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  1 / 103 MEDLINE  
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[PMID]:28772205
[Au] Autor:Choi PJ; O Y; Her JH; Yun E; Song GY; Oh S
[Ad] Endereço:Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea.
[Ti] Título:Anti-proliferative activity of CGK012 against multiple myeloma cells via Wnt/ß-catenin signaling attenuation.
[So] Source:Leuk Res;60:103-108, 2017 Sep.
[Is] ISSN:1873-5835
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aberrant activation of Wnt/ß-catenin signaling is involved in the development of multiple myeloma; thus, this signaling pathway is a potential target for the development of therapeutics for this malignancy. Here, we performed cell-based chemical screening and found that CGK012, a pyranocoumarin compound, suppressed the Wnt3a-CM-mediated activation of ß-catenin response transcription. CGK012 induced ß-catenin phosphorylation at Ser33/Ser37/Thr41, leading to proteasomal degradation and reducing the level of intracellular ß-catenin. Furthermore, CGK012 consistently decreased the amount of ß-catenin and repressed the expression of cyclin D1, c-myc, and axin-2 (downstream target genes of ß-catenin) in RPMI-8226 multiple myeloma cells. In addition, CGK012 inhibited the proliferation of RPMI-8226 cells and promoted apoptosis, as indicated by the increase in the population of Annexin V-FITC-stained cells and caspase-3/7 activity. These findings suggest that CGK012 could exert antiproliferative activity against multiple myeloma cells by attenuating the Wnt/ß-catenin pathway; thus, it may have potential as a therapeutic agent for multiple myeloma treatment.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Carbamatos/farmacologia
Proliferação Celular/efeitos dos fármacos
Cumarínicos/farmacologia
Mieloma Múltiplo/patologia
Piranocumarinas/farmacologia
Via de Sinalização Wnt/efeitos dos fármacos
beta Catenina/metabolismo
[Mh] Termos MeSH secundário: Antineoplásicos/uso terapêutico
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Seres Humanos
Mieloma Múltiplo/tratamento farmacológico
Mieloma Múltiplo/metabolismo
Fosforilação
Piranocumarinas/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (CGK012); 0 (CTNNB1 protein, human); 0 (Carbamates); 0 (Coumarins); 0 (Pyranocoumarins); 0 (beta Catenin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE


  2 / 103 MEDLINE  
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[PMID]:28321891
[Au] Autor:Kang A; Xie T; Zhu D; Dong Y; Wen H; Pei Y; Shan J; Di L
[Ad] Endereço:Jiangsu Key Laboratory of Pediatric Respiratory Disease, State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, China.
[Ti] Título:Comparative pharmacokinetic study of pyranocoumarins and khellactone in normal and acute lung injury rats after oral administration of Peucedanum praeruptorum Dunn extracts using a rapid and sensitive liquid chromatography-tandem mass spectrometry method.
[So] Source:Biomed Chromatogr;31(10), 2017 Oct.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pyranocoumarins are the main constitutes in Peucedanum praeruptorum Dunn and possess various biological activities. In this article, we developed and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry method for the targeted quantification of the pyranocoumarins, praeruptorin A, praeruptorin B and praeruptorin E, and khellactone, which is a common metabolite of these pyranocoumarins in rat plasma samples. We then performed a comparative pharmacokinetic study of these pyranocoumarins and khellactone in normal and lipopolysaccharide-induced acute lung injury (ALI) in rats following oral administration of P. praeruptorum Dunn extracts. Calibration curves gave desirable linearity (r > 0.99) and the lower limit of quantifications were sufficient for quantitative analysis. The precision and accuracy were assessed by intra-batch and inter-batch assays, and the relative standard deviations were all within 10.23% and the accuracy (relative error) was between -5.52% and 8.68%. The extraction recoveries, matrix effects and stability were also acceptable. The pharmacokinetic study revealed that the area under the concentration-time curve (0-t) of khellactone in ALI rats was significantly decreased compared with the normal rats. Meanwhile, the systemic exposures of these pyranocoumarins were slightly higher in the ALI rats than those in normal rats were. The pharmacokinetic study in the pathological state might provide information that was more comprehensive to guide the clinical usage of P. praeruptorum Dunn.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/metabolismo
Cromatografia Líquida/métodos
Cumarínicos/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Piranocumarinas/farmacocinética
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Administração Oral
Animais
Cumarínicos/análise
Cumarínicos/sangue
Cumarínicos/química
Medicamentos de Ervas Chinesas/administração & dosagem
Limite de Detecção
Modelos Lineares
Pulmão/química
Masculino
Piranocumarinas/análise
Piranocumarinas/sangue
Piranocumarinas/química
Ratos
Ratos Sprague-Dawley
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Drugs, Chinese Herbal); 0 (Pyranocoumarins); 0 (khellactone)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171009
[Lr] Data última revisão:
171009
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3977


