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[PMID]:26123880
[Au] Autor:Mulinari S
[Ad] Endereço:Department of Sociology, Faculty of Social Sciences, Lund University, Box 117, 221 00 Lund, Sweden; Department of Clinical Sciences, Unit of Social Epidemiology, Faculty of Medicine, Lund University, Malmö, Sweden. Electronic address: shai.mulinari@soc.lu.se.
[Ti] Título:Divergence and convergence of commercial and scientific priorities in drug development: The case of Zelmid, the first SSRI antidepressant.
[So] Source:Soc Sci Med;138:217-24, 2015 Aug.
[Is] ISSN:1873-5347
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Based on a realist conceptualization of interests, this paper explores how commercial and scientific priorities appear to have converged and diverged during the development of the antidepressant Zelmid. The drug represents the first of the selective serotonin reuptake inhibitors (SSRIs) to reach the market. Zelmid was synthesized in 1971 and launched by the Swedish firm Astra in 1982, but subsequently withdrawn the next year because of adverse neurological effects. This paper draws on in-depth interviews with scientists representing both industry and academia who had high-level involvement in various phases of the project (experimental, pre-clinical and clinical), as well as on textual sources such as scientific articles and memoirs. Zelmid was a product of mechanism-based or "rational" drug discovery from the early 1960s and the associated intermingling of science and commerce. It is argued that both scientists and the pharmaceutical company shared an interest in embracing mechanism-based drug discovery because it simultaneously promised medico-scientific advances and profits. However, the intermingling of science and commerce also strained the relationship between scientific and commercial priorities further along the trajectory of the drug; for example, concerning issues such as dosage strategy and drug use in primary care, where corporate management allegedly took decisions contrary to the recommendations of both academic and company scientists. On such occasions the asymmetry in power became apparent in scientists' narratives: commercial considerations trumped those of science since, ultimately, decisions rest with management, not with scientists. In addition, temporality appears to be associated with the divergence of commercial and scientific priorities. While rare during experimental and pre-clinical phases, divergence was concentrated downstream to the clinical testing and post-marketing phases. It is hypothesized that a similar pattern of convergence and divergence of commercial and scientific priorities may exist in the trajectory of other drugs.
[Mh] Termos MeSH primário: Descoberta de Drogas/história
Indústria Farmacêutica/história
Inibidores da Captação de Serotonina/história
Zimeldina/história
[Mh] Termos MeSH secundário: História do Século XX
Seres Humanos
Inibidores da Captação de Serotonina/efeitos adversos
Suécia
Zimeldina/efeitos adversos
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Serotonin Uptake Inhibitors); 3J928617DW (Zimeldine)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150710
[Lr] Data última revisão:
150710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150701
[St] Status:MEDLINE


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[PMID]:25151304
[Au] Autor:Liu YP; Huang TS; Tung CS; Lin CC
[Ad] Endereço:Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan, ROC; Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan, ROC. Electronic address: yiaping@ms75.hinet.net.
[Ti] Título:Effects of atomoxetine on attention and impulsivity in the five-choice serial reaction time task in rats with lesions of dorsal noradrenergic ascending bundle.
[So] Source:Prog Neuropsychopharmacol Biol Psychiatry;56:81-90, 2015 Jan 02.
[Is] ISSN:1878-4216
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Atomoxetine, a noradrenaline reuptake inhibitor (NRI), which is a non-stimulating medicine that is used for the treatment of patients with attention deficit hyperactivity disorder (ADHD), has been found to be effective in reducing behavioral impulsivity in rodents, but its efficacy in a dorsal noradrenergic ascending bundle (DNAB)-lesioned condition has not been examined. The present study aimed to investigate the effects of DNAB lesions on attention and impulsive control in the five-choice serial reaction time task (5-CSRTT) in rats treated with atomoxetine. The drug-induced changes in noradrenaline efflux in the medial prefrontal cortex were also measured. 5-CSRTT-trained rats were included in one of the following groups: N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)/Atomoxetine, Sham/Atomoxetine, DSP-4/Saline, or Sham/Saline. Acute atomoxetine (0.3 mg/kg) was administered 14 days after the DSP-4 regime. The behavioral testing included manipulations of the inter-trial interval (ITI), stimulation duration and food satiety. In vivo microdialysis of the noradrenaline efflux in the medial prefrontal cortex and the expression of the noradrenaline transporter (NAT) in the DNAB areas were examined. Atomoxetine reduced impulsivity and perseveration in the long-ITI condition with no effects on any other variables. This phenomenon was not influenced by DSP-4 pre-treatment. The DNAB-lesioned rats had lower noradrenaline efflux in the medial prefrontal cortex. DSP-4 caused no change in NAT expression in the DNAB areas. These findings suggested that noradrenaline reuptake may not be exclusively responsible for the atomoxetine effects in adjusting impulsivity. The role of DNAB should also be considered, particularly in conditions requiring greater behavioral inhibition.
