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[PMID]:29030270
[Au] Autor:Degen GH; Ali N; Gundert-Remy U
[Ad] Endereço:Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, D-44139 Dortmund, Germany. Electronic address: degen@ifado.de.
[Ti] Título:Preliminary data on citrinin kinetics in humans and their use to estimate citrinin exposure based on biomarkers.
[So] Source:Toxicol Lett;282:43-48, 2018 Jan 05.
[Is] ISSN:1879-3169
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Citrinin (CIT), a fungal metabolite causing nephrotoxicity, has a tolerable daily intake (TDI) value of 0.2µg/kg bw. Contamination of food with CIT is not sufficiently known to allow dietary exposure assessment. Urinary biomonitoring data are available from cohorts of several countries. However, kinetic information is lacking for CIT, hampering the use of urinary biomonitoring data to estimate the daily intake. We have investigated the kinetics of CIT after oral intake in two human volunteers on two occasions. Urinary excretion showed that ingested CIT undergoes conversion to dihydro-citrinone (DH-CIT) which is then excreted in the urine along with parent compound. The cumulative urinary excretion within 24h was between 32.9% and 70.8% (median 40.2%) of the sum of CIT and DH-CIT ('total CIT'). The median half-life in urine was 6.7h for CIT and 8.9h for DH-CIT. The median half-life in plasma accounted to 9.4h. The daily urinary excretion for 'total CIT' served to estimate a provisional daily CIT intake using published urine biomarker data in several cohorts. European cohorts had an exposure well below the TDI whereas in Bangladesh the exposure in one cohort exceeded the TDI.
[Mh] Termos MeSH primário: Citrinina/urina
Exposição Ambiental/análise
Micotoxinas/urina
[Mh] Termos MeSH secundário: Administração Oral
Biomarcadores/sangue
Biomarcadores/urina
Citrinina/sangue
Relação Dose-Resposta a Droga
Monitoramento Ambiental/métodos
Contaminação de Alimentos/análise
Meia-Vida
Voluntários Saudáveis
Seres Humanos
Taxa de Depuração Metabólica
Micotoxinas/sangue
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Mycotoxins); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171201
[Lr] Data última revisão:
171201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171015
[St] Status:MEDLINE


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[PMID]:28749978
[Au] Autor:Limay-Rios V; Miller JD; Schaafsma AW
[Ad] Endereço:Department of Plant Agriculture, University of Guelph, Ridgetown, Ontario, Canada.
[Ti] Título:Occurrence of Penicillium verrucosum, ochratoxin A, ochratoxin B and citrinin in on-farm stored winter wheat from the Canadian Great Lakes Region.
[So] Source:PLoS One;12(7):e0181239, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The occurrence of P. verrucosum and ochratoxin A (OTA) were surveyed for 3 and 4 years, respectively. A total of 250 samples was collected from an average of 30 farms during the 2011, 2012, 2013 and 2014 winter seasons. Most storage bins surveyed were typically 11 m high round bins made of corrugated, galvanized steel, with flat-bottoms and conical roofs. Samples of clumped grain contained the most P. verrucosum (p<0.05, n = 10) followed by samples taken from the first load (n = 24, mean = 147±87 CFU/g) and last load (n = 17, mean = 101±77 CFU/g). Five grain samples (2.2%) tested positive for OTA, citrinin and OTB at concentrations of 14.7±7.9, 4.9±1.9 and 1.2±0.7 ng/g, with only three samples exceeding 5 ng/g. Grain samples positive for OTA were related to moisture resulting from either condensation or migrating moist warm air in the bin or areas where precipitation including snow entered the bin. Bins containing grain and clumps contaminated with OTA were studied in detail. A number of statistically-significant risk factors for OTA contamination were identified. These included 1) grain clumps accumulated around or directly under manhole openings, 2) debris and residue of old grain or grain clumps collected from the bin walls or left on storage floor and augers and 3) grain clumps accumulated around side doors. Even when grain enters storage below the 14.5% threshold of moisture, condensation and moisture migration occurs in hotspots in modern corrugated steel storage bins. Hot spots of OTA contamination were most often in areas affected by moisture migration due to inadequate aeration and exposure to moisture from precipitation or condensation. Further, we found that the nature of the condensation affects the nature and distribution of small and isolated areas with high incidence of toxin contamination and/or P. verrucosum prevalence in the grain bins examined.
[Mh] Termos MeSH primário: Citrinina/metabolismo
Ocratoxinas/metabolismo
Penicillium/metabolismo
Estações do Ano
Triticum/microbiologia
[Mh] Termos MeSH secundário: Análise de Variância
Canadá
Cromatografia Líquida de Alta Pressão
Geografia
Great Lakes Region
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 3S697X6SNZ (Citrinin); ECJ5WS94N2 (ochratoxin B)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0181239


