Base de dados : MEDLINE
Pesquisa : D03.383.663.283 [Categoria DeCS]
Referências encontradas : 8172 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 818 ir para página                         

  1 / 8172 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28465426
[Au] Autor:Pryke KM; Abraham J; Sali TM; Gall BJ; Archer I; Liu A; Bambina S; Baird J; Gough M; Chakhtoura M; Haddad EK; Kirby IT; Nilsen A; Streblow DN; Hirsch AJ; Smith JL; DeFilippis VR
[Ad] Endereço:Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, Oregon, USA.
[Ti] Título:A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.
[So] Source:MBio;8(3), 2017 May 02.
[Is] ISSN:2150-7511
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ongoing concurrent outbreaks of Zika, Chikungunya, and dengue viruses in Latin America and the Caribbean highlight the need for development of broad-spectrum antiviral treatments. The type I interferon (IFN) system has evolved in vertebrates to generate tissue responses that actively block replication of multiple known and potentially zoonotic viruses. As such, its control and activation through pharmacological agents may represent a novel therapeutic strategy for simultaneously impairing growth of multiple virus types and rendering host populations resistant to virus spread. In light of this strategy's potential, we undertook a screen to identify novel interferon-activating small molecules. Here, we describe 1-(2-fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3- ]pyrrole-3,9-dione, which we termed AV-C. Treatment of human cells with AV-C activates innate and interferon-associated responses that strongly inhibit replication of Zika, Chikungunya, and dengue viruses. By utilizing genome editing, we investigated the host proteins essential to AV-C-induced cellular states. This showed that the compound requires a TRIF-dependent signaling cascade that culminates in IFN regulatory factor 3 (IRF3)-dependent expression and secretion of type I interferon to elicit antiviral responses. The other canonical IRF3-terminal adaptor proteins STING and IPS-1/MAVS were dispensable for AV-C-induced phenotypes. However, our work revealed an important inhibitory role for IPS-1/MAVS, but not TRIF, in flavivirus replication, implying that TRIF-directed viral evasion may not occur. Additionally, we show that in response to AV-C, primary human peripheral blood mononuclear cells secrete proinflammatory cytokines that are linked with establishment of adaptive immunity to viral pathogens. Ultimately, synthetic innate immune activators such as AV-C may serve multiple therapeutic purposes, including direct antimicrobial responses and facilitation of pathogen-directed adaptive immunity. The type I interferon system is part of the innate immune response that has evolved in vertebrates as a first line of broad-spectrum immunological defense against an unknowable diversity of microbial, especially viral, pathogens. Here, we characterize a novel small molecule that artificially activates this response and in so doing generates a cellular state antagonistic to growth of currently emerging viruses: Zika virus, Chikungunya virus, and dengue virus. We also show that this molecule is capable of eliciting cellular responses that are predictive of establishment of adaptive immunity. As such, this agent may represent a powerful and multipronged therapeutic tool to combat emerging and other viral diseases.
[Mh] Termos MeSH primário: Proteínas Adaptadoras de Transporte Vesicular/agonistas
Antivirais/farmacologia
Benzopiranos/farmacologia
Vírus Chikungunya/fisiologia
Vírus da Dengue/fisiologia
Tiadiazóis/farmacologia
Replicação Viral
Zika virus/fisiologia
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transporte Vesicular/metabolismo
Antivirais/química
Antivirais/isolamento & purificação
Benzopiranos/química
Benzopiranos/isolamento & purificação
Linhagem Celular
Febre de Chikungunya/tratamento farmacológico
Vírus Chikungunya/efeitos dos fármacos
Citocinas/biossíntese
Replicação do DNA/efeitos dos fármacos
Dengue/tratamento farmacológico
Vírus da Dengue/efeitos dos fármacos
Vírus da Dengue/metabolismo
Descoberta de Drogas
Edição de Genes
Interações Hospedeiro-Patógeno
Seres Humanos
Evasão da Resposta Imune
Imunidade Inata/efeitos dos fármacos
Fator Regulador 3 de Interferon/genética
Fator Regulador 3 de Interferon/metabolismo
Interferon Tipo I/efeitos dos fármacos
Interferon Tipo I/metabolismo
Interferon Tipo I/secreção
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/imunologia
Tiadiazóis/química
Tiadiazóis/isolamento & purificação
Zika virus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adaptor Proteins, Vesicular Transport); 0 (Antiviral Agents); 0 (Benzopyrans); 0 (Cytokines); 0 (Interferon Regulatory Factor-3); 0 (Interferon Type I); 0 (TICAM1 protein, human); 0 (Thiadiazoles)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