[Mh] Termos MeSH primário: Inibidores da Captação Adrenérgica/uso terapêutico
Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico
Lesões Encefálicas/fisiopatologia
Comportamento Impulsivo/efeitos dos fármacos
Norepinefrina/análogos & derivados
Propilaminas/uso terapêutico
Tempo de Reação/efeitos dos fármacos
[Mh] Termos MeSH secundário: Adrenérgicos/toxicidade
Inibidores da Captação Adrenérgica/farmacologia
Vias Aferentes/lesões
Vias Aferentes/patologia
Animais
Cloridrato de Atomoxetina
Transtorno do Deficit de Atenção com Hiperatividade/etiologia
Benzilaminas/toxicidade
Encéfalo/efeitos dos fármacos
Encéfalo/metabolismo
Lesões Encefálicas/tratamento farmacológico
Lesões Encefálicas/patologia
Comportamento de Escolha/efeitos dos fármacos
Masculino
Microdiálise
Naltrexona/análogos & derivados
Naltrexona/toxicidade
Norepinefrina/metabolismo
Proteínas da Membrana Plasmática de Transporte de Norepinefrina/metabolismo
Propilaminas/farmacologia
Ratos
Ratos Sprague-Dawley
Zimeldina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Agents); 0 (Adrenergic Uptake Inhibitors); 0 (Benzylamines); 0 (Norepinephrine Plasma Membrane Transport Proteins); 0 (Propylamines); 3J928617DW (Zimeldine); 499-61-6 (noradrenalone); 57WVB6I2W0 (Atomoxetine Hydrochloride); 5S6W795CQM (Naltrexone); 67025-94-9 (chlornaltrexamine); PQ1P7JP5C1 (DSP 4); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140825
[St] Status:MEDLINE


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[PMID]:23160069
[Au] Autor:Wade J; Lampen J; Qi L; Tang YP
[Ad] Endereço:Department of Psychology, Michigan State University, East Lansing, MI 48824, USA. wadej@msu.edu
[Ti] Título:Norepinephrine inhibition in juvenile male zebra finches modulates adult song quality.
[So] Source:Brain Res Bull;90:132-6, 2013 Jan.
[Is] ISSN:1873-2747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:During development, male zebra finches learn a song that they eventually use in courtship and defense of nest sites. Norepinephrine (NE) is important for learning and memory in vertebrates, and this neuromodulator and its receptors are present throughout the brain regions that control song learning and production. The present study used the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) to reduce brain levels of NE in juvenile males. This manipulation inhibited the development of quality songs, with some birds producing syllables that were unusually long and/or contained frequencies that were predominantly higher than normal. These results suggest that NE is important for the acquisition of typical song.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
Aprendizagem/fisiologia
Norepinefrina/metabolismo
Canto
Vocalização Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Benzilaminas/farmacologia
Encéfalo/anatomia & histologia
Encéfalo/efeitos dos fármacos
Distribuição de Qui-Quadrado
Tentilhões
Aprendizagem/efeitos dos fármacos
Masculino
Inibidores da Captação de Neurotransmissores/farmacologia
Inibidores da Captação de Serotonina/farmacologia
Espectrografia do Som
Fatores de Tempo
Zimeldina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Benzylamines); 0 (Neurotransmitter Uptake Inhibitors); 0 (Serotonin Uptake Inhibitors); 3J928617DW (Zimeldine); PQ1P7JP5C1 (DSP 4); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121120
[St] Status:MEDLINE


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[PMID]:22516587
[Au] Autor:Scopinho AA; Fortaleza EA; Corrêa FM; Resstel LB
[Ad] Endereço:Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Bandeirantes Avenue 3900, 14049-900 Ribeirão Preto, SP, Brazil. americabiomed@yahoo.com.br
[Ti] Título:Medial amygdaloid nucleus 5-HT2c receptors are involved in the hypophagic effect caused by zimelidine in rats.
