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[PMID]:28457669
[Au] Autor:Kamens HM; Peck C; Garrity C; Gechlik A; Jenkins BC; Rajan A
[Ad] Endereço:Department of Biobehavioral Health, Penn State University, University Park, PA, USA; Center for Brain, Behavior, and Cognition, Penn State University, University Park, PA, USA. Electronic address: hmk123@psu.edu.
[Ti] Título:α6ß2 nicotinic acetylcholine receptors influence locomotor activity and ethanol consumption.
[So] Source:Alcohol;61:43-49, 2017 Jun.
[Is] ISSN:1873-6823
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nicotinic acetylcholine receptors (nAChRs) in the mesolimbic dopamine system have been implicated in ethanol behaviors. In particular, work in genetically engineered mice has demonstrated that α6-containing nAChRs are involved in ethanol consumption and sedation. A limitation of these studies is that the alteration in the receptor was present throughout development. The recently described α6ß2 antagonist, N,N-decane-1,10-diyl-bis-3-picolinium diiodide (bPiDI), now makes it possible to test for the involvement of these receptors using a pharmacological approach. The aim of this study was to examine the role of α6ß2 nAChRs in ethanol behaviors using a pharmacological approach. Adolescent C57BL/6J mice were treated with bPiDI 30 min prior to testing the mice for binge-like ethanol consumption in the drinking-in-the-dark (DID) test, ethanol-induced motor incoordination using the balance beam, and ethanol-induced sedation using the Loss of Righting Reflex (LORR) paradigm. Adolescent animals were chosen because they express a high amount of α6 mRNA relative to adult animals. Control studies were also performed to determine the effect of bPiDI on locomotor activity and ethanol metabolism. Female mice treated with 20 mg/kg bPiDI had reduced locomotor activity compared to saline-treated animals during the first 30 min following an acute injection. Pretreatment with the α6ß2 antagonist reduced adolescent ethanol consumption but also reduced saccharin consumption. No significant effects were observed on ethanol-induced ataxia, sedation, or metabolism. This study provides evidence that α6ß2 nAChRs are involved in locomotor activity as well as ethanol and saccharin consumption in adolescent animals.
[Mh] Termos MeSH primário: Consumo de Bebidas Alcoólicas/fisiopatologia
Etanol/administração & dosagem
Locomoção/efeitos dos fármacos
Receptores Nicotínicos/fisiologia
[Mh] Termos MeSH secundário: Consumo de Bebidas Alcoólicas/prevenção & controle
Animais
Bebedeira/fisiopatologia
Etanol/efeitos adversos
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Antagonistas Nicotínicos/farmacologia
Picolinas/farmacologia
Compostos de Piridínio/farmacologia
Sacarina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (N,N-decane-1,10-diyl-bis-3-picolinium); 0 (Nicotinic Antagonists); 0 (Picolines); 0 (Pyridinium Compounds); 0 (Receptors, Nicotinic); 0 (alpha6beta2 nicotinic acetylcholine receptor); 3K9958V90M (Ethanol); FST467XS7D (Saccharin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:29232581
[Au] Autor:Rahman FU; Bhatti MZ; Ali A; Duong HQ; Zhang Y; Yang B; Koppireddi S; Lin Y; Wang H; Li ZT; Zhang DW
[Ad] Endereço:Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China; Department of Materials Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
[Ti] Título:Homo- and heteroleptic Pt(II) complexes of ONN donor hydrazone and 4-picoline: A synthetic, structural and detailed mechanistic anticancer investigation.
[So] Source:Eur J Med Chem;143:1039-1052, 2018 Jan 01.
