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[PMID]:24328056
[Au] Autor:Hernández-Gil J; Ferrer S; Castiñeiras A; Liu-González M; Lloret F; Ribes A; Coga L; Bernecker A; Mareque-Rivas JC
[Ad] Endereço:Departament de Química Inorgànica, Universitat de València , Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain.
[Ti] Título:Two novel ternary dicopper(II) µ-guanazole complexes with aromatic amines strongly activated by quantum dots for DNA cleavage.
[So] Source:Inorg Chem;53(1):578-93, 2014 Jan 06.
[Is] ISSN:1520-510X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Two novel (µ-guanazole)-bridged binuclear copper(II) complexes with 1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy), [Cu2(µ-N2,N4-Hdatrz)(phen)2(H2O)(NO3)4] (1) and [Cu2(µ-N1,N2-datrz)2(µ-OH2)(bipy)2](ClO4)2 (2) (Hdatrz = 3,5-diamino-1,2,4-triazole = guanazole), have been prepared and characterized by X-ray diffraction, spectroscopy, and susceptibility measurements. Compounds 1 and 2 differ in the aromatic amine, which acts as a coligand, and in the Cu···Cu'-bridging system. Compound 1, which contains two mono-bridged copper ions, represents the first example of a discrete Cu-(NCN-trz)-Cu' complex. Compound 2, with two triply bridged copper ions, is one of the few compounds featuring a Cu-[(NN-trz)2 + (O-aquo)]-Cu' unit. Both compounds display antiferromagnetic coupling but of different magnitude: J (µ2,4-triazole) = -52 cm(-1) for 1 and J (µ1,2-triazolate) = -115 cm(-1) for 2. The DNA binding and cleavage properties of the two compounds have been investigated. Fluorescence, viscosimetry, and thermal denaturation studies reveal that both complexes have high affinity for DNA (1 > 2) and that only 1 acts as an intercalator. In the presence of a reducing agent like 3-mercaptopropionic acid, 1 produces significant oxidative DNA cleavage, whereas 2 is inactive. However, in the presence of very small quantities of micelles filled with core-shell CdSe-ZnS quantum dots (15 nM), 1 and 2 are considerably more active and become highly efficient nucleases as a result of the different possible mechanisms for promoting cooperative catalysis (metal-metal, metal-hydrogen bonding, metal-intercalation, and metal-nanoparticle). Electrophoresis DNA-cleavage inhibition experiments, X-ray photoelectron spectroscopy studies, and fluorescence ethidium bromide displacement assays reveal that in these novel nucleases the QDs act as redox-active protein-like nanoparticle structures that bind to the DNA and deliver electrons to the copper(II) centers for the generation of Cu(I) and reactive oxygen species.
[Mh] Termos MeSH primário: Aminas/química
Cobre/química
DNA/efeitos dos fármacos
Guanazol/química
Compostos Organometálicos/farmacologia
Pontos Quânticos
[Mh] Termos MeSH secundário: Compostos de Cádmio/química
Cristalografia por Raios X
DNA/química
Clivagem do DNA
Modelos Moleculares
Estrutura Molecular
Compostos Organometálicos/síntese química
Compostos Organometálicos/química
Compostos de Selênio/química
Sulfetos/química
Compostos de Zinco/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 0 (Cadmium Compounds); 0 (Organometallic Compounds); 0 (Selenium Compounds); 0 (Sulfides); 0 (Zinc Compounds); 789U1901C5 (Copper); 9007-49-2 (DNA); A7F646JC5C (cadmium selenide); I01TWM5267 (Guanazole); KPS085631O (zinc sulfide)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140106
[Lr] Data última revisão:
140106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131217
[St] Status:MEDLINE
[do] DOI:10.1021/ic4027249


