[PMID]: | 29313327 |
[Au] Autor: | Chai WM; Huang Q; Lin MZ; Ou-Yang C; Huang WY; Wang YX; Xu KL; Feng HL |
[Ad] Endereço: | College of Life Science and Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University , Nanchang, Jiangxi 330022, People's Republic of China. |
[Ti] Título: | Condensed Tannins from Longan Bark as Inhibitor of Tyrosinase: Structure, Activity, and Mechanism. |
[So] Source: | J Agric Food Chem;66(4):908-917, 2018 Jan 31. |
[Is] ISSN: | 1520-5118 |
[Cp] País de publicação: | United States |
[La] Idioma: | eng |
[Ab] Resumo: | In this study, the content, structure, antityrosinase activity, and mechanism of longan bark condensed tannins were evaluated. The findings obtained from mass spectrometry demonstrated that longan bark condensed tannins were mixtures of procyanidins, propelargonidins, prodelphinidins, and their acyl derivatives (galloyl and p-hydroxybenzoate). The enzyme analysis indicated that these mixtures were efficient, reversible, and mixed (competitive is dominant) inhibitor of tyrosinase. What's more, the mixtures showed good inhibitions on proliferation, intracellular enzyme activity and melanogenesis of mouse melanoma cells (B ). From molecular docking, the results showed the interactions between inhibitors and tyrosinase were driven by hydrogen bond, electrostatic, and hydrophobic interactions. In addition, high levels of total phenolic and extractable condensed tannins suggested that longan bark might be a good source of tyrosinase inhibitor. This study would offer theoretical basis for the development of longan bark condensed tannins as novel food preservatives and medicines of skin diseases. |
[Mh] Termos MeSH primário: |
Inibidores Enzimáticos/farmacologia Monofenol Mono-Oxigenase/antagonistas & inibidores Casca de Planta/química Sapindaceae/química Taninos/química Taninos/farmacologia
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[Mh] Termos MeSH secundário: |
Animais Antocianinas/farmacologia Biflavonoides/farmacologia Catequina/farmacologia Proliferação Celular/efeitos dos fármacos Ligações de Hidrogênio Interações Hidrofóbicas e Hidrofílicas Espectrometria de Massas Melaninas/análise Melaninas/antagonistas & inibidores Melaninas/biossíntese Melanoma Experimental Camundongos Modelos Moleculares Simulação de Acoplamento Molecular Oxirredutases Parabenos/farmacologia Proantocianidinas/farmacologia Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz Eletricidade Estática Relação Estrutura-Atividade
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Anthocyanins); 0 (Biflavonoids); 0 (Enzyme Inhibitors); 0 (Melanins); 0 (Parabens); 0 (Proanthocyanidins); 0 (Tannins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); EC 1.- (Oxidoreductases); EC 1.14.18.- (monophenolase); EC 1.14.18.1 (Monophenol Monooxygenase); EM6MD4AEHE (delphinidin); JG8Z55Y12H (4-hydroxybenzoic acid) |
[Em] Mês de entrada: | 1802 |
[Cu] Atualização por classe: | 180212 |
[Lr] Data última revisão:
| 180212 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 180110 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1021/acs.jafc.7b05481 |
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