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[PMID]:28453191
[Au] Autor:Wang K; Chen Z; Huang J; Huang L; Luo N; Liang X; Liang M; Xie W
[Ad] Endereço:Southern Medical University, Guangzhou, China.
[Ti] Título:Naringenin prevents ischaemic stroke damage via anti-apoptotic and anti-oxidant effects.
[So] Source:Clin Exp Pharmacol Physiol;44(8):862-871, 2017 Aug.
[Is] ISSN:1440-1681
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Apoptosis and oxidative stress are considered to be the major factors associated with the development and progression of many ischaemic cerebrovascular diseases. Naringenin (NAR) is an abundant flavanone in citrus plants and has been found to exhibit anti-oxidant, anti-carcinogenic and anti-apoptotic effects. This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischaemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signalling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) model was prepared and neurological defects and the brain wet/dry (W/D) ratio were assessed and recorded; apoptosis was measured based on the TUNEL assay. Additionally, biochemical indices were detected both in vitro and in vivo. NAR promoted cortical neuron cell proliferation, inhibited apoptosis and oxidative stress, and regulated the localization of Nrf2 protein (P<.05). Furthermore, silencing and overexpression of Nrf2 affected cortical neuron cell proliferation and apoptosis (P<.05). In vivo, NAR could alleviate cerebral oedema, improve neurological defects, and reduce apoptosis and oxidative stress (P<.05). These findings demonstrated that NAR could reduce apoptosis and oxidative stress and that Nrf2 signalling pathway is involved in this regulatory process. NAR has health-promoting properties because of its anti-apoptotic and anti-oxidant effects in cases of ischaemic stroke.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Flavanonas/farmacologia
Infarto da Artéria Cerebral Média/complicações
Acidente Vascular Cerebral/complicações
Acidente Vascular Cerebral/patologia
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular/efeitos dos fármacos
Animais
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/metabolismo
Proliferação Celular/efeitos dos fármacos
Citoproteção/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Neurônios/efeitos dos fármacos
Neurônios/patologia
Estresse Oxidativo/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Acidente Vascular Cerebral/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavanones); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, rat); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/1440-1681.12775


  2 / 3751 MEDLINE  
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[PMID]:28749656
[Au] Autor:Jang S; Jang S; Xiu Y; Kang TJ; Lee SH; Koffas MAG; Jung GY
[Ad] Endereço:Department of Chemical Engineering, Pohang University of Science and Technology , 77 Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 37673, Korea.
[Ti] Título:Development of Artificial Riboswitches for Monitoring of Naringenin In Vivo.
[So] Source:ACS Synth Biol;6(11):2077-2085, 2017 Nov 17.
[Is] ISSN:2161-5063
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Microbial strains are considered promising hosts for production of flavonoids because of their rapid growth rate and suitability for large-scale manufacturing. However, productivity and titer of current recombinant strains still do not meet the requirements of industrial processes. Genetically encoded biosensors have been applied for high-throughput screening or dynamic regulation of biosynthetic pathways for enhancing the performance of microbial strains that produce valuable chemicals. Currently, few protein sensor-regulators for flavonoids exist. Unlike the protein-based trans-regulating controllers, riboswitches can respond to their ligands faster and eliminate off-target effects. Here, we developed artificial riboswitches that activate gene expression in response to naringenin, an important flavonoid. RNA aptamers for naringenin were developed using SELEX and cloned upstream of a dual selectable marker gene to construct a riboswitch library. Two in vivo selection routes were applied separately to the library by supplementing naringenin at two different concentrations during enrichments to modulate the operational ranges of the riboswitches. The selected riboswitches were responsive to naringenin and activated gene expression up to 2.91-fold. Operational ranges of the riboswitches were distinguished on the basis of their selection route. Additionally, the specificity of the riboswitches was assessed, and their applicability as dynamic regulators was confirmed. Collectively, the naringenin riboswitches reported in this work will be valuable tools in metabolic engineering of microorganisms for the production of flavonoids.
[Mh] Termos MeSH primário: Técnicas Biossensoriais/métodos
Escherichia coli
Flavanonas
Regulação Bacteriana da Expressão Gênica/efeitos dos fármacos
Riboswitch
Técnica de Seleção de Aptâmeros
[Mh] Termos MeSH secundário: Escherichia coli/genética
Escherichia coli/metabolismo
Flavanonas/análise
Flavanonas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavanones); 0 (Riboswitch); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1021/acssynbio.7b00128


  3 / 3751 MEDLINE  
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[PMID]:29287782
[Au] Autor:Liaquat L; Batool Z; Sadir S; Rafiq S; Shahzad S; Perveen T; Haider S
[Ad] Endereço:Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.
