Base de dados : MEDLINE
Pesquisa : D03.383.725.180 [Categoria DeCS]
Referências encontradas : 65 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 7 ir para página                  

  1 / 65 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25207431
[Au] Autor:Ali AM; Seddiek ShA; Khater HF
[Ad] Endereço:a Chemistry Department, Pharmacology Unit , Animal Health Research Institute , Benha Branch, Benha , Egypt.
[Ti] Título:Effect of butyrate, clopidol and their combination on the performance of broilers infected with Eimeria maxima.
[So] Source:Br Poult Sci;55(4):474-82, 2014.
[Is] ISSN:1466-1799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:1. The effect of butyric acid glycerides (BAGs) with and without clopidol (CLP) on Eimeria maxima on growth and associated biochemical variables was investigated in broiler chickens. 2. One-day-old chicks were divided into 6 equal groups (Gps) of 30 chicks each; each group was subdivided into 6 equal subgroups. Gp 1 was not infected and not treated. Chicks in Gp 2 were not infected and fed on a ration mixed with 4 g BAGs/kg for 6 successive weeks. Chicks of the other groups were directly inoculated intra-crop with 1 × 10(4) sporulated oocysts of E. maxima at 14 d of age. Gp 3 was infected and not treated. Chicks in the remaining three groups were given diets mixed with the tested drugs for 6 successive weeks. Gp 4 was fed on a diet mixed with CLP (125 g/kg). Gp 5 was given a diet mixed with BAGs (4 g/kg diet). Gp 6 was fed on a diet mixed with both BAGs (4 g/kg diet) and CLP (125 g/kg). 3. Birds in Gps 5 and 6 showed a reduction in the mean oocyst count, lesion scores and developmental stages in the lamina propria and improved growth and biochemical variables. BAG supplementation enhanced growth and production of healthy broilers. 4. It was concluded that BAGs were a useful supplement in broiler diets as an alternative to growth promoters and antimicrobial drugs.
[Mh] Termos MeSH primário: Butiratos/uso terapêutico
Galinhas
Clopidol/uso terapêutico
Coccidiose/veterinária
Coccidiostáticos/uso terapêutico
Eimeria/fisiologia
Doenças das Aves Domésticas/tratamento farmacológico
[Mh] Termos MeSH secundário: Ração Animal/análise
Fenômenos Fisiológicos da Nutrição Animal
Animais
Butiratos/administração & dosagem
Galinhas/fisiologia
Clopidol/administração & dosagem
Coccidiose/tratamento farmacológico
Coccidiose/parasitologia
Coccidiostáticos/administração & dosagem
Dieta/veterinária
Suplementos Nutricionais/análise
Feminino
Glicerídeos/administração & dosagem
Glicerídeos/uso terapêutico
Masculino
Doenças das Aves Domésticas/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Butyrates); 0 (Coccidiostats); 0 (Glycerides); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:141118
[Lr] Data última revisão:
141118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140911
[St] Status:MEDLINE
[do] DOI:10.1080/00071668.2014.920488