[So] Source:Neuropharmacology;63(2):301-9, 2012 Aug.
[Is] ISSN:1873-7064
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The medial amygdaloid nucleus (MeA) is a sub-region of the amygdaloid complex that has been described as participating in food intake regulation. Serotonin has been known to play an important role in appetite and food intake regulation. Moreover, serotonin 5-HT(2C) and 5-HT(1A) receptors appear to be critical in food intake regulation. We investigated the role of the serotoninergic system in the MeA on feeding behavior regulation in rats. The current study examined the effects on feeding behavior regulation of the serotonin reuptake inhibitor, zimelidine, administered directly into the MeA or given systemically, and the serotoninergic receptors mediating its effect. Our results showed that microinjection of zimelidine (0.2, 2 and 20 nmol/100 nL) into the MeA evoked dose dependent hypophagic effects in fasted rats. The selective 5-HT(1A) receptor antagonist WAY-100635 (18.5 nmol/100 nL) or the 5-HT(1B) receptor antagonist SB-216641 microinjected bilaterally into the MeA did not change the hypophagic effect evoked by local MeA zimelidine treatment. However, microinjection of the selective 5-HT(2C) receptor antagonist SB-242084 (10 nmol/100 nL) was able to block the hypophagic effect of zimelidine. Moreover, microinjection of the 5-HT(2C) receptor antagonist SB-242084 into the MeA also blocked the hypophagic effect caused by zimelidine administered systemically. These results suggest that MeA 5-HT(2C) receptors modulate the hypophagic effect caused by local MeA administration as well as by systemic zimelidine administration. Furthermore, 5-HT(2C) into the MeA could be a potential target for systemic administration of zimelidine.
[Mh] Termos MeSH primário: Tonsila do Cerebelo/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Comportamento Alimentar/efeitos dos fármacos
Receptor 5-HT2C de Serotonina/metabolismo
Inibidores da Captação de Serotonina/farmacologia
Zimeldina/farmacologia
[Mh] Termos MeSH secundário: Tonsila do Cerebelo/metabolismo
Animais
Relação Dose-Resposta a Droga
Ingestão de Alimentos/fisiologia
Comportamento Alimentar/fisiologia
Masculino
Ratos
Ratos Wistar
Antagonistas da Serotonina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Receptor, Serotonin, 5-HT2C); 0 (Serotonin Antagonists); 0 (Serotonin Uptake Inhibitors); 3J928617DW (Zimeldine)
[Em] Mês de entrada:1211
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120421
[St] Status:MEDLINE
[do] DOI:10.1016/j.neuropharm.2012.03.020


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[PMID]:25022027
[Au] Autor:Obata T; Aomine M
[Ti] Título:Effect of antidepressant drug on semicarbazide-sensitive amine oxidase (SSAO) in dog brain.
[So] Source:Res Commun Mol Pathol Pharmacol;122-123:3-12, 2009-2010.
[Is] ISSN:1078-0297
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study examined whether or not other cyclic antidepressants, such as the dicyclic drug zimeldine, the tricyclic drug imipramine, and tetracyclic drug maprotiline, and the noncyclic drug nomifensine, inhibit semicarbazide-sensitive amine oxidase (SSAO) activity in dog brain. After treatment with 100 nM clorgyline and 100 nM deprenyl, all four antidepressant drugs inhibit SSAO activity in dog brain. The most potent of inhibition was observed by imipramine, followed by maprotiline, zimeldine and nomifensine. All four drugs are noncompetitive inhibitor of SSAO in dog brain. We found the tricyclic antidepressant drug imipramine to be the most selective inhibitors of SSAO activity in dog brain, as compared with other type of antidepressant drugs.