[Is] ISSN:1768-3254
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Two series of homoleptic Pt(II)(hydrazone)Cl (C1a-C5a) and heteroleptic Pt(II)(hydrazone)(4-picoline). BF (C1b-C5b) complexes were prepared and characterized by H, C, F NMR and HR ESI-MS. Structure of C2b was confirmed by single crystal X-ray analysis. These complexes were studied for their in vitro anticancer activities in human multiple cancer cells including breast (MCF-7), liver (HepG2), lung (H460), colon (HCT116) and cervical (Hela) cancers. C1a-C5a and C1b-C5b showed considerable anticancer effect. The overall anticancer effect of all these complexes was higher in liver (HepG2) and lung (H460) cancer cell lines and the effect of C2b and C3b was observed to be the highest among these 10 complexes. Therefore, we selected C2b and C3b to study their in vitro anticancer mechanism in HepG2 and H460 cancer cells. C2b and C3b changed cancer cell morphology and inhibited cell migration. The anticancer mechanistic studies demonstrated that C2b and C3b induced cell apoptosis, as evidenced by DAPI and AO/EB staining and flow cytometry analyses. Moreover, qRT-PCR and western blotting analysis showed that H460 and HepG2 cells treated with C2b and C3b significantly increased the expression of p53, p63, p21, p15, Bax and decreased Bcl-2 and c-Myc levels. The DNA binding property of these complexes was investigated by gel electrophoresis using pBR322 plasmid DNA. Taken together, the results obtained from the present study demonstrated the potentials of this new class of Pt(II) complexes in reduction of cell viability, suppression of cell migration and acceleration of apoptosis in different cancer cells.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Hidrazonas/farmacologia
Compostos Organoplatínicos/farmacologia
Picolinas/farmacologia
Platina/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/síntese química
Antineoplásicos/química
Apoptose/efeitos dos fármacos
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Seres Humanos
Hidrazonas/química
Estrutura Molecular
Compostos Organoplatínicos/síntese química
Compostos Organoplatínicos/química
Picolinas/química
Platina/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Hydrazones); 0 (Organoplatinum Compounds); 0 (Picolines); 49DFR088MY (Platinum)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180101
[Lr] Data última revisão:
180101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE


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[PMID]:28802632
[Au] Autor:Han X; Jiang M; Zhou C; Zhou Z; Xu Z; Wang L; Mayweg AV; Niu R; Jin TG; Yang S
[Ad] Endereço:Medicinal Chemistry, Roche Innovation Center Shanghai, Bldg 5, 720 Cailun Road, Shanghai 201203, China. Electronic address: cyrus.han@roche.com.
[Ti] Título:Discovery of potent and selective CDK8 inhibitors through FBDD approach.
[So] Source:Bioorg Med Chem Lett;27(18):4488-4492, 2017 09 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A fragment library screen was carried out to identify starting points for novel CDK8 inhibitors. Optimization of a fragment hit guided by co-crystal structures led to identification of a novel series of potent CDK8 inhibitors which are highly ligand efficient, kinase selective and cellular active. Compound 16 was progressed to a mouse pharmacokinetic study and showed good oral bioavailability.
[Mh] Termos MeSH primário: Quinase 8 Dependente de Ciclina/antagonistas & inibidores
Descoberta de Drogas
Picolinas/farmacologia
[Mh] Termos MeSH secundário: Animais
Quinase 8 Dependente de Ciclina/metabolismo
Relação Dose-Resposta a Droga
Seres Humanos
Ligantes
Camundongos
Modelos Moleculares
Estrutura Molecular
Picolinas/síntese química
Picolinas/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (4-methylpyridine); 0 (Ligands); 0 (Picolines); EC 2.7.11.22 (CDK8 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinase 8)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170814
[St] Status:MEDLINE


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[PMID]:28673219
[Au] Autor:Labuschagne GS; Morris RW
[Ad] Endereço:Visiting Medical Officer, Department of Anaesthesia, St George Hospital, Sydney, New South Wales.
[Ti] Título:The effect of oral intake during the immediate pre-colonoscopy time period on volume depletion in patients who receive sodium picosulfate.
[So] Source:Anaesth Intensive Care;45(4):485-489, 2017 07.
[Is] ISSN:0310-057X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Sodium picosulfate, used in combination with magnesium oxide and citric acid for bowel cleansing, can result in dehydration. We investigated whether enhanced carbohydrate fluid intake pre-colonoscopy could mitigate this effect. We enrolled 398 elective colonoscopy patients in a prospective, controlled, single-blinded study. The control group (n=194) fasted routinely (minimum seven hours) whilst the treatment group (n=197) drank 1,200 ml carbohydrate solution leading up to admission (up until two hours pre-colonoscopy). On admission a patient survey was completed, and urine specific gravity obtained. Supine blood pressure and pulse rate were measured, and repeated within three minutes of standing. The carbohydrate group had reduced symptoms and signs of dehydration, including thirst (34% versus 65%, <0.001), dry mouth (45% versus 59%, =0.008), dizziness (10% versus 20%, =0.010), lower mean urine specific gravity (1.007 versus 1.017, <0.001), lower incidence of orthostatic hypotension (2.6% versus 11%, <0.001), and lower mean erect pulse rate (78 versus 81 /minute, =0.047). The postural change in systolic blood pressure was less in the treatment group (mean -0.4 mmHg, median -1 mmHg [interquartile range, IQR -7 to 7]) than in the control group (mean -4.1 mmHg, median -1 mmHg [IQR -12 to 3], =0.028). These findings indicate that hydration with carbohydrate solution in patients taking sodium picosulfate has clinical benefit.
