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[PMID]:29374698
[Au] Autor:Bundscherer AC; Malsy M; Gruber MA; Graf BM; Sinner B
[Ad] Endereço:Department of Anesthesiology, University of Regensburg, Regensburg, Germany anika.bundscherer@ukr.de.
[Ti] Título:Acetaminophen and Metamizole Induce Apoptosis in HT 29 and SW 480 Colon Carcinoma Cell Lines .
[So] Source:Anticancer Res;38(2):745-751, 2018 02.
[Is] ISSN:1791-7530
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:BACKGROUND/AIM: The perioperative phase is supposed to be a period with high vulnerability for cancer dissemination. Acetaminophen and metamizole are common analgesics administered during this phase. We investigated the effect of acetaminophen, metamizole and 4-methylaminoantipyrine (MAA) on proliferation and apoptosis of colon carcinoma cell lines (SW 480 and HT 29). MATERIALS AND METHODS: Proliferation was detected by cell proliferation ELISA BrdU, and apoptosis by Annexin V staining. Cytochrome c and caspase 3, 8 and 9 expression levels were detected by western blot. RESULTS: Acetaminophen, metamizole or MAA caused slight changes in proliferation. Acetaminophen, metamizole or the combination increased apoptosis in both cell lines. All agents decreased caspase 3 and 8 expression in SW480. Acetaminophen decreased caspase 9 expression in both cell lines. CONCLUSION: In clinically relevant doses, acetaminophen and/or metamizole induce apoptosis in both colon cancer cell lines. Both mitochondrial and death receptor pathways might be involved in acetaminophen-induced apoptosis.
[Mh] Termos MeSH primário: Acetaminofen/farmacologia
Analgésicos não Entorpecentes/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias do Colo/tratamento farmacológico
Dipirona/farmacologia
[Mh] Termos MeSH secundário: Aminopirina/análogos & derivados
Aminopirina/farmacologia
Anti-Inflamatórios não Esteroides/farmacologia
Western Blotting
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/patologia
Células HT29
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Non-Narcotic); 0 (Anti-Inflammatory Agents, Non-Steroidal); 01704YP3MO (Aminopyrine); 362O9ITL9D (Acetaminophen); 6429L0L52Y (Dipyrone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180129
[St] Status:MEDLINE


  2 / 3257 MEDLINE  
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[PMID]:28254718
[Au] Autor:Leal M; Martínez-Hernández V; Meffe R; Lillo J; de Bustamante I
[Ad] Endereço:University Rey Juan Carlos, ESCET, Biology and Geology, Physics and Inorganic Chemistry Department, C/Tulipán s/n, 28933 Madrid, Spain; IMDEA Water, Avda. Punto Com, 2, 28805, Alcalá de Henares, Madrid, Spain. Electronic address: maria.leal@urjc.es.
[Ti] Título:Clinoptilolite and palygorskite as sorbents of neutral emerging organic contaminants in treated wastewater: Sorption-desorption studies.
[So] Source:Chemosphere;175:534-542, 2017 May.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Water reuse for aquifer recharge could be an important route for the introduction of emerging organic contaminants (EOCs) into the environment. The installation of a Horizontal Permeable Reactive Barrier (H-PRB) could constitute a tertiary treatment process to remove EOCs from treated domestic wastewater prior to recharge activities. The sorption-desorption behaviour of six neutral EOCs present in treated domestic wastewater (acetaminophen, caffeine, carbamazepine, cotinine, 4-acetamidoantipyrine (4-AAA) and 4-formylaminoantipyrine (4-FAA)) has been evaluated. Clinoptilolite and palygorskite have been studied as sorbents to be installed in the H-PRB. Batch tests were carried out using an EOC initial concentration ranging from 5 to 100 µg L . Apart from acetaminophen and caffeine, both materials showed a limited sorption capacity of neutral EOCs (K = 0.63-5.42 L kg ). In general, the experimental results show that EOCs exhibit a higher sorption affinity for clinoptilolite than for palygorskite. With the exception of carbamazepine, the sorption of the compounds occurs mainly by interactions with mineral surfaces as indicated by the comparison of the partition coefficients into organic matter and into mineral surfaces. According to the molecular geometry of the compounds and the sorption sequences observed, it appears that the dimensions of the organic molecules play a key role in the sorption process. All the studied EOCs exhibit irreversible sorption and sorption-desorption hysteresis.