  2 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28987570
[Au] Autor:Zhou T; Wu L; Luo Y; Christie P
[Ad] Endereço:Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China.
[Ti] Título:Effects of organic matter fraction and compositional changes on distribution of cadmium and zinc in long-term polluted paddy soils.
[So] Source:Environ Pollut;232:514-522, 2018 Jan.
[Is] ISSN:1873-6424
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Soil particulate organic matter (POM) has rapid turnover and metal enrichment, but the interactions between organic matter (OM) and metals have not been well studied. The present study aimed to investigate changes in the OM concentration and composition of the POM fraction and their corresponding effects on metal distribution and extractability in long-term polluted paddy soils. Soil 2000-53 µm POM size fractions had higher contents of C-H and C=O bonds, C-H/C=O ratios and concentrations of fulvic acid (FA), humic acid (HA), cadmium (Cd) and zinc (Zn) than the bulk soils. Cadmium and Zn stocks in soil POM fractions were 24.5-27.9% and 7.12-16.7%, respectively, and were more readily EDTA-extractable. Compared with the control soil, the 2000-250 µm POM size fractions had higher organic carbon concentrations and C/N ratios in the polluted soils. However, there were no significant differences in the contents in C-H and C=O bonds or C-H/C=O ratios of POM fractions among the control, slightly and highly polluted soils. In accordance with the lower contents of C=O bonds and FA and HA concentrations, the Cd and Zn concentrations in 250-53 µm POM size fractions were lower than those in 2000-250 µm POM size fractions. Enrichment of Cd in POM fractions increased with increasing soil pollution level. These results support the view that changes in the OM concentration and the size and composition of POM fractions play a key role in determining the distribution of Cd and Zn in paddy soils.
[Mh] Termos MeSH primário: Cádmio/análise
Monitoramento Ambiental
Substâncias Húmicas/análise
Poluentes do Solo/análise
Zinco/análise
[Mh] Termos MeSH secundário: Agricultura
Benzopiranos
Poluição Ambiental/estatística & dados numéricos
Metais
Material Particulado
Solo/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Humic Substances); 0 (Metals); 0 (Particulate Matter); 0 (Soil); 0 (Soil Pollutants); 00BH33GNGH (Cadmium); J41CSQ7QDS (Zinc); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180119
[Lr] Data última revisão:
180119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171009
[St] Status:MEDLINE


  3 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29272319
[Au] Autor:Min M; Yan BX; Wang P; Landeck L; Chen JQ; Li W; Cai SQ; Zheng M; Man XY
[Ad] Endereço:Department of Dermatology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
[Ti] Título:Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
[So] Source:PLoS One;12(12):e0190051, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rottlerin is a natural polyphenolic compound that was initially indicated as a PKCδ inhibitor. However, it was recently revealed that it may target a number of molecules and have biological effects on various cell types and is considered as a possible agent for tumor and cell proliferative diseases. Psoriasis is a chronic inflammatory cutaneous disorder with undefined etiology and is characterized by abnormal cellular proliferation, angiogenesis, and inflammation. Therefore, this paper investigates the regulatory effects of rottlerin on normal human epidermal keratinocytes (NHEKs) and imiquimod (IMQ)-induced psoriasiform (IPI) lesions. In vitro results showed that rottlerin inhibited cell proliferation in NHEKs through growth arrest and NFκB inhibition. It may also induce apoptosis in an autophagy-dependent pathway. We found that rottlerin inhibited human microvascular endothelial cells tube formation on matrigel. Rottlerin also decreased the cell senescence of keratinocytes and intracellular ROS generation, which indicated its antioxidant effect. We also showed that rottlerin affects the expression of keratinocyte proliferation biomarkers. In 12-O-tetradecanoylphorbol13-acetate (TPA)-induced keratinocytes, rottlerin significantly inhibited the expression of the induced pro-inflammatory cytokines in keratinocytes. An animal experiment provided the corresponding evidence based on this evidence in vitro, by using IPI model, we found that rottlerin could relieve the psoriasiform of BALB/c mice by inhibiting keratinocyte proliferation, inflammatory cell infiltration, and vascular proliferation. In conclusion, our results suggest that rottlerin may prove useful in the development of therapeutic agents against psoriasis. However, the deep mechanism still requires further study.
[Mh] Termos MeSH primário: Acetofenonas/uso terapêutico
Benzopiranos/uso terapêutico
Psoríase/tratamento farmacológico
[Mh] Termos MeSH secundário: Adjuvantes Imunológicos/uso terapêutico
Adolescente
Adulto
Aminoquinolinas/uso terapêutico
Animais
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Feminino
Seres Humanos
Técnicas In Vitro
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Meia-Idade
NF-kappa B/metabolismo
Psoríase/metabolismo
Psoríase/patologia
Espécies Reativas de Oxigênio/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetophenones); 0 (Adjuvants, Immunologic); 0 (Aminoquinolines); 0 (Benzopyrans); 0 (NF-kappa B); 0 (Reactive Oxygen Species); E29LP3ZMUH (rottlerin); P1QW714R7M (imiquimod)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171223
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190051