[Mh] Termos MeSH primário: Citratos/efeitos adversos
Colonoscopia/métodos
Desidratação/prevenção & controle
Compostos Organometálicos/efeitos adversos
Picolinas/efeitos adversos
Cuidados Pré-Operatórios
[Mh] Termos MeSH secundário: Carboidratos/administração & dosagem
Ingestão de Líquidos
Seres Humanos
Hipotensão Ortostática/prevenção & controle
Meia-Idade
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Carbohydrates); 0 (Citrates); 0 (Organometallic Compounds); 0 (Picolines); LR57574HN8 (picosulfate sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28481923
[Au] Autor:Liu T; Liang Y; Chu G
[Ad] Endereço:The Key Laboratory of Oasis Eco-agriculture, Xinjiang Production and Construction group, College of Agriculture, Shihezi University, Shihezi, P. R. China.
[Ti] Título:Nitrapyrin addition mitigates nitrous oxide emissions and raises nitrogen use efficiency in plastic-film-mulched drip-fertigated cotton field.
[So] Source:PLoS One;12(5):e0176305, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nitrification inhibitors (NIs) have been used extensively to reduce nitrogen losses and increase crop nitrogen nutrition. However, information is still scant regarding the influence of NIs on nitrogen transformation, nitrous oxide (N2O) emission and nitrogen utilization in plastic-film-mulched calcareous soil under high frequency drip-fertigated condition. Therefore, a field trial was conducted to evaluate the effect of nitrapyrin (2-chloro-6-(trichloromethyl)-pyridine) on soil mineral nitrogen (N) transformation, N2O emission and nitrogen use efficiency (NUE) in a drip-fertigated cotton-growing calcareous field. Three treatments were established: control (no N fertilizer), urea (225 kg N ha-1) and urea+nitrapyrin (225 kg N ha-1+2.25 kg nitrapyrin ha-1). Compared with urea alone, urea plus nitrapyrin decreased the average N2O emission fluxes by 6.6-21.8% in June, July and August significantly in a drip-fertigation cycle. Urea application increased the seasonal cumulative N2O emission by 2.4 kg N ha-1 compared with control, and nitrapyrin addition significantly mitigated the seasonal N2O emission by 14.3% compared with urea only. During the main growing season, the average soil ammonium nitrogen (NH4+-N) concentration was 28.0% greater and soil nitrate nitrogen (NO3--N) concentration was 13.8% less in the urea+nitrapyrin treatment than in the urea treatment. Soil NO3--N and water-filled pore space (WFPS) were more closely correlated than soil NH4+-N with soil N2O fluxes under drip-fertigated condition (P<0.001). Compared with urea alone, urea plus nitrapyrin reduced the seasonal N2O emission factor (EF) by 32.4% while increasing nitrogen use efficiency by 10.7%. The results demonstrated that nitrapyrin addition significantly inhibited soil nitrification and maintained more NH4+-N in soil, mitigated N2O losses and improved nitrogen use efficiency in plastic-film-mulched calcareous soil under high frequency drip-fertigated condition.
[Mh] Termos MeSH primário: Fertilizantes
Gossypium
Nitrogênio/análise
Óxido Nitroso/análise
Picolinas/farmacologia
Plásticos
[Mh] Termos MeSH secundário: China
Produtos Agrícolas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Picolines); 0 (Plastics); 8PCE86U01W (nitrapyrin); K50XQU1029 (Nitrous Oxide); N762921K75 (Nitrogen)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0176305


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[PMID]:28377170
[Au] Autor:Rice DR; de Lourdes Betancourt Mendiola M; Murillo-Solano C; Checkley LA; Ferdig MT; Pizarro JC; Smith BD
[Ad] Endereço:Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
[Ti] Título:Antiplasmodial activity of targeted zinc(II)-dipicolylamine complexes.
[So] Source:Bioorg Med Chem;25(10):2754-2760, 2017 May 15.
