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[PMID]: 29338026 [Au] Autor: Vanzyl EJ; Rick KRC; Blackmore AB; MacFarlane EM; McKay BC [Ad] Endereço: Department of Biology, Carleton University, Ottawa ON, Canada. [Ti] Título: Flow cytometric analysis identifies changes in S and M phases as novel cell cycle alterations induced by the splicing inhibitor isoginkgetin. [So] Source: PLoS One;13(1):e0191178, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The spliceosome is a large ribonucleoprotein complex that catalyzes the removal of introns from RNA polymerase II-transcribed RNAs. Spliceosome assembly occurs in a stepwise manner through specific intermediates referred to as pre-spliceosome complexes E, A, B, B* and C. It has been reported that small molecule inhibitors of the spliceosome that target the SF3B1 protein component of complex A lead to the accumulation of cells in the G1 and G2/M phases of the cell cycle. Here we performed a comprehensive flow cytometry analysis of the effects of isoginkgetin (IGG), a natural compound that interferes with spliceosome assembly at a later step, complex B formation. We found that IGG slowed cell cycle progression in multiple phases of the cell cycle (G1, S and G2) but not M phase. This pattern was somewhat similar to but distinguishable from changes associated with an SF3B1 inhibitor, pladienolide B (PB). Both drugs led to a significant decrease in nascent DNA synthesis in S phase, indicative of an S phase arrest. However, IGG led to a much more prominent S phase arrest than PB while PB exhibited a more pronounced G1 arrest that decreased the proportion of cells in S phase as well. We also found that both drugs led to a comparable decrease in the proportion of cells in M phase. This work indicates that spliceosome inhibitors affect multiple phases of the cell cycle and that some of these effects vary in an agent-specific manner despite the fact that they target splicing at similar stages of spliceosome assembly. [Mh] Termos MeSH primário: Biflavonoides/farmacologia Divisão Celular/efeitos dos fármacos Processamento de RNA/efeitos dos fármacos Fase S/efeitos dos fármacos [Mh] Termos MeSH secundário: Ciclo Celular/efeitos dos fármacos Pontos de Checagem do Ciclo Celular/efeitos dos fármacos Replicação do DNA/efeitos dos fármacos Compostos de Epóxi/farmacologia Citometria de Fluxo Células HCT116 Seres Humanos Macrolídeos/farmacologia Precursores de RNA/metabolismo Spliceossomos/efeitos dos fármacos Spliceossomos/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Biflavonoids); 0 (Epoxy Compounds); 0 (Macrolides); 0 (RNA Precursors); 0 (isoginkgetin); 0 (pladienolide B) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180117 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191178

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[PMID]: 29313327 [Au] Autor: Chai WM; Huang Q; Lin MZ; Ou-Yang C; Huang WY; Wang YX; Xu KL; Feng HL [Ad] Endereço: College of Life Science and Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University , Nanchang, Jiangxi 330022, People's Republic of China. [Ti] Título: Condensed Tannins from Longan Bark as Inhibitor of Tyrosinase: Structure, Activity, and Mechanism. [So] Source: J Agric Food Chem;66(4):908-917, 2018 Jan 31. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In this study, the content, structure, antityrosinase activity, and mechanism of longan bark condensed tannins were evaluated. The findings obtained from mass spectrometry demonstrated that longan bark condensed tannins were mixtures of procyanidins, propelargonidins, prodelphinidins, and their acyl derivatives (galloyl and p-hydroxybenzoate). The enzyme analysis indicated that these mixtures were efficient, reversible, and mixed (competitive is dominant) inhibitor of tyrosinase. What's more, the mixtures showed good inhibitions on proliferation, intracellular enzyme activity and melanogenesis of mouse melanoma cells (B ). From molecular docking, the results showed the interactions between inhibitors and tyrosinase were driven by hydrogen bond, electrostatic, and hydrophobic interactions. In addition, high levels of total phenolic and extractable condensed tannins suggested that longan bark might be a good source of tyrosinase inhibitor. This study would offer theoretical basis for the development of longan bark condensed tannins as novel food preservatives and medicines of skin diseases. [Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia Monofenol Mono-Oxigenase/antagonistas & inibidores Casca de Planta/química Sapindaceae/química Taninos/química Taninos/farmacologia [Mh] Termos MeSH secundário: Animais Antocianinas/farmacologia Biflavonoides/farmacologia Catequina/farmacologia Proliferação Celular/efeitos dos fármacos Ligações de Hidrogênio Interações Hidrofóbicas e Hidrofílicas Espectrometria de Massas Melaninas/análise Melaninas/antagonistas & inibidores Melaninas/biossíntese Melanoma Experimental Camundongos Modelos Moleculares Simulação de Acoplamento Molecular Oxirredutases Parabenos/farmacologia Proantocianidinas/farmacologia Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz Eletricidade Estática Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anthocyanins); 0 (Biflavonoids); 0 (Enzyme Inhibitors); 0 (Melanins); 0 (Parabens); 0 (Proanthocyanidins); 0 (Tannins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); EC 1.- (Oxidoreductases); EC 1.14.18.- (monophenolase); EC 1.14.18.1 (Monophenol Monooxygenase); EM6MD4AEHE (delphinidin); JG8Z55Y12H (4-hydroxybenzoic acid) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180212 [Lr] Data última revisão: 180212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180110 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b05481

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[PMID]: 28942285 [Au] Autor: Liu H; Yue Q; He S [Ad] Endereço: Department of Gynaecology, Luoyang Central Hospital, Zhengzhou University, China. [Ti] Título: Amentoflavone suppresses tumor growth in ovarian cancer by modulating Skp2. [So] Source: Life Sci;189:96-105, 2017 Nov 15. [Is] ISSN: 1879-0631 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: AIM: Ovarian cancer is one of most common malignancies in women and is associated with high reoccurrence rate and poor prognosis. This study is designed to investigate the anti-tumor effects of amentoflavone (AF), one of the major active ingredients of S. tamariscina, against ovarian cancer. MATERIALS AND METHODS: Human ovarian cancer cell lines SKOV3 and OVCAR-3 were used in this study. The effect of AF on cell viability was examined by CCK-8 assay. Cell apoptosis and cell cycle distribution was determined by flow cytometry. ROS generation was detected using fluorescent staining. Expression of signaling molecules was determined by western blots. Xenograft model was established to evaluate the therapeutic efficacy of AF in vivo. KEY FINDINGS: Our results showed that AF could significantly suppress cell proliferation, induce apoptosis and block cell cycle progression. Mechanistically, downregulation of S-phase kinase protein 2 (Skp2) by AF contributed to its anti-tumor effect against ovarian cancer. Furthermore, our results showed that AF repressed the expression of Skp2 through ROS/AMPK/mTOR signaling. The anti-tumor effect of AF against ovarian cancer was also confirmed in a xenograft animal model. SIGNIFICANCE: Overall, our present findings highlighted the potential of AF in the treatment of ovarian cancer. Moreover, our study also provided a new elucidation regarding the anti-tumor mechanisms of AF. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia Biflavonoides/farmacologia Neoplasias Ovarianas/tratamento farmacológico Proteínas Quinases Associadas a Fase S/genética [Mh] Termos MeSH secundário: Animais Antineoplásicos Fitogênicos/isolamento & purificação Apoptose/efeitos dos fármacos Biflavonoides/isolamento & purificação Linhagem Celular Tumoral Proliferação Celular/efeitos dos fármacos Sobrevivência Celular/efeitos dos fármacos Regulação para Baixo/efeitos dos fármacos Feminino Seres Humanos Masculino Camundongos Camundongos Endogâmicos BALB C Camundongos Nus Neoplasias Ovarianas/genética Neoplasias Ovarianas/patologia Selaginellaceae/química Ensaios Antitumorais Modelo de Xenoenxerto [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); 0 (Biflavonoids); 0 (S-Phase Kinase-Associated Proteins); 9I1VC79L77 (amentoflavone) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171023 [Lr] Data última revisão: 171023 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170925 [St] Status: MEDLINE