[Mh] Termos MeSH primário: Amina Oxidase (contendo Cobre)/antagonistas & inibidores
Antidepressivos/farmacologia
Encéfalo/enzimologia
[Mh] Termos MeSH secundário: Animais
Cães
Imipramina/farmacologia
Masculino
Maprotilina/farmacologia
Nomifensina/farmacologia
Zimeldina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 1LGS5JRP31 (Nomifensine); 2U1W68TROF (Maprotiline); 3J928617DW (Zimeldine); EC 1.4.3.21 (Amine Oxidase (Copper-Containing)); OGG85SX4E4 (Imipramine)
[Em] Mês de entrada:1409
[Cu] Atualização por classe:140715
[Lr] Data última revisão:
140715
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140716
[St] Status:MEDLINE


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[PMID]:19619137
[Au] Autor:Ghai K; Zelinka C; Fischer AJ
[Ad] Endereço:Department of Neuroscience, The Ohio State University, Columbus, Ohio, USA.
[Ti] Título:Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina.
[So] Source:J Neurochem;111(1):1-14, 2009 Oct.
[Is] ISSN:1471-4159
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The neurotransmitter serotonin is synthesized in the retina by one type of amacrine neuron but accumulates in bipolar neurons in many vertebrates. The mechanisms, functions and purpose underlying serotonin accumulation in bipolar cells remain unknown. Here, we demonstrate that exogenous serotonin transiently accumulates in a distinct type of bipolar neuron. KCl-mediated depolarization causes the depletion of serotonin from amacrine neurons and, subsequently, serotonin is taken-up by bipolar neurons. The accumulation of endogenous and exogenous serotonin by bipolar neurons is blocked by selective reuptake inhibitors. Exogenous serotonin is specifically taken-up by bipolar neurons even when serotonin-synthesizing amacrine neurons are destroyed; excluding the possibility that serotonin diffuses through gap junctions from amacrine into bipolar neurons. Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. However, the vesicular monoamine transporter 2 is present only in amacrine cells suggesting that serotonin is not transported into synaptic vesicles and reused as a transmitter in the bipolar neurons. We conclude that the serotonin-accumulating bipolar neurons perform glial functions in the retina by actively transporting and degrading serotonin that is synthesized in neighboring amacrine cells.
[Mh] Termos MeSH primário: Células Amácrinas/metabolismo
Retina/citologia
Células Bipolares da Retina/metabolismo
Serotonina/metabolismo
[Mh] Termos MeSH secundário: Células Amácrinas/efeitos dos fármacos
Animais
Animais Recém-Nascidos
Galinhas
Relação Dose-Resposta a Droga
Interações Medicamentosas
Inibidores Enzimáticos/farmacologia
Proteínas de Homeodomínio/metabolismo
Cloreto de Potássio/farmacologia
Células Bipolares da Retina/efeitos dos fármacos
Serotonina/farmacologia
Inibidores da Captação de Serotonina/farmacologia
Sertralina/farmacologia
Proteínas Vesiculares de Transporte de Monoamina/genética
Proteínas Vesiculares de Transporte de Monoamina/metabolismo
Zimeldina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Homeodomain Proteins); 0 (Serotonin Uptake Inhibitors); 0 (Vesicular Monoamine Transport Proteins); 333DO1RDJY (Serotonin); 3J928617DW (Zimeldine); 660YQ98I10 (Potassium Chloride); QUC7NX6WMB (Sertraline)
[Em] Mês de entrada:0910
[Cu] Atualização por classe:161122
[Lr] Data última revisão:
161122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090722
[St] Status:MEDLINE
[do] DOI:10.1111/j.1471-4159.2009.06270.x


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[PMID]:18789911
[Au] Autor:Dabrowska J; Nowak P; Brus R
[Ad] Endereço:Department of Pharmacology, Medical University of Silesia, 38 Jordana St., 41-808 Zabrze, Poland. jdabrow@emory.edu
[Ti] Título:Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.