[Is] ISSN:1464-3391
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study measured the antiplasmodial activity of nine zinc-dipicolylamine (ZnDPA) complexes against three strains of Plasmodium falciparum, the causative parasite of malaria. Growth inhibition assays showed significant activity against all tested strains, with 50% inhibitory concentrations between 5 and 600nM and almost no toxic effect against host cells including healthy red blood cells. Fluorescence microscopy studies with a green-fluorescent ZnDPA probe showed selective targeting of infected red blood cells. The results suggest that ZnDPA coordination complexes are promising antiplasmodial agents with potential for targeted malaria treatment.
[Mh] Termos MeSH primário: Antimaláricos/química
Complexos de Coordenação/química
Compostos Organometálicos/química
Picolinas/química
[Mh] Termos MeSH secundário: Animais
Antimaláricos/síntese química
Antimaláricos/uso terapêutico
Antimaláricos/toxicidade
Células CHO
Proliferação Celular/efeitos dos fármacos
Complexos de Coordenação/síntese química
Complexos de Coordenação/uso terapêutico
Complexos de Coordenação/toxicidade
Cricetinae
Cricetulus
Eritrócitos/efeitos dos fármacos
Eritrócitos/parasitologia
Hemólise/efeitos dos fármacos
Seres Humanos
Malária/tratamento farmacológico
Microscopia de Fluorescência
Plasmodium falciparum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Coordination Complexes); 0 (Organometallic Compounds); 0 (Picolines); 0 (zinc(II) dipicolylamine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE


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[PMID]:28374694
[Au] Autor:Berezina IY; Badalyan AV; Sumsky LI; Gol'dfarb YS
[Ad] Endereço:Sklifosovsky Research Institute for Emergency Medicine, Public Healthcare Institution of Moscow Healthcare Department, Moscow, Russia.
[Ti] Título:[Dynamics of eeg and psychophysiological indicators of acute poisoning neurotoxicants on the stage of rehabilitation on the background of different methods of treatment].
[Ti] Título:Dinamika elektroentsefalograficheskikh i psikhofiziologicheskikh pokazatelei pri ostrykh otravleniyakh neirotoksikantami na etape reabilitatsii na fone razlichnykh metodov lecheniya..
[So] Source:Zh Nevrol Psikhiatr Im S S Korsakova;117(2):53-63, 2017.
[Is] ISSN:1997-7298
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To evaluate the dynamics of functional activity of brain structures underlying cognitive functions in patients with encephalopathy due to poisoning with neurotoxicants on the stage of rehabilitation. MATERIAL AND METHODS: Fifty-six patients were examined. The main group consisted of 40 patients treated with intravenous injections with mexidol (n=10), combination of mexidol with non-pharmacological methods - mesodiencephalic modulation (MDM) (n=10), hyperbaric oxygenation (HBO) (n=10) and the combination of MDM and HBO (n=10). The comparison group included 16 people. All patients underwent neurophysiological (EEG, auditory event-related potentials) and neuropsychological examinations. RESULTS: Marked EEG changes were noted in all patients. The domination of disturbances of functional activity on the diencephalic or mesodiencephalic levels was observed. After treatment, positive changes were found in 60% of patients. The positive dynamics was observed in 80% patients when the combination of mexidol, MDM and HBO was used. The negative dynamics was noted in 5 (12,5%) of patients of the main group, in particular when mexidol only was used. The results of the primary neuropsychological study revealed that cognitive impairment of different severity was found in 97,5% of patients of the main group and 100% of patients of the comparison group. After treatment, performance on neuropsychological tests improved by 62,5%, N200 and P300 latencies reduced, while the amplitudes increased, in the patients of the main group. CONCLUSION: The use of mexidol, MDM and HBO in the treatment of patients with encephalopathy due to poisoning with neurotoxicants on the stage of rehabilitation improved the indicators of functional brain activity and cognitive functions.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Encéfalo/fisiopatologia
Oxigenação Hiperbárica
Síndromes Neurotóxicas/fisiopatologia
Síndromes Neurotóxicas/reabilitação
Picolinas/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Antioxidantes/administração & dosagem
Cognição/fisiologia
Disfunção Cognitiva/induzido quimicamente
Disfunção Cognitiva/reabilitação
Terapia Combinada
Eletroencefalografia
Potenciais Evocados
Feminino
Seres Humanos
Injeções Intravenosas
Masculino
Testes Neuropsicológicos
Síndromes Neurotóxicas/tratamento farmacológico
Picolinas/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Picolines); 2R985002CT (emoxypine succinate)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.17116/jnevro20171172153-63


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[PMID]:27987136
[Au] Autor:Prasad VG; Abraham P
[Ad] Endereço:VGM Hospital, 2100, Trichy Road, Coimbatore, 641 005, India. drvgm@rediffmail.com.
[Ti] Título:Management of chronic constipation in patients with diabetes mellitus.
[So] Source:Indian J Gastroenterol;36(1):11-22, 2017 Jan.
[Is] ISSN:0975-0711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:AIM: The aim of this review is to provide an overview of the clinical assessment and evidence-based treatment options for managing diabetes-associated chronic constipation. METHODS: A literature search of published medical reports in English language was performed using the OVID Portal, from PUBMED and the Cochrane Database of Systematic Reviews, from inception to October 2015. A total of 145 abstracts were identified; duplicate publications were removed and 95 relevant full-text articles were retrieved for potential inclusion. RESULTS: Chronic constipation is one of the most common gastrointestinal symptoms in patients with diabetes, and occurs more frequently than in healthy individuals. Treatment goals include improving symptoms and restoring bowel function by accelerating colonic transit and facilitating defecation. Based on guidelines and data from published literature, food and dietary change with exercise and lifestyle change should be the first step in management. For patients recalcitrant to these changes, laxatives should be the next step of treatment. Treatment should begin with bulking agents such as psyllium, bran or methylcellulose followed by osmotic laxatives if response is poor. Lactulose, polyethylene glycol and lactitol are the most frequently prescribed osmotic agents. Lactulose has a prebiotic effect and a carry-over effect (continued laxative effect for at least 6 to 7 days, post cessation of treatment). Stimulants such as bisacodyl, sodium picosulphate and senna are indicated if osmotic laxatives are not effective. Newer agents such as chloride-channel activators and 5-HT4 agonist can be considered for severe or resistant cases. CONCLUSION: The primary aim of intervention in diabetic patients with chronic constipation is to better manage the diabetes along with management of constipation. The physician should explain the rationale for prescribing laxatives and educate patients about the potential drawbacks of long-term use of laxatives. They should contact their physician if short-term use of prescribed laxative fails to provide relief.
[Mh] Termos MeSH primário: Constipação Intestinal/etiologia
Constipação Intestinal/terapia
Complicações do Diabetes/complicações
[Mh] Termos MeSH secundário: Bisacodil/administração & dosagem
Agonistas dos Canais de Cloreto/administração & dosagem
Doença Crônica
Citratos/administração & dosagem
Fibras na Dieta/administração & dosagem
Medicina Baseada em Evidências
Terapia por Exercício
Estilo de Vida Saudável
Seres Humanos
Laxantes/administração & dosagem
Metilcelulose/administração & dosagem
Compostos Organometálicos/administração & dosagem
Picolinas/administração & dosagem
Psyllium/administração & dosagem
Extrato de Sena/administração & dosagem
Agonistas de Receptores 5-HT4 de Serotonina/administração & dosagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Chloride Channel Agonists); 0 (Citrates); 0 (Dietary Fiber); 0 (Laxatives); 0 (Organometallic Compounds); 0 (Picolines); 0 (Serotonin 5-HT4 Receptor Agonists); 10X0709Y6I (Bisacodyl); 8013-11-4 (Senna Extract); 8063-16-9 (Psyllium); 9004-67-5 (Methylcellulose); LR57574HN8 (picosulfate sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161218
[St] Status:MEDLINE
[do] DOI:10.1007/s12664-016-0724-2


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[PMID]:27736795
[Au] Autor:Voiosu T; Tantau A; Voiosu A; Bengus A; Mocanu C; Smarandache B; Baicus C; Visovan I; Mateescu B
[Ti] Título:Preparation regimen is more important than patient-related factors: a randomized trial comparing a standard bowel preparation before colonoscopy with an individualized approach.
[So] Source:Rom J Intern Med;55(1):36-43, 2017 Mar 01.
