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[PMID]: 25641153 [Au] Autor: Hao Q; Wei X; Yin Q; Mi R; Yuan F; Ai H; Wang P; Chen L; Song Y [Ad] Endereço: Department of Hematology, the Affiliated Cancer Hospital of Zhengzhou University; Henan Cancer Hospital. Zhengzhou 450008, China. [Ti] Título: [Efficacy analysis of CHAG priming regimen as induction therapy for newly diagnosed acute myelogenous leukemia]. [So] Source: Zhonghua Xue Ye Xue Za Zhi;36(1):68-9, 2015 Jan. [Is] ISSN: 0253-2727 [Cp] País de publicação: China [La] Idioma: chi [Mh] Termos MeSH primário: Leucemia Mieloide Aguda [Mh] Termos MeSH secundário: Glutetimida/análogos & derivados Seres Humanos Terapia Neoadjuvante [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 115883-22-2 (cyclohexylaminoglutethimide); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 1512 [Cu] Atualização por classe: 150202 [Lr] Data última revisão: 150202 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150203 [St] Status: MEDLINE [do] DOI: 10.3760/cma.j.issn.0253-2727.2015.01.018

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[PMID]: 22967387 [Au] Autor: Chen L; Wei XD; Yin QS [Ti] Título: [Comparative evaluation of CHAG and CAG priming regimen for treatment of refractory and relapsed acute myeloid leukemia]. [So] Source: Zhonghua Xue Ye Xue Za Zhi;33(6):484-6, 2012 Jun. [Is] ISSN: 0253-2727 [Cp] País de publicação: China [La] Idioma: chi [Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico Leucemia Mieloide Aguda/tratamento farmacológico [Mh] Termos MeSH secundário: Aclarubicina/uso terapêutico Adolescente Adulto Citarabina/uso terapêutico Feminino Glutetimida/administração & dosagem Glutetimida/análogos & derivados Fator Estimulador de Colônias de Granulócitos/uso terapêutico Seres Humanos Masculino Meia-Idade Resultado do Tratamento Adulto Jovem [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 04079A1RDZ (Cytarabine); 115883-22-2 (cyclohexylaminoglutethimide); 143011-72-7 (Granulocyte Colony-Stimulating Factor); 74KXF8I502 (Aclarubicin); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 1310 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 120913 [St] Status: MEDLINE

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[PMID]: 21990141 [Au] Autor: Liu Z; Jia F; Wang W; Wang C; Liu Y [Ad] Endereço: School of Chemical and Biological Science and Engineering, Yantai University, People's Republic of China. [Ti] Título: Determination of phenformin hydrochloride using molecular imprinting technology coupled with flow-injection chemiluminescence. [So] Source: Luminescence;27(4):297-301, 2012 Jul-Aug. [Is] ISSN: 1522-7243 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A novel method was developed using molecular imprinting technology (MIT) coupled with flow-injection chemiluminescence (FI-CL) for highly sensitive detection of phenformin hydrochloride (PH). The phenformin imprinted polymer was synthesized with methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylate (EGDMA) as a cross-linker. Newly synthesized molecularly imprinted polymer (MIP) particles were packed into a column as a selective recognition element for determination of PH. A CL method for the determination of PH was developed based on the CL reaction of PH with N-bromosuccinimide sensitized by eosin Y in basic media. The optimization of detection conditions was investigated. The CL intensity responded linearly to the concentration of PH in the range 0.09-2.0 µg/mL, with a correlation coefficient of 0.9920. The detection limit was 0.031 µg/mL. The relative standard deviation for the determination of 1.0 µg/mL PH solution was 1.0% (n = 11). The method was applied to the determination of PH in urine samples, with satisfactory results. [Mh] Termos MeSH primário: Análise de Injeção de Fluxo/métodos Glutetimida/análogos & derivados Hipoglicemiantes/urina Medições Luminescentes/métodos Polímeros/química [Mh] Termos MeSH secundário: Adsorção Adulto Feminino Análise de Injeção de Fluxo/instrumentação Glutetimida/química Glutetimida/urina Seres Humanos Hipoglicemiantes/química Medições Luminescentes/instrumentação Impressão Molecular Polímeros/síntese química [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hypoglycemic Agents); 0 (Polymers); 679RC9H8TG (phenglutarimide); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 1301 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 111013 [St] Status: MEDLINE [do] DOI: 10.1002/bio.1350