[Mh] Termos MeSH primário: Compostos de Magnésio/química
Preparações Farmacêuticas/análise
Compostos de Silício/química
Águas Residuais/química
Poluentes Químicos da Água/análise
Purificação da Água/métodos
Zeolitas/química
[Mh] Termos MeSH secundário: Adsorção
Aminopirina/análogos & derivados
Aminopirina/análise
Água Subterrânea/química
Modelos Teóricos
Espanha
Propriedades de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Magnesium Compounds); 0 (Pharmaceutical Preparations); 0 (Silicon Compounds); 0 (Waste Water); 0 (Water Pollutants, Chemical); 01704YP3MO (Aminopyrine); 12173-10-3 (clinoptilolite); 1318-02-1 (Zeolites); 1672-58-8 (4-formylaminoantipyrine); U6V729APAM (attapulgite)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


  3 / 3257 MEDLINE  
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[PMID]:28056449
[Au] Autor:Cai MQ; Feng L; Zhang LQ
[Ad] Endereço:Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China.
[Ti] Título:Transformation of aminopyrine in the presence of free available chlorine: Kinetics, products, and reaction pathways.
[So] Source:Chemosphere;171:625-634, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aminopyrine (AMP) has been frequently detected in the aquatic environment. In this study, the transformation mechanism of AMP by free available chlorine (FAC) oxidation was investigated. The results showed that FAC reacted with AMP rapidly, and a 74% elimination was achieved for 1.30 µM AMP after 2 min at 14.08 µM FAC dose. AMP chlorination was strongly pH-dependent, and its reaction included second- and third-order kinetic processes. Three active FAC species, including chlorine monoxide (Cl O), molecular chlorine (Cl ), and hypochlorous acid (HOCl), were observed to contribute to AMP degradation. The intrinsic rate constants of each FAC species with neutral (AMP ) and cation (AMP ) species were obtained by kinetic fitting. Cl O exhibited the highest reactivity with AMP (k = (4.33 ± 1.4) × 10 M s ). In addition, Cl showed high reactivity (10 -10 M s ) in the presence of chloride, compared with HOCl (k = (5.73 ± 0.23) × 10 M s , k = (9.68 ± 0.96) × 10 M s ). At pH 6.15 and 14.08 µM FAC dose without chloride addition, the contribution of Cl O reached to the maximum (33.3%), but in the whole pH range, HOCl was the main contributor (>66.6%) for AMP degradation. The significance of Cl was noticeable in water containing chloride. Moreover, 11 transformation products were identified, and the main transformation pathways included pyrazole ring breakage, hydroxylation, dehydrogenation, and halogenation.
[Mh] Termos MeSH primário: Aminopirina/química
Cloro/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Compostos Clorados/química
Halogenação
Concentração de Íons de Hidrogênio
Hidroxilação
Ácido Hipocloroso/química
Cinética
Oxirredução
Purificação da Água/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorine Compounds); 0 (Water Pollutants, Chemical); 01704YP3MO (Aminopyrine); 12301-79-0 (chlorosyl); 4R7X1O2820 (Chlorine); 712K4CDC10 (Hypochlorous Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


  4 / 3257 MEDLINE  
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[PMID]:28057172
[Au] Autor:Niwa T; Imagawa Y
[Ad] Endereço:School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Naka-ku, Okayama 703-8516, Japan.
[Ti] Título:Substrate Specificity of Human Cytochrome P450 (CYP) 2C Subfamily and Effect of Azole Antifungal Agents on CYP2C8.
[So] Source:J Pharm Pharm Sci;19(4):423-429, 2016 Oct - Dec.