  4 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28467858
[Au] Autor:Athira AP; Abhinand CS; Saja K; Helen A; Reddanna P; Sudhakaran PR
[Ad] Endereço:a Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala-695581, India.
[Ti] Título:Anti-angiogenic effect of chebulagic acid involves inhibition of the VEGFR2- and GSK-3ß-dependent signaling pathways.
[So] Source:Biochem Cell Biol;95(5):563-570, 2017 Oct.
[Is] ISSN:1208-6002
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Inhibition of angiogenesis is a useful strategy to prevent cancer growth by targeting new vessels that grow to nourish actively proliferating tumor cells. Endothelial cells can use a number of different pathways to cause angiogenesis, and each step in these pathways can be targeted. The use of multi-targeted drugs is gaining much importance in this scenario. Our previous results have shown that chebulagic acid (a benzopyran tannin present in the fruits of Terminalia chebula) has anti-angiogenic properties. Thus, this study was designed to examine the molecular mechanism for the anti-angiogenic effects of chebulagic acid. Results from our investigations using molecular docking studies and human umbilical vein endothelial cells in culture suggested that chebulagic acid inhibits both GSK-3ß-dependent ß-catenin phosphorylation (an important mediator of VE-cadherin-ß-catenin signaling) and VEGFR2 phosphorylation, which is an important step in VEGF signaling. Chebulagic acid inhibits angiogenesis by blocking both the VEGF-VEGFR2 complex and cell-cell contact dependent downstream signaling pathways.
[Mh] Termos MeSH primário: Inibidores da Angiogênese/farmacologia
Benzopiranos/farmacologia
Glucosídeos/farmacologia
Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores
Inibidores de Proteínas Quinases/farmacologia
Transdução de Sinais/efeitos dos fármacos
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores
[Mh] Termos MeSH secundário: Células Cultivadas
Glicogênio Sintase Quinase 3 beta/metabolismo
Seres Humanos
Simulação de Acoplamento Molecular
Fosforilação/efeitos dos fármacos
Inibidores de Proteínas Quinases/química
Relação Estrutura-Atividade
Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Angiogenesis Inhibitors); 0 (Benzopyrans); 0 (Glucosides); 0 (Protein Kinase Inhibitors); 23094-71-5 (chebulagic acid); EC 2.7.10.1 (KDR protein, human); EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2); EC 2.7.11.1 (Glycogen Synthase Kinase 3 beta)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1139/bcb-2016-0132


