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[PMID]:28087578
[Au] Autor:Ono M; Sahara N; Kumata K; Ji B; Ni R; Koga S; Dickson DW; Trojanowski JQ; Lee VM; Yoshida M; Hozumi I; Yoshiyama Y; van Swieten JC; Nordberg A; Suhara T; Zhang MR; Higuchi M
[Ad] Endereço:National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
[Ti] Título:Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies.
[So] Source:Brain;140(3):764-780, 2017 Mar 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diverse neurodegenerative disorders are characterized by deposition of tau fibrils composed of conformers (i.e. strains) unique to each illness. The development of tau imaging agents has enabled visualization of tau lesions in tauopathy patients, but the modes of their binding to different tau strains remain elusive. Here we compared binding of tau positron emission tomography ligands, PBB3 and AV-1451, by fluorescence, autoradiography and homogenate binding assays with homologous and heterologous blockades using tauopathy brain samples. Fluorescence microscopy demonstrated intense labelling of non-ghost and ghost tangles with PBB3 and AV-1451, while dystrophic neurites were more clearly detected by PBB3 in brains of Alzheimer's disease and diffuse neurofibrillary tangles with calcification, characterized by accumulation of all six tau isoforms. Correspondingly, partially distinct distributions of autoradiographic labelling of Alzheimer's disease slices with 11C-PBB3 and 18F-AV-1451 were noted. Neuronal and glial tau lesions comprised of 4-repeat isoforms in brains of progressive supranuclear palsy, corticobasal degeneration and familial tauopathy due to N279K tau mutation and 3-repeat isoforms in brains of Pick's disease and familial tauopathy due to G272V tau mutation were sensitively detected by PBB3 fluorescence in contrast to very weak AV-1451 signals. This was in line with moderate 11C-PBB3 versus faint 18F-AV-1451 autoradiographic labelling of these tissues. Radioligand binding to brain homogenates revealed multiple binding components with differential affinities for 11C-PBB3 and 18F-AV-1451, and higher availability of binding sites on progressive supranuclear palsy tau deposits for 11C-PBB3 than 18F-AV-1451. Our data indicate distinct selectivity of PBB3 compared to AV-1451 for diverse tau fibril strains. This highlights the more robust ability of PBB3 to capture wide-range tau pathologies.
[Mh] Termos MeSH primário: Encéfalo
Carbolinas/farmacocinética
Emaranhados Neurofibrilares/patologia
Tomografia por Emissão de Pósitrons
Tauopatias
Proteínas tau/metabolismo
[Mh] Termos MeSH secundário: Autorradiografia
Benzotiazóis/química
Benzotiazóis/farmacocinética
Encéfalo/diagnóstico por imagem
Encéfalo/efeitos dos fármacos
Encéfalo/patologia
Butadienos/farmacocinética
Diagnóstico
Feminino
Fluorescência
Seres Humanos
Masculino
Fenazopiridina/farmacocinética
Ensaio Radioligante
Compostos Radiofarmacêuticos/farmacocinética
Tauopatias/diagnóstico por imagem
Tauopatias/metabolismo
Tauopatias/patologia
Tiadiazóis/farmacocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole); 0 (Benzothiazoles); 0 (Butadienes); 0 (Carbolines); 0 (PBB3 compound); 0 (Radiopharmaceuticals); 0 (Thiadiazoles); 0 (tau Proteins); 273-77-8 (benzo-1,2,3-thiadiazole); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170115
[St] Status:MEDLINE
[do] DOI:10.1093/brain/aww339


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[PMID]:27939517
[Au] Autor:Nordt SP
[Ad] Endereço:Department of Emergency Medicine Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, KAM 100F, Los Angeles, CA 90033, United States. Electronic address: spnordt@hotmail.com.
[Ti] Título:Pyelonephritis following phenazopyridine use.
