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Pesquisa : D03.383.663.283.266.450.260.110 [Categoria DeCS]
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  1 / 1626 MEDLINE  
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[PMID]:29406244
[Au] Autor:Ashokkumar R; Jamuna S; Sakeena Sadullah MS; Niranjali Devaraj S
[Ad] Endereço:Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, India.
[Ti] Título:Vitexin protects isoproterenol induced post myocardial injury by modulating hipposignaling and ER stress responses.
[So] Source:Biochem Biophys Res Commun;496(2):731-737, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The molecular mechanisms involved in ER stress-induced post myocardial injury remain elusive. In this study, we have investigated the molecular mechanism of ER stress-mediated myocyte death in Isoproterenol (ISO) induced myocardial infarction and its inhibition by a potent anti oxidant and anti-apoptotic bioflavonoid, Vitexin. ISO mediated apoptosis was found to be associated with ER permeabilization and characterized by enhanced production of ROS, activation of caspase-3, modulation of Bcl2 family proteins and activation of bnip3. Moreover, post treatment with Vitexin inhibits the ISO induced translocation of CHOP to nucleus during MI. Further results have demonstrated that, activation of Mst1 through ER stress was diminished upon treatment with Vitexin. In addition to this, Vitexin treatment significantly downregulated the expression of p-Yap and p-Mst1 which were enhanced during post myocardial injury. Taken together, our data indicate that co-ordinated activation of ER stress and hipposignaling by ISO was ameliorated by the potent cardioprotective effects of Vitexin.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Apigenina/uso terapêutico
Cardiotônicos/uso terapêutico
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Infarto do Miocárdio/tratamento farmacológico
Miócitos Cardíacos/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Isoproterenol
Masculino
Infarto do Miocárdio/induzido quimicamente
Infarto do Miocárdio/patologia
Miócitos Cardíacos/patologia
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Ratos Wistar
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cardiotonic Agents); 0 (Proto-Oncogene Proteins c-bcl-2); 7V515PI7F6 (Apigenin); 9VP70K75OK (vitexin); EC 3.4.22.- (Caspase 3); L628TT009W (Isoproterenol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


  2 / 1626 MEDLINE  
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[PMID]:29236499
[Au] Autor:Vollmer M; Esders S; Farquharson FM; Neugart S; Duncan SH; Schreiner M; Louis P; Maul R; Rohn S
[Ad] Endereço:Institute of Food Chemistry, Hamburg School of Food Science, University of Hamburg , Grindelallee 117, 20146 Hamburg, Germany.
[Ti] Título:Mutual Interaction of Phenolic Compounds and Microbiota: Metabolism of Complex Phenolic Apigenin-C- and Kaempferol-O-Derivatives by Human Fecal Samples.
[So] Source:J Agric Food Chem;66(2):485-497, 2018 Jan 17.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Human colonic bacteria have an important impact on the biotransformation of flavonoid glycosides and their conversion can result in the formation of bioactive compounds. However, information about the microbial conversion of complex glycosylated flavonoids and the impact on the gut microbiota are still limited. In this study, in vitro fermentations with selected flavonoid O- and C-glycosides and three different fecal samples were performed. As a result, all flavonoid glycosides were metabolized via their aglycones yielding smaller substances. Main metabolites were 3-(4-hydroxyphenyl)propionic acid, 3-phenylpropionic acid, and phenylacetic acid. Differences in the metabolite formation due to different time courses between the donors were determined. Therefore, from all fermentations, the ones with a specific donor were always slower resulting in a lower number of metabolites compared to the others. For example, tiliroside was totally degraded from 0 h (105 ± 13.2 µM) within the first 24 h, while in the fermentations with fecal samples from other donors, tiliroside (107 ± 52.7 µM at 0 h) was not detected after 7 h anymore. In general, fermentation rates of C-glycosides were slower compared to the fermentation rates of O-glycosides. The O-glycoside tiliroside was degraded within 4 h while the gut microbiota converted the C-glycoside vitexin within 13 h. However, significant changes (p < 0.05) in the microbiota composition and short chain fatty acid levels as products of carbohydrate fermentation were not detected between incubations with different phenolic compounds. Therefore, microbiota diversity was not affected and a significant prebiotic effect of phenolic compounds cannot be assigned to flavonoid glycosides in food-relevant concentrations.
[Mh] Termos MeSH primário: Apigenina/metabolismo
Fezes/química
Microbioma Gastrointestinal
Quempferóis/metabolismo
Fenóis/metabolismo
[Mh] Termos MeSH secundário: Apigenina/química
Bactérias/genética
Bactérias/isolamento & purificação
Bactérias/metabolismo
Fezes/microbiologia
Seres Humanos
Intestinos/metabolismo
Intestinos/microbiologia
Quempferóis/química
Estrutura Molecular
Fenóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Kaempferols); 0 (Phenols); 731P2LE49E (kaempferol); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04842


  3 / 1626 MEDLINE  
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[PMID]:29191453
[Au] Autor:Gao AM; Zhang XY; Hu JN; Ke ZP
[Ad] Endereço:Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Department of Pharmacy, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
[Ti] Título:Apigenin sensitizes hepatocellular carcinoma cells to doxorubic through regulating miR-520b/ATG7 axis.
[So] Source:Chem Biol Interact;280:45-50, 2018 Jan 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Chemo-resistance is a serious obstacle for successful treatment of cancer. Apigenin, a dietary flavonoid, has been reported as an anticancer drug in various malignant cancers. This study aimed to investigate the potential chemo-sensitization effect of apigenin in doxorubicin-resistant hepatocellular carcinoma cell line BEL-7402/ADM. We observed that apigenin significantly enhanced doxorubicin sensitivity, induced miR-520b expression and inhibited ATG7-dependent autophagy in BEL-7402/ADM cells. In addition, we also showed that miR-520b mimics increased doxorubicin sensitivity and inhibited ATG7-dependent autophagy. Meanwhile, we indicated that ATG7 was a potential target of miR-520b. Furthermore, APG inhibited the growth of hepatocellar carcinoma xenografts in nude mice by up-regulating miR-520b and inhibiting ATG7. Our finding provides evidence that apigenin sensitizes BEL-7402/ADM cells to doxorubicin through miR-520b/ATG7 pathway, which furtherly supports apigenin as a potential chemo-sensitizer for hepatocellular carcinoma.
[Mh] Termos MeSH primário: Apigenina/farmacologia
Proteína 7 Relacionada à Autofagia/metabolismo
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
MicroRNAs/metabolismo
[Mh] Termos MeSH secundário: Animais
Antagomirs/metabolismo
Antagomirs/uso terapêutico
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Apigenina/uso terapêutico
Autofagia/efeitos dos fármacos
Proteína 7 Relacionada à Autofagia/química
Proteína 7 Relacionada à Autofagia/genética
Sequência de Bases
Carcinoma Hepatocelular/tratamento farmacológico
Carcinoma Hepatocelular/metabolismo
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Doxorrubicina/toxicidade
Seres Humanos
Neoplasias Hepáticas/tratamento farmacológico
Neoplasias Hepáticas/metabolismo
Neoplasias Hepáticas/patologia
Camundongos
Camundongos Nus
MicroRNAs/antagonistas & inibidores
MicroRNAs/genética
Alinhamento de Sequência
Transplante Heterólogo
Regulação para Cima/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antagomirs); 0 (Antineoplastic Agents); 0 (MicroRNAs); 7V515PI7F6 (Apigenin); 80168379AG (Doxorubicin); EC 6.2.1.45 (Autophagy-Related Protein 7); EC 6.3.2.19 (Atg7 protein, human)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  4 / 1626 MEDLINE  
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[PMID]:28449600
[Au] Autor:Adaszynska-Skwirzynska M; Dzieciol M
[Ad] Endereço:a Faculty of Biotechnology and Animal Husbandry , West Pomeranian University of Technology , Szczecin , Poland.
[Ti] Título:Comparison of phenolic acids and flavonoids contents in various cultivars and parts of common lavender (Lavandula angustifolia) derived from Poland.
[So] Source:Nat Prod Res;31(21):2575-2580, 2017 Nov.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of study was to compare the content of phenolic acids and flavonoids in two cultivars of Lavandula angustifolia: 'Blue River' and 'Ellagance Purple', including flowers and leafy stalks. Total phenolics and total flavonoids contents were determined by UV-Vis spectroscopy. The contents of total phenolics in leafy stalks (3.71-4.06 mg g d.m.) were higher than in flowers (1.13-1.14 mg g d.m.). Similarly, higher total contents of flavonoids were determined in leafy stalks (3.41-3.51 mg g d.m.), as compared with flowers (0.86-0.91 mg g d.m.). Phenolic acids and flavonoids were identified and quantified using HPLC and UPLC methods. Three phenolic acids were determined: rosmarinic, ferulic and caffeic acid. Lavender extracts contained also flavonoids from group of apigenin, luteolin and quercetin. Higher amounts of luteolin diglucuronide and luteolin glucuronide were found in leafy stalks in comparison to flowers. Obtained results indicate that leafy stalks of lavender can be also valuable source of antioxidant compounds.