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[PMID]: 28870912 [Au] Autor: Pan PJ; Tsai JJ; Liu YC [Ad] Endereço: Department of Physical Medicine and Rehabilitation, National Yang-Ming University Hospital, Yilan, Taiwan, R.O.C. [Ti] Título: Amentoflavone Inhibits Metastatic Potential Through Suppression of ERK/NF-κB Activation in Osteosarcoma U2OS Cells. [So] Source: Anticancer Res;37(9):4911-4918, 2017 09. [Is] ISSN: 1791-7530 [Cp] País de publicação: Greece [La] Idioma: eng [Ab] Resumo: AIM: The study goal was to investigate effect of amentoflavone on nuclear factor-κB (NF-κB)-modulated metastatic mechanism in osteosarcoma U2OS cells. U2OS cells were treated with amentoflavone, NF-κB inhibitor, protein kinase B (PKB or AKT) inhibitor or mitogen-activated protein kinase (MAPK) inhibitor. Change of cell viability, NF-κB activation, expression of metastasis-associated proteins, signal transduction, and cell migration and invasion were evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, NF-κB reporter gene assay, western blotting, and cell migration and invasion assays. The results demonstrated that inhibition of activation of extracellular signal-regulated kinases (ERK) was a key point for suppression of NF-κB-modulated metastatic mechanism. Amentoflavone significantly inhibited NF-κB activation, ERK phosphorylation, expression of metastasis-associated proteins, and cell migration and invasion. Our findings indicate that amentoflavone reduces metastatic potential through suppression of ERK and NF-κB activation in osteosarcoma U2OS cells. [Mh] Termos MeSH primário: Biflavonoides/farmacologia Neoplasias Ósseas/tratamento farmacológico Movimento Celular/efeitos dos fármacos Inibidores do Citocromo P-450 CYP2C9/farmacologia MAP Quinases Reguladas por Sinal Extracelular/antagonistas & inibidores NF-kappa B/antagonistas & inibidores Osteossarcoma/tratamento farmacológico [Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos Neoplasias Ósseas/metabolismo Neoplasias Ósseas/patologia Proliferação Celular/efeitos dos fármacos MAP Quinases Reguladas por Sinal Extracelular/metabolismo Seres Humanos NF-kappa B/metabolismo Osteossarcoma/metabolismo Osteossarcoma/secundário Fosforilação/efeitos dos fármacos Transdução de Sinais/efeitos dos fármacos Células Tumorais Cultivadas [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Cytochrome P-450 CYP2C9 Inhibitors); 0 (NF-kappa B); 9I1VC79L77 (amentoflavone); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171025 [Lr] Data última revisão: 171025 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170906 [St] Status: MEDLINE

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[PMID]: 28844677 [Au] Autor: Wang W; Chen R; Wang J [Ad] Endereço: Department of Emergency, People's Hospital of Tiantai, Tiantai, PR China; Department of General Practice, People's Hospital of Tiantai, Tiantai, PR China; Department of Hepatopancreatic and Microinvasive Surgery, Zhejiang Provincial People's Hospital, Hangzhou, PR China. Electronic address: wangwei0435a@126.com. [Ti] Título: Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis in rats via anti-inflammatory and activation of the Nrf2 pathway. [So] Source: Biochem Biophys Res Commun;493(1):794-799, 2017 Nov 04. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Prostatitis is one of the most prevalent problems in andriatry and urinary surgery. In the present study, we evaluated the effect of procyanidin B2 (PB) on carrageenan-induced chronic nonbacterial prostatitis in rats. Results showed that PB significantly decreased the prostatic index and enhanced the body weight inhibited by carrageenan. Biochemical results revealed that PB significantly lowered the prostatic specific antigen (PSA) and alleviated oxidative stress in serum. The levels of TNF-α, IL-6, and IL-10 in prostatic homogenate were also significantly decreased after PB treatment. We also found evidence that PB treatment reversed the suppression of Nrf2 nuclear translocation, and increased the expressions of NQO1 and HO-1 in the prostate glands. In conclusion, treatment with PB attenuates carrageenan-induced chronic nonbacterial prostatitis via anti-inflammatory and activation of the Nrf2 pathway. [Mh] Termos MeSH primário: Biflavonoides/administração & dosagem Catequina/administração & dosagem Citocinas/imunologia Fator 2 Relacionado a NF-E2/imunologia Proantocianidinas/administração & dosagem Prostatite/imunologia Transdução de Sinais/imunologia [Mh] Termos MeSH secundário: Animais Anti-Inflamatórios/administração & dosagem Infecções Bacterianas/induzido quimicamente Infecções Bacterianas/patologia Carragenina Relação Dose-Resposta a Droga Regulação da Expressão Gênica/imunologia Fatores Imunológicos/imunologia Masculino Prostatite/induzido quimicamente Prostatite/patologia Ratos Ratos Sprague-Dawley Transdução de Sinais/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Biflavonoids); 0 (Cytokines); 0 (Immunologic Factors); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, rat); 0 (Proanthocyanidins); 29106-49-8 (procyanidin B2); 8R1V1STN48 (Catechin); 9000-07-1 (Carrageenan) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171016 [Lr] Data última revisão: 171016 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170829 [St] Status: MEDLINE

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[PMID]: 28783339 [Au] Autor: Waterman MJ; Nugraha AS; Hendra R; Ball GE; Robinson SA; Keller PA [Ti] Título: Antarctic Moss Biflavonoids Show High Antioxidant and Ultraviolet-Screening Activity. [So] Source: J Nat Prod;80(8):2224-2231, 2017 Aug 25. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Ceratodon purpureus is a cosmopolitan moss that survives some of the harshest places on Earth: from frozen Antarctica to hot South Australian deserts. In a study on the survival mechanisms of the species, nine compounds were isolated from Australian and Antarctic C. purpureus. This included five biflavonoids, with complete structural elucidation of 1 and 2 reported here for the first time, as well as an additional four known phenolic compounds. Dispersion-corrected DFT calculations suggested a rotational barrier, leading to atropisomerism, resulting in the presence of diastereomers for compound 2. All isolates absorbed strongly in the ultraviolet (UV) spectrum, e.g., biflavone 1 (UV-A, 315-400 nm), which displayed the strongest radical-scavenging activity, 13% more efficient than the standard rutin; p-coumaric acid and trans-ferulic acid showed the highest UV-B (280-315 nm) absorption. The more complex and abundant 1 and 2 presumably have dual roles as both UV-screening and antioxidant compounds. They are strongly bound to Antarctic moss cell walls as well as located inside the cells of moss from both locations. The combined high stability and photoprotective abilities of these isolates may account for the known resilience of this species to UV-B radiation and its survival in some of the toughest locations in the world. [Mh] Termos MeSH primário: Antioxidantes/farmacologia Biflavonoides/isolamento & purificação Biflavonoides/farmacologia Briófitas/química Bryopsida/química Ácidos Cumáricos/química Fenóis/sangue [Mh] Termos MeSH secundário: Regiões Antárticas Antioxidantes/química Austrália Biflavonoides/química Estrutura Molecular Propionatos Raios Ultravioleta [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Biflavonoids); 0 (Coumaric Acids); 0 (Phenols); 0 (Propionates); AVM951ZWST (ferulic acid); IBS9D1EU3J (trans-3-(4'-hydroxyphenyl)-2-propenoic acid) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170808 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.7b00085

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[PMID]: 28780322 [Au] Autor: Niu L; Shao M; Liu Y; Hu J; Li R; Xie H; Zhou L; Shi L; Zhang R; Niu Y [Ad] Endereço: Department of Toxicology, Hebei Medical University, Shijiazhuang, China; Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Jiankang Road 12, Shijiazhuang, 050011 Hebei, China. [Ti] Título: Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice. [So] Source: Chem Biol Interact;275:133-144, 2017 Sep 25. [Is] ISSN: 1872-7786 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: Titanium dioxide nanoparticles (TiO NPs) are widely used to additives in cosmetics, pharmaceuticals, paints and foods. Recent studies have demonstrated that TiO NPs increased the risk of cancer and the mechanism might relate with oxidative stress. Grape seed procyanidin extract (GSPE) is a natural compound which has been demonstrated to possess a wide array of pharmacological and biochemical actions, including anti-inflammatory, anti-carcinogenic, and antioxidant properties. Our data show that GSPE prevents the changes of histopathology and biomarkers in heart, liver and kidney that occur in mice exposed to TiO NPs. After pretreatment with GSPE, the DNA damage, reactive oxygen species (ROS) generation and malondialdehyde (MDA) content in mice exposed to TiO NPs had statistically significant decreases in dose dependent manners. GSPE increased the expression of nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), NAD(P)H dehydrogenase[quinine] 1(NQO1), heme oxygenase 1 (HO-1) and glutamate-cysteine ligase catalytic subunit (GCLC). We conclude that grape seed procyanidin extract prevents the majority of tissue and molecular damage resulting from nanoparticle treatment. The protective effect of GSPE may be due to its strong antioxidative activities which related with the activated Nrf2 and its down-regulated genes including NQO1, HO-1 and GCLC. [Mh] Termos MeSH primário: Suplementos Nutricionais Extrato de Sementes de Uva Nanopartículas Metálicas/toxicidade Fator 2 Relacionado a NF-E2/metabolismo Estresse Oxidativo/efeitos dos fármacos Estresse Oxidativo/fisiologia Titânio/química [Mh] Termos MeSH secundário: Animais Biflavonoides/química Biflavonoides/isolamento & purificação Biflavonoides/farmacologia Catequina/química Catequina/isolamento & purificação Catequina/farmacologia Dano ao DNA/efeitos dos fármacos Regulação para Baixo/efeitos dos fármacos Glutamato-Cisteína Ligase/metabolismo Extrato de Sementes de Uva/química Heme Oxigenase-1/metabolismo Rim/efeitos dos fármacos Rim/metabolismo Rim/patologia Fígado/efeitos dos fármacos Fígado/metabolismo Fígado/patologia Malondialdeído/metabolismo Nanopartículas Metálicas/química Camundongos NAD(P)H Desidrogenase (Quinona)/metabolismo Proantocianidinas/química Proantocianidinas/isolamento & purificação Proantocianidinas/farmacologia Espécies Reativas de Oxigênio/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Grape Seed Extract); 0 (NF-E2-Related Factor 2); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 15FIX9V2JP (titanium dioxide); 4852-22-6 (procyanidin); 4Y8F71G49Q (Malondialdehyde); 8R1V1STN48 (Catechin); D1JT611TNE (Titanium); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone)); EC 1.6.5.2 (Nqo1 protein, mouse); EC 6.3.2.2 (Glutamate-Cysteine Ligase) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170807 [St] Status: MEDLINE

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[PMID]: 28711497 [Au] Autor: Ilacqua AN; Shettler JA; Wernke KM; Skalla JK; McQuade KJ [Ad] Endereço: Department of Biological Sciences, Colorado Mesa University, Grand Junction, CO 81501, USA. [Ti] Título: Theaflavins from black tea affect growth, development, and motility in Dictyostelium discoideum. [So] Source: Biochem Biophys Res Commun;491(2):449-454, 2017 Sep 16. [Is] ISSN: 1090-2104 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Theaflavins, flavonoids found in black tea, exhibit a variety of health-promoting activities, but the mechanisms by which they act are not clear. Here, we assess the effects of black tea extract and isolated theaflavins on Dictyostelium discoideum, a model organism exhibiting an unusual life cycle relying on conserved pathways involved in human disease. Dictyostelium has been used to characterize the activities of numerous bioactive small molecules, including catechins, from which theaflavins are produced during the preparation of black tea. We show that theaflavins block growth, development, and motility in Dictyostelium, results that suggest catechins and theaflavins exert similar activities in this organism. [Mh] Termos MeSH primário: Biflavonoides/farmacologia Camellia sinensis/química Catequina/farmacologia Catecóis/farmacologia Dictyostelium/efeitos dos fármacos [Mh] Termos MeSH secundário: Cultura Axênica Biflavonoides/química Biflavonoides/isolamento & purificação Catequina/química Catequina/isolamento & purificação Catecóis/química Catecóis/isolamento & purificação Movimento Celular/efeitos dos fármacos Movimento Celular/fisiologia Dictyostelium/crescimento & desenvolvimento Extratos Vegetais/química Relação Estrutura-Atividade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Catechols); 0 (Plant Extracts); 1IA46M0D13 (theaflavin); 8R1V1STN48 (Catechin) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170829 [Lr] Data última revisão: 170829 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170717 [St] Status: MEDLINE

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[PMID]: 28677264 [Au] Autor: Wu QJ; Wang YQ; Qi YX [Ad] Endereço: College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China. [Ti] Título: Influence of procyanidin supplementation on the immune responses of broilers challenged with lipopolysaccharide. [So] Source: Anim Sci J;88(7):983-990, 2017 Jul. [Is] ISSN: 1740-0929 [Cp] País de publicação: Australia [La] Idioma: eng [Ab] Resumo: In the present study, the effect of dietary procyanidin (PCA, from pine needles) supplementation on the innate immunity of broilers were investigated. The experiment was designed as a 2 × 4 factorial arrangement (eight cages / treatment; six birds (one-day-old) / cage) with dietary PCA concentrations (0, 0.05, 0.075 and 0.1%) and two immune treatments (injection of lipopolysaccharide (LPS) (0.5 mg/kg body weight) or saline). LPS was dissolved in sterile 9 g/L (w/v) NaCl solution at 16, 18, 20 days of age to mimic immune stress. The remaining birds were injected with saline as a placebo. The results indicated that, prior to LPS challenge, the PCA diet had no significant effect on bird growth performance. The injection of LPS was also not associated with any significant changes in poultry performance. LPS injection increased the activity of nitrogen oxides (NOx) and the concentrations of inflammatory cytokines (interferon-γ (IFN-γ), interleukin-1ß (IL-1ß), IL-2, IL-4, IL-6 and IL-10) in serum; dietary PCA decreased these concentrations (P < 0.05) in the PCA 0.1% group, further illustrating the immune effect of PCA. In conclusion, PCA supplementation has a beneficial effect on LPS challenge, which may be associated with the inhibition of the secretion of cytokines and decrease in the proinflammatory marker NOx. [Mh] Termos MeSH primário: Ração Animal Biflavonoides/farmacologia Catequina/farmacologia Galinhas/imunologia Dieta/veterinária Suplementos Nutricionais Imunidade Inata/efeitos dos fármacos Lipopolissacarídeos/imunologia Proantocianidinas/farmacologia [Mh] Termos MeSH secundário: Animais Biflavonoides/administração & dosagem Catequina/administração & dosagem Citocinas/sangue Mediadores da Inflamação/sangue Mediadores da Inflamação/metabolismo Óxidos de Nitrogênio/metabolismo Pinus/química Proantocianidinas/administração & dosagem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Nitrogen Oxides); 0 (Proanthocyanidins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170921 [Lr] Data última revisão: 170921 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170706 [St] Status: MEDLINE [do] DOI: 10.1111/asj.12729

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[PMID]: 28595385 [Au] Autor: Pereira-Caro G; Moreno-Rojas JM; Brindani N; Del Rio D; Lean MEJ; Hara Y; Crozier A [Ad] Endereço: Department of Food and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) , Avenida Menendez-Pidal, SN 14004, Córdoba, Spain. [Ti] Título: Bioavailability of Black Tea Theaflavins: Absorption, Metabolism, and Colonic Catabolism. [So] Source: J Agric Food Chem;65(26):5365-5374, 2017 Jul 05. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Data obtained with in vitro fecal incubations and a feeding study indicate black tea theaflavin and its galloyl derivatives are not absorbed in detectable amounts in either the upper or lower gastrointestinal tract. The theaflavin skeleton is comparatively resistant to degradation by colonic bacteria with a 67% recovery being obtained after a 24 h incubation, which yielded 21 phenolic and aromatic catabolites. The theaflavin galloyl moiety was removed by the microbiota, and the released gallic acid further transformed to 3-O- and 4-O-methyl gallic acids, pyrogallol-1-sulfate and pyrogallol-2-sulfate, which were excreted in urine in amounts equivalent to 94% of intake. The main urinary product potentially derived from breakdown of the theaflavin skeleton was 3-(4'-hydroxyphenyl)propionic acid. A number of the colonic catabolites originating from gallic acid and theaflavins has been reported to be bioactive in ex vivo and in vitro models with a variety of potential modes of action. [Mh] Termos MeSH primário: Biflavonoides/metabolismo Catequina/metabolismo Colo/metabolismo Chá/metabolismo [Mh] Termos MeSH secundário: Adulto Bactérias/isolamento & purificação Bactérias/metabolismo Biflavonoides/química Disponibilidade Biológica Camellia sinensis/química Camellia sinensis/metabolismo Catequina/química Colo/microbiologia Fezes/química Fezes/microbiologia Feminino Microbioma Gastrointestinal Seres Humanos Masculino Chá/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biflavonoids); 0 (Tea); 1IA46M0D13 (theaflavin); 8R1V1STN48 (Catechin) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170721 [Lr] Data última revisão: 170721 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170610 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b01707

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