortex (cACC) of the mPFC in the retrieval process for a simple associative motor learning, trace eyeblink conditioning (tEBC), using a 75 dB or 100 dB tone as the conditioned stimulus (CS). The GABAA receptor agonist muscimol was injected into the cACC of guinea pigs at 1 day or 4 weeks after tEBC acquisition. When muscimol was administered 1 day after tEBC acquisition, the conditioned response (CR) of the 75 dB group was severely impaired, whereas the CR of the 100 dB group exhibited no significant change relative to the control. When muscimol was administered 4 weeks after tEBC acquisition, the CR was impaired in both the 75 dB and 100 dB groups. This study indicate that the cACC of the mPFC is necessary for recent retrieval of tEBC with a low-intensity CS but not of tEBC with a high-intensity CS, whereas for remote retrieval of tEBC, the cACC of the mPFC is essential regardless of whether the CS intensity is high or low. These results support a conditional role for the mPFC in modulating recent retrieval of tEBC and a persistent role for its involvement in remote retrieval of tEBC.
[Mh] Termos MeSH primário: Condicionamento Palpebral
Córtex Pré-Frontal/fisiologia
[Mh] Termos MeSH secundário: Animais
Agonistas de Receptores de GABA-A/farmacologia
Cobaias
Masculino
Muscimol/farmacologia
Córtex Pré-Frontal/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191320


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[PMID]:29240774
[Au] Autor:DeWind NK; Peng J; Luo A; Brannon EM; Platt ML
[Ad] Endereço:Psychology Department, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
[Ti] Título:Pharmacological inactivation does not support a unique causal role for intraparietal sulcus in the discrimination of visual number.
[So] Source:PLoS One;12(12):e0188820, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The "number sense" describes the intuitive ability to quantify without counting. Single neuron recordings in non-human primates and functional imaging in humans suggest the intraparietal sulcus is an important neuroanatomical locus of numerical estimation. Other lines of inquiry implicate the IPS in numerous other functions, including attention and decision making. Here we provide a direct test of whether IPS has functional specificity for numerosity judgments. We used muscimol to reversibly and independently inactivate the ventral and lateral intraparietal areas in two monkeys performing a numerical discrimination task and a color discrimination task, roughly equilibrated for difficulty. Inactivation of either area caused parallel impairments in both tasks and no evidence of a selective deficit in numerical processing. These findings do not support a causal role for the IPS in numerical discrimination, except insofar as it also has a role in the discrimination of color. We discuss our findings in light of several alternative hypotheses of IPS function, including a role in orienting responses, a general cognitive role in attention and decision making processes and a more specific role in ordinal comparison that encompasses both number and color judgments.
[Mh] Termos MeSH primário: Lobo Parietal/fisiologia
Visão Ocular
[Mh] Termos MeSH secundário: Animais
Comportamento Animal
Agonistas de Receptores de GABA-A/administração & dosagem
Haplorrinos
Seres Humanos
Masculino
Muscimol/administração & dosagem
Estimulação Luminosa
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188820


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[PMID]:29184207
[Au] Autor:Jaepel J; Hübener M; Bonhoeffer T; Rose T
[Ad] Endereço:Synapses - Circuits - Plasticity, Max Planck Institute of Neurobiology, Martinsried, Germany.
[Ti] Título:Lateral geniculate neurons projecting to primary visual cortex show ocular dominance plasticity in adult mice.
[So] Source:Nat Neurosci;20(12):1708-1714, 2017 Dec.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Experience-dependent plasticity in the mature visual system is widely considered to be cortical. Using chronic two-photon Ca imaging of thalamic afferents in layer 1 of binocular visual cortex, we provide evidence against this tenet: the respective dorsal lateral geniculate nucleus (dLGN) cells showed pronounced ocular dominance (OD) shifts after monocular deprivation in adult mice. Most (86%), but not all, of dLGN cell boutons were monocular during normal visual experience. Following deprivation, initially deprived-eye-dominated boutons reduced or lost their visual responsiveness to that eye and frequently became responsive to the non-deprived eye. This cannot be explained by eye-specific cortical changes propagating to dLGN via cortico-thalamic feedback because the shift in dLGN responses was largely resistant to cortical inactivation using the GABA receptor agonist muscimol. Our data suggest that OD shifts observed in the binocular visual cortex of adult mice may at least partially reflect plasticity of eye-specific inputs onto dLGN neurons.
[Mh] Termos MeSH primário: Dominância Ocular/fisiologia
Corpos Geniculados/citologia
Corpos Geniculados/fisiologia
Plasticidade Neuronal/fisiologia
Neurônios/fisiologia
Córtex Visual/citologia
Córtex Visual/fisiologia
[Mh] Termos MeSH secundário: Animais
Cegueira/patologia
Retroalimentação Sensorial/fisiologia
Agonistas GABAérgicos/farmacologia
Corpos Geniculados/efeitos dos fármacos
Masculino
Camundongos
Muscimol/farmacologia
Plasticidade Neuronal/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Neurônios Aferentes/fisiologia
Tálamo/citologia
Tálamo/fisiologia
Visão Binocular/fisiologia
Vias Visuais/citologia
Vias Visuais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171212
[Lr] Data última revisão:
171212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171130
[St] Status:MEDLINE
[do] DOI:10.1038/s41593-017-0021-0


