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[PMID]:28748727
[Au] Autor:Yan S; Pan S; Ji J
[Ad] Endereço:a School of Petrochemical Engineering , Changzhou University , Changzhou , PR China.
[Ti] Título:Silk fabric dyed with extract of sophora flower bud.
[So] Source:Nat Prod Res;32(3):308-315, 2018 Feb.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study analysed the use of sophora flower bud extract for dyeing and the resulting colour character and fastness of dyed silk fabric. The pigment composition on the silk fabric and recycling of this extract were also studied. The results indicated that the dyed silk fabric possessed good washing, rubbing and perspiration fastness, and the pigment composition on the silk fabric was mainly rutin and quercetin. The average recovery rate of the dye was 55.00%. These results demonstrate that the sophora flower bud extract is an effective natural dye.
[Mh] Termos MeSH primário: Corantes/química
Extratos Vegetais/química
Seda/química
Sophora/química
Têxteis
[Mh] Termos MeSH secundário: Precipitação Química
Cromatografia Líquida de Alta Pressão
Corantes/análise
Flores/química
Espectroscopia de Ressonância Magnética
Extratos Vegetais/análise
Quercetina/análise
Rutina/análise
Espectroscopia de Infravermelho com Transformada de Fourier
Têxteis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coloring Agents); 0 (Plant Extracts); 0 (Silk); 5G06TVY3R7 (Rutin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1359170


  2 / 2406 MEDLINE  
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[PMID]:28468251
[Au] Autor:Han X; Xue X; Zhao Y; Li Y; Liu W; Zhang J; Fan S
[Ad] Endereço:Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Peking Union Medical College and Chinese Academy of Medical Science, Tianjin 300192, China. hanxiaodan1202@gmail.com.
[Ti] Título:Rutin-Enriched Extract from Coriandrum sativum L. Ameliorates Ionizing Radiation-Induced Hematopoietic Injury.
[So] Source:Int J Mol Sci;18(5), 2017 Apr 29.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Hematopoietic injury is a major cause of mortality in radiation accidents and a primary side effect in patients undergoing radiotherapy. Ionizing radiation (IR)-induced myelosuppression is largely attributed to the injury of hematopoietic stem and progenitor cells (HSPCs). Coriander is a culinary herb with multiple pharmacological effects and has been widely used in traditional medicine. In this study, flavonoids were identified as the main component of coriander extract with rutin being the leading compound (rutin-enriched coriander extract; RE-CE). We evaluated the radioprotective effect of RE-CE against IR-induced HSPCs injury. Results showed that RE-CE treatment markedly improved survival, ameliorated organ injuries and myelosuppression, elevated HSPCs frequency, and promoted differentiation and proliferation of HSPCs in irradiated mice. The protective role of RE-CE in hematopoietic injury is probably attributed to its anti-apoptotic and anti-DNA damage effect in irradiated HSPCs. Moreover, these changes were associated with reduced reactive oxygen species (ROS) and enhanced antioxidant enzymatic activities in irradiated HSPCs. Collectively, these findings demonstrate that RE-CE is able to ameliorate IR-induced hematopoietic injury partly by reducing IR-induced oxidative stress.
[Mh] Termos MeSH primário: Coriandrum/química
Células-Tronco Hematopoéticas/efeitos dos fármacos
Células-Tronco Hematopoéticas/efeitos da radiação
Lesões por Radiação/tratamento farmacológico
Protetores contra Radiação/uso terapêutico
Rutina/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
Apoptose/efeitos da radiação
Células Cultivadas
Dano ao DNA/efeitos dos fármacos
Células-Tronco Hematopoéticas/metabolismo
Células-Tronco Hematopoéticas/patologia
Masculino
Camundongos Endogâmicos C57BL
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/efeitos da radiação
Lesões por Radiação/genética
Lesões por Radiação/metabolismo
Lesões por Radiação/patologia
Radiação Ionizante
Protetores contra Radiação/química
Espécies Reativas de Oxigênio/metabolismo
Rutina/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiation-Protective Agents); 0 (Reactive Oxygen Species); 5G06TVY3R7 (Rutin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE


  3 / 2406 MEDLINE  
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[PMID]:29381299
[Au] Autor:Balakina AS; Trusov NV; Aksenov IV; Guseva GV; Kravchenko LV; Tutelyan VA
[Ti] Título:[The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride].
[So] Source:Vopr Pitan;85(5):28-35, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The purpose of the study was to determine the effects of rutin (R) and hesperidin (Hes), the main representatives of two most studied subclasses of flavonoids - flavonols and flavanones, on the expression of prototypical Nrf2 and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride (CCl4). Investigations were carried out on 5 groups of male Wistar rats with the initial body weight (b.w.) 180-200 g (n=40). Rats of the control group and the 1st experimental group received for 14 days the semisynthetic diet, rats of the 2nd experimental group - the same diet plus R (400 mg/kg b.w.), the animals of the 3rd experimental group received the diet with Hes in the same amount, of the 4th experimental group - diet with R (400 mg/kg b.w.) and Hes (400 mg/kg b.w.). Animals of the experimental groups 24 hours before the end of experiment were injected intraperitoneally CCl4 at a dose of 0.5 ml/kg b.w. in olive oil; rats of the control group were injected equal amount of olive oil. For gene expression assessment the mRNA content of NAD(P)H-quinone oxidoreductase (NQO1), heme oxygenase-1 (Hmox1), Nrf2 (Nrf2), AhR (AhR), CYP1A1, CYP1A2, CYP3A1 and ß-actin (Actb) in rat liver was determined by real-time RT-PCR. The results showed that in rats intoxicated with CCl4, enrichment of the diet with R, but not with Hes, led to a significant increase in the expression of genes Hmox1, NQO1 and CYP3A1. Combined intake of R and Hes with the diet led to additivity of their action on the expression of Hmox1 gene and to synergism in the effect on the expression of genes NQO1 and CYP3A1. A moderate increase in the levels of expression of AhR and CYP1A2 genes as compared to their expression in rats treated with CCl4 only, CCl4 and R or CCl4 and Hes has been noted. Thus, for the first time on the model of oxidative stress in rats the data have been obtained showing at the gene expression level a synergism of action of two flavonoids - R and Hes, widely present in the daily human diet.
[Mh] Termos MeSH primário: Fatores de Transcrição Hélice-Alça-Hélice Básicos/metabolismo
Intoxicação por Tetracloreto de Carbono/metabolismo
Citocromo P-450 CYP3A/biossíntese
Regulação da Expressão Gênica/efeitos dos fármacos
Hesperidina/farmacologia
Fígado/metabolismo
Fator 2 Relacionado a NF-E2/metabolismo
Receptores de Hidrocarboneto Arílico/metabolismo
Rutina/farmacologia
[Mh] Termos MeSH secundário: Animais
Intoxicação por Tetracloreto de Carbono/patologia
Fígado/patologia
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ahr protein, rat); 0 (Basic Helix-Loop-Helix Transcription Factors); 0 (NF-E2-Related Factor 2); 0 (Nfe2l2 protein, rat); 0 (Receptors, Aryl Hydrocarbon); 5G06TVY3R7 (Rutin); E750O06Y6O (Hesperidin); EC 1.14.14.1 (Cyp3a1 protein, rat); EC 1.14.14.1 (Cytochrome P-450 CYP3A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  4 / 2406 MEDLINE  
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[PMID]:29378094
[Au] Autor:Thushina EN; Mustafina OK; Kravchenko LV; Balakina AS; Alekseeva IA; Riger NA
[Ti] Título:[Effect of minor bioactive food substances ­ rutin and hesperidin in their separate and combined alimentary arrives on the immune system of rats and the activity of nuclear factor NF-kB liver cells].
[So] Source:Vopr Pitan;84(6):19-29, 2015.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The effect of rutin and hesperidin in their separate and combined admission to the immune system and the activity of nuclear factor NF-kB of rat liver cells has been investigated. Wistar male rats with an initial body weight of 224­225 g were divided into 4 groups of 6 rats in each. The rats of the 1st group (control) received a complete semi-synthetic diet, rats in group 2 ­ the same diet supplemented with rutine (400 mg/kg b.w.); the rats of group 3 ­ with the addition of hesperidin (400 mg/kg bw); group 4 ­ with the addition of rutin and hesperidin (400 mg/kg b.w. each) for 14 days. Animals received feed in free access mode in an amount of 25­30 g per rat per day, that corresponded to 15 g of dry formula. Animals received water also in free access. It has been found that rutin and hesperidin, included in the diet of rats both alone (groups 2 and 3) and together (group 4), have immunomodulatory impact which is a reduce of lymphocyte relative content [1st gr. ­ 70.55±1.58%, 2nd gr. ­ 63.62±2.85%, 3rd gr. ­ 62.03±3.16% (p1­3<0.05), 4th gr. ­ 65.75±1.08% (p1­4<0.05)] and an increase of percentage of neutrophil leukocytes [1st gr ­ 19.98±0.97%, 2nd gr. ­ 25.35±3.14%, 3rd gr. ­ 28.27±3.30% (p1­3<0.05), 4th gr. ­ 24.15±1.52% (p1­4<0.05)] and NK-cells in the peripheral blood [1st gr. ­ 3.29±0.45%, 2nd gr. ­ 6.91±0.70% (p1­2<0.05), 3rd gr. ­ 5.88±0.79% (p1­3<0.05), 4th gr. ­ 4.64±0.32% (p1­4<0.05)], that can be considered as a shift in the direction of innate immunity factors. In addition, the combined effect of high doses of rutin and hesperidin led to a change in erythrocyte parameters: an increase in the average volume of red blood cells [1st gr. ­ 56.00±1.06 fl, 2nd gr. ­ 56.67±0.42 fl, 3rd gr. ­ 58.50± 0.99 fl, 4th gr. ­ 59.50±0.99 fl (p1­4<0.05)], and the average content of hemoglobin [1st gr. ­ 18.97±0.45 pg, 2nd gr. ­ 19.10±0.19 pg, 3rd gr. ­ 19.73± 0.32 pg, 4th gr. ­ 20.08±0.33 pg (p1­4=0.07)], as well as increase in the level of TGF-ß1 in peripheral blood [1st gr. ­ 15.55±2.13 ng/ml, 2nd gr. ­ 14.81± 2.36 ng/ml, 3rd gr. ­ 17.02±2.53 ng/ml, 4th gr. ­ 22.14±2.29 ng/ml (p1­4<0.05)] and the expression of nuclear factor NF-kB in the liver cells [1st gr. ­ 16.10± 0.60 ng/ml; 2nd gr. ­ 15.14±2.28 ng/ml; 3rd gr. ­ 15.85±2.09 ng/ml; 4th gr. ­ 20.49±1.68 ng/ml (p1­4<0.05)].
[Mh] Termos MeSH primário: Aditivos Alimentares/farmacologia
Hesperidina/farmacologia
Imunidade Inata/efeitos dos fármacos
Leucócitos/imunologia
Fígado/imunologia
NF-kappa B/imunologia
Rutina/farmacologia
[Mh] Termos MeSH secundário: Animais
Leucócitos/citologia
Fígado/citologia
Masculino
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Food Additives); 0 (NF-kappa B); 5G06TVY3R7 (Rutin); E750O06Y6O (Hesperidin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


  5 / 2406 MEDLINE  
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[PMID]:28454506
[Au] Autor:Pandey A; Kaushik A; Wanjari M; Dey YN; Jaiswal BS; Dhodi A
[Ad] Endereço:a Department of Pharmaceutical Sciences , IFTM University , Moradabad , India.
[Ti] Título:Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves.
[So] Source:Pharm Biol;55(1):1688-1697, 2017 12.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae), commonly called "Bui";, is a medicinal plant of the arid region. It is used for the treatment of inflammatory disorders, such as rheumatic pain, and healing of wounds, which are associated with oxidative stress. OBJECTIVE: The present study evaluated the antioxidant potential of Aerva pseudotomentosa leaves by in vitro models and its anti-inflammatory effect in rats. MATERIAL AND METHODS: The aqueous extract (APAE) was analyzed by HPTLC and HPLC. The antioxidant effect of APAE was evaluated by various in vitro methods [DPPH (1, 1-diphenyl-2-picryl-hydrazil) and hydrogen peroxide free radical scavenging, reducing power, and anti-lipid peroxidation assays]. Anti-inflammatory effect was studied in carrageenan and formalin-induced paw oedema models in rats. APAE (200 and 400 mg/kg) and standard drug, indomethacin (10 mg/kg), were administered orally 1 h before carrageenan/formalin administration and inflammation was noted up to 5 h. RESULTS: HPLC analysis of APAE revealed the presence of rutin. APAE showed significant scavenging effect on DPPH (IC 49.37 µ g/mL) and peroxide (IC 288.2 µ g/mL) radicals. The extract exhibited reducing potential and inhibition of lipid peroxidation. APAE treatment significantly attenuated mean increase in paw volume and exhibited inhibition of paw oedema in both in vivo models with inhibition of 45.11% and 49.42%, respectively at 5 h. DISCUSSION AND CONCLUSION: APAE exhibited in vitro antioxidant and anti-inflammatory activities. Anti-inflammatory effect of APAE may be attributed to its antioxidant potential, due to the presence of rutin and other phenolics. This study substantiates folk use of leaves in inflammatory disorders.
[Mh] Termos MeSH primário: Amaranthaceae/química
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Edema/tratamento farmacológico
Edema/patologia
Feminino
Indometacina/farmacologia
Inflamação/tratamento farmacológico
Inflamação/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
Fenóis/isolamento & purificação
Fenóis/farmacologia
Folhas de Planta
Ratos
Ratos Wistar
Rutina/isolamento & purificação
Rutina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 5G06TVY3R7 (Rutin); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1321022


  6 / 2406 MEDLINE  
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[PMID]:29339217
[Au] Autor:Dobrzynska I; Gegotek A; Gajko E; Skrzydlewska E; Figaszewski ZA
[Ad] Endereço:Institute of Chemistry, University in Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland. Electronic address: izadob@uwb.edu.pl.
[Ti] Título:Effects of rutin on the physicochemical properties of skin fibroblasts membrane disruption following UV radiation.
[So] Source:Chem Biol Interact;282:29-35, 2018 Feb 25.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Human skin provides the body's first line of defense against physical and environmental assaults. This study sought to determine how rutin affects the membrane electrical properties, sialic acid content, and lipid peroxidation levels of fibroblast membranes after disruption by ultraviolet (UV) radiation. Changes in cell function may affect the basal electrical surface properties of cell membranes, and changes can be detected by electrokinetic measurements. The charge density of the fibroblast membrane surface was measured as a function of pH. A four-component equilibrium model was used to describe the interaction between ions in solution and ions on the membrane surface. Agreement was found between experimental and theoretical charge variation curves of fibroblast cells between pH 2.5 and 8. Sialic acid content was determined by Svennerholm's resorcinol method, and lipid peroxidation was estimated by measuring the malondialdehyde level. Compared to untreated cells, ultraviolet A (UVA)- or ultraviolet B (UVB)-treated skin cell membranes exhibited higher concentrations of acidic functional groups and higher average association constants with hydroxyl ions, but lower average association constants with hydrogen ions. Moreover, our results showed that UVA and UVB radiation is associated with increased levels of sialic acid and lipid peroxidation products in fibroblasts. Rutin protected cells from some deleterious UV-associated membrane changes, including changes in electrical properties, oxidative state, and biological functions.
[Mh] Termos MeSH primário: Membrana Celular/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Rutina/farmacologia
Pele/efeitos dos fármacos
Raios Ultravioleta/efeitos adversos
[Mh] Termos MeSH secundário: Linhagem Celular
Membrana Celular/metabolismo
Fibroblastos/metabolismo
Seres Humanos
Hidrogênio/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/metabolismo
Oxirredução/efeitos dos fármacos
Pele/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
4Y8F71G49Q (Malondialdehyde); 5G06TVY3R7 (Rutin); 7YNJ3PO35Z (Hydrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


  7 / 2406 MEDLINE  
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[PMID]:29261741
[Au] Autor:Gao J; Wang T; Liu M; Liu J; Zhang Z
[Ad] Endereço:The Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing, China.
[Ti] Título:Transcriptome analysis of filling stage seeds among three buckwheat species with emphasis on rutin accumulation.
[So] Source:PLoS One;12(12):e0189672, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Buckwheat is an important minor crop with pharmaceutical functions due to rutin enrichment in the seed. Seeds of common buckwheat cultivars (Fagopyrum esculentum, Fes) usually have much lower rutin content than tartary buckwheat (F. tartaricum, Ft). We previously found a wild species of common buckwheat (F. esculentum ssp. ancestrale, Fea), with seeds that are high in rutin, similar to Ft. In the present study, we investigated the mechanism by which rutin production varies among different buckwheat cultivars, Fea, a Ft variety (Xide) and a Fes variety (No.2 Pingqiao) using RNA sequencing of filling stage seeds. Sequencing data generated approximately 43.78-Gb of clean bases, all these data were pooled together and assembled 180,568 transcripts, and 109,952 unigenes. We established seed gene expression profiles of each buckwheat sample and assessed genes involved in flavonoid biosynthesis, storage proteins production, CYP450 family, starch and sucrose metabolism, and transcription factors. Differentially expressed genes between Fea and Fes were further analyzed due to their close relationship than with Ft. Expression levels of flavonoid biosynthesis gene FLS1 (Flavonol synthase 1) were similar in Fea and Ft, and much higher than in Fes, which was validated by qRT-PCR. This suggests that FLS1 transcript levels may be associated with rutin accumulation in filling stage seeds of buckwheat species. Further, we explored transcription factors by iTAK, and multiple gene families were identified as being involved in the coordinate regulation of metabolism and development. Our extensive transcriptomic data sets provide a complete description of metabolically related genes that are differentially expressed in filling stage buckwheat seeds and suggests that FLS1 is a key controller of rutin synthesis in buckwheat species. FLS1 can effectively convert dihydroflavonoids into flavonol products. These findings provide a basis for further studies of flavonoid biosynthesis in buckwheat breeding to help accelerate flavonoid metabolic engineering that would increase rutin content in cultivars of common buckwheat.
[Mh] Termos MeSH primário: Fagopyrum/embriologia
Fagopyrum/genética
Genes de Plantas
Rutina/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Fagopyrum/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Sementes/metabolismo
Análise de Sequência de RNA
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
5G06TVY3R7 (Rutin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189672


  8 / 2406 MEDLINE  
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[PMID]:28467992
[Au] Autor:Sun CL; Wei J; Bi LQ
[Ad] Endereço:Department of Rheumatology and Immunology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, and Department of Rheumatology and Immunology, China-Japan Union Hospital of Jilin University, Changchun, China.
[Ti] Título:Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB.
[So] Source:Pharmacology;100(1-2):40-49, 2017.
[Is] ISSN:1423-0313
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The present study was intended to elucidate the effect of rutin, a flavonoid, on arthritis in complete Freund's adjuvant-induced arthritic rats. The present study showed that more pronounced effect has been observed in the case of 15 mg/kg dose of rutin, with significant reduction in paw diameter together with positive modulation of hematological parameters as compared to 2 other tested doses. A significant upsurge in the level of superoxide dismutase, glutathione peroxidase and glutathione were observed together with decrease in the level of malondialdehyde after treatment with rutin in a dose-dependent manner. Furthermore, the effect of rutin on the tumor necrosis factor-α and interleukin-1ß in arthritic rats showed does-dependent lowering of these cytokines with maximum benefit at 15 mg/kg dose and the level of both NF-κB p65 and NF-κBp65 (Ser536) has been significantly reduced in the presence of rutin. Histopathological examination showed that the inflammatory cells infiltration, synovial hyperplasia, pannus formation and cartilage and bone erosion had considerably improved on administration of rutin. In conclusion, our paper strongly demonstrated the protective effect of rutin against the rheumatoid arthritis involved via suppression of NF-κB p65 protein expression.
[Mh] Termos MeSH primário: Artrite Experimental/tratamento farmacológico
Artrite Reumatoide/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Rutina/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacologia
Artrite Experimental/patologia
Artrite Reumatoide/patologia
Citocinas/metabolismo
Relação Dose-Resposta a Droga
Adjuvante de Freund
Interleucina-1beta/metabolismo
Malondialdeído/metabolismo
Ratos
Ratos Wistar
Rutina/administração & dosagem
Fator de Transcrição RelA/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Interleukin-1beta); 0 (Transcription Factor RelA); 0 (Tumor Necrosis Factor-alpha); 4Y8F71G49Q (Malondialdehyde); 5G06TVY3R7 (Rutin); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180104
[Lr] Data última revisão:
180104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1159/000451027


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[PMID]:28962559
[Au] Autor:Almutairi MM; Alanazi WA; Alshammari MA; Alotaibi MR; Alhoshani AR; Al-Rejaie SS; Hafez MM; Al-Shabanah OA
[Ad] Endereço:Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia.
[Ti] Título:Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model.
[So] Source:BMC Complement Altern Med;17(1):472, 2017 Sep 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cisplatin is widely used chemotherapeutic agent for cancer treatment with limited uses due to its neurotoxic side effect. The aim of this study was to determine the potential preventive effects of rutin on the brain of cisplatin- neurotoxic rat model. METHODS: Forty rats were divided into four groups. Group-1 (control group) was intra-peritoneal (IP) injected with 2.5 ml/kg saline. Group-2 (rutin group) was orally administrated 30 mg/kg rutin dissolved in water for 14 days. Group-3 (cisplatin group) was IP received 5 mg/kg cisplatin single dose. Group-4 (rutin and cisplatin group) was orally administrated 30 mg/kg rutin dissolved in water for 14 days with a single dose of 5 mg/kg cisplatin IP on day ten. Brain tissues from frontal cortex was used to extract RNA, the gene expression levels of paraoxonase-1 (PON-1), PON-2, PON-3, peroxisome proliferator-activated receptor delta (PPAR-δ), and glutathione peroxidase (GPx) was investigated by Real-time PCR. RESULTS: Cisplatin significantly decreased the expression levels of PON-1, PON-3, PPAR-δ and GPX whereas significantly increased PON-2 expression levels. Co-administration of Rutin prevented the cisplatin-induced toxicity by restoring the alteration in the studied genes to normal values as in the control group. CONCLUSION: This study showed that Rutin has neuroprotective effect and reduces cisplatin- neurotoxicity with possible mechanism via the antioxidant pathway.
[Mh] Termos MeSH primário: Encéfalo/efeitos dos fármacos
Cisplatino/efeitos adversos
Fármacos Neuroprotetores/farmacologia
Rutina/farmacologia
[Mh] Termos MeSH secundário: Animais
Peso Corporal/efeitos dos fármacos
Encéfalo/enzimologia
Encéfalo/metabolismo
Química Encefálica/efeitos dos fármacos
Glutationa/metabolismo
Glutationa Peroxidase/análise
Glutationa Peroxidase/genética
Glutationa Peroxidase/metabolismo
Masculino
Estresse Oxidativo/efeitos dos fármacos
PPAR delta/análise
PPAR delta/genética
PPAR delta/metabolismo
Ratos
Ratos Wistar
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (PPAR delta); 0 (Thiobarbituric Acid Reactive Substances); 5G06TVY3R7 (Rutin); EC 1.11.1.9 (Glutathione Peroxidase); GAN16C9B8O (Glutathione); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171001
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1976-9


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[PMID]:28715245
[Au] Autor:Shi J; Li W; Gao Y; Wang B; Li Y; Song Z
[Ad] Endereço:a Yunnan Academy of Tobacco Agricultural Sciences , Kunming , China.
[Ti] Título:Enhanced rutin accumulation in tobacco leaves by overexpressing the NtFLS2 gene.
[So] Source:Biosci Biotechnol Biochem;81(9):1721-1725, 2017 Sep.
[Is] ISSN:1347-6947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Rutin, one of the metabolites of the flavonoid pathway, shows great potential in industrial applications as a key component in pharmaceutical medicines and biological pesticides. Although the genetic manipulation of transcription factors (TFs) could increase rutin levels in plants, the accompanying accumulation of structurally similar chemicals complicates industrial rutin extraction. In this study, we demonstrated remarkably elevated rutin content (3.5-4.4-fold relative to controls) in transgenic tobacco plants by overexpressing NtFLS2. The levels of other intermediates in the branch pathway did not change much except for a moderate increase of kaempferol-3-O-rutinoside. Furthermore, the transcript levels of pathway genes in transgenic lines were comparable with controls, indicating genetic engineering did not significantly alter the branch pathway. Additionally, the transgenic tobacco plants appeared normal except for a flower color change from light red to white suggesting that it could be a valuable material for industrial extraction of rutin.
[Mh] Termos MeSH primário: Oxirredutases/genética
Folhas de Planta/metabolismo
Proteínas de Plantas/genética
Rutina/metabolismo
Tabaco/genética
Tabaco/metabolismo
[Mh] Termos MeSH secundário: Flavonoides/biossíntese
Flavonoides/metabolismo
Expressão Gênica
Filogenia
Plantas Geneticamente Modificadas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Proteins); 5G06TVY3R7 (Rutin); EC 1.- (Oxidoreductases); EC 1.3.- (flavonol synthase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170718
[St] Status:MEDLINE
[do] DOI:10.1080/09168451.2017.1353401



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