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[PMID]: | 27815700 |
[Au] Autor: | Schiano di Visconte M; Nicolì F; Del Giudice R; Cipolat Mis T |
[Ad] Endereço: | Department of General Surgery and Colorectal Surgery, S. Maria dei Battuti Hospital, Via Brigata Bisagno, 4, 31015, Conegliano, Veneto (TV), Italy. mschianodivisconte@gmail.com. |
[Ti] Título: | Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. |
[So] Source: | Int J Colorectal Dis;32(3):425-431, 2017 Mar. | [Is] ISSN: | 1432-1262 |
[Cp] País de publicação: | Germany |
[La] Idioma: | eng |
[Ab] Resumo: | PURPOSE: We evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and Centella asiatica (Venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (SA). METHODS: SA was conducted in 182 patients with third-degree hemorrhoids. Preoperatively, patients were randomized evenly into two groups. Group A patients were administered Venoplant for 30 days post-SA, and group B received a placebo for 30 days post-SA. Patients received paracetamol for postoperative pain. Visit (v)1, v2, and v3 took place 7, 15, and 30 days postoperatively, respectively; bleeding (clinical examination), visual analog scale (VAS), thrombosis (clinical examination), and pain (paracetamol dosage, VAS) were evaluated. RESULTS: At v1, v2, and v3, the numbers of patients with bleeding in groups A and B were 21 and 46, 3 and 25, and 1 and 5, respectively (p < 0.05). At v1, v2, and v3, the numbers of patients in groups A and B with thrombosed internal hemorrhoids were 3 and 13, 2 and 11, and 1 and 8, respectively (p < 0.05). The number of patients who took at least one paracetamol tablet was similar in both groups at v1 but was significantly greater in group B than group A at v2 and v3 (p < 0.05); pain VAS scores were equivalent at v1 and significantly greater in group B than group A at v2 and v3 (p < 0.05). CONCLUSIONS: Venoplant effectively reduced bleeding after SA, decreased the incidence of thrombosed internal hemorrhoids, and decreased postoperative pain. |
[Mh] Termos MeSH primário: |
Perda Sanguínea Cirúrgica Cumarínicos/uso terapêutico Procedimentos Cirúrgicos do Sistema Digestório Diosmina/uso terapêutico Dor Pós-Operatória/tratamento farmacológico Grampeamento Cirúrgico Trombose/tratamento farmacológico Triterpenos/uso terapêutico
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[Mh] Termos MeSH secundário: |
Acetaminofen/uso terapêutico Adulto Idoso Demografia Feminino Glicosídeos/uso terapêutico Hemorroidas/tratamento farmacológico Seres Humanos Masculino Meia-Idade Medição da Dor Dor Pós-Operatória/etiologia Placebos Estudos Prospectivos
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL |
[Nm] Nome de substância:
| 0 (Coumarins); 0 (Glycosides); 0 (Placebos); 0 (Triterpenes); 362O9ITL9D (Acetaminophen); 7QM776WJ5N (Diosmin); A4VZ22K1WT (coumarin) |
[Em] Mês de entrada: | 1706 |
[Cu] Atualização por classe: | 170926 |
[Lr] Data última revisão:
| 170926 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 161106 |
[St] Status: | MEDLINE |
[do] DOI: | 10.1007/s00384-016-2698-z |
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