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[PMID]:25923435
[Au] Autor:Tassonyi E; Pongrácz A; Nemes R; Asztalos L; Lengyel S; Fülesdi B
[Ad] Endereço:From the *Department of Anesthesiology and Intensive Care, University of Debrecen, Debrecen, Hungary; and †Department of Ecology, Hungarian Academy of Sciences, Centre for Ecological Research, Debrecen, Hungary.
[Ti] Título:Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial.
[So] Source:Anesth Analg;121(2):373-80, 2015 Aug.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pipecuronium is a steroidal neuromuscular blocking agent. Sugammadex, a relaxant binding γ-cyclodextrin derivative, reverses the effect of rocuronium, vecuronium, and pancuronium. We investigated whether sugammadex reverses moderate pipecuronium-induced neuromuscular blockade (NMB) and the doses required to achieve reversal. METHODS: This single-center, randomized, double-blind, 5-group parallel-arm study comprised 50 patients undergoing general anesthesia with propofol, sevoflurane, fentanyl, and pipecuronium. Neuromuscular monitoring was performed with acceleromyography (TOF-Watch SX) according to international standards. When the NMB recovered spontaneously to train-of-four count 2, patients randomly received 1.0, 2.0, 3.0, or 4.0 mg/kg of sugammadex or placebo. Recovery time from sugammadex injection to normalized train-of-four (TOF) ratio 0.9 was the primary outcome variable. The recovery time from the sugammadex injection to final T1 was the secondary end point. Postoperative neuromuscular functions were also assessed. RESULTS: Each patient who received sugammadex recovered to a normalized TOF ratio of 0.9 within 5.0 minutes (95% lower confidence interval for the lowest dose 70.1%; for all doses 90.8%) and 79% of these patients reached a normalized TOF ratio 0.9 within 2.0 minutes (95% lower confidence interval for the lowest dose 26.7%; for all doses 63.7%). T1 recovered several minutes after the TOF ratio. No residual postoperative NMB was observed. CONCLUSIONS: Sugammadex adequately and rapidly reverses pipecuronium-induced moderate NMB during sevoflurane anesthesia. Once the train-of-four count has spontaneously returned to 2 responses following pipecuronium administration, a dose of 2.0 mg/kg of sugammadex is sufficient to reverse the NMB.
[Mh] Termos MeSH primário: Anestesia Geral/métodos
Anestésicos Inalatórios
Antídotos/uso terapêutico
Éteres Metílicos
Bloqueio Neuromuscular/métodos
Bloqueadores Neuromusculares/uso terapêutico
Doenças da Junção Neuromuscular/prevenção & controle
Junção Neuromuscular/efeitos dos fármacos
Pipecurônio/uso terapêutico
gama-Ciclodextrinas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Idoso
Período de Recuperação da Anestesia
Método Duplo-Cego
Feminino
Seres Humanos
Hungria
Masculino
Meia-Idade
Bloqueio Neuromuscular/efeitos adversos
Bloqueadores Neuromusculares/efeitos adversos
Junção Neuromuscular/fisiopatologia
Doenças da Junção Neuromuscular/induzido quimicamente
Doenças da Junção Neuromuscular/diagnóstico
Doenças da Junção Neuromuscular/fisiopatologia
Monitoração Neuromuscular
Pipecurônio/efeitos adversos
Recuperação de Função Fisiológica
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Antidotes); 0 (Methyl Ethers); 0 (Neuromuscular Blocking Agents); 0 (gamma-Cyclodextrins); 1N3O74HM92 (Pipecuronium); 361LPM2T56 (Sugammadex); 38LVP0K73A (sevoflurane)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:151214
[Lr] Data última revisão:
151214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150430
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000000766


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[PMID]:23082652
[Ti] Título:[Residual neuromuscular blockade after muscle relaxants administration in neurosurgical patients].
[So] Source:Anesteziol Reanimatol;(4):73-6, 2012 Jul-Aug.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The paper analyzes the incidence of residual neuromuscular blockade (NMB) after pipecuronium and rocuronium administration in 124 neurosurgical patients. We analyzed neuromuscular conductance with TOF-Watch SX Residual NMB incidence after neuromuscular blocking agents administration in neurosurgical patients is 87.7%. Use of pipecuronium accompanied by a greater incidence and duration of residual NMB in comparison with rocuronium. Sugammadex administration is effective method of residual NMB reversal and can restore NMC in 3-5 minutes.
[Mh] Termos MeSH primário: Androstanóis/farmacologia
Bloqueio Neuromuscular/métodos
Pipecurônio/farmacologia
gama-Ciclodextrinas/farmacologia
[Mh] Termos MeSH secundário: Adulto
Lesões Encefálicas/fisiopatologia
Lesões Encefálicas/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Fármacos Neuromusculares não Despolarizantes
Procedimentos Neurocirúrgicos/métodos
Fatores de Tempo
Índices de Gravidade do Trauma
[Pt] Tipo de publicação:COMPARATIVE STUDY; ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Androstanols); 0 (Neuromuscular Nondepolarizing Agents); 0 (gamma-Cyclodextrins); 1N3O74HM92 (Pipecuronium); 361LPM2T56 (Sugammadex); WRE554RFEZ (rocuronium)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121023
[St] Status:MEDLINE


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[PMID]:19521295
[Au] Autor:Liu D; Hu J; Zhang M; Shao Y; Xue H; Wu Q
[Ad] Endereço:Heart Center, First Hospital of Tsinghua University, Beijing, China.
[Ti] Título:Low-dose ketamine combined with pentobarbital in a miniature porcine model for a cardiopulmonary bypass procedure: a randomized controlled study.
[So] Source:Eur J Anaesthesiol;26(5):389-95, 2009 May.
[Is] ISSN:1365-2346
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: Porcine anaesthesia remains a great problem for cardiac surgery research and especially with cardiopulmonary bypass procedures. This study was designed to develop a suitable anaesthesia model in which miniature pigs could be induced smoothly and be maintained stably during and after a cardiopulmonary bypass procedure. METHODS: Thirty-one miniature pigs were randomly divided into two groups and induced using ketamine and pentobarbital (K-P group, n = 15) or pentobarbital (P group, n = 16) alone, respectively. Animals in group K-P were induced with intramuscular injections of ketamine 5 mg kg and pentobarbital 20 mg kg body weight, and those in group P were induced with pentobarbital 30 mg kg alone. After intubation and intravenous catheterization, group K-P was maintained by continuous infusion of ketamine and pentobarbital, and pentobarbital was withdrawn after cardiopulmonary bypass started. Group P received a continuous infusion of pentobarbital throughout the operation. In addition, both groups were injected hourly with midazolam and pipecuronium bolus to achieve optimal surgical conditions. RESULTS: All of the group K-P animals survived for 24 h postoperatively. Five of the group P animals died from anaesthesia-related respiratory and cardiac arrest: three after induction and two after extubation. The animals in group K-P had more stable haemodynamics and arterial blood gas indices than animals in group P. Furthermore, the percentage of animals achieving satisfactory anaesthetic effects was significantly higher in group K-P than in group P. CONCLUSION: Combination anaesthesia with low-dose ketamine and pentobarbital demonstrated superior haemodynamic and respiratory indices in comparison with pentobarbital. The combination regimen can achieve both hypnosis and analgesia effects with stable circulatory parameters.
[Mh] Termos MeSH primário: Anestésicos Combinados/administração & dosagem
Ponte Cardiopulmonar/métodos
Ketamina/administração & dosagem
Pentobarbital/administração & dosagem
[Mh] Termos MeSH secundário: Adjuvantes Anestésicos/administração & dosagem
Anestésicos Dissociativos/administração & dosagem
Animais
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Feminino
Hemodinâmica/efeitos dos fármacos
Injeções Intramusculares
Masculino
Midazolam/administração & dosagem
Pipecurônio/administração & dosagem
Distribuição Aleatória
Respiração/efeitos dos fármacos
Suínos
Porco Miniatura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adjuvants, Anesthesia); 0 (Anesthetics, Combined); 0 (Anesthetics, Dissociative); 1N3O74HM92 (Pipecuronium); 690G0D6V8H (Ketamine); I4744080IR (Pentobarbital); R60L0SM5BC (Midazolam)
[Em] Mês de entrada:0909
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090613
[St] Status:MEDLINE
[do] DOI:10.1097/EJA.0b013e3283229b2a


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Braga, Angélica de Fátima de Assunçäo
Braga, Franklin Sarmento da Silva
Texto completo SciELO Brasil
[PMID]:19082405
[Au] Autor:Braga Ade F; Yoshioka L; Braga FS; Potério GM; Frias JA; Rodrigues Rde C
[Ad] Endereço:Departamento de Anestesiologia, FCM, UNICAMP, Campinas, SP. franklinbraga@terra.com.br
[Ti] Título:Neuromuscular and cardiovascular effects of pipecuronium. A comparative study between different doses.
[So] Source:Rev Bras Anestesiol;58(6):582-92, 2008 Nov-Dec.
[Is] ISSN:1806-907X
[Cp] País de publicação:Brazil
[La] Idioma:eng; por
[Ab] Resumo:BACKGROUND AND OBJECTIVES: Pipecuronium is a non-depolarizing neuromuscular blocker with similar properties to pancuronium, but without cardiovascular effects. Neuromuscular effects, conditions of tracheal intubation, and hemodynamic repercussions of two different doses of pipecuronium were evaluated. METHOD: Patients were divided into two groups according to the dose of pipecuronium: Group I (0.04 mg x kg(-1)) and Group II (0.05 mg x kg(-1)). Intramuscular midazolam (0.1 mg x kg(-1)) was administered 30 minutes before the surgery. Propofol (2.5 mg x kg(-1)), preceded by fentanyl (5 microg x kg(-1)) and pipecuronium (0.04 and 0.05 mg x kg(-1) for Groups I and II, respectively), was administered for anesthetic induction. Patients were ventilated with 100% oxygen via a face mask until a 75% reduction in the amplitude of the response to an isolated stimulus (1 Hz) is achieved, at which time laryngoscopy and intubation were carried out. Anesthetic maintenance was achieved with isoflurane (0.5 to 1%) with a mixture of 50% O2 and N2O. Mechanical ventilation was used to maintain P(ET)CO2 between 32 and 36 mmHg. The pharmacodynamics of pipecuronium was evaluated by acceleromyography. RESULTS: Mean times and standard deviation for the onset of action, clinical duration (T1(25%)), and recovery index (T1(25-75%)) were: Group I (122.10 +/- 4.18 sec, 49.63 +/- 9.54 min, and 48.21 +/- 6.72 min), and Group II (95.78 +/- 8.91 sec, 64.84 +/- 13.13 min, and 48.52 +/- 4.95 min). Onset of action, clinical duration, and conditions of tracheal intubation were significantly different for both groups. CONCLUSIONS: Pipecuronium at a dose of 0.05 mg x kg(-1) can be used in prolonged procedures in which cardiovascular changes should be avoided.
[Mh] Termos MeSH primário: Sistema Cardiovascular/efeitos dos fármacos
Intubação Intratraqueal
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Pipecurônio/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Meia-Idade
Fármacos Neuromusculares não Despolarizantes/farmacologia
Pipecurônio/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuromuscular Nondepolarizing Agents); 1N3O74HM92 (Pipecuronium)
[Em] Mês de entrada:0907
[Cu] Atualização por classe:140205
[Lr] Data última revisão:
140205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081217
[St] Status:MEDLINE


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[PMID]:18582257
[Au] Autor:Thwaites CL; Yen LM; Cordon SM; Thwaites GE; Loan HT; Thuy TT; White NJ; Soni N; Macdonald IA; Farrar JJ
[Ad] Endereço:Oxford University Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, District 5 Ho Chi Minh City, Vietnam. louise.thwaites@btinternet.com
[Ti] Título:Effect of magnesium sulphate on urinary catecholamine excretion in severe tetanus.
[So] Source:Anaesthesia;63(7):719-25, 2008 Jul.
[Is] ISSN:1365-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Severe tetanus is characterised by muscle spasms and autonomic dysfunction. We recently reported the results of a randomised placebo controlled trial of magnesium sulphate infusions for the treatment of severe tetanus which showed magnesium was associated with improved muscle spasm and cardiovascular control. We hypothesised that magnesium controlled autonomic dysfunction by reducing catecholamine release and thus urinary excretion. Urinary adrenaline and noradrenaline concentrations were measured during the first 24 h of therapy in 180 adults with severe tetanus randomised to treatment with magnesium (n = 92) or placebo (n = 88). Magnesium therapy was associated with lower urinary adrenaline excretion and higher urinary noradrenaline excretion. High urinary adrenaline concentrations were associated with documented autonomic dysfunction. Patients given magnesium had significantly less autonomic dysfunction, required less cardiovascular stabilising drugs, and had lower urinary concentrations of adrenaline. These findings suggest adrenaline is important in the pathophysiology of severe tetanus and magnesium controls autonomic dysfunction by reducing adrenaline release.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Epinefrina/urina
Sulfato de Magnésio/farmacologia
Norepinefrina/urina
Tétano/urina
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Anticonvulsivantes/sangue
Anticonvulsivantes/uso terapêutico
Pressão Sanguínea/efeitos dos fármacos
Diazepam/farmacologia
Método Duplo-Cego
Feminino
Frequência Cardíaca/efeitos dos fármacos
Seres Humanos
Sulfato de Magnésio/sangue
Sulfato de Magnésio/uso terapêutico
Masculino
Meia-Idade
Pipecurônio/farmacologia
Tétano/sangue
Tétano/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anticonvulsants); 1N3O74HM92 (Pipecuronium); 7487-88-9 (Magnesium Sulfate); Q3JTX2Q7TU (Diazepam); X4W3ENH1CV (Norepinephrine); YKH834O4BH (Epinephrine)
[Em] Mês de entrada:0807
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:080628
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-2044.2008.05476.x


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[PMID]:18533165
[Au] Autor:Blazewicz A; Fijalek Z; Samsel K
[Ad] Endereço:Department of Pharmaceutical Chemistry, National Medicines Institute, 30/34 Chelmska Street, 00-725 Warsaw, Poland. ablazewicz@il.waw.pl
[Ti] Título:Determination of pipecuronium bromide and its impurities in pharmaceutical preparation by high-performance liquid chromatography with coulometric electrode array detection.
[So] Source:J Chromatogr A;1201(2):191-5, 2008 Aug 08.
[Is] ISSN:0021-9673
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A sensitive and selective HPLC method with coulometric electrode array detection for the determination of pipecuronium bromide and its four impurities has been developed. The coulometric electrode array detection at increasing potentials from +300 to +900mV of the porous graphite electrode versus the palladium reference electrode was used. The limit of detection and quantitation for pipecuronium bromide was 8 and 25ngml(-1), respectively. This elaborate method for the simultaneous analysis of pipecuronium bromide and its impurities proved to be fast, precise, accurate, sensitive, and could be applied to analysis in substances and in pharmaceutical preparations.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Preparações Farmacêuticas/química
Pipecurônio/análise
[Mh] Termos MeSH secundário: Eletroquímica/métodos
Eletrodos
Pipecurônio/química
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Pharmaceutical Preparations); 1N3O74HM92 (Pipecuronium)
[Em] Mês de entrada:0810
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080606
[St] Status:MEDLINE
[do] DOI:10.1016/j.chroma.2008.05.008


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[PMID]:18368836
[Au] Autor:Shabanova SK; Mikhel'son VA; Zhirkova IuV; Agavelian EG; Shaginian AK; Sepbaeva AD
[Ti] Título:[Use of nondepolarizing myorelaxants in neonates].
[So] Source:Anesteziol Reanimatol;(1):26-9, 2008 Jan-Feb.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Mh] Termos MeSH primário: Anestesia Geral/métodos
Atracúrio/análogos & derivados
Atracúrio/uso terapêutico
Bloqueio Neuromuscular/métodos
Fármacos Neuromusculares não Despolarizantes/uso terapêutico
Pipecurônio/uso terapêutico
[Mh] Termos MeSH secundário: Atracúrio/administração & dosagem
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Intubação Intratraqueal
Relaxamento Muscular/efeitos dos fármacos
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Pipecurônio/administração & dosagem
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuromuscular Nondepolarizing Agents); 1N3O74HM92 (Pipecuronium); 2GQ1IRY63P (Atracurium); QX62KLI41N (cisatracurium)
[Em] Mês de entrada:0804
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080329
[St] Status:MEDLINE


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[PMID]:17378780
[Au] Autor:Kirov MY; Lenkin AI; Kuzkov VV; Suborov EV; Slastilin VY; Borodin VV; Chernov II; Shonbin AN; Bjertnaes LJ
[Ad] Endereço:Department of Anaesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russian Federation. kirm@arh.ru
[Ti] Título:Single transpulmonary thermodilution in off-pump coronary artery bypass grafting: haemodynamic changes and effects of different anaesthetic techniques.
[So] Source:Acta Anaesthesiol Scand;51(4):426-33, 2007 Apr.
[Is] ISSN:0001-5172
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Off-pump coronary artery bypass grafting (OPCAB) can be associated with severe cardiovascular changes, thus requiring advanced haemodynamic monitoring. Our aim was to investigate the feasibility of transpulmonary single thermodilution (STD) combined with pulse-contour analysis, a newly introduced method for cardiovascular monitoring, for assessment of changes in haemodynamics during different anaesthetic techniques in OPCAB. METHODS: Thirty-six patients scheduled for elective OPCAB were randomized to receive anaesthesia either with midazolam, propofol or isoflurane, in addition to fentanyl and pipecuronium. After catheterization of the femoral artery, haemodynamic parameters were assessed using STD and pulse-contour analysis. The measurements were performed after induction of anaesthesia, during surgery and at 2, 4 and 6 h post-operatively. RESULTS: At the end of surgery, the global ejection fraction decreased by 29% and 19% in the midazolam and the propofol groups, respectively, (P < 0.05) but remained unchanged in the isoflurane group. Moreover, in the isoflurane group, the left ventricular contractility index was higher and the mean arterial pressure (MAP) and the systemic vascular resistance index (SVRI) decreased in comparison with pre-operative values. Post-operatively, the cardiac index (CI) and the cardiac function index (CFI) increased in all groups (P < 0.05). The peri-operative requirement for ephedrine and nitroglycerin increased in the propofol and the midazolam groups, respectively (P < 0.05). CONCLUSION: During OPCAB, STD and pulse-contour analysis displayed changes in preload, myocardial function and afterload that gave valuable guidance for the conduct of anaesthesia, fluid management, and the administration of vasoactive agents. As assessed using STD, isoflurane within the present dose range appears to maintain myocardial performance and vascular tone better than midazolam or propofol.
[Mh] Termos MeSH primário: Anestesia/métodos
Pressão Sanguínea/efeitos dos fármacos
Ponte de Artéria Coronária sem Circulação Extracorpórea/métodos
Frequência Cardíaca/efeitos dos fármacos
Monitorização Fisiológica/métodos
Resistência Vascular/efeitos dos fármacos
[Mh] Termos MeSH secundário: Idoso
Anestésicos Inalatórios/administração & dosagem
Anestésicos Intravenosos/administração & dosagem
Doença da Artéria Coronariana/cirurgia
Procedimentos Cirúrgicos Eletivos/métodos
Estudos de Viabilidade
Feminino
Fentanila/administração & dosagem
Testes de Função Cardíaca/métodos
Seres Humanos
Isoflurano/administração & dosagem
Masculino
Midazolam/administração & dosagem
Meia-Idade
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Pipecurônio/administração & dosagem
Propofol/administração & dosagem
Volume Sistólico/efeitos dos fármacos
Termodiluição/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anesthetics, Inhalation); 0 (Anesthetics, Intravenous); 0 (Neuromuscular Nondepolarizing Agents); 1N3O74HM92 (Pipecuronium); CYS9AKD70P (Isoflurane); R60L0SM5BC (Midazolam); UF599785JZ (Fentanyl); YI7VU623SF (Propofol)
[Em] Mês de entrada:0707
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070324
[St] Status:MEDLINE


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[PMID]:16790635
[Au] Autor:Peták F; Hantos Z; Adamicza A; Gálity H; Habre W
[Ad] Endereço:Department of Medical Informatics, University of Szeged, Hungary.
[Ti] Título:Development of bronchoconstriction after administration of muscle relaxants in rabbits with normal or hyperreactive airways.
[So] Source:Anesth Analg;103(1):103-9, table of contents, 2006 Jul.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neuromuscular blocking drugs can induce intraoperative bronchospasm. We characterized the magnitude and the temporal profile of the constriction in normal or in hyperresponsive airways after injections of neuromuscular blocking drugs. Respiratory system impedance (Zrs) was measured continuously over a 90-s apneic period in naïve and rabbits sensitized to allergens by ovalbumin. Fifteen s after the start of Zrs recordings, succinylcholine, mivacurium, or pipecuronium was administered in random order. Zrs was then also recorded during the administration of increasing doses of exogenous histamine. To monitor the changes in the airway mechanics during these maneuvers, Zrs was averaged for 2-s time windows, and the airway resistance (Raw) was determined by model fitting. The increases in Raw were significantly larger in the sensitized rabbits than in the naïve animals. The largest increases in Raw and the maximum rate of change in Raw were obtained for succinylcholine (146% +/- 29% and 0.80 +/- 0.12 cm H2O/L, respectively) and mivacurium (80% +/- 25% and 0.71 +/- 0.13 cm H2O/L) and the smallest were obtained for pipecuronium (40% +/- 12% and 0.41 +/- 0.04 cm H2O/L). Allergic sensitization leads to severe and rapidly developing bronchospasm after administrations of mivacurium or succinylcholine. These deleterious side effects should be considered when succinylcholine or mivacurium is administered in the presence of bronchial hyperreactivity.
[Mh] Termos MeSH primário: Hiper-Reatividade Brônquica/fisiopatologia
Broncoconstrição/efeitos dos fármacos
Bloqueadores Neuromusculares/farmacologia
[Mh] Termos MeSH secundário: Resistência das Vias Respiratórias
Animais
Histamina/farmacologia
Isoquinolinas/farmacologia
Pipecurônio/farmacologia
Coelhos
Hipersensibilidade Respiratória/fisiopatologia
Succinilcolina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Isoquinolines); 0 (Neuromuscular Blocking Agents); 1N3O74HM92 (Pipecuronium); 77D66S9Q93 (mivacurium); 820484N8I3 (Histamine); J2R869A8YF (Succinylcholine)
[Em] Mês de entrada:0608
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:060623
[St] Status:MEDLINE


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Fotocópia
[PMID]:15573726
[Au] Autor:Buniatian AA; Vyzhigina MA; Mizikov VM; Deshko IuV; Kozhevnikov VA; Zhukova SG; Batchaev ShS
[Ti] Título:[New russian myorelaxant vero-pipecuronium (pipecuronium bromide) used for the anesthetic management of operations on the thorax and abdomen organs].
[Ti] Título:Novyi otechestvennyi miorelaksant vero-pipekuronii (pipekuronii bromid) v anesteziologicheskom obespechenii operatsii na organakh grudnoi i briushnoi polosti..
[So] Source:Anesteziol Reanimatol;(5):49-52, 2004 Sep-Oct.
[Is] ISSN:0201-7563
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The experience of clinical use of the new Russian myorelaxant of the non-depolarizing action vero-pipecuronium (pipecuronium bromided) manufactured by "Veropharm" is described. Vero-pipecuronium was found to ensure splendid and good conditions for the intubation of the trachea and to maintain reliably myorelaxation. The recommended doses and availability of an antidote (prozerine) provide for a sufficiently controllable myorelaxation. Vero-pipecuronium does not virtually exert any effect on the parameters of hemodynamics and can be successfully used in patients with a high anesthetic risk including heart surgeries. Thus, Russian vero-pipecuronium has now an effective and safe myorelaxant manufactured inside the country, whose parameters are not inferior to those of pipecuronium bromide (arduan) manufactured by "Gedeon Richter", Hungary. Since the described drug is made in Russia, one can hope it will be highly effective both economically and pharmacologically.
[Mh] Termos MeSH primário: Abdome/cirurgia
Anestesia Geral
Relaxamento Muscular/efeitos dos fármacos
Fármacos Neuromusculares não Despolarizantes/uso terapêutico
Pipecurônio/uso terapêutico
Cirurgia Torácica/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Hemodinâmica/efeitos dos fármacos
Seres Humanos
Intubação Intratraqueal
Meia-Idade
Monitorização Intraoperatória
Fármacos Neuromusculares não Despolarizantes/administração & dosagem
Pipecurônio/administração & dosagem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuromuscular Nondepolarizing Agents); 1N3O74HM92 (Pipecuronium)
[Em] Mês de entrada:0505
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041203
[St] Status:MEDLINE



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