[Mh] Termos MeSH primário: Flavonoides/análise
Hidroxibenzoatos/análise
Lavandula/química
[Mh] Termos MeSH secundário: Apigenina/análise
Ácidos Cafeicos/análise
Cromatografia Líquida de Alta Pressão/métodos
Flavonoides/química
Flores/química
Hidroxibenzoatos/química
Luteolina/análise
Óleos Voláteis/análise
Fenóis/análise
Polônia
Quercetina/análise
Espectrofotometria Ultravioleta/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Flavonoids); 0 (Hydroxybenzoates); 0 (Oils, Volatile); 0 (Phenols); 29656-58-4 (phenolic acid); 7V515PI7F6 (Apigenin); 9IKM0I5T1E (Quercetin); KUX1ZNC9J2 (Luteolin); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1320792


  5 / 1626 MEDLINE  
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[PMID]:28600852
[Au] Autor:Akogou FU; Kayodé AP; den Besten HM; Linnemann AR
[Ad] Endereço:Laboratory of Valorization and Quality Management of Food Bio-Ingredients (LaBio), DNSA/FSA, Université d'Abomey-Calavi, Cotonou, Benin.
[Ti] Título:Extraction methods and food uses of a natural red colorant from dye sorghum.
[So] Source:J Sci Food Agric;98(1):361-368, 2018 Jan.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The interest in stable natural colorants for food applications continues to grow. A red pigment extracted from the leaf sheaths of a sorghum variety (Sorghum bicolor) with a high content of apigeninidin is widely used as a biocolorant in processed foods in West Africa. This study compared the colour and anthocyanin composition from traditional extraction methods to determine options for improvement and use of the red biocolorant from dye sorghum in the food sector. RESULTS: Sorghum biocolorant was commonly applied in fermented and heated foods. Traditional extraction methods predominantly differed in two aspects, namely the use of an alkaline rock salt (locally known as kanwu) and the temperature of the extraction water. Cool extraction using the alkaline ingredient was more efficient than hot alkaline and hot aqueous extractions in extracting anthocyanins. The apigeninidin content was three times higher in the cool and hot alkaline extracts than in the aqueous extract. CONCLUSION: Cool and hot alkaline extractions at pH 8-9 were the most efficient methods for extracting apigeninidin from dye sorghum leaf sheaths. Broader use of the sorghum biocolorant in foods requires further research on its effects on nutrient bioavailability and antioxidant activity. © 2017 Society of Chemical Industry.
[Mh] Termos MeSH primário: Pigmentos Biológicos/isolamento & purificação
Extratos Vegetais/isolamento & purificação
Sorghum/química
[Mh] Termos MeSH secundário: Antocianinas/análise
Antocianinas/isolamento & purificação
Apigenina/análise
Apigenina/isolamento & purificação
Cor
Pigmentos Biológicos/análise
Extratos Vegetais/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Pigments, Biological); 0 (Plant Extracts); 7V515PI7F6 (Apigenin); CWI2JJB0W1 (apigeninidin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170611
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.8479


  6 / 1626 MEDLINE  
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[PMID]:29097249
[Au] Autor:Madunic J; Madunic IV; Gajski G; Popic J; Garaj-Vrhovac V
[Ad] Endereço:Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000, Zagreb, Croatia.
[Ti] Título:Apigenin: A dietary flavonoid with diverse anticancer properties.
[So] Source:Cancer Lett;413:11-22, 2018 Jan 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Apigenin is a natural flavonoid found in several dietary plant foods such as vegetables and fruits. A large number of studies conducted over the past years have shown that this particular natural compound has potential antioxidant, anti-inflammatory, and anticancer properties. Therefore, apigenin has generated a great deal of interest as a possible chemotherapeutic modality due to its low intrinsic toxicity and remarkable effects on normal versus cancerous cells, compared with other structurally related flavonoids. Here, we review its role in anticancer research, as well as several cancer signalling pathways, including MAPK, PI3K/Akt and NF-κB pathways, and their specific role in different cancer types. Based on the available literature, the beneficial effects of apigenin as a future anticancer modality are promising but they require further in vitro and in vivo studies to enable its translation from bench to bedside.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Apigenina/uso terapêutico
Dieta
Neoplasias/tratamento farmacológico
Compostos Fitoquímicos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Apoptose/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Transformação Celular Neoplásica/efeitos dos fármacos
Transformação Celular Neoplásica/metabolismo
Transformação Celular Neoplásica/patologia
Seres Humanos
Neoplasias/metabolismo
Neoplasias/patologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Phytochemicals); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171104
[St] Status:MEDLINE


  7 / 1626 MEDLINE  
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[PMID]:29022496
[Au] Autor:Medhat AM; Azab KS; Said MM; El Fatih NM; El Bakary NM
[Ad] Endereço:1 Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
[Ti] Título:Antitumor and radiosensitizing synergistic effects of apigenin and cryptotanshinone against solid Ehrlich carcinoma in female mice.
[So] Source:Tumour Biol;39(10):1010428317728480, 2017 Oct.
[Is] ISSN:1423-0380
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Considerable attention has been paid to the introduction of novel naturally occurring plant-derived radiosensitizer compounds in order to augment the radiation efficacy and improve the treatment outcome of different tumors. This study was therefore undertaken to evaluate the antitumor, antiangiogeneic, and synergistic radiosensitizing effects of apigenin, a dietary flavonoid, and/or cryptotanshinone, a terpenoid isolated from the roots of Salvia miltiorrhiza, against the growth of solid Ehrlich carcinoma in female mice. Apigenin (50 mg/kg body weight) and/or cryptotanshinone (40 mg/kg body weight) was intraperitoneally (i.p.) injected into non-irradiated or γ-irradiated (6.5 Gy whole-body γ-irradiation) solid Ehrlich carcinoma-bearing mice for 30 consecutive days. Investigations included molecular targets involved in proliferation, inflammation, angiogenesis, and tumor invasiveness. Treatment with apigenin and/or cryptotanshinone significantly suppressed the growth of solid Ehrlich carcinoma tumors and demonstrated a synergistic radiosensitizing efficacy together with γ-irradiation. These effects were achieved through downregulating the expression of angiogenic and lymphangiogenic regulators, including signal transducer and activator of transcription 3, vascular endothelial growth factor C, and tumor necrosis factor alpha, suppressing matrix metalloproteinase-2 and -9 activities, which play a key role in tumor invasion and metastasis, and enhancing apoptosis via inducing cleaved caspase-3 and granzyme B levels. Histological findings of solid Ehrlich carcinoma tumors verified the recorded data. In conclusion, a synergistic radiosensitizing efficacy for apigenin and cryptotanshinone was demonstrated against Ehrlich carcinoma in the current in vivo murine model, representing therefore a potential therapeutic strategy for increasing the radiation response of solid tumors.
[Mh] Termos MeSH primário: Apigenina/administração & dosagem
Carcinoma de Ehrlich/tratamento farmacológico
Carcinoma de Ehrlich/radioterapia
Radiossensibilizantes/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Carcinoma de Ehrlich/patologia
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/efeitos da radiação
Modelos Animais de Doenças
Feminino
Raios gama
Seres Humanos
Camundongos
Fenantrenos/administração & dosagem
Irradiação Corporal Total
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenanthrenes); 0 (Radiation-Sensitizing Agents); 5E9SXT166N (cryptotanshinone); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171013
[St] Status:MEDLINE
[do] DOI:10.1177/1010428317728480


  8 / 1626 MEDLINE  
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[PMID]:28891090
[Au] Autor:Ganesan K; Xu B
[Ad] Endereço:Food Science and Technology Program, Beijing Normal University-Hong Kong Baptist University United International College, Zhuhai, Guangdong, China.
[Ti] Título:Molecular targets of vitexin and isovitexin in cancer therapy: a critical review.
[So] Source:Ann N Y Acad Sci;1401(1):102-113, 2017 Aug.
[Is] ISSN:1749-6632
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cancer is a primary public health problem and the second leading cause of death worldwide. It causes life-threatening malignancies and results in high financial costs for both patients and the healthcare system. Hence, it is important to develop effective long-term strategies pertaining to prevention and control of cancers. Plant-derived secondary metabolites have been shown to have positive roles against various cancers. A number of plant extracts have been evaluated for possible use in the treatment of cancer; some have provided direction for new strategies for the research and development of antitumor agents. Here, we provide comprehensive data on various cancers, potential molecular mechanisms, and therapeutic implications of just two plant-derived compounds, vitexin and isovitexin. Information on the chemotherapeutic potential of vitexin and isovitexin was collected from a library database and through electronic searches (ScienceDirect, Pubmed, and Google Scholar). Both in vitro and in vivo studies suggest that vitexin and isovitexin are chemopreventive compounds with activity against various cancers through proapoptotic processes and/or autophagy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Apigenina/uso terapêutico
Neoplasias/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Apigenina/isolamento & purificação
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Seres Humanos
Neoplasias/metabolismo
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 7V515PI7F6 (Apigenin); 9VP70K75OK (vitexin); KTQ9R9MS0Q (isovitexin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170912
[St] Status:MEDLINE
[do] DOI:10.1111/nyas.13446


  9 / 1626 MEDLINE  
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[PMID]:28867192
[Au] Autor:Zhou RJ; Ye H; Wang F; Wang JL; Xie ML
[Ad] Endereço:Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China.
[Ti] Título:Apigenin inhibits d-galactosamine/LPS-induced liver injury through upregulation of hepatic Nrf-2 and PPARγ expressions in mice.
[So] Source:Biochem Biophys Res Commun;493(1):625-630, 2017 Nov 04.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Apigenin is a natural flavonoid compound widely distributed in a variety of vegetables, medicinal plants and health foods. This study aimed to examine the protective effect of apigenin against d-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced mouse liver injury and to investigate the potential biochemical mechanisms. The results showed that after oral administration of apigenin 100-200 mg/kg for 7 days, the levels of serum alanine aminotransferase and aspartate aminotransferase were decreased, and the severity of liver injury was alleviated. Importantly, apigenin pretreatment increased the levels of hepatic nuclear factor erythroid 2-related factor 2 (Nrf-2) and peroxisome proliferator-activated receptor γ (PPARγ) protein expressions as well as superoxide dismutase, catalase, glutathione S-transferase and glutathione reductase activities, decreased the levels of hepatic nuclear factor-κB (NF-κB) protein expression and tumor necrosis factor-α. These findings demonstrated that apigenin could prevent the D-GalN/LPS-induced liver injury in mice, and its mechanisms might be associated with the increments of Nrf-2-mediated antioxidative enzymes and modulation of PPARγ/NF-κB-mediated inflammation.
[Mh] Termos MeSH primário: Apigenina/administração & dosagem
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Fígado/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
PPAR gama/metabolismo
[Mh] Termos MeSH secundário: Administração Oral
Animais
Doença Hepática Induzida por Substâncias e Drogas/patologia
Relação Dose-Resposta a Droga
Galactosamina
Lipopolissacarídeos
Fígado/patologia
Masculino
Camundongos
Camundongos Endogâmicos ICR
Espécies Reativas de Oxigênio/metabolismo
Resultado do Tratamento
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, mouse); 0 (PPAR gamma); 0 (Reactive Oxygen Species); 7535-00-4 (Galactosamine); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171023
[Lr] Data última revisão:
171023
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:28829588
[Au] Autor:Shan S; Shi J; Yang P; Jia B; Wu H; Zhang X; Li Z
[Ad] Endereço:Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Institute of Biotechnology, Shanxi University , Taiyuan 030006, China.
[Ti] Título:Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.
[So] Source:J Agric Food Chem;65(37):8136-8144, 2017 Sep 20.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Apigenin (AP), as an anticancer agent, has been widely explored. However, the molecular targets of apigenin on tumor metabolism are unclear. Herein, we found that AP could block cellular glycolysis through restraining the tumor-specific pyruvate kinase M2 (PKM2) activity and expression and further significantly induce anti-colon cancer effects. The IC values of AP against HCT116, HT29, and DLD1 cells were 27.9 ± 2.45, 48.2 ± 3.01 and 89.5 ± 4.89 µM, respectively. Fluorescence spectra and solid-phase AP extraction assays proved that AP could directly bind to PKM2 and markedly inhibit PKM2 activity in vitro and in HCT116 cells. Interestingly, in the presence of d-fructose-1,6-diphosphate (FBP), the inhibitory effect of AP on PKM2 was not reversed, which suggests that AP is a new allosteric inhibitor of PKM2. RT-PCR and Western blot assays showed that AP could ensure a low PKM2/PKM1 ratio in HCT116 cells via blocking the ß-catenin/c-Myc/PTBP1 signal pathway. Hence, PKM2 represents a novel potential target of AP against colon cancer.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apigenina/farmacologia
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/fisiopatologia
Piruvato Quinase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Neoplasias do Colo/tratamento farmacológico
Neoplasias do Colo/enzimologia
Neoplasias do Colo/genética
Glicólise/efeitos dos fármacos
Seres Humanos
Piruvato Quinase/genética
Piruvato Quinase/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 7V515PI7F6 (Apigenin); EC 2.7.1.40 (Pyruvate Kinase)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02757



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