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[PMID]: | 27264435 |
[Au] Autor: | Schenk S; Foote J; Aronsen D; Bukholt N; Highgate Q; Van de Wetering R; Webster J |
[Ad] Endereço: | School of Psychology, Victoria University of Wellington, Wellington, New Zealand. Electronic address: susan.schenk@vuw.ac.nz. |
[Ti] Título: | Serotonin antagonists fail to alter MDMA self-administration in rats. |
[So] Source: | Pharmacol Biochem Behav;148:38-45, 2016 Sep. | [Is] ISSN: | 1873-5177 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Acute exposure to ±3,4-methylenedioxymethamphetamine (MDMA) preferentially increases release of serotonin (5-HT), and a role of 5-HT in many of the behavioral effects of acute exposure to MDMA has been demonstrated. A role of 5-HT in MDMA self-administration in rats has not, however, been adequately determined. Therefore, the present study measured the effect of pharmacological manipulation of some 5-HT receptor subtypes on self-administration of MDMA. Rats received extensive experience with self-administered MDMA prior to tests with 5-HT ligands. Doses of the 5-HT1A antagonist, WAY 100635 (0.1-1.0mg/kg), 5-HT1B antagonist, GR 127935 (1.0-3.0mg/kg), and the 5-HT2A antagonist, ketanserin (1.0-3.0mg/kg) that have previously been shown to decrease self-administration of other psychostimulants and that decreased MDMA-produced hyperactivity in the present study did not alter MDMA self-administration. Experimenter-administered injections of MDMA (10.0mg/kg, ip) reinstated extinguished drug-taking behavior, but this also was not decreased by any of the antagonists. In contrast, both WAY 100635 and ketanserin, but not GR 127935, decreased cocaine-produced drug seeking in rats that had been trained to self-administered cocaine. The 5-HT1A agonist, 8-OH-DPAT (0.1-1.0mg/kg), but not the 5-HT1B/1A agonist, RU 24969 (0.3-3.0mg/kg), decreased drug-seeking produced by the reintroduction of a light stimulus that had been paired with self-administered MDMA infusions. These findings suggest a limited role of activation of 5-HT1A, 5-HT1B or 5-HT2 receptor mechanisms in MDMA self-administration or in MDMA-produced drug-seeking following extinction. The data suggest, however, that 5-HT1A agonists inhibit cue-induced drug-seeking following extinction of MDMA self-administration and might, therefore, be useful adjuncts to therapies to limit relapse to MDMA use. |
[Mh] Termos MeSH primário: |
N-Metil-3,4-Metilenodioxianfetamina/administração & dosagem Autoadministração Antagonistas da Serotonina/farmacologia
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[Mh] Termos MeSH secundário: |
8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia Animais Comportamento de Procura de Droga/efeitos dos fármacos Extinção Psicológica Ketanserina/farmacologia Masculino Oxidiazóis/farmacologia Piperazinas/farmacologia Piridinas/farmacologia Ratos Ratos Sprague-Dawley
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Oxadiazoles); 0 (Piperazines); 0 (Pyridines); 0 (Serotonin Antagonists); 2LLH6CEB40 (GR 127935); 71IH826FEG (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide); 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin); 97F9DE4CT4 (Ketanserin); KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) |
[Em] Mês de entrada: | 1708 |
[Cu] Atualização por classe: | 171116 |
[Lr] Data última revisão:
| 171116 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160607 |
[St] Status: | MEDLINE |
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