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[PMID]:22925973
[Au] Autor:Guennoun L; Zaydoun S; El Jastimi J; Marakchi K; Komiha N; Kabbaj OK; El Hajji A; Guédira F
[Ad] Endereço:Laboratoire de Spectroscopie Infrarouge, Département de Chimie, Faculté des Sciences, Université Mohammed V-Agdal, Avenue Ibn Batouta, Rabat, Morocco. guennoun_loubna@yahoo.fr
[Ti] Título:Molecular structure and vibrational study of diprotonated guanazolium using DFT calculations and FT-IR and FT-Raman spectroscopies.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;97:975-85, 2012 Nov.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The purpose of this manuscript is to discuss our investigations of diprotonated guanazolium chloride using vibrational spectroscopy and quantum chemical methods. The solid phase FT-IR and FT-Raman spectra were recorded in the regions 4000-400cm(-1) and 3600-50cm(-1) respectively, and the band assignments were supported by deuteration effects. Different sites of diprotonation have been theoretically examined at the B3LYP/6-31G level. The results of energy calculations show that the diprotonation process occurs with the two pyridine-like nitrogen N2 and N4 of the triazole ring. The molecular structure, harmonic vibrational wave numbers, infrared intensities and Raman activities were calculated for this form by DFT/B3LYP methods, using a 6-31G basis set. Both the optimized geometries and the theoretical and experimental spectra for diprotonated guanazolium under a stable form are compared with theoretical and experimental data of the neutral molecule reported in our previous work. This comparison reveals that the diprotonation occurs on the triazolic nucleus, and provide information about the hydrogen bonding in the crystal. The scaled vibrational wave number values of the diprotonated form are in close agreement with the experimental data. The normal vibrations were characterized in terms of potential energy distribution (PED) using the VEDA 4 program.
[Mh] Termos MeSH primário: Guanazol/química
Modelos Moleculares
Teoria Quântica
Análise Espectral Raman
Triazóis/química
Vibração
[Mh] Termos MeSH secundário: Conformação Molecular
Espectroscopia de Infravermelho com Transformada de Fourier
Termodinâmica
Titulometria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,5-diamino-1,2,4-triazole); 0 (Triazoles); I01TWM5267 (Guanazole)
[Em] Mês de entrada:1302
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120829
[St] Status:MEDLINE


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[PMID]:21112810
[Au] Autor:Guennoun L; El jastimi J; Guédira F; Marakchi K; Kabbaj OK; El Hajji A; Zaydoun S
[Ad] Endereço:Laboratoire de Spectroscopie Infrarouge, Département de Chimie, Faculté des Sciences, Avenue Ibn Batouta, Rabat, Morocco. guennoun_loubna@yahoo.fr
[Ti] Título:Molecular geometry and vibrational studies of 3,5-diamino-1,2,4-triazole using quantum chemical calculations and FT-IR and FT-Raman spectroscopies.
[So] Source:Spectrochim Acta A Mol Biomol Spectrosc;78(1):347-53, 2011 Jan.
[Is] ISSN:1873-3557
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The 3,5-diamino-1,2,4-triazole (guanazole) was investigated by vibrational spectroscopy and quantum methods. The solid phase FT-IR and FT-Raman spectra were recorded in the region 4000-400 cm(-1) and 3600-50 cm(-1) respectively, and the band assignments were supported by deuteration effects. The results of energy calculations have shown that the most stable form is 1H-3,5-diamino-1,2,4-triazole under C1 symmetry. For this form, the molecular structure, harmonic vibrational wave numbers, infrared intensities and Raman activities were calculated by the ab initio/HF and DFT/B3LYP methods using 6-31G* basis set. The calculated geometrical parameters of the guanazole molecule using B3LYP methodology are in good agreement with the previously reported X-ray data, and the scaled vibrational wave number values are in good agreement with the experimental data. The normal vibrations were characterized in terms of potential energy distribution (PEDs) using VEDA 4 program.
[Mh] Termos MeSH primário: Modelos Químicos
Conformação Molecular
Teoria Quântica
Análise Espectral Raman
Triazóis/química
Vibração
[Mh] Termos MeSH secundário: Guanazol/química
Espectroscopia de Infravermelho com Transformada de Fourier
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3,5-diamino-1,2,4-triazole); 0 (Triazoles); I01TWM5267 (Guanazole)
[Em] Mês de entrada:1104
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101130
[St] Status:MEDLINE
[do] DOI:10.1016/j.saa.2010.10.019


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[PMID]:9111921
[Au] Autor:Trevors JT
[Ad] Endereço:Department of Environmental Biology, University of Guelph, Ontario, Canada. jtrevors@uoguelph.ca
[Ti] Título:Evolution of bacterial genomes.
[So] Source:Antonie Van Leeuwenhoek;71(3):265-70, 1997 Mar.
[Is] ISSN:0003-6072
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:This review examines evolution of bacterial genomes with an emphasis on RNA based life, the transition to functional DNA and small evolving genomes (possible plasmids) that led to larger, functional bacterial genomes.
[Mh] Termos MeSH primário: Bactérias/genética
Bactérias/metabolismo
Evolução Biológica
Genoma Bacteriano
RNA Bacteriano/genética
RNA Bacteriano/metabolismo
[Mh] Termos MeSH secundário: Proteínas de Bactérias/metabolismo
DNA Bacteriano/genética
DNA Bacteriano/metabolismo
Guanazol/química
Estrutura Molecular
Peptídeos/metabolismo
Plasmídeos
Vírus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Bacterial Proteins); 0 (DNA, Bacterial); 0 (Peptides); 0 (RNA, Bacterial); I01TWM5267 (Guanazole)
[Em] Mês de entrada:9706
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:970301
[St] Status:MEDLINE