  3 / 103 MEDLINE  
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[PMID]:27706093
[Au] Autor:Kirsch G; Abdelwahab AB; Chaimbault P
[Ad] Endereço:SRSMC, UMR 7565, Groupe HeCRIN, ICPM, 1 boulevard Arago, 57070 Metz, France. gilbert.kirsch@univ-lorraine.fr.
[Ti] Título:Natural and Synthetic Coumarins with Effects on Inflammation.
[So] Source:Molecules;21(10), 2016 Oct 02.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this review, we will present the different aspects of coumarins and derivatives, from natural origins or synthetically prepared, and their action on inflammation. Coumarins and also furo- and pyranocoumarins are found in many different plants. These compounds are very often investigated for antioxidant properties. Other biological properties are also possible and anti-inflammation activity is one of these. As coumarins are also available quite easily via synthesis, natural ones can be prepared this way but derivatives with special substituents are also feasible. A review on the same topic appeared in 2004 and our contribution will take into account everything published since then.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Cumarínicos/química
Cumarínicos/farmacologia
Inflamação/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Cumarínicos/síntese química
Furocumarinas/farmacologia
Seres Humanos
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Piranocumarinas/farmacologia
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Coumarins); 0 (Furocoumarins); 0 (Plant Extracts); 0 (Pyranocoumarins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE


  4 / 103 MEDLINE  
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[PMID]:27527830
[Au] Autor:Gómez-Robledo HB; Cruz-Sosa F; Bernabé-Antonio A; Guerrero-Analco A; Olivares-Romero JL; Alonso-Sánchez A; Villafán E; Ibarra-Laclette E
[Ad] Endereço:Facultad de Ciencias de la Salud, Universidad Anáhuac, 52786, Estado de México, México.
[Ti] Título:Identification of candidate genes related to calanolide biosynthesis by transcriptome sequencing of Calophyllum brasiliense (Calophyllaceae).
[So] Source:BMC Plant Biol;16(1):177, 2016 Aug 15.
[Is] ISSN:1471-2229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Calophyllum brasiliense is highlighted as an important resource of calanolides, which are dipyranocoumarins that inhibit the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). Despite having great medicinal importance, enzymes involved in calanolide, biosynthesis and the pathway itself, are still largely unknown. Additionally, no genomic resources exist for this plant species. RESULTS: In this work, we first analyzed the transcriptome of C. brasiliense leaves, stem, and roots using a RNA-seq strategy, which provided a dataset for functional gene mining. According to the structures of the calanolides, putative biosynthetic pathways were proposed. Finally, candidate unigenes in the transcriptome dataset, potentially involved in umbelliferone and calanolide (angular pyranocoumarin) biosynthetic pathways, were screened using mainly homology-based BLAST and phylogenetic analyses. CONCLUSIONS: The unigene dataset that was generated in this study provides an important resource for further molecular studies of C. brasiliense, especially for functional analysis of candidate genes involved in the biosynthetic pathways of linear and angular pyranocoumarins.
[Mh] Termos MeSH primário: Calophyllum/genética
Proteínas de Plantas/genética
Piranocumarinas/metabolismo
[Mh] Termos MeSH secundário: Calophyllum/classificação
Calophyllum/metabolismo
Perfilação da Expressão Gênica
Filogenia
Proteínas de Plantas/metabolismo
Transcriptoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Pyranocoumarins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE
[do] DOI:10.1186/s12870-016-0862-9