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[PMID]:28821646
[Au] Autor:Minert A; Yatziv SL; Devor M
[Ad] Endereço:Department of Cell and Developmental Biology, Institute of Life Sciences, and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
[Ti] Título:Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.
[So] Source:J Neurosci;37(38):9320-9331, 2017 Sep 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The transition from wakefulness to general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and antinociception). An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spinal cord mediated by dedicated axonal pathways. Previously, we documented induction of an anesthesia-like state in rats by microinjection of small amounts of GABA -receptor agonists into an upper brainstem region named the mesopontine tegmental anesthesia area (MPTA). Correspondingly, lesioning this area rendered animals resistant to systemically delivered anesthetics. Here, using rats of both sexes, we applied a modified microinjection method that permitted localization of the anesthetic-sensitive neurons with much improved spatial resolution. Microinjected at the MPTA hotspot identified, exposure of 1900 or fewer neurons to muscimol was sufficient to sustain whole-body general anesthesia; microinjection as little as 0.5 mm off-target did not. The GABAergic anesthetics pentobarbital and propofol were also effective. The GABA-sensitive cell cluster is centered on a tegmental (reticular) field traversed by fibers of the superior cerebellar peduncle. It has no specific nuclear designation and has not previously been implicated in brain-state transitions. General anesthesia permits pain-free surgery. Furthermore, because anesthetic agents have the unique ability to reversibly switch the brain from wakefulness to a state of unconsciousness, knowing how and where they work is a potential route to unraveling the neural mechanisms that underlie awareness itself. Using a novel method, we have located a small, and apparently one of a kind, cluster of neurons in the mesopontine tegmentum that are capable of effecting brain-state switching when exposed to GABA -receptor agonists. This action appears to be mediated by a network of dedicated axonal pathways that project directly and/or indirectly to nearby arousal nuclei of the brainstem and to more distant targets in the forebrain and spinal cord.
[Mh] Termos MeSH primário: Anestésicos Gerais/administração & dosagem
Mesencéfalo/efeitos dos fármacos
Ponte/efeitos dos fármacos
Ponte/fisiologia
Inconsciência/induzido quimicamente
Inconsciência/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Muscimol/administração & dosagem
Neurônios/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, General); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0544-17.2017


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[PMID]:28758995
[Au] Autor:Miller KJ; Botvinick MM; Brody CD
[Ad] Endereço:Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA.
[Ti] Título:Dorsal hippocampus contributes to model-based planning.
[So] Source:Nat Neurosci;20(9):1269-1276, 2017 Sep.
[Is] ISSN:1546-1726
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Planning can be defined as action selection that leverages an internal model of the outcomes likely to follow each possible action. Its neural mechanisms remain poorly understood. Here we adapt recent advances from human research for rats, presenting for the first time an animal task that produces many trials of planned behavior per session, making multitrial rodent experimental tools available to study planning. We use part of this toolkit to address a perennially controversial issue in planning: the role of the dorsal hippocampus. Although prospective hippocampal representations have been proposed to support planning, intact planning in animals with damaged hippocampi has been repeatedly observed. Combining formal algorithmic behavioral analysis with muscimol inactivation, we provide causal evidence directly linking dorsal hippocampus with planning behavior. Our results and methods open the door to new and more detailed investigations of the neural mechanisms of planning in the hippocampus and throughout the brain.
[Mh] Termos MeSH primário: Comportamento Animal/fisiologia
Comportamento Exploratório/fisiologia
Hipocampo/fisiologia
Recognição (Psicologia)/fisiologia
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Comportamento Exploratório/efeitos dos fármacos
Agonistas de Receptores de GABA-A/toxicidade
Hipocampo/efeitos dos fármacos
Hipocampo/patologia
Masculino
Muscimol/toxicidade
Estimulação Luminosa/métodos
Ratos
Ratos Long-Evans
Recognição (Psicologia)/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1038/nn.4613


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[PMID]:28648500
[Au] Autor:Banerjee SB; Gutzeit VA; Baman J; Aoued HS; Doshi NK; Liu RC; Ressler KJ
[Ad] Endereço:Behavioral Neuroscience and Psychiatric Disorders, Emory University, Atlanta, GA 30329, USA; Department of Biology, Emory University, Atlanta, GA 30322, USA.
[Ti] Título:Perineuronal Nets in the Adult Sensory Cortex Are Necessary for Fear Learning.
[So] Source:Neuron;95(1):169-179.e3, 2017 Jul 05.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lattice-like structures known as perineuronal nets (PNNs) are key components of the extracellular matrix (ECM). Once fully crystallized by adulthood, they are largely stable throughout life. Contrary to previous reports that PNNs inhibit processes involving plasticity, here we report that the dynamic regulation of PNN expression in the adult auditory cortex is vital for fear learning and consolidation in response to pure tones. Specifically, after first confirming the necessity of auditory cortical activity for fear learning and consolidation, we observed that mRNA levels of key proteoglycan components of PNNs were enhanced 4 hr after fear conditioning but were no longer different from the control groups 24 hr later. A similar pattern of regulation was observed in numbers of cells surrounded by PNNs and area occupied by them in the auditory cortex. Finally, the removal of auditory cortex PNNs resulted in a deficit in fear learning and consolidation.
[Mh] Termos MeSH primário: Córtex Auditivo/metabolismo
Condicionamento (Psicologia)/fisiologia
Matriz Extracelular/metabolismo
Medo/fisiologia
Aprendizagem/fisiologia
Proteoglicanas/genética
[Mh] Termos MeSH secundário: Animais
Córtex Auditivo/efeitos dos fármacos
Córtex Auditivo/fisiologia
Condicionamento (Psicologia)/efeitos dos fármacos
Matriz Extracelular/fisiologia
Medo/efeitos dos fármacos
Agonistas de Receptores de GABA-A/farmacologia
Aprendizagem/efeitos dos fármacos
Consolidação da Memória/efeitos dos fármacos
Consolidação da Memória/fisiologia
Camundongos
Muscimol/farmacologia
Proteoglicanas/metabolismo
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 0 (Proteoglycans); 0 (RNA, Messenger); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


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[PMID]:28343868
[Au] Autor:Guise KG; Shapiro ML
[Ad] Endereço:Department of Neuroscience, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, USA.
[Ti] Título:Medial Prefrontal Cortex Reduces Memory Interference by Modifying Hippocampal Encoding.
[So] Source:Neuron;94(1):183-192.e8, 2017 Apr 05.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The prefrontal cortex (PFC) is crucial for accurate memory performance when prior knowledge interferes with new learning, but the mechanisms that minimize proactive interference are unknown. To investigate these, we assessed the influence of medial PFC (mPFC) activity on spatial learning and hippocampal coding in a plus maze task that requires both structures. mPFC inactivation did not impair spatial learning or retrieval per se, but impaired the ability to follow changing spatial rules. mPFC and CA1 ensembles recorded simultaneously predicted goal choices and tracked changing rules; inactivating mPFC attenuated CA1 prospective coding. mPFC activity modified CA1 codes during learning, which in turn predicted how quickly rats adapted to subsequent rule changes. The results suggest that task rules signaled by the mPFC become incorporated into hippocampal representations and support prospective coding. By this mechanism, mPFC activity prevents interference by "teaching" the hippocampus to retrieve distinct representations of similar circumstances.
[Mh] Termos MeSH primário: Região CA1 Hipocampal/fisiologia
Aprendizagem em Labirinto/fisiologia
Memória/fisiologia
Córtex Pré-Frontal/fisiologia
[Mh] Termos MeSH secundário: Animais
Agonistas de Receptores de GABA-A/farmacologia
Hipocampo/fisiologia
Aprendizagem/efeitos dos fármacos
Aprendizagem/fisiologia
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
Muscimol/farmacologia
Córtex Pré-Frontal/efeitos dos fármacos
Ratos
Aprendizagem Espacial/efeitos dos fármacos
Aprendizagem Espacial/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE


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[PMID]:28275709
[Au] Autor:Hamel L; Thangarasa T; Samadi O; Ito R
[Ad] Endereço:Department of Psychology (Scarborough), University of Toronto , 1265 Military Trail , Toronto, Ontario M1C 1A4, Canada.
[Ti] Título:Caudal Nucleus Accumbens Core Is Critical in the Regulation of Cue-Elicited Approach-Avoidance Decisions.
[So] Source:eNeuro;4(1), 2017 Jan-Feb.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The nucleus accumbens (NAc) is thought to be a site of integration of positively and negatively valenced information and action selection. Functional differentiation in valence processing has previously been found along the rostrocaudal axis of the shell region of the NAc in assessments of unconditioned motivation. Given that the core region of the NAc has been implicated in the elicitation of motivated behavior in response to conditioned cues, we sought to assess the role of caudal, intermediate, and rostral sites within this subregion in cue-elicited approach-avoidance decisions. Rats were trained to associate visuo-tactile cues with appetitive, aversive, and neutral outcomes. Following the successful acquisition of the cue-outcome associations, rats received microinfusions of GABA and GABA receptor agonists (muscimol/baclofen) or saline into the caudal, intermediate, or rostral NAc core and were then exposed to a superimposition of appetitively and aversively valenced cues versus neutral cues in a "conflict test," as well as to the appetitive versus neutral cues, and aversive cues versus neutral cues, in separate conditioned preference/avoidance tests. Disruption of activity in the intermediate to caudal parts of the NAc core resulted in a robust avoidance bias in response to motivationally conflicting cues, as well as a potentiated avoidance of aversive cues as compared with control animals, coupled with an attenuated conditioned preference for the appetitive cue. These results suggest that the caudal NAc core may have the capacity to exert bidirectional control over appetitively and aversively motivated responses to valence signals.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/fisiologia
Comportamento de Escolha/fisiologia
Sinais (Psicologia)
Núcleo Accumbens/fisiologia
[Mh] Termos MeSH secundário: Animais
Aprendizagem por Associação/efeitos dos fármacos
Aprendizagem por Associação/fisiologia
Aprendizagem da Esquiva/efeitos dos fármacos
Baclofeno/farmacologia
Comportamento de Escolha/efeitos dos fármacos
Condicionamento (Psicologia)/efeitos dos fármacos
Condicionamento (Psicologia)/fisiologia
Conflito (Psicologia)
Agonistas GABAérgicos/farmacologia
Masculino
Motivação/efeitos dos fármacos
Motivação/fisiologia
Muscimol/farmacologia
Núcleo Accumbens/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos Long-Evans
Receptores de GABA-A/metabolismo
Receptores de GABA-B/metabolismo
Percepção do Tato/efeitos dos fármacos
Percepção do Tato/fisiologia
Percepção Visual/efeitos dos fármacos
Percepção Visual/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA Agonists); 0 (Proto-Oncogene Proteins c-fos); 0 (Receptors, GABA-A); 0 (Receptors, GABA-B); 2763-96-4 (Muscimol); H789N3FKE8 (Baclofen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28232084
[Au] Autor:Cevikbas F; Braz JM; Wang X; Solorzano C; Sulk M; Buhl T; Steinhoff M; Basbaum AI
[Ad] Endereço:Department of Anatomy, University California San Francisco, San Francisco, Calif; Department of Dermatology, University California San Francisco, San Francisco, Calif.
[Ti] Título:Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.
[So] Source:J Allergy Clin Immunol;140(2):454-464.e2, 2017 Aug.
[Is] ISSN:1097-6825
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord gamma aminobutyric acidergic (GABAergic) inhibitory controls. OBJECTIVES: We sought to test the hypothesis that selective GABA agonists as well as cell transplant-derived GABA are antipruritic against acute itch and in a transgenic mouse model of atopic dermatitis produced by overexpression of the T 2 cell-associated cytokine, IL-31 (IL-31Tg mice). METHODS: We injected wild-type and IL-31Tg mice with combinations of GABA-A (muscimol) or GABA-B (baclofen) receptor agonists 15 to 20 minutes prior to injection of various pruritogens (histamine, chloroquine, or endothelin-1) and recorded spontaneous scratching before and after drug administration. We also tested the antipruritic properties of intraspinal transplantation of precursors of GABAergic interneurons in the IL-31Tg mice. RESULTS: Systemic muscimol or baclofen are antipruritic against both histamine-dependent and -independent pruritogens, but the therapeutic window using either ligand alone was very small. In contrast, combined subthreshold doses of baclofen and muscimol produced a significant synergistic antipruritic effect, with no sedation. Finally, transplant-mediated long-term enhancement of GABAergic signaling not only reduced spontaneous scratching in the IL-31Tg mice but also dramatically resolved the associated skin lesions. CONCLUSIONS: Although additional research is clearly needed, existing approved GABA agonists should be considered in the management of chronic itch, notably atopic dermatitis.
[Mh] Termos MeSH primário: Antipruriginosos/uso terapêutico
Baclofeno/uso terapêutico
Dermatite Atópica/tratamento farmacológico
Agonistas de Receptores de GABA-A/uso terapêutico
Agonistas dos Receptores de GABA-B/uso terapêutico
Muscimol/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Dermatite Atópica/metabolismo
Dermatite Atópica/terapia
Modelos Animais de Doenças
Sinergismo Farmacológico
Peptídeo Liberador de Gastrina/genética
Glutamato Descarboxilase/genética
Interleucinas/genética
Interneurônios/efeitos dos fármacos
Masculino
Eminência Mediana/citologia
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
RNA Mensageiro/metabolismo
Receptores da Bombesina/genética
Receptores de GABA-A/genética
Receptores de GABA-B/genética
Receptores da Neurocinina-1/genética
Pele/efeitos dos fármacos
Pele/patologia
Medula Espinal/efeitos dos fármacos
Medula Espinal/metabolismo
Transplante de Células-Tronco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipruritics); 0 (GABA-A Receptor Agonists); 0 (GABA-B Receptor Agonists); 0 (Interleukins); 0 (RNA, Messenger); 0 (Receptors, Bombesin); 0 (Receptors, GABA-A); 0 (Receptors, GABA-B); 0 (Receptors, Neurokinin-1); 0 (interleukin-31, mouse); 2763-96-4 (Muscimol); 80043-53-4 (Gastrin-Releasing Peptide); EC 4.1.1.15 (Glutamate Decarboxylase); EC 4.1.1.15 (glutamate decarboxylase 1); EC 4.1.1.15 (glutamate decarboxylase 2); H789N3FKE8 (Baclofen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE


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[PMID]:28230385
[Au] Autor:Campolattaro MM; Savage SW; Lipatova O
[Ad] Endereço:Department of Psychology, Christopher Newport University.
[Ti] Título:Auditory cue absence as a conditioned stimulus for delay eyeblink conditioning.
[So] Source:Behav Neurosci;131(2):149-54, 2017 04.
[Is] ISSN:1939-0084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present experiment was designed to determine if the absence of an auditory cue (i.e., a "tone-off" cue) would be an effective conditioned stimulus (CS) for delay eyeblink conditioning and to test if the medial geniculate nucleus (MGN) is part of the sensory pathway for tone-off conditioning. Rats were given paired or unpaired delay eyeblink conditioning to examine if responding to a tone-off CS was due to an associative process. An inactivation technique was performed on a separate group of rats to determine if the MGN is needed to express tone-off conditioning. The results showed that rats given paired conditioning acquired robust conditioned eyeblink responses (CRs) compared with rats given unpaired conditioning and that expression of tone-off elicited CRs was impaired when the MGN was inactivated. The findings suggest that tone-on and tone-off eyeblink conditioning may share a common neural pathway. (PsycINFO Database Record
[Mh] Termos MeSH primário: Estimulação Acústica
Aprendizagem por Associação
Condicionamento Palpebral
Sinais (Psicologia)
Corpos Geniculados/fisiologia
[Mh] Termos MeSH secundário: Animais
Aprendizagem por Associação/efeitos dos fármacos
Condicionamento Palpebral/efeitos dos fármacos
Agonistas de Receptores de GABA-A/administração & dosagem
Corpos Geniculados/efeitos dos fármacos
Masculino
Muscimol/administração & dosagem
Ratos
Ratos Long-Evans
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (GABA-A Receptor Agonists); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1037/bne0000188



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