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[PMID]: 29100118 [Au] Autor: Sakalli S; Burkina V; Pilipenko N; Zlabek V; Zamaratskaia G [Ad] Endereço: Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in Ceske Budejovice, Zatisi 728/II, 389 25 Vodnany, Czech Republic. Electronic address: sakalli@frov.jcu.cz. [Ti] Título: In vitro effects of diosmin, naringenin, quercetin and indole-3-carbinol on fish hepatic CYP1A1 in the presence of clotrimazole and dexamethasone. [So] Source: Chemosphere;192:105-112, 2018 Feb. [Is] ISSN: 1879-1298 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Phytochemicals are widely present in fruits, vegetables and other plants and have great health benefits owing to their antioxidant properties. They are naturally found in the aquatic environment as well as discharged from sewage treatment plants after their large consumption. Little is known about their impact on fish; particularly in light of their interactions with pharmaceuticals. Therefore, this study was designed to determine the effects of diosmin, naringenin, quercetin and idole-3-carbinol on CYP1A-dependent 7-ethoxyresorufin-O-deethylase (EROD) activity on rainbow trout hepatic microsomes in the presence of two pharmaceuticals: clotrimazole and dexamethasone. The interactions between the phytochemicals and pharmaceuticals used in this study were determined using a combination index. Hepatic microsomes were exposed to two concentrations (1-or 50 µM) of phytochemicals and pharmaceuticals separately and in combinations. Singly, clotrimazole inhibited EROD activity 40% and 90% of control, while dexamethasone did not. Naringenin and diosmin inhibited EROD activity alone up to 90% and 55% respectively, but activities were further inhibited in the presence of either pharmaceutical. The preliminary study of combinations of clotrimazole with phytochemicals primarily showed synergistic effects. While EROD activity was not inhibited in the presence of quercetin or indole-3-carbinol, significant and synergistic inhibition was detected when either of these was combined with clotrimazole or dexamethasone. [Mh] Termos MeSH primário: Clotrimazol/química Citocromo P-450 CYP1A1/química Dexametasona/química Diosmina/química Proteínas de Peixes/química Flavanonas/química Indóis/química Quercetina/química [Mh] Termos MeSH secundário: Animais Clotrimazol/farmacologia Citocromo P-450 CYP1A1/metabolismo Dexametasona/farmacologia Diosmina/farmacologia Inibidores Enzimáticos/química Inibidores Enzimáticos/farmacologia Proteínas de Peixes/metabolismo Flavanonas/farmacologia Indóis/farmacologia Cinética Fígado/efeitos dos fármacos Fígado/enzimologia Microssomos Hepáticos/efeitos dos fármacos Microssomos Hepáticos/enzimologia Oncorhynchus mykiss/metabolismo Quercetina/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Enzyme Inhibitors); 0 (Fish Proteins); 0 (Flavanones); 0 (Indoles); 7QM776WJ5N (Diosmin); 7S5I7G3JQL (Dexamethasone); 9IKM0I5T1E (Quercetin); C11E72455F (indole-3-carbinol); EC 1.14.14.1 (Cytochrome P-450 CYP1A1); G07GZ97H65 (Clotrimazole); HN5425SBF2 (naringenin) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180123 [Lr] Data última revisão: 180123 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171104 [St] Status: MEDLINE

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[PMID]: 28625489 [Au] Autor: Bertozzi MM; Rossaneis AC; Fattori V; Longhi-Balbinot DT; Freitas A; Cunha FQ; Alves-Filho JC; Cunha TM; Casagrande R; Verri WA [Ad] Endereço: Department of General Pathology, Biological Sciences Center, Londrina State University, Rod. Celso Garcia Cid PR 445, Km 380 Cx. Postal 10.011, 86057-970 Londrina, Parana, Brazil. [Ti] Título: Diosmin reduces chronic constriction injury-induced neuropathic pain in mice. [So] Source: Chem Biol Interact;273:180-189, 2017 Aug 01. [Is] ISSN: 1872-7786 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: Injury or dysfunction of somatosensory system induces a complex syndrome called neuropathic pain, which still needs adequate pharmacological control. The current pharmacological treatments were in part developed from natural compounds. Flavonoids are natural polyphenolic molecules presenting varied biological activities and low toxicity. The flavonoid diosmin is a safe compound with good tolerability and low toxicity. This study evaluated the antinociceptive effect of diosmin in the sciatic nerve chronic constriction injury (CCI)-induced neuropathic pain model. Male Swiss mice were submitted to CCI and 7 days after, diosmin at 1 or 10 mg/kg was administrated intraperitoneally. Mechanical (electronic analgesimeter) and thermal (hot plate) hyperalgesia were evaluated 1-24 h after treatment. The role of the NO/cGMP/PKG/KATP channel signaling pathway in the analgesic effect of diosmin was evaluated using the pretreatment with L-NAME (an inhibitor of NOS), ODQ (an inhibitor of soluble guanylate cyclase), KT5823 (an inhibitor of PKG), or glibenclamide (an ATP-sensitive K+ channels blocker). Single treatment with diosmin inhibited in a dose-dependent manner CCI-induced mechanical and thermal hyperalgesia by activating the NO/cGMP/PKG/KATP channel signaling pathway and inhibiting spinal cord cytokine (Il-1ß and Il-33/St2) and glial cells activation (microglia - Iba-1, oligodendrocytes - Olig2) mRNA expression markers. Daily treatment during 7 days with diosmin inhibited CCI-induced mechanical and thermal hyperalgesia by inhibiting spinal cord cytokine (Il-1ß, Tnfα, and Il-33/St2) and glial cells activation (astrocytes - Gfap, Iba-1, and Olig2) markers mRNA expression. In conclusion, diosmin inhibits neuropathic spinal cord nociceptive mechanisms suggesting this flavonoid as a potential therapeutic molecule to reduce nerve lesion-induced neuropathic pain. [Mh] Termos MeSH primário: Dor Crônica/tratamento farmacológico Diosmina/uso terapêutico Hiperalgesia/tratamento farmacológico [Mh] Termos MeSH secundário: Animais Dor Crônica/metabolismo Dor Crônica/patologia Constrição Diosmina/administração & dosagem Hiperalgesia/metabolismo Hiperalgesia/patologia Injeções Intraperitoneais Masculino Camundongos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171002 [Lr] Data última revisão: 171002 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170620 [St] Status: MEDLINE

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[PMID]: 28390258 [Au] Autor: Kamel R; Abbas H; Fayez A [Ad] Endereço: Pharmaceutical Technology Department, National Research Center, Cairo, Egypt. Electronic address: drrababk@hotmail.com. [Ti] Título: Diosmin/essential oil combination for dermal photo-protection using a lipoid colloidal carrier. [So] Source: J Photochem Photobiol B;170:49-57, 2017 May. [Is] ISSN: 1873-2682 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Solar irradiation induces skin inflammatory processes causing deleterious effects like premature ageing. In this study, the designed lipoid colloidal carrier (LCC) was loaded with Diosmin in combination with different essential oils, to be used as a topical photo-protective preparation. To investigate the ability of the essential oils to potentiate Diosmin effects, the Diosmin/essential oil-loaded LCCs (LCC2, LCC3 and LCC4) were compared to the Diosmin-loaded LCC (LCC1). The incorporated essential oils were those of Rosmarinus officinalis, Zingiber officinale or Vitis vinifera in LCC2, LCC3 and LCC4, respectively. All the LCCs had particle size (PS) values ranging from 121.1 to 144.3nm with uniform distribution and, zeta potential (Z) values around 30mV. Also, they all had high drug encapsulation efficiencies. LCC1 had the lowest anti-oxidant and in-vitro sun-blocking effect (p<0.05). In-vivo photo-protective studies showed that all the formulated LCCs had a skin protective effect when compared to the positive control (p<0.05); however LCC1 had the lowest anti-erythemal and anti-wrinkling effect. Histological studies proved the efficacy of the designed LCCs as skin anti-photoageing, with LCC1 showing the lowest anti-inflammatory and anti-wrinkling effect, while LCC2 had the highest anti-wrinkling effect. These results indicated that the suggested Diosmin/essential oil combinations improved the anti-oxidant, sun-blocking and anti-photoageing effects of Diosmin. After one year of storage, the LCCs showed satisfactory physical stability. This study presents the designed LCCs as safe and effective nano-structured dermal care products containing 'all-natural' components. [Mh] Termos MeSH primário: Diosmina/química Portadores de Fármacos/química Óleos Voláteis/química Protetores Solares/química [Mh] Termos MeSH secundário: Animais Antioxidantes/química Gengibre/química Gengibre/metabolismo Masculino Camundongos Microscopia Eletrônica de Transmissão Nanoestruturas/química Tamanho da Partícula Rosmarinus/química Rosmarinus/metabolismo Pele/efeitos dos fármacos Pele/patologia Pele/efeitos da radiação Protetores Solares/farmacologia Raios Ultravioleta Vitis/química Vitis/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Drug Carriers); 0 (Oils, Volatile); 0 (Sunscreening Agents); 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170920 [Lr] Data última revisão: 170920 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170409 [St] Status: MEDLINE

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[PMID]: 28177765 [Au] Autor: Hasan HF; Abdel-Rafei MK; Galal SM [Ad] Endereço: a Radiation Biology Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, PO Box 29, Nasr City, Cairo, Egypt. [Ti] Título: Diosmin attenuates radiation-induced hepatic fibrosis by boosting PPAR-γ expression and hampering miR-17-5p-activated canonical Wnt-ß-catenin signaling. [So] Source: Biochem Cell Biol;95(3):400-414, 2017 Jun. [Is] ISSN: 1208-6002 [Cp] País de publicação: Canada [La] Idioma: eng [Ab] Resumo: BACKGROUND: Liver fibrosis is one of the major complications from upper right quadrant radiotherapy. MicroRNA-17-5p (miR-17-5p) is hypothesized to act as a regulator of hepatic stellate cell (HSCs) activation by activation of the canonical Wnt-ß-catenin pathway. Diosmin (Dios), a citrus bioflavonoid, is known to possess potent antioxidant, anti-inflammatory, and anti-apoptotic properties. PURPOSE: To explore the molecular mechanisms that underlie radiation-induced liver fibrosis, and to evaluate the possible influence of Dios on the miR-17-5p-Wnt-ß-catenin signaling axis during fibrogenesis provoked by irradiation (IRR) in rats. Also, the effect of Dios on hepatic peroxisome proliferator activated receptor-γ (PPAR-γ) expression as a regulator for HSC activation was considered. METHODS: We administered 100 mg·(kg body mass) ·day (per oral) of Dios were administered to IRR-exposed rats (overall dose of 12 Gy on 6 fractions of 2 Gy each) for 6 successive weeks. RESULTS: Data analysis revealed that Dios treatment mitigated oxidative stress, enhanced antioxidant defenses, alleviated hepatic inflammatory responses, abrogated pro-fibrogenic cytokines, and stimulated PPAR-γ expression. Dios treatment repressed the miR-17-5p activated Wnt-ß-catenin signaling induced by IRR. Moreover, Dios treatment restored the normal hepatic architecture and reversed pathological alterations induced by IRR. CONCLUSION: We hypothesize that the stimulation of PPAR-γ expression and interference with miR-17-5p activated Wnt-ß-catenin signaling mediates the antifibrotic properties of Dios. [Mh] Termos MeSH primário: Diosmina/farmacologia Raios gama/efeitos adversos Cirrose Hepática/prevenção & controle MicroRNAs/genética PPAR gama/metabolismo Proteína Wnt1/metabolismo beta Catenina/metabolismo [Mh] Termos MeSH secundário: Animais Apoptose/efeitos dos fármacos Apoptose/efeitos da radiação Western Blotting Proliferação Celular/efeitos dos fármacos Proliferação Celular/efeitos da radiação Células Cultivadas Células Estreladas do Fígado/efeitos dos fármacos Células Estreladas do Fígado/efeitos da radiação Cirrose Hepática/etiologia Cirrose Hepática/metabolismo Masculino PPAR gama/genética RNA Mensageiro/genética Ratos Reação em Cadeia da Polimerase em Tempo Real Reação em Cadeia da Polimerase Via Transcriptase Reversa Proteína Wnt1/genética beta Catenina/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (MIRN17 microRNA, rat); 0 (MicroRNAs); 0 (PPAR gamma); 0 (PPAR gamma, rat); 0 (RNA, Messenger); 0 (Wnt1 Protein); 0 (Wnt1 protein, rat); 0 (beta Catenin); 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170815 [Lr] Data última revisão: 170815 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170209 [St] Status: MEDLINE [do] DOI: 10.1139/bcb-2016-0142

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[PMID]: 27890807 [Au] Autor: Lewinska A; Adamczyk-Grochala J; Kwasniewicz E; Deregowska A; Wnuk M [Ad] Endereço: Department of Genetics, University of Rzeszow, Werynia 502, 36-100 Kolbuszowa, Poland. Electronic address: alewinska@o2.pl. [Ti] Título: Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. [So] Source: Toxicol Lett;265:117-130, 2017 Jan 04. [Is] ISSN: 1879-3169 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Relatively low bioavailability of plant-derived nutraceuticals with anticancer properties may limit their usefulness for prevention and therapy of cancer. In the present study, we have screened for nutraceuticals (n=30) that would act at low micromolar range against phenotypically distinct breast cancer cell lines, namely MCF-7 (ER , PR , HER2 ), MDA-MB-231 (ER , PR , HER2 ) and SK-BR-3 (ER , PR , HER2 ), and diosmin, a citrus fruit flavonoid belonging to a flavone subclass, was selected. MCF-7 cell line was found to be the most sensitive to diosmin treatment. Diosmin caused G2/M cell cycle arrest, elevation in p53, p21 and p27 levels and stress-induced premature senescence when used at lower concentrations (5 and 10µM). Diosmin (20µM) also promoted apoptosis that was not observed in normal human mammary epithelial cells (HMEC). Diosmin stimulated oxidative and nitrosative stress, DNA damage and changes in global DNA methylation patterns. The status of p53 (wild type versus mutant) and the levels of phosphorylated ERK1/2 in a steady state, and diosmin-induced autophagy may reflect diverse response to diosmin treatment in MCF-7, MDA-MB-231 and SK-BR-3 cells, which in turn results in different cell fates. Taken together, diosmin that acts at low micromolar range against breast cancer cells may be considered as a promising candidate for anticancer therapy. [Mh] Termos MeSH primário: Anticarcinógenos/farmacologia Apoptose/efeitos dos fármacos Autofagia/efeitos dos fármacos Senescência Celular/efeitos dos fármacos Diosmina/farmacologia Sistema de Sinalização das MAP Quinases/efeitos dos fármacos Proteína Supressora de Tumor p53/metabolismo [Mh] Termos MeSH secundário: Western Blotting Neoplasias da Mama/metabolismo Neoplasias da Mama/patologia Técnicas de Cultura de Células Linhagem Celular Tumoral Sobrevivência Celular/efeitos dos fármacos Células Epiteliais/efeitos dos fármacos Feminino Seres Humanos Células MCF-7 Estresse Oxidativo/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anticarcinogenic Agents); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161129 [St] Status: MEDLINE

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[PMID]: 27815700 [Au] Autor: Schiano di Visconte M; Nicolì F; Del Giudice R; Cipolat Mis T [Ad] Endereço: Department of General Surgery and Colorectal Surgery, S. Maria dei Battuti Hospital, Via Brigata Bisagno, 4, 31015, Conegliano, Veneto (TV), Italy. mschianodivisconte@gmail.com. [Ti] Título: Effect of a mixture of diosmin, coumarin glycosides, and triterpenes on bleeding, thrombosis, and pain after stapled anopexy: a prospective, randomized, placebo-controlled clinical trial. [So] Source: Int J Colorectal Dis;32(3):425-431, 2017 Mar. [Is] ISSN: 1432-1262 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: PURPOSE: We evaluated the efficacy of oral administration of a mixture of diosmin, coumarin glycosides, and Centella asiatica (Venoplant®) in preventing bleeding, pain, and thrombosis of internal and external hemorrhoids after stapled anopexy (SA). METHODS: SA was conducted in 182 patients with third-degree hemorrhoids. Preoperatively, patients were randomized evenly into two groups. Group A patients were administered Venoplant for 30 days post-SA, and group B received a placebo for 30 days post-SA. Patients received paracetamol for postoperative pain. Visit (v)1, v2, and v3 took place 7, 15, and 30 days postoperatively, respectively; bleeding (clinical examination), visual analog scale (VAS), thrombosis (clinical examination), and pain (paracetamol dosage, VAS) were evaluated. RESULTS: At v1, v2, and v3, the numbers of patients with bleeding in groups A and B were 21 and 46, 3 and 25, and 1 and 5, respectively (p < 0.05). At v1, v2, and v3, the numbers of patients in groups A and B with thrombosed internal hemorrhoids were 3 and 13, 2 and 11, and 1 and 8, respectively (p < 0.05). The number of patients who took at least one paracetamol tablet was similar in both groups at v1 but was significantly greater in group B than group A at v2 and v3 (p < 0.05); pain VAS scores were equivalent at v1 and significantly greater in group B than group A at v2 and v3 (p < 0.05). CONCLUSIONS: Venoplant effectively reduced bleeding after SA, decreased the incidence of thrombosed internal hemorrhoids, and decreased postoperative pain. [Mh] Termos MeSH primário: Perda Sanguínea Cirúrgica Cumarínicos/uso terapêutico Procedimentos Cirúrgicos do Sistema Digestório Diosmina/uso terapêutico Dor Pós-Operatória/tratamento farmacológico Grampeamento Cirúrgico Trombose/tratamento farmacológico Triterpenos/uso terapêutico [Mh] Termos MeSH secundário: Acetaminofen/uso terapêutico Adulto Idoso Demografia Feminino Glicosídeos/uso terapêutico Hemorroidas/tratamento farmacológico Seres Humanos Masculino Meia-Idade Medição da Dor Dor Pós-Operatória/etiologia Placebos Estudos Prospectivos [Pt] Tipo de publicação: JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Coumarins); 0 (Glycosides); 0 (Placebos); 0 (Triterpenes); 362O9ITL9D (Acetaminophen); 7QM776WJ5N (Diosmin); A4VZ22K1WT (coumarin) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170926 [Lr] Data última revisão: 170926 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161106 [St] Status: MEDLINE [do] DOI: 10.1007/s00384-016-2698-z

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[PMID]: 27690733 [Au] Autor: Bedada SK; Boga PK [Ad] Endereço: a Drug Metabolism and Pharmacokinetics Division, University College of Pharmaceutical Sciences, Kakatiya University , Warangal , Telangana State , India. [Ti] Título: Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. [So] Source: Xenobiotica;47(10):879-884, 2017 Oct. [Is] ISSN: 1366-5928 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: 1. Carbamazepine (CBZ) is an antiepileptic drug with narrow therapeutic window and administration in humans receiving long-term therapy with diosmin (DSN) may occur, which leads to CYP3A4-mediated drug interactions. The purpose of the present study was to assess the influence of DSN on the metabolism and pharmacokinetics of CBZ in healthy volunteers. 2. An open-label, sequential, two-period study was conducted in 12 healthy male volunteers. A single dose of DSN 500 mg was administered once daily for 10 days during treatment phase. A single dose of CBZ 200 mg was administered during control and after treatment phases under fasting conditions. The blood samples were collected after CBZ dosing at predetermined time intervals and analyzed by LC-MS/MS. 3. Treatment with DSN significantly enhanced the maximum plasma concentration (C ) area under the curve (AUC), half-life (t ) and significantly decreased the apparent oral clearance (CL/F) and elimination rate constant (K ) of CBZ. On the other hand, treatment with DSN significantly decreased the C and AUC of carbamazepine 10, 11-epoxide (CBZE). Furthermore, treatment with DSN significantly decreased the metabolite to parent ratios of C and AUC, indicating the reduced metabolism of CBZ to CBZE. 4. The results suggest that the altered CYP3A4 enzyme activity and pharmacokinetics of CBZ might be attributed to DSN-mediated inhibition of CYP3A4 enzyme, which indicates pharmacokinetic interaction present between DSN and CBZ. Therefore, we conclude that DSN has an inhibiting effect on the metabolism and disposition of CBZ. [Mh] Termos MeSH primário: Anticonvulsivantes/metabolismo Carbamazepina/metabolismo Diosmina/metabolismo Interações Medicamentosas [Mh] Termos MeSH secundário: Adulto Meia-Vida Voluntários Saudáveis Seres Humanos Masculino Adulto Jovem [Pt] Tipo de publicação: CLINICAL TRIAL; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anticonvulsants); 33CM23913M (Carbamazepine); 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171018 [Lr] Data última revisão: 171018 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161004 [St] Status: MEDLINE [do] DOI: 10.1080/00498254.2016.1244368

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[PMID]: 27521821 [Au] Autor: Toledo RR; Santos MERC; Schnaider TB [Ad] Endereço: Professional Master's Program in Applied Health Sciences, Department of Surgery, Universidade do Vale do Sapucaí, Pouso Alegre, Brazil. Electronic address: renatortoledo@hotmail.com. [Ti] Título: Effect of Pycnogenol on the Healing of Venous Ulcers. [So] Source: Ann Vasc Surg;38:212-219, 2017 Jan. [Is] ISSN: 1615-5947 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: BACKGROUND: Venous ulcers are common complications of chronic venous insufficiency that result in severe physical and mental suffering to patients. The oral administration of diosmin/hesperidin has been used as adjuvant therapy in the treatment of chronic venous insufficiency. The purpose of this study was to evaluate and compare the effect of pycnogenol and diosmin/hesperidin on the healing of venous ulcers. METHODS: This longitudinal, prospective, randomized clinical trial was conducted with 30 adult patients with venous ulcers from a vascular surgery outpatient clinic of a university hospital. The patients were randomly allocated to 2 groups: Group 1 (n = 15) was treated with pycnogenol (50 mg orally, 3 times daily) and Group 2 (n = 15) was treated with diosmin/hesperidin (450/50 mg orally, twice daily). They were assessed every 15 days for 90 days. During follow-up visits, photo-documentation was obtained and the ulcer area and circumference of the affected limb were measured. Friedman's test and Mann-Whitney test were used to compare ulcer areas and circumference of affected limbs between and within groups at different time points. The level of significance was set at 5% (P < 0.05) for all tests. RESULTS: Both the pycnogenol and diosmin/hesperidin treatments had a similar effect on the healing of venous ulcers and led to a significant decrease in the circumference of affected limbs (P < 0.0001). CONCLUSION: The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin. [Mh] Termos MeSH primário: Diosmina/uso terapêutico Flavonoides/uso terapêutico Hesperidina/uso terapêutico Úlcera Varicosa/tratamento farmacológico Cicatrização/efeitos dos fármacos [Mh] Termos MeSH secundário: Administração Oral Idoso Brasil Diosmina/administração & dosagem Diosmina/efeitos adversos Esquema de Medicação Combinação de Medicamentos Feminino Flavonoides/administração & dosagem Flavonoides/efeitos adversos Hesperidina/administração & dosagem Hesperidina/efeitos adversos Seres Humanos Estudos Longitudinais Masculino Meia-Idade Estudos Prospectivos Fatores de Tempo Resultado do Tratamento Úlcera Varicosa/diagnóstico [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Drug Combinations); 0 (Flavonoids); 0 (pycnogenols); 7QM776WJ5N (Diosmin); E750O06Y6O (Hesperidin) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 171007 [Lr] Data última revisão: 171007 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160814 [St] Status: MEDLINE

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[PMID]: 27314532 [Au] Autor: Tsukanov YT; Nikolaichuk AI [Ad] Endereço: Department of Surgical Diseases, Omsk State Medical University, Omsk, Russia - yutsokanov@mail.ru. [Ti] Título: Orthostatic-loading-induced transient venous refluxes (day orthostatic loading test), and remedial effect of micronized purified flavonoid fraction in patients with telangiectasia and reticular vein. [So] Source: Int Angiol;36(2):189-196, 2017 Apr. [Is] ISSN: 1827-1839 [Cp] País de publicação: Italy [La] Idioma: eng [Ab] Resumo: BACKGROUND: Orthostatic loading can induce transient venous reflux (TVR). Among patients with telangiectasia and reticular varices, we determined the proportion that developed TVR after a day of orthostatic loading (DOL test), and investigated the remedial effects of micronized purified flavonoid fraction (MPFF). METHODS: All 96 patients enrolled in this study had telangiectasia and reticular varices. Patients underwent duplex scanning (DS) in the morning and evening, and vein diameters were measured. Patients with detectable evening TVR were treated daily with MPFF (Daflon® 1000 mg; Servier, Suresnes, France) for 90 days, and then reassessed. Patient quality of life (QOL) was evaluated using the Chronic Venous Insufficiency Questionnaire (CIVIQ-20). RESULTS: At baseline, patients had telangiectasia (45.8%), reticular varices (13.5%), or both (40.7%). TVR was absent in all patients in the morning but present in over half of them (55.2%) in the evening. All TVR patients complained of leg heaviness versus 16.3% of non-TVR patients. The great saphenous vein (GSV) diameters of patients with TVR were significantly greater than those without (Р<0.0001). After MPFF treatment, TVR was eliminated in most patients (92.5%). The GSV diameter in treated patients was significantly reduced from baseline (5.69-5.14 mm; Р=0.000001). The majority of patients (88.6%) no longer experienced leg heaviness, with 11.4% having reduced symptoms. QOL improved. CONCLUSIONS: More than half of the patients with telangiectasia and reticular varices experience TVR. TVRs can be exposed using the DOL test, which has no impact upon daily life. Daily MPFF (Daflon® 1000 mg) treatment over 90 days eliminated TVR, resolved venous symptoms, and improved QOL. [Mh] Termos MeSH primário: Diosmina/administração & dosagem Flavonoides/administração & dosagem Telangiectasia/tratamento farmacológico Varizes/tratamento farmacológico [Mh] Termos MeSH secundário: Adulto Feminino Seres Humanos Meia-Idade Qualidade de Vida Federação Russa Veia Safena/diagnóstico por imagem Veia Safena/efeitos dos fármacos Inquéritos e Questionários Telangiectasia/diagnóstico por imagem Ultrassonografia Varizes/diagnóstico por imagem Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Flavonoids); 7QM776WJ5N (Diosmin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170915 [Lr] Data última revisão: 170915 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160618 [St] Status: MEDLINE [do] DOI: 10.23736/S0392-9590.16.03708-1

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[PMID]: 27310527 [Au] Autor: González Ochoa A [Ad] Endereço: Clinedem Clinic, San Luis Rio Colorado, Mexico - alex8as2@yahoo.com.mx. [Ti] Título: Sulodexide and phlebotonics in the treatment of venous ulcer. [So] Source: Int Angiol;36(1):82-87, 2017 Feb. [Is] ISSN: 1827-1839 [Cp] País de publicação: Italy [La] Idioma: eng [Ab] Resumo: BACKGROUND: In the treatment of venous leg ulcers, vasoactive drugs such as diosmin-hesperidin micronized purified flavonoids (DH) and, more recently, sulodexide (SDX), have been used besides compression therapy and local measures. The purpose of this study was to investigate whether the combined administration of both SDX and DH is better than DH alone in the treatment of venous ulcers. METHODS: In an open-label, observational, non-parallel trial, 70 patients (90 venous ulcers) were treated with multi-layer bandaging, local measures and DH, 37 patients (50 ulcers) also received SDX, 33 patients (40 ulcers) without SDX were the control group. The evolution of leg ulcers and lipodermatosclerosis was evaluated by computerized imaging measurement. RESULTS: The initial clinical characteristics of both groups were similar. Ulcer size showed a faster reduction in the group receiving SDX (P<0.01). With SDX, all of the ulcers were healed by week 12, in the control group, all ulcers were healed at week 21 (P<0.01 between groups). Lipodermatosclerosis improved in both groups, but it decreased faster in the SDX group. No adverse effects attributed to the medications were seen in either group. CONCLUSIONS: The combined administration of SDX and DH was effective in accelerating ulcer healing, controlling pain and improving lipodermatosclerosis. [Mh] Termos MeSH primário: Dermatite/tratamento farmacológico Diosmina/administração & dosagem Glicosaminoglicanos/administração & dosagem Hesperidina/administração & dosagem Esclerodermia Localizada/tratamento farmacológico Úlcera Varicosa/tratamento farmacológico Cicatrização/efeitos dos fármacos [Mh] Termos MeSH secundário: Adulto Idoso Quimioterapia Combinada Feminino Seres Humanos Masculino México Meia-Idade Resultado do Tratamento [Pt] Tipo de publicação: CONTROLLED CLINICAL TRIAL; JOURNAL ARTICLE; OBSERVATIONAL STUDY [Nm] Nome de substância: 0 (Glycosaminoglycans); 75HGV0062C (glucuronyl glucosamine glycan sulfate); 7QM776WJ5N (Diosmin); E750O06Y6O (Hesperidin) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170523 [Lr] Data última revisão: 170523 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160617 [St] Status: MEDLINE [do] DOI: 10.23736/S0392-9590.16.03718-4

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