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  1 / 2705 MEDLINE  
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[PMID]:29331860
[Au] Autor:Sáez V; Gayoso C; Riquelme S; Pérez J; Vergara C; Mardones C; von Baer D
[Ad] Endereço:Facultad de Farmacia, Departamento de Análisis Instrumental, Universidad de Concepción, Chile.
[Ti] Título:C18 core-shell column with in-series absorbance and fluorescence detection for simultaneous monitoring of changes in stilbenoid and proanthocyanidin concentrations during grape cane storage.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1074-1075:70-78, 2018 Feb 01.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Grape canes, the residues from the annual pruning of vines, contain high levels of inducible (E)-resveratrol and also oligomeric stilbenoids and proanthocyanidins. These two families of phenolic compounds are bioactive, but to quantify them in a single chromatographic run using only ultraviolet detection is a difficult task. To overcome this limitation, a chromatographic method was developed using a core shell column for separation, an ultraviolet-visible diode array detector (DAD) and a fluorescence (FL) detector connected in series for quantification, with an electrospray ionization interface (ESI) and a triple quadrupole mass spectrometric detector (MS/MS) added for identification of the analytes. The proanthocyanidins (+)-catechin, (-)-epicatechin, procyanidins B1, B2, and C1, an unknown dimer and trimer, two prodelphinidin dimers, and monogallate procyanidin dimers were detected in the tested grape cane samples. The stilbenoids detected were (E)-resveratrol, (E)-piceatannol, (E)-piceid, (E)-ε-viniferin, vitisin B, a glycosylated monomer, three oxidized dimers, an unknown dimer and a tetramer, pallidol, hopeaphenol, (E)-δ-viniferin, and (E)-ω-viniferin. However, this method required 60min for each analysis. A faster and more efficient method for quantitative analysis was developed based on HPLC-DAD-FL, reducing the time required to 24min for the simultaneous quantification of proanthocyanidins and stilbenoids in Cabernet Sauvignon, Pinot Noir, and Tintorera grape canes stored at controlled temperatures and relativity humidities for 134days after pruning. To the best of our knowledge, this is the first time a prodelphinidin dimer has been quantified in grape canes. The incorporation of fluorescence detection in series with DAD not only allowed the quantification of proanthocyanidins, it also improved the detectability of some minor stilbenoids present in the canes, such as (E)-piceid. The (E)-resveratrol and (E)-piceatannol levels increased significantly during cane storage, while those of (E)-ε-viniferin and ampelopsin A did not show significant increases. The relative humidity had a determining effect on the levels of (E)-resveratrol and (E)-piceatannol in the canes of all varieties studied; their concentrations were higher at a relative humidity of 60% than at 70%. This is the first time that the proanthocyanidin profiles of canes stored after pruning were monitored under controlled conditions of temperature, time and relative humidity. The concentration of (-)-epicatechin decreased during storage under both relative humidities. Furthermore, the levels of proanthocyanidin B1 and the prodelphinidin dimer also decreased to a certain extent.
[Mh] Termos MeSH primário: Proantocianidinas/análise
Espectrometria de Fluorescência/métodos
Estilbenos/análise
Vitis/química
[Mh] Termos MeSH secundário: Frutas/química
Limite de Detecção
Modelos Lineares
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proanthocyanidins); 0 (Stilbenes)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


  2 / 2705 MEDLINE  
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[PMID]:29205955
[Au] Autor:Li B; Weng Q; Liu Z; Shen M; Zhang J; Wu W; Liu H
[Ad] Endereço:College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, People's Republic of China.
[Ti] Título:Selection of antioxidants against ovarian oxidative stress in mouse model.
[So] Source:J Biochem Mol Toxicol;31(12), 2017 Dec.