  5 / 103 MEDLINE  
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[PMID]:27473055
[Au] Autor:Waziri PM; Abdullah R; Yeap SK; Omar AR; Kassim NK; Malami I; How CW; Etti IC; Abu ML
[Ad] Endereço:MAKNA Cancer Research Laboratory, Institute of Bioscience, University Putra Malaysia, Serdang, Selangor, Malaysia. petermwaziri@gmail.com.
[Ti] Título:Clausenidin induces caspase-dependent apoptosis in colon cancer.
[So] Source:BMC Complement Altern Med;16:256, 2016 Jul 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clausena excavata Burm.f. is a shrub traditionally used to treat cancer patients in Asia. The main bioactive chemical components of the plant are alkaloids and coumarins. In this study, we isolated clausenidin from the roots of C. excavata to determine its apoptotic effect on the colon cancer (HT-29) cell line. METHOD: We examined the effect of clausenidin on cell viability, ROS generation, DNA fragmentation, mitochondrial membrane potential in HT-29 cells. Ultrastructural analysis was conducted for morphological evidence of apoptosis in the treated HT-29 cells. In addition, we also evaluated the effect of clausenidin treatment on the expression of caspase 3 and 9 genes and proteins in HT-29 cells. RESULT: Clausenidin induced a G0/G1 cell cycle arrest in HT-29 cells with significant (p < 0.05) dose-dependent increase in apoptotic cell population. The DNA fragmentation assay also showed apoptotic features in the clausenidin-treated HT-29 cells. Clausenidin treatment had caused significant (p < 0.05) increases in the expression of caspase 9 protein and gene in HT-29 cells and mitochondrial ROS and mitochondrial membrane depolarization. The results suggest the involvement of the mitochondria in the caspase-dependent apoptosis in clausenidin-treated colon cancer cells. CONCLUSION: Clausenidin induces a caspase-dependent apoptosis in colon cancers through the stimulation of the mitochondria. The study demonstrates the potential of clausenidin for use in the treatment of colon cancers.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Caspases/metabolismo
Clausena/química
Neoplasias do Colo/metabolismo
Extratos Vegetais/farmacologia
Piranocumarinas/farmacologia
[Mh] Termos MeSH secundário: Ciclo Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Fragmentação do DNA/efeitos dos fármacos
Expressão Gênica/efeitos dos fármacos
Células HT29
Seres Humanos
Extratos Vegetais/química
Piranocumarinas/química
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Pyranocoumarins); 0 (Reactive Oxygen Species); EC 3.4.22.- (Caspases)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160731
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1247-1


  6 / 103 MEDLINE  
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[PMID]:27289140
[Au] Autor:Xia HM; Li CJ; Yang JZ; Ma J; Li Y; Li L; Zhang DM
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China; Taishan Scholar-Distinguished Experts Position, Key Disciplines on Analysis of Traditional Chinese
[Ti] Título:Hepatoprotective pyranocoumarins from the stems of Clausena emarginata.
[So] Source:Phytochemistry;130:238-43, 2016 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seven pyranocoumarins, clauemarmarins A-G, along with 6 known analogues were isolated from the stems of Clausena emarginata. Their structures were elucidated by extensive spectroscopic analyses, and the absolute stereochemistries at C-6″ of clauemarmarin B, C and D and the absolute configurations of clauemarmarin E, F and G were determined by ECD experiments. Compounds clauemarmarin C, D and two known analogues exhibited hepatoprotective activities against DL-galactosamine-induced damage in WB-F344 cells at the concentration of 10 µM.
[Mh] Termos MeSH primário: Clausena/química
Fígado/efeitos dos fármacos
Caules de Planta/química
Piranocumarinas/isolamento & purificação
Piranocumarinas/farmacologia
[Mh] Termos MeSH secundário: Alcaloides/química
Galactosamina/farmacologia
Piranocumarinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Pyranocoumarins); 7535-00-4 (Galactosamine)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160613
[St] Status:MEDLINE


  7 / 103 MEDLINE  
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[PMID]:27286335
[Au] Autor:Skalicka-Wozniak K; Mroczek T; Walasek M; Glowniak K
[Ad] Endereço:Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, Lublin, Poland.
[Ti] Título:Efficient Isolation of Dihydropyranocoumarins and Simple Coumarins from Mutellina purpurea Fruits.
[So] Source:Planta Med;82(11-12):1105-9, 2016 Jul.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:For the first time, the separation of coumarin derivatives from the petroleum ether extract of the fruits of Mutellina purpurea through high-performance countercurrent chromatography (HPCCC) is described. Four compounds, pteryxin (1; 2.72 mg), hyuganin C (2; 7.94 mg), osthol (3; 4.30 mg), and hyuganin A (4; 3.09 mg), were obtained in a single run following the injection of crude extract (300 mg). Additionally, auraptenol (5) and hyuganin D (6) were identified using LC-ESI-(Q)TOF-MS. The structures of the isolated compounds were elucidated through spectroscopic (NMR and MS) methods. This is apparently the first report of the identification of dihydropyranocoumarins in this plant, and the first time that HPCCC was used to separate them.
[Mh] Termos MeSH primário: Apiaceae/química
Cumarínicos/isolamento & purificação
Piranocumarinas/isolamento & purificação
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Cumarínicos/química
Distribuição Contracorrente/métodos
Estrutura Molecular
Extratos Vegetais/química
Polônia
Piranocumarinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coumarins); 0 (Plant Extracts); 0 (Pyranocoumarins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170316
[Lr] Data última revisão:
170316
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-108738


  8 / 103 MEDLINE  
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[PMID]:27080944
[Au] Autor:Zhang J; Li L; Tang S; Zhang Y; Markiewski M; Xing C; Jiang C; Lü J
[Ad] Endereço:* Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.
[Ti] Título:Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice.
[So] Source:Am J Chin Med;44(2):321-53, 2016.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:Herbal products containing Korean Angelica gigas Nakai (AGN) root extract are marketed as dietary supplements for memory enhancement, pain killing, and female menopausal symptom relief. We have shown the anticancer activities of AGN supplements in mouse models. To facilitate human anticancer translational research, we characterized the tissue distribution of AGN marker pyranocoumarin compounds decursin (D) and decursinol angelate (DA) ([Formula: see text]% in AGN) and their metabolite decursinol (DOH), assessed the safety of sub-chronic AGN dietary exposure in mice, and explored its impact on plasma aqueous metabolites and the prostate transcriptome. The data show that after a gavage dose, plasma contained readily detectable DOH, but little D and DA, mirroring patterns in the liver. Extra-hepatic tissues retained greater levels of DA and D than the liver did. For sub-chronic exposures, male mice were provided ad libitum AIN93M-pellet diets with 0.5 and 1% AGN for six weeks. No adverse effects were observed on the plasma biochemistry markers of liver and kidney integrity in spite of their enlargement. Histopathological examinations of the liver, kidney and other visceral organs did not reveal tissue abnormalities. Metabolomic assessment of plasma from mice fed the 1%-AGN diet suggested metabolic shifts of key amino acids especially in the methionine-cysteine cycle, purine cycle, and glycolysis-citrate cycle. Prostate transcriptomic profiling identified gene signature changes in the metabolisms of drugs, lipids and cellular energetics, neuro-muscular features, immunity and inflammation, and tumor suppressor/oncogene balance. The safety profile was corroborated with a daily [Formula: see text] injection of AGN extract (100-300[Formula: see text]mg/kg) for four weeks, which resulted in much greater systemic pyranocoumarin exposure than the dietary route did.
[Mh] Termos MeSH primário: Angelica/química
Antineoplásicos Fitogênicos
Suplementos Nutricionais
Metaboloma
Extratos Vegetais/farmacologia
Próstata/metabolismo
Piranocumarinas/metabolismo
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Benzopiranos/metabolismo
Butiratos/metabolismo
Feminino
Injeções Intraperitoneais
Masculino
Camundongos Endogâmicos C57BL
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/química
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Benzopyrans); 0 (Butyrates); 0 (Plant Extracts); 0 (Pyranocoumarins); E95RTO3YQR (decursin)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X16500191


  9 / 103 MEDLINE  
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[PMID]:26849943
[Au] Autor:Khan S; Choi RJ; Lee J; Kim YS
[Ad] Endereço:Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan; The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada; College of Pharmacy, Seoul National University, Seoul, Republic of Korea. Electronic address: skhan@qau.edu
[Ti] Título:Attenuation of neuropathic pain and neuroinflammatory responses by a pyranocoumarin derivative, anomalin in animal and cellular models.
[So] Source:Eur J Pharmacol;774:95-104, 2016 Mar 05.
[Is] ISSN:1879-0712
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study investigated the neuropathic pain, anti-neuroinflammatory and neuroprotective properties of a pyranocoumarin derivative (anomalin) in in vivo and in vitro models. An in vivo streptozotocin (STZ)-induced diabetic neuropathic pain model demonstrated that anomalin significantly suppressed neuropathic pain in mice. To identify the molecular mechanism of the anti-neuropathic pain activity of anomalin, sodium-nitroprusside (SNP)-induced neuroinflammation in neuro-2a (N2a) cells was further investigated in signaling pathways. The effects of anomalin against SNP-induced toxicity, nitrite production and related mRNA gene expression (iNOS and COX-2) were considerably reduced by anomalin in the SNP-induced N2a cells. In the molecular signaling pathway, anomalin effectively blocked the SNP-induced activation of the IKKα/ß, IκBα, ERK1/2 and p38 MAPK pathways. Furthermore, anomalin remarkably reduced the increase in the SNP-induced nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway. Additionally, the pro-inflammatory cytokines level was remarkably inhibited by anomalin in high glucose-induced DRG primary neurons and SNP-induced N2a cells. These findings indicate that anomalin has anti-neuropathic pain, anti-neuroinflammatory and neuroprotective effects against STZ-induced diabetic type I neuropathic pain and SNP-induced in neuronal cell models via the inactivation of the NF-κB, Nrf2 and MAPK signaling pathways.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Cumarínicos/química
Cumarínicos/farmacologia
Neuralgia/tratamento farmacológico
Piranocumarinas/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/uso terapêutico
Linhagem Celular Tumoral
Temperatura Baixa/efeitos adversos
Cumarínicos/uso terapêutico
Ciclo-Oxigenase 2/genética
Citocinas/metabolismo
Diabetes Mellitus Tipo 1/complicações
Modelos Animais de Doenças
Gânglios Espinais/efeitos dos fármacos
Gânglios Espinais/patologia
Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos
Inflamação/tratamento farmacológico
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Masculino
Camundongos
Camundongos Endogâmicos ICR
NF-kappa B/metabolismo
Neuralgia/complicações
Neuralgia/metabolismo
Neuralgia/patologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Neurônios/patologia
Óxido Nítrico/biossíntese
Óxido Nítrico Sintase Tipo II/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Coumarins); 0 (Cytokines); 0 (NF-kappa B); 0 (Pyranocoumarins); 0 (RNA, Messenger); 31C4KY9ESH (Nitric Oxide); 81740-07-0 (anomalin); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.99.1 (Cyclooxygenase 2)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160207
[St] Status:MEDLINE


  10 / 103 MEDLINE  
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[PMID]:26824689
[Au] Autor:Chakthong S; Bindulem N; Raknai S; Yodwaree S; Kaewsanee S; Kanjana-Opas A
[Ad] Endereço:a Faculty of Science, Department of Chemistry , Prince of Songkla University , Hat Yai, Songkhla , Thailand.
[Ti] Título:Carbazole-pyranocoumarin conjugate and two carbazole alkaloids from the stems of Clausena excavata.
[So] Source:Nat Prod Res;30(15):1690-7, 2016 Aug.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A carbazole-pyranocoumarin conjugate, carbazomarin B (1), and two carbazole alkaloids, 6-methoxymukonidine (2) and 2-hydroxy-3-methoxycarbazole (3), together with 27 known compounds (4-30), were isolated from the stems of Clausena excavata. Their structures have been elucidated by spectroscopic analyses. Compound 2 showed moderate cytotoxicity to HuCCA-1, MOLT-3 and HepG2 cancer cell lines with IC50 values of 15.09-28.50 µg/mL, but none to A549 cell line. Heptaphylline (6) and nordentatin (23) were found to show moderate cytotoxic activity against HepG2 cell line with IC50 values of 12.33 and 11.33, respectively, while clausine K (27) exhibited strong cytotoxicity with IC50 value of 1.05 µg/mL, better than a standard drug (etoposide, IC50 13.40 µg/mL).
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antineoplásicos Fitogênicos/isolamento & purificação
Carbazóis/isolamento & purificação
Clausena/química
Piranocumarinas/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Carbazóis/química
Carbazóis/farmacologia
Células Hep G2
Seres Humanos
Espectroscopia de Ressonância Magnética
Caules de Planta/química
Piranocumarinas/química
Piranocumarinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Carbazoles); 0 (Pyranocoumarins); 0 (heptaphylline)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1135143



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