[Is] ISSN:1482-1826
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The metabolic activities of aminopyrine N-demethylation and tolbutamide methylhydroxylation by the human hepatic cytochrome P450 (P450 or CYP) 2C subfamily were compared and the effects of azole antifungal agent on the drug-metabolizing activity of CYP2C8 were investigated. METHODS: Aminopyrine N-demethylation and tolbutamide methylhydroxylation by CYP2C8, CYP2C9, and CYP2C19 were determined by the previous reported methods. The effects of five azole antifungal agents, fluconazole, itraconazole, ketoconazole, miconazole, and voriconazole, on the aminopyrine N-demethylation activity by CYP2C8 were investigated. RESULTS: With regard to aminopyrine N-demethylation, CYP2C19 had the lowest Michaelis constant (Km) and CYP2C8 had the highest maximal velocity (Vmax) among the CYP2C subfamily members. The Vmax/Km values for CYP2C8 were the highest, followed by CYP2C19. For tolbutamide methylhydroxylation, the Km and Vmax for CYP2C19 were three and six times higher than the corresponding values for CYP2C9, and the Vmax/Km value for CYP2C19 was twice that for CYP2C9, whereas hydroxylated tolbutamide formed by CYP2C8 was not detected. Fluconazole, itraconazole, and voriconazole at a concentration of 2 or 10 µM neither inhibited nor stimulated CYP2C8-mediated aminopyrine N-demethylation activity at substrate concentrations around the Km (5 mM). However, ketoconazole and miconazole noncompetitively inhibited CYP2C8-mediated aminopyrine N-demethylation with the inhibitory constant values of 1.98 and 0.86 µM, respectively. CONCLUSION: These results suggest that ketoconazole and miconazole might inhibit CYP2C8 clinically. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
[Mh] Termos MeSH primário: Aminopirina/farmacologia
Antifúngicos/farmacologia
Azóis/farmacologia
Inibidores das Enzimas do Citocromo P-450/farmacologia
Sistema Enzimático do Citocromo P-450/metabolismo
Tolbutamida/farmacologia
[Mh] Termos MeSH secundário: Aminopirina/química
Antifúngicos/química
Azóis/química
Inibidores das Enzimas do Citocromo P-450/química
Relação Dose-Resposta a Droga
Seres Humanos
Relação Estrutura-Atividade
Especificidade por Substrato
Tolbutamida/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Azoles); 0 (Cytochrome P-450 Enzyme Inhibitors); 0 (cytochrome P-450 CYP2C subfamily); 01704YP3MO (Aminopyrine); 9035-51-2 (Cytochrome P-450 Enzyme System); 982XCM1FOI (Tolbutamide)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170107
[St] Status:MEDLINE
[do] DOI:10.18433/J31S53


  5 / 3257 MEDLINE  
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[PMID]:27803471
[Au] Autor:Uchida T; Nishioka K; Motoki A; Yakumaru M; Sano T; Todo H; Sugibayashi K
[Ad] Endereço:Skin Care Products Research, Kao Corporation.
[Ti] Título:Effect of Esters on the Permeation of Chemicals with Different Polarities through Synthetic Artificial Membranes Using a High-Throughput Diffusion Cell Array.
[So] Source:Chem Pharm Bull (Tokyo);64(11):1597-1606, 2016.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This study investigated the effects of 25 kinds of esters that are used in cosmetics on the permeation of four model compounds with different polarities (caffeine [CF], aminopyrine [AMP], benzoic acid [BA], and flurbiprofen [FP]). The amount of each model compound that permeated through two types of artificial membrane (silicone and Strat-M ) was measured and correlated with the physicochemical properties of the esters, including their solubility, viscosity, wettability, surface tension, and uptake. The amount of each model compound that permeated through the silicone membrane was not significantly correlated with the solubility of the esters but was significantly correlated with all other measured physical properties of the esters. Similar correlations were observed for the amounts of AMP, BA, and FP that passed through the Strat-M membrane. However, the amount of CF that permeated through the Strat-M membrane also correlated with the solubility of the esters. There was a highly significant correlation between the amount permeating through the silicone and Strat-M membranes because the model compounds had high lipophilicity. These findings demonstrated that to control the permeation of various chemicals through artificial membranes, it is important to consider the uptake of the esters and that the solubility of the esters is also an important consideration when using a more complex membrane.
[Mh] Termos MeSH primário: Cosméticos/química
Ésteres/química
Ensaios de Triagem em Larga Escala
Membranas Artificiais
Silicones/química
[Mh] Termos MeSH secundário: Aminopirina/química
Ácido Benzoico/química
Cafeína/química
Difusão
Flurbiprofeno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cosmetics); 0 (Esters); 0 (Membranes, Artificial); 0 (Silicones); 01704YP3MO (Aminopyrine); 3G6A5W338E (Caffeine); 5GRO578KLP (Flurbiprofen); 8SKN0B0MIM (Benzoic Acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170124
[Lr] Data última revisão:
170124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161103
[St] Status:MEDLINE


  6 / 3257 MEDLINE  
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[PMID]:27689198
[Au] Autor:Lebossé F; Guillaud O; Forestier J; Ecochard M; Boillot O; Roman S; Mion F; Dumortier J
[Ad] Endereço:Digestive Physiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
[Ti] Título:Prognostic Value of Metabolic Liver Function Tests: a Study on 711 Cirrhotic Patients.
[So] Source:J Gastrointestin Liver Dis;25(3):337-43, 2016 Sep.
[Is] ISSN:1842-1121
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: The prognosis of cirrhotic patients is usually assessed by Child-Pugh and MELD scores. Metabolic liver function tests such as aminopyrine breath test (ABT) and indocyanine green clearance (IGC) have been shown to reveal hepatocellular dysfunction. The aim of this retrospective study was to compare the prognostic value of the MELD score, Child-Pugh score, ABT and IGC in a large cohort of cirrhotic patients. METHODS: Between January 1996 and June 2008, 711 cirrhotic patients were included and the primary endpoint was survival without LT. The ROC curves with c-statistics, correlation coefficient and survival were calculated. RESULTS: Metabolic function tests and scores were strongly correlated. At the time of evaluation, 111 patients had died and 520 had received a transplant. Prognostic ability (estimated by the AUROC curve) to predict survival without LT at 6 months was 0.662, 0.691, 0.738 and 0.715 for ABT, IGC, Child-Pugh score and MELD score, respectively. Similarly, at 1 year, AUROC was 0.738 for Child-Pugh score, 0.716 for MELD score, 0.693 for IGC clearance and 0.651 for ABT. CONCLUSIONS: Our results strongly confirm that IGC and ABT have a high prognostic value in cirrhotic patients, similar to Child-Pugh and MELD scores. They could be developed to routinely evaluate the prognosis of patients in addition to clinical and biochemical data.
[Mh] Termos MeSH primário: Aminopirina/metabolismo
Testes Respiratórios
Corantes/administração & dosagem
Técnicas de Apoio para a Decisão
Verde de Indocianina/administração & dosagem
Cirrose Hepática/diagnóstico
Testes de Função Hepática/métodos
Fígado/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Área Sob a Curva
Biomarcadores/metabolismo
Corantes/farmacocinética
Feminino
Seres Humanos
Verde de Indocianina/farmacocinética
Estimativa de Kaplan-Meier
Cirrose Hepática/metabolismo
Cirrose Hepática/mortalidade
Cirrose Hepática/cirurgia
Transplante de Fígado
Masculino
Meia-Idade
Valor Preditivo dos Testes
Prognóstico
Curva ROC
Reprodutibilidade dos Testes
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Coloring Agents); 01704YP3MO (Aminopyrine); IX6J1063HV (Indocyanine Green)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170228
[Lr] Data última revisão:
170228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.15403/jgld.2014.1121.253.lft


  7 / 3257 MEDLINE  
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[PMID]:27452991
[Au] Autor:Li Y; Wang J; Zhan L; Wleklinski M; Wang J; Xiong C; Liu H; Zhou Y; Nie Z
[Ad] Endereço:Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry Chinese Academy of Sciences, Beijing 100190, China; Beijing National Laboratory for Molecular Sciences, Beijing 100190, China.
[Ti] Título:The bridge between thin layer chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry: The realization of liquid thin layer chromatography-mass spectrometry (LTLC-MS).
[So] Source:J Chromatogr A;1460:181-9, 2016 Aug 19.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The combination of thin layer chromatography (TLC) and mass spectrometry (MS) has been studied for decades, but for most cases MS detection is done after TLC separation is finished. Here, an online simultaneous TLC-MS analysis system, liquid thin layer chromatography-mass spectrometry (LTLC-MS), is developed which successfully synchronize TLC separation process and MS detection process like GC-MS and HPLC-MS do. And there's no need to use specially designed TLC, just regular TLC plates are enough. LTLC-MS method is composed of a newly developed ambient ionization method, glow discharge-matrix assisted infrared desorption ionization (GD-MAIRDI), and forced-flow TLC (FFTLC) technique, which guarantees the MS detection process does not disturb the TLC separation process throughout the whole analysis. The whole LTLC-MS analysis only need two steps and less than 15min. Mixtures as well as the two main components of a pain relief pills have been successfully analyzed by LTLC-MS. This proof of concept study opens up new possibilities of combining TLC with MS, and will further broaden the application abilities of TLC.
[Mh] Termos MeSH primário: Analgésicos/análise
Cromatografia Líquida de Alta Pressão/métodos
Cromatografia em Camada Delgada/métodos
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/métodos
[Mh] Termos MeSH secundário: Aminopirina/análise
Analgésicos/química
Cromatografia Líquida de Alta Pressão/instrumentação
Cromatografia em Camada Delgada/instrumentação
Fenacetina/análise
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz/instrumentação
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Tablets); 01704YP3MO (Aminopyrine); ER0CTH01H9 (Phenacetin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


  8 / 3257 MEDLINE  
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[PMID]:27030298
[Au] Autor:Ariza A; García-Martín E; Salas M; Montañez MI; Mayorga C; Blanca-Lopez N; Andreu I; Perkins J; Blanca M; Agúndez JA; Torres MJ
[Ad] Endereço:Research Laboratory, IBIMA-Regional University Hospital of Malaga-UMA, Malaga, Spain.
[Ti] Título:Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole.
[So] Source:Sci Rep;6:23845, 2016 Mar 31.
[Is] ISSN:2045-2322
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common cause of hypersensitivity reactions, with pyrazolones the most frequent drugs inducing selective reactions. Immediate selective hypersensitivity to pyrazolones is thought to be mediated by specific-IgE. Sensitivity of in vitro diagnostic tests is low and this may be due to the incomplete characterization of the structures involved. Here we investigated whether main metabolites of metamizole (dipyrone) in human could be involved in the immune response using the basophil activation test (BAT). We studied subjects with confirmed selective immediate hypersensitivity to metamizole and performed BAT with metamizole and its metabolites: 4-methylamino-antipyrine (MAA), 4-aminoantipyrine (AA), 4-acetylamino-antipyrine (AAA) and 4-formylamino-antipyrine (FAA). BAT results showed an increase of positive results from 37.5% to 62.5% using metamizole plus metabolites as compared with the BAT carried out only with the parent drug, demonstrating that metamizole metabolites have a role in the reaction and can induce specific basophil activation in patients with immediate hypersensitivity to this drug. Our findings indicate that pyrazolone metabolites are useful for improving the in vitro diagnosis of allergic reactions to metamizole.
[Mh] Termos MeSH primário: Anafilaxia/induzido quimicamente
Anti-Inflamatórios não Esteroides/efeitos adversos
Basófilos/efeitos dos fármacos
Dipirona/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Aminopirina/análogos & derivados
Aminopirina/metabolismo
Aminopirina/farmacologia
Ampirona/análogos & derivados
Ampirona/metabolismo
Ampirona/farmacologia
Anafilaxia/imunologia
Anafilaxia/fisiopatologia
Anti-Inflamatórios não Esteroides/metabolismo
Teste de Degranulação Basófila
Basófilos/imunologia
Biotransformação
Estudos de Casos e Controles
Dipirona/metabolismo
Feminino
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Cultura Primária de Células
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 01704YP3MO (Aminopyrine); 0M0B7474RA (Ampyrone); 1672-58-8 (4-formylaminoantipyrine); 6429L0L52Y (Dipyrone); 83-15-8 (N-acetylaminoantipyrine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160401
[St] Status:MEDLINE
[do] DOI:10.1038/srep23845


  9 / 3257 MEDLINE  
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[PMID]:26434939
[Au] Autor:Park JA; Zhang D; Kim SK; Cho SH; Cho SM; Yi H; Shim JH; Kim JS; Abd El-Aty AM; Shin HC
[Ad] Endereço:Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
[Ti] Título:Simultaneous determination of aminopyrine and antipyrine in porcine muscle, milk, and eggs using liquid chromatography with tandem mass spectrometry.
[So] Source:J Sep Sci;38(23):4048-54, 2015 Dec.
[Is] ISSN:1615-9314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The concentrations of residual aminopyrine and antipyrine in porcine muscle, milk, and egg samples were analyzed using liquid chromatography with tandem mass spectrometry after undergoing a series of sample pretreatment steps. Owing to an ion suppression effect, matrix-matched calibrations were used for analyte quantitation with determination coefficients (R(2) ) ≥ 0.9931. The recovery rates for aminopyrine and antipyrine in various matrices at two spiking levels (5 and 10 ng/g) fell in the range of 60.96-68.87 and 61.87-66.99%, respectively. Meanwhile, the intra- and inter-day precisions (expressed as relative standard deviation) were 1.02-12.95 and 1.71-5.50%, respectively. The method's detection limit (1 ng/g) was very low, thus enabling the detection of low residue levels. The applicability of the developed method was demonstrated with actual market samples and none of the tested analytes was detected in any of the samples.
[Mh] Termos MeSH primário: Aminopirina/análise
Antipirina/análise
Cromatografia Líquida
Ovos/análise
Análise de Alimentos/métodos
Leite/química
Músculos/química
Espectrometria de Massas em Tandem
[Mh] Termos MeSH secundário: Aminopirina/metabolismo
Animais
Antipirina/metabolismo
Limite de Detecção
Estrutura Molecular
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
01704YP3MO (Aminopyrine); T3CHA1B51H (Antipyrine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151006
[St] Status:MEDLINE
[do] DOI:10.1002/jssc.201500920


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[PMID]:25594703
[Au] Autor:Schütte K; Seidensticker R; Milbradt O; Bornschein J; Kandulski A; Pech M; Kropf S; Ricke J; Malfertheiner P
[Ad] Endereço:Klinik für Gastroenterologie, Hepatologie & Infektiologie, Universitätsklinikum Magdeburg A. ö. R.
[Ti] Título:Assessment and monitoring of liver function by ¹³C-aminopyrine breath test after selective transarterial chemoembolisation of hepatocellular carcinoma.
[So] Source:Z Gastroenterol;53(1):21-7, 2015 Jan.
[Is] ISSN:1439-7803
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Liver function and tumor staging are essential parameters for selection of treatment modalities in patients with hepatocellular carcinoma (HCC). Transarterial chemoembolization (TACE) is associated with a risk of deterioration of liver function. In clinical routine hepatic function in patients with liver cirrhosis is assessed by the Child-Pugh-classification. Dynamic breath tests allow the assessment of the hepatic functional mass and have the potential to give more accurate information on hepatic function periinterventionally. PATIENTS AND METHODS: A prospective clinical study was performed in 13 patients receiving a total of 18 TACE sessions. (13)C-aminopyrine breath test was performed the day before TACE, 2 days and 30 days after TACE and correlated with standard laboratory work-up of the patients. RESULTS: Fourteen TACE sessions were performed in Child A liver cirrhosis, 4 in Child B cirrhosis. All patients presented with impaired aminopyrine metabolism at baseline. No significant changes in the (13)C aminopyrine breath test following TACE were observed. Two patients treated in Child A cirrhosis decompensated to Child B, one of them recovered. No further decompensation was observed in patients treated in Child B cirrhosis. DISCUSSION AND CONCLUSION: Liver function assessment with (13)C-aminopyrine breath test and Child-Pugh-classification following TACE was discordant in a large proportion of patients. Whether a quantification of mitochondrial liver function in patients planned to undergo locoregional treatment of HCC in liver cirrhosis is helpful in the prediction of postprocedural liver decompensation needs to be addressed in larger prospective clinical trials.
[Mh] Termos MeSH primário: Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/terapia
Quimioembolização Terapêutica/métodos
Testes de Função Hepática/métodos
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/terapia
[Mh] Termos MeSH secundário: Idoso
Aminopirina/farmacocinética
Testes Respiratórios/métodos
Radioisótopos de Carbono/farmacocinética
Carcinoma Hepatocelular/metabolismo
Sistema Enzimático do Citocromo P-450/metabolismo
Monitoramento de Medicamentos/métodos
Feminino
Seres Humanos
Neoplasias Hepáticas/metabolismo
Masculino
Estadiamento de Neoplasias
Prognóstico
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbon Radioisotopes); 01704YP3MO (Aminopyrine); 9035-51-2 (Cytochrome P-450 Enzyme System)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150117
[Lr] Data última revisão:
150117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150117
[St] Status:MEDLINE
[do] DOI:10.1055/s-0034-1385230



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