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[PMID]: 21502792 [Au] Autor: Petik D; Czeizel B; Banhidy F; Czeizel AE [Ad] Endereço: Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary. [Ti] Título: A study of the risk of mental retardation among children of pregnant women who have attempted suicide by means of a drug overdose. [So] Source: J Inj Violence Res;4(1):10-9, 2012 Jan. [Is] ISSN: 2008-4072 [Cp] País de publicação: Iran [La] Idioma: eng [Ab] Resumo: BACKGROUND: The aim of the study was to estimate the effect on the fetal development of high doses of prescription drugs taken as a suicide attempt during pregnancy. METHODS: Pregnant women were identified among self-poisoned females in the toxicological inpatient clinic in Budapest between 1960 and 1993. Congenital abnormalities, intrauterine development based on birth weight and post-conceptional age, mental retardation, cognitive-behavioral status were compared in exposed children born to mothers who had attempted suicide by means of a drug overdose during pregnancy with their siblings, born either before or after the affected pregnancy, as sib controls. RESULTS: Of a total of 1 044 pregnant women, 74 used the combination of amobarbital, glutethimide and promethazine (Tardyl®, one of the most popular drugs for treatment of insomnia in Hungary) for suicide attempt. Of these 74 women, 27 delivered live-born babies. The mean dose of Tardyl® used for suicide attempts was 24 times the usually prescribed clinical dose. The rate of congenital abnormalities and intrauterine retardation was not higher in exposed children than in their sib controls. However, of the 27 exposed children, eight (29.6%) were mentally retarded (X²1=79.7, p= Sig) while mental retardation did not occur among 46 sib controls. These exposed children were born to mothers who attempted suicide with Tardyl® between the 14th and 20th post-conceptional weeks. The components of Tardyl® used separately for a suicide attempt during pregnancy were not associated with a higher risk of mental retardation. Therefore the high doses of Tardyl® associated with the high risk for mental retardation may be due to the interaction of its three drug components. CONCLUSIONS: The findings of the study showed that the high doses of a drug containing three components may be associated with a significantly increased risk for mental retardation without any structural defects, whereas each of these three component drugs taken alone was not associated with this adverse effect. [Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/epidemiologia Desenvolvimento Fetal/efeitos dos fármacos Deficiência Intelectual/epidemiologia Gestantes/psicologia Tentativa de Suicídio/psicologia [Mh] Termos MeSH secundário: Adulto Amobarbital/envenenamento Peso ao Nascer Distribuição de Qui-Quadrado Combinação de Medicamentos Overdose de Drogas Feminino Idade Gestacional Glutetimida/envenenamento Seres Humanos Hungria/epidemiologia Modelos Logísticos Gravidez Resultado da Gravidez Efeitos Tardios da Exposição Pré-Natal Prometazina/envenenamento Fatores de Risco Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico Tentativa de Suicídio/estatística & dados numéricos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Drug Combinations); C8I4BVN78E (Glutethimide); FF28EJQ494 (Promethazine); GWH6IJ239E (Amobarbital) [Em] Mês de entrada: 1202 [Cu] Atualização por classe: 150204 [Lr] Data última revisão: 150204 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 110420 [St] Status: MEDLINE [do] DOI: 10.5249/jivr.v4i1.85

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[PMID]: 18818183 [Au] Autor: Petik D; Acs N; Bánhidy F; Czeizel AE [Ad] Endereço: Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary. [Ti] Título: A study of the effects of large doses of glutethimide that were used for self-poisoning during pregnancy on human fetuses. [So] Source: Toxicol Ind Health;24(1-2):69-78, 2008 Feb-Mar. [Is] ISSN: 0748-2337 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Animal investigations showed some embryolethal and teratogenic effects of glutethimide, a piperidindion derivative non-barbital hypnotic drug. Thus, the objective of this study was to evaluate the effects of very large doses of glutethimide that were used for a suicide attempt during pregnancy on the embryo-fetal development of exposed children. Self-poisoned pregnant women were identified from the population of female patients of the Department of Toxicology Internal Medicine, Korányi Hospital, Budapest who had been admitted from the 3 million people of Budapest and its surrounding region. The rates of congenital abnormalities, intrauterine fetal development (based on birth weight and pregnancy age at delivery) and cognitive-behavioral status of exposed children born to mothers who attempted suicide with glutethimide alone or in combination with other drugs during pregnancy were compared with their sib controls. Of 1044 pregnant women with self-poisoning during pregnancy between 1960 and 1993, 33 used glutethimide for a suicide attempt sixteen of these women delivered live-born infants. The dose of glutethimide ranged between 1000 and 15,000 mg with a mean of 4234 mg. Of the 16 exposed children, five were male and 11 were female. Three exposed children were affected with congenital abnormalities (atrial septal defect type II, pectus carinatum, fetal alcohol syndrome). Of their 16 matched unexposed sib pairs, two had congenital abnormalities. The mean birth weight of the exposed children was somewhat larger due to somewhat longer pregnancy age at delivery. Cognitive status and behavioral scale of the exposed children did not indicate a fetotoxic (including neurotoxic) effect of large doses of glutethimide. Very large doses of glutethimide used for a suicide attempt by 16 pregnant women did not produce teratogenic or fetotoxic (including neurotoxic) effects in their children. [Mh] Termos MeSH primário: Anormalidades Induzidas por Medicamentos/etiologia Desenvolvimento Fetal/efeitos dos fármacos Glutetimida/envenenamento Gestantes Tentativa de Suicídio/estatística & dados numéricos [Mh] Termos MeSH secundário: Anormalidades Induzidas por Medicamentos/epidemiologia Adolescente Adulto Estudos de Casos e Controles Relação Dose-Resposta a Droga Feminino Seres Humanos Hungria/epidemiologia Hipnóticos e Sedativos/envenenamento Recém-Nascido Masculino Gravidez Efeitos Tardios da Exposição Pré-Natal Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Hypnotics and Sedatives); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 0901 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 080927 [St] Status: MEDLINE [do] DOI: 10.1177/0748233708089014