[Is] ISSN:1099-0461
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oxidative stress (OS) plays an important role in the process of ovarian granulosa cell apoptosis and follicular atresia. The aim of this study was to select antioxidant against OS in ovary tissue. Firstly, we chose the six antioxidants and analyzed the reactive oxygen species (ROS) level in the ovary tissue. The results showed that proanthocyanidins, gallic acid, curcumin, and carotene decrease the ROS level compared with control group. We further demonstrated that both proanthocyanidins and gallic acid increase the antioxidant enzymes activity. Moreover, change in the ROS level was not observed in proanthocyanidins and gallic acid group of brain, liver, spleen, and kidney tissues. Finally, we found that proanthocyanidins and gallic acid inhibit pro-apoptotic genes expression in granulosa cells. Taken together, proanthocyanidins and gallic acid may be the most acceptable and optimal antioxidants specifically against ovarian OS and also may be involved in the inhibition of granulosa cells apoptosis in mouse ovary.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Ácido Gálico/farmacologia
Ovário/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Proantocianidinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Apoptose
Proteínas Reguladoras de Apoptose/genética
Proteínas Reguladoras de Apoptose/metabolismo
Avaliação Pré-Clínica de Medicamentos
Feminino
Expressão Gênica/efeitos dos fármacos
Camundongos Endogâmicos ICR
Ovário/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Apoptosis Regulatory Proteins); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 18206-61-6 (proanthocyanidin); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.1002/jbt.21997


  3 / 2705 MEDLINE  
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[PMID]:29321009
[Au] Autor:Ben Lagha A; LeBel G; Grenier D
[Ad] Endereço:Oral Ecology Research Group (GREB), Faculty of Dentistry, Université Laval, 2420 Rue de la Terrasse, Quebec City, QC, G1V 0A6, Canada.
[Ti] Título:Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response.
[So] Source:BMC Complement Altern Med;18(1):10, 2018 Jan 10.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The highbush blueberry (Vaccinium corymbosum) has a beneficial effect on several aspects of human health. The present study investigated the effects of highbush blueberry proanthocyanidins (PACs) on the virulence properties of Aggregatibacter actinomycetemcomitans and macrophage-associated inflammatory responses. METHODS: PACs were isolated from frozen highbush blueberries using solid-phase chromatography. A microplate dilution assay was performed to determine the effect of highbush blueberry PACs on A. actinomycetemcomitans growth as well as biofilm formation stained with crystal violet. Tight junction integrity of oral keratinocytes was assessed by measuring the transepithelial electrical resistance (TER), while macrophage viability was determined with a colorimetric MTT assay. Pro-inflammatory cytokine and MMP secretion by A. actinomycetemcomitans-stimulated macrophages was quantified by ELISA. The U937-3xκB-LUC monocyte cell line transfected with a luciferase reporter gene was used to monitor NF-κB activation. RESULTS: Highbush blueberry PACs reduced the growth of A. actinomycetemcomitans and prevented biofilm formation at sub-inhibitory concentrations. The treatment of pre-formed biofilms with the PACs resulted in a loss of bacterial viability. The antibacterial activity of the PACs appeared to involve damage to the bacterial cell membrane. The PACs protected the oral keratinocytes barrier integrity from damage caused by A. actinomycetemcomitans. The PACs also protected macrophages from the deleterious effect of leukotoxin Ltx-A and dose-dependently inhibited the secretion of pro-inflammatory cytokines (IL-1ß, IL-6, CXCL8, TNF-α), matrix metalloproteinases (MMP-3, MMP-9), and sTREM-1 by A. actinomycetemcomitans-treated macrophages. The PACs also inhibited the activation of the NF-κB signaling pathway. CONCLUSION: The antibacterial and anti-inflammatory properties of highbush blueberry PACs as well as their ability to protect the oral keratinocyte barrier and neutralize leukotoxin activity suggest that they may be promising candidates as novel therapeutic agents.
[Mh] Termos MeSH primário: Aggregatibacter actinomycetemcomitans
Mirtilos Azuis (Planta)/química
Interações Hospedeiro-Patógeno
Extratos Vegetais/farmacologia
Proantocianidinas/farmacologia
[Mh] Termos MeSH secundário: Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Aggregatibacter actinomycetemcomitans/imunologia
Citocinas/metabolismo
Interações Hospedeiro-Patógeno/efeitos dos fármacos
Interações Hospedeiro-Patógeno/imunologia
Seres Humanos
Queratinócitos/citologia
Queratinócitos/efeitos dos fármacos
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
NF-kappa B/metabolismo
Periodontite
Extratos Vegetais/química
Proantocianidinas/química
Junções Íntimas
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Proanthocyanidins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2072-x


  4 / 2705 MEDLINE  
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[PMID]:29313327
[Au] Autor:Chai WM; Huang Q; Lin MZ; Ou-Yang C; Huang WY; Wang YX; Xu KL; Feng HL
[Ad] Endereço:College of Life Science and Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Jiangxi Normal University , Nanchang, Jiangxi 330022, People's Republic of China.