[Ti] Título:Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats.
[So] Source:Life Sci;194:213-223, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress. For this purpose, young rats were orally treated with naringenin (NAR), curcumin (CUR) and quercetin (QUE) at a dose of 50mg/kg, 200mg/kg and 50mg/kg respectively for 16days. At 4th day of drug administration cognitive functions were monitored by Morris water maze (MWM) test. In MWM cognitive functions in terms of learning acquisition (1h after training), retention (24h after training), memory extinction (4days after training), and reconsolidation (8 and 12days after training) were monitored. Biochemical and neurochemical analysis were done in whole brain. KEY FINDINGS: Treatment of NAR, CUR and QUE significantly enhanced learning acquisition, memory retention and reconsolidation and prevented memory extinction. Treatment of NAR and QUE prevented the alteration of brain antioxidant defence system by enhancing antioxidant enzyme activities and increasing antioxidant compound concentration. Oxidative stress in terms of lipid peroxidation was significantly prevented in treated rats. Serotonergic and cholinergic improvement was also found in treated rats. SIGNIFICANCE: The present study therefore provides biological evidence supporting the usefulness of these polyphenolic compounds in daily life for improvement of cognitive abilities and hence may have a potential role in the management of dementia and related disorders.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Cognição/efeitos dos fármacos
Curcumina/farmacologia
Flavanonas/farmacologia
Memória/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Acetilcolinesterase/metabolismo
Animais
Antioxidantes/administração & dosagem
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Colinérgicos/farmacologia
Curcumina/administração & dosagem
Flavanonas/administração & dosagem
Masculino
Quercetina/administração & dosagem
Ratos
Ratos Wistar
Serotonina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholinergic Agents); 0 (Flavanones); 333DO1RDJY (Serotonin); 9IKM0I5T1E (Quercetin); EC 3.1.1.7 (Acetylcholinesterase); HN5425SBF2 (naringenin); IT942ZTH98 (Curcumin); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


  4 / 3751 MEDLINE  
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[PMID]:29258053
[Au] Autor:Zhang T; Sharma A; Li Y; Zhou Y; Ding X
[Ad] Endereço:School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
[Ti] Título:Orthogonal Array composite design to study and optimize antioxidant combinations in the prevention of UVB-induced HSF damage.
[So] Source:J Photochem Photobiol B;178:568-576, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Excessive exposure to ultraviolet (UV) B radiation may lead to skin damage, photosensitivity, or even tumorigenesis via induction of oxidative stress. Naturally derived antioxidants could play significant roles in cancer therapy due to their multi-targeted actions and lack of substantial toxicity. Drug combinations target at diverse pathway of cells and make cells export meticulous biological outcomes through the multifaceted signaling network. The UVB protective effects of combinations of naturally derived antioxidants- curcumin, resveratrol, proanthocyanidins, baicalein, and beta-nicotinamide adenine dinucleotide (NADH) were investigated. An oxidative cell damage model was established to study the ultraviolet irradiation system. An orthogonal array composite design (OACD) was employed in the optimization of antioxidants combinations. Combination of resveratrol (0.1µM) and baicalein in medium concentration (0.2µM), with NADH in high concentration (0.8µM) was found to be the most efficacious combination among all the 30 runs performed using OACD. The findings suggested that UVB exposure-inflicted cell apoptosis can be significantly reduced by naturally-derived antioxidant combinations. These results provide an insight into the discovery of synergistic antioxidant combinations in skin cancer, using orthogonal array composite design (OACD). The results also have practical implications in the understanding of drug mechanisms in skin cancer, which can assist clinical practice by recommending better drug combinations.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Antioxidantes/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Curcumina/química
Curcumina/farmacologia
Fragmentação do DNA/efeitos dos fármacos
Fragmentação do DNA/efeitos da radiação
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/efeitos da radiação
Flavanonas/química
Flavanonas/farmacologia
Seres Humanos
Modelos Lineares
Estresse Oxidativo/efeitos da radiação
Proantocianidinas/química
Proantocianidinas/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Pele/citologia
Estilbenos/química
Estilbenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavanones); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 0 (Stilbenes); 49QAH60606 (baicalein); IT942ZTH98 (Curcumin); Q369O8926L (resveratrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  5 / 3751 MEDLINE  
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[PMID]:29208404
[Au] Autor:Rivoira M; Rodríguez V; Picotto G; Battaglino R; Tolosa de Talamoni N
[Ad] Endereço:Laboratorio "Dr. Cañas", Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
[Ti] Título:Naringin prevents bone loss in a rat model of type 1 Diabetes mellitus.