  2 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24395395
[Au] Autor:Jiang JQ; Zhang HT; Zhang HH; Wang ZL; Yang XF; Fan GY
[Ad] Endereço:Henan Institute of Science and Technology, Xinxiang, 453003, China.
[Ti] Título:Development of an enzyme-linked immunosorbent assay for detection of clopidol residues in chicken tissues.
[So] Source:J Sci Food Agric;94(11):2295-300, 2014 Aug.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Clopidol is mainly used for the prevention and treatment of coccidiosis, which poses a serious potential hazard to public health, in veterinary medicine. The aim of this study was to prepare monoclonal antibodies (mAbs) against clopidol (CLOP) and develop an immunoassay for detecting CLOP residues in chicken tissues. After derivation, CLOP hapten was conjugated to carrier proteins to synthesize the artificial antigen, and immunized Balb/C mice were employed to screen mAbs. RESULTS: A sensitive hybridoma named C1G3 was screened out and two indirect competitive enzyme-linked immunosorbent assay (icELISA) standard curves were established. For the traditional two-step assay the linear range was from 0.06 to 98 ng mL(-1) , with half-maximal inhibitory concentration (IC50 ) and limit of detection (LOD) values of 2.76 ng mL(-1) and 0.03 ng mL(-1) respectively, while the rapid one-step icELISA had a working range from 0.08 to 102 ng mL(-1) , with IC50 and LOD values of 3.52 ng mL(-1) and 0.03 ng mL(-1) respectively. It was also indicated that a 10-fold dilution in chicken muscles gave an inhibition curve almost the same as that obtained in phosphate-buffered saline. When applied to spiking tests in chicken samples, the correlation coefficient (R(2) ) between concentrations added and measured was 0.9534. CONCLUSION: The results of this study suggest that the immunoassay described is a promising alternative for screening CLOP residues in biological matrices and is suitable for routine diagnostics.
[Mh] Termos MeSH primário: Anticorpos Monoclonais
Clopidol/análise
Ensaio de Imunoadsorção Enzimática/normas
Contaminação de Alimentos/análise
Haptenos
Hibridomas
Carne/análise
[Mh] Termos MeSH secundário: Animais
Galinhas
Coccidiostáticos/análise
Dieta
Resíduos de Drogas/análise
Feminino
Haptenos/imunologia
Camundongos Endogâmicos BALB C
Músculos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies, Monoclonal); 0 (Coccidiostats); 0 (Haptens); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140701
[Lr] Data última revisão:
140701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140108
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.6557


  3 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:24669706
[Au] Autor:Song W; Hu Y; Han F; Lü Y; Zheng P; Zhou F; Chen X; Qiu J; Zhou X
[Ti] Título:[Simultaneous determination of clopidol, sulfonamide and quinolone residues in chickens by ultra performance liquid chromatography-tandem mass spectrometry].
[So] Source:Se Pu;31(12):1161-6, 2013 Dec.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:An analytical method for the simultaneous determination of clopidol, sulfadiazine, sulfamethazine, sulfametoxydiazine, sulfamethoxypyridazine, norfloxacin, ofloxacin, ciprofloxacin, enrofloxacin in chickens by ultra performance liquid chromatography coupled with tandem quadrupole mass spectrometry (UPLC-MS/MS) in positive ion mode with multiple reaction monitoring (MRM) has been developed and validated. The samples were homogenized and extracted with acetonitrile. After defatted with high speed frozen centrifugation, the supernatant solution was evaporated and the residue was dissolved with the mobile phase and defatted with n-hexane. It was then analyzed with UPLC-MS/MS. The limit of detection of this method was 0.1 microg/kg, and the limit of quantification was 0.5 microg/kg. The average recoveries (spiked at the levels of 0.5, 1.0, 2.0 microg/kg) ranged from 81.5% to 97.6%, with the relative standard deviations between 2.1% and 8.9%. The results demonstrated that the method is simple, accurate and suitable for the identification and quantification of these drug residues in chickens.
[Mh] Termos MeSH primário: Clopidol/análise
Resíduos de Drogas/análise
Contaminação de Alimentos/análise
Carne/análise
Quinolonas/análise
Sulfonamidas/análise
[Mh] Termos MeSH secundário: Animais
Galinhas
Cromatografia Líquida de Alta Pressão
Ciprofloxacino
Fluoroquinolonas
Hexanos
Norfloxacino
Ofloxacino
Sulfanilamidas
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fluoroquinolones); 0 (Hexanes); 0 (Quinolones); 0 (Sulfanilamides); 0 (Sulfonamides); 21240MF57M (sulfanilamide); 2DDG612ED8 (n-hexane); 3DX3XEK1BN (enrofloxacin); 5E8K9I0O4U (Ciprofloxacin); 8J763HFF5N (Clopidol); A4P49JAZ9H (Ofloxacin); N0F8P22L1P (Norfloxacin)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140328
[St] Status:MEDLINE


