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  1 / 2458 MEDLINE  
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[PMID]:29367480
[Au] Autor:Mingyai S; Srikaeo K; Kettawan A; Singanusong R; Nakagawa K; Kimura F; Ito J
[Ad] Endereço:Department of Agro-Industry, Faculty of Agriculture, Natural Resources and Environment, Naresuan University.
[Ti] Título:Effects of Extraction Methods on Phytochemicals of Rice Bran Oils Produced from Colored Rice.
[So] Source:J Oleo Sci;67(2):135-142, 2018 Feb 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Rice bran oil (RBO) especially from colored rice is rich in phytochemicals and has become popular in food, cosmetic, nutraceutical and pharmaceutical applications owing to its offering health benefits. This study determined the contents of phytochemicals including oryzanols, phytosterols, tocopherols (Toc) and tocotrienols (T3) in RBOs extracted using different methods namely cold-press extraction (CPE), solvent extraction (SE) and supercritical CO extraction (SC-CO ). Two colored rice, Red Jasmine rice (RJM, red rice) and Hom-nin rice (HN, black rice), were studied in comparison with the popular Thai fragrant rice Khao Dawk Mali 105 (KDML 105, white rice). RBOs were found to be the rich source of oryzanols, phytosterols, Toc and T3. Rice varieties had a greater effect on the phytochemicals concentrations than extraction methods. HN rice showed the significantly highest concentration of all phytochemicals, followed by RJM and KDML 105 rice, indicating that colored rice contained high concentration of phytochemicals in the oil than non-colored rice. The RBO samples extracted by the CPE method had a greater concentration of the phytochemicals than those extracted by the SC-CO and SE methods, respectively. In terms of phytochemical contents, HN rice extracted using CPE method was found to be the best.
[Mh] Termos MeSH primário: Extração Líquido-Líquido/métodos
Oryza/química
Compostos Fitoquímicos/isolamento & purificação
Óleo de Farelo de Arroz/análise
[Mh] Termos MeSH secundário: Fenilpropionatos/análise
Fenilpropionatos/isolamento & purificação
Compostos Fitoquímicos/análise
Fitosteróis/análise
Fitosteróis/isolamento & purificação
Tocoferóis/análise
Tocoferóis/isolamento & purificação
Tocotrienóis/análise
Tocotrienóis/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenylpropionates); 0 (Phytochemicals); 0 (Phytosterols); 0 (Tocotrienols); LZO6K1506A (Rice Bran Oil); R0ZB2556P8 (Tocopherols); SST9XCL51M (gamma-oryzanol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess17122


  2 / 2458 MEDLINE  
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[PMID]:29313349
[Au] Autor:Lu Y; Li H; Geng Y
[Ad] Endereço:Key Laboratory of Food Nutrition and Safety of SDNU, Provincial Key Laboratory of Animal Resistant Biology, College of Life Science, Shandong Normal University , Jinan 250014, China.
[Ti] Título:Analysis of the Effects of δ-Tocopherol on RAW264.7 and K562 Cells Based on H NMR Metabonomics.
[So] Source:J Agric Food Chem;66(4):1039-1046, 2018 Jan 31.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:δ-Tocopherol (δ-TOH) is a form of vitamin E with higher bioactivity. In this study, we studied the bioactivity of δ-TOH using the IC of δ-TOH on RAW264.7 (80 µM) and K562 (110 µM) cells. We compared the differential metabolites from the cell lines with and without δ-TOH treatment by H NMR metabonomics analysis. It was found that δ-TOH affected the protein biosynthesis, betaine metabolism, and urea cycle in various ways in both cell lines. Metabolic levels of the cell lines were changed after treatment with δ-TOH as differential metabolites were produced. The betaine level in RAW264.7 cells was reduced significantly, while the l-lactic acid level in K562 cells was significantly enhanced. The metabolic changes might contribute to the switch of the respiration pattern from aerobic respiration to anaerobic respiration in K562 cells. These results are helpful in further understanding the subtoxicity of δ-TOH.
[Mh] Termos MeSH primário: Espectroscopia de Ressonância Magnética
Metabolômica/métodos
Tocoferóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Betaína/análise
Betaína/metabolismo
Seres Humanos
Células K562
Ácido Láctico/análise
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Redes e Vias Metabólicas/efeitos dos fármacos
Camundongos
Biossíntese de Proteínas/efeitos dos fármacos
Proteínas
Células RAW 264.7
Ureia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Proteins); 33X04XA5AT (Lactic Acid); 3SCV180C9W (Betaine); 8W8T17847W (Urea); JU84X1II0N (delta-tocopherol); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b04667


  3 / 2458 MEDLINE  
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[PMID]:28463479
[Au] Autor:Hong CY; Ryu SH; Jeong H; Lee SS; Kim M; Choi IG
[Ad] Endereço:Division of Wood Chemistry & Microbiology, Department of Forest Products, National Institute of Forest Science , Seoul, Republic of Korea.
[Ti] Título:Phanerochaete chrysosporium Multienzyme Catabolic System for in Vivo Modification of Synthetic Lignin to Succinic Acid.
[So] Source:ACS Chem Biol;12(7):1749-1759, 2017 Jul 21.
[Is] ISSN:1554-8937
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Whole cells of the basidiomycete fungus Phanerochaete chrysosporium (ATCC 20696) were applied to induce the biomodification of lignin in an in vivo system. Our results indicated that P. chrysosporium has a catabolic system that induces characteristic biomodifications of synthetic lignin through a series of redox reactions, leading not only to the degradation of lignin but also to its polymerization. The reducing agents ascorbic acid and α-tocopherol were used to stabilize the free radicals generated from the ligninolytic process. The application of P. chrysosporium in combination with reducing agents produced aromatic compounds and succinic acid as well as degraded lignin polymers. P. chrysosporium selectively catalyzed the conversion of lignin to succinic acid, which has an economic value. A transcriptomic analysis of P. chrysosporium suggested that the bond cleavage of synthetic lignin was caused by numerous enzymes, including extracellular enzymes such as lignin peroxidase and manganese peroxidase, and that the aromatic compounds released were metabolized in both the short-cut and classical tricarboxylic acid cycles of P. chrysosporium. In conclusion, P. chrysosporium is suitable as a biocatalyst for lignin degradation to produce a value-added product.
[Mh] Termos MeSH primário: Lignina/metabolismo
Complexos Multienzimáticos/química
Phanerochaete/enzimologia
Ácido Succínico/síntese química
[Mh] Termos MeSH secundário: Ácido Ascórbico/química
Radicais Livres
Lignina/química
Peso Molecular
Nitrobenzenos/química
Oxirredução
Phanerochaete/metabolismo
Ácido Succínico/química
Ácido Succínico/metabolismo
Tocoferóis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Free Radicals); 0 (Multienzyme Complexes); 0 (Nitrobenzenes); 9005-53-2 (Lignin); AB6MNQ6J6L (Succinic Acid); E57JCN6SSY (nitrobenzene); PQ6CK8PD0R (Ascorbic Acid); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1021/acschembio.7b00046


  4 / 2458 MEDLINE  
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[PMID]:28873657
[Au] Autor:Petropoulos SA; Fernandes Â; Vasileios A; Ntatsi G; Barros L; Ferreira ICFR
[Ad] Endereço:Laboratory of Vegetable Production, University of Thessaly, Fytokou Street, 38446 N. Ionia, Magnissia, Greece. Electronic address: fangio57gr@gmail.com.
[Ti] Título:Chemical composition and antioxidant activity of Cichorium spinosum L. leaves in relation to developmental stage.
[So] Source:Food Chem;239:946-952, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present study, chemical composition and bioactivity of Cichorium spinosum leaves were examined at different growth stages for optimum harvest stage and end-use assessment. Total fresh weight and number of leaves were higher at 4th growth stage; however, at this stage the end-use is not indicated for raw consumption but mostly for pickled or dried products. Regarding chemical composition, the highest content of tocopherols and minerals was observed in the 1st growth stage, whereas sugars content was the highest in 3rd and 4th growth stage. Polyunsaturated fatty acids content was the highest during the first two growth stages, whereas antioxidant activity, phenolic acids and total phenolic compounds content in the 3rd stage. In conclusion, the results of this study indicate that chemical composition of C. spinosum is highly depended on development stage, and harvest stage should be considered for alternative uses of end-products with high bioactivity.
[Mh] Termos MeSH primário: Asteraceae
[Mh] Termos MeSH secundário: Antioxidantes
Fenóis
Folhas de Planta
Tocoferóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  5 / 2458 MEDLINE  
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[PMID]:28814399
[Au] Autor:White WS; Zhou Y; Crane A; Dixon P; Quadt F; Flendrig LM
[Ad] Endereço:Departments of Food Science and Human Nutrition and wswhite@iastate.edu.
[Ti] Título:Modeling the dose effects of soybean oil in salad dressing on carotenoid and fat-soluble vitamin bioavailability in salad vegetables.
[So] Source:Am J Clin Nutr;106(4):1041-1051, 2017 Oct.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previously, we showed that vegetable oil is necessary for carotenoid absorption from salad vegetables. Research is needed to better define the dose effect and its interindividual variation for carotenoids and fat-soluble vitamins. The objective was to model the dose-response relation between the amount of soybean oil in salad dressing and the absorption of ) carotenoids, phylloquinone, and tocopherols in salad vegetables and ) retinyl palmitate formed from the provitamin A carotenoids. Women ( = 12) each consumed 5 vegetable salads with salad dressings containing 0, 2, 4, 8, or 32 g soybean oil. Blood was collected at selected time points. The outcome variables were the chylomicron carotenoid and fat-soluble vitamin area under the curve (AUC) and maximum content in the plasma chylomicron fraction ( ). The individual-specific and group-average dose-response relations were investigated by fitting linear mixed-effects random coefficient models. Across the entire 0-32-g range, soybean oil was linearly related to the chylomicron AUC and values for α-carotene, lycopene, phylloquinone, and retinyl palmitate. Across 0-8 g of soybean oil, there was a linear increase in the chylomicron AUC and values for ß-carotene. Across a more limited 0-4-g range of soybean oil, there were minor linear increases in the chylomicron AUC for lutein and α- and total tocopherol. Absorption of all carotenoids and fat-soluble vitamins was highest with 32 g oil ( < 0.002). For 32 g oil, the interindividual rank order of the chylomicron AUCs was consistent across the carotenoids and fat-soluble vitamins ( < 0.0001). Within the linear range, the average absorption of carotenoids and fat-soluble vitamins could be largely predicted by the soybean oil effect. However, the effect varied widely, and some individuals showed a negligible response. There was a global soybean oil effect such that those who absorbed more of one carotenoid and fat-soluble vitamin also tended to absorb more of the others. This trial was registered at clinicaltrials.gov as NCT02867488.
[Mh] Termos MeSH primário: Carotenoides/farmacocinética
Dieta
Absorção Intestinal/efeitos dos fármacos
Óleo de Soja/administração & dosagem
Verduras/química
Vitamina A/análogos & derivados
Vitaminas/farmacocinética
[Mh] Termos MeSH secundário: Adulto
Área Sob a Curva
Disponibilidade Biológica
Carotenoides/sangue
Quilomícrons
Relação Dose-Resposta a Droga
Feminino
Seres Humanos
Luteína/sangue
Luteína/farmacocinética
Modelos Biológicos
Solubilidade
Óleo de Soja/farmacologia
Tocoferóis/sangue
Tocoferóis/farmacocinética
Vitamina A/sangue
Vitamina K 1/sangue
Vitamina K 1/farmacocinética
Vitaminas/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Chylomicrons); 0 (Vitamins); 11103-57-4 (Vitamin A); 1D1K0N0VVC (retinol palmitate); 36-88-4 (Carotenoids); 45XWE1Z69V (alpha-carotene); 8001-22-7 (Soybean Oil); 84-80-0 (Vitamin K 1); R0ZB2556P8 (Tocopherols); SB0N2N0WV6 (lycopene); X72A60C9MT (Lutein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170818
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.117.153635


  6 / 2458 MEDLINE  
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[PMID]:28764039
[Au] Autor:Gutiérrez LF; Quiñones-Segura Y; Sanchez-Reinoso Z; Díaz DL; Abril JI
[Ad] Endereço:Instituto de Ciencia y Tecnología de Alimentos (ICTA), Universidad Nacional de Colombia Sede Bogotá, Carrera 30 No. 45-03, Edificio 500A, Bogotá, DC 111321, Colombia. Electronic address: lfgutierreza@unal.edu.co.
[Ti] Título:Physicochemical properties of oils extracted from γ-irradiated Sacha Inchi (Plukenetia volubilis L.) seeds.
[So] Source:Food Chem;237:581-587, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study evaluated the physicochemical properties of oils extracted from γ-irradiated Sacha Inchi (Plukenetia volubilis L.) seeds (SIS) at four different doses (0, 1, 5 and 8kGy). Fatty acid composition, tocopherol content, FTIR spectra, density, refractive index, acidity, peroxide value (PV), p-anisidine index (p-An), oxidation induction period (IP), and color were chosen as test parameters. Overall, the irradiation treatment did not significantly affect the physicochemical properties of the Sacha Inchi oils, although slight increases were found in the PV and p-An, as the irradiation dose increased. γ-Irradiation led to a decrease in the concentration of γ- and δ-tocopherol, as well as in the IP. However, according to the FTIR analyses, the functional groups of the oils were not significantly affected by the γ-irradiation. These results suggest that γ-irradiation at 1-5kGy, might be recommended as a suitable eco-friendly technology for the preservation of SIS used for oil production.
[Mh] Termos MeSH primário: Euphorbiaceae
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Fenômenos Químicos
Ácidos Graxos
Sementes
Tocoferóis
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Plant Oils); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  7 / 2458 MEDLINE  
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[PMID]:28756671
[Au] Autor:Irías-Mata A; Stuetz W; Sus N; Hammann S; Gralla K; Cordero-Solano A; Vetter W; Frank J
[Ti] Título:Tocopherols, Tocomonoenols, and Tocotrienols in Oils of Costa Rican Palm Fruits: A Comparison between Six Varieties and Chemical versus Mechanical Extraction.
[So] Source:J Agric Food Chem;65(34):7476-7482, 2017 Aug 30.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Palm oil is one of the richest sources of tocotrienols and may contain other non-tocopherol vitamin E congeners. The vitamin E profiles of fully ripened fruit mesocarp of three Elaeis guineensis, two Elaeis oleifera, and one hybrid O × G palm fruit genotypes from Costa Rica were analyzed by high-performance liquid chromatography with fluorescence detection and gas chromatography-mass spectrometry after mechanical extraction by a screw press and chemical extraction with hexane. γ-Tocotrienol, α-tocotrienol, and α-tocopherol were the most abundant tocochromanols, while other tocopherols (ß-tocopherol, γ-tocopherol, and δ-tocopherol) and α-tocomonoenol were detected at minor concentrations. Significant differences in vitamin E profiles between genotypes were observed, and the variety E. oleifera Quepos (CB9204) had by far the highest content of total tocotrienols (890 µg/g of oil) and total vitamin E (892 µg/g of oil). Chemical extraction with hexane afforded up to 2.5-fold higher vitamin E yields than screw press extraction. α-Tocomonoenol co-eluted with γ-tocopherol in reversed-phase high-performance liquid chromatography analyses and is a possible source of error in the quantification of γ-tocopherol in foods.
[Mh] Termos MeSH primário: Arecaceae/química
Frutas/química
Óleos Vegetais/química
Tocoferóis/química
Tocotrienóis/química
[Mh] Termos MeSH secundário: Arecaceae/classificação
Cromatografia Líquida de Alta Pressão
Costa Rica
Frutas/classificação
Cromatografia Gasosa-Espectrometria de Massas
Óleo de Palmeira
Óleos Vegetais/isolamento & purificação
Tocoferóis/isolamento & purificação
Tocotrienóis/isolamento & purificação
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Oils); 0 (Tocotrienols); 5QUO05548Z (Palm Oil); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170801
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.7b02230


  8 / 2458 MEDLINE  
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[PMID]:28659298
[Au] Autor:Playdon MC; Ziegler RG; Sampson JN; Stolzenberg-Solomon R; Thompson HJ; Irwin ML; Mayne ST; Hoover RN; Moore SC
[Ad] Endereço:Yale School of Public Health, Yale University, New Haven, CT; mary.playdon@nih.gov.
[Ti] Título:Nutritional metabolomics and breast cancer risk in a prospective study.
[So] Source:Am J Clin Nutr;106(2):637-649, 2017 Aug.
[Is] ISSN:1938-3207
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The epidemiologic evidence for associations between dietary factors and breast cancer is weak and etiologic mechanisms are often unclear. Exploring the role of dietary biomarkers with metabolomics can potentially facilitate objective dietary characterization, mitigate errors related to self-reported diet, agnostically test metabolic pathways, and identify mechanistic mediators. The aim of this study was to evaluate associations of diet-related metabolites with the risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. We examined prediagnostic serum concentrations of diet-related metabolites in a nested case-control study in 621 postmenopausal invasive breast cancer cases and 621 matched controls in the multicenter PLCO cohort. We calculated partial Pearson correlations between 617 metabolites and 55 foods, food groups, and vitamin supplements on the basis of the 2015 Dietary Guidelines for Americans and derived from a 137-item self-administered food-frequency questionnaire. Diet-related metabolites ( correlation < 1.47 × 10 ) were evaluated in breast cancer analyses. ORs for the 90th compared with the 10th percentile were calculated by using conditional logistic regression, with body mass index, physical inactivity, other breast cancer risk factors, and caloric intake controlled for (false discovery rate <0.2). Of 113 diet-related metabolites, 3 were associated with overall breast cancer risk (621 cases): caprate (10:0), a saturated fatty acid (OR: 1.77; 95% CI = 1.28, 2.43); γ-carboxyethyl hydrochroman (γ-CEHC), a vitamin E (γ-tocopherol) derivative (OR: 1.64; 95% CI: 1.18, 2.28); and 4-androsten-3ß,17ß-diol-monosulfate (1), an androgen (OR: 1.61; 95% CI: 1.20, 2.16). Nineteen metabolites were significantly associated with estrogen receptor (ER)-positive (ER ) breast cancer (418 cases): 12 alcohol-associated metabolites, including 7 androgens and α-hydroxyisovalerate (OR: 2.23; 95% CI: 1.50, 3.32); 3 vitamin E (tocopherol) derivatives (e.g., γ-CEHC; OR: 1.80; 95% CI: 1.20, 2.70); butter-associated caprate (10:0) (OR: 1.81; 95% CI: 1.23, 2.67); and fried food-associated 2-hydroxyoctanoate (OR: 1.46; 95% CI: 1.03, 2.07). No metabolites were significantly associated with ER-negative breast cancer (144 cases). Prediagnostic serum concentrations of metabolites related to alcohol, vitamin E, and animal fats were moderately strongly associated with ER breast cancer risk. Our findings show how nutritional metabolomics might identify diet-related exposures that modulate cancer risk. This trial was registered at clinicaltrials.gov as NCT00339495.
[Mh] Termos MeSH primário: Neoplasias da Mama/sangue
Dieta
Gorduras na Dieta/sangue
Etanol/sangue
Ácidos Graxos/sangue
Comportamento Alimentar
Tocoferóis/sangue
[Mh] Termos MeSH secundário: Idoso
Androgênios/sangue
Animais
Biomarcadores/sangue
Neoplasias da Mama/etiologia
Manteiga
Estudos de Casos e Controles
Ácidos Decanoicos/sangue
Gorduras na Dieta/efeitos adversos
Suplementos Nutricionais
Etanol/efeitos adversos
Ácidos Graxos/efeitos adversos
Feminino
Seres Humanos
Modelos Logísticos
Metabolômica
Meia-Idade
Estudos Prospectivos
Receptores Estrogênicos/metabolismo
Fatores de Risco
Tocoferóis/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Androgens); 0 (Biomarkers); 0 (Decanoic Acids); 0 (Dietary Fats); 0 (Fatty Acids); 0 (Receptors, Estrogen); 3K9958V90M (Ethanol); 8029-34-3 (Butter); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.3945/ajcn.116.150912


  9 / 2458 MEDLINE  
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[PMID]:28631913
[Au] Autor:Galimov SN; Akhmetov RM; Galimova EF; Bairamgulov FM; Bikkulova LR
[Ad] Endereço:Bashkir State Medical University of Minzdrav of Russia, Ufa, Russia.
[Ti] Título:[Molecular aspects of the impact of the Speroton complex on the male fertility in idiopathic infertility].
[So] Source:Urologiia;(2):88-92, 2017 Jun.
[Is] ISSN:1728-2985
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To characterize the effect of the Speroton complex on the free radical homeostasis in the ejaculate of males of infertile couples and the likelihood of pregnancy in partners. MATERIALS AND METHODS: The study group comprised 30 men aged between 26 and 43 years (mean 33 +/- 4.8 years) with idiopathic infertility. All patients received Speroton one sachet once daily during meals for 3 months. The comparison group consisted of 29 men of fertile age having 1 to 3 healthy children. In infertile men, standard semen parameters including the ejaculate volume, sperm concentration, total count and proportion of abnormal forms were within the normal range. Markers of oxidative damage to ejaculate macromolecules were determined using standard diagnostic testing systems. RESULTS: The patients with idiopathic infertility were found to have statistically significant changes in the degree of chemical modification of ejaculate biopolymers. The level of lipid hydroperoxides in infertile men was significantly higher than in fertile participants. Taking Speroton resulted in the decrease of lipid hydroperoxides to the level that did not differ from that in the control group. Using Speroton was also accompanied by a decrease in the level of the oxidative damage DNA biomarker 8-oxodGu and a tendency toward normalization of the carbonyl modification of the ejaculate proteins. Five married couples in the treatment group reported achieving pregnancy. CONCLUSION: Taking Speroton was associated with the normalization of the balance of pro- and antioxidant processes in the ejaculate, as indicated by a decrease in the oxidative destruction of sperm biopolymers. The revealed molecular mechanism of the drug action is the basis for restoring the fertilizing ability and increasing the likelihood of pregnancy. The treatment effectiveness was 16.7%. Speroton is a promising drug that improves the functional sperm characteristics and contributes to achieving pregnancy in couples with a male infertility factor.
[Mh] Termos MeSH primário: Fertilidade/efeitos dos fármacos
Infertilidade Masculina/tratamento farmacológico
Motilidade Espermática/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Tocoferóis/farmacologia
Tocoferóis/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Contagem de Espermatozoides
Espermatozoides/citologia
Espermatozoides/enzimologia
Tocoferóis/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Speroton complex); R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE


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[PMID]:28566525
[Au] Autor:Gaur S; Kuchan MJ; Lai CS; Jensen SK; Sherry CL
[Ad] Endereço:Abbott Nutrition, Columbus, OH; and.
[Ti] Título:Supplementation with or -α-Tocopherol Differentially Affects the α-Tocopherol Stereoisomer Profile in the Milk and Plasma of Lactating Women.
[So] Source:J Nutr;147(7):1301-1307, 2017 Jul.
[Is] ISSN:1541-6100
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The naturally occurring α-tocopherol stereoisomer α-tocopherol is known to be more bioactive than synthetic α-tocopherol ( -α-tocopherol). However, the influence of this difference on the α-tocopherol stereoisomer profile of human milk is not understood. We investigated whether supplemental α-tocopherol or -α-tocopherol differentially affected the distribution of α-tocopherol stereoisomers in milk and plasma from lactating women. Eighty-nine lactating women aged 19-40 y and with a body mass index (in kg/m ) ≤30 were randomly assigned at 4-6 wk postpartum to receive a daily supplement containing 45.5 mg -α-tocopherol acetate (ARAC), 22.8 mg -α-tocopherol acetate + 20.1 mg -α-tocopherol (MIX), or 40.2 mg α-tocopherol (RRR). Milk and plasma were analyzed for α-tocopherol structural isomers and α-tocopherol stereoisomers at baseline and after 6 wk supplementation with the use of chiral HPLC. There were no significant treatment group or time-dependent changes in milk or plasma α, γ, or δ-tocopherol. α-tocopherol was the most abundant stereoisomer in both milk and plasma in each group. Supplementation changed both milk and plasma percentage α-tocopherol (RRR > MIX > ARAC) ( < 0.05) and percentage non- α-tocopherol (ARAC > MIX > RRR) ( < 0.05). In the RRR group, percentage α-tocopherol increased in milk (mean ± SEM: 78% ± 2.3% compared with 82% ± 1.7%) ( 0.05) and plasma (mean ± SEM: 77% ± 1.8% compared with 87% ± 1%) ( 0.05). In contrast, the percentage α-tocopherol decreased in the MIX and ARAC groups (MIX, 0.05; ARAC, 0.0001), and percentage non- α-tocopherol stereoisomers increased (MIX, 0.05; ARAC, 0.0001) commensurate with an accumulation of α-tocopherol stereoisomers ( < 0.05) in both milk and plasma. Milk and plasma α-tocopherol was positively correlated at baseline ( = 0.67; 0.0001) and 6 wk ( = 0.80; 0.0001). The α-tocopherol supplementation strategy differentially affected the α-tocopherol milk and plasma stereoisomer profile in lactating women. α-tocopherol increased milk and plasma percentage α-tocopherol, whereas -α-tocopherol acetate reduced these percentages. Because α-tocopherol is the most bioactive stereoisomer, investigating the impact of supplement-driven changes in the milk α-tocopherol stereoisomer profile on the α-tocopherol status of breastfed infants is warranted.
[Mh] Termos MeSH primário: Lactação/fisiologia
Leite Humano/química
Tocoferóis/química
Tocoferóis/farmacologia
[Mh] Termos MeSH secundário: Adulto
Suplementos Nutricionais
Feminino
Seres Humanos
Estereoisomerismo
Tocoferóis/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
R0ZB2556P8 (Tocopherols)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.3945/jn.116.245134



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