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[PMID]: 25195536 [Au] Autor: Isozaki Y; Hoshino I; Akutsu Y; Hanari N; Mori M; Nishimori T; Murakami K; Akanuma N; Toyozumi T; Takahashi M; Suito H; Takeshita N; Maruyama T; Suzuki A; Nakayama T; Matsubara H [Ad] Endereço: Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan. [Ti] Título: Screening of alternative drugs to the tumor suppressor miR-375 in esophageal squamous cell carcinoma using the connectivity map. [So] Source: Oncology;87(6):351-63, 2014. [Is] ISSN: 1423-0232 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The aim of this study was to identify alternative compounds to the tumor suppressor miR-375 using the connectivity map (CMAP) and to validate the antitumor effects of the identified drugs in esophageal squamous cell carcinoma (ESCC). METHODS: Gene profiling of miR-375-treated TE2 and T.Tn cells was applied in order to search the CMAP database. Among the compounds identified using the CMAP, we focused on 8 drugs [(-)-epigallocatechin-3-gallate, metformin, rosiglitazone among others], excluding 2 drugs among the top 10 compounds. We evaluated whether these compounds possess tumor-suppressive functions in ESCC. RESULTS: A cytotoxicity assay showed that the sensitivity of TE2 and T.Tn cells treated with the 8 compounds was evaluated based on IC50 values of 42.9 µM to 3.8 mM. A cell cycle analysis revealed that the percentage of TE2 and T.Tn cells incubated with 6 compounds in the G0/G1 phase or the G2/M phase increased by approximately 40-80%. A TUNEL assay showed that the percentages of apoptotic cells treated with almost all compounds were significantly increased (p < 0.05) compared with the control cells. CONCLUSION: The CMAP database is a useful tool for identifying compounds affecting the same molecular pathways, particularly products that are difficult to apply via practical approaches, such as microRNAs. [Mh] Termos MeSH primário: Antineoplásicos/farmacologia Carcinoma de Células Escamosas/tratamento farmacológico Citotoxinas/farmacologia Neoplasias Esofágicas/tratamento farmacológico MicroRNAs/efeitos dos fármacos Proteínas Supressoras de Tumor/efeitos dos fármacos [Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos Benzocaína/farmacologia Betazol/farmacologia Catequina/análogos & derivados Catequina/farmacologia Linhagem Celular Tumoral/efeitos dos fármacos Ácido Quenodesoxicólico/farmacologia Primers do DNA Seres Humanos Marcação In Situ das Extremidades Cortadas Metformina/farmacologia MicroRNAs/metabolismo Nizatidina/farmacologia Organofosfatos/farmacologia Prolina/análogos & derivados Prolina/farmacologia Análise Serial de Proteínas Reação em Cadeia da Polimerase em Tempo Real Tiazolidinedionas/farmacologia Transcriptoma Transfecção Proteínas Supressoras de Tumor/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents); 0 (Cytotoxins); 0 (DNA Primers); 0 (MIRN375 microRNA, human); 0 (MicroRNAs); 0 (Organophosphates); 0 (Thiazolidinediones); 0 (Tumor Suppressor Proteins); 05V02F2KDG (rosiglitazone); 0GEI24LG0J (Chenodeoxycholic Acid); 124X2V25W4 (fosfosal); 1C065P542O (Betazole); 8R1V1STN48 (Catechin); 9100L32L2N (Metformin); 9DLQ4CIU6V (Proline); BQM438CTEL (epigallocatechin gallate); P41PML4GHR (Nizatidine); S1L688345C (stachydrine); U3RSY48JW5 (Benzocaine) [Em] Mês de entrada: 1501 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140909 [St] Status: MEDLINE [do] DOI: 10.1159/000365592

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[PMID]: 19302218 [Au] Autor: da Rocha JR; Ribeiro U; Cecconello I; Sallum RA; Takeda F; Nasi A; Szachnowicz S [Ad] Endereço: Digestive Surgery Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil. [Ti] Título: Gastric secretory and hormonal patterns in end-stage chagasic achalasia. [So] Source: Dis Esophagus;22(7):606-10, 2009. [Is] ISSN: 1442-2050 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Achalasia surgical treatment alters the esophagogastric junction anatomy (cardiomyotomy plus fundoplication or esophagectomy and gastric pull-up), thus favoring a certain degree of gastroesophageal reflux. Gastric secretory and hormonal functioning is not completely known in chagasic patients. The aim of this study was to evaluate the gastric secretory and hormonal response in patients with end-stage chagasic achalasia compared with normal subjects. Gastric secretion and hormonal response were assessed by estimation of gastric acid secretion (GAS) in basal condition and after pentagastrin stimulation, basal serum gastrin, and serum pepsinogen (SP) in basal condition and after betazole hydrochloride (Histalog; Eli Lilly and Company, Indianapolis, IN, USA) stimulation in 27 patients with chagasic achalasia. The results were then compared with those of 24 normal subjects. In the chagasic group, the mean basal and stimulated GAS were significantly lower than in the control group (basal: 1.277 vs. 3.13, P = 0.002; stimulated: 15.9 vs. 35.8, P = 0.0001). Chagasic patients' SG levels showed a significantly higher basal value than the control group (83.3 vs. 36.8, P = 0.0001). There was a significant increase of SP after stimulation compared with the basal levels in both chagasic and control groups. Although the chagasic patients' SP values were higher than the controls, this difference was not statistically significant, either in basal and stimulated conditions (basal: 122.0 vs. 108.9, stimulated 120 min: 177.1 vs. 158.9). In patients with chronic Chagas' disease (ChD), although autonomic denervation does not suppress the strength of the gastric mucosal cells' secretory response to stimulation, it reduces GAS (parietal cell) without, however, affecting SP production (chief cells). On the other hand, the gastrin-producing cells have continuously been stimulated by low GAS. [Mh] Termos MeSH primário: Doença de Chagas/fisiopatologia Acalasia Esofágica/fisiopatologia Ácido Gástrico/secreção [Mh] Termos MeSH secundário: Adulto Idoso Betazol/farmacologia Doença Crônica Acalasia Esofágica/parasitologia Acalasia Esofágica/cirurgia Feminino Determinação da Acidez Gástrica Agonistas dos Receptores Histamínicos/farmacologia Seres Humanos Masculino Meia-Idade Pepsinogênio A/sangue Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Histamine Agonists); 1C065P542O (Betazole); 9001-10-9 (Pepsinogen A) [Em] Mês de entrada: 1001 [Cu] Atualização por classe: 161020 [Lr] Data última revisão: 161020 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 090324 [St] Status: MEDLINE [do] DOI: 10.1111/j.1442-2050.2009.00961.x

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[PMID]: 9172476 [Au] Autor: Watanabe H; Ishida M; Hiraishi H; Terano A [Ad] Endereço: Second Department of Internal Medicine, Dokkyo University School of Medicine. [Ti] Título: [Investigation of gastric juice (gastrin stimulating test, Histalog stimulating test)]. [So] Source: Nihon Rinsho;55 Suppl 2:92-4, 1997 Apr. [Is] ISSN: 0047-1852 [Cp] País de publicação: Japan [La] Idioma: jpn [Mh] Termos MeSH primário: Betazol Suco Gástrico/secreção Gastrinas [Mh] Termos MeSH secundário: Úlcera Duodenal/diagnóstico Determinação da Acidez Gástrica Gastrite/diagnóstico Seres Humanos Neoplasias Gástricas/diagnóstico Úlcera Gástrica/diagnóstico Síndrome de Zollinger-Ellison/diagnóstico [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Gastrins); 1C065P542O (Betazole) [Em] Mês de entrada: 9708 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 970401 [St] Status: MEDLINE

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[PMID]: 8975987 [Au] Autor: Engler-Pinto Júnior P; Gama-Rodrigues J; Lopasso FP; Cordeiro AC; Saez-Alquezar A; Laudanna AA; Pinotti HW [Ad] Endereço: Department of Gastroenterology, Sao Paulo Faculty of Medicine, Brazil. [Ti] Título: Site of peptic ulcer. comparison of hydrochloric acid output, pepsinogen and gastrin serum levels. [So] Source: Hepatogastroenterology;43(12):1671-7, 1996 Nov-Dec. [Is] ISSN: 0172-6390 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIMS: Basal (BAO) and maximum (PAO) hydrochloric acid output after Histalog stimulation, basal pepsinogen (SPL-B), at 60 (SPL-60) and at 90 minutes (SPL-90), and basal gastrin (BG) levels were measured and compared in different gastric (GU) and duodenal (DU) ulcer sites. MATERIAL AND METHODS: Fifty nine patients with peptic ulcer were grouped according to Johnson's classification for gastric ulcers: type I (15), type II (16) type III (12) GU and (16) DU. Fifteen normal subjects were studied as controls. RESULTS: The BAO was greater in the DU than in the control or GU groups. No significant difference was noted in the production of hydrochloric acid after stimulation with Histalog. The SPL-B, at 60 and at 90 minutes was higher in type II GU than in the DU group and controls. The SPL-60 was higher in type II GU patients than in type III GU. Basal gastrin was higher in group DU and types II and III GU compared to the type I GU patients and controls. CONCLUSION: The topographic criteria for differentiating peptic ulcers has low discrimination capacity based on comparison of mean values of HCl acid production, pepsinogen and gastrin serum levels both basal and after stimulation with Histalog due to heterogeneity of these variables in group studies. In these studies, peptic ulcers from different sites should not be grouped as distinct entities except for type II gastric ulcers. [Mh] Termos MeSH primário: Gastrinas/sangue Ácido Clorídrico/metabolismo Pepsinogênios/sangue Úlcera Péptica/classificação Úlcera Péptica/metabolismo [Mh] Termos MeSH secundário: Betazol Feminino Fármacos Gastrointestinais Seres Humanos Masculino Meia-Idade Fatores de Tempo [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Gastrins); 0 (Gastrointestinal Agents); 0 (Pepsinogens); 1C065P542O (Betazole); QTT17582CB (Hydrochloric Acid) [Em] Mês de entrada: 9703 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 961101 [St] Status: MEDLINE

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[PMID]: 2084190 [Au] Autor: Xu RJ; Cranwell PD [Ad] Endereço: School of Agriculture, La Trobe University, Bundoora, Victoria, Australia. [Ti] Título: Development of gastric acid secretion in pigs from birth to thirty six days of age: the response to pentagastrin. [So] Source: J Dev Physiol;13(6):315-26, 1990 Jun. [Is] ISSN: 0141-9846 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The development of the gastric acid secretory response to pentagastrin was studied using 56 Large White x Landrace pigs, 0-36 days of age, 1.1-13.3 kg body-weight, obtained from 12 litters. Gastric acid secretory capacity was measured using a gastric perfusion technique and intravenous infusion of pentagastrin at dose rates of 2, 4 and 8 micrograms/h per kg. Significant positive linear correlations were found between stomach weight and age, and between stomach weight and body-weight during the 36 day period. The stomach weight to body-weight ratio increased for the first 3 days of age and then decreased during the following 33 days. Basal acid secretion was detected in all unsuckled pigs (n = 9), 2- to 8-h old. Maximal acid outputs in response to pentagastrin in these pigs were 0.16 +/- 0.02 mmol/kg body-weight and 0.034 +/- 0.001 mmol/g stomach weight. For the 56 pigs, significant linear correlations were found between maximal acid output and age, maximal acid output and body-weight, and maximal acid output and stomach weight. There was a significant linear increase in maximal acid output per unit stomach weight during the first 7 days of age, but during the subsequent 29 days the pattern of increase in gastric secretory capacity was slower and curvilinear. In the oldest nine pigs, 24-36 days of age, maximal acid outputs were 0.974 +/- 0.058 mmol/kg body-weight and 0.234 +/- 0.016 mmol/g stomach weight which represents a six to seven-fold increase compared with those determined in pigs at birth. Comparison of gastric acid secretory capacity determined under anaesthesia with that in conscious pigs showed that anaesthesia appeared to suppress basal output but had no effect on pentagastrin stimulated output. Comparison of response to histalog (betazole HCl) and pentagastrin indicated that newborn pigs were more sensitive to histalog but in pigs 9-38 days of age, there were no significant differences in responsiveness to the two secretagogues. These results show that gastric sensitivity to pentagastrin increases rapidly in the first week of life, that the stomach of the newborn pig is more sensitive to histalog than pentagastrin and that studies of the effect of pentagastrin on acid secretion, done under anaesthesia, are comparable to those in the conscious pig. [Mh] Termos MeSH primário: Envelhecimento/metabolismo Ácido Gástrico/secreção Mucosa Gástrica/secreção Pentagastrina/farmacologia Suínos/metabolismo [Mh] Termos MeSH secundário: Animais Animais Recém-Nascidos/metabolismo Animais Lactentes/metabolismo Betazol/farmacologia Peso Corporal Mucosa Gástrica/efeitos dos fármacos Infusões Intravenosas/veterinária Tamanho do Órgão Pentagastrina/administração & dosagem Perfusão/veterinária Análise de Regressão [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 1C065P542O (Betazole); EF0NX91490 (Pentagastrin) [Em] Mês de entrada: 9105 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 900601 [St] Status: MEDLINE

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[PMID]: 2770681 [Au] Autor: Eto S [Ad] Endereço: Second Department of Surgery, Yokohama City University School of Medicine, Japan. [Ti] Título: [Changes in gastric mucosal blood flow after selective proximal vagotomy; an experimental study in rats]. [So] Source: Nihon Geka Gakkai Zasshi;90(3):377-84, 1989 Mar. [Is] ISSN: 0301-4894 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: The effect of selective proximal vagotomy (SPV) on gastric mucosal blood flow (MBF) was studied in rats using hydrogen gas clearance technique. The following results were obtained. 1) Resting MBF of the corpus decreased significantly from 106.3 +/- 9.8 ml/min/100g to 74.5 +/- 15.5 ml/min/100g at 12 weeks after SPV (p less than 0.01). Resting MBF of the antrum did not decrease. 2) Tetragastrin, betazol-HCl and 2-deoxy-d-glucose (2DG)-stimulated acid outputs were reduced following SPV for more than 12 weeks after operation. 3) The increase of corporal MBF after tetragastrin, betazol-HCl and 2DG stimulation was less significant with accompanying reduction of acid output. 4) The increase of antral MBF after tetragastrin or betazol-HCl stimulation was less significant after SPV. But, the increase after 2DG stimulation was as much as after SPV. [Mh] Termos MeSH primário: Mucosa Gástrica/irrigação sanguínea Vagotomia Gástrica Proximal [Mh] Termos MeSH secundário: Animais Betazol Desoxiglucose Ácido Gástrico/secreção Mucosa Gástrica/efeitos dos fármacos Mucosa Gástrica/secreção Hidrogênio/análise Masculino Antro Pilórico Ratos Ratos Endogâmicos Fluxo Sanguíneo Regional/efeitos dos fármacos Tetragastrina [Pt] Tipo de publicação: ENGLISH ABSTRACT; JOURNAL ARTICLE [Nm] Nome de substância: 0OL293AV80 (Tetragastrin); 1C065P542O (Betazole); 7YNJ3PO35Z (Hydrogen); 9G2MP84A8W (Deoxyglucose) [Em] Mês de entrada: 8909 [Cu] Atualização por classe: 151119 [Lr] Data última revisão: 151119 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 890301 [St] Status: MEDLINE

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[PMID]: 2751732 [Au] Autor: Pinelli A; Trivulzio S; Malvezzi L; Rossoni G; Beretta L [Ad] Endereço: Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Italy. [Ti] Título: 2-substituted derivatives of benzimidazole inhibiting gastric acid secretion in rats. [So] Source: Arzneimittelforschung;39(4):467-9, 1989 Apr. [Is] ISSN: 0004-4172 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Benzimidazole and its 2-derivatives with amino, carbamonitrile, urea, and guanidine groups have been tested for their activity on gastric secretory process. The carbamonitrile-, urea-, and guanidine compounds decrease gastric acid secretion, basal and stimulated with histamine or betazole, in Shay-rats and depress the guinea pig auricle activity stimulated by betazole. The results suggest that the studied 2-substituted benzimidazole compounds exhibit anti H2-histamine activity. [Mh] Termos MeSH primário: Benzimidazóis/farmacologia Ácido Gástrico/secreção [Mh] Termos MeSH secundário: Animais Betazol/farmacologia Determinação da Acidez Gástrica Cobaias Coração/efeitos dos fármacos Histamina/farmacologia Técnicas In Vitro Masculino Ratos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Benzimidazoles); 1C065P542O (Betazole); 820484N8I3 (Histamine) [Em] Mês de entrada: 8908 [Cu] Atualização por classe: 141120 [Lr] Data última revisão: 141120 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 890401 [St] Status: MEDLINE

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[PMID]: 2625397 [Au] Autor: D'Albuquerque LA; Rodrigues JG; Albornoz P; De Miranda MP; Genzini T; Pinotti HW [Ad] Endereço: Department of Gastroenterology, of School of Medicine of University of São Paulo, Brazil. [Ti] Título: Serum pepsinogen before and after proximal gastric vagotomy in duodenal ulcer treatment. [So] Source: Int Surg;74(4):229-31, 1989 Oct-Dec. [Is] ISSN: 0020-8868 [Cp] País de publicação: Italy [La] Idioma: eng [Ab] Resumo: Serum pepsinogen (SP) behavior was evaluated under basal conditions and under betazole stimulation in 59 patients: 14 controls, nine unoperated duodenal ulcers (DU) and 36 DU after proximal gastric vagotomy (PGV), 14 with and 22 without recurrent ulcer. The mean follow-up of the 36 patients who underwent PGV was 38.7 months. SP was higher in unoperated DU than in the control group (p less than 0.05). After PGV in DU, there is a significant decrease of SP for both the patients with and without recurrent ulcer (p less than 0.05), being statistically similar to the control group. No difference of SP was observed between DU with and without recurrent ulcer after PGV. We concluded that SP can differentiate normal subjects from DU patients, although it is not a sensitive indicator of recurrent ulcer after PGV. [Mh] Termos MeSH primário: Úlcera Duodenal/cirurgia Pepsinogênios/sangue Vagotomia Gástrica Proximal [Mh] Termos MeSH secundário: Adulto Idoso Betazol/metabolismo Úlcera Duodenal/sangue Seguimentos Determinação da Acidez Gástrica Seres Humanos Meia-Idade Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Pepsinogens); 1C065P542O (Betazole) [Em] Mês de entrada: 9004 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 891001 [St] Status: MEDLINE

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[PMID]: 2591872 [Au] Autor: Imai T [Ad] Endereço: Department of Anesthesiology, Hokkaido University School of Medicine, Sapporo, Japan. [Ti] Título: [Influences of respiratory frequency on breathing mechanics during artificial ventilation in man and animal]. [So] Source: Hokkaido Igaku Zasshi;64(5):597-605, 1989 Sep. [Is] ISSN: 0367-6102 [Cp] País de publicação: Japan [La] Idioma: jpn [Ab] Resumo: Effects of respiratory frequency on breathing mechanics were examined on 11 surgical patients during artificial ventilation with inhalation of nitrous oxide, oxygen and halothane (GOF). When the respiratory frequency was increased stepwise from 10 to 30/min, the total compliance was significantly reduced stepwise (from 55.42 +/- 9.55 ml/cmH2O to 47.38 +/- 9.31, p less than 0.01). In animal experiment, the respiratory frequency was similarly increased from 10 to 30/min in 11 mongrel dogs under sodium thiamylal anesthesia with air breathing. The total pulmonary compliance decreased significantly from a control level of 13.62 +/- 5.04 ml/cmH2O to a value of 10.96 +/- 3.00 ml/cmH2O which was obtained under the administration of synthetic histamine (betazole hydrochloride) (p less than 0.01). However, the decreases in compliance with histamine were parallel with the control values without the drug treatment. From these results it was assumed that the reduction of the total pulmonary compliance under increased respiratory frequency was due not to changes in small airway but to those in large airway. [Mh] Termos MeSH primário: Anestesia por Inalação Complacência Pulmonar Respiração Artificial [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Animais Betazol/farmacologia Pressão Sanguínea/efeitos dos fármacos Cães Feminino Histamina/farmacologia Seres Humanos Complacência Pulmonar/efeitos dos fármacos Masculino Meia-Idade Respiração/efeitos dos fármacos [Pt] Tipo de publicação: ENGLISH ABSTRACT; JOURNAL ARTICLE [Nm] Nome de substância: 1C065P542O (Betazole); 820484N8I3 (Histamine) [Em] Mês de entrada: 9001 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 890901 [St] Status: MEDLINE

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[PMID]: 3211991 [Au] Autor: Trivulzio S [Ad] Endereço: Department of Pharmacology Chemotherapy and Medical Toxicology, University of Milan. [Ti] Título: Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats. [So] Source: Pharmacol Res Commun;20(12):1035-46, 1988 Dec. [Is] ISSN: 0031-6989 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: 2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects. The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole. The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pilocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine. BIU probably depresses gastric acid secretion by interfering with both histamine and acetylcholine receptors. [Mh] Termos MeSH primário: Ácido Gástrico/secreção Ureia/análogos & derivados [Mh] Termos MeSH secundário: Acetilcolina/farmacologia Animais Betazol/farmacologia Gatos Duodeno/efeitos dos fármacos Duodeno/fisiologia Feminino Motilidade Gastrointestinal/efeitos dos fármacos Cobaias Íleo/fisiologia Masculino Contração Miocárdica/efeitos dos fármacos Pilocarpina/farmacologia Ratos Traqueia/fisiologia Ureia/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 01MI4Q9DI3 (Pilocarpine); 1C065P542O (Betazole); 24370-25-0 (2-benzimidazolylurea); 8W8T17847W (Urea); N9YNS0M02X (Acetylcholine) [Em] Mês de entrada: 8902 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 881201 [St] Status: MEDLINE

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