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[PMID]:11539446
[Au] Autor:Kolb VM; Dworkin JP; Miller SL
[Ad] Endereço:Department of Chemistry, University of California, San Diego, La Jolla 92093-0317, USA.
[Ti] Título:Alternative bases in the RNA world: the prebiotic synthesis of urazole and its ribosides.
[So] Source:J Mol Evol;38:549-57, 1994.
[Is] ISSN:0022-2844
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Urazole is a five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts spontaneoulsy with ribose (and other aldoses) to give a mixture of four ribosides: alpha and beta pyranosides and furanosides. This reaction occurs in aqueous solution at mild temperatures. Thermodynamic and kinetic parameters for the reaction of urazole with ribose were determined. In contrast, uracil is completely unreactive with ribose under these conditions. Urazole's unusual reactivity is ascribed to the hydrazine portion of the molecule. Urazole can be synthesized from biuret and hydrazine under prebiotic conditions. The prebiotic synthesis of guanazole, which is isosteric in part to diaminopyrimidine and cytosine, is accomplished from dicyandiamide and hydrazine. Kinetic parameters for both prebiotic reactions were measured. Urazole and guanazole are transparent in the UV, which would be a favorable property in the absence of an ozone layer on the early Earth. Urazole makes hydrogen bonds with adenine in DMSO similar to those of uracil, as established by H NMR. All of these properties make urazole an attractive potential precursor to uracil and guanazole a potential precursor to cytosine in the RNA or pre-RNA world.
[Mh] Termos MeSH primário: Evolução Química
Guanazol/síntese química
RNA/química
Ribose/química
[Mh] Termos MeSH secundário: Citosina/química
Evolução Molecular
Guanazol/química
Hidrazinas/química
Espectroscopia de Ressonância Magnética
Nucleosídeos/síntese química
Uracila/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Hydrazines); 0 (Nucleosides); 56HH86ZVCT (Uracil); 63231-63-0 (RNA); 681HV46001 (Ribose); 8J337D1HZY (Cytosine); I01TWM5267 (Guanazole)
[Em] Mês de entrada:9708
[Cu] Atualização por classe:170714
[Lr] Data última revisão:
170714
[Sb] Subgrupo de revista:S
[Da] Data de entrada para processamento:940101
[St] Status:MEDLINE


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[PMID]:1860812
[Au] Autor:Tipples G; McClarty G
[Ad] Endereço:Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
[Ti] Título:Isolation and initial characterization of a series of Chlamydia trachomatis isolates selected for hydroxyurea resistance by a stepwise procedure.
[So] Source:J Bacteriol;173(16):4932-40, 1991 Aug.
[Is] ISSN:0021-9193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chlamydiae are obligate intracellular bacteria that are dependent on eukaryotic host cells for ribonucleoside triphosphates but not deoxyribonucleotide triphosphates. Ribonucleotide reductase is the only enzyme known to catalyze the direct conversion of a ribonucleotide to a deoxyribonucleotide. Hydroxyurea inhibits ribonucleotide reductase by inactivating the tyrosine free radical present in the small subunit of the enzyme. In this report, we show that Chlamydia trachomatis growth is inhibited by hydroxyurea in both wild-type mouse L cells and hydroxyurea-resistant mouse L cells. Hydroxyurea was used as a selective agent in culture to isolate, by a stepwise procedure, a series of C. trachomatis isolates with increasing levels of resistance to the cytotoxic effects of the drug. One of the drug-resistant C. trachomatis isolates (L2HR-10.0) was studied in more detail. L2HR-10.0 retained its drug resistance phenotype even after passage in the absence of hydroxyurea for 10 growth cycles. In addition, L2HR-10.0 was cross resistant to guanazole, another inhibitor of ribonucleotide reductase. Results obtained from hydroxyurea inhibition studies using various host cell-parasite combinations indicated that inhibition of host cell and C. trachomatis DNA synthesis by hydroxyurea can occur but need not occur simultaneously. Crude extract prepared from highly purified C. trachomatis reticulate bodies was capable of reducing CDP to dCDP. The CDP reductase activity was not inhibited by monoclonal antibodies to the large and small subunits of mammalian ribonucleotide reductase, suggesting that the activity is chlamydia specific. The CDP reductase activity was inhibited by hydroxyurea. Crude extract prepared from drug-resistant L2HR-10.0 reticulate bodies contained an elevation in ribonucleotide reductase activity. In total, our results indicate that C. trachomatis obtains the precursors for DNA synthesis as ribonucleotides with subsequent conversion to deoxyribonucleotides catalyzed by a chlamydia-specific ribonucleotide reductase.
[Mh] Termos MeSH primário: Chlamydia trachomatis/efeitos dos fármacos
Hidroxiureia/farmacologia
[Mh] Termos MeSH secundário: Adenina/metabolismo
Animais
Chlamydia trachomatis/genética
Chlamydia trachomatis/isolamento & purificação
Chlamydia trachomatis/metabolismo
Cistina Difosfato/metabolismo
DNA Bacteriano/biossíntese
Resistência Microbiana a Medicamentos
Guanazol/farmacologia
Células L (Linhagem Celular)
Mutação
Ribonucleotídeo Redutases/antagonistas & inibidores
Ribonucleotídeo Redutases/metabolismo
Seleção Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Bacterial); 63-38-7 (Cytidine Diphosphate); EC 1.17.4.- (Ribonucleotide Reductases); I01TWM5267 (Guanazole); JAC85A2161 (Adenine); X6Q56QN5QC (Hydroxyurea)
[Em] Mês de entrada:9109
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:910801
[St] Status:MEDLINE


