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[PMID]: | 29252407 |
[Au] Autor: | Wu T; Smith J; Nie H; Wang Z; Erwin PJ; van Wijnen AJ; Qu W |
[Ad] Endereço: | From the Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota (TW, JS, WQ); Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota (HN, AJvW); Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota (ZW); Medical Library, Mayo Clinic, Rochester, Minnesota (PJE); Division of Pain Medicine, Mayo Clinic, Rochester, Minnesota (WQ); and Spine Center, Mayo Clinic, Rochester, Minnesota (WQ). |
[Ti] Título: | Cytotoxicity of Local Anesthetics in Mesenchymal Stem Cells. |
[So] Source: | Am J Phys Med Rehabil;97(1):50-55, 2018 Jan. | [Is] ISSN: | 1537-7385 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | Cell therapy based on the trophic, mitogenic, and immunomodulatory capacity of mesenchymal stem cells is a promising treatment modality for degenerative musculoskeletal conditions. Local anesthetics have been commonly used in interventional procedures for alleviating pain, but local anesthetics may have negative impact on MSC dosing because of cytotoxicity or other biological effects. Because previous studies have not reached consensus yet on the potential complications of local anesthetics in cell therapy, we reviewed 11 studies that involve in vitro experimentation with MSCs using aminoamide-type anesthetics including lidocaine, ropivacaine, mepivacaine, bupivacaine, articaine, and prilocaine. Three studies that compare the effects of different types of local anesthetic agents showed that ropivacaine has the least detrimental effects on mesenchymal stem cell populations, whereas lidocaine seems to have the most significant effects on stem cell viability. Concentration- and time-dependent effects on cell viability were reported with bupivacaine, ropivacaine, lidocaine, and mepivacaine. We conclude that local anesthetic agents have time- and concentration-dependent detrimental effects on MSCs. However, in vivo studies will be required to understand the interactions of these agents with MSCs, because in vitro studies cannot replicate the pharmacokinetics of anesthetics in vivo or the recovery of MSCs in a more physiological environment. |
[Mh] Termos MeSH primário: |
Amidas/toxicidade Anestésicos Locais/toxicidade Bupivacaína/toxicidade Lidocaína/toxicidade Mepivacaína/toxicidade Células Mesenquimais Estromais/efeitos dos fármacos
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[Mh] Termos MeSH secundário: |
Anestesia Local/estatística & dados numéricos Seres Humanos
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Amides); 0 (Anesthetics, Local); 7IO5LYA57N (ropivacaine); 98PI200987 (Lidocaine); B6E06QE59J (Mepivacaine); Y8335394RO (Bupivacaine) |
[Em] Mês de entrada: | 1712 |
[Cu] Atualização por classe: | 171227 |
[Lr] Data última revisão:
| 171227 |
[Sb] Subgrupo de revista: | AIM; IM |
[Da] Data de entrada para processamento: | 171219 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1097/PHM.0000000000000837 |
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