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[PMID]:28511111
[Au] Autor:Guijarro B; Larena I; Melgarejo P; De Cal A
[Ad] Endereço:Department of Plant Protection, Phytopathology Fungi Unit, National Institute for Agriculture and Food Research, INIA, Madrid, Spain.
[Ti] Título:Adaptive conditions and safety of the application of Penicillium frequentans as a biocontrol agent on stone fruit.
[So] Source:Int J Food Microbiol;254:25-35, 2017 Aug 02.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Penicillium frequentans (Pf909) reduces brown rot caused by Monilinia spp. in stone fruit. The registration of a microbial biocontrol agent in Europe requires information on the risks and safety of a biological product. This study focused on the impact of the physical environment on Pf909 survival and growth, Pf909 mycotoxin production on fruit surface, and the Pf909 resistance to commercial antifungal compounds used in animal and human medicine. The effect of temperature (4 to 37°C), water activity (0.999 to 0.900), pH (3 to 11), light intensity (0, 90 and 180lm) and photoperiod (0/24, 12/12, 16/8, 24/0; light/dark) on mycelial growth and sporulation of Pf909 were monitored for 10days in vitro on culture medium. Antifungal activity of antifungal compounds on mycelial growth of Pf909 was also measured by a quantitative micro spectrophotometric assay after 72h of incubation. The presence or absence of four non-volatile mycotoxins (patulin, penicillic acid, ochratoxin A and citrinin) on nectarine surfaces treated with Pf909 was determined by HPLC. Growth rate was significantly influenced by water activity, temperature and light exposure conditions. Pf909 showed maximum growth and sporulation at 22°C and 25°C, in wet conditions (0.999 water activity), with a pH5.6 to 9, and in darkness or a short light photoperiod. Our results showed all antifungal compounds used reduced significantly Pf909 mycelial growth at tested commercial doses. HPLC data analysis showed that 7days after biofungicide (Pf909) application there were no mycotoxin products on the surface of nectarine. Finally, no phylogenetic relationship has been shown among Pf909 and other species of Penicillium that produce mycotoxins. In conclusion, from an ecological point of view, Pf909 would establish and survive actively over a broad range of climatic conditions. The probability of risks to human and animal health is considered very low.
[Mh] Termos MeSH primário: Ascomicetos/crescimento & desenvolvimento
Agentes de Controle Biológico/efeitos adversos
Agentes de Controle Biológico/farmacologia
Inocuidade dos Alimentos/métodos
Frutas/microbiologia
Micotoxinas/isolamento & purificação
Penicillium/metabolismo
Prunus persica/microbiologia
[Mh] Termos MeSH secundário: Animais
Citrinina/isolamento & purificação
Europa (Continente)
Micélio/crescimento & desenvolvimento
Ocratoxinas/isolamento & purificação
Patulina/isolamento & purificação
Ácido Penicílico/isolamento & purificação
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Control Agents); 0 (Mycotoxins); 0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 3S697X6SNZ (Citrinin); 95X2BV4W8R (Patulin); ONL14K3AFD (Penicillic Acid)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170517
[St] Status:MEDLINE