  5 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29203243
[Au] Autor:Wang Z; Shen GH; Xie JM; Li B; Gao QG
[Ad] Endereço:Department of General Surgery, The First People's Hospital of Wu Jiang, Suzhou, Jiangsu, 215200, China; Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China.
[Ti] Título:Rottlerin upregulates DDX3 expression in hepatocellular carcinoma.
[So] Source:Biochem Biophys Res Commun;495(1):1503-1509, 2018 01 01.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rottlerin has been reported to exert its anti-tumor activity in various types of human cancers. However, the underlying molecular mechanism has not been fully elucidated. In the current study, we explored whether rottlerin exhibits its tumor suppressive function in hepatocellular carcinoma cells. Our MTT assay results showed that rottlerin inhibited cell growth in hepatocellular carcinoma cells. Moreover, we found that rottlerin induced cell apoptosis and caused cell cycle arrest at G1 phase. Furthermore, our wound healing assay result demonstrated that rottlerin retarded cell migration in hepatocellular carcinoma cells. Additionally, rottlerin suppressed cell migration and invasion. Notably, we found that rottlerin upregulated DDX3 expression and subsequently downregulated Cyclin D1 expression and increased p21 level. Importantly, down-regulation of DDX3 abrogated the rottlerin-mediated tumor suppressive function, whereas overexpression of DDX3 promoted the anti-tumor activity of rottlerin. Our study suggests that rottlerin exhibits its anti-cancer activity partly due to upregulation of DDX3 in hepatocellular carcinoma cells.
[Mh] Termos MeSH primário: Acetofenonas/administração & dosagem
Apoptose/efeitos dos fármacos
Benzopiranos/administração & dosagem
Carcinoma Hepatocelular/tratamento farmacológico
Carcinoma Hepatocelular/metabolismo
RNA Helicases DEAD-box/metabolismo
Neoplasias Hepáticas/tratamento farmacológico
Neoplasias Hepáticas/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/administração & dosagem
Carcinoma Hepatocelular/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Neoplasias Hepáticas/patologia
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetophenones); 0 (Antineoplastic Agents); 0 (Benzopyrans); E29LP3ZMUH (rottlerin); EC 3.6.1.- (DDX3X protein, human); EC 3.6.4.13 (DEAD-box RNA Helicases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE


  6 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29240819
[Au] Autor:Boguta P; Sokolowska Z; Skic K
[Ad] Endereço:Department of Physical Chemistry of Porous Materials, Institute of Agrophysics, Polish Academy of Sciences, Lublin, Poland.
[Ti] Título:Use of thermal analysis coupled with differential scanning calorimetry, quadrupole mass spectrometry and infrared spectroscopy (TG-DSC-QMS-FTIR) to monitor chemical properties and thermal stability of fulvic and humic acids.
[So] Source:PLoS One;12(12):e0189653, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thermogravimetry-coupled with differential scanning calorimetry, quadrupole mass spectrometry, and Fourier-transform infrared spectroscopy (TG-DSC-QMS-FTIR)-was applied to monitor the thermal stability (in an N2 pyrolytic atmosphere) and chemical properties of natural polymers, fulvic (FA) and humic acids (HA), isolated from chemically different soils. Three temperature ranges, R1, 40-220°C; R2, 220-430°C; and R3, 430-650°C, were distinguished from the DSC data, related to the main thermal processes of different structures (including transformations without weight loss). Weight loss (ΔM) estimated from TG curves at the above temperature intervals revealed distinct differences within the samples in the content of physically adsorbed water (at R1), volatile and labile functional groups (at R2) as well as recalcitrant and refractory structures (at R3). QMS and FTIR modules enabled the chemical identification (by masses and by functional groups, respectively) of gaseous species evolved during thermal decomposition at R1, R2 and R3. Variability in shape, area and temperature of TG, DSC, QMS and FTIR peaks revealed differences in thermal stability and chemical structure of the samples between the FAs and HAs fractions of different origin. The statistical analysis showed that the parameters calculated from QMS (areas of m/z = 16, 17, 18, 44), DSC (MaxDSC) and TG (ΔM) at R1, R2 and R3 correlated with selected chemical properties of the samples, such as N, O and COOH content as well as E2/E6 and E2/E4 indexes. This indicated a high potential for the coupled method to monitor the chemical changes of humic substances. A new humification parameter, HTD, based on simple calculations of weight loss at specific temperature intervals proved to be a good alternative to indexes obtained from other methods. The above findings showed that the TG-DSC-QMS-FTIR coupled technique can represent a useful tool for the comprehensive assessment of FAs and HAs properties related to their various origin.
[Mh] Termos MeSH primário: Benzopiranos/análise
Varredura Diferencial de Calorimetria/métodos
Substâncias Húmicas/análise
Espectrometria de Massas/métodos
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
Termogravimetria/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Humic Substances); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189653


  7 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28448748
[Au] Autor:Lima LSMS; De Almeida R; Quintaes BR; Bila DM; Campos JC
[Ad] Endereço:a Department of Inorganic Processes, School of Chemistry , Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.
[Ti] Título:Evaluation of humic substances removal from leachates originating from solid waste landfills in Rio de Janeiro State, Brazil.
[So] Source:J Environ Sci Health A Tox Hazard Subst Environ Eng;52(9):828-836, 2017 Jul 29.
[Is] ISSN:1532-4117
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study aimed to evaluate the use of coagulation/flocculation and Fenton processes for the removal of the recalcitrant component, in particular humic substances, from two different leachates generated in the Gericinó and Gramacho landfills in Rio de Janeiro State (Brazil). A coagulation/flocculation process, using FeCl ·6H O as the coagulant, was applied to the two leachate samples. In the case of the leachate from Gericinó landfill, the treatment removed 93% of color, 71% of TOC, 69% of COD, 76% of HS, 73% of humic acids (HA) and 82% of fulvic acids (FA). In addition, there was a 75% reduction in the absorbance at 254 nm, using 3,000 mg L of coagulant. In the case of the leachate from Gramacho landfill, the treatment removed 91% of color, 69% of TOC, 68% of COD, 77% of HS, 75% of HA and 80% of FA. In addition, there was a 70% reduction in the absorbance at 254 nm using the same concentration of coagulant (3,000 mg L ). The Fenton processes, using FeSO ·7H O and H O in a ratio of 1:5, were also applied to the two leachate samples. In the case of the Gericinó leachate, the Fenton treatment removed 95% of color, 75% of TOC, 68% of COD, 82% of HS, 77% of HA and 93% of FA. In addition, there was a 93% reduction in the absorbance at 254 nm. In the case of the Gramacho leachate, the Fenton treatment removed 93% of color, 73% of TOC, 71% of COD, 81% of HS, 76% of HA, 90% of FA, and there was an 84% reduction in the absorbance at 254 nm. The results of humic substances, color, organic matter and aromatic organic matter (absorbance at 254 nm) demonstrate that the coagulation/flocculation and Fenton processes were efficient in the removal of recalcitrant organic matter from landfill leachates.
[Mh] Termos MeSH primário: Substâncias Húmicas/análise
Peróxido de Hidrogênio/química
Ferro/química
Resíduos Sólidos/análise
Eliminação de Resíduos Líquidos/métodos
Poluentes Químicos da Água/análise
[Mh] Termos MeSH secundário: Benzopiranos/análise
Brasil
Floculação
Eliminação de Resíduos/métodos
Instalações de Eliminação de Resíduos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Fenton's reagent); 0 (Humic Substances); 0 (Solid Waste); 0 (Water Pollutants, Chemical); BBX060AN9V (Hydrogen Peroxide); E1UOL152H7 (Iron); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1080/10934529.2017.1312182


  8 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28886976
[Au] Autor:Wang H; Wang Y; Lou Z; Zhu N; Yuan H
[Ad] Endereço:School of Environmental Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, PR China.
[Ti] Título:The degradation processes of refractory substances in nanofiltration concentrated leachate using micro-ozonation.
[So] Source:Waste Manag;69:274-280, 2017 Nov.
[Is] ISSN:1879-2456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Concentrated leachate (CL) is the byproduct of leachate treated by the membrane separation unit after bio-treatment processes, and contains many humic-like substances. Ozonation processes were applied and optimized for the further removal of those refractory matters in this work. Micro-bubble ozonation (MB-O ) possessed the best performance, and 76.0% and 69.9% of COD and TOC were found to be removed under the optimum conditions with ozone dosage of 2.4g/L, initial pH of 9 and reaction time of 120min. The reaction rate k in MB-O was 0.0104min , three times higher than that in normal O . The percentages of humic acid and fulvic acid in CL decreased from 24.1% to 14.3% and 49.6% to 25.0%, while that of HyI substances increased from 26.3% to 60.7%, which was also found in the fraction of <2000Da, with the occupied percentage increased from 0 to 63.0%. The humic acid-like substances might be transformed to matters with carbonyl and carboxyl group, since a continuous blue-shift was observed from Em/Ex 475/390 to 410/325nm. MB-O could be a promising method for the advanced treatment of CL.
[Mh] Termos MeSH primário: Benzopiranos/química
Filtração/métodos
Substâncias Húmicas
Nanoestruturas/química
Ozônio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Humic Substances); 66H7ZZK23N (Ozone); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170910
[St] Status:MEDLINE


  9 / 8172 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28843845
[Au] Autor:Singh R; Kumar V; Bharate SS; Vishwakarma RA
[Ad] Endereço:Preformulation Laboratory, PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
[Ti] Título:Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.
[So] Source:Bioorg Med Chem;25(20):5513-5521, 2017 Oct 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Bergenin is a unique C-glycoside natural product possessing anti-inflammatory and anti-arthritic activity. It is hydrophilic molecule and stable under acidic conditions however is unstable at neutral-basic pH conditions. The rate of degradation is directly proportional to the increase in pH which might be one of the reasons for its low oral bioavailability. Thus, herein our objective was to improve its stability using prodrug strategy. Various ester and ether prodrugs were synthesized and studied for lipophilicity, chemical stability and enzymatic hydrolysis in plasma/esterase. The stability of synthesized prodrugs was evaluated in buffers at different pH, in biorelevant media such as SGF, SIF, rat plasma and in esterase enzyme. All prodrugs displayed significantly improved lipophilicity compared with bergenin, which was in accordance with the criteria of drug-like compounds. Acetyl ester 4a appeared to be the most promising prodrug as it remained stable at gastric/intestinal pH and was completely transformed to the parent compound bergenin in plasma as desired for an ideal prodrug. The data presented herein, will help in designing stable prodrugs of unstable molecules with desired physicochemical properties in structurally similar chemotypes.
[Mh] Termos MeSH primário: Artrite Reumatoide/tratamento farmacológico
Benzopiranos/farmacologia
Esterases/metabolismo
Pró-Fármacos/farmacologia
Saxifragaceae/química
[Mh] Termos MeSH secundário: Animais
Benzopiranos/síntese química
Benzopiranos/metabolismo
Concentração de Íons de Hidrogênio
Fígado/enzimologia
Conformação Molecular
Pró-Fármacos/síntese química
Pró-Fármacos/metabolismo
Ratos
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Prodrugs); EC 3.1.- (Esterases); L84RBE4IDC (bergenin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170828
[St] Status:MEDLINE


  10 / 8172 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28832651
[Au] Autor:Huang Z; Lu Q; Wang J; Chen X; Mao X; He Z
[Ad] Endereço:College of Natural Resources and Environment, South China Agricultural University, Guangzhou, China.
[Ti] Título:Inhibition of the bioavailability of heavy metals in sewage sludge biochar by adding two stabilizers.
[So] Source:PLoS One;12(8):e0183617, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Agricultural application of sewage sludge (SS) after carbonization is a plausible way for disposal. Despite its benefits of improving soil fertility and C sequestration, heavy metals contained in sewage sludge biochars (SSB) are still a concern. In this study, two types of heavy metal stabilizers were chosen: fulvic acid (FA) and phosphogypsum (with CaSO4, CS, as the main component). The two stabilizers were incorporated into SS prior to 350°C carbonization for 1 h at the rates of 1%, 2%, or 4%. The obtained SSBs were then analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). Total and available concentrations of four heavy metals, i.e., Zn, Pb, Cd, and Ni, in the SSBs were determined. In addition, a series of pot soil culture experiments was conducted to investigate the effects of stabilizers incorporation into SSB on heavy metal bioavailability and the uptake by plants (corn as an indicator) and plant biomass yield, with SS and SSB (no stabilizers) as controls. The results showed that incorporation of both FA and CS increased functional groups such as carboxyl, phenol, hydroxyl, amine and quinine groups in the SSBs. The percentage of heavy metals in sulfuric and oxidizable state and residual state of SSBs were significantly increased after carbonization, and hence the mobility of the heavy metals in SSBs was decreased. The introduction of the stabilizers (i.e., FA or CS) significantly lowered the total and available concentrations of Zn, Pb, Cd, and Ni. The reduction in available heavy metal concentration increased with incorporation rate of the stabilizers from 1% to 4%. In the treatments with FA or CS incorporated SSB, less heavy metals were taken up by plants and more plant biomass yields were obtained. The mitigating effects were more pronounced at higher rates of FA or CS stabilizer. These findings provide a way to lower bioavailability of heavy metals in SS or SSB for land application or horticulture as a peat substitute.
[Mh] Termos MeSH primário: Benzopiranos/química
Sulfato de Cálcio/química
Carvão Vegetal
Metais Pesados/farmacocinética
Fósforo/química
Esgotos
[Mh] Termos MeSH secundário: Disponibilidade Biológica
Metais Pesados/química
Espectroscopia Fotoeletrônica
Plantas/metabolismo
Espectroscopia de Infravermelho com Transformada de Fourier
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Metals, Heavy); 0 (Sewage); 0 (biochar); 13397-24-5 (phosphogypsum); 16291-96-6 (Charcoal); 27YLU75U4W (Phosphorus); WAT0DDB505 (Calcium Sulfate); XII14C5FXV (fulvic acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170824
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183617



página 1 de 818 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde