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[PMID]:28974426
[Au] Autor:Chatzikonstantinou AV; Chatziathanasiadou MV; Ravera E; Fragai M; Parigi G; Gerothanassis IP; Luchinat C; Stamatis H; Tzakos AG
[Ad] Endereço:Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece; Department of Biological Applications and Technologies, University of Ioannina, 45110 Ioannina, Greece.
[Ti] Título:Enriching the biological space of natural products and charting drug metabolites, through real time biotransformation monitoring: The NMR tube bioreactor.
[So] Source:Biochim Biophys Acta;1862(1):1-8, 2018 01.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Natural products offer a wide range of biological activities, but they are not easily integrated in the drug discovery pipeline, because of their inherent scaffold intricacy and the associated complexity in their synthetic chemistry. Enzymes may be used to perform regioselective and stereoselective incorporation of functional groups in the natural product core, avoiding harsh reaction conditions, several protection/deprotection and purification steps. METHODS: Herein, we developed a three step protocol carried out inside an NMR-tube. 1st-step: STD-NMR was used to predict the: i) capacity of natural products as enzyme substrates and ii) possible regioselectivity of the biotransformations. 2nd-step: The real-time formation of multiple-biotransformation products in the NMR-tube bioreactor was monitored in-situ. 3rd-step: STD-NMR was applied in the mixture of the biotransformed products to screen ligands for protein targets. RESULTS: Herein, we developed a simple and time-effective process, the "NMR-tube bioreactor", that is able to: (i) predict which component of a mixture of natural products can be enzymatically transformed, (ii) monitor in situ the transformation efficacy and regioselectivity in crude extracts and multiple substrate biotransformations without fractionation and (iii) simultaneously screen for interactions of the biotransformation products with pharmaceutical protein targets. CONCLUSIONS: We have developed a green, time-, and cost-effective process that provide a simple route from natural products to lead compounds for drug discovery. GENERAL SIGNIFICANSE: This process can speed up the most crucial steps in the early drug discovery process, and reduce the chemical manipulations usually involved in the pipeline, improving the environmental compatibility.
[Mh] Termos MeSH primário: Reatores Biológicos
Lipase/metabolismo
Espectroscopia de Ressonância Magnética/métodos
Quercetina/farmacologia
Quercetina/farmacocinética
[Mh] Termos MeSH secundário: Biotransformação
Lipase/química
Quercetina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9IKM0I5T1E (Quercetin); EC 3.1.1.- (Novozyme 435); EC 3.1.1.3 (Lipase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE


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[PMID]:28748727
[Au] Autor:Yan S; Pan S; Ji J
[Ad] Endereço:a School of Petrochemical Engineering , Changzhou University , Changzhou , PR China.
[Ti] Título:Silk fabric dyed with extract of sophora flower bud.
[So] Source:Nat Prod Res;32(3):308-315, 2018 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study analysed the use of sophora flower bud extract for dyeing and the resulting colour character and fastness of dyed silk fabric. The pigment composition on the silk fabric and recycling of this extract were also studied. The results indicated that the dyed silk fabric possessed good washing, rubbing and perspiration fastness, and the pigment composition on the silk fabric was mainly rutin and quercetin. The average recovery rate of the dye was 55.00%. These results demonstrate that the sophora flower bud extract is an effective natural dye.
[Mh] Termos MeSH primário: Corantes/química
Extratos Vegetais/química
Seda/química
Sophora/química
Têxteis
[Mh] Termos MeSH secundário: Precipitação Química
Cromatografia Líquida de Alta Pressão
Corantes/análise
Flores/química
Espectroscopia de Ressonância Magnética
Extratos Vegetais/análise
Quercetina/análise
Rutina/análise
Espectroscopia de Infravermelho com Transformada de Fourier
Têxteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Plant Extracts); 0 (Silk); 5G06TVY3R7 (Rutin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1359170


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[PMID]:29355544
[Au] Autor:Li X; Zhou N; Wang J; Liu Z; Wang X; Zhang Q; Liu Q; Gao L; Wang R
[Ad] Endereço:Key Laboratory of Pharmacology, Chifeng University, Hongshan, Chifeng, Inner Mongolia 024000, China.
[Ti] Título:Quercetin suppresses breast cancer stem cells (CD44 /CD24 ) by inhibiting the PI3K/Akt/mTOR-signaling pathway.
[So] Source:Life Sci;196:56-62, 2018 Mar 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Cancer stem cells (CSCs) are considered the prime source of cancer recurrence, metastasis, and progression and represent important targets for developing novel anticancer agents and therapeutic strategies. The aim of this study was to investigate the effect of treating breast CSCs with the anticancer flavonoid, quercetin. MAIN METHODS: We examined changes in the cluster of differentiation CD44 /CD24 CSC population and behavior using the breast cancer cell line MCF-7. KEY FINDINGS: Our results indicated that cell viability, clone formation, mammosphere generation, and nude mice tumor metastasis were inhibited in the CD44 /CD24 population and that MCF-7 cells exhibited G1-phase arrest after quercetin treatment. Additionally, CyclinD1 and B cell lymphoma-2 expression were suppressed and Bcl-2-like protein-4 expression was enhanced after quercetin treatment. We also observed that estrogen receptor α and phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling were downregulated concurrently with the inhibition of CD44 /CD24 viability and clone formation. Our findings suggested that quercetin treatment promoted weaker malignant activity associated with CSCs relative to that observed in normal cancer cells through its inhibition of the PI3K/Akt/mTOR-signaling pathway. SIGNIFICANCE: These results indicated that CSCs are potential therapeutic targets for quercetin treatment of breast cancer.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Antígeno CD24/efeitos dos fármacos
Receptores de Hialuronatos/efeitos dos fármacos
Proteína Oncogênica v-akt/antagonistas & inibidores
Fosfatidilinositol 3-Quinases/antagonistas & inibidores
Quercetina/farmacologia
Transdução de Sinais/efeitos dos fármacos
Serina-Treonina Quinases TOR/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Feminino
Fase G1/efeitos dos fármacos
Seres Humanos
Células MCF-7
Camundongos Nus
Proteínas Proto-Oncogênicas c-bcl-2/antagonistas & inibidores
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (CD24 Antigen); 0 (CD44 protein, human); 0 (Hyaluronan Receptors); 0 (Proto-Oncogene Proteins c-bcl-2); 9IKM0I5T1E (Quercetin); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.1 (MTOR protein, human); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.11.1 (Oncogene Protein v-akt)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180123
[St] Status:MEDLINE


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[PMID]:29180863
[Au] Autor:Liu K; Chen W; Yang T; Wen B; Ding D; Keidar M; Tang J; Zhang W
[Ad] Endereço:College of Pharmacy, Weifang Medical University, Weifang.
[Ti] Título:Paclitaxel and quercetin nanoparticles co-loaded in microspheres to prolong retention time for pulmonary drug delivery.
[So] Source:Int J Nanomedicine;12:8239-8255, 2017.
[Is] ISSN:1178-2013
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:High drug resistance, poor water solubility, short half-life, and low local drug concentration are obstacles for successful delivery of chemotherapeutic drugs for lung cancer. A new method involving the use of nanoparticles (NPs) for pulmonary delivery is proposed. However, use of NPs is limited by the particle size range for pulmonary drug delivery considering that NPs cannot be deposited directly into the lungs. NPs polymerized into microspheres (polymeric microspheres, PMs) will result in suitable particle sizes and retain the advantages of nanodrugs after redispersion when applied in pulmonary delivery. We report the development of novel NPs in the form of PMs loaded with paclitaxel (PTX) and quercetin (QUE) double drugs based on the synthesis of oleic acid-conjugated chitosan (OA-CTS) for pulmonary delivery. This approach is aimed toward prolonging PTX retention time in the presence of QUE and bypassing P-glycoprotein drug efflux pumps. NPs loaded with PTX or QUE were prepared with 11% substitution degree using OA-CTS as the carrier by ionic cross-linking method, which NPs loaded with PTX or QUE were used in the preparation of PMs by spray-drying. The diameters of the PMs ranged from 1 to 5 µm which had uniform size range. Scanning electron microscopy showed that PMs were polymers formed by a large number of NPs and readily redispersed (after redispersion, size of NPs ranged between 250 and 350 nm) in water within 1 h. PMs displayed slow-release characteristics at pH 4.5 and 7.4. The in vivo pharmacokinetic and biodistribution studies suggested that PMs exhibit prolonged circulation time and a markedly high accumulation in the lung. The obtained results indicate that PMs can serve as a promising pulmonary delivery system for combined pharmacotherapy using hydrophobic anticancer drugs.
[Mh] Termos MeSH primário: Pulmão/efeitos dos fármacos
Nanopartículas/química
Paclitaxel/administração & dosagem
Quercetina/administração & dosagem
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo
Animais
Antineoplásicos/administração & dosagem
Quitosana/química
Sistemas de Liberação de Medicamentos
Liberação Controlada de Fármacos
Feminino
Meia-Vida
Masculino
Microesferas
Ácido Oleico/química
Paclitaxel/farmacocinética
Tamanho da Partícula
Quercetina/farmacocinética
Ratos Wistar
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (ATP-Binding Cassette, Sub-Family B, Member 1); 0 (Antineoplastic Agents); 2UMI9U37CP (Oleic Acid); 9012-76-4 (Chitosan); 9IKM0I5T1E (Quercetin); P88XT4IS4D (Paclitaxel)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE
[do] DOI:10.2147/IJN.S147028


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[PMID]:29351879
[Au] Autor:Szopa A; Starzec A; Ekiert H
[Ad] Endereço:Chair and Department of Pharmaceutical Botany, Jagiellonian University, Collegium Medicum, ul. Medyczna 9, 30-688 Kraków, Poland. Electronic address: a.szopa@uj.edu.pl.
[Ti] Título:The importance of monochromatic lights in the production of phenolic acids and flavonoids in shoot cultures of Aronia melanocarpa, Aronia arbutifolia and Aronia נprunifolia.
[So] Source:J Photochem Photobiol B;179:91-97, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Shoot cultures of Aronia melanocarpa, A. arbutifolia and A. × prunifolia were maintained on Murashige and Skoog medium with 1 mg/l each of BA and NAA under monochromatic lights (far-red, red, blue lights, UV-A-irradiation), in darkness, and under white light (control). HPLC-DAD analyses of 19 phenolic acids and 11 flavonoids in methanolic extracts from the shoots revealed in all of them the presence of three depsides (chlorogenic, neochlorogenic and rosmarinic acids), protocatechuic acid, four flavonoid glycosides (cynaroside, quercitrin, hyperoside and rutoside), and additionally, in A. arbutifolia, 3,4-dihydroxyphenylacetic acid. Depending on light quality, the total amounts of these metabolites increased 1.8-5.9 times, reaching maximum values under blue light: 527.40 and 144.61 mg 100 g DW (A. melanocarpa), 543.27 and 85.82 mg 100 g DW (A. arbutifolia) and 1615.18 and 220.65 mg 100 g DW (A. × prunifolia), respectively. The maximum total amounts were 1.3-3.6 times higher than under white light. The quantities of individual metabolites changed from 1.2 to 11.0 times, with high amounts of neochlorogenic acid and quercitrin in A. melanocarpa (243.35 and 75.64 mg 100 g DW), and of chlorogenic and rosmarinic acids and quercitrin in A. arbutifolia (236.52, 219.35 and 51.01 mg 100 g DW). Extremely high amounts of depsides (418.83, 644.68, 548.86 mg 100 g DW) and quercitrin (165.88 mg 100 g DW) were produced in cultures of the hybrid - A. × prunifolia. The results are potentially useful for practical applications. This is the first report documented the importance of light quality on the production of phenolic acids and flavonoids in three aronia in vitro cultures.
[Mh] Termos MeSH primário: Flavonoides/metabolismo
Hidroxibenzoatos/metabolismo
Luz
Photinia/efeitos da radiação
[Mh] Termos MeSH secundário: Biomassa
Ácido Clorogênico/análise
Ácido Clorogênico/metabolismo
Cromatografia Líquida de Alta Pressão
Cinamatos/análise
Cinamatos/metabolismo
Depsídeos/análise
Depsídeos/metabolismo
Flavonoides/análise
Hidroxibenzoatos/análise
Photinia/química
Photinia/metabolismo
Brotos de Planta/química
Brotos de Planta/metabolismo
Brotos de Planta/efeitos da radiação
Quercetina/análogos & derivados
Quercetina/análise
Quercetina/metabolismo
Raios Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Depsides); 0 (Flavonoids); 0 (Hydroxybenzoates); 29656-58-4 (phenolic acid); 2Y8906LC5P (quercitrin); 318ADP12RI (Chlorogenic Acid); 9IKM0I5T1E (Quercetin); MQE6XG29YI (rosmarinic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180121
[St] Status:MEDLINE


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[PMID]:29334625
[Au] Autor:Liu Y; Fang S; Yang W; Shang X; Fu X
[Ad] Endereço:College of Forestry, Nanjing Forestry University, Nanjing 210037, PR China.
[Ti] Título:Light quality affects flavonoid production and related gene expression in Cyclocarya paliurus.
[So] Source:J Photochem Photobiol B;179:66-73, 2018 Feb.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Understanding the responses of plant growth and secondary metabolites to differential light conditions is very important to optimize cultivation conditions of medicinal woody plants. As a highly valued and multiple function tree species, Cyclocarya paliurus is planted and managed for timber production and medical use. In this study, LED-based light including white light (WL), blue light (BL), red light (RL), and green light (GL) were used to affect leaf biomass production, flavonoid accumulation and related gene expression of one-year C. paliurus seedlings in controlled environments. After the treatments of 60 days, the highest leaf biomass appeared in the treatment of WL, while the lowest leaf biomass was found under GL. Compared to WL, the total flavonoid contents of C. paliurus leaves were significantly higher in BL, RL, and GL, but the highest values of selected flavonoids (kaempferol, isoquercitrin and quercetin) were observed under BL. Furthermore, the greatest yields of total and selected flavonoids in C. paliurus leaves per seedling were also achieved under BL, indicating that blue light was effective for inducing the production of flavonoids in C. paliurus leaves. Pearson's correlation analysis showed that there were significantly positive correlations between leaf flavonoid content and relative gene expression of key enzymes (phenylalanine ammonia lyase, PAL; 4-coumaroyl CoA-ligase, 4CL; and chalcone synthase, CHS) in the upstream, which converting phenylalanine into the flavonoid skeleton of tetrahydroxy chalcone. It is concluded that manipulating light quality may be potential mean to achieve the highest yields of flavonoids in C. paliurus cultivation, however this needs to be further verified by more field trials.
[Mh] Termos MeSH primário: Flavonoides/metabolismo
Expressão Gênica/efeitos da radiação
Juglandaceae/efeitos da radiação
Luz
[Mh] Termos MeSH secundário: Biomassa
Flavonoides/química
Juglandaceae/metabolismo
Quempferóis/química
Quempferóis/metabolismo
Folhas de Planta/química
Folhas de Planta/metabolismo
Folhas de Planta/efeitos da radiação
Quercetina/análogos & derivados
Quercetina/química
Quercetina/metabolismo
Plântulas/química
Plântulas/metabolismo
Plântulas/efeitos da radiação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Kaempferols); 0YX10VRV6J (isoquercitrin); 731P2LE49E (kaempferol); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180116
[St] Status:MEDLINE


  7 / 7679 MEDLINE  
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[PMID]:29324796
[Au] Autor:Li XM; Liu J; Pan FF; Shi DD; Wen ZG; Yang PL
[Ad] Endereço:Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Quercetin and aconitine synergistically induces the human cervical carcinoma HeLa cell apoptosis via endoplasmic reticulum (ER) stress pathway.
[So] Source:PLoS One;13(1):e0191062, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Up till now, studies have not been conducted on how the combination of Quercetin (Q), Aconitine (A) and apoptosis induction affects human cervical carcinoma HeLa cells. The result of our findings shows that the combination of Q and A (QA) is capable of synergistically inhibiting the proliferation of HeLa cells in a number of concentrations. QA synergistically inhibits the proliferation of MDR1 gene in the HeLa cells. It is concluded based on our result that QA induces apoptosis and ER stress just as QA-induced ER stress pathway may mediate apoptosis by upregulating mRNA expression levels of eIF2α, ATF4, IRE1, XBP1, ATF6, PERK and CHOP in the HeLa cells. The up-regulating of mRNA expression level of GRP78 and activation of UPR are a molecular basis of QA-induced ER stress.
[Mh] Termos MeSH primário: Aconitina/farmacologia
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Quercetina/farmacologia
Neoplasias do Colo do Útero/patologia
[Mh] Termos MeSH secundário: Subfamília B de Transportador de Cassetes de Ligação de ATP/genética
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/genética
Feminino
Células HeLa
Seres Humanos
Marcação In Situ das Extremidades Cortadas
Espécies Reativas de Oxigênio/metabolismo
Resposta a Proteínas não Dobradas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ABCB1 protein, human); 0 (ATP Binding Cassette Transporter, Sub-Family B); 0 (Reactive Oxygen Species); 9IKM0I5T1E (Quercetin); X8YN71D5WC (Aconitine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191062


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[PMID]:29315311
[Au] Autor:Hwang HV; Tran DT; Rebuffatti MN; Li CS; Knowlton AA
[Ad] Endereço:Molecular & Cellular Cardiology, Cardiovascular Division, Department of Internal Medicine, University of California-Davis, Davis, CA, United States of America.
[Ti] Título:Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells.
[So] Source:PLoS One;13(1):e0190374, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:NEW AND NOTEWORTHY: Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
[Mh] Termos MeSH primário: Senescência Celular/efeitos dos fármacos
Endotélio Vascular/efeitos dos fármacos
Quercetina/análogos & derivados
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Adulto
Proliferação Celular/efeitos dos fármacos
Endotélio Vascular/citologia
Feminino
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
8O1CR18L82 (hyperoside); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190374


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[PMID]:29249156
[Au] Autor:Ting Y; Chang WT; Shiau DK; Chou PH; Wu MF; Hsu CL
[Ad] Endereço:Graduate Institute of Food Science and Technology, National Taiwan University , Taipei, Taiwan.
[Ti] Título:Antiobesity Efficacy of Quercetin-Rich Supplement on Diet-Induced Obese Rats: Effects on Body Composition, Serum Lipid Profile, and Gene Expression.
[So] Source:J Agric Food Chem;66(1):70-80, 2018 Jan 10.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The antiobesity effects of quercetin-rich supplement (QRS), which contain quercetin, lycopene, taurine, and litchi flower extract, on a high-fat diet (HFD)-induced obese rats were investigated. The rats that consume HFD with QRS (185 mg/kg rat) have significantly modulated the final body weights [490 ± 11 (HFD) → 441 ± 11 (HFD+QRS) g], total body fat [112.9 ± 4.5 (HFD) → 86.6 ± 5.7 (HFD+QRS) g], liver weights [14.8 ± 0.4 (HFD) → 12.6 ± 0.4 (HFD+QRS) g/rat], and the serum TG [102.5 ± 7.3 (HFD) → 90.7 ± 6.5 (HFD+QRS) mg/dL] to a level that resembled the regular diet-consumed rats (p < 0.05). The excretion of lipid in the faeces augmented in QRS groups as compared with the nonsupplemented HFD group [faecal total lipid: 62.43 ± 2.80 (HFD) → 73.15 ± 0.88 (HFD+QRS) mg/g dried faeces, p < 0.05]. In the histological analysis, quercetin-rich formulation supplemented groups presented a much less lipid accumulation and smaller size of adipocytes. Moreover, a decreased serum thiobarbituric acid reactive substances [1.55 ± 0.17 (HFD) → 0.78 ± 0.04 (HFD+QRS) nmol MDA eq/mL serum] increased levels of serum Trolox equivalent antioxidant capacity [3.89 ± 0.08 (HFD) → 6.46 ± 0.20 (HFD+QRS) µmol/mL serum], and more active hepatic antioxidant enzymes were observed in the supplemented groups (p < 0.05). The result of this work is a good demonstration of how a combination of bioactive compounds could work synergistically and become very effective in disease prevention.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/farmacologia
Composição Corporal/efeitos dos fármacos
Lipídeos/sangue
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Tecido Adiposo/efeitos dos fármacos
Animais
Peso Corporal/efeitos dos fármacos
Dieta Hiperlipídica/efeitos adversos
Suplementos Nutricionais
Regulação da Expressão Gênica/efeitos dos fármacos
Metabolismo dos Lipídeos/efeitos dos fármacos
Masculino
Obesidade/etiologia
Obesidade/genética
Obesidade/prevenção & controle
Tamanho do Órgão/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Lipids); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b03551


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[PMID]:29287782
[Au] Autor:Liaquat L; Batool Z; Sadir S; Rafiq S; Shahzad S; Perveen T; Haider S
[Ad] Endereço:Neurochemistry and Biochemical Neuropharmacology Research Unit, Department of Biochemistry, University of Karachi, Karachi 75270, Pakistan.
[Ti] Título:Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats.
[So] Source:Life Sci;194:213-223, 2018 Feb 01.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Free radical mediated neurotoxicity is a leading cause of neurodegenerative disorders. Neurodegeneration due to oxidative stress can produce cognitive dysfunctions. Flavonoids and curcuminoids are naturally occurring polyphenolic compounds that display a variety of therapeutic importance against oxidative stress. MAIN METHODS: This study was designed to assess potential role of polyphenolic compounds in neurocognitive functions and prevention against oxidative stress. For this purpose, young rats were orally treated with naringenin (NAR), curcumin (CUR) and quercetin (QUE) at a dose of 50mg/kg, 200mg/kg and 50mg/kg respectively for 16days. At 4th day of drug administration cognitive functions were monitored by Morris water maze (MWM) test. In MWM cognitive functions in terms of learning acquisition (1h after training), retention (24h after training), memory extinction (4days after training), and reconsolidation (8 and 12days after training) were monitored. Biochemical and neurochemical analysis were done in whole brain. KEY FINDINGS: Treatment of NAR, CUR and QUE significantly enhanced learning acquisition, memory retention and reconsolidation and prevented memory extinction. Treatment of NAR and QUE prevented the alteration of brain antioxidant defence system by enhancing antioxidant enzyme activities and increasing antioxidant compound concentration. Oxidative stress in terms of lipid peroxidation was significantly prevented in treated rats. Serotonergic and cholinergic improvement was also found in treated rats. SIGNIFICANCE: The present study therefore provides biological evidence supporting the usefulness of these polyphenolic compounds in daily life for improvement of cognitive abilities and hence may have a potential role in the management of dementia and related disorders.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Cognição/efeitos dos fármacos
Curcumina/farmacologia
Flavanonas/farmacologia
Memória/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Acetilcolinesterase/metabolismo
Animais
Antioxidantes/administração & dosagem
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Colinérgicos/farmacologia
Curcumina/administração & dosagem
Flavanonas/administração & dosagem
Masculino
Quercetina/administração & dosagem
Ratos
Ratos Wistar
Serotonina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cholinergic Agents); 0 (Flavanones); 333DO1RDJY (Serotonin); 9IKM0I5T1E (Quercetin); EC 3.1.1.7 (Acetylcholinesterase); HN5425SBF2 (naringenin); IT942ZTH98 (Curcumin); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE



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