[Is] ISSN:1220-4749
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Optimal bowel preparation is one of the most important factors affecting the quality of colonoscopy. Several patient-related factors are known to influence the quality of bowel cleansing but randomized trials in this area are lacking. We aimed to compare an individualized bowel prep strategy based on patient characteristics to a standard preparation regimen. MATERIAL AND METHODS: We conducted an endoscopist-blinded multicenter randomized control-trial. The Boston Bowel Prep Score (BBPS) was used to assess quality of bowel preparation and a 10 point visual analogue scale to assess patient comfort during bowel prep. Patients were randomised to either the standard regimens of split-dose 4L polyethylene-glycol (group A), split-dose sodium picosulphate/magnesium citrate (group B) or to either of the two depending on their responses to a 3-item questionnaire (individualized preparation, group C). RESULTS: 185 patients were randomized during the study period and 143 patients were included in the final analysis. Patients in the individualized group had a median BBPS of 7 compared to a median of 6 in the standard group (p = 0.7). Also, there was no significant difference in patients' comfort scores, irrespective of study group or laxative regimen. However, on multivariable analysis, a split-dose 4L polyethylene-glycol was an independent predictor for achieving a BBPS>6 (OR 3.7, 95% CI 1.4-9.8), regardless of patient-related factors. CONCLUSION: The choice of laxative seems to be more important than patient-related factors in predicting bowel cleansing. Comfort during bowel prep is not influenced by the type of strategy used.
[Mh] Termos MeSH primário: Catárticos/administração & dosagem
Citratos/administração & dosagem
Ácido Cítrico/administração & dosagem
Colonoscopia
Compostos Organometálicos/administração & dosagem
Cooperação do Paciente
Satisfação do Paciente
Picolinas/administração & dosagem
Polietilenoglicóis/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Cuidados Pré-Operatórios/métodos
Romênia
Método Simples-Cego
Inquéritos e Questionários
Centros de Atenção Terciária
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 0 (Citrates); 0 (Organometallic Compounds); 0 (Picolines); 2968PHW8QP (Citric Acid); 30IQX730WE (Polyethylene Glycols); LR57574HN8 (picosulfate sodium); RHO26O1T9V (magnesium citrate)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170707
[Lr] Data última revisão:
170707
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27451294
[Au] Autor:Hookey L; Louw J; Wiepjes M; Rubinger N; Van Weyenberg S; Day AG; Paterson W
[Ad] Endereço:Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
[Ti] Título:Lack of benefit of active preparation compared with a clear fluid-only diet in small-bowel visualization for video capsule endoscopy: results of a randomized, blinded, controlled trial.
[So] Source:Gastrointest Endosc;85(1):187-193, 2017 Jan.
[Is] ISSN:1097-6779
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Controversy remains regarding the type and amount of precapsule bowel cleansing required for small-bowel video capsule endoscopy (VCE). This study aims to assess the efficacy and tolerance of 2 active preparations and a control group of clear fluids only. METHODS: Patients with clinical indications for VCE were randomized to (1) clear fluids only the evening before VCE, (2) 2 sachets of sodium picosulfate plus magnesium sulfate (P/MC) the evening before, or (3) 2 L of polyethylene glycol (PEG) the evening before. Diet instructions were the same for all 3 groups. Small-bowel cleansing was assessed in 3 ways: a 5-point ordinal scale (primary outcome), the percentage of time the small-bowel view was clear, and a validated computerized assessment of cleansing. RESULTS: In total, 198 patients were randomized and 175 patients completed the trial with a mean age of 49.2 years. There was no clear benefit of active preparation with either P/MC or PEG over clear fluids only in the overall 5-point rating scale or in the distal fourth of each examination. There was no difference in diagnostic yield between groups. Significant differences were seen concerning tolerance of the preparations, with a higher proportion rating it as easy or very easy in the clear fluids-only group (93%) and the P/MC group (67%) than in the PEG group (13%) (P < .0001). CONCLUSIONS: Small-bowel cleansing for VCE remains a controversial topic. This randomized control trial demonstrates no benefit in overall or distal small-bowel visualization with active preparation using either PEG or P/MC compared with clear fluids only. (Clinical trial registration number: NCT00677794.).
[Mh] Termos MeSH primário: Endoscopia por Cápsula/métodos
Catárticos/administração & dosagem
Dieta
Aceitação pelo Paciente de Cuidados de Saúde
[Mh] Termos MeSH secundário: Adulto
Idoso
Bebidas
Catárticos/efeitos adversos
Citratos/administração & dosagem
Feminino
Seres Humanos
Intestino Delgado
Sulfato de Magnésio/administração & dosagem
Masculino
Meia-Idade
Compostos Organometálicos/administração & dosagem
Picolinas/administração & dosagem
Polietilenoglicóis/administração & dosagem
Estudos Prospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Cathartics); 0 (Citrates); 0 (Organometallic Compounds); 0 (Picolines); 30IQX730WE (Polyethylene Glycols); 7487-88-9 (Magnesium Sulfate); LR57574HN8 (picosulfate sodium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE



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