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[PMID]:29384619
[Au] Autor:Zhao H; Wang YL; Peng JR; Zhang L; Qu Y; Chu BY; Dong ML; Tan LW; Qian ZY
[Ti] Título:Biodegradable Self-Assembled Micelles Based on MPEG-PTMC Copolymers: An Ideal Drug Delivery System for Vincristine.
[So] Source:J Biomed Nanotechnol;13(4):427-36, 2017 Apr.
[Is] ISSN:1550-7033
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite advantageous properties, micelles using methoxy poly(ethylene glycol)-poly(trimethylene carbonate) (MPEGPTMC) have not been widely studied. In this work, we aim to develop a novel vehicle for vincristine (VCR) based on a MPEG-PTMC micelle system. MPEG-PTMC with a series of molecular weights were synthesized and screened for the appropriate range for forming stable VCR micelles. The prepared micelles were then characterized in vitro and in vivo . VCR micelles presented high stability and ideal sustained release profile. The passive targeting effect was also enhanced compared with liposomal VCR. These results provide critical data to give the first clues regarding novel VCR micelles which exhibit potential for clinical application.
[Mh] Termos MeSH primário: Implantes Absorvíveis
Dioxanos/química
Implantes de Medicamento/química
Nanocápsulas/química
Polietilenoglicóis/química
Vincristina/administração & dosagem
Vincristina/química
[Mh] Termos MeSH secundário: Cristalização/métodos
Difusão
Composição de Medicamentos/métodos
Implantes de Medicamento/administração & dosagem
Micelas
Nanocápsulas/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dioxanes); 0 (Drug Implants); 0 (Micelles); 0 (Nanocapsules); 0 (monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate)); 30IQX730WE (Polyethylene Glycols); 5J49Q6B70F (Vincristine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE


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[PMID]:28463833
[Au] Autor:Fujimura M; Joo JY; Kim JS; Hatta M; Yokoyama Y; Tominaga T
[Ad] Endereço:Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
[Ti] Título:Preventive Effect of Clazosentan against Cerebral Vasospasm after Clipping Surgery for Aneurysmal Subarachnoid Hemorrhage in Japanese and Korean Patients.
[So] Source:Cerebrovasc Dis;44(1-2):59-67, 2017.
[Is] ISSN:1421-9786
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clazosentan has been explored worldwide for the prophylaxis of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). In a dose-finding trial (CONSCIOUS-1) conducted in Israel, Europe, and North America, clazosentan (1, 5, and 15 mg/h) significantly reduced the incidence of cerebral vasospasm, but its efficacy in Japanese and Korean patients was unknown. We conducted a double-blind comparative study to evaluate the occurrence of cerebral vasospasm in Japanese and Korean patients with aSAH. METHODS: The aim of this multicenter, double-blind, randomized, placebo-controlled, dose-finding phase 2 clinical trial, was to evaluate the efficacy, pharmacokinetics, and safety of clazosentan (5 and 10 mg/h) against cerebral vasospasm after clipping surgery in Japanese and Korean patients with aSAH. Patients aged between 20 and 75 years were administered the study drug within 56 h after the aneurysm rupture and up to day 14 post-aSAH. The incidence of vasospasm, defined as an inner artery diameter reduction of major intracranial arteries ≥34% based on catheter angiography, was compared between each treatment group. Cerebral infarction due to vasospasm at 6 weeks and patients' outcome at 3 months was also compared. RESULTS: Among 181 enrolled patients, 158 completed the study and were analyzed. The incidence of vasospasm up to day 14 after aSAH onset was 80.0% in the placebo group (95% CI 67.0-89.6), 38.5% in the 5 mg/h clazosentan group (95% CI 25.3-53.0), and 35.3% in the 10 mg/h clazosentan group (95% CI 22.4-49.9), indicating that the incidence of vasospasm was significantly reduced by clazosentan treatment (placebo vs. 5 mg/h clazosentan, p < 0.0001; placebo vs. 10 mg/h clazosentan, p < 0.0001). The occurrence of cerebral infarction due to vasospasm was 20.8% in the placebo group (95% CI 10.8-34.1), 3.8% in the 5 mg/h clazosentan group (95% CI 0.5-13.2), and 4.2% in the 10 mg/h clazosentan group (95% CI 0.5-14.3), indicating that clazosentan significantly reduced the occurrence of cerebral infarctions caused by vasospasm (placebo vs. 5 mg/h clazosentan, p = 0.0151; placebo vs. 10 mg/h clazosentan, p = 0.0165). The overall incidence of all-cause death and/or vasospasm-related morbidity/mortality was significantly reduced in the 10 mg/h clazosentan group compared with the placebo group (p = 0.0003). CONCLUSION: These results suggest that clazosentan prevents cerebral vasospasm and subsequent cerebral infarction, and could thereby improve outcomes after performing a clipping surgery for aSAH in Japanese and Korean patients.
[Mh] Termos MeSH primário: Infarto Cerebral/prevenção & controle
Dioxanos/uso terapêutico
Antagonistas do Receptor de Endotelina A/uso terapêutico
Procedimentos Neurocirúrgicos/efeitos adversos
Piridinas/uso terapêutico
Pirimidinas/uso terapêutico
Hemorragia Subaracnóidea/cirurgia
Sulfonamidas/uso terapêutico
Tetrazóis/uso terapêutico
Vasodilatadores/uso terapêutico
Vasoespasmo Intracraniano/prevenção & controle
[Mh] Termos MeSH secundário: Adulto
Idoso
Angiografia Digital
Angiografia Cerebral/métodos
Infarto Cerebral/diagnóstico por imagem
Infarto Cerebral/etiologia
Infarto Cerebral/fisiopatologia
Dioxanos/efeitos adversos
Dioxanos/farmacocinética
Método Duplo-Cego
Antagonistas do Receptor de Endotelina A/efeitos adversos
Antagonistas do Receptor de Endotelina A/farmacocinética
Feminino
Seres Humanos
Japão
Masculino
Meia-Idade
Piridinas/efeitos adversos
Piridinas/farmacocinética
Pirimidinas/efeitos adversos
Pirimidinas/farmacocinética
República da Coreia
Hemorragia Subaracnóidea/diagnóstico por imagem
Hemorragia Subaracnóidea/fisiopatologia
Sulfonamidas/efeitos adversos
Sulfonamidas/farmacocinética
Tetrazóis/efeitos adversos
Tetrazóis/farmacocinética
Fatores de Tempo
Resultado do Tratamento
Vasodilatadores/efeitos adversos
Vasodilatadores/farmacocinética
Vasoespasmo Intracraniano/diagnóstico por imagem
Vasoespasmo Intracraniano/etiologia
Vasoespasmo Intracraniano/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dioxanes); 0 (Endothelin A Receptor Antagonists); 0 (Pyridines); 0 (Pyrimidines); 0 (Sulfonamides); 0 (Tetrazoles); 0 (Vasodilator Agents); 3DRR0X4728 (clazosentan)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1159/000475824


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[PMID]:28796687
[Au] Autor:Buresch AM; Van Arsdale A; Ferzli M; Sahasrabudhe N; Sun M; Bernstein J; Bernstein PS; Ngai IM; Garry DJ
[Ad] Endereço:Department of Obstetrics & Gynecology and Women's Health and the Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, New York.
[Ti] Título:Comparison of Subcuticular Suture Type for Skin Closure After Cesarean Delivery: A Randomized Controlled Trial.
[So] Source:Obstet Gynecol;130(3):521-526, 2017 Sep.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare the rate of wound complications among women who underwent cesarean delivery through a Pfannenstiel skin incision followed by subcuticular closure with either poliglecaprone 25 suture or polyglactin 910 suture. METHODS: Patients undergoing nonemergent cesarean delivery at or beyond 37 weeks of gestation were randomized to undergo subcuticular skin closure with either poliglecaprone 25 or polyglactin 910. The primary outcome was a wound composite outcome of one or more of the following: surgical site infection, wound separation, hematoma, or seroma within the first 30 days postpartum. To detect a reduction in the primary outcome rate from 12% to 4%, with a power of 0.90 and a two-tailed α of 0.05, 237 women per study group were required. Analysis was performed according to the intent-to-treat principle. RESULTS: From May 28, 2015, to August 5, 2016, 275 women were randomized to poliglecaprone 25 and 275 to polyglactin 910, of whom 520 (95%) were included in the final analysis: 263 in the poliglecaprone 25 group [of whom 231 (88%) actually underwent poliglecaprone 25 closure) and 257 in the polyglactin 910 group [of whom 209 (81%) actually underwent polyglactin 910 closure]. The groups were similar in demographic characteristics, medical comorbidities, and perioperative characteristics. Poliglecaprone 25 was associated with a significantly decreased rate of overall wound complications when compared with polyglactin 910, 8.8% compared with 14.4% (relative risk 0.61, 95% CI 0.37-0.99; P=.04). CONCLUSION: Closure of the skin after cesarean delivery with poliglecaprone 25 suture decreases the rate of wound complications compared with polyglactin 910 suture. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02459093.
[Mh] Termos MeSH primário: Cesárea
Técnicas de Sutura
Suturas
[Mh] Termos MeSH secundário: Adulto
Procedimentos Cirúrgicos Dermatológicos
Dioxanos/administração & dosagem
Feminino
Seres Humanos
Poliésteres/administração & dosagem
Poliglactina 910/administração & dosagem
Gravidez
Estudos Prospectivos
Deiscência da Ferida Operatória
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dioxanes); 0 (Polyesters); 34346-01-5 (Polyglactin 910); 41706-81-4 (glycolide E-caprolactone copolymer)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002200


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[PMID]:28779508
[Au] Autor:Schäfer PM; Fuchs M; Ohligschläger A; Rittinghaus R; McKeown P; Akin E; Schmidt M; Hoffmann A; Liauw MA; Jones MD; Herres-Pawlis S
[Ad] Endereço:Institut für Anorganische Chemie, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
[Ti] Título:Highly Active N,O Zinc Guanidine Catalysts for the Ring-Opening Polymerization of Lactide.
[So] Source:ChemSusChem;10(18):3547-3556, 2017 Sep 22.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:New zinc guanidine complexes with N,O donor functionalities were prepared, characterized by X-Ray crystallography, and examined for their catalytic activity in the solvent-free ring-opening polymerization (ROP) of technical-grade rac-lactide at 150 °C. All complexes showed a high activity. The fastest complex [ZnCl (DMEGasme)] (C1) produced colorless poly(lactide) (PLA) after 90 min with a conversion of 52 % and high molar masses (M =69 100, polydispersity=1.4). The complexes were tested with different monomer-to-initiator ratios to determine the rate constant k . Furthermore, a polymerization with the most active complex C1 was monitored by in situ Raman spectroscopy. Overall, conversion of up to 90 % can be obtained. End-group analysis was performed to clarify the mechanism. All four complexes combine robustness against impurities in the lactide with high polymerization rates, and they represent the fastest robust lactide ROP catalysts to date, opening new avenues to a sustainable ROP catalyst family for industrial use.
[Mh] Termos MeSH primário: Dioxanos/química
Nitrogênio/química
Oxigênio/química
Polimerização
Zinco/química
[Mh] Termos MeSH secundário: Modelos Moleculares
Conformação Molecular
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 95-96-5 (dilactide); J41CSQ7QDS (Zinc); N762921K75 (Nitrogen); S88TT14065 (Oxygen)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170806
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201701237


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[PMID]:28727369
[Au] Autor:Kaygisiz O; Çelen S; Vuruskan BA; Vuruskan H
[Ad] Endereço:Department of Urology, Uludag University, Faculty of Medicine, Bursa, Turkey.
[Ti] Título:Comparison of two different suture techniques in laparoscopic partial nephrectomy.
[So] Source:Int Braz J Urol;43(5):863-870, 2017 Sep-Oct.
[Is] ISSN:1677-6119
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To comparatively evaluate the traditional interrupted knot-tying and running suture renorrhaphy with Monocryl® in laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS: A retrospective analysis of 62 consecutive patients undergoing LPN using traditional interrupted knot-tying suture renorrhaphy (Group 1; n=31) or running suture technique renorrhaphy with 2-0 monofilament polyglecaprone (Monocryl®, Ethicon) (Group 2; n=31) from December 2011 to October 2015 at the University. All patients underwent LPN performed by an experienced laparoscopic surgeon. The demographic, perioperative and postoperative parameters were compared between the groups, and the effect of both suture techniques on the warm ischemic time (WIT) and trifecta were evaluated. RESULTS: The running suture renorrhaphy with Monocryl® reduced WIT, estimated blood lost and length of hospitalization stay significantly without increasing postoperative complication rate during LPN in comparison with interrupted knot-tying suture. CONCLUSION: The renorrhaphy using the running suture with Monocryl® is an effective and safe technique with the advantage of shortening WIT even in more challenging and larger tumors during LPN.
[Mh] Termos MeSH primário: Dioxanos/uso terapêutico
Neoplasias Renais/cirurgia
Laparoscopia/métodos
Nefrectomia/métodos
Poliésteres/uso terapêutico
Técnicas de Sutura
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 0 (Polyesters); 41706-81-4 (glycolide E-caprolactone copolymer)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1590/S1677-5538.IBJU.2016.0550


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[PMID]:28624739
[Au] Autor:Ouyang D; Yan J; Qian L; Chen Y; Han L; Su A; Zhang W; Ni H; Chen M
[Ad] Endereço:Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Degradation of 1,4-dioxane by biochar supported nano magnetite particles activating persulfate.
[So] Source:Chemosphere;184:609-617, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nano magnetite biochar composite (nFe O /biochar) was synthesized and used to activate persulfate for the degradation of 1,4-dioxane. Analytical techniques using X-ray diffraction (XRD), fourier transform infrared analysis (FTIR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM) indicated that nFe O was spherical and successfully loaded onto the surface of biochar. The results of batch-scale experiments illustrated that the 1,4-dioxane degradation efficiency in aqueous phase was 98.0% after 120 min reaction with the composite mass ratio of 1:1 between nFe O and the pine needle biochar pyrolyzed at 400 °C (P400) under the initial neutral pH. An electron paramagnetic resonance (EPR) study, free radical quenching experiment and XPS analysis were undertaken to illustrate the mechanism of persulfate activation by nFe O /biochar. Under acidic and neutral conditions, the predominant free radical was SO whereas OH and SO predominated when the initial pH was 9.0. The XPS analysis indicated that Fe(II) and oxygenated functional groups activated persulfate. In addition, carbon-carbon double bonds would be transformed into ketone and quinone which could activate persulfate during the reaction.
[Mh] Termos MeSH primário: Carvão Vegetal/química
Dioxanos/química
Óxido Ferroso-Férrico/química
Nanopartículas/química
[Mh] Termos MeSH secundário: Radicais Livres/química
Microscopia Eletrônica de Varredura
Espectroscopia Fotoeletrônica
Sulfatos/química
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 0 (Free Radicals); 0 (Sulfates); 0 (biochar); 16291-96-6 (Charcoal); J8A3S10O7S (1,4-dioxane); XM0M87F357 (Ferrosoferric Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE


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[PMID]:28613397
[Au] Autor:Ohn N; Shin J; Kim SS; Kim JG
[Ad] Endereço:Department of Chemistry and Institute of Physical Science, Chonbuk National University, Jeon-Ju, Jeollabuk-do, 54869, Korea.
[Ti] Título:Mechanochemical Ring-Opening Polymerization of Lactide: Liquid-Assisted Grinding for the Green Synthesis of Poly(lactic acid) with High Molecular Weight.
[So] Source:ChemSusChem;10(18):3529-3533, 2017 Sep 22.
[Is] ISSN:1864-564X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Mechanochemical polymerization of lactide is carried out by using ball milling. Mechanical energy from collisions between the balls and the vessel efficiently promotes an organic-base-mediated metal- and solvent-free solid-state polymerization. Investigation of the parameters of the ball-milling synthesis revealed that the degree of lactide ring-opening polymerization could be modulated by the ball-milling time, vibration frequency, mass of the ball media, and liquid-assisted grinding. Liquid-assisted grinding was found to be an especially important factor for achieving a high degree of mechanochemical polymerization. Although polymer-chain scission from the strong collision energy prevented mechanical-force-driven high-molecular-weight polymer synthesis, the addition of only a small amount of liquid enabled sufficient energy dissipation and poly(lactic acid) was thereby obtained with a molecular weight of over 1×10  g mol .
[Mh] Termos MeSH primário: Dioxanos/química
Química Verde
Fenômenos Mecânicos
Poliésteres/química
Poliésteres/síntese química
Polimerização
[Mh] Termos MeSH secundário: Técnicas de Química Sintética
Peso Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 0 (Polyesters); 459TN2L5F5 (poly(lactide)); 95-96-5 (dilactide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.1002/cssc.201700873


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[PMID]:28609709
[Au] Autor:Del Bello F; Bonifazi A; Giorgioni G; Petrelli R; Quaglia W; Altomare A; Falcicchio A; Matucci R; Vistoli G; Piergentili A
[Ad] Endereço:Scuola di Scienze del Farmaco e dei Prodotti della Salute, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy.
[Ti] Título:Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.
[So] Source:Eur J Med Chem;137:327-337, 2017 Sep 08.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:To obtain novel muscarinic acetylcholine receptor (mAChR) antagonists, the enantiomers of the hybrid compounds 3-5, in which the quinuclidin-3-yloxy fragment of solifenacin and the 6,6-diphenyl-1,4-dioxane-2-yl moiety of 2 linked by an ester or ether spacer were embedded in the same chemical entity, were prepared and evaluated for their affinity at the five mAChR subtypes (M -M ). Stereochemistry and the nature of the linker between the quinuclidine moiety and the 1,4-dioxane nucleus play an important role on the affinities of the compounds. The presence of an ether bridge confers higher affinities for all mAChR subtypes to the ligand. Interestingly, the ether enantiomer (R,S)-5 shows the highest affinity at all mAChR subtypes with pK values similar to that of solifenacin at M and higher at the other subtypes. Unlike solifenacin, it shows a preference for M mAChR subtype with respect to the other subtypes. This compound, lacking a permanent positive charge on the nitrogen atom, can be a useful tool for the pharmacological study of mAChRs in the central nervous system.
[Mh] Termos MeSH primário: Dioxanos/farmacologia
Antagonistas Muscarínicos/farmacologia
Quinuclidinas/farmacologia
Receptores Muscarínicos/metabolismo
[Mh] Termos MeSH secundário: Dioxanos/síntese química
Dioxanos/química
Relação Dose-Resposta a Droga
Seres Humanos
Ligantes
Estrutura Molecular
Antagonistas Muscarínicos/síntese química
Antagonistas Muscarínicos/química
Quinuclidinas/síntese química
Quinuclidinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 0 (Ligands); 0 (Muscarinic Antagonists); 0 (Quinuclidines); 0 (Receptors, Muscarinic); J8A3S10O7S (1,4-dioxane)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


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[PMID]:28478290
[Au] Autor:Feng Y; Lee PH; Wu D; Shih K
[Ad] Endereço:Department of Civil Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China. Electronic address: fengy@hku.hk.
[Ti] Título:Surface-bound sulfate radical-dominated degradation of 1,4-dioxane by alumina-supported palladium (Pd/Al O ) catalyzed peroxymonosulfate.
[So] Source:Water Res;120:12-21, 2017 Sep 01.
[Is] ISSN:1879-2448
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Sulfate radicals have been demonstrated as an alternative to hydroxyl radicals in advanced oxidation processes. Unfortunately, the efficient activation of peroxymonosulfate (PMS), one of the most commonly used oxidants for the generation of sulfate radicals, still relies heavily on cobalt-bearing materials that are potential carcinogens. Although copper-iron bimetallic materials are promising activators, stoichiometric amounts of metals are required to achieve satisfactory performance. In this study, we propose a real catalytic process that is capable of degrading extremely recalcitrant 1,4-dioxane using a combination of alumina-supported metallic palladium (Pd/Al O ) with PMS. The metal loading-normalized pseudo-first-order constant for 1,4-dioxane degradation with Pd/Al O was more than 16,800 times that with copper-iron bimetallic materials. Complementary to Fenton reagents, Pd/Al O -PMS had a wide effective pH range from 4.0 to 8.5. In the absence of a substrate, PMS underwent more rapid decomposition under all conditions investigated, which suggests that its activation did not likely proceed via the previously proposed non-radical mechanism. On the basis of the strong inhibitory effects of common scavengers, we instead propose that surface-bound sulfate radicals were probably the dominant active species. A near-100% conversion rate of PMS to radicals was achieved with the Pd/Al O catalyst.
[Mh] Termos MeSH primário: Peróxidos
Sulfatos
[Mh] Termos MeSH secundário: Óxido de Alumínio
Dioxanos
Oxirredução
Paládio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dioxanes); 0 (Peroxides); 0 (Sulfates); 0 (sulfate radical); 22047-43-4 (peroxymonosulfate); 5TWQ1V240M (Palladium); J8A3S10O7S (1,4-dioxane); LMI26O6933 (Aluminum Oxide)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170508
[St] Status:MEDLINE


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[PMID]:28408816
[Au] Autor:Li J; Deng J; Yuan J; Fu J; Li X; Tong A; Wang Y; Chen Y; Guo G
[Ad] Endereço:Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing.
[Ti] Título:Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury.
[So] Source:Int J Nanomedicine;12:2443-2456, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Spinal cord injury (SCI) commonly leads to lifelong disability due to the limited regenerative capacity of the adult central nervous system. Nanomicelles can be used as therapeutic systems to provide effective treatments for SCI. In this study, a novel triblock monomethyl poly(ethylene glycol)-poly(l-lactide)-poly(trimethylene carbonate) copolymer was successfully synthesized. Next, polymeric nanomicelles loaded with zonisamide (ZNS), a Food and Drug Administration-approved antiepileptic drug, were prepared and characterized. The ZNS-loaded micelles (ZNS-M) were further utilized for the treatment of SCI in vitro and in vivo. The obtained ZNS-M were ~50 nm in diameter with good solubility and dispersibility. Additionally, these controlled-release micelles showed significant antioxidative and neuron-protective effects in vitro. Finally, our results indicated that ZNS-M treatment could promote motor function recovery and could increase neuron and axon density in a hemisection SCI model. In summary, these results may provide an experimental basis for the use of ZNS-M as a clinically applicable therapeutic drug for the treatment of SCI in the future.
[Mh] Termos MeSH primário: Sistemas de Liberação de Medicamentos
Isoxazóis/uso terapêutico
Micelas
Nanopartículas/química
Polímeros/química
Traumatismos da Medula Espinal/tratamento farmacológico
[Mh] Termos MeSH secundário: Doença Aguda
Animais
Antioxidantes/farmacologia
Axônios/efeitos dos fármacos
Axônios/patologia
Barreira Hematoencefálica/efeitos dos fármacos
Barreira Hematoencefálica/patologia
Morte Celular/efeitos dos fármacos
Cromatografia em Gel
Dioxanos/síntese química
Dioxanos/química
Portadores de Fármacos
Liberação Controlada de Fármacos
Imagem por Ressonância Magnética
Camundongos
Poliésteres/síntese química
Poliésteres/química
Polietilenoglicóis/síntese química
Polietilenoglicóis/química
Espectroscopia de Prótons por Ressonância Magnética
Ratos Sprague-Dawley
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Dioxanes); 0 (Drug Carriers); 0 (Isoxazoles); 0 (Micelles); 0 (Polyesters); 0 (Polymers); 30IQX730WE (Polyethylene Glycols); 4316AQ174Q (trimethylene carbonate); 459384H98V (zonisamide); 459TN2L5F5 (poly(lactide)); 9004-74-4 (monomethoxypolyethylene glycol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S128705



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