| [PMID]: | 28747329 |
| [Au] Autor: | Pereira-Caro G; Polyviou T; Ludwig IA; Nastase AM; Moreno-Rojas JM; Garcia AL; Malkova D; Crozier A |
| [Ad] Endereço: | Department of Food and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA)-Alameda del Obispo, Cordoba, Spain. |
| [Ti] Título: | Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes. |
| [So] Source: | Am J Clin Nutr;106(3):791-800, 2017 Sep. |
| [Is] ISSN: | 1938-3207 |
| [Cp] País de publicação: | United States |
| [La] Idioma: | eng |
| [Ab] Resumo: | Physical exercise has been reported to increase the bioavailability of citrus flavanones. We investigated the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained males before and after cessation of training for 7 d. Ten fit, endurance-trained males, with a mean ± SD maximal oxygen consumption of 58.2 ± 5.3 mL · kg · min , followed a low (poly)phenol diet for 2 d before drinking 500 mL of OJ containing 398 µmol of (poly)phenols, of which 330 µmol was flavanones. After the volunteers stopped training for 7 d the feeding study was repeated. Urine samples were collected 12 h pre- and 24 h post-OJ consumption. Bioavailability was assessed by the quantitative analysis of urinary flavanone metabolites and (poly)phenol catabolites with the use of high-pressure liquid chromatography-high resolution mass spectrometry. During training, 0-24-h urinary excretion of flavanone metabolites, mainly hesperetin-3'- -glucuronide, hesperetin-3'-sulfate, naringenin-4'- -glucuronide, naringenin-7- -glucuronide, was equivalent to 4.2% of OJ flavanone intake. This increased significantly to 5.2% when OJ was consumed after the volunteers stopped training for 7 d. Overall, this trend, although not significant, was also observed with OJ-derived colonic catabolites, which, after supplementation in the trained state, were excreted in amounts equivalent to 51% of intake compared with 59% after cessation of training. However, urinary excretion of 3 colonic catabolites of bacterial origin, most notably, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid, did increase significantly when OJ was consumed postcessation compared with precessation of training. Data were also obtained on interindividual variations in flavanone bioavailability. A 7-d cessation of endurance training enhanced, rather than reduced, the bioavailability of OJ flavanones. The biological significance of these differences and whether they extend to the bioavailability of other dietary (poly)phenols remain to be determined. Hesperetin-3'- -glucuronide and the colonic microbiota-derived catabolite 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid are key biomarkers of the consumption of hesperetin- -glycoside-containing OJ and other citrus products. This trial was registered at clinicaltrials.gov as NCT02627547. |
| [Mh] Termos MeSH primário: |
Citrus sinensis/química
Exercício/fisiologia
Flavanonas/farmacocinética
Resistência Física/fisiologia
Extratos Vegetais/farmacocinética
Polifenóis/farmacocinética
Descanso/fisiologia
|
| [Mh] Termos MeSH secundário: |
Atletas
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Colo/metabolismo
Dieta
Flavanonas/urina
Frutas
Sucos de Frutas e Vegetais
Glucuronídeos/urina
Hesperidina/farmacocinética
Seres Humanos
Masculino
Espectrometria de Massas
Consumo de Oxigênio
Polifenóis/urina
Esportes/fisiologia
|
| [Pt] Tipo de publicação: | CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE |
[Nm] Nome de substância:
| 0 (Flavanones); 0 (Glucuronides); 0 (Plant Extracts); 0 (Polyphenols); E750O06Y6O (Hesperidin); HN5425SBF2 (naringenin); Q9Q3D557F1 (hesperetin) |
| [Em] Mês de entrada: | 1709 |
| [Cu] Atualização por classe: | 180124 |
[Lr] Data última revisão:
| 180124 |
| [Sb] Subgrupo de revista: | AIM; IM |
| [Da] Data de entrada para processamento: | 170728 |
| [Cl] Clinical Trial: | ClinicalTrial
|
| [St] Status: | MEDLINE |
| [do] DOI: | 10.3945/ajcn.116.149898 |
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