[Ti] Título:Condensed Tannins from Longan Bark as Inhibitor of Tyrosinase: Structure, Activity, and Mechanism.
[So] Source:J Agric Food Chem;66(4):908-917, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, the content, structure, antityrosinase activity, and mechanism of longan bark condensed tannins were evaluated. The findings obtained from mass spectrometry demonstrated that longan bark condensed tannins were mixtures of procyanidins, propelargonidins, prodelphinidins, and their acyl derivatives (galloyl and p-hydroxybenzoate). The enzyme analysis indicated that these mixtures were efficient, reversible, and mixed (competitive is dominant) inhibitor of tyrosinase. What's more, the mixtures showed good inhibitions on proliferation, intracellular enzyme activity and melanogenesis of mouse melanoma cells (B ). From molecular docking, the results showed the interactions between inhibitors and tyrosinase were driven by hydrogen bond, electrostatic, and hydrophobic interactions. In addition, high levels of total phenolic and extractable condensed tannins suggested that longan bark might be a good source of tyrosinase inhibitor. This study would offer theoretical basis for the development of longan bark condensed tannins as novel food preservatives and medicines of skin diseases.
[Mh] Termos MeSH primário: Inibidores Enzimáticos/farmacologia
Monofenol Mono-Oxigenase/antagonistas & inibidores
Casca de Planta/química
Sapindaceae/química
Taninos/química
Taninos/farmacologia
[Mh] Termos MeSH secundário: Animais
Antocianinas/farmacologia
Biflavonoides/farmacologia
Catequina/farmacologia
Proliferação Celular/efeitos dos fármacos
Ligações de Hidrogênio
Interações Hidrofóbicas e Hidrofílicas
Espectrometria de Massas
Melaninas/análise
Melaninas/antagonistas & inibidores
Melaninas/biossíntese
Melanoma Experimental
Camundongos
Modelos Moleculares
Simulação de Acoplamento Molecular
Oxirredutases
Parabenos/farmacologia
Proantocianidinas/farmacologia
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Eletricidade Estática
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Biflavonoids); 0 (Enzyme Inhibitors); 0 (Melanins); 0 (Parabens); 0 (Proanthocyanidins); 0 (Tannins); 4852-22-6 (procyanidin); 8R1V1STN48 (Catechin); EC 1.- (Oxidoreductases); EC 1.14.18.- (monophenolase); EC 1.14.18.1 (Monophenol Monooxygenase); EM6MD4AEHE (delphinidin); JG8Z55Y12H (4-hydroxybenzoic acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b05481


  5 / 2705 MEDLINE  
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[PMID]:29258053
[Au] Autor:Zhang T; Sharma A; Li Y; Zhou Y; Ding X
[Ad] Endereço:School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China.
[Ti] Título:Orthogonal Array composite design to study and optimize antioxidant combinations in the prevention of UVB-induced HSF damage.