[So] Source:Brain Res;1239:66-76, 2008 Nov 06.
[Is] ISSN:1872-6240
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the 5-HT1A receptor reactivity after neonatal noradrenergic neurons' lesion. DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine), 50 mg/kg, was administered 30 min after a selective serotonin reuptake inhibitor (SSRI)--zimelidine (10 mg/kg) on the 1st and 3rd day of life. Zimelidine was used to prevent serotonin (5-HT) depletion. 5-HT1A autoreceptor is involved in the regulation of 5-HT release as well as the pathogenesis of depression. During a microdialysis study of anaesthetized rats, the 5-HT1A receptor agonist, R-(+)-8-OH-DPAT (0.1 mg/kg), decreased 5-HT release in the medial prefrontal cortex of control rats but this effect was significantly attenuated in DSP-4-treated animals (10-12 weeks old). To further determine which type of receptor, either pre or postsynaptically located, is involved in the attenuated response to the 5-HT1A receptor agonist in lesioned rats, behavioral tests were conducted. In the forced swimming test, DSP-4 treated rats after saline injection, displayed shorter immobility time in comparison to control rats. R-(+)-8-OH-DPAT (0.5 mg/kg) evoked an antidepressant-like effect in control and DSP-4 treated rats in a learned helplessness paradigm as well as the forced swimming test. The results of this study provided further support for the exclusive desensitization of 5-HT1A autoreceptor in adult rats with neonatal lesion of the central noradrenergic system.
[Mh] Termos MeSH primário: Adrenérgicos/toxicidade
Benzilaminas/toxicidade
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Norepinefrina/metabolismo
Receptor 5-HT1A de Serotonina/metabolismo
[Mh] Termos MeSH secundário: 8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia
Animais
Animais Recém-Nascidos
Antidepressivos/farmacologia
Depressão/tratamento farmacológico
Desamparo Aprendido
Masculino
Córtex Pré-Frontal/efeitos dos fármacos
Córtex Pré-Frontal/metabolismo
Ratos
Ratos Wistar
Serotonina/metabolismo
Agonistas de Receptores 5-HT1 de Serotonina
Agonistas de Receptores de Serotonina/farmacologia
Inibidores da Captação de Serotonina/farmacologia
Fatores de Tempo
Zimeldina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Agents); 0 (Antidepressive Agents); 0 (Benzylamines); 0 (Serotonin 5-HT1 Receptor Agonists); 0 (Serotonin Receptor Agonists); 0 (Serotonin Uptake Inhibitors); 112692-38-3 (Receptor, Serotonin, 5-HT1A); 333DO1RDJY (Serotonin); 3J928617DW (Zimeldine); 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin); PQ1P7JP5C1 (DSP 4); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:1001
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080916
[St] Status:MEDLINE
[do] DOI:10.1016/j.brainres.2008.08.054


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[PMID]:16679005
[Au] Autor:Dabrowska J; Nowak P; Brus R
[Ad] Endereço:Department of Pharmacology, Medical University of Silesia, 38 Jordana St., 41-808 Zabrze, Poland. joanna.dabrowska@dilnet.wroc.pl
[Ti] Título:Desensitization of 5-HT(1A) autoreceptors induced by neonatal DSP-4 treatment.
[So] Source:Eur Neuropsychopharmacol;17(2):129-37, 2007 Jan 15.
[Is] ISSN:0924-977X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To examine the effect of noradrenergic lesion on the reactivity of central 5-HT(1A) receptors, DSP-4 (50 mg/kg) was administered neonatally 30 min after zimelidine (10 mg/kg) administration. 5-HT(1A) autoreceptors are involved in the regulation of serotonin (5-HT) synthesis. In HPLC assay R-(+)-8-OH-DPAT (0.03 mg/kg) significantly decreased 5-HT synthesis rate in striatum, hypothalamus and frontal cortex of control, whilst nonsignificantly in DSP-4-lesioned adult rats (10-12 weeks old). To determine which type of receptor, pre- or postsynaptically located, is involved in the attenuated response to 5-HT(1A) receptors' agonist, behavioral tests were conducted. R-(+)-8-OH-DPAT (0.015 mg/kg) caused hyperphagia of control rats, but did not change feeding of DSP-4 treated rats. R-(+)-8-OH-DPAT (0.1 mg/kg) induced hypothermia and "5-HT(1A) syndrome" in both control and DSP-4-lesioned animals. The nature of this phenomenon is attributable to the presynaptic adaptive mechanism and suggests the desensitization of 5-HT(1A) autoreceptors of rats with neonatal lesion of the central noradrenergic system.
[Mh] Termos MeSH primário: Autorreceptores/metabolismo
Benzilaminas/administração & dosagem
Inibidores da Captação de Neurotransmissores/administração & dosagem
Receptores 5-HT1 de Serotonina/metabolismo
[Mh] Termos MeSH secundário: 8-Hidroxi-2-(di-n-propilamino)tetralina/administração & dosagem
Animais
Animais Recém-Nascidos
Comportamento Animal/efeitos dos fármacos
Temperatura Corporal/efeitos dos fármacos
Encéfalo/anatomia & histologia
Encéfalo/efeitos dos fármacos
Química Encefálica/efeitos dos fármacos
Interações Medicamentosas
Masculino
Piperazinas/farmacologia
Piridinas/farmacologia
Ratos
Ratos Wistar
Serotonina/metabolismo
Antagonistas da Serotonina/farmacologia
Agonistas de Receptores de Serotonina
Inibidores da Captação de Serotonina/administração & dosagem
Zimeldina/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoreceptors); 0 (Benzylamines); 0 (Neurotransmitter Uptake Inhibitors); 0 (Piperazines); 0 (Pyridines); 0 (Receptors, Serotonin, 5-HT1); 0 (Serotonin Antagonists); 0 (Serotonin Receptor Agonists); 0 (Serotonin Uptake Inhibitors); 333DO1RDJY (Serotonin); 3J928617DW (Zimeldine); 71IH826FEG (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide); 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin); PQ1P7JP5C1 (DSP 4)
[Em] Mês de entrada:0703
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060509
[St] Status:MEDLINE


  9 / 466 MEDLINE  
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Fotocópia
[PMID]:16736239
[Au] Autor:Pericic D; Strac DS; Vlainic J
[Ad] Endereço:Laboratory for Molecular Neuropharmacology, Division of Molecular Medicine, Ruder Boskovic Institute, Zagreb, Croatia. pericic@irb.hr
[Ti] Título:Zimelidine decreases seizure susceptibility in stressed mice.
[So] Source:J Neural Transm (Vienna);113(12):1863-71, 2006 Dec.
[Is] ISSN:0300-9564
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:To further evaluate whether selective serotonin reuptake inhibitors (SSRIs) have pro- or anticonvulsant properties and whether these properties will be modified by stress, we studied the effect of zimelidine on the convulsions produced by picrotoxin, a GABA(A) receptor antagonist, in unstressed and swim stressed mice. Zimelidine potentiated the ability of swim stress to enhance the threshold doses of intravenously administered picrotoxin producing convulsant signs and death, without having an effect in unstressed mice. The anticonvulsant effect of zimelidine was counteracted with mianserin, the antagonist of 5-HT(2A/2C), and diminished with WAY-100635, a selective antagonist of 5-HT(1A) receptors. In stressed mice, WAY-100635 prevented the anticonvulsant effect of 8-OH-DPAT, a 5-HT(1A) receptor agonist. SB-269970 and ketanserin, the antagonists of 5-HT(7) and 5-HT(2A) receptors, respectively, failed to reduce the effect of zimelidine. The results suggest the involvement of 5-HT(2C) and 5-HT(1A) receptors in the anticonvulsant effects of zimelidine and possibly other SSRIs in stress.
[Mh] Termos MeSH primário: Anticonvulsivantes
Convulsões/etiologia
Convulsões/prevenção & controle
Inibidores da Captação de Serotonina/farmacologia
Estresse Psicológico/complicações
Zimeldina/farmacologia
[Mh] Termos MeSH secundário: 8-Hidroxi-2-(di-n-propilamino)tetralina/farmacologia
Animais
Comportamento Animal/efeitos dos fármacos
Convulsivantes/antagonistas & inibidores
Convulsivantes/farmacologia
Ketanserina/farmacologia
Masculino
Mianserina/farmacologia
Camundongos
Camundongos Endogâmicos CBA
Fenóis/farmacologia
Picrotoxina/antagonistas & inibidores
Picrotoxina/farmacologia
Piperazinas/farmacologia
Piridinas/farmacologia
Antagonistas da Serotonina/farmacologia
Agonistas de Receptores de Serotonina/farmacologia
Sulfonamidas/farmacologia
Natação/psicologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Convulsants); 0 (Phenols); 0 (Piperazines); 0 (Pyridines); 0 (SB 269970); 0 (Serotonin Antagonists); 0 (Serotonin Receptor Agonists); 0 (Serotonin Uptake Inhibitors); 0 (Sulfonamides); 124-87-8 (Picrotoxin); 250PJI13LM (Mianserin); 3J928617DW (Zimeldine); 71IH826FEG (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide); 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin); 97F9DE4CT4 (Ketanserin)
[Em] Mês de entrada:0710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060601
[St] Status:MEDLINE


  10 / 466 MEDLINE  
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Fotocópia
[PMID]:16624257
[Au] Autor:Joca SR; Zanelati T; Guimarães FS
[Ad] Endereço:Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, 14049-900, Ribeirão Preto, SP, Brazil. samia@usp.br
[Ti] Título:Post-stress facilitation of serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus prevents learned helplessness development in rats.
[So] Source:Brain Res;1087(1):67-74, 2006 May 04.
[Is] ISSN:0006-8993
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Recent pieces of evidence suggest that the dorsal hippocampus may mediate adaptation to severe and inescapable stress, possibly by the facilitation of serotonergic and/or noradrenergic neurotransmission. Chronic social stress and high corticosteroid levels would impair this coping mechanism, predisposing animals to learned helplessness. To test the hypothesis that increasing serotonin or noradrenaline levels in the dorsal hippocampus would attenuate the development of learned helplessness (LH), rats received inescapable foot shock (IS) and were tested in a shuttle box 24 h latter. Prestressed animals showed impairment of escape responses. This effect was prevented by bilateral intrahippocampal injections of zimelidine (100 nmol/0.5 microl), a serotonin reuptake blocker, immediately after IS. This effect was not observed when zimelidine was administered before or 2 h after IS. Bilateral intrahippocampal injections of desipramine (3 or 30 nmol/0.5 microl), a noradrenaline reuptake blocker, before IS or immediately after it did not prevent LH development. Desipramine (30 nmol) enhanced LH development when injected before IS. These data suggest that poststress facilitation of hippocampal serotonergic, but not noradrenergic, neurotransmission in the dorsal hippocampus facilitates adaptation to severe inescapable stress. Antidepressant effects of noradrenaline-selective drugs seem to depend on other structures than the dorsal hippocampus.
[Mh] Termos MeSH primário: Desamparo Aprendido
Hipocampo/metabolismo
Norepinefrina/fisiologia
Serotonina/fisiologia
Estresse Fisiológico/patologia
[Mh] Termos MeSH secundário: Inibidores da Captação Adrenérgica/administração & dosagem
Animais
Comportamento Animal/efeitos dos fármacos
Desipramina/administração & dosagem
Relação Dose-Resposta a Droga
Eletrochoque/efeitos adversos
Reação de Fuga/efeitos dos fármacos
Lateralidade Funcional
Hipocampo/efeitos dos fármacos
Masculino
Ratos
Ratos Wistar
Tempo de Reação/efeitos dos fármacos
Inibidores da Captação de Serotonina/administração & dosagem
Estresse Fisiológico/complicações
Estresse Fisiológico/metabolismo
Zimeldina/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adrenergic Uptake Inhibitors); 0 (Serotonin Uptake Inhibitors); 333DO1RDJY (Serotonin); 3J928617DW (Zimeldine); TG537D343B (Desipramine); X4W3ENH1CV (Norepinephrine)
[Em] Mês de entrada:0608
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060421
[St] Status:MEDLINE



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