[So] Source:Am J Emerg Med;35(5):805.e3-805.e4, 2017 May.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We present a case of pyelonephritis following the extended andsolitary use of over-the-counter phenazopyridine in a forty-year-oldfemale. The patient initially had uncomplicated cystitis signs andsymptoms which partially resolved with phenazopyridine and therefore she continued use. She presented to the emergency department with systemicsigns and symptoms of acute pyelonephritis. As phenazopyridine is devoidof antibacterial properties this allowed the lower urinary tractinfection to progress to acute pyelonephritis requiring intravenousantibiotics. Better patient education may preclude this complication.
[Mh] Termos MeSH primário: Anestésicos Locais/uso terapêutico
Antibacterianos/uso terapêutico
Cistite/tratamento farmacológico
Fenazopiridina/uso terapêutico
Pielonefrite/induzido quimicamente
[Mh] Termos MeSH secundário: Adulto
Anestésicos Locais/efeitos adversos
Cistite/psicologia
Progressão da Doença
Feminino
Seres Humanos
Educação de Pacientes como Assunto
Fenazopiridina/efeitos adversos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Anti-Bacterial Agents); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170628
[Lr] Data última revisão:
170628
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27840352
[Au] Autor:Yuri P; Ali Z; Rasyid N; Birowo P
[Ad] Endereço:Department of Surgery, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia. prahara.yuri@gmail.com.
[Ti] Título:Effects of Pipemidic Acid, Phenazopyridine HCL and Sodium Diclofenac on Pain Perception Following Endoscopic Urological Surgery: Double-blinded Randomized-Controlled Trial.
[So] Source:Acta Med Indones;48(3):184-192, 2016 Jul.
[Is] ISSN:0125-9326
[Cp] País de publicação:Indonesia
[La] Idioma:eng
[Ab] Resumo:AIM: to evaluate the analgesic effect, the side effects and the safety of analgesics following endoscopic urological procedure. METHODS: eighty patients who underwent endoscopic urological surgery at Kardinah Hospital, Tegal from June to July 2015 were divided into four groups. The experimental group was administered analgesic for 4 days pipemidic acid (A) 400 mg bid, or phenazopyridine (B) 200 mg tid, or sodium diclofenac (C) 50 mg bid and the control (D) group was administered placebo tid for 4 days. The analgesic effects were assessed using Visual Analog Scale (VAS). Association between variables was assessed using Cramers V and Kruskall Wallis. RESULTS: the endoscopic urological procedures consisted of 30 patients for URS, 6 patients for lithotripsy, 17 patients for TURP, 24 patients for removal JJ stent and 3 patients for cystoscopy. The mean age of group A, B, C and D (control) was 50.1 (13.7), 50.7 (14.8), 49.1 (13.4), and 49.6 (14.3) years, respectively, and follow-up period was 7 days. The VAS score in all experimental groups was less than control group on day 1 to 7 following endoscopic urological procedures (p<0.05). In the experimental group, there was no difference between groups B and C (p>0.05). Group A demonstrated a more favourable analgesic effect than B and C (p<0.05). No serious side effects were detected in any of the cases. CONCLUSION: we conclude that oral analgesics are effective for pain relief following endoscopic urological surgery. Pipemidic acid was found to have a superior analgesic effect than phenazopyridine HCl and sodium diclofenac.
[Mh] Termos MeSH primário: Anestésicos Locais/uso terapêutico
Anti-Infecciosos Urinários/uso terapêutico
Anti-Inflamatórios não Esteroides/uso terapêutico
Diclofenaco/uso terapêutico
Percepção da Dor
Fenazopiridina/uso terapêutico
Ácido Pipemídico/uso terapêutico
Procedimentos Cirúrgicos Urológicos
[Mh] Termos MeSH secundário: Método Duplo-Cego
Endoscopia
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anesthetics, Local); 0 (Anti-Infective Agents, Urinary); 0 (Anti-Inflammatory Agents, Non-Steroidal); 144O8QL0L1 (Diclofenac); K2J09EMJ52 (Phenazopyridine); LT12J5HVR8 (Pipemidic Acid)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170123
[Lr] Data última revisão:
170123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27824741
[Au] Autor:Espaillat-Rijo L; Siff L; Alas AN; Chadi SA; Zimberg S; Vaish S; Davila GW; Barber M; Hurtado EA
[Ad] Endereço:Division of Urogynecology, Lehigh Valley Health Network, Allentown, Pennsylvania; the Departments of Gynecology and Urology, Cleveland Clinic Florida, Weston, Florida; the Department of Gynecology, Cleveland Clinic, Cleveland, Ohio; and the Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Intraoperative Cystoscopic Evaluation of Ureteral Patency: A Randomized Controlled Trial.