[So] Source:J Photochem Photobiol B;178:568-576, 2018 Jan.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Excessive exposure to ultraviolet (UV) B radiation may lead to skin damage, photosensitivity, or even tumorigenesis via induction of oxidative stress. Naturally derived antioxidants could play significant roles in cancer therapy due to their multi-targeted actions and lack of substantial toxicity. Drug combinations target at diverse pathway of cells and make cells export meticulous biological outcomes through the multifaceted signaling network. The UVB protective effects of combinations of naturally derived antioxidants- curcumin, resveratrol, proanthocyanidins, baicalein, and beta-nicotinamide adenine dinucleotide (NADH) were investigated. An oxidative cell damage model was established to study the ultraviolet irradiation system. An orthogonal array composite design (OACD) was employed in the optimization of antioxidants combinations. Combination of resveratrol (0.1µM) and baicalein in medium concentration (0.2µM), with NADH in high concentration (0.8µM) was found to be the most efficacious combination among all the 30 runs performed using OACD. The findings suggested that UVB exposure-inflicted cell apoptosis can be significantly reduced by naturally-derived antioxidant combinations. These results provide an insight into the discovery of synergistic antioxidant combinations in skin cancer, using orthogonal array composite design (OACD). The results also have practical implications in the understanding of drug mechanisms in skin cancer, which can assist clinical practice by recommending better drug combinations.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Raios Ultravioleta
[Mh] Termos MeSH secundário: Antioxidantes/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Curcumina/química
Curcumina/farmacologia
Fragmentação do DNA/efeitos dos fármacos
Fragmentação do DNA/efeitos da radiação
Fibroblastos/citologia
Fibroblastos/efeitos dos fármacos
Fibroblastos/efeitos da radiação
Flavanonas/química
Flavanonas/farmacologia
Seres Humanos
Modelos Lineares
Estresse Oxidativo/efeitos da radiação
Proantocianidinas/química
Proantocianidinas/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Pele/citologia
Estilbenos/química
Estilbenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavanones); 0 (Proanthocyanidins); 0 (Reactive Oxygen Species); 0 (Stilbenes); 49QAH60606 (baicalein); IT942ZTH98 (Curcumin); Q369O8926L (resveratrol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


  6 / 2705 MEDLINE  
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[PMID]:28449181
[Au] Autor:Corradi E; Schmidt N; Räber N; De Mieri M; Hamburger M; Butterweck V; Potterat O
[Ad] Endereço:Division of Pharmaceutical Biology, University of Basel, Switzerland.
[Ti] Título:Metabolite Profile and Antiproliferative Effects in HaCaT Cells of a Salix reticulata Extract.
[So] Source:Planta Med;83(14-15):1149-1158, 2017 Oct.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phenolic constituents of (Salicaceae) and antiproliferative activity of an extract and individual compounds were investigated in immortalized human non-tumorigenic keratinocytes (HaCaT). A MeOH extract from aerial parts afforded several flavonoids, including luteolin and apigenin glycosides ( - and ) and catechin ( ), two procyanidin fractions, and the phenolic glucosides picein ( ), triandrin ( ), and salicortin ( ). In an adenosine triphosphate assay, the MeOH extract reduced cell viability by approximately 60 % at a concentration of 100 µg/mL. Cell proliferation was assessed with a BrdU incorporation ELISA assay. The extract inhibited proliferation of HaCaT cells in a concentration-dependent manner, with approximately 50 % inhibition at 100 µg/mL. In time-lapse assays, the extract showed distinct inhibitory effects on cell migration at concentrations of 12.5, 25, and 50 µg/mL. The activity of selected constituents was also determined. Luteolin-7-O- -glucuronide ( ) significantly inhibited cell proliferation at concentrations of 10 and 50 µM. In contrast, luteolin-7-O- -glucopyranoside ( ) and a procyanidin fraction (P1) had only weak effects, while picein ( ) and salicortin ( ) did not affect cell proliferation. Luteolin-7-O- -glucuronide (10 µM) and, to a lesser extent, the procyanidin fraction (10 µg/mL) also inhibited cell migration.
[Mh] Termos MeSH primário: Glicosídeos/farmacologia
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Salix/química
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Flavonas/metabolismo
Glucuronídeos/metabolismo
Glicosídeos/isolamento & purificação
Seres Humanos
Queratinócitos/efeitos dos fármacos
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Proantocianidinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavones); 0 (Glucuronides); 0 (Glycosides); 0 (Phenols); 0 (Plant Extracts); 0 (Proanthocyanidins); S2V45N7G3B (flavone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180201
[Lr] Data última revisão:
180201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1055/s-0043-109098


  7 / 2705 MEDLINE  
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[PMID]:28921512
[Au] Autor:Van Sebille YZA; Gibson RJ; Wardill HR; Ball IA; Keefe DMK; Bowen JM
[Ad] Endereço:Discipline of Physiology, Adelaide Medical School, University of Adelaide, Australia.