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[PMID]: 17623465 [Au] Autor: Wetli HA; Francotte E [Ad] Endereço: Discovery Technologies, Novartis Institutes for BioMedical Research, Basel, Switzerland. [Ti] Título: Automated screening platform with isochronal-parallel analysis and conditioning for rapid method development of chiral separations. [So] Source: J Sep Sci;30(9):1255-61, 2007 Jun. [Is] ISSN: 1615-9306 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: An automated chiral separation-screening platform was developed, allowing separation analysis on one column while another column is simultaneously equilibrated with a different mobile phase (MP). The platform can be set up from usual HPLC components at moderate cost and it considerably speeds up the screening process, allowing numerous chromatographic conditions to be tested within a short period of time and leading to a significant gain in time and productivity in preparative separations. [Mh] Termos MeSH primário: Benzoína/isolamento & purificação Técnicas de Química Analítica/instrumentação Etanol/análogos & derivados Etanol/isolamento & purificação Glutetimida/isolamento & purificação [Mh] Termos MeSH secundário: Autoanálise Cromatografia Líquida de Alta Pressão/instrumentação Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 3K9958V90M (Ethanol); C8I4BVN78E (Glutethimide); L7J6A1NE81 (Benzoin) [Em] Mês de entrada: 0708 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 070712 [St] Status: MEDLINE

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[PMID]: 17602675 [Au] Autor: Siraki AG; Bonini MG; Jiang J; Ehrenshaft M; Mason RP [Ad] Endereço: Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA. sirakia@niehs.nih.gov [Ti] Título: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. [So] Source: Chem Res Toxicol;20(7):1038-45, 2007 Jul. [Is] ISSN: 0893-228X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Aminoglutethimide (AG) is a first-generation aromatase inhibitor used for estrogen-dependent breast cancer. Unfortunately, its use has also been associated with agranulocytosis. We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical. We hypothesized that AG oxidation by MPO/H2O2 would produce an AG cation radical that, in the absence of a biochemical reductant, would lead to the oxidation of MPO. We utilized a novel anti-DMPO antibody to detect DMPO (5,5-dimethyl-1-pyrroline N-oxide) covalently bound to protein, which forms only by the reaction of DMPO with a protein free radical. We found that AG metabolism by MPO/H2O2 induced the formation of DMPO-MPO, which was inhibited by MPO inhibitors and ascorbate. Glutethimide, a congener of AG that lacks the aromatic amine, did not cause DMPO-MPO formation, indicating the necessity of oxidation of the aniline moiety in AG. When analyzed by electron spin resonance spectroscopy, we detected a phenyl radical adduct, derived from AG, which may be involved in the free radical formation on MPO. Furthermore, we also found protein-DMPO adducts in MPO-containing, intact human promyelocytic leukemia cells (HL-60). MPO was affinity-purified from HL-60 cells treated with AG/H2O2 and was found to contain DMPO. These findings were also supported by the detection of protein free radicals with electron spin resonance in the cellular cytosolic lysate. The formation of an MPO protein free radical is believed to be mediated by one of two free radical drug metabolites of AG, one of which was characterized by spin trapping with 2-methyl-2-nitrosopropane. These results are the first demonstration of MPO free-radical detection by the anti-DMPO antibody that results from drug oxidation. We propose that drug-dependent free radical formation on MPO may play a role in the origin of agranulocytosis. [Mh] Termos MeSH primário: Agranulocitose/metabolismo Aminoglutetimida/farmacologia Radicais Livres/metabolismo Peroxidase/metabolismo [Mh] Termos MeSH secundário: Trifosfato de Adenosina/química Trifosfato de Adenosina/metabolismo Agranulocitose/induzido quimicamente Aminoglutetimida/química Compostos de Anilina/química Compostos de Anilina/metabolismo Inibidores da Aromatase/química Inibidores da Aromatase/farmacologia Ácido Ascórbico/química Ácido Ascórbico/metabolismo Western Blotting Cromatografia de Afinidade Óxidos N-Cíclicos/química Óxidos N-Cíclicos/metabolismo Relação Dose-Resposta a Droga Espectroscopia de Ressonância de Spin Eletrônica Ensaio de Imunoadsorção Enzimática Radicais Livres/química Glucose/química Glucose/metabolismo Glutetimida/química Glutetimida/metabolismo Células HL-60 Seres Humanos Peróxido de Hidrogênio/química Peróxido de Hidrogênio/metabolismo Óxidos de Nitrogênio/química Óxidos de Nitrogênio/metabolismo Compostos Nitrosos/química Compostos Nitrosos/metabolismo Espectrofotometria [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL [Nm] Nome de substância: 0 (Aniline Compounds); 0 (Aromatase Inhibitors); 0 (Cyclic N-Oxides); 0 (Free Radicals); 0 (Nitrogen Oxides); 0 (Nitroso Compounds); 0O54ZQ14I9 (Aminoglutethimide); 5351-17-7 (4-aminobenzhydrazide); 7170JZ1QF3 (5,5-dimethyl-1-pyrroline-1-oxide); 8L70Q75FXE (Adenosine Triphosphate); BBX060AN9V (Hydrogen Peroxide); C8I4BVN78E (Glutethimide); EC 1.11.1.7 (Peroxidase); GFQ4MMS07W (nitroxyl); IY9XDZ35W2 (Glucose); JGX6N17V2U (tert-nitrosobutane); PQ6CK8PD0R (Ascorbic Acid) [Em] Mês de entrada: 0710 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 070703 [St] Status: MEDLINE

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[PMID]: 16033334 [Au] Autor: Kolluri S; Sadlon TJ; May BK; Bonkovsky HL [Ad] Endereço: Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, Farmington, CT 06030, USA. [Ti] Título: Haem repression of the housekeeping 5-aminolaevulinic acid synthase gene in the hepatoma cell line LMH. [So] Source: Biochem J;392(Pt 1):173-80, 2005 Nov 15. [Is] ISSN: 1470-8728 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Haem is essential for the health and function of nearly all cells. 5-Aminolaevulinic acid synthase-1 (ALAS-1) catalyses the first and rate-controlling step of haem biosynthesis. ALAS-1 is repressed by haem and is induced strongly by lipophilic drugs that also induce CYP (cytochrome P450) proteins. We investigated the effects on the avian ALAS-1 gene promoter of a phenobarbital-like chemical, Glut (glutethimide), and a haem synthesis inhibitor, DHA (4,6-dioxoheptanoic acid), using a reporter gene assay in transiently transfected LMH (Leghorn male hepatoma) hepatoma cells. A 9.1 kb cALAS-1 (chicken ALAS-1) promoter-luciferase-reporter construct, was poorly induced by Glut and not by DHA alone, but was synergistically induced by the combination. In contrast, a 3.5 kb promoter ALAS-1 construct was induced by Glut alone, without any further effect of DHA. In addition, exogenous haem (20 microM) repressed the basal and Glut- and DHA-induced activity of luciferase reporter constructs containing 9.1 and 6.3 kb of ALAS-1 5'-flanking region but not the construct containing the first 3.5 kb of promoter sequence. This effect of haem was subsequently shown to be dependent on the -6.3 to -3.5 kb region of the 5'-flanking region of cALAS-1 and requires the native orientation of the region. Two deletion constructs of this approx. 2.8 kb haem-repressive region (1.7 and 1.1 kb constructs) retained haem-dependent repression of basal and drug inductions, suggesting that more than one cis-acting elements are responsible for this haem-dependent repression of ALAS-1. These results demonstrate that there are regulatory regions in the 5'-flanking region of the cALAS-1 gene that respond to haem and provide a basis for further investigations of the molecular mechanisms by which haem down-regulates expression of the ALAS-1 gene. [Mh] Termos MeSH primário: 5-Aminolevulinato Sintetase/genética Regulação para Baixo/efeitos dos fármacos Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos Heme/farmacologia [Mh] Termos MeSH secundário: Animais Linhagem Celular Tumoral Galinhas Sinergismo Farmacológico Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos Glutetimida/farmacologia Heme/antagonistas & inibidores Heme/metabolismo Heptanoatos/farmacologia Regiões Promotoras Genéticas/genética Regulação para Cima/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, P.H.S. [Nm] Nome de substância: 0 (Heptanoates); 42VZT0U6YR (Heme); 51568-18-4 (succinylacetone); C8I4BVN78E (Glutethimide); EC 2.3.1.37 (5-Aminolevulinate Synthetase) [Em] Mês de entrada: 0602 [Cu] Atualização por classe: 161203 [Lr] Data última revisão: 161203 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 050722 [St] Status: MEDLINE

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[PMID]: 15912539 [Au] Autor: Rocheleau MJ [Ad] Endereço: Pharmaceutical Research Institute Bristol-Myers Squibb, Candiac, Québec, Canada. marie.rocheleau@bms.com [Ti] Título: Generic capillary electrophoresis conditions for chiral assay in early pharmaceutical development. [So] Source: Electrophoresis;26(12):2320-9, 2005 Jun. [Is] ISSN: 0173-0835 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Generic capillary electrophoresis (CE) conditions have been implemented for chiral separations in early pharmaceutical development. The chiral CE separations of several pharmaceutical samples at different stages of development, i.e., discovery, process chemistry, and investigative new drug application, have been obtained using sulfated beta-cyclodextrin (CD). Several sulfated beta-CDs have been screened to select an appropriate enantioselective agent. The use of a generic CE method allows for a convenient and rapid chiral recognition of different weak bases, with minimal or no method development. CE using sulfated beta-CD for the chiral separation of N-benzoyl methyl piperazine has been validated for linearity, precision, accuracy, limits of detection and quantitation (LOD, LOQ). Although less sensitive than a specific liquid chromatography method using a Chiralpak AD column, the overall performance of the chiral CE method was found comparable. Validation data demonstrate that a LOD of 0.1%, sufficient to fulfill regulatory requirements, is achievable by chiral CE. [Mh] Termos MeSH primário: Eletroforese Capilar/métodos [Mh] Termos MeSH secundário: Indústria Farmacêutica Glutetimida/isolamento & purificação Piperazinas/isolamento & purificação Estereoisomerismo Ésteres do Ácido Sulfúrico beta-Ciclodextrinas [Pt] Tipo de publicação: EVALUATION STUDIES; JOURNAL ARTICLE [Nm] Nome de substância: 0 (N-benzoylmethylpiperazine); 0 (Piperazines); 0 (Sulfuric Acid Esters); 0 (beta-Cyclodextrins); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 0509 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 050525 [St] Status: MEDLINE

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[PMID]: 15587581 [Au] Autor: Aboul-Enein HY; Ali I [Ad] Endereço: Pharmaceutical Analysis Laboratory, Biological and Medical Research Department (MBC-03), King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. enein@kfshrc.edu.sa [Ti] Título: Enantiomeric separation of glutethimide derivatives using a Ceramospher RU-2 column. [So] Source: Pharmazie;59(11):833-5, 2004 Nov. [Is] ISSN: 0031-7144 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: The enantiomeric resolution of p-acetylaminoglutethimide and p-nitroglutethimide was achieved on a Ceramospher RU-2 column using methanol as the mobile phase. The flow rates of the mobile phase were 1.0 and 0.5 mL/min for p-acetylaminoglutethimide and p-nitroglutethimide, respectively, with UV detection at 254 nm. The values of alpha of the resolved enantiomers of p-acetylaminoglutethimide and p-nitroglutethimide were 1.63 and 1.24 while the values of Rs were 1.44 and 0.86 respectively. The possible chiral mechanism was the formation of transient diastereomeric intermediates between the enantiomers and the chiral selector (1,10-phenanthroline) ruthenium II complex which was stabilized by pi-pi interactions. [Mh] Termos MeSH primário: Anticonvulsivantes/isolamento & purificação Glutetimida/isolamento & purificação [Mh] Termos MeSH secundário: Anticonvulsivantes/química Cromatografia Líquida de Alta Pressão Glutetimida/química Indicadores e Reagentes Compostos Organometálicos/química Rutênio/química Espectrofotometria Ultravioleta Estereoisomerismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anticonvulsants); 0 (Indicators and Reagents); 0 (Organometallic Compounds); 7UI0TKC3U5 (Ruthenium); C8I4BVN78E (Glutethimide) [Em] Mês de entrada: 0501 [Cu] Atualização por classe: 131121 [Lr] Data última revisão: 131121 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 041214 [St] Status: MEDLINE

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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