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[PMID]:28480413
[Au] Autor:Culig B; Bevardi M; Bosnir J; Serdar S; Lasic D; Racz A; Galic A; Kuharic Z
[Ad] Endereço:Institute of public health "Dr. Andrija Stampar", Zagreb, Croatia.
[Ti] Título:PRESENCE OF CITRININ IN GRAINS AND ITS POSSIBLE HEALTH EFFECTS.
[So] Source:Afr J Tradit Complement Altern Med;14(3):22-30, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Citrinin is a mycotoxin produced by several species of the genera , and and it occurs mainly in stored grain. Citrinin is generally formed after harvest and occurs mainly in stored grains, it also occurs in other plant products. Often, the co-occurrence with other mycotoxins is observed, especially ochratoxin A, which is usually associated with endemic nephropathy. At the European Union level, systematic monitoring of Citrinin in grains began with the aim of determining its highest permissible amount in food. Thus, far the systematic monitoring of the above mentioned mycotoxin in Croatia is yet to begin. MATERIALS AND METHODS: The main goal of this study was to determine the presence of Citrinin in grains sampled in the area of Medimurje, Osijek-Baranja, Vukovar-Srijem and Brod-Posavina County. For the purpose of identification and quantification of citrinin, high performance liquid chromatograph (HPLC) with fluorescence was used (Calibration curve k > 0.999; Intra assay CV = 2.1%; Inter assay CV = 4.3%; LOQ < 1 µg/kg). RESULTS: From the area of Medimurje County, 10 samples of corn and 10 samples of wheat were analyzed. None of the samples contained Citrinin (<1 µg/kg). From the area of Osijek-Baranja and Vukovar-Srijem County, 15 samples from each County were analyzed. The mean value for the samples of Osijek-Baranja County was 19.63 µg/kg (median=15.8 µg/kg), while for Vukovar-Srijem County the mean value of citrinin was 14,6 µg/kg (median=1.23 µg/kg). From 5 analyzed samples from Brod-Posavina County, one of the samples contained citrinin in the amount of 23.8 µg/kg, while the registered amounts in the other samples were <1 µg/kg. CONCLUSION: The results show that grains from several Counties contain certain amounts of Citrinin possibly indicating a significant intake of citrinin in humans. It must be stated that grains and grain-based products are the basis of everyday diet of all age groups, especially small children, where higher intake of citrinin can occur. Consequently, we emphasize the need for systematic analysis of larger amount of samples, from both large grains and small grains, especially in the area of Brod-Posavina County, in order to obtain more realistic notion of citrinin contamination of grains and to asses the health risk in humans.
[Mh] Termos MeSH primário: Citrinina/análise
Grãos Comestíveis/química
Triticum/química
Zea mays/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Citrinina/efeitos adversos
Croácia
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i3.3


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[PMID]:28304351
[Au] Autor:Kalayu Yirga S; Ling S; Yang Y; Yuan J; Wang S
[Ad] Endereço:Fujian Key Laboratory of Pathogenic Fungi and Mycotoxins, Key Laboratory of Biopesticide and Chemical Biology of The Education Minister, School of Life Science, Fujian Agriculture And Forestry University, Fuzhou 35002, China. kalayu.yirga@yahoo.com.
[Ti] Título:The Preparation and Identification of a Monoclonal Antibody against Citrinin and the Development of Detection via Indirect Competitive ELISA.
[So] Source:Toxins (Basel);9(3), 2017 Mar 17.
[Is] ISSN:2072-6651
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Citrinin (CTN) is a hepato-nephrotoxic mycotoxin produced by fungi genera of , , and CTN contaminates grains, fruits, juices and vegetables, and causes various toxic effects to humans and animals. It has small molecular weight, which is non-immunogenic to animals. Thus, CTN was conjugated to bovine serum albumin (BSA) and ovalbumin (OVA), respectively, by amide bonds using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and -hydroxysuccinimide (NHS). Mice were immunized with CTN-BSA conjugates, and spleen cells of the immunized mice were fused with Sp2/0 myeloma cells to obtain 21H27 hybriodoma cell. Ascitic fluid of hybridoma cell was produced in mice abdomen, and purified using caprylic/ammonium sulfate precipitation method. The 21H27 anti-CTN mcAb was the IgG2a antibody subclass, and cross-reactivity results indicated that anti-CTN mcAb is specific to CTN with high affinity (2.0 × 108 L/mol). Indirect competitive ELISA (ic-ELISA) results showed that the linear range of detection was 0.01-5.96 ng/mL and the IC was 0.28 ng/mL with a lower detection limit (LOD) of 0.01 ng/mL. The average recovery was 93.8% ± 1.6% with a coefficient variation of 1.0%-4.3%. Hence, anti-CTN mcAb secreted by 21H27 hybridoma cell was successfully produced and can be used to detect CTN contaminated feed and foodstuffs.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/imunologia
Citrinina/imunologia
[Mh] Termos MeSH secundário: Animais
Citrinina/análise
Reações Cruzadas
Ensaio de Imunoadsorção Enzimática
Feminino
Farinha/análise
Contaminação de Alimentos/análise
Hibridomas
Imunoconjugados/imunologia
Camundongos Endogâmicos BALB C
Oryza/química
Soroalbumina Bovina/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Immunoconjugates); 27432CM55Q (Serum Albumin, Bovine); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE


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[PMID]:28276772
[Au] Autor:Liu F; Tian L; Chen G; Zhang LH; Liu B; Zhang W; Bai J; Hua H; Wang HF; Pei YH
[Ad] Endereço:a School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
[Ti] Título:Two new compounds from a marine-derived Penicillium griseofulvum T21-03.
[So] Source:J Asian Nat Prod Res;19(7):678-683, 2017 Jul.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A new phenolic acid compound, 46-dimethylcurvulinic acid (1) and a new citrinin monomer derivative penicitrinol P (2) were isolated from marine-derived Penicillium griseofulvum T21-03. The structures of 1 and 2 were elucidated on the basis of spectroscopic data.
[Mh] Termos MeSH primário: Citrinina/análogos & derivados
Citrinina/isolamento & purificação
Penicillium/química
Fenóis/isolamento & purificação
[Mh] Termos MeSH secundário: Citrinina/química
Biologia Marinha
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Fenóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (46-dimethylcurvulinic acid); 0 (Phenols); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1231671


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[PMID]:28257052
[Au] Autor:Zhang X; Liu W; Chen X; Cai J; Wang C; He W
[Ad] Endereço:College of Food Science & Engineering, Xuchang University, Xuchang 461000, China. xiaoweizhang1982@163.com.
[Ti] Título:Effects and Mechanism of Blue Light on Monascus in Liquid Fermentation.
[So] Source:Molecules;22(3), 2017 Mar 01.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The effect of light on and the underlying mechanism have received a great deal of interest for the industrial application of pigments. In this study, we have examined the effects of blue light on the culture morphology, mycelium growth, pigments, and citrinin yield of in liquid-state and oscillation fermentation, and explored the mechanism at a physiological level. It was found that blue light affected the colony morphology, the composition (chitin content), and permeability of the mycelium cell wall in static liquid culture, which indicates blue light benefits pigments secreting from aerial mycelium to culture medium. In liquid oscillation fermentation, the yields of pigments in fermentation broth (darkness 1741 U/g, blue light 2206 U/g) and mycelium (darkness 2442 U/g, blue light 1900 U/g) cultured under blue light and darkness are different. The total pigments produced per gram of mycelium under blue light was also higher (4663 U/g) than that in darkness (4352 U/g). However, the production of citrinin (88 µg/g) under blue light was evidently lower than that in darkness (150 µg/g). According to the degradation of citrinin caused by blue light and hydrogen peroxide, it can be concluded that blue light could degrade citrinin and inhibit the catalase activity of mycelium, subsequently suppressing the decomposition of hydrogen peroxide, which is the active species that degrades citrinin.
[Mh] Termos MeSH primário: Fermentação
Luz
Monascus/metabolismo
Monascus/efeitos da radiação
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Citrinina/biossíntese
Meios de Cultura
Glucosamina/química
Peróxido de Hidrogênio
Monascus/crescimento & desenvolvimento
Micélio/metabolismo
Fenótipo
Pigmentos Biológicos/biossíntese
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Culture Media); 0 (Pigments, Biological); 3S697X6SNZ (Citrinin); BBX060AN9V (Hydrogen Peroxide); N08U5BOQ1K (Glucosamine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170518
[Lr] Data última revisão:
170518
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170304
[St] Status:MEDLINE


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[PMID]:28187328
[Au] Autor:Decontardi S; Mauro A; Lima N; Battilani P
[Ad] Endereço:Department of Sustainable Crop Production, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy.
[Ti] Título:Survey of Penicillia associated with Italian grana cheese.
[So] Source:Int J Food Microbiol;246:25-31, 2017 Apr 04.
[Is] ISSN:1879-3460
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present work aimed to contribute information on the mycobiota associated with ripening grana cheese, with focus on the genus Penicillium as potential mycotoxin producers. Eighteen wheels of grana cheese, aged in different storehouses situated in Northern Italy, were sampled to isolate associated fungi. Penicillium spp. were commonly dominant; morphological observation and gene sequencing were applied to identify Penicillium at species level. P. crustosum and P. solitum were the dominant species. Citrinin and ochratoxin A mycotoxins were analysed and the latter was found in all grana cheese samples. These results confirmed that a polyphasic approach is mandatory for Penicillium identification at species level.
[Mh] Termos MeSH primário: Queijo/microbiologia
Microbiologia de Alimentos/métodos
Penicillium/isolamento & purificação
[Mh] Termos MeSH secundário: Citrinina/análise
Evolução Molecular
Itália
Micotoxinas/análise
Ocratoxinas/análise
Filogenia
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Mycotoxins); 0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE


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[PMID]:28130037
[Au] Autor:Oh SY; Cedergreen N; Yiannikouris A; Swamy HV; Karrow NA
[Ad] Endereço:Department of Animal Biosciences, Ontario Agriculture College (OAC), University of Guelph, Guelph, ON N1G 2W1, Canada. Electronic address: ohs@uoguelph.ca.
[Ti] Título:Assessing interactions of binary mixtures of Penicillium mycotoxins (PMs) by using a bovine macrophage cell line (BoMacs).
[So] Source:Toxicol Appl Pharmacol;318:33-40, 2017 Mar 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Penicillium mycotoxins (PMs) are toxic contaminants commonly found as mixtures in animal feed. Therefore, it is important to investigate potential joint toxicity of PM mixtures. In the present study, we assessed the joint effect of binary combinations of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA) and penicillic acid (PA) using independent action (IA) and concentration addition (CA) concepts. Previously published toxicity data (i.e. IC25; PM concentration that inhibited bovine macrophage (BoMacs) proliferation by 25%) were initially analyzed, and both concepts agreed that OTA+PA demonstrated synergism (p<0.05), while PAT+PA showed antagonism (p<0.05). When a follow-up dilution study was carried out using binary combinations of PMs at three different dilution levels (i.e. IC25, 0.5∗IC25, 0.25∗IC25), only the mixture of CIT+OTA at 0.5∗IC25 was determined to have synergism by both IA and CA concepts with Model Deviation Ratios (MDRs; the ratio of predicted versus observed effect concentrations) of 1.4 and 1.7, respectively. The joint effect of OTA+MPA, OTA+PA and CIT+PAT complied with the IA concept, while CIT+PA, PAT+MPA and PAT+PA were better predicted with the CA over the IA concept. The present study suggests to test both IA and CA concepts using multiple doses when assessing risk of mycotoxin mixtures if the mode of action is unknown. In addition, the study showed that the tested PMs could be predicted by IA or CA within an approximate two-fold certainty, raising the possibility for a joint risk assessment of mycotoxins in food and feed.
[Mh] Termos MeSH primário: Antibacterianos/metabolismo
Citrinina/metabolismo
Macrófagos/metabolismo
Micotoxinas/metabolismo
Ocratoxinas/metabolismo
Penicillium/metabolismo
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/toxicidade
Bovinos
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Citrinina/química
Citrinina/toxicidade
Relação Dose-Resposta a Droga
Interações Medicamentosas/fisiologia
Macrófagos/efeitos dos fármacos
Micotoxinas/química
Micotoxinas/toxicidade
Ocratoxinas/química
Ocratoxinas/toxicidade
Penicillium/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Mycotoxins); 0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170129
[St] Status:MEDLINE


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[PMID]:28108327
[Au] Autor:Chen S; Wang J; Wang Z; Lin X; Zhao B; Kaliaperumal K; Liao X; Tu Z; Li J; Xu S; Liu Y
[Ad] Endereço:Department of Chemistry, Jinan University, Guangzhou 510632, China; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Ecology/Guangdong Key Laboratory of Marine Matria Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Gua
[Ti] Título:Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation.
[So] Source:Fitoterapia;117:71-78, 2017 Mar.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Five new compounds, including a cytotoxic dimeric isocoumarin, bipenicilisorin (1), a merosesquiterpenoid, yaminterritrem C (2), a citrinin dimer, penicitrinone F (3), a alkaloid, terremide D (4), and a δ-valerolacton, (E)-4-(propen-1-yl)-5,6-dihydro-2H-pyran-2-one (5), along with ten known compounds (6-15) were isolated from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that 1 exhibited significant cytotoxic activities against K562, A549, and Huh-7 cell lines with IC values of 6.78, 6.94, and 2.59µM, respectively. Compound 3 exhibited moderate inhibitory activity against EV71 with IC value of 14.50µM. In addition, 13 and 14 showed specific COX-2 inhibitory activities with IC values of 1.09 and 1.97µM, respectively.
[Mh] Termos MeSH primário: Citrinina/química
Penicillium chrysogenum/química
[Mh] Termos MeSH secundário: Alcaloides/química
Alcaloides/isolamento & purificação
Antineoplásicos/química
Antineoplásicos/isolamento & purificação
Linhagem Celular Tumoral
Citrinina/análogos & derivados
Citrinina/isolamento & purificação
Cristalografia por Raios X
Inibidores de Ciclo-Oxigenase/química
Inibidores de Ciclo-Oxigenase/isolamento & purificação
Seres Humanos
Concentração Inibidora 50
Isocumarinas/química
Isocumarinas/isolamento & purificação
Estrutura Molecular
Água do Mar/microbiologia
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents); 0 (Cyclooxygenase Inhibitors); 0 (Isocoumarins); 0 (Sesquiterpenes); 0 (penicitrinone F); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE



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