[So] Source:Obstet Gynecol;128(6):1378-1383, 2016 Dec.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To compare different modalities to aid in the evaluation of intraoperative ureteral patency on cystoscopy in the postindigo carmine era. METHODS: In a randomized controlled trial, participants undergoing pelvic surgery were randomized into one of four groups: saline distention (control), 10% dextrose distention, oral phenazopyridine, or intravenous sodium fluorescein. Our primary outcome was visibility of the ureteral jets. Secondary outcomes included surgeon satisfaction; adverse reactions including allergies, urinary tract infections, urinary retention, cystoscopy times, and ureteral obstruction; and delayed diagnosis. Participants were followed for 6 weeks. A sample size of 176 participants was planned to demonstrate a 30% difference in the visibility scale. All analyses were performed in an intention-to-treat fashion. RESULTS: From February 25, 2015, through August 2015, 176 participants were enrolled; 174 completed the trial, and two did not undergo intervention. Forty-four participants were included in the phenazopyridine, dextrose, saline, and sodium fluorescein groups. Sodium fluorescein and 10% dextrose resulted in significantly improved visibility and satisfaction when compared with the control group (P<.001 and P=.004, respectively). Dextrose provided the highest satisfaction and phenazopyridine provided lowest, but visibility was not statistically different between the two groups (P=.101). Three ureteral obstructions were identified intraoperatively and none in the postoperative period. Mean total cystoscopy time varied between 4.0 and 4.8 minutes and postoperative urinary retention rate was 50% across all groups. Overall urinary tract infection rate was 24.1%, which was similar between interventions. There were no related adverse events. CONCLUSION: Compared with the control, 10% dextrose and sodium fluorescein resulted in improved visibility and provided significantly more satisfaction in the evaluation for ureteral patency with no considerable increase in operative time or morbidity. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, https://clinicaltrials.gov, NCT02476448.
[Mh] Termos MeSH primário: Cistoscopia
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos
Complicações Intraoperatórias/diagnóstico
Ureter/lesões
Ferimentos e Lesões/diagnóstico
[Mh] Termos MeSH secundário: Administração Intravenosa
Administração Oral
Idoso
Atitude do Pessoal de Saúde
Cistoscopia/efeitos adversos
Cistoscopia/métodos
Feminino
Fluoresceína/administração & dosagem
Fluoresceína/efeitos adversos
Corantes Fluorescentes/administração & dosagem
Corantes Fluorescentes/efeitos adversos
Glucose/administração & dosagem
Glucose/efeitos adversos
Seres Humanos
Cuidados Intraoperatórios
Complicações Intraoperatórias/etiologia
Meia-Idade
Duração da Cirurgia
Fenazopiridina/administração & dosagem
Fenazopiridina/efeitos adversos
Estudos Prospectivos
Obstrução Ureteral/etiologia
Retenção Urinária/etiologia
Infecções Urinárias/etiologia
Ferimentos e Lesões/etiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Fluorescent Dyes); IY9XDZ35W2 (Glucose); K2J09EMJ52 (Phenazopyridine); TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:161109
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE


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[PMID]:27625731
[Au] Autor:Banimahd F; Loo T; Amin M; Ahadiat OR; Chakravarthy B; Lotfipour S
[Ad] Endereço:University of California, Irvine, Department of Emergency Medicine, Irvine, California.
[Ti] Título:A Rare but Important Clinical Presentation of Induced Methemoglobinemia.
[So] Source:West J Emerg Med;17(5):627-9, 2016 Sep.
[Is] ISSN:1936-9018
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Metemoglobinemia/induzido quimicamente
Metemoglobinemia/complicações
Fenazopiridina/envenenamento
Pielonefrite/diagnóstico
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Adulto
Antibacterianos/uso terapêutico
Ceftriaxona/uso terapêutico
Serviço Hospitalar de Emergência
Feminino
Seres Humanos
Pielonefrite/tratamento farmacológico
Pielonefrite/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 75J73V1629 (Ceftriaxone); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170411
[Lr] Data última revisão:
170411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160915
[St] Status:MEDLINE
[do] DOI:10.5811/westjem.2016.6.30504


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[PMID]:27399998
[Au] Autor:Propst K; Tunitsky-Bitton E; OʼSullivan DM; Steinberg AC; LaSala C
[Ad] Endereço:Department of Women's Health, Female Pelvic Medicine and Reconstructive Surgery and Research Administration, Hartford Hospital, Harford, Connecticut.
[Ti] Título:Phenazopyridine for Evaluation of Ureteral Patency: A Randomized Controlled Trial.
[So] Source:Obstet Gynecol;128(2):348-55, 2016 Aug.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the usefulness of phenazopyridine for confirmation of ureteral patency during intraoperative cystoscopy. METHODS: We conducted a randomized controlled trial comparing use of phenazopyridine with no medications for evaluation of ureteral patency during intraoperative cystoscopy in women undergoing pelvic surgery. The primary study outcome was time to visualize ureteral urine efflux. To detect a 3-minute difference with α of 0.05 using a two-sided, two-sample t test and ß 0.80 required 98 patients equally divided into two groups. RESULTS: A total of 104 women were randomized from April to December 2015. Patients in the treatment group tended to be older (P=.02); otherwise, study groups were similar. Time to visualize ureteral urine efflux did not differ between study groups with a mean time of 2 minutes 40 seconds (±2 minutes 38 seconds) in the control group and 2 minutes 53 seconds (±4 minutes 35 seconds) in the treatment group (P=.77). Regarding the surgeon survey, surgeons felt less frustrated and impatient in visualization of ureteral urine efflux in the treatment group compared with the control group (mean response 1.5±0.8 in treatment compared with 2.0±1.0 in control, P=.007), and surgeons felt that the cystoscopy took too long more often in the control than in the treatment group (1.7±0.9 in treatment compared with 2.1±1.0 in control, P=.02). Trial of void result differed significantly between groups with fewer patients in the treatment group failing a void trial (P=.04). There were no adverse events related to phenazopyridine use. CONCLUSION: Preoperative phenazopyridine is a useful and cost-saving medication for use in planned cystoscopy for evaluation of ureteral patency. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, https://clinicaltrials.gov/, NCT02424149.
[Mh] Termos MeSH primário: Corantes
Cistoscopia
Complicações Intraoperatórias/diagnóstico
Fenazopiridina
Ureter/lesões
Ferimentos e Lesões/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Atitude do Pessoal de Saúde
Feminino
Procedimentos Cirúrgicos em Ginecologia/efeitos adversos
Seres Humanos
Cuidados Intraoperatórios
Complicações Intraoperatórias/etiologia
Meia-Idade
Fatores de Tempo
Ferimentos e Lesões/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Coloring Agents); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170608
[Lr] Data última revisão:
170608
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160712
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000001472


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[PMID]:27232418
[Au] Autor:Shargh M; Behnajady MA
[Ad] Endereço:Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran E-mail: behnajady@gmail.com; behnajady@iaut.ac.ir.
[Ti] Título:A high-efficient batch-recirculated photoreactor packed with immobilized TiO2-P25 nanoparticles onto glass beads for photocatalytic degradation of phenazopyridine as a pharmaceutical contaminant: artificial neural network modeling.
[So] Source:Water Sci Technol;73(11):2804-14, 2016.
[Is] ISSN:0273-1223
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, removal efficiency of phenazopyridine (PhP) as a model pharmaceutical contaminant was investigated in a batch-recirculated photoreactor packed with immobilized TiO2-P25 nanoparticles on glass beads. Influence of various operational parameters such as irradiation time, initial concentration of PhP, volume of solution, volumetric flow rate, pH and power of light source was investigated. Results indicated that removal percentage increases with the rise of irradiation time, volumetric flow rate and power of light source but decreases with the rise of initial concentration of PhP and volume of solution. Highest removal percentage was obtained in the natural pH of PhP solution (pH = 5.9). Results of mineralization studies also showed a decreasing trend of total organic carbon (TOC) and producing mineralization products such as NO3(-), NO2(-) and NH4(+). Modeling of the process using artificial neural network showed that the most effective parameters in the degradation of PhP were volume of solution and power of light source. The packed bed photoreactor with TiO2-P25 nanoparticles coated onto glass beads in consecutive repeats have the proper ability for PhP degradation. Therefore, this system can be a promising alternative for the removal of recalcitrant organic pollutants such as PhP from aqueous solutions.
[Mh] Termos MeSH primário: Redes Neurais (Computação)
Fenazopiridina/química
Fotólise
Titânio/química
Poluentes Químicos da Água/química
[Mh] Termos MeSH secundário: Vidro
Nanopartículas/química
Fenazopiridina/efeitos da radiação
Poluentes Químicos da Água/efeitos da radiação
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Water Pollutants, Chemical); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160528
[Lr] Data última revisão:
160528
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE
[do] DOI:10.2166/wst.2016.132


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[PMID]:26867555
[Au] Autor:Tolba MM; Salim MM
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516 Mansoura, Egypt manar2kareem@yahoo.com.
[Ti] Título:Derivative Quotient Spectrophotometry and an Eco-Friendly Micellar Chromatographic Approach with Time-Programmed UV-Detection for the Separation of Two Fluoroquinolones and Phenazopyridine.
[So] Source:J Chromatogr Sci;54(5):776-89, 2016 May-Jun.
[Is] ISSN:1945-239X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, two analytical approaches were exploited for the resolution of binary mixtures of ciprofloxacin HCl (CIP) or norfloxacin (NOR) and phenazopyridine HCl (PHZ). In the first approach, the amplitudes of the first derivative of the ratio spectra were measured at 267 or 287 nm for CIP and at 268 or 291 nm for NOR. PHZ could be directly determined in the presence of CIP or NOR at 405 nm. The calibration graphs were rectilinear over the ranges of 1.0-16.0 µg/mL for CIP or NOR and 1.0-10.0 µg/mL for PHZ. In the second approach, an accurate, reliable and environmentally nontoxic micellar liquid chromatographic (MLC) method was developed. A good chromatographic separation was achieved using a 150 mm × 4.6 mm i.d., 5 µm particle size Spherisorb ODS-2 column. Eco-friendly mobile phase containing 0.12 M sodium dodecyl sulphate, 0.3% triethylamine and 6%n-butanol in 0.02 M orthophosphoric acid of pH 3.0 was pumped at a flow rate of 1 mL/min. Time programmed UV-detection was applied to allow sensitive determination of the studied drugs. The analytes were eluted without interferences in <10 min. Methocarbamol was used as an internal standard. The MLC method was found to be rectilinear over the concentration range of 0.5-20.0 µg/mL for CIP, NOR or PHZ. These optimized and validated methods were successfully applied for the simultaneous analysis of the studied drugs in their synthetic mixtures and co-formulated tablets. Moreover, the second method was further extended to the determination of these drugs in human urine with direct injection and without any pretreatment.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Fluoroquinolonas/isolamento & purificação
Micelas
Fenazopiridina/isolamento & purificação
Espectrofotometria Ultravioleta/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones); 0 (Micelles); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160213
[St] Status:MEDLINE
[do] DOI:10.1093/chromsci/bmw010


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[PMID]:26838908
[Au] Autor:Attia KA; El-Abasawi NM; Abdel-Azim AH
[Ad] Endereço:Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751 Nasr City, Cairo, Egypt.
[Ti] Título:Experimental design of membrane sensor for selective determination of phenazopyridine hydrochloride based on computational calculations.
[So] Source:Mater Sci Eng C Mater Biol Appl;61:773-81, 2016 Apr 01.
[Is] ISSN:1873-0191
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Computational study has been done electronically and geometrically to select the most suitable ionophore to design a novel sensitive and selective electrochemical sensor for phenazopyridine hydrochloride (PAP). This study has revealed that sodium tetraphenylbarate (NaTPB) fits better with PAP than potassium tetrakis (KTClPB). The sensor design is based on the ion pair of PAP with NaTPB using dioctyl phthalate as a plasticizer. Under optimum conditions, the proposed sensor shows the slope of 59.5 mV per concentration decade in the concentration range of 1.0 × 10(-2)-1.0 × 10(-5) M with detection limit 8.5 × 10(-6) M. The sensor exhibits a very good selectivity for PAP with respect to a large number of interfering species as inorganic cations and sugars. The sensor enables track of determining PAP in the presence of its oxidative degradation product 2, 3, 6-Triaminopyridine, which is also its toxic metabolite. The proposed sensor has been successfully applied for the selective determination of PAP in pharmaceutical formulation. Also, the obtained results have been statistically compared to a reported electrochemical method indicating no significant difference between the investigated method and the reported one with respect to accuracy and precision.
[Mh] Termos MeSH primário: Técnicas Eletroquímicas
Fenazopiridina/análise
[Mh] Termos MeSH secundário: Carboidratos/química
Cátions/química
Eletrodos
Concentração de Íons de Hidrogênio
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Troca Iônica
Plastificantes/química
Projetos de Pesquisa
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Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Cations); 0 (Inorganic Chemicals); 0 (Plasticizers); 0 (Tablets); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160204
[St] Status:MEDLINE


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[PMID]:26595191
[Au] Autor:Axthelm J; Görls H; Schubert US; Schiller A
[Ad] Endereço:Institute for Inorganic and Analytical Chemistry (IAAC), Friedrich Schiller University Jena , Humboldtstrasse 8, D-07743 Jena, Germany.
[Ti] Título:Fluorinated Boronic Acid-Appended Bipyridinium Salts for Diol Recognition and Discrimination via (19)F NMR Barcodes.
[So] Source:J Am Chem Soc;137(49):15402-5, 2015 Dec 16.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Fluorinated boronic acid-appended benzyl bipyridinium salts, derived from 4,4'-, 3,4'-, and 3,3'-bipyridines, were synthesized and used to detect and differentiate diol-containing analytes at physiological conditions via (19)F NMR spectroscopy. An array of three water-soluble boronic acid receptors in combination with (19)F NMR spectroscopy discriminates nine diol-containing bioanalytes--catechol, dopamine, fructose, glucose, glucose-1-phosphate, glucose-6-phosphate, galactose, lactose, and sucrose--at low mM concentrations. Characteristic (19)F NMR fingerprints are interpreted as two-dimensional barcodes without the need of multivariate analysis techniques.
[Mh] Termos MeSH primário: Processamento Automatizado de Dados
Ácidos Borônicos/química
Técnicas de Química Analítica/métodos
Flúor/química
Espectroscopia de Ressonância Magnética
Fenazopiridina/química
[Mh] Termos MeSH secundário: Halogenação
Hidróxidos
Modelos Moleculares
Receptores de Superfície Celular/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Boronic Acids); 0 (Hydroxides); 0 (Receptors, Cell Surface); 284SYP0193 (Fluorine); 9159UV381P (hydroxide ion); K2J09EMJ52 (Phenazopyridine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151216
[Lr] Data última revisão:
151216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE
[do] DOI:10.1021/jacs.5b10934



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