[Ti] Título:Dacomitinib-induced diarrhea: Targeting chloride secretion with crofelemer.
[So] Source:Int J Cancer;142(2):369-380, 2018 Jan 15.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dacomitinib, an irreversible small-molecule pan-ErbB TKI, has a high incidence of diarrhea, which has been suggested to be due to chloride secretory mechanisms. Based on this hypothesis, crofelemer, an antisecretory agent may be an effective intervention. T84 monolayers were treated with 1 µM dacomitinib and 10 µM crofelemer, and mounted into Ussing chambers for electrogenic ion analysis. Crofelemer attenuated increases in chloride secretion in cells treated with dacomitinib. Albino Wistar rats (n = 48) were treated with 7.5 mg/kg dacomitinib and/or 25 mg/kg crofelemer via oral gavage for 21 days. Crofelemer significantly worsened dacomitinib-induced diarrhea (p = 0.0003), and did not attenuate weight loss (p < 0.0001). Sections of the ileum and colon were mounted into Ussing chambers, and secretory processes analyzed. This indicated that crofelemer lost its anti-secretory action in the presence of dacomitinib in this model. Mass spectrometry revealed that crofelemer did not change serum concentration of dacomitinib. Serum FITC dextran levels indicated that crofelemer was unable to attenuate dacomitinib-induced barrier dysfunction. Tight junction proteins were visualized with immunofluorescence. Qualitative analysis showed dacomitinib induced proteolysis of ZO-1 and occludin, and internalization of claudin-1, which was not attenuated by crofelemer. Detailed histopathological analysis showed that crofelemer was unable to attenuate dacomitinib-induced ileal damage. Crofelemer worsened dacomitinib-induced diarrhea, suggesting that antisecretory drug therapy may be ineffective in this setting.
[Mh] Termos MeSH primário: Cloretos/metabolismo
Diarreia/tratamento farmacológico
Proantocianidinas/farmacologia
Quinazolinonas/toxicidade
[Mh] Termos MeSH secundário: Animais
Permeabilidade da Membrana Celular/efeitos dos fármacos
Neoplasias Colorretais/tratamento farmacológico
Neoplasias Colorretais/metabolismo
Neoplasias Colorretais/patologia
Diarreia/induzido quimicamente
Diarreia/metabolismo
Eletrofisiologia
Trato Gastrointestinal/efeitos dos fármacos
Trato Gastrointestinal/metabolismo
Trato Gastrointestinal/patologia
Seres Humanos
Masculino
Ratos
Ratos Wistar
Células Tumorais Cultivadas
Perda de Peso/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (PF 00299804); 0 (Proanthocyanidins); 0 (Quinazolinones); PY79D6C8RX (crofelemer)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171214
[Lr] Data última revisão:
171214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.31048


  8 / 2705 MEDLINE  
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[PMID]:28873629
[Au] Autor:Shao Y; Hu Z; Yu Y; Mou R; Zhu Z; Beta T
[Ad] Endereço:China National Rice Research Institute, Hangzhou 310006, China.
[Ti] Título:Phenolic acids, anthocyanins, proanthocyanidins, antioxidant activity, minerals and their correlations in non-pigmented, red, and black rice.
[So] Source:Food Chem;239:733-741, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Soluble-free, soluble-conjugated, insoluble-bound phenolics and antioxidant activity, flavonoid (TFC), proanthocyanidins (TPAC), anthocyanins and minerals of fifteen whole rice grains with different colors were investigated. Soluble-free protocatechuic and vanillic acids were only quantified in black rice, which had the most quantities. Non-pigmented rice had no detectable conjugated protocatechuic and 2,5-dihydroxybenzoic acids both of which were found in black and red rice, respectively. The main bound phenolic acids were ferulic and p-coumaric, as well as 2,5-dihydroxybenzoic in red rice and protocatechuic and vanillic acids in black rice. Soluble-conjugated phenolics, TFC, and anthocyanins were negatively correlated with L , b , C and H° values. TPAC was positively correlated with a (P<0.01). Protocatechuic, vanillic, syringic and ferulic acids were associated with TPC and antioxidant activity in the soluble-conjugated fraction while protocatechuic and ferulic acid were correlated with those in the insoluble-bound fraction. Principal component analysis divided samples into non-pigmented, red and black rice groups.
[Mh] Termos MeSH primário: Oryza
[Mh] Termos MeSH secundário: Antocianinas
Antioxidantes
Hidroxibenzoatos
Minerais
Fenóis
Extratos Vegetais
Proantocianidinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthocyanins); 0 (Antioxidants); 0 (Hydroxybenzoates); 0 (Minerals); 0 (Phenols); 0 (Plant Extracts); 0 (Proanthocyanidins); 29656-58-4 (phenolic acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  9 / 2705 MEDLINE  
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[PMID]:28873557
[Au] Autor:Machado KN; Freitas AA; Cunha LH; Faraco AAG; Pádua RM; Braga FC; Vianna-Soares CD; Castilho RO
[Ad] Endereço:Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais (UFMG), Av. Pres. Antônio Carlos 6627, Belo Horizonte, Minas Gerais, Brazil. Electronic address: kamilla.ufop@gmail.com.
[Ti] Título:A rapid simultaneous determination of methylxanthines and proanthocyanidins in Brazilian guaraná (Paullinia cupana Kunth.).
[So] Source:Food Chem;239:180-188, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Paullinia cupana is a plant native to Brazil that is widely used in traditional medicine as a physical and mental stimulant. It is also used worldwide to produce soft drinks. A method for the simultaneous quantitation of seven markers in guaraná by HPLC-PDA was developed, and extraction methods for the determination of methylxanthines and tannins were investigated. Quantified substances were theobromine, theophylline, caffeine, catechin, epicatechin, procyanidins A2 and B2. Results confirmed the satisfactory selectivity and linearity (r ≥0.99) within the mass ranges. Repeatability (RSD≤2.80%), intermediate precision (RSD≤4.47%), accuracy (recoveries from 90.59%-104.67%), and robustness were demonstrated. Extract 1 presented the contents: 0.0177% (±1.02%) for theobromine, 0.0131% (±1.14%) for theophylline, 2.9429% (±1.27%) for caffeine, 0.4563% (±1.02%) for catechin, 0.5515% (±1.05%) for epicatechin, 0.0607% (±2.80%) for A2 and 0.1035% (±1.39%) for B2. The method for simultaneous quantitation of seven chemical markers in guaraná proved to be reliable using a simple and convenient HPLC setup.
[Mh] Termos MeSH primário: Paullinia
[Mh] Termos MeSH secundário: Brasil
Cafeína
Extratos Vegetais
Proantocianidinas
Xantinas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Proanthocyanidins); 0 (Xanthines); 28109-92-4 (methylxanthine); 3G6A5W338E (Caffeine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


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[PMID]:28873531
[Au] Autor:Hayashi S; Nakano K; Yanase E
[Ad] Endereço:Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address: kmkm87720@gmail.com.
[Ti] Título:Investigation of color-deepening phenomenon in catechin-(4→8)-dimer as a proanthocyanidin model and structural determination of its derivatives by oxidation.
[So] Source:Food Chem;239:1126-1133, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:To elucidate the mechanism of the color-deepening phenomenon in aged red rice samples, a partial structure of proanthocyanidin, (+)-catechin-(4→8)-dimer (1), was synthesized as a model compound and subjected to chemical oxidation. HPLC analysis of oxidized 1 revealed new peaks which were isolated; among these, four compounds (2-5) having formed intramolecular bonds between the D and B rings were determined. These compounds and their derivatives in red rice extracts were identified by multiple reaction monitoring mass spectrometry. The UV-Vis spectra of 1-5 were recorded to clarify the correlation between the color-deepening effect and their chemical structures. Hence, the spectral absorption maxima between 300 and 500nm, corresponding to the oxidation products, increase. Therefore, the color-deepening phenomenon of red rice is thought to proceed via the formation of intramolecular bonds in proanthocyanidin by oxidation.
[Mh] Termos MeSH primário: Proantocianidinas/análise
[Mh] Termos MeSH secundário: Catequina
Cromatografia Líquida de Alta Pressão
Espectrometria de Massas
Oxirredução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proanthocyanidins); 8R1V1STN48 (Catechin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE



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