[So] Source:Arch Biochem Biophys;637:56-63, 2018 01 01.
[Is] ISSN:1096-0384
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this work was to know whether naringin (NA) could prevent the bone complications in a model of streptozotocin (STZ) induced diabetes. Rats were divided in: 1) controls, 2) STZ-rats, 3) STZ-rats treated with 40 mg NA/kg, and 4) STZ-rats treated with 80 mg NA/kg. BMD and BMC were performed by DEXA. Bone histomorphometry and histology as well as TRAP staining were done in tibia. Osteocalcin (OCN) was determined in bone and serum. Glutathione content and SOD and catalase activities were assayed in bone marrow from femur. The data showed that NA80 increased the BMD and BMC from the long bones of STZ-rats. Both NA40 and NA80 normalized the trabecular number and the trabecular separations. An increase in the number of adipocytes and TRAP(+) cells in tibia from STZ-rats was blocked by NA. NA40 treatment increased the number of OCN(+) cells, but only the NA80 treatment allowed to reach the control values. NA normalized the SOD and catalase activities in bone marrow of femur from STZ-rats. In conclusion, NA avoids alterations in the physical properties and microstructure of bone from STZ-rats probably by stimulation of osteoblastogenesis, inhibition of the osteoclastogenesis and adipogenesis via blocking the oxidative stress.
[Mh] Termos MeSH primário: Densidade Óssea/efeitos dos fármacos
Diabetes Mellitus Tipo 1/tratamento farmacológico
Flavanonas/farmacologia
Osteoporose/prevenção & controle
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adipócitos/efeitos dos fármacos
Adipócitos/patologia
Animais
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/metabolismo
Osso e Ossos/patologia
Catalase/metabolismo
Complicações do Diabetes/etiologia
Complicações do Diabetes/metabolismo
Complicações do Diabetes/prevenção & controle
Diabetes Mellitus Experimental/tratamento farmacológico
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Tipo 1/metabolismo
Relação Dose-Resposta a Droga
Flavanonas/administração & dosagem
Hipoglicemiantes/administração & dosagem
Hipoglicemiantes/farmacologia
Masculino
Osteocalcina/metabolismo
Osteogênese/efeitos dos fármacos
Osteoporose/etiologia
Osteoporose/metabolismo
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavanones); 0 (Hypoglycemic Agents); 104982-03-8 (Osteocalcin); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); N7TD9J649B (naringin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE


  6 / 3751 MEDLINE  
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[PMID]:28450224
[Au] Autor:Ahmed LA; Rizk SM; El-Maraghy SA
[Ad] Endereço:Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address: lamiaa.ahmed@pharma.cu.edu.eg.
[Ti] Título:Pinocembrin ex vivo preconditioning improves the therapeutic efficacy of endothelial progenitor cells in monocrotaline-induced pulmonary hypertension in rats.
[So] Source:Biochem Pharmacol;138:193-204, 2017 08 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pulmonary hypertension is still not curable and the available current therapies can only alleviate symptoms without hindering the progression of disease. The present study was directed to investigate the possible modulatory effect of pinocembrin on endothelial progenitor cells transplanted in monocrotaline-induced pulmonary hypertension in rats. Pulmonary hypertension was induced by a single subcutaneous injection of monocrotaline (60mg/kg). Endothelial progenitor cells were in vitro preconditioned with pinocembrin (25mg/L) for 30min before being i.v. injected into rats 2weeks after monocrotaline administration. Four weeks after monocrotaline administration, blood pressure, electrocardiography and right ventricular systolic pressure were recorded. Rats were sacrificed and serum was separated for determination of endothelin-1 and asymmetric dimethylarginine levels. Right ventricles and lungs were isolated for estimation of tumor necrosis factor-alpha and transforming growth factor-beta contents as well as caspase-3 activity. Moreover, protein expression of matrix metalloproteinase-9 and endothelial nitric oxide synthase in addition to myocardial connexin-43 was assessed. Finally, histological analysis of pulmonary arteries, cardiomyocyte cross-sectional area and right ventricular hypertrophy was performed and cryosections were done for estimation of cell homing. Preconditioning with pinocembrin provided a significant improvement in endothelial progenitor cells' effect towards reducing monocrotaline-induced elevation of inflammatory, fibrogenic and apoptotic markers. Furthermore, preconditioned cells induced a significant amelioration of endothelial markers and cell homing and prevented monocrotaline-induced changes in right ventricular function and histological analysis compared with native cells alone. In conclusion, pinocembrin significantly improves the therapeutic efficacy of endothelial progenitor cells in monocrotaline-induced pulmonary hypertension in rats.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Células da Medula Óssea/efeitos dos fármacos
Modelos Animais de Doenças
Células Progenitoras Endoteliais/efeitos dos fármacos
Células Progenitoras Endoteliais/transplante
Flavanonas/uso terapêutico
Hipertensão Pulmonar/cirurgia
[Mh] Termos MeSH secundário: Animais
Apoptose
Biomarcadores/sangue
Biomarcadores/metabolismo
Células da Medula Óssea/citologia
Células da Medula Óssea/imunologia
Transplante de Medula Óssea/efeitos adversos
Células Cultivadas
Citocinas/metabolismo
Células Progenitoras Endoteliais/citologia
Células Progenitoras Endoteliais/imunologia
Endotélio Vascular/imunologia
Endotélio Vascular/metabolismo
Endotélio Vascular/patologia
Rejeição de Enxerto/prevenção & controle
Ventrículos do Coração/imunologia
Ventrículos do Coração/metabolismo
Ventrículos do Coração/patologia
Ventrículos do Coração/fisiopatologia
Hipertensão Pulmonar/imunologia
Hipertensão Pulmonar/metabolismo
Hipertensão Pulmonar/fisiopatologia
Pulmão/irrigação sanguínea
Pulmão/imunologia
Pulmão/metabolismo
Pulmão/patologia
Masculino
Artéria Pulmonar/patologia
Distribuição Aleatória
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Biomarkers); 0 (Cytokines); 0 (Flavanones); 8T7C8CH791 (pinocembrin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  7 / 3751 MEDLINE  
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[PMID]:29223569
[Au] Autor:Singh AK; Raj V; Keshari AK; Rai A; Kumar P; Rawat A; Maity B; Kumar D; Prakash A; De A; Samanta A; Bhattacharya B; Saha S
[Ad] Endereço:Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, Uttar Pradesh, India.
[Ti] Título:Isolated mangiferin and naringenin exert antidiabetic effect via PPAR /GLUT4 dual agonistic action with strong metabolic regulation.
[So] Source:Chem Biol Interact;280:33-44, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In this study, we isolated two compounds from the leaves of Salacia oblonga (SA1, mangiferin and SA2, naringenin), and their structures were confirmed by infrared spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry. SA1 and SA2 were orally administered to streptozotocin-induced diabetic rats at 50 and 100 mg/kg daily for 15 days. Blood glucose level, serum lipid profile, oxidative stress parameters, histopathology, docking, molecular parameters, and NMR-based metabolic perturbation studies were performed to investigate the pharmacological activities of SA1 and SA2. Results suggested that both compounds reduced blood glucose level, restored body weight, and normalized lipid concentrations in the serum and oxidative stress biomarkers in the liver and pancreas. In addition, the docking study on several diabetes-associated targets revealed that both compounds had a strong binding affinity towards peroxisome proliferator-activated receptor gamma (PPAR ) and glucose transporter type 4 (GLUT4). Further real-time reverse transcription polymerase chain reaction and western blot analyses were performed to confirm the gene and protein expression levels of PPAR and GLUT4 in the pancreatic tissues. Data obtained from the molecular studies showed that both compounds exhibited antidiabetic effects through dual activation of PPAR /GLUT4 signaling pathways. Finally, the NMR-based metabolic studies showed that both compounds normalized the diabetogenic metabolites in the serum. Altogether, we concluded that SA1 and SA2 might be potential antidiabetic lead compounds for future drug development.
[Mh] Termos MeSH primário: Flavanonas/farmacologia
Transportador de Glucose Tipo 4/metabolismo
Hipoglicemiantes/farmacologia
PPAR gama/metabolismo
Xantonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Glicemia/análise
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/tratamento farmacológico
Flavanonas/isolamento & purificação
Flavanonas/uso terapêutico
Transportador de Glucose Tipo 4/agonistas
Transportador de Glucose Tipo 4/genética
Glicogênio/metabolismo
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/uso terapêutico
Insulina/sangue
Lipídeos/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Masculino
Simulação de Acoplamento Molecular
Estresse Oxidativo/efeitos dos fármacos
PPAR gama/agonistas
PPAR gama/genética
Pâncreas/efeitos dos fármacos
Pâncreas/metabolismo
Pâncreas/patologia
Estrutura Terciária de Proteína
Ratos
Salacia/química
Salacia/metabolismo
Transdução de Sinais/efeitos dos fármacos
Estreptozocina/toxicidade
Xantonas/isolamento & purificação
Xantonas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Flavanones); 0 (Glucose Transporter Type 4); 0 (Hypoglycemic Agents); 0 (Insulin); 0 (Lipids); 0 (PPAR gamma); 0 (Xanthones); 1M84LD0UMD (mangiferin); 5W494URQ81 (Streptozocin); 9005-79-2 (Glycogen); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171211
[St] Status:MEDLINE


  8 / 3751 MEDLINE  
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[PMID]:28458099
[Au] Autor:Seo UM; Nguyen DH; Zhao BT; Min BS; Woo MH
[Ad] Endereço:College of Pharmacy, Catholic University of Daegu, Gyeongsan 38430, Republic of Korea.
[Ti] Título:Flavanonol glucosides from the aerial parts of Agrimonia pilosa Ledeb. and their acetylcholinesterase inhibitory effects.
[So] Source:Carbohydr Res;445:75-79, 2017 Jun 05.
[Is] ISSN:1873-426X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two new flavanonol glucoside isomers, (2R,3S)-dihydrokaempferol 3-O-ß-D-glucoside (1) and (2S,3R)-dihydrokaempferol 3-O-ß-D-glucoside (2), were isolated from the aerial parts of Agrimonia pilosa Ledeb., along with eight known flavanonol glucosides (3-10). Their structures were determined on the basis of spectroscopic analysis. In addition, these compounds were evaluated to determine their acetylcholinesterase inhibitory activities. The results indicated that these compounds have moderate inhibitory effects, with IC values ranging from 76.59 ± 1.16 to 97.53 ± 1.64 µM, except compounds 1 and 4 were inactive.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Agrimonia/química
Flavanonas/química
Glucosídeos/química
Glucosídeos/farmacologia
Componentes Aéreos da Planta/química
[Mh] Termos MeSH secundário: Inibidores da Colinesterase/química
Inibidores da Colinesterase/farmacologia
Concentração Inibidora 50
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Flavanones); 0 (Glucosides); EC 3.1.1.7 (Acetylcholinesterase)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29100118
[Au] Autor:Sakalli S; Burkina V; Pilipenko N; Zlabek V; Zamaratskaia G
[Ad] Endereço:Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: sakalli@frov.jcu.cz.
[Ti] Título:In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone.
[So] Source:Chemosphere;192:105-112, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemicals are widely present in fruits, vegetables and other plants and have great health benefits owing to their antioxidant properties. They are naturally found in the aquatic environment as well as discharged from sewage treatment plants after their large consumption. Little is known about their impact on fish; particularly in light of their interactions with pharmaceuticals. Therefore, this study was designed to determine the effects of diosmin, naringenin, quercetin and idole-3-carbinol on CYP1A-dependent 7-ethoxyresorufin-O-deethylase (EROD) activity on rainbow trout hepatic microsomes in the presence of two pharmaceuticals: clotrimazole and dexamethasone. The interactions between the phytochemicals and pharmaceuticals used in this study were determined using a combination index. Hepatic microsomes were exposed to two concentrations (1-or 50 µM) of phytochemicals and pharmaceuticals separately and in combinations. Singly, clotrimazole inhibited EROD activity 40% and 90% of control, while dexamethasone did not. Naringenin and diosmin inhibited EROD activity alone up to 90% and 55% respectively, but activities were further inhibited in the presence of either pharmaceutical. The preliminary study of combinations of clotrimazole with phytochemicals primarily showed synergistic effects. While EROD activity was not inhibited in the presence of quercetin or indole-3-carbinol, significant and synergistic inhibition was detected when either of these was combined with clotrimazole or dexamethasone.
[Mh] Termos MeSH primário: Clotrimazol/química
Citocromo P-450 CYP1A1/química
Dexametasona/química
Diosmina/química
Proteínas de Peixes/química
Flavanonas/química
Indóis/química
Quercetina/química
[Mh] Termos MeSH secundário: Animais
Clotrimazol/farmacologia
Citocromo P-450 CYP1A1/metabolismo
Dexametasona/farmacologia
Diosmina/farmacologia
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Proteínas de Peixes/metabolismo
Flavanonas/farmacologia
Indóis/farmacologia
Cinética
Fígado/efeitos dos fármacos
Fígado/enzimologia
Microssomos Hepáticos/efeitos dos fármacos
Microssomos Hepáticos/enzimologia
Oncorhynchus mykiss/metabolismo
Quercetina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Fish Proteins); 0 (Flavanones); 0 (Indoles); 7QM776WJ5N (Diosmin); 7S5I7G3JQL (Dexamethasone); 9IKM0I5T1E (Quercetin); C11E72455F (indole-3-carbinol); EC 1.14.14.1 (Cytochrome P-450 CYP1A1); G07GZ97H65 (Clotrimazole); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  10 / 3751 MEDLINE  
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[PMID]:28747329
[Au] Autor:Pereira-Caro G; Polyviou T; Ludwig IA; Nastase AM; Moreno-Rojas JM; Garcia AL; Malkova D; Crozier A
[Ad] Endereço:Department of Food and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA)-Alameda del Obispo, Cordoba, Spain.
[Ti] Título:Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes.
[So] Source:Am J Clin Nutr;106(3):791-800, 2017 Sep.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Physical exercise has been reported to increase the bioavailability of citrus flavanones. We investigated the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained males before and after cessation of training for 7 d. Ten fit, endurance-trained males, with a mean ± SD maximal oxygen consumption of 58.2 ± 5.3 mL · kg · min , followed a low (poly)phenol diet for 2 d before drinking 500 mL of OJ containing 398 µmol of (poly)phenols, of which 330 µmol was flavanones. After the volunteers stopped training for 7 d the feeding study was repeated. Urine samples were collected 12 h pre- and 24 h post-OJ consumption. Bioavailability was assessed by the quantitative analysis of urinary flavanone metabolites and (poly)phenol catabolites with the use of high-pressure liquid chromatography-high resolution mass spectrometry. During training, 0-24-h urinary excretion of flavanone metabolites, mainly hesperetin-3'- -glucuronide, hesperetin-3'-sulfate, naringenin-4'- -glucuronide, naringenin-7- -glucuronide, was equivalent to 4.2% of OJ flavanone intake. This increased significantly to 5.2% when OJ was consumed after the volunteers stopped training for 7 d. Overall, this trend, although not significant, was also observed with OJ-derived colonic catabolites, which, after supplementation in the trained state, were excreted in amounts equivalent to 51% of intake compared with 59% after cessation of training. However, urinary excretion of 3 colonic catabolites of bacterial origin, most notably, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid, did increase significantly when OJ was consumed postcessation compared with precessation of training. Data were also obtained on interindividual variations in flavanone bioavailability. A 7-d cessation of endurance training enhanced, rather than reduced, the bioavailability of OJ flavanones. The biological significance of these differences and whether they extend to the bioavailability of other dietary (poly)phenols remain to be determined. Hesperetin-3'- -glucuronide and the colonic microbiota-derived catabolite 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic acid are key biomarkers of the consumption of hesperetin- -glycoside-containing OJ and other citrus products. This trial was registered at clinicaltrials.gov as NCT02627547.
[Mh] Termos MeSH primário: Citrus sinensis/química
Exercício/fisiologia
Flavanonas/farmacocinética
Resistência Física/fisiologia
Extratos Vegetais/farmacocinética
Polifenóis/farmacocinética
Descanso/fisiologia
[Mh] Termos MeSH secundário: Atletas
Disponibilidade Biológica
Cromatografia Líquida de Alta Pressão
Colo/metabolismo
Dieta
Flavanonas/urina
Frutas
Sucos de Frutas e Vegetais
Glucuronídeos/urina
Hesperidina/farmacocinética
Seres Humanos
Masculino
Espectrometria de Massas
Consumo de Oxigênio
Polifenóis/urina
Esportes/fisiologia
[Pt] Tipo de publicação:CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavanones); 0 (Glucuronides); 0 (Plant Extracts); 0 (Polyphenols); E750O06Y6O (Hesperidin); HN5425SBF2 (naringenin); Q9Q3D557F1 (hesperetin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170728
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.149898



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