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[PMID]:2292052
[Au] Autor:Wani MA; Snapka RM
[Ad] Endereço:Department of Radiology, Ohio State University 43210.
[Ti] Título:Drug-induced loss of unstably amplified genes.
[So] Source:Cancer Invest;8(6):587-93, 1990.
[Is] ISSN:0735-7907
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Methotrexate-resistant R500 cells slowly lose amplified dihydrofolate reductase (dhrf) genes with biphasic kinetics when grown in the absence of methotrexate. Both phases of gene loss were markedly accelerated by subcytotoxic drug treatments. R500 cells were passed in low concentrations of cytotoxic drugs (inhibitors of ribonucleotide reductase, type I and type II topoisomerases, and polyamine synthesis). At each passage, relative dhfr gene copy number was determined by slot blot analysis. All of these drugs were able to induce rapid loss of dhfr gene dosage in the R500 cell population. The ability of these treatments to cause the rapid emergence of a cell population with substantially reduced dhfr gene dosage indicates that either the amplified genes or those cells with the highest levels of gene amplification are selectively targeted by low-level cytotoxic stress. The complex kinetics of amplified gene loss are suggestive of differential targeting of resistant cell subpopulations.
[Mh] Termos MeSH primário: Amplificação de Genes/efeitos dos fármacos
Metotrexato/farmacologia
Tetra-Hidrofolato Desidrogenase/genética
[Mh] Termos MeSH secundário: Camptotecina/farmacologia
Relação Dose-Resposta a Droga
Resistência a Medicamentos
Eflornitina/farmacologia
Guanazol/farmacologia
Hidroxiureia/farmacologia
Proflavina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Gs] Símbolo de gene:dhfr
[Nm] Nome de substância:
CY3RNB3K4T (Proflavine); EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase); I01TWM5267 (Guanazole); X6Q56QN5QC (Hydroxyurea); XT3Z54Z28A (Camptothecin); YL5FZ2Y5U1 (Methotrexate); ZQN1G5V6SR (Eflornithine)
[Em] Mês de entrada:9104
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900101
[St] Status:MEDLINE


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[PMID]:2117252
[Au] Autor:Suter W; Romagna F
[Ad] Endereço:Toxicology Department, Sandoz Pharma Ltd., Basle, Switzerland.
[Ti] Título:DNA repair induced by various mutagens in rat hepatocyte primary cultures measured in the presence of hydroxyurea, guanazole or aphidicolin.
[So] Source:Mutat Res;231(2):251-64, 1990 Aug.
[Is] ISSN:0027-5107
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication which could be used instead of hydroxyurea to measure DNA repair synthesis in rat hepatocyte primary cultures by liquid scintillation counting. The genotoxicity of these 3 chemicals was studied using the Salmonella/liver homogenate assay and the autoradiographic UDS test in hepatocytes. Hydroxyurea was positive in both of these assays. Guanazole and aphidicolin did not induce DNA repair in hepatocytes. Aphidicolin was not mutagenic for Salmonella typhimurium, whereas guanazole increased the revertant numbers of strain TA102 slightly. The incorporation of [3H]thymidine was measured by liquid scintillation to determine DNA repair induced by 2-acetylaminofluorene (2-AAF), aflatoxin B1, benzo[a]pyrene, cyclophosphamide, H2O2, 6-hydroxydopamine, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), methylnitrosourea (MNU), 4-nitroquinoline-N-oxide and UV irradiation in the presence of either 10 mM hydroxyurea, 15 mM guanazole or 0.015 mM aphidicolin. Aphidicolin had an inhibitory effect on DNA repair. Except for the 3 chemicals mentioned below, the sensitivity of the DNA repair measurement was the same, no matter whether hydroxyurea or guanazole was used to inhibit replicative DNA synthesis. In the presence of hydroxyurea, DNA repair synthesis was found at lower concentrations in the case of aflatoxin B1, due to differences in the solvent control values, and in the case of H2O2, possibly due to a synergistic effect between hydroxyurea and H2O2. Guanazole allowed the detection of DNA repair induced by MNNG at lower concentrations, probably because of an antagonistic effect between hydroxyurea and MNNG. Based on these results, it was concluded that guanazole, but not aphidicolin, could be used instead of hydroxyurea to measure DNA repair synthesis by liquid scintillation in rat hepatocyte primary cultures. Although guanazole does not completely fulfill the criteria for an ideal DNA replication inhibitor, it has the advantage of being less genotoxic than hydroxyurea, and also appears to have a smaller potential to falsify the results by interacting with the test compounds.
[Mh] Termos MeSH primário: Reparo do DNA/efeitos dos fármacos
Diterpenos/farmacologia
Guanazol/farmacologia
Hidroxiureia/farmacologia
Mutagênicos
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Afidicolina
Células Cultivadas
Dano ao DNA
Fígado/citologia
Masculino
Testes de Mutagenicidade
Ratos
Ratos Endogâmicos
Salmonella typhimurium/efeitos dos fármacos
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Diterpenes); 0 (Mutagens); 0 (Triazoles); 38966-21-1 (Aphidicolin); I01TWM5267 (Guanazole); X6Q56QN5QC (Hydroxyurea)
[Em] Mês de entrada:9009
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:900801
[St] Status:MEDLINE


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[PMID]:3719585
[Au] Autor:Krauss S; Broder LE; Birch R
[Ti] Título:Guanazole in the treatment of advanced bronchogenic carcinoma: a pilot study of the Southeastern Cancer Study Group.
[So] Source:Cancer Treat Rep;70(7):913-4, 1986 Jul.
[Is] ISSN:0361-5960
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Carcinoma Broncogênico/tratamento farmacológico
Guanazol/uso terapêutico
Neoplasias Pulmonares/tratamento farmacológico
Triazóis/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Broncogênico/mortalidade
Feminino
Guanazol/efeitos adversos
Seres Humanos
Neoplasias Pulmonares/mortalidade
Masculino
Meia-Idade
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, P.H.S.
[Nm] Nome de substância:
0 (Triazoles); I01TWM5267 (Guanazole)
[Em] Mês de entrada:8608
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:860701
[St] Status:MEDLINE


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[PMID]:3898152
[Au] Autor:Moore EC; Hurlbert RB
[Ti] Título:The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY).
[So] Source:Pharmacol Ther;27(2):167-96, 1985.
[Is] ISSN:0163-7258
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Guanazol/farmacologia
Hidroxiureia/farmacologia
Pirazóis/farmacologia
Ribonucleosídeo Difosfato Redutase/antagonistas & inibidores
Ribonucleotídeo Redutases/antagonistas & inibidores
Triazóis/farmacologia
[Mh] Termos MeSH secundário: Anormalidades Induzidas por Medicamentos
Animais
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Ciclo Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
DNA/biossíntese
Reparo do DNA
Replicação do DNA
Resistência a Medicamentos
Histonas/biossíntese
Seres Humanos
Hidroxiureia/uso terapêutico
Hidroxiureia/toxicidade
Técnicas In Vitro
Mutagênicos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Histones); 0 (Mutagens); 0 (Pyrazoles); 0 (Triazoles); 9007-49-2 (DNA); EC 1.17.4.- (Ribonucleotide Reductases); EC 1.17.4.1 (Ribonucleoside Diphosphate Reductase); I01TWM5267 (Guanazole); MX6Z942BKY (2,3-dihydro-1H-imidazo(1,2-b)pyrazole); X6Q56QN5QC (Hydroxyurea)
[Em] Mês de entrada:8510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:850101
[St] Status:MEDLINE



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