  4 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:23253274
[Au] Autor:Marcucci R; Cenci C; Cioni G; Lombardi A; Giusti B; Gensini GF
[Ad] Endereço:Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy. rossella.marcucci@unifi.it
[Ti] Título:Antiplatelets in acute coronary syndrome: personal perspectives.
[So] Source:Expert Rev Cardiovasc Ther;10(12):1487-96, 2012 Dec.
[Is] ISSN:1744-8344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:High platelet reactivity (HPR) during dual-antiplatelet therapy is a marker of vascular risk, in particular stent thrombosis, in patients with acute coronary syndromes. Genetic determinants (CYP2C19*2 polymorphism), advanced age, female gender, diabetes and reduced ventricular function are related to a higher risk to develop HPR. In addition, inflammation and increased platelet turnover, as revealed by the elevated percentage of reticulate platelets in patients' blood, that characterize the acute phase of acute coronary syndrome are associated with HPR. To overcome the limitation of clopidogrel, new antiplatelet agents (prasugrel and ticagrelor) were developed and the demonstration of their superiority over clopidogrel was obtained in the two randomized trials, TRITON TIMI 38 and PLATO. Due to the current possibility not a choice between multiple antiplatelet strategies, the future prospect is to include, in addition to clinical data and classical risk factors, the definition of platelet function during treatment in order to set a tailored therapy.
[Mh] Termos MeSH primário: Síndrome Coronariana Aguda/tratamento farmacológico
Inibidores da Agregação de Plaquetas/uso terapêutico
[Mh] Termos MeSH secundário: Síndrome Coronariana Aguda/sangue
Adenosina/análogos & derivados
Adenosina/farmacocinética
Adenosina/uso terapêutico
Plaquetas/fisiologia
Clopidol/farmacocinética
Clopidol/uso terapêutico
Seres Humanos
Piperazinas/farmacocinética
Piperazinas/uso terapêutico
Inibidores da Agregação de Plaquetas/farmacocinética
Cloridrato de Prasugrel
Tiofenos/farmacocinética
Tiofenos/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Piperazines); 0 (Platelet Aggregation Inhibitors); 0 (Thiophenes); 8J763HFF5N (Clopidol); G89JQ59I13 (Prasugrel Hydrochloride); GLH0314RVC (Ticagrelor); K72T3FS567 (Adenosine)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121221
[St] Status:MEDLINE
[do] DOI:10.1586/erc.12.153


  5 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:20944184
[Au] Autor:Brener SJ
[Ad] Endereço:New York Methodist Hospital, Brooklyn, NY, USA. sjb9005@nyp.org
[Ti] Título:Is implantation of drug-eluting stents a Faustian choice?
[So] Source:J Invasive Cardiol;22(10):465-6, 2010 Oct.
[Is] ISSN:1557-2501
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Angioplastia Coronária com Balão
Stents Farmacológicos
[Mh] Termos MeSH secundário: Clopidol/uso terapêutico
Reestenose Coronária/prevenção & controle
Trombose Coronária/etiologia
Stents Farmacológicos/efeitos adversos
Seres Humanos
Inibidores da Agregação de Plaquetas/administração & dosagem
[Pt] Tipo de publicação:COMMENT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Platelet Aggregation Inhibitors); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101015
[St] Status:MEDLINE


  6 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:20944183
[Au] Autor:Blich M; Zeidan-Shwiri T; Petcherski S; Osherov A; Hammerman H
[Ad] Endereço:Rambam Health Care Campus, Department of Cardiology, Haalia, Haifa, 91096 Israel. m_blich@rambam.health.gov.il
[Ti] Título:Incidence, predictors and outcome of drug-eluting stent thrombosis in real-world practice.
[So] Source:J Invasive Cardiol;22(10):461-4, 2010 Oct.
[Is] ISSN:1557-2501
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Traditionally, stent thrombosis (STH) has been regarded as a complication of percutaneous coronary interventions during the first 30 post-procedural days. However, delayed endothelialization associated with the implantation of drug-eluting stents (DES) may extend the risk of thrombosis beyond 30 days. Data are limited regarding the risks and the impact of this phenomenon outside clinical trials. OBJECTIVES: To evaluate the incidence, predictors and clinical outcomes of STH and premature discontinuation of thienopyridines after implantation of DES in real-world practice. METHODS: We prospectively collected data from consecutive unselected patients who underwent at least 1 DES implantation at our center from February 2006 until January 2007. The patients were followed by a phone interview or by collecting data from admission files over the course of 2 years after the implantation. Confirmed and suspected STH was defined as accepted in the medical literature. RESULTS: Three hundred fourteen patients were successfully treated with DES (436 lesions). At 20 ± 6.7 months' follow up (median 22 months), 14 patients (4.4%) had STH (incidence density 2.7 cases/100 patients-years). Five patients had early thrombosis (0-30 days), 5 patients had late STH (31-360 days from the procedure) and 4 patients had very late STH (> 360 days). Five of the 14 patients with STH died (case fatality rate, 36%). In multivariant logistic regression analysis, history of a non-cardiac thrombotic event was a risk factor for STH (p = 0.006, odds ratio [OR] 7.7, confidence interval [CI] 1.8-32.9). Clopidogrel therapy lasting less than 3 months was an independent predictor of late and very late STH (p = 0.001, OR 10.8, CI 2.7-42.9). Independent predictors of early discontinuation of thienopyridines (≤ 3 months) were Arab ethnic origin (p = 0.005, OR 19.2, CI 2.4-142), absence of cardiology follow up (p = 0.05, OR 4.7, CI 1-23.1) and absence of explanation about the clopidogrel importance at the time of hospital discharge (p = 0.001, OR 10.8, CI 2.7-42.9). CONCLUSIONS: The incidence of STH at 22- month follow up in real-world patients was substantially higher than the rate reported in previous clinical trials. Subsidizing the cost of thienopyridines, providing a clear explanation to the patient and encouraging cardiology follow up may prevent premature discontinuation of thienopyridines after implantation of DES and reduce the incidence of STH after DES implantation.
[Mh] Termos MeSH primário: Trombose Coronária/etiologia
Stents Farmacológicos/efeitos adversos
[Mh] Termos MeSH secundário: Angioplastia Coronária com Balão
Clopidol/efeitos adversos
Clopidol/uso terapêutico
Angiografia Coronária
Trombose Coronária/diagnóstico por imagem
Feminino
Seres Humanos
Masculino
Meia-Idade
Inibidores da Agregação de Plaquetas/efeitos adversos
Inibidores da Agregação de Plaquetas/uso terapêutico
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Platelet Aggregation Inhibitors); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:101015
[St] Status:MEDLINE


  7 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19822963
[Au] Autor:Fang B; Su Y; Ding H; Zhang J; He L
[Ad] Endereço:Department of Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, P. R. China.
[Ti] Título:Determination of residual clopidol in chicken muscle by capillary gas chromatography-negative chemical ionization-mass spectrometry.
[So] Source:Anal Sci;25(10):1203-6, 2009 Oct.
[Is] ISSN:1348-2246
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:A selective, sensitive gas chromatography-mass spectrometry (GC-MS) method with negative chemical ionization (NCI) was developed for the detection and quantification of clopidol in chicken muscle. Chicken muscle samples were extracted with acetonitrile and concentrated to dryness; the residue was redissolved in ethyl acetate and applied to an Alumina B cartridge for cleanup. The residue was derivatized with Sylon BFT and analyzed by GC-NCI-MS. The selected-ion monitoring mode was performed at m/z values of 156, 158, 191, and 193. The differences in the ratios for the standards and spikes in chicken muscle were within the acceptability criteria. All recoveries of the drug from chicken muscle spiked at 0.5, 5.0 and 50.0 microg/kg were 74.5-95.6% intra-day, and 71.6-94.8% inter-day, respectively, with relative standard deviations being lower than 15%. The limits of detection and quantitation were 0.1 and 0.5 microg/kg, respectively. The NCI mode had better selectivity and sensitivity than the electron impact (EI) mode for clopidol.
[Mh] Termos MeSH primário: Galinhas
Clopidol/análise
Coccidiostáticos/análise
Resíduos de Drogas/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Músculos/química
[Mh] Termos MeSH secundário: Animais
Calibragem
Clopidol/isolamento & purificação
Coccidiostáticos/isolamento & purificação
Resíduos de Drogas/isolamento & purificação
Extração em Fase Sólida
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Coccidiostats); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091014
[St] Status:MEDLINE


  8 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19626838
[Au] Autor:Yang W; Xu J; Yang G; Ding T; Qi J; Liu H; Shen C; Wu B; Yu S
[Ad] Endereço:Laboratory of Food, Jiangsu Entry-Exit Inspection and Quarantine Bureau, Nanjing 210001, China. xiaoquan025@163.com
[Ti] Título:[Determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry].
[So] Source:Se Pu;27(2):144-8, 2009 Mar.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A method is presented for the determination of clopidol residue in poultry products by liquid chromatography-electrospray ion trap tandem mass spectrometry (LC-ESI-MS/MS). Clopidol residue was extracted with methanol and cleaned-up by n-hexane from different poultry products. The extract was cleaned-up by an LC-18 column and an ion exchange solid phase extraction (SPE) column. Quantification was achieved by matrix calibration. The recoveries of clopidol in poultry products were in the range from 55.38% to 132.44% at the four spiked levels, 2, 5, 10, and 20 microg/kg. The intra-day relative standard deviation (RSD) and inter-day RSD were less than 9.54% and 15.27%, respectively. The linearity of the method was good from 1 microg/kg to 40 microg/kg. The limit of detection (LOD) was 0.5 microg/kg, and the limit of quantification (LOQ) was 2.0 microg/kg. The method is selective without interference and suitable for the determination and confirmation of clopidol residue in poultry products.
[Mh] Termos MeSH primário: Clopidol/análise
Resíduos de Drogas/análise
Produtos Avícolas/análise
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida/métodos
Contaminação de Alimentos/análise
Extração em Fase Sólida/métodos
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
8J763HFF5N (Clopidol)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090725
[St] Status:MEDLINE


  9 / 65 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:19449548
[Au] Autor:Liu X; Su Y; Fang B; Ding H; He L; Zeng Z; Chen Z
[Ad] Endereço:Department of Pharmacology and Toxicology, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
[Ti] Título:[Determination of clopidol residues in chicken muscle by gas chromatography-mass spectrometry].
[So] Source:Se Pu;27(1):86-90, 2009 Jan.
[Is] ISSN:1000-8713
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:A confirmative method to determine clopidol residues in chicken muscle by gas chromatography-mass spectrometry (GC-MS) was developed. The analyte was extracted with ace tonitrile, and then purified with an Alumina-B cartridge column. The drug was derived at 80 degrees 3 for 60 min with Sylon BFT, and more toluene was added and then applied to GC-MS. The mass spectral characteristics of trimethylsilyl derivative of clopidol were interpreted, and selected ion monitoring (SIM) mode was performed at m/z 212, 214, 248 and 263. The clopidol was qualitatively identified by the ratio of relative abundance of the selected ions and determined quantitatively by SIM mode at m/z 248. In the meantime, the matrix effect was evaluated. The range of linearity was 5.0 - 500 microg/L with the correlation coefficients better than 0.998, and the detection limit was 0.5 microg/kg (S/N = 3) for clopidol. The average recoveries from chicken muscle fortified at 5, 10 and 20 microg/kg were 77.0%, 84.5% and 89.4%, respectively, and the relative standard deviations (RSD) were less than 6.9%. The established method is simple, sensitive and reproducible for the identification and quantification of clopidol residues in chicken muscle tissue.
[Mh] Termos MeSH primário: Clopidol/análise
Coccidiostáticos/análise
Resíduos de Drogas/análise
Cromatografia Gasosa-Espectrometria de Massas
Carne/análise
[Mh] Termos MeSH secundário: Animais
Galinhas
Limite de Detecção
Músculos/química
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coccidiostats); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161018
[Lr] Data última revisão:
161018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090520
[St] Status:MEDLINE


  10 / 65 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
[PMID]:18082162
[Au] Autor:Winter RW; Kelly JX; Smilkstein MJ; Dodean R; Hinrichs D; Riscoe MK
[Ad] Endereço:Biomedical Laboratory R&D Service, Mail Code: RD-33, Experimental Chemotherapy Laboratory, VA Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, OR 97239, USA.
[Ti] Título:Antimalarial quinolones: synthesis, potency, and mechanistic studies.
[So] Source:Exp Parasitol;118(4):487-97, 2008 Apr.
[Is] ISSN:0014-4894
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present article we examine the antiplasmodial activities of novel quinolone derivatives bearing extended alkyl or alkoxy side chains terminated by a trifluoromethyl group. In the series under investigation, the IC50 values ranged from 1.2 to approximately 30 nM against chloroquine-sensitive and multidrug-resistant Plasmodium falciparum strains. Modest to significant cross-resistance was noted in evaluation of these haloalkyl- and haloalkoxyquinolones for activity against the atovaquone-resistant clinical isolate Tm90-C2B, indicating that a primary target for some of these compounds is the parasite cytochrome bc1 complex. Additional evidence to support this biochemical mechanism includes the use of oxygen biosensor plate technology to show that the quinolone derivatives block oxygen consumption by parasitized red blood cells in a fashion similar to atovaquone in side-by-side experiments. Atovaquone is extremely potent and is the only drug in clinical use that targets the Plasmodium bc1 complex, but rapid emergence of resistance to it in both mono- and combination therapy is evident and therefore additional drugs are needed to target the cytochrome bc1 complex which are active against atovaquone-resistant parasites. Our study of a number of halogenated alkyl and alkoxy 4(1H)-quinolones highlights the potential for development of "endochin-like quinolones" (ELQ), bearing an extended trifluoroalkyl moiety at the 3-position, that exhibit selective antiplasmodial effects in the low nanomolar range and inhibitory activity against chloroquine and atovaquone-resistant parasites. Further studies of halogenated alkyl- and alkoxy-quinolones may lead to the development of safe and effective therapeutics for use in treatment or prevention of malaria and other parasitic diseases.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Eritrócitos/parasitologia
Plasmodium falciparum/efeitos dos fármacos
Quinolonas/farmacologia
[Mh] Termos MeSH secundário: Animais
Antimaláricos/síntese química
Antimaláricos/química
Células Cultivadas
Clopidol/farmacologia
Coccidiostáticos/farmacologia
Resistência a Medicamentos
Sinergismo Farmacológico
Seres Humanos
Consumo de Oxigênio/efeitos dos fármacos
Plasmodium falciparum/metabolismo
Quinolonas/síntese química
Quinolonas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Antimalarials); 0 (Coccidiostats); 0 (Quinolones); 8J763HFF5N (Clopidol)
[Em] Mês de entrada:0805
[Cu] Atualização por classe:161122
[Lr] Data última revisão:
161122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:071218
[St] Status:MEDLINE



página 1 de 7 ir para página                  
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde