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[PMID]: | 28864378 |
[Au] Autor: | Shamardl HA; El-Ashmony SM; Kamel HF; Fatani SH |
[Ad] Endereço: | Department of Pharmacology (HAS), Faculty of Medicine, Fayoum University, Fayoum, Egypt; Department of Pharmacology & Clinical Pharmacy (SME), Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. Electronic address: hanan2remember@yahoo.com. |
[Ti] Título: | Potential Cardiovascular and Renal Protective Effects of Vitamin D and Coenzyme Q in l-NAME-Induced Hypertensive Rats. |
[So] Source: | Am J Med Sci;354(2):190-198, 2017 Aug. | [Is] ISSN: | 1538-2990 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | BACKGROUND: Hypertension is one of the primary modifiable risk factors for cardiovascular disease. Adequate vitamin D (vit D) levels have been shown to reduce vascular smooth muscle contraction and to increase arterial compliance, which may be beneficial in hypertension. Further, coenzyme Q10 (COQ10) through its action to lower oxidative stress has been reported to have beneficial effects on hypertension and heart failure. This study examined the possible cardiac and renal protective effects of vit D and COQ10 both separately and in combination with an angiotensin II receptor blocker, valsartan (vals) in l-NAME hypertensive rats. MATERIALS AND METHODS: Hypertension was induced in rats by l-NAME administration. Following induction of hypertension, the rats were assigned into the following 6 subgroups: an l-NAME alone group and treated groups receiving the following drugs intraperitoneally for 6 weeks; vals, vit D, COQ10 and combination of vals with either vit D or COQ10. A group of normotensive rats were used as negative controls. At the end of the treatment period, blood pressure, serum creatinine, blood urea nitrogen, lipids and serum, cardiac and renal parameters of oxidative stress were measured. RESULTS: Compared to the l-NAME only group, all treatments lowered systolic, diastolic, mean arterial pressure, total cholesterol, low-density lipoprotein cholesterol, and creatinine levels as well as TNF-α and malondialdehyde. Further, the agents increased serum, cardiac and renal total antioxidant capacity. Interestingly, the combination of agents had further effects on all the parameters compared to treatment with each single agent. CONCLUSIONS: The study suggests that the additive protective effects of vit D and COQ10 when used alone or concurrent with vals treatment in hypertensive rats may be due to their effects as antioxidants, anticytokines and blood pressure conservers. |
[Mh] Termos MeSH primário: |
Hipertensão/tratamento farmacológico Ubiquinona/análogos & derivados Valsartana/farmacologia Vitamina D/farmacologia
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[Mh] Termos MeSH secundário: |
Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia Animais Doenças Cardiovasculares/tratamento farmacológico Hipertensão/induzido quimicamente Nefropatias/tratamento farmacológico NG-Nitroarginina Metil Éster/toxicidade Ratos Ratos Wistar Ubiquinona/farmacologia Ubiquinona/uso terapêutico Vitamina D/uso terapêutico Vitaminas/farmacologia
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Angiotensin II Type 1 Receptor Blockers); 0 (Vitamins); 1339-63-5 (Ubiquinone); 1406-16-2 (Vitamin D); 80M03YXJ7I (Valsartan); EJ27X76M46 (coenzyme Q10); V55S2QJN2X (NG-Nitroarginine Methyl Ester) |
[Em] Mês de entrada: | 1709 |
[Cu] Atualização por classe: | 170908 |
[Lr] Data última revisão:
| 170908 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 170903 |
[